JPS5829783A - チオフエンカルボン酸類の製造方法 - Google Patents

チオフエンカルボン酸類の製造方法

Info

Publication number: JPS5829783A
Authority: JP; Japan
Prior art keywords: hypohalite; reaction; aldehyde; expressed; added
Prior art date: 1981-08-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP12593881A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0261472B2 (cs

Inventor

Hiroshi Yano

宏谷野

Tetsuhiko Okamoto

岡本　哲彦

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Shin Nisson Kako Co Ltd

Original Assignee

Shin Nisson Kako Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-13

Filing date

1981-08-13

Publication date

1983-02-22

1981-08-13 Application filed by Shin Nisson Kako Co Ltd filed Critical Shin Nisson Kako Co Ltd

1981-08-13 Priority to JP12593881A priority Critical patent/JPS5829783A/ja

1983-02-22 Publication of JPS5829783A publication Critical patent/JPS5829783A/ja

1990-12-20 Publication of JPH0261472B2 publication Critical patent/JPH0261472B2/ja

Status Granted legal-status Critical Current

Links

QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 title abstract description 3
CNUDBTRUORMMPA-UHFFFAOYSA-N formylthiophene Chemical compound O=CC1=CC=CS1 CNUDBTRUORMMPA-UHFFFAOYSA-N 0.000 claims abstract description 8
239000012736 aqueous medium Substances 0.000 claims abstract description 6
229910052736 halogen Inorganic materials 0.000 claims abstract description 5
150000002367 halogens Chemical class 0.000 claims abstract description 5
125000000217 alkyl group Chemical group 0.000 claims abstract description 4
150000001299 aldehydes Chemical class 0.000 claims abstract 2
150000001875 compounds Chemical class 0.000 claims abstract 2
239000002253 acid Substances 0.000 claims description 9
238000004519 manufacturing process Methods 0.000 claims description 8
229910052739 hydrogen Inorganic materials 0.000 claims description 3
239000001257 hydrogen Substances 0.000 claims description 3
150000002431 hydrogen Chemical group 0.000 claims description 3
150000007513 acids Chemical class 0.000 claims description 2
238000007429 general method Methods 0.000 claims 1
238000006243 chemical reaction Methods 0.000 abstract description 35
239000000126 substance Substances 0.000 abstract description 13
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract description 12
239000005708 Sodium hypochlorite Substances 0.000 abstract description 5
SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 abstract description 5
238000000354 decomposition reaction Methods 0.000 abstract description 3
229930186147 Cephalosporin Natural products 0.000 abstract description 2
229940124587 cephalosporin Drugs 0.000 abstract description 2
150000001780 cephalosporins Chemical class 0.000 abstract description 2
230000003115 biocidal effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
238000003756 stirring Methods 0.000 description 10
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 6
239000000243 solution Substances 0.000 description 6
239000007864 aqueous solution Substances 0.000 description 5
-1 thiophene aldehydes Chemical class 0.000 description 5
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
239000007795 chemical reaction product Substances 0.000 description 4
239000000460 chlorine Substances 0.000 description 4
229910052801 chlorine Inorganic materials 0.000 description 4
WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 4
150000003839 salts Chemical class 0.000 description 4
229930192474 thiophene Natural products 0.000 description 4
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
238000000034 method Methods 0.000 description 3
239000000203 mixture Substances 0.000 description 3
230000001590 oxidative effect Effects 0.000 description 3
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
229910052783 alkali metal Inorganic materials 0.000 description 2
229910052784 alkaline earth metal Inorganic materials 0.000 description 2
239000013078 crystal Substances 0.000 description 2
125000005843 halogen group Chemical group 0.000 description 2
150000004679 hydroxides Chemical class 0.000 description 2
JGJLWPGRMCADHB-UHFFFAOYSA-N hypobromite Chemical compound Br[O-] JGJLWPGRMCADHB-UHFFFAOYSA-N 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000002994 raw material Substances 0.000 description 2
NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
WYJOVVXUZNRJQY-UHFFFAOYSA-N 2-Acetylthiophene Chemical compound CC(=O)C1=CC=CS1 WYJOVVXUZNRJQY-UHFFFAOYSA-N 0.000 description 1
ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
239000012029 Fehling's reagent Substances 0.000 description 1
238000005666 Myers alkylation reaction Methods 0.000 description 1
RHLLDTPGTFRJDJ-UHFFFAOYSA-N OCl.OCl Chemical compound OCl.OCl RHLLDTPGTFRJDJ-UHFFFAOYSA-N 0.000 description 1
OUYSIVYIKXCLTF-UHFFFAOYSA-N [C].S1C=CC=C1 Chemical group [C].S1C=CC=C1 OUYSIVYIKXCLTF-UHFFFAOYSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
150000001447 alkali salts Chemical class 0.000 description 1
150000001342 alkaline earth metals Chemical class 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
239000000920 calcium hydroxide Substances 0.000 description 1
229910001861 calcium hydroxide Inorganic materials 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
239000010931 gold Substances 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 1
QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000002609 medium Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
239000011707 mineral Substances 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
229910001923 silver oxide Inorganic materials 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Substances C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
239000002699 waste material Substances 0.000 description 1

