JPS5843365B2 - Hydrophilic poultice - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a hydrophilic poultice, which is an external skin patch used for anti-inflammatory and analgesic treatments, and particularly to improvements in its base.

Poultices can be used to treat lower back pain, neuralgia, rheumatism, stiff shoulders, bruises,
This is a preparation that has been used for a long time to treat sprains and other conditions.

Poultices are made by mixing herbal medicines such as active ingredients methyl salicylate, camphor, and menthol in a plaster base.

The composition, production, etc. of such poultices are disclosed in numerous documents.

However, these conventional poultices commercially available or known in the literature have disadvantages related to storage, such as separation of humectants, medicinal ingredients, water, etc., which occur when stored for a long period of time, and the disadvantages of poultices especially in summer and during sweating. There are disadvantages related to use, such as softening of the poultice itself, residual poultices on the skin, and solidification of poultices when applied for a long period of time.

To date, in order to prevent such drawbacks, especially softening at high temperatures, alkaline earth metals and metal salts of divalent or higher valence, epoxy compounds, boric acid and boron compounds, and various aldehydes such as formalin and dialdehyde starch have been used. Additions of compounds and ketones have been used.

However, the addition of divalent or higher-valent metal salts reacts with other gelling agents, leading to the occurrence of agglomeration, which tends to increase the separation of water, etc. from the poultice.

Furthermore, the addition of epoxy compounds, boron compounds, aldehydes, and ketones poses safety problems since poultices are products that are applied directly to human skin.

An object of the present invention is to solve the above-mentioned problems without causing such drawbacks, and to improve the commercial value of poultices.

That is, the present invention resides in a hydrophilic poultice agent characterized in that magnesium aluminate metasilicate is added to a base for a hydrophilic poultice agent.

That is, the inventors have confirmed through research that the above-mentioned problems, which were conventionally considered unavoidable, can be greatly improved by adding magnesium aluminate metasilicate.

The magnesium aluminate metasilicate used according to the invention is Al2O3.Mg0.2 S 102.xH2O
It is generally used as a drug for the treatment of gastric hyperacidity, gastric catarrh, gastric ulcer, etc., and as an excipient, glidant, molding agent, and adsorbent powder in the formulation process of tablets, powders, granules, capsules, etc. It is widely used as a chemical agent and is completely safe for humans.

Furthermore, since this compound is composed of aluminum in the form of aluminic acid, it is clearly distinguished from cationic aluminum compounds such as alum and aluminum sulfate in terms of its properties.

The composition of the plaster base constituting the poultice of the present invention other than magnesium aluminate metasilicate is the same as that of conventional ones, and the best powder component is kaolin, and the wetting agents are glycerin and polyethylene glycol. As the adhesive gelling agent, sodium polyacrylate, gelatin, carrageenan, carboxymethyl cellulose, etc. can be used.

Preferably, magnesium aluminate metasilicate is added in an amount of 0.3 to 1.5% of the total weight ratio.

Among them, the specific examples described below are effective prescription examples when commercial value is taken into consideration.

Preferred embodiments of the present invention will be described in detail below, but the present invention is not limited thereto.

Example 1 10 parts of kaolin, magnesium aluminate metasilicate (
Put 0.3 parts of inocillin UFL2), 3 parts of sodium polyacrylate, and 0.5 parts of carboxymethyl cellulose into a mixer, gradually add 28.5 parts of glycerin, and mix thoroughly until it becomes paste-like.

Separately, 4.5 parts of gelatin is swollen with 50 parts of water, dissolved at 50 to 60°C, and added to the paste and mixed uniformly.

This was cooled to 35°C to 40°C, and then 0.9 parts of sorbitan fatty acid ester and medicinal ingredients were added.
Mix until everything is homogeneous.

The medicinal ingredients are 1 part methyl salicylate, 1 part camphor, l-
It is 0.5 part of menthol.

Next, this poultice was spread on a nonwoven fabric to a certain thickness using a spreading machine, the surface was covered with a polyethylene film, and the product was cut into a - area to obtain a poultice preparation.

In the poultice preparation thus obtained, the poultice does not soften even in high temperature ranges and during sweating.
Even when it was applied for a long time, it did not lose its cooling sensation, adhesion, or flexibility, and no solidification or separation phenomena were observed.

In order to clarify the effect of adding magnesium aluminate metasilicate according to the present invention, a poultice prepared by excluding magnesium aluminate metasilicate from the above composition,
A comparative test was conducted on two types of poultices currently on the market.

As an abuse condition for comparison, each bag of poultice was placed in a constant temperature chamber adjusted to 35°C and 45°C (±2°C), and taken out every day (24 hours) until the temperature of the drug reached room temperature. Check whether there is any oozing or stickiness from the non-woven fabric before it returns, whether the poultice sticks to the polyethylene film when it is peeled off, and whether the poultice sticks to the skin when the poultice is strongly pressed against the skin and then removed. Evaluation was performed on four items: whether or not there was any residual poultice.

The results at 35°C are shown in Table 1, and the results at 45°C are shown in Table 2.

Sample I is a poultice containing magnesium aluminate metasilicate according to the present invention, Samples ■ and l are two different commercially available poultices, and Sample ■ is the same composition as the poultice of Sample I but excludes magnesium aluminate metasilicate. This figure shows a poultice prepared as follows.

In the table, - means not at all, shi means a small amount, + means a small amount, masu means a large amount, and kan means a considerably large amount.

As is clear from these tables, the poultice of the present invention exhibited very superior physical properties compared to others.

Example 2 In the same manner as in Example 1, 1.0 or more l of methyl salicylate was added.
J-Me7 To/110.5%, camphor 1.0 kaolin 9.0%, magnesium aluminate metasilicate 0.8%, sodium polyacrylate 4.0%, carrageenan 0.5%, gelatin 4 .0%, glycerin 3
A poultice was prepared from a composition consisting of 0.0% sorbitan fatty acid ester, 0.8φ of sorbitan fatty acid ester, and an appropriate amount of ordinary water.

In this case as well, similar results to those of the poultice of Example 1 were shown.

Example 3 In the same manner as in Example 1, 1.0 k, l of methyl salicylate
-0.5 parts of menthol, 1.0 parts of camphor, 8 parts of kaolin
．． Article 0, magnesium aluminate metasilicate 1.20/
), sodium polyacrylate 3.0φ, gelatin 3.
A poultice was prepared from the following composition: 5 tons, 30.0% glycerin, 0.9% sorbitan fatty acid ester, and an appropriate amount of ordinary water.

In this case as well, similar to the poultice of Example 1, good results were shown.

Although the present invention has been described above in detail with reference to specific examples, the present invention is not limited to these specific examples, and it goes without saying that many changes and modifications can be made without departing from the spirit of the invention.

Claims (1)

[Claims] 1. A hydrophilic poultice agent characterized in that magnesium aluminate metasilicate is added to a base for a hydrophilic poultice agent.