JPS59205372A - 縮合７員環化合物およびそれを含有してなる高血圧症予防・治療剤 - Google Patents

縮合７員環化合物およびそれを含有してなる高血圧症予防・治療剤

Info

Publication number
JPS59205372A
JPS59205372A JP59079996A JP7999684A JPS59205372A JP S59205372 A JPS59205372 A JP S59205372A JP 59079996 A JP59079996 A JP 59079996A JP 7999684 A JP7999684 A JP 7999684A JP S59205372 A JPS59205372 A JP S59205372A
Authority
JP
Japan
Prior art keywords
amino
oxo
benzothiazepine
acetic acid
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP59079996A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0564144B2 (cs
Inventor
Hirosada Sugihara
杉原　弘貞
Kohei Nishikawa
浩平 西川
Katsumi Ito
克己 伊藤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of JPS59205372A publication Critical patent/JPS59205372A/ja
Publication of JPH0564144B2 publication Critical patent/JPH0564144B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP59079996A 1983-04-22 1984-04-19 縮合７員環化合物およびそれを含有してなる高血圧症予防・治療剤 Granted JPS59205372A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/JP1983/000127 WO1984004306A1 (fr) 1983-04-22 1983-04-22 C0mposes cycliques a 7 membres fusionnes et leur procede de preparation
WO83/00127 1983-04-22
WO83/00342 1983-10-13
WO84/00119 1984-03-22

Publications (2)

Publication Number Publication Date
JPS59205372A true JPS59205372A (ja) 1984-11-20
JPH0564144B2 JPH0564144B2 (cs) 1993-09-14

Family

ID=13789981

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59079996A Granted JPS59205372A (ja) 1983-04-22 1984-04-19 縮合７員環化合物およびそれを含有してなる高血圧症予防・治療剤

Country Status (6)

Country Link
JP (1) JPS59205372A (cs)
AR (1) AR244217A1 (cs)
DK (1) DK196884A (cs)
SU (1) SU1526583A3 (cs)
WO (1) WO1984004306A1 (cs)
ZA (1) ZA842926B (cs)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608283A (ja) * 1983-06-29 1985-01-17 Mitsui Toatsu Chem Inc ベンゾチアゼピン誘導体およびその製造方法
JPS60174775A (ja) * 1984-02-21 1985-09-09 Mitsui Toatsu Chem Inc ベンゾチアゼピン誘導体
JPS60239475A (ja) * 1984-05-15 1985-11-28 Mitsui Toatsu Chem Inc 置換ベンゾチアゼピン誘導体
JPS61148171A (ja) * 1984-12-21 1986-07-05 Mitsui Toatsu Chem Inc ベンゾチアゼピン誘導体
WO1998035941A1 (en) * 1997-02-18 1998-08-20 Shionogi & Co., Ltd. New benzolactam derivatives and medicinal compositions containing the same
WO1998041510A1 (en) * 1997-03-14 1998-09-24 Shionogi & Co., Ltd. Novel benzolactam derivatives and medicinal compositions comprising the same

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59167577A (ja) * 1983-02-28 1984-09-21 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド チアジンおよびチアゼピン環含有化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59167577A (ja) * 1983-02-28 1984-09-21 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド チアジンおよびチアゼピン環含有化合物

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608283A (ja) * 1983-06-29 1985-01-17 Mitsui Toatsu Chem Inc ベンゾチアゼピン誘導体およびその製造方法
JPS60174775A (ja) * 1984-02-21 1985-09-09 Mitsui Toatsu Chem Inc ベンゾチアゼピン誘導体
JPS60239475A (ja) * 1984-05-15 1985-11-28 Mitsui Toatsu Chem Inc 置換ベンゾチアゼピン誘導体
JPS61148171A (ja) * 1984-12-21 1986-07-05 Mitsui Toatsu Chem Inc ベンゾチアゼピン誘導体
WO1998035941A1 (en) * 1997-02-18 1998-08-20 Shionogi & Co., Ltd. New benzolactam derivatives and medicinal compositions containing the same
WO1998041510A1 (en) * 1997-03-14 1998-09-24 Shionogi & Co., Ltd. Novel benzolactam derivatives and medicinal compositions comprising the same

Also Published As

Publication number Publication date
SU1526583A3 (ru) 1989-11-30
DK196884D0 (da) 1984-04-17
AR244217A1 (es) 1993-10-29
JPH0564144B2 (cs) 1993-09-14
DK196884A (da) 1984-10-23
ZA842926B (en) 1984-12-24
WO1984004306A1 (fr) 1984-11-08

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