JPS59500130A - 低酸素性腫瘍細胞用ニトロイミダゾ−ル放射線増感剤およびその組成物 - Google Patents

低酸素性腫瘍細胞用ニトロイミダゾ−ル放射線増感剤およびその組成物

Info

Publication number
JPS59500130A
JPS59500130A JP83500881A JP50088183A JPS59500130A JP S59500130 A JPS59500130 A JP S59500130A JP 83500881 A JP83500881 A JP 83500881A JP 50088183 A JP50088183 A JP 50088183A JP S59500130 A JPS59500130 A JP S59500130A
Authority
JP
Japan
Prior art keywords
nitroimidazole
formula
compound
hydrogen
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP83500881A
Other languages
English (en)
Japanese (ja)
Inventor
アグラワル・クリシユナ・シ−
サカグチ・マサカズ
Original Assignee
リサ−チ・コ−ポレイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by リサ−チ・コ−ポレイション filed Critical リサ−チ・コ−ポレイション
Publication of JPS59500130A publication Critical patent/JPS59500130A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP83500881A 1982-02-08 1983-02-07 低酸素性腫瘍細胞用ニトロイミダゾ−ル放射線増感剤およびその組成物 Pending JPS59500130A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/346,914 US4462992A (en) 1982-02-08 1982-02-08 Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
US346914FREGB 1982-02-08
PCT/US1983/000165 WO1983002774A1 (en) 1982-02-08 1983-02-07 Nitroimidazole radiosensitizers and composition thereof

Publications (1)

Publication Number Publication Date
JPS59500130A true JPS59500130A (ja) 1984-01-26

Family

ID=23361561

Family Applications (1)

Application Number Title Priority Date Filing Date
JP83500881A Pending JPS59500130A (ja) 1982-02-08 1983-02-07 低酸素性腫瘍細胞用ニトロイミダゾ−ル放射線増感剤およびその組成物

Country Status (10)

Country Link
US (1) US4462992A (2)
EP (1) EP0100363B1 (2)
JP (1) JPS59500130A (2)
CA (1) CA1197854A (2)
DE (1) DE3371337D1 (2)
DK (1) DK422083A (2)
GR (1) GR78100B (2)
IE (1) IE830233L (2)
IT (1) IT1163086B (2)
WO (1) WO1983002774A1 (2)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03223258A (ja) * 1990-01-26 1991-10-02 Pola Chem Ind Inc ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3682723D1 (de) * 1985-08-15 1992-01-16 Asahi Denka Kogyo Kk Strahlungssensibilisator.
US4758669A (en) * 1986-05-05 1988-07-19 Radiation Oncology Center Research And Development Corporation 4-(nitrone aryl) dihydropyridines
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
GB8728418D0 (en) * 1987-12-04 1988-01-13 Jenkins T C Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment
IT1226100B (it) * 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
US5036096A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives
US5036089A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company 2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents
US4954515A (en) * 1988-11-25 1990-09-04 Warner-Lambert Company Haloalkylaminomethyl-2-nitro-1H-imidazoles
CA1339130C (en) * 1989-08-18 1997-07-29 Leonard Irving Wiebe Markers of tissue hypoxia
US5808091A (en) 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
WO1994014778A1 (fr) * 1992-12-18 1994-07-07 Pola Chemical Industries, Inc. Derive optiquement actif de 2-nitroimidazole, son procede de production, et intermediaire pour sa production
US5486360A (en) * 1993-04-22 1996-01-23 St. Joseph Health Centre Method of treating tumour cells using catalase
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
WO1995009844A1 (en) * 1993-10-04 1995-04-13 Board Of Regents, The University Of Texas System Rapid synthesis and use of 18f-fluoromisonidazole and analogs
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US20090117199A1 (en) * 1998-08-06 2009-05-07 Scott Timothy C Method of treatment of cancer
US8557298B2 (en) * 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US8470296B2 (en) * 1998-12-21 2013-06-25 Provectus Pharmatech, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en) 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
US20030216758A1 (en) * 2001-12-28 2003-11-20 Angiotech Pharmaceuticals, Inc. Coated surgical patches
EP2181704B1 (en) 2002-12-30 2015-05-06 Angiotech International Ag Drug delivery from rapid gelling polymer composition
JP5297815B2 (ja) 2007-01-26 2013-09-25 株式会社ポーラファルマ 医薬組成物
US8703188B1 (en) 2012-11-19 2014-04-22 Azanta A/S Dispersible tablet

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646057A (en) * 1969-04-06 1972-02-29 Hoffmann La Roche 2-nitroimidazoles
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
US4282232A (en) * 1979-04-26 1981-08-04 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
US4371540A (en) * 1979-09-14 1983-02-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03223258A (ja) * 1990-01-26 1991-10-02 Pola Chem Ind Inc ２―ニトロイミダゾール誘導体、その製造法及びこれを有効成分とする放射線増感剤

Also Published As

Publication number Publication date
EP0100363A1 (en) 1984-02-15
US4462992A (en) 1984-07-31
IE830233L (en) 1983-08-08
DK422083D0 (da) 1983-09-16
EP0100363B1 (en) 1987-05-06
EP0100363A4 (en) 1984-06-13
WO1983002774A1 (en) 1983-08-18
IT8319481A0 (it) 1983-02-08
IT1163086B (it) 1987-04-08
DK422083A (da) 1983-09-16
CA1197854A (en) 1985-12-10
DE3371337D1 (en) 1987-06-11
GR78100B (2) 1984-09-26

Similar Documents

Publication Publication Date Title
JPS59500130A (ja) 低酸素性腫瘍細胞用ニトロイミダゾ−ル放射線増感剤およびその組成物
KR102823105B1 (ko) Erk 억제제로서 작용하는 스피로 화합물 및 이의 응용
US4282232A (en) Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
US10202400B2 (en) Cortistatin analogues and syntheses thereof
JP5385923B2 (ja) Ｎ−複素環式カルベン白金誘導体、この調製、およびこの治療用途
JPH01110675A (ja) ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
US4631289A (en) Useful in radiotherapy of chemotherapy 4-aziridino-1-nitroimidazol-1-yl-2,3-butanediols
WO1991011440A1 (en) 2-nitroimidazole derivative, production thereof, and radiosensitizer containing the same as active ingredient
US20140058106A1 (en) System for fluorinating organic compounds
CN116194449A (zh) 一种内皮素a(eta)受体拮抗剂化合物及其制备方法和医药用途
US8686158B2 (en) High-valent palladium fluoride complexes and uses thereof
CA2231837A1 (en) Radiosensitizing taxanes and their pharmaceutical preparations
JPH0515705B2 (2)
CA2832439C (en) Migrastatins and uses thereof
JP2848602B2 (ja) 新規含フッ素２−ニトロイミダゾールおよびそれを含む放射線増感剤
EP3805225A1 (en) SELECTIVE A2a RECEPTOR ANTAGONIST
JPS62919B2 (2)
CN113087743A (zh) 四氢大麻酚衍生物及其制备方法和在医药上的应用
JPS6322069A (ja) 複素多環式芳香族化合物
JPS63170314A (ja) イミダゾールー及びトリアゾール誘導体を含有する抗菌剤
US4463006A (en) Diglycidyl-pteridine compounds
US4443458A (en) Aminocrotonyl 3,5-dinitropyridine useful as adjuncts to radiation therapy
JPS63170375A (ja) ヘテロ環化合物誘導体、その製造法およびこれを有効成分とする放射線増感剤
JP4328875B2 (ja) アルキル−８−ニトロキサンチン誘導体
JPH06279415A (ja) 低酸素性細胞放射線増感剤