JPS562976A - Benzoxazine derivative and its preparation - Google Patents
Benzoxazine derivative and its preparationInfo
- Publication number
- JPS562976A JPS562976A JP7703279A JP7703279A JPS562976A JP S562976 A JPS562976 A JP S562976A JP 7703279 A JP7703279 A JP 7703279A JP 7703279 A JP7703279 A JP 7703279A JP S562976 A JPS562976 A JP S562976A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- hydrocarbon residue
- carbonyl
- methylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000005130 benzoxazines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- IQTZROFGQTWKGQ-UHFFFAOYSA-N methyl 2-(3,4-dihydro-2H-1,4-benzoxazin-2-yl)acetate Chemical compound C1=CC=C2OC(CC(=O)OC)CNC2=C1 IQTZROFGQTWKGQ-UHFFFAOYSA-N 0.000 abstract 1
- -1 methylene, carbonyl Chemical group 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 238000005987 sulfurization reaction Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I (R1 is H or hydrocarbon residue; one of R2 and R3 is electrically negative group and the other is H or hydrocarbon residue; X is methylene, carbonyl or thiocarbonyl; A may have a substitution group).
EXAMPLE: 3,4-Dihydro-2H-1,4-benzoxazine-2-acetic acid methyl ester.
USE: Medicines and their intermedates. It has analgesic, antiphlogistic, antidepressive and antispasmodic actions.
PROCESS: The objective compound of formula I is prepared by reacting a compound of formula II with a compound of formula III (X' is methylene or carbonyl; Y is halogen), and subjecting the resulting compound of formula IV to cyclization and if necessary, hydrolysis, reduction, sulfurization, introduction of hydrocarbon residue, etc.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7703279A JPS562976A (en) | 1979-06-18 | 1979-06-18 | Benzoxazine derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7703279A JPS562976A (en) | 1979-06-18 | 1979-06-18 | Benzoxazine derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS562976A true JPS562976A (en) | 1981-01-13 |
Family
ID=13622406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7703279A Pending JPS562976A (en) | 1979-06-18 | 1979-06-18 | Benzoxazine derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS562976A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02250200A (en) * | 1989-03-23 | 1990-10-05 | Anritsu Corp | Information transmission monitor device |
| JPH0570414A (en) * | 1991-03-27 | 1993-03-23 | Merck & Co Inc | HIV-1 reverse transcriptase inhibitor |
-
1979
- 1979-06-18 JP JP7703279A patent/JPS562976A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02250200A (en) * | 1989-03-23 | 1990-10-05 | Anritsu Corp | Information transmission monitor device |
| JPH0570414A (en) * | 1991-03-27 | 1993-03-23 | Merck & Co Inc | HIV-1 reverse transcriptase inhibitor |
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