Landscapes

Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

JP12593881A 1981-08-13 1981-08-13 チオフエンカルボン酸類の製造方法 Granted JPS5829783A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP12593881A JPS5829783A (ja)	1981-08-13	1981-08-13	チオフエンカルボン酸類の製造方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP12593881A JPS5829783A (ja)	1981-08-13	1981-08-13	チオフエンカルボン酸類の製造方法

Publications (2)

Publication Number	Publication Date
JPS5829783A true JPS5829783A (ja)	1983-02-22
JPH0261472B2 JPH0261472B2 (cs)	1990-12-20

Family

ID=14922675

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP12593881A Granted JPS5829783A (ja)	1981-08-13	1981-08-13	チオフエンカルボン酸類の製造方法

Country Status (1)

Country	Link
JP (1)	JPS5829783A (cs)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS63140089A (ja) *	1986-12-01	1988-06-11	Anelva Corp	アルミニウム合金膜のエツチング方法とその装置
CN101906092A (zh) *	2009-06-04	2010-12-08	浙江医药股份有限公司新昌制药厂	2-噻吩甲酸的制备方法
CN103232430A (zh) *	2013-04-30	2013-08-07	威海迪素制药有限公司	一种利伐沙班中间体5-氯噻吩-2-羧酸的制备方法
JP2023506917A (ja) *	2019-12-20	2023-02-20	バイエル・アクチエンゲゼルシヤフト	置換チオフェンカルボキサミド、チオフェンカルボン酸およびその誘導体

1981
- 1981-08-13 JP JP12593881A patent/JPS5829783A/ja active Granted

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS63140089A (ja) *	1986-12-01	1988-06-11	Anelva Corp	アルミニウム合金膜のエツチング方法とその装置
CN101906092A (zh) *	2009-06-04	2010-12-08	浙江医药股份有限公司新昌制药厂	2-噻吩甲酸的制备方法
CN103232430A (zh) *	2013-04-30	2013-08-07	威海迪素制药有限公司	一种利伐沙班中间体5-氯噻吩-2-羧酸的制备方法
JP2023506917A (ja) *	2019-12-20	2023-02-20	バイエル・アクチエンゲゼルシヤフト	置換チオフェンカルボキサミド、チオフェンカルボン酸およびその誘導体

Also Published As

Publication number	Publication date
JPH0261472B2 (cs)	1990-12-20

Publication	Publication Date	Title
JPS5829783A (ja)	1983-02-22	チオフエンカルボン酸類の製造方法
JPH11322722A (ja)	1999-11-24	オキソン酸カリウムの製造方法
CN104610093A (zh)	2015-05-13	苯肼的合成方法
KR910008936B1 (ko)	1991-10-26	2,4-디클로로-5-플루오로-벤조산의 제조방법
AU650172B2 (en)	1994-06-09	Chemical process
US4620042A (en)	1986-10-28	Preparation of 2-chloro-4-fluorophenol from 4-fluorophenol
US4614822A (en)	1986-09-30	Catalytic oxidation of 3,3-dimethyl-2-hydroxybutyric acid to 2-oxo acid and preparation of 4-amino-6-tert.-butyl-3-thio-1,2,4-triazine-5(4-H)-one
JP2002511797A (ja)	2002-04-16	モリブデンエポキシ化触媒の回収
US4582910A (en)	1986-04-15	Method for preparation of 4-halogenonaphthalic acid anhydrides
JPS59206335A (ja)	1984-11-22	６−クロル−２，４−ジニトロフエノ−ルの製造方法
US4220793A (en)	1980-09-02	Process for preparing a thiophene derivative
US4638099A (en)	1987-01-20	Method for making 4,4'-dihydroxydiphenyl ether
US6307009B1 (en)	2001-10-23	High catalyst phenolic resin binder system
JPH0632773A (ja)	1994-02-08	４，４’−チオビスベンゼンチオールの製造法
KR100517343B1 (ko)	2005-09-28	메톡시페닐하이드라진의 제조방법
JPH0138796B2 (cs)	1989-08-16
JP2591618B2 (ja)	1997-03-19	３，３―ビス―（４―ジメチルアミノフェニル）―６―ジメチルアミノフタリドの製造法
RU1798298C (ru)	1993-02-28	Способ получени серы
JP2002167349A (ja)	2002-06-11	４，４’−ジヒドロキシジフェニルエーテルの製造方法
JPS636269B2 (cs)	1988-02-09
JP2547089B2 (ja)	1996-10-23	カルボン酸類の製法
JPS6130556A (ja)	1986-02-12	２，４，６−トリフルオロ安息香酸の製造方法
JP2001261642A (ja)	2001-09-26	１−アルキルインドール−３−カルボン酸類の製造方法
JPH0211572A (ja)	1990-01-16	ヒドロキシキノリンカルボン酸の精製方法
CN120081759A (zh)	2025-06-03	一种非奈利酮关键中间体4-氰基-2-甲氧基苯甲醛的制备方法

JPS5829783A - チオフエンカルボン酸類の製造方法 - Google Patents

Info

Links

Landscapes

Priority Applications (1)

Applications Claiming Priority (1)

Publications (2)

Family

ID=14922675

Family Applications (1)

Country Status (1)

Cited By (4)

Cited By (4)

Also Published As

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