JPS565474A - 4-ethoxy-2-pyrone derivative - Google Patents

4-ethoxy-2-pyrone derivative

Info

Publication number
JPS565474A
JPS565474A JP8086979A JP8086979A JPS565474A JP S565474 A JPS565474 A JP S565474A JP 8086979 A JP8086979 A JP 8086979A JP 8086979 A JP8086979 A JP 8086979A JP S565474 A JPS565474 A JP S565474A
Authority
JP
Japan
Prior art keywords
stirred
mixture
thf
added
styryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8086979A
Other languages
Japanese (ja)
Inventor
Hidehiko Oka
Akira Terahara
Motohiro Maruyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP8086979A priority Critical patent/JPS565474A/en
Publication of JPS565474A publication Critical patent/JPS565474A/en
Pending legal-status Critical Current

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  • Pyrane Compounds (AREA)

Abstract

NEW MATERIAL:4-Ethoxy-6-styryl-5,6-dihydro-2H-pyran-2-one of the formula.
USE: A preventive or remedy for hyperlipemia having an antilipemic action.
PROCESS: Ethyl acetoacetate is added dropwise to sodium hydride in anhydrous tetrahydrofuran (THF) under cooling with ice and stirring, and the mixture is stirred and then cooled at -10W-5°C. A solution of n-butyl lithium in n-hexane is added to the mixture, and cooled. Cinnamic aldehyde in an hydrous THF is added to the mixture into and stirred. The reaction mixture is then introduced ice water and stirred. After separating the THF layer, the aqueous layer is acidified with hydrochloric acid and extracted with ethyl acetate. The extract thus obtained is washed with saturated common salt solution, dried over sodium sulfate, and concentrated to give 6-styryl-2,4-dioxo-2H-pyran. The resulting compound is then mixed with diethyl sulfate and stirred. The reaction mixture is concentrated in vacuo, and the resulting residue is dissolved in water, acidified with hydrochloric acid, extracted with ethyl acetate, washed and dried to afford the compound of the formula.
COPYRIGHT: (C)1981,JPO&Japio
JP8086979A 1979-06-27 1979-06-27 4-ethoxy-2-pyrone derivative Pending JPS565474A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8086979A JPS565474A (en) 1979-06-27 1979-06-27 4-ethoxy-2-pyrone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8086979A JPS565474A (en) 1979-06-27 1979-06-27 4-ethoxy-2-pyrone derivative

Publications (1)

Publication Number Publication Date
JPS565474A true JPS565474A (en) 1981-01-20

Family

ID=13730342

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8086979A Pending JPS565474A (en) 1979-06-27 1979-06-27 4-ethoxy-2-pyrone derivative

Country Status (1)

Country Link
JP (1) JPS565474A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009023975A (en) * 2007-07-23 2009-02-05 Nagoya Industrial Science Research Inst Peroxisome proliferator-responsive receptor (PPAR) alpha ligand agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009023975A (en) * 2007-07-23 2009-02-05 Nagoya Industrial Science Research Inst Peroxisome proliferator-responsive receptor (PPAR) alpha ligand agent

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