JPS595107A - Keratolytic - Google Patents

Abstract

PURPOSE:Keratolytics containing an anionic surfactant and another surfactant having N atoms in the molecule in combination, capable of cleaning the skin without damaging the skin, and removing the keratin with ease. CONSTITUTION:Keratolytics containing one or two or more anionic surfactants, e.g. sodium lauryl sulfate, and one or two or more other surfactants having nitrogen atoms in the molecule other than the anionic surfactants, e.g. lauryldemethylamine oxide, at preferably (20:1)-(1:20), preferably (10:1)-(1:10), molar ratio. The keratolytics have improved dissolving action on the keratinized tissee and a slight irritation to the skin. Therefore, the agent is used directly or incorporated with various bases, e.g. a liquid, jelly, ointment or creamy base, for use.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a keratolytic agent that can cleanse the skin and easily remove dead skin cells without damaging the skin.

Traditionally, products aimed at exfoliating various parts of the body include pumice stone using physical polishing, monosalicylic acid, urea, and lactic acid.
There are emulsions, ointments, etc. that utilize chemical dissolving action represented by enzymes.

However, these methods are not completely satisfactory because they are painful, damage the skin, and are insufficiently removed.

In view of these circumstances, the present inventors have extensively searched for substances that have excellent effects as keratolytic agents in order to solve the above-mentioned drawbacks, and have surprisingly discovered that surfactants with a certain structure have been found. When used in combination, it is far more effective than the salicylic acid gel commonly used by dermatologists or the conventionally known keratolytic agents such as salicylic acid, urea, lactic acid, and enzymes, and is less irritating to the skin. The present inventors have discovered that the number of cases is extremely low, and have completed the present invention. That is, the present invention is comprised of one or more anionic surfactants and one or more surfactants other than anionic surfactants that have a nitrogen atom in the molecule. The composition of the present invention will be described in detail below.

The anionic surfactant used in the present invention is an anionic surfactant that has one or more types of carboxylic acid group, sulfonic acid group, sulfuric acid ester group, or phosphoric acid ester group in the molecule, and has a carboxylic acid group. Examples include fatty acids, ether carboxylic acids and their salts, carboxylates such as condensates of amino acids and fatty acids, and examples of sulfonates include alkyl sulfonates, sulfosuccinates, and esters. Sulfonates, alkylaryl and alkylnaphthalene sulfonates, N-7 silsulfonates, formalin condensed sulfonates, etc., those having sulfate ester groups include sulfated oils, ester sulfates, alkyl sulfates, Ether sulfates, alkyl allyl ether sulfates, amide sulfates, etc. Examples of those having a phosphoric acid ester group include alkyl phosphates 1, ether phosphates, alkyl allyl ether phosphates, amide phosphates, etc. be able to. One or more types are arbitrarily selected from these.

The surfactants having a nitrogen atom in the molecule used in the present invention include amphoteric surfactants, semipolar surfactants, nonionic surfactants, and cationic surfactants having a nitrogen atom in the molecule. Examples of amphoteric surfactants include carboxybetaine, sulfobetaine 1-aminocarboxylate, imidacillin derivatives, etc. Semipolar surfactants include amine oxides, etc. Nonionic surfactants include fatty acid alkanolamides, polyamides, etc. Oxyethylene fatty acid amide-alkanolamine esters, polyoxyethylene alkylamine, etc. are used as cationic surfactants such as fatty acid amine salts, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridinium salts, imidazolium salts, etc. can be mentioned. One or more of these may be arbitrarily selected.

The mixing ratio of the anionic surfactant and the surfactant having a nitrogen atom in the molecule and less than or equal to the anionic surfactant is preferably 20:1 or 1:a), more preferably 1:1 or 1:a). The keratolytic work according to the present invention has excellent keratolytic work and is less irritating to the skin, so it can be used as is or in various forms such as liquid, jelly, ointment, and cream. It can be blended into a base and used for a wide range of purposes.

(The following is a blank space) Next, the present invention will be explained in detail using examples. Prior to that, the evaluation method adopted in each example will be explained.

The stratum corneum for evaluating keratolysis was collected from guinea pigs. The method involves removing hair from a guinea pig using clippers or a depilatory agent, and after the erythema has subsided, the entire skin layer is separated using scissors. After peeling, subcutaneous fat is excised with scissors, then immersed in warm water at 0°C for 1 minute, cooled on ice, and the epidermis is peeled cleanly with a bottle set. The epidermis was soaked at 37"C with 01% trypsin solution (buffer pH 7,8).
Treat for 30 minutes to digest living cells and obtain the stratum corneum. The stratum corneum was washed with water, dried, and used for testing. The stratum corneum was cut into squares, immersed in 15 cc of each solution, and kept in a 25"C thermostatic chamber over time to check the condition of the stratum corneum. Observation and evaluation of keratolytic properties.

The evaluation results are expressed using the following symbols. Comparative Example 1> The stratum corneum (hereinafter referred to as the margin) was added to salicylic acid gel, which is commonly used by dermatologists, or a conventionally known keratolytic solution. Comparative Example 2> Surfactant Observation results when the stratum corneum is immersed in a solution of the agent alone.

The surfactants used are shown below.

(Anionic surfactant) Sodium laurate polyoxyethylene (3) Sodium lauryl ether carboxylate Sodium N-lauryl sarcosinate y-Lauryl Sodium N-methyl-β-alanine N-Lauryl daltamate lauryl Sodium sulfonate Sodium lauryl benzene sulfonate Sodium lauryl thionate α-olefin sulfonate α-sulfonated sodium laurate
Methyl-N-Lauryl Taurine Sodium Lauryl Sulfate Disodium Laurate Ethanolamide Sulfosuccinate Sodium Lauryl Sulfoacetate Gelioxyethylene (3) Lauryl Ether Sulfate Monolauryl Sodium Phosphate Polyoxyethylene (3) Sodium Lauryl Ether Phosphate Sodium lauryl monoglysal 7ate (amphoteric surfactant) N,N-di)lfA-11-Ura+)k-N-kaA4Yaso, Ah, 3, 5 Kates (Lauryl betaine) N,N -dimethyl-N-lau, lylu N-sulfomethylammonium betaine 2-lauryl-1-hydroxyethyl-1-carboxymethylimitaine linium betaine (semipolar surfactant) lauryl dimethyl Amine oxide (cationic blush active agent) lauryl trimethyl ammonium chloride lauryl pyridinium chloride (nonionic face active agent) polyoxyethylene a9