JPS5874619A - リポソ−ム及びその製法 - Google Patents

リポソ−ム及びその製法

Info

Publication number: JPS5874619A
Authority: JP; Japan
Prior art keywords: liposome; steryl; tidyl; phosph; purine
Prior art date: 1981-10-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP56173944A

Other languages

English (en)

Japanese (ja)

Inventor

Masanobu Kawamata

川真田　正信

Koichi Ushimaru

牛丸　紘一

Shuji Yamane

山根　周二

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nippon Shinyaku Co Ltd

Original Assignee

Nippon Shinyaku Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-10-29

Filing date

1981-10-29

Publication date

1983-05-06

1981-10-29 Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd

1981-10-29 Priority to JP56173944A priority Critical patent/JPS5874619A/ja

1982-09-08 Priority to KR1019820004068A priority patent/KR840001278A/ko

1983-03-07 Priority to GB08306237A priority patent/GB2135878B/en

1983-03-14 Priority to DE3309076A priority patent/DE3309076C2/de

1983-03-18 Priority to BE0/210362A priority patent/BE896217A/fr

1983-03-21 Priority to CH1532/83A priority patent/CH658001A5/de

1983-03-21 Priority to FR8304592A priority patent/FR2542999B1/fr

1983-05-06 Publication of JPS5874619A publication Critical patent/JPS5874619A/ja

Status Pending legal-status Critical Current

Links

239000002502 liposome Substances 0.000 title claims description 31
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 23
229930182478 glucoside Natural products 0.000 claims description 19
150000008131 glucosides Chemical class 0.000 claims description 19
150000002632 lipids Chemical class 0.000 claims description 9
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 7
239000000126 substance Substances 0.000 claims description 7
JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical group CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 claims description 4
229930182558 Sterol Natural products 0.000 claims description 4
LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
-1 phosphatidyl phosphorus Chemical compound 0.000 claims description 4
150000003432 sterols Chemical class 0.000 claims description 4
235000003702 sterols Nutrition 0.000 claims description 4
238000003756 stirring Methods 0.000 claims description 4
OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 claims description 3
BLKPFVWYBFDTPX-UHFFFAOYSA-N 2-(6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl)acetaldehyde Chemical compound C1C2C(C)(C)C1CC=C2CC=O BLKPFVWYBFDTPX-UHFFFAOYSA-N 0.000 claims description 3
OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 claims description 3
240000008607 Opuntia megacantha Species 0.000 claims description 3
235000002840 Opuntia megacantha Nutrition 0.000 claims description 3
235000006538 Opuntia tuna Nutrition 0.000 claims description 3
HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 claims description 3
239000002253 acid Substances 0.000 claims description 3
239000004480 active ingredient Substances 0.000 claims description 3
239000003795 chemical substances by application Substances 0.000 claims description 3
235000012000 cholesterol Nutrition 0.000 claims description 3
NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 claims description 3
239000003381 stabilizer Substances 0.000 claims description 3
HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 claims description 3
235000016831 stigmasterol Nutrition 0.000 claims description 3
229940032091 stigmasterol Drugs 0.000 claims description 3
BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 claims description 3
SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 claims description 2
BTEISVKTSQLKST-UHFFFAOYSA-N Haliclonasterol Natural products CC(C=CC(C)C(C)(C)C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C BTEISVKTSQLKST-UHFFFAOYSA-N 0.000 claims description 2
SGNBVLSWZMBQTH-PODYLUTMSA-N campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 claims description 2
235000000431 campesterol Nutrition 0.000 claims description 2
RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical group CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 claims description 2
229940093541 dicetylphosphate Drugs 0.000 claims description 2
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 6
REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical group CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 claims 1
229940076810 beta sitosterol Drugs 0.000 claims 1
NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 claims 1
229940107161 cholesterol Drugs 0.000 claims 1
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
XXOYNJXVWVNOOJ-UHFFFAOYSA-N fenuron Chemical compound CN(C)C(=O)NC1=CC=CC=C1 XXOYNJXVWVNOOJ-UHFFFAOYSA-N 0.000 claims 1
230000001678 irradiating effect Effects 0.000 claims 1
229910052698 phosphorus Inorganic materials 0.000 claims 1
239000011574 phosphorus Substances 0.000 claims 1
KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 claims 1
229950005143 sitosterol Drugs 0.000 claims 1
238000002347 injection Methods 0.000 description 18
239000007924 injection Substances 0.000 description 18
239000000243 solution Substances 0.000 description 17
239000003814 drug Substances 0.000 description 16
