JPS5618948A - Peptide derivative - Google Patents
Peptide derivativeInfo
- Publication number
- JPS5618948A JPS5618948A JP9408679A JP9408679A JPS5618948A JP S5618948 A JPS5618948 A JP S5618948A JP 9408679 A JP9408679 A JP 9408679A JP 9408679 A JP9408679 A JP 9408679A JP S5618948 A JPS5618948 A JP S5618948A
- Authority
- JP
- Japan
- Prior art keywords
- prolyl
- leucyl
- formula
- peptide derivative
- carbobenzoxyglycyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- ZQEBQGAAWMOMAI-ZETCQYMHSA-N (2s)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid Chemical compound CC(C)(C)OC(=O)N1CCC[C@H]1C(O)=O ZQEBQGAAWMOMAI-ZETCQYMHSA-N 0.000 abstract 1
- 102000029816 Collagenase Human genes 0.000 abstract 1
- 108060005980 Collagenase Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 229960002424 collagenase Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- GLNDAGDHSLMOKX-UHFFFAOYSA-N coumarin 120 Chemical compound C1=C(N)C=CC2=C1OC(=O)C=C2C GLNDAGDHSLMOKX-UHFFFAOYSA-N 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003248 enzyme activator Substances 0.000 abstract 1
- -1 glycyl-prolyl-leucyl Chemical group 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000019833 protease Nutrition 0.000 abstract 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:A peptide derivative shown by the formula I (R is prolyl-leucyl, glycyl-prolyl-leucyl, prolyl-alanyl, etc.; X is a group shown by the formula II or III).
EXAMPLE: ( N-carbobenzoxyglycyl-L-prolyl-L-leucyl-glycyl-L-prolyl )-4-methylcoumaryl-7-amide.
USE: A base for measuring a specific enzyme activator e.g., peptidase similar to collagenase useful for diagnosis of disease of a viscus, e.g., the liver, the kidney, etc. and its synthetic intermediate.
PROCESS: t-Butyloxycarbonyl-L-proline is reacted with 7-amino-4-methyl coumarin to give (N-t-butyloxycarbonyl-L-proline)-4-methyl-coumaryl-7-amide, which is reacted with carbobenzoxyglycyl-L-prolyl-L-leucyl-glycine to give a compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9408679A JPS5618948A (en) | 1979-07-24 | 1979-07-24 | Peptide derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9408679A JPS5618948A (en) | 1979-07-24 | 1979-07-24 | Peptide derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5618948A true JPS5618948A (en) | 1981-02-23 |
Family
ID=14100654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9408679A Pending JPS5618948A (en) | 1979-07-24 | 1979-07-24 | Peptide derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5618948A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5115098A (en) * | 1990-02-28 | 1992-05-19 | President And Fellows Of Harvard College | End-blocked peptides inhibiting binding capacity of gp120 |
| JP2014510052A (en) * | 2011-02-18 | 2014-04-24 | アイエスピー インベストメンツ インコーポレイテッド | Novel peptide that activates extracellular matrix protein synthesis and cosmetic composition containing the same |
-
1979
- 1979-07-24 JP JP9408679A patent/JPS5618948A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5115098A (en) * | 1990-02-28 | 1992-05-19 | President And Fellows Of Harvard College | End-blocked peptides inhibiting binding capacity of gp120 |
| JP2014510052A (en) * | 2011-02-18 | 2014-04-24 | アイエスピー インベストメンツ インコーポレイテッド | Novel peptide that activates extracellular matrix protein synthesis and cosmetic composition containing the same |
| US8809276B2 (en) * | 2011-02-18 | 2014-08-19 | Isp Investments Inc. | Activator peptides for synthesizing extracellular matrix proteins, and cosmetic compositions including same |
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