JPS5912139B2 - 免疫学的試験方法 - Google Patents

免疫学的試験方法

Info

Publication number: JPS5912139B2
Authority: JP; Japan
Prior art keywords: reactance; test; receptor; particles; label
Prior art date: 1977-11-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP53134678A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5491296A (en

Inventor

リチヤ−ド・カルビン・エバ−ソ−ル

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

EIDP Inc

Original Assignee

EI Du Pont de Nemours and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-11-03

Filing date

1978-11-02

Publication date

1984-03-21

1978-09-18 Priority claimed from US05/942,261 external-priority patent/US4219335A/en

1978-11-02 Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co

1979-07-19 Publication of JPS5491296A publication Critical patent/JPS5491296A/ja

1984-03-21 Publication of JPS5912139B2 publication Critical patent/JPS5912139B2/ja

Status Expired legal-status Critical Current

Links

230000001900 immune effect Effects 0.000 title claims description 6
238000010998 test method Methods 0.000 title 1
238000012360 testing method Methods 0.000 claims description 54
239000003153 chemical reaction reagent Substances 0.000 claims description 30
238000000034 method Methods 0.000 claims description 23
230000005291 magnetic effect Effects 0.000 claims description 20
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PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 10
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 9
150000001875 compounds Chemical class 0.000 claims description 8
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239000010941 cobalt Substances 0.000 claims description 4
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 4
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VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 2
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239000011651 chromium Substances 0.000 claims description 2
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PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims 1
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239000013078 crystal Substances 0.000 description 2
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SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
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NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
241000283707 Capra Species 0.000 description 1
102000014914 Carrier Proteins Human genes 0.000 description 1
108010078791 Carrier Proteins Proteins 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
229910052693 Europium Inorganic materials 0.000 description 1
102000006395 Globulins Human genes 0.000 description 1
108010044091 Globulins Proteins 0.000 description 1
230000005355 Hall effect Effects 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
102000004856 Lectins Human genes 0.000 description 1
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BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 1
229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
102000002248 Thyroxine-Binding Globulin Human genes 0.000 description 1
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239000002253 acid Substances 0.000 description 1
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229910000828 alnico Inorganic materials 0.000 description 1
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XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
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239000005387 chalcogenide glass Substances 0.000 description 1
150000004770 chalcogenides Chemical class 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
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238000009833 condensation Methods 0.000 description 1
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229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
239000011162 core material Substances 0.000 description 1
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238000010168 coupling process Methods 0.000 description 1
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239000002359 drug metabolite Substances 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
230000005294 ferromagnetic effect Effects 0.000 description 1
230000005307 ferromagnetism Effects 0.000 description 1
239000012634 fragment Substances 0.000 description 1
208000005252 hepatitis A Diseases 0.000 description 1
208000002672 hepatitis B Diseases 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
230000003100 immobilizing effect Effects 0.000 description 1
230000003053 immunization Effects 0.000 description 1
230000000984 immunochemical effect Effects 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
230000036046 immunoreaction Effects 0.000 description 1
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239000010954 inorganic particle Substances 0.000 description 1
239000002523 lectin Substances 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
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229910000480 nickel oxide Inorganic materials 0.000 description 1
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GNRSAWUEBMWBQH-UHFFFAOYSA-N oxonickel Chemical compound [Ni]=O GNRSAWUEBMWBQH-UHFFFAOYSA-N 0.000 description 1
NRNFFDZCBYOZJY-UHFFFAOYSA-N p-quinodimethane Chemical compound C=C1C=CC(=C)C=C1 NRNFFDZCBYOZJY-UHFFFAOYSA-N 0.000 description 1
239000013610 patient sample Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
238000009597 pregnancy test Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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239000012857 radioactive material Substances 0.000 description 1
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238000009589 serological test Methods 0.000 description 1
239000002689 soil Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000009600 syphilis test Methods 0.000 description 1
PCCVSPMFGIFTHU-UHFFFAOYSA-N tetracyanoquinodimethane Chemical compound N#CC(C#N)=C1C=CC(=C(C#N)C#N)C=C1 PCCVSPMFGIFTHU-UHFFFAOYSA-N 0.000 description 1
XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
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LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles

Landscapes

Health & Medical Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

JP53134678A 1977-11-03 1978-11-02 免疫学的試験方法 Expired JPS5912139B2 (ja)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US84821777A	1977-11-03	1977-11-03
US000000848217		1977-11-03
US05/942,261 US4219335A (en)	1978-09-18	1978-09-18	Immunochemical testing using tagged reagents
US000000942261		1978-09-18

Publications (2)

Publication Number	Publication Date
JPS5491296A JPS5491296A (en)	1979-07-19
JPS5912139B2 true JPS5912139B2 (ja)	1984-03-21

Family

ID=27126757

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP53134678A Expired JPS5912139B2 (ja)	1977-11-03	1978-11-02	免疫学的試験方法

Country Status (16)

Country	Link
JP (1)	JPS5912139B2 (da)
AU (1)	AU522995B2 (da)
CA (1)	CA1122503A (da)
CH (1)	CH638052A5 (da)
DE (1)	DE2847282A1 (da)
DK (1)	DK489678A (da)
FI (1)	FI783346A7 (da)
FR (1)	FR2408142A1 (da)
GB (1)	GB2008767B (da)
IE (1)	IE47482B1 (da)
IL (1)	IL55856A (da)
IT (1)	IT1101280B (da)
LU (1)	LU80471A1 (da)
NL (1)	NL7810910A (da)
NO (1)	NO151099C (da)
SE (1)	SE431257B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2136130B (en) *	1983-02-28	1987-02-11	Theodore Henry Krueger	Chemical assay systems and methods
CA1220818A (en) *	1983-05-05	1987-04-21	Hugh A.O. Hill	Assay techniques utilising specific binding agents
GB8314523D0 (en) *	1983-05-25	1983-06-29	Lowe C R	Diagnostic device
EP0139373A1 (en) *	1983-08-26	1985-05-02	The Regents Of The University Of California	Multiple immunoassay system
JPS6055265A (ja) *	1983-09-06	1985-03-30	Fujirebio Inc	磁性粒子を用いた抗原、抗体の測定方法
GB8331514D0 (en) *	1983-11-25	1984-01-04	Janssen Pharmaceutica Nv	Visualization method
AU596946B2 (en) *	1984-07-10	1990-05-24	F. Hoffmann-La Roche Ltd	Methods of assay
FI844027A7 (fi) *	1984-10-12	1986-04-13	Labsystems Oy	Immunologiskt bestaemningsfoerfarande.
JPH0823558B2 (ja) *	1984-11-27	1996-03-06	オ−ジエニクスリミテツド	検定装置
LU86239A1 (fr) *	1986-01-02	1987-09-03	Sanders Probel Lab	Methode de detection d'agents reactifs et moyens de mise en oeuvre de cette methode
US4794089A (en) *	1986-03-25	1988-12-27	Midwest Research Microscopy, Inc.	Method for electronic detection of a binding reaction
US5374524A (en) *	1988-05-10	1994-12-20	E. I. Du Pont De Nemours And Company	Solution sandwich hybridization, capture and detection of amplified nucleic acids
US5137804A (en) *	1988-05-10	1992-08-11	E. I. Du Pont De Nemours And Company	Assay device and immunoassay
GB2270976A (en) *	1992-09-18	1994-03-30	Marconi Gec Ltd	Immunoassay/separation process using an auxiliary species on a support
RU2225985C2 (ru) *	1998-09-08	2004-03-20	Тиботек Н.В.	Способ быстрого скрининга анализируемых проб
US6544480B1 (en)	1999-10-26	2003-04-08	Tibotec Bvba	Device and related method for dispensing small volumes of liquid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1479661A (en) *	1972-06-26	1977-07-13	Gen Electric	Method and apparatus for detection and purification of proteins and antibodies
GB1500127A (en) *	1973-10-10	1978-02-08	Abbott Lab	Reactive matrices
US4020151A (en) *	1976-02-17	1977-04-26	International Diagnostic Technology, Inc.	Method for quantitation of antigens or antibodies on a solid surface
IL49685A (en) *	1976-05-31	1978-10-31	Technion Res & Dev Foundation	Specific binding assay method for determining the concentration of materials and reagent means therefor
US4087248A (en) *	1976-07-26	1978-05-02	Miles Laughton E	Multiple assay machine and method