239000000203 mixture Substances 0.000 description 16
229940079593 drug Drugs 0.000 description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
150000001875 compounds Chemical class 0.000 description 10
238000000034 method Methods 0.000 description 9
241000196324 Embryophyta Species 0.000 description 7
235000002597 Solanum melongena Nutrition 0.000 description 6
239000002904 solvent Substances 0.000 description 6
244000061458 Solanum melongena Species 0.000 description 5
230000001954 sterilising effect Effects 0.000 description 5
238000004659 sterilization and disinfection Methods 0.000 description 5
239000007789 gas Substances 0.000 description 4
230000023597 hemostasis Effects 0.000 description 4
239000000463 material Substances 0.000 description 4
230000000144 pharmacologic effect Effects 0.000 description 4
150000003904 phospholipids Chemical class 0.000 description 4
239000003708 ampul Substances 0.000 description 3
239000003125 aqueous solvent Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
238000005516 engineering process Methods 0.000 description 3
239000000787 lecithin Substances 0.000 description 3
235000010445 lecithin Nutrition 0.000 description 3
KILNVBDSWZSGLL-UHFFFAOYSA-O 2-[2,3-di(hexadecanoyloxy)propoxy-hydroxyphosphoryl]oxyethyl-trimethylazanium Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-UHFFFAOYSA-O 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
244000068988 Glycine max Species 0.000 description 2
235000010469 Glycine max Nutrition 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
210000004204 blood vessel Anatomy 0.000 description 2
239000007853 buffer solution Substances 0.000 description 2
239000012528 membrane Substances 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
239000002994 raw material Substances 0.000 description 2
230000002787 reinforcement Effects 0.000 description 2
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
229920003026 Acene Polymers 0.000 description 1
241000234282 Allium Species 0.000 description 1
240000000560 Citrus x paradisi Species 0.000 description 1
206010010071 Coma Diseases 0.000 description 1
229930186291 Dulcoside Natural products 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
241000087799 Koma Species 0.000 description 1
244000046052 Phaseolus vulgaris Species 0.000 description 1
235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
VWDLOXMZIGUBKM-PLWLBJPKSA-N Stigmasteryl glucoside Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@H]1OC(CO)[C@@H](O)C(O)C1O VWDLOXMZIGUBKM-PLWLBJPKSA-N 0.000 description 1
239000012190 activator Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
239000003513 alkali Substances 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
FSMCJUNYLQOAIM-UQBZCTSOSA-N cholesteryl beta-D-glucoside Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O FSMCJUNYLQOAIM-UQBZCTSOSA-N 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000010828 elution Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
238000001914 filtration Methods 0.000 description 1
150000002270 gangliosides Chemical class 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
239000007788 liquid Substances 0.000 description 1
206010025482 malaise Diseases 0.000 description 1
230000007721 medicinal effect Effects 0.000 description 1
229910000403 monosodium phosphate Inorganic materials 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
229940042880 natural phospholipid Drugs 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000012454 non-polar solvent Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
230000003014 reinforcing effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000000523 sample Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000002328 sterol group Chemical group 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000010409 thin film Substances 0.000 description 1
LZGVDNRJCGPNDS-UHFFFAOYSA-N trinitromethane Chemical compound [O-][N+](=O)C([N+]([O-])=O)[N+]([O-])=O LZGVDNRJCGPNDS-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229910000406 trisodium phosphate Inorganic materials 0.000 description 1
235000019801 trisodium phosphate Nutrition 0.000 description 1
238000005199 ultracentrifugation Methods 0.000 description 1
230000002792 vascular Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Dispersion Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Manufacturing Of Micro-Capsules (AREA)

JP56173944A 1981-10-29 1981-10-29 リポソ−ム及びその製法 Pending JPS5874619A (ja)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
JP56173944A JPS5874619A (ja)	1981-10-29	1981-10-29	リポソ−ム及びその製法
KR1019820004068A KR840001278A (ko)	1981-10-29	1982-09-08	리보소음의 제법
GB08306237A GB2135878B (en)	1981-10-29	1983-03-07	Liposome containing steryl glycoside
DE3309076A DE3309076C2 (de)	1981-10-29	1983-03-14	Liposome und Verfahren zu ihrer Herstellung
BE0/210362A BE896217A (fr)	1981-10-29	1983-03-18	Liposomes et procede pour les preparer
CH1532/83A CH658001A5 (de)	1981-10-29	1983-03-21	Liposom.
FR8304592A FR2542999B1 (fr)	1981-10-29	1983-03-21	Procede de fabrication de liposome contenant un ou plusieurs sterylglucosides et monopalmitates de sterylglucosides et nouveaux produits ainsi obtenus

