JPS5697271A - Preparation of dihalogeno-5-trifluoromethylpyridine - Google Patents
Preparation of dihalogeno-5-trifluoromethylpyridineInfo
- Publication number
- JPS5697271A JPS5697271A JP17276279A JP17276279A JPS5697271A JP S5697271 A JPS5697271 A JP S5697271A JP 17276279 A JP17276279 A JP 17276279A JP 17276279 A JP17276279 A JP 17276279A JP S5697271 A JPS5697271 A JP S5697271A
- Authority
- JP
- Japan
- Prior art keywords
- halogeno
- dihalogeno
- trifluoromethylpyridine
- trifluoromethyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002140 halogenating effect Effects 0.000 abstract 3
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- YWOWJQMFMXHLQD-UHFFFAOYSA-N 3-(trifluoromethyl)pyridin-2-amine Chemical compound NC1=NC=CC=C1C(F)(F)F YWOWJQMFMXHLQD-UHFFFAOYSA-N 0.000 abstract 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
Abstract
PURPOSE: To obtain the titled substance in high yield, by halogenating trifluoromethyl-2-aminopyridine, reacting the halogenation product with a nitrite, and halogenating a 3-halogeno-5-trifluoromethylpyridone formed as a by-rpoduct.
CONSTITUTION: 2-Amino-5(or-3)-trifluoromethylpyridine is reacted with a halogenating agent in the presence of acetic, hydrochloric or hydrobromic acid to give a 2-amino-3-halogeno-5-trifluoromethyl(or 2-amino-3-trifluoromethyl-5-halogeno)pyridine, which is then reacted with a nitrite at -10W55°C to afford a 2,3-dihalogeno(or 3,6-dihalogeno)-5-trifluoromethylpyridine. The 3-halogeno-5-trifluoromethylpyridione formed as a by-product in the previous stage is further halogenated at 20W 150°C and converted into the aimed substance.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17276279A JPS5697271A (en) | 1979-12-28 | 1979-12-28 | Preparation of dihalogeno-5-trifluoromethylpyridine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17276279A JPS5697271A (en) | 1979-12-28 | 1979-12-28 | Preparation of dihalogeno-5-trifluoromethylpyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5697271A true JPS5697271A (en) | 1981-08-05 |
Family
ID=15947856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17276279A Pending JPS5697271A (en) | 1979-12-28 | 1979-12-28 | Preparation of dihalogeno-5-trifluoromethylpyridine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5697271A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4490534A (en) * | 1981-11-04 | 1984-12-25 | Ishihara Sangyo Kaisha Ltd. | Process for producing 3-chloro-5-trifluoromethylpyridines |
| WO2018186460A1 (en) * | 2017-04-04 | 2018-10-11 | 石原産業株式会社 | Method for purifying trifluoromethylpyridine compound |
-
1979
- 1979-12-28 JP JP17276279A patent/JPS5697271A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4490534A (en) * | 1981-11-04 | 1984-12-25 | Ishihara Sangyo Kaisha Ltd. | Process for producing 3-chloro-5-trifluoromethylpyridines |
| WO2018186460A1 (en) * | 2017-04-04 | 2018-10-11 | 石原産業株式会社 | Method for purifying trifluoromethylpyridine compound |
| US10882824B2 (en) | 2017-04-04 | 2021-01-05 | Ishihara Sangyo Kaisha, Ltd. | Method for purifying trifluoromethylpyridines |
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