1978
- 1978-10-03 SE SE7810351A patent/SE431257B/sv not_active IP Right Cessation
- 1978-10-31 DE DE19782847282 patent/DE2847282A1/de not_active Withdrawn
- 1978-10-31 CA CA315,018A patent/CA1122503A/en not_active Expired
- 1978-11-01 GB GB7842707A patent/GB2008767B/en not_active Expired
- 1978-11-01 CH CH1125478A patent/CH638052A5/de not_active IP Right Cessation
- 1978-11-02 IL IL55856A patent/IL55856A/xx unknown
- 1978-11-02 FR FR7831041A patent/FR2408142A1/fr active Granted
- 1978-11-02 AU AU41283/78A patent/AU522995B2/en not_active Expired
- 1978-11-02 IE IE2168/78A patent/IE47482B1/en unknown
- 1978-11-02 IT IT7829378A patent/IT1101280B/it active
- 1978-11-02 FI FI783346A patent/FI783346A7/fi unknown
- 1978-11-02 JP JP53134678A patent/JPS5912139B2/ja not_active Expired
- 1978-11-02 DK DK489678A patent/DK489678A/da not_active Application Discontinuation
- 1978-11-02 NL NL7810910A patent/NL7810910A/xx not_active Application Discontinuation
- 1978-11-02 NO NO783691A patent/NO151099C/no unknown
- 1978-11-03 LU LU80471A patent/LU80471A1/xx unknown

Also Published As

Publication number	Publication date
JPS5491296A (en)	1979-07-19
NL7810910A (nl)	1979-05-07
FR2408142A1 (fr)	1979-06-01
IE47482B1 (en)	1984-04-04
FR2408142B1 (da)	1984-02-17
CA1122503A (en)	1982-04-27
NO151099B (no)	1984-10-29
GB2008767B (en)	1982-06-30
NO783691L (no)	1979-05-04
SE7810351L (sv)	1979-05-04
DE2847282A1 (de)	1979-05-10
SE431257B (sv)	1984-01-23
IL55856A0 (en)	1979-01-31
IT1101280B (it)	1985-09-28
DK489678A (da)	1979-05-04
LU80471A1 (fr)	1979-06-15
AU522995B2 (en)	1982-07-08
IT7829378A0 (it)	1978-11-02
IE782168L (en)	1980-03-18
FI783346A7 (fi)	1979-05-04
NO151099C (no)	1985-02-06
GB2008767A (en)	1979-06-06
CH638052A5 (de)	1983-08-31
AU4128378A (en)	1979-05-17
IL55856A (en)	1981-11-30

Publication	Publication Date	Title
US4219335A (en)	1980-08-26	Immunochemical testing using tagged reagents
JP4324212B2 (ja)	2009-09-02	磁気応答性試薬を使用する磁気補助結合アッセイ
Richardson et al.	2001	The use of coated paramagnetic particles as a physical label in a magneto-immunoassay
JPS5912139B2 (ja)	1984-03-21	免疫学的試験方法
US6294342B1 (en)	2001-09-25	Magnetically assisted binding assays utilizing a magnetically responsive reagent
EP0631669B1 (en)	2004-07-14	Magnetically assisted binding assays using magnetically-labeled binding members
SE443660B (sv)	1986-03-03	Forfarande och reagens for immunanalys med rf eller clq adsorberat till fast berare
JPH10513551A (ja)	1998-12-22	被検体の磁気緩和測定での検出のための方法及び化合物並びにそれらの使用
JPH0562302B2 (da)	1993-09-08
US4138213A (en)	1979-02-06	Agglutination immunoassay of immune complex with RF or Clq
EP0631668B1 (en)	2002-09-04	Determination of binding affinity using magnetically-labeled binding members
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