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP56173944A JPS5874619A (ja)	1981-10-29	1981-10-29	リポソ−ム及びその製法

Publications (1)

Publication Number	Publication Date
JPS5874619A true JPS5874619A (ja)	1983-05-06

Family

ID=15969954

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP56173944A Pending JPS5874619A (ja)	1981-10-29	1981-10-29	リポソ−ム及びその製法

Country Status (7)

Country	Link
JP (1)	JPS5874619A (de)
KR (1)	KR840001278A (de)
BE (1)	BE896217A (de)
CH (1)	CH658001A5 (de)
DE (1)	DE3309076C2 (de)
FR (1)	FR2542999B1 (de)
GB (1)	GB2135878B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002526399A (ja) *	1998-10-02	2002-08-20	アイジェンインコーポレイテッド	グルコシドパウキラメラベシクル

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4107153A1 (de) *	1991-03-06	1992-09-10	Gregor Cevc	Praeparat zur wirkstoffapplikation in kleinsttroepfchenform
DE4107152C2 (de) *	1991-03-06	1994-03-24	Gregor Cevc	Präparate zur nichtinvasiven Verabreichung von Antidiabetica
US20070196436A1 (en) *	2006-02-23	2007-08-23	Conopco, Inc., D/B/A Unilever	Process for preparing an edible composition comprising steroidal glycosides
US10251839B2 (en)	2008-01-22	2019-04-09	Igi Laboratories, Inc.	Lipid vesicles derived from olive oil fatty acids
US9775853B2 (en)	2013-03-15	2017-10-03	Biomet Manufacturing, Llc.	Hemostatic compositions and methods

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA72698B (en) *	1972-02-03	1973-09-26	Liebenberg R W	Method of preparing medicinal compositions
US3966918A (en) *	1973-12-12	1976-06-29	Nippon Shinyaku Co., Ltd.	Method of preparing aqueous solutions of sterol glycosides and their ester derivatives
JPS51139613A (en) *	1975-05-24	1976-12-02	Nippon Shinyaku Co Ltd	An absorbable non-crystalline sterol glycoside monopalmitate ester and a method for preparing its pharmaceutical
GB1491549A (en) *	1975-05-26	1977-11-09	Nippon Shinyaku Co Ltd	Haemostatics vascular stabilisers and anti-shock agents
DE2759171A1 (de) *	1977-12-31	1979-07-12	Roecar Holdings Nv	Arzneimittel mit wirkung als prostaglandinsynthetaseninhibitor
SE7900458L (sv) *	1978-01-27	1979-07-28	Sandoz Ag	Liposom-avgivningssystem for lekemedel
US4254111A (en) *	1978-07-05	1981-03-03	Roecar Holdings (Netherlands Antilles) Nv	Sterolin products
US4310505A (en) *	1979-11-08	1982-01-12	California Institute Of Technology	Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances

1981
- 1981-10-29 JP JP56173944A patent/JPS5874619A/ja active Pending
1982
- 1982-09-08 KR KR1019820004068A patent/KR840001278A/ko not_active Ceased
1983
- 1983-03-07 GB GB08306237A patent/GB2135878B/en not_active Expired
- 1983-03-14 DE DE3309076A patent/DE3309076C2/de not_active Expired
- 1983-03-18 BE BE0/210362A patent/BE896217A/fr not_active IP Right Cessation
- 1983-03-21 CH CH1532/83A patent/CH658001A5/de not_active IP Right Cessation
- 1983-03-21 FR FR8304592A patent/FR2542999B1/fr not_active Expired

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002526399A (ja) *	1998-10-02	2002-08-20	アイジェンインコーポレイテッド	グルコシドパウキラメラベシクル
JP4820002B2 (ja) *	1998-10-02	2011-11-24	アイジェンインコーポレイテッド	グルコシドパウキラメラベシクル

Also Published As

Publication number	Publication date
FR2542999A1 (fr)	1984-09-28
DE3309076A1 (de)	1984-09-20
CH658001A5 (de)	1986-10-15
GB2135878B (en)	1987-07-22
GB2135878A (en)	1984-09-12
GB8306237D0 (en)	1983-04-13
KR840001278A (ko)	1984-04-30
FR2542999B1 (fr)	1987-09-25
DE3309076C2 (de)	1986-06-12
BE896217A (fr)	1983-07-18

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