JPS5770865A - Preparation of 5-aroylpyrrole-2-acetic acid derivative - Google Patents

Preparation of 5-aroylpyrrole-2-acetic acid derivative

Info

Publication number
JPS5770865A
JPS5770865A JP14728780A JP14728780A JPS5770865A JP S5770865 A JPS5770865 A JP S5770865A JP 14728780 A JP14728780 A JP 14728780A JP 14728780 A JP14728780 A JP 14728780A JP S5770865 A JPS5770865 A JP S5770865A
Authority
JP
Japan
Prior art keywords
compound expressed
methyl
formula
ethyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14728780A
Other languages
Japanese (ja)
Inventor
Hiroaki Kinugasa
Kaoru Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Janssen Pharmaceuticals Inc
Original Assignee
Dainippon Pharmaceutical Co Ltd
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd, McNeilab Inc filed Critical Dainippon Pharmaceutical Co Ltd
Priority to JP14728780A priority Critical patent/JPS5770865A/en
Publication of JPS5770865A publication Critical patent/JPS5770865A/en
Pending legal-status Critical Current

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  • Pyrrole Compounds (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as an anti-inflammatory agent in high yield, by reacting a novel compound as a starting substance with ammonia to an amine in the presence of water and an acid, and hydrolyzing the reaction product.
CONSTITUTION: A novel compound expressed by formulaI(Ar is p-tolyl or p- chlorophenyl; R1 is methyl or ethyl or together the other R1 may form ethylene or trimethylene; R2 is H or methyl; R3 is 1W6C alkyl; R4 is methyl or ethyl), e.g. methyl 5-(α,α-dimethoxy-p-methylbenzyl)-2,5-dimethoxytetrahydeofuran-2-acetate, is reacted with a compound expressed by the formula R5-NH2 (R5 is H, methyl or ethyl) in the presence of water and an acid to give a compound expressed by formula II, which is then hydrolyzed to afford the amied compound expressed by formula III. The compound expressed by formulaIis obtained by reacting a compound expressed by formula IV as a raw material with a compound expressed by the formula ArCOCl, converting the reaction product into a ketal, alkoxylating the ketal, and reducing the resultant alkoxylation product.
COPYRIGHT: (C)1982,JPO&Japio
JP14728780A 1980-10-20 1980-10-20 Preparation of 5-aroylpyrrole-2-acetic acid derivative Pending JPS5770865A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14728780A JPS5770865A (en) 1980-10-20 1980-10-20 Preparation of 5-aroylpyrrole-2-acetic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14728780A JPS5770865A (en) 1980-10-20 1980-10-20 Preparation of 5-aroylpyrrole-2-acetic acid derivative

Publications (1)

Publication Number Publication Date
JPS5770865A true JPS5770865A (en) 1982-05-01

Family

ID=15426782

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14728780A Pending JPS5770865A (en) 1980-10-20 1980-10-20 Preparation of 5-aroylpyrrole-2-acetic acid derivative

Country Status (1)

Country Link
JP (1) JPS5770865A (en)

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