JPS5724362A - Preparation of pindolol - Google Patents
Preparation of pindololInfo
- Publication number
- JPS5724362A JPS5724362A JP9845980A JP9845980A JPS5724362A JP S5724362 A JPS5724362 A JP S5724362A JP 9845980 A JP9845980 A JP 9845980A JP 9845980 A JP9845980 A JP 9845980A JP S5724362 A JPS5724362 A JP S5724362A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- indolyloxy
- compound
- compound shown
- lactisopropylamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 title 1
- 229960002508 pindolol Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 239000002994 raw material Substances 0.000 abstract 2
- CGIBIDSEBHNOQJ-UHFFFAOYSA-N 2-hydroxy-3-(1h-indol-4-yloxy)propanoic acid Chemical compound OC(=O)C(O)COC1=CC=CC2=C1C=CN2 CGIBIDSEBHNOQJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000219 Sympatholytic Substances 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- MOOAHMCRPCTRLV-UHFFFAOYSA-N boron sodium Chemical compound [B].[Na] MOOAHMCRPCTRLV-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- -1 e.g. Substances 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound useful as a β-sympatholytic agent in high purity and in high yield, by reducing β-(4-indolyloxy)lactisopropylamide as a raw material by a short process and simple operations.
CONSTITUTION: β-(4-Indolyloxy)lactisopropylamide shown by the formula I as a raw material is reduced in the presence of a reducing catalyst, e.g., aluminum borohydride, sodium boron hydride, etc. in an inert solvent, e.g., tetrahydrofuran, etc. at 0W50°C, preferably at 10W30°C, to give a compound shown by the formula II. The compound shown by the formula I is a novel compound, which is obtained by reacting a compound shown by the formula III with a compound shown by the formula IV to give novel β-(4-indolyloxy)lactic acid shown by the formula V, which is easily reacted with isopropylamine.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9845980A JPS5724362A (en) | 1980-07-17 | 1980-07-17 | Preparation of pindolol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9845980A JPS5724362A (en) | 1980-07-17 | 1980-07-17 | Preparation of pindolol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5724362A true JPS5724362A (en) | 1982-02-08 |
Family
ID=14220279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9845980A Pending JPS5724362A (en) | 1980-07-17 | 1980-07-17 | Preparation of pindolol |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5724362A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9346744B2 (en) * | 2014-08-28 | 2016-05-24 | Davuluri Ramamohan Rao | Process for the preparation of lacosamide and its novel intermediate |
-
1980
- 1980-07-17 JP JP9845980A patent/JPS5724362A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9346744B2 (en) * | 2014-08-28 | 2016-05-24 | Davuluri Ramamohan Rao | Process for the preparation of lacosamide and its novel intermediate |
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