JPS59204159A - 〔Ｍｅｔ（Ｏ）↑８’↑１↑８〕ｈＰＴＨ−（１−３４）ペプチド - Google Patents

〔Ｍｅｔ（Ｏ）↑８’↑１↑８〕ｈＰＴＨ−（１−３４）ペプチド

Info

Publication number: JPS59204159A
Authority: JP; Japan
Prior art keywords: peptide; leu; met; group; glu
Prior art date: 1983-04-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP58075607A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0314320B2 (da

Inventor

Shigeo Kuzuki

葛木　茂夫

Ko Morita

森田　香

Hiroshi Matsunaga

浩松永

Toshio Matsumoto

俊夫松本

Etsuro Ogata

尾形　悦郎

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Toyo Jozo KK

Original Assignee

Toyo Jozo KK

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-28

Filing date

1983-04-28

Publication date

1984-11-19

1983-04-28 Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK

1983-04-28 Priority to JP58075607A priority Critical patent/JPS59204159A/ja

1984-11-19 Publication of JPS59204159A publication Critical patent/JPS59204159A/ja

1991-02-26 Publication of JPH0314320B2 publication Critical patent/JPH0314320B2/ja

Status Granted legal-status Critical Current

Links

108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 30
150000003839 salts Chemical class 0.000 claims abstract description 6
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 13
229910052791 calcium Inorganic materials 0.000 abstract description 13
239000011575 calcium Substances 0.000 abstract description 13
108010049264 Teriparatide Proteins 0.000 abstract description 9
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
238000007254 oxidation reaction Methods 0.000 abstract description 3
230000003647 oxidation Effects 0.000 abstract description 2
210000002700 urine Anatomy 0.000 abstract description 2
239000003814 drug Substances 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
230000001590 oxidative effect Effects 0.000 abstract 1
230000001603 reducing effect Effects 0.000 abstract 1
230000002485 urinary effect Effects 0.000 description 19
239000008280 blood Substances 0.000 description 15
210000004369 blood Anatomy 0.000 description 15
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 13
229910052698 phosphorus Inorganic materials 0.000 description 13
239000011574 phosphorus Substances 0.000 description 13
150000001413 amino acids Chemical class 0.000 description 11
230000000694 effects Effects 0.000 description 11
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 9
238000000034 method Methods 0.000 description 9
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 7
125000006239 protecting group Chemical group 0.000 description 7
239000000243 solution Substances 0.000 description 7
102000004196 processed proteins & peptides Human genes 0.000 description 6
239000002253 acid Substances 0.000 description 5
238000006482 condensation reaction Methods 0.000 description 4
150000002148 esters Chemical class 0.000 description 4
-1 inorganic acid salts Chemical class 0.000 description 4
238000005259 measurement Methods 0.000 description 4
OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
229920005654 Sephadex Polymers 0.000 description 3
239000012507 Sephadex™ Substances 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
238000009833 condensation Methods 0.000 description 3
230000005494 condensation Effects 0.000 description 3
210000001105 femoral artery Anatomy 0.000 description 3
210000003734 kidney Anatomy 0.000 description 3
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
101100323865 Xenopus laevis arg1 gene Proteins 0.000 description 2
125000003277 amino group Chemical group 0.000 description 2
230000004071 biological effect Effects 0.000 description 2
210000004899 c-terminal region Anatomy 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
238000000354 decomposition reaction Methods 0.000 description 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
125000004185 ester group Chemical group 0.000 description 2
238000002523 gelfiltration Methods 0.000 description 2
125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
238000001802 infusion Methods 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
229930182817 methionine Natural products 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
238000010647 peptide synthesis reaction Methods 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000010998 test method Methods 0.000 description 2
CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 2
230000002747 voluntary effect Effects 0.000 description 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 description 1
JWUBBDSIWDLEOM-DCHLRESJSA-N 25-Hydroxyvitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C/C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DCHLRESJSA-N 0.000 description 1
JWUBBDSIWDLEOM-NQZHSCJISA-N 25-hydroxy-3 epi cholecalciferol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@H](O)CCC1=C JWUBBDSIWDLEOM-NQZHSCJISA-N 0.000 description 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
244000186140 Asperula odorata Species 0.000 description 1
235000017166 Bambusa arundinacea Nutrition 0.000 description 1
235000017491 Bambusa tulda Nutrition 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
235000008526 Galium odoratum Nutrition 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
101001135770 Homo sapiens Parathyroid hormone Proteins 0.000 description 1
101001135995 Homo sapiens Probable peptidyl-tRNA hydrolase Proteins 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
102000008109 Mixed Function Oxygenases Human genes 0.000 description 1
108010074633 Mixed Function Oxygenases Proteins 0.000 description 1
244000082204 Phyllostachys viridis Species 0.000 description 1
235000015334 Phyllostachys viridis Nutrition 0.000 description 1
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
229930003316 Vitamin D Natural products 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
235000011054 acetic acid Nutrition 0.000 description 1
150000008065 acid anhydrides Chemical class 0.000 description 1
238000005903 acid hydrolysis reaction Methods 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
150000001540 azides Chemical class 0.000 description 1
239000011425 bamboo Substances 0.000 description 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
SAKUKAQFBMDKGX-UHFFFAOYSA-N butan-1-ol;2-pyridin-2-ylacetic acid;hydrate Chemical compound O.CCCCO.OC(=O)CC1=CC=CC=N1 SAKUKAQFBMDKGX-UHFFFAOYSA-N 0.000 description 1
150000001718 carbodiimides Chemical class 0.000 description 1
PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
125000000068 chlorophenyl group Chemical group 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000003028 elevating effect Effects 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
239000008103 glucose Substances 0.000 description 1
102000058004 human PTH Human genes 0.000 description 1
229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
JBFYUZGYRGXSFL-UHFFFAOYSA-N imidazolide Chemical compound C1=C[N-]C=N1 JBFYUZGYRGXSFL-UHFFFAOYSA-N 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
125000004492 methyl ester group Chemical group 0.000 description 1
150000004702 methyl esters Chemical class 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000000203 mixture Substances 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
230000001151 other effect Effects 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
239000002994 raw material Substances 0.000 description 1
235000002639 sodium chloride Nutrition 0.000 description 1
239000002904 solvent Substances 0.000 description 1
235000000891 standard diet Nutrition 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000001308 synthesis method Methods 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000019166 vitamin D Nutrition 0.000 description 1
239000011710 vitamin D Substances 0.000 description 1
150000003710 vitamin D derivatives Chemical class 0.000 description 1
235000005282 vitamin D3 Nutrition 0.000 description 1
239000011647 vitamin D3 Substances 0.000 description 1
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
229940046008 vitamin d Drugs 0.000 description 1
229940021056 vitamin d3 Drugs 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Landscapes

Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

JP58075607A 1983-04-28 1983-04-28 〔Ｍｅｔ（Ｏ）↑８’↑１↑８〕ｈＰＴＨ−（１−３４）ペプチド Granted JPS59204159A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP58075607A JPS59204159A (ja)	1983-04-28	1983-04-28	〔Ｍｅｔ（Ｏ）↑８’↑１↑８〕ｈＰＴＨ−（１−３４）ペプチド

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP58075607A JPS59204159A (ja)	1983-04-28	1983-04-28	〔Ｍｅｔ（Ｏ）↑８’↑１↑８〕ｈＰＴＨ−（１−３４）ペプチド

Publications (2)

Publication Number	Publication Date
JPS59204159A true JPS59204159A (ja)	1984-11-19
JPH0314320B2 JPH0314320B2 (da)	1991-02-26

Family

ID=13581062

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP58075607A Granted JPS59204159A (ja)	1983-04-28	1983-04-28	〔Ｍｅｔ（Ｏ）↑８’↑１↑８〕ｈＰＴＨ−（１−３４）ペプチド

Country Status (1)

Country	Link
JP (1)	JPS59204159A (da)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5001223A (en) *	1987-05-26	1991-03-19	Merck & Co., Inc.	Parathyroid hormone antagonists with enhanced metabolic properties
US6537965B1 (en) *	1998-11-25	2003-03-25	The General Hospital Corporation	Amino-terminal modified parathyroid hormone (PTH) analogs
US9057727B2 (en)	2007-08-01	2015-06-16	The General Hospital Corporation	Screening methods using G-protein coupled receptors and related compositions
US9492508B2 (en)	2010-05-13	2016-11-15	The General Hospital Corporation	Parathyroid hormone analogs and uses thereof

1983
- 1983-04-28 JP JP58075607A patent/JPS59204159A/ja active Granted

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5001223A (en) *	1987-05-26	1991-03-19	Merck & Co., Inc.	Parathyroid hormone antagonists with enhanced metabolic properties
US6537965B1 (en) *	1998-11-25	2003-03-25	The General Hospital Corporation	Amino-terminal modified parathyroid hormone (PTH) analogs
US9057727B2 (en)	2007-08-01	2015-06-16	The General Hospital Corporation	Screening methods using G-protein coupled receptors and related compositions
US9492508B2 (en)	2010-05-13	2016-11-15	The General Hospital Corporation	Parathyroid hormone analogs and uses thereof

Also Published As

Publication number	Publication date
JPH0314320B2 (da)	1991-02-26

Publication	Publication Date	Title
IE841890L (en)	1985-01-22	Treatment of diabetes mellitus
EP0132770B1 (de)	1987-09-16	Neue Insulin-Derivate, Verfahren zu deren Herstellung und deren Verwendung sowie pharmazeutische Mittel zur Behandlung des Diabetes mellitus
JP2828250B2 (ja)	1998-11-25	真性糖尿病の治療
JP3304442B2 (ja)	2002-07-22	トリ−アルギニンインスリン
JPH04504858A (ja)	1992-08-27	肝臓特異性インシュリン類似体
CA1246478A (en)	1988-12-13	Process for the preparation of insulin derivatives, the b chain of which is lengthened c-terminally, novel insulin derivatives modified by bases, agents containing these derivatives and their use
JPS60136596A (ja)	1985-07-20	ペプチド及びこれを有効成分とする利尿剤
DE3782010T2 (de)	1993-02-18	Vom calcitonin-gen abgeleitete peptidderivate.
DE3780000T2 (de)	1993-02-04	Peptidverbindungen.
DE3587226T2 (de)	1993-08-05	Antidiabetikaverbindungen.
US4657891A (en)	1987-04-14	Diuretic peptide, and production and use thereof
JPS63198698A (ja)	1988-08-17	新規ペプチド、その製法およびそれを含有する医薬組成物
DE69030293T2 (de)	1997-07-10	Neue Peptide, deren Intermediate, Verfahren zu deren Herstellung, antiallergische Agenzien, Vasodilatoren und Immunoregulatoren
JPH0314320B2 (da)	1991-02-26
US5466666A (en)	1995-11-14	Amorphous monospheric forms of insulin derivatives
EP4421087A1 (en)	2024-08-28	Staple-containing polypeptides and application thereof
JPH0459795A (ja)	1992-02-26	カルシトニン様活性を有するポリペプチド誘導体及びその用途
JPH02262596A (ja)	1990-10-25	スルホ化カルシトニン誘導体及びその製造方法
EP4702986A1 (en)	2026-03-04	Polypeptide and use thereof
JPS6193126A (ja)	1986-05-12	成長ホルモン放出因子活性を有する医薬
JPH03220131A (ja)	1991-09-27	カソキシンｃを有効成分とする血圧降下剤
JPH03218395A (ja)	1991-09-25	モチリン様活性を有するポリペプチド及びその用途
JPH10152445A (ja)	1998-06-09	Ｃｎｐ類似体ペプチド含有製剤
JP2006516536A5 (da)	2006-11-30
DE2900926A1 (de)	1979-07-19	Therapeutisch wirksame pseudopeptide, diese enthaltende zusammensetzungen und verfahren zu deren herstellung

JPS59204159A - 〔Ｍｅｔ（Ｏ）↑８’↑１↑８〕ｈＰＴＨ−（１−３４）ペプチド - Google Patents

Info

Links

Landscapes

Priority Applications (1)

Applications Claiming Priority (1)

Publications (2)

Family

ID=13581062

Family Applications (1)

Country Status (1)

Cited By (4)

Cited By (4)

Also Published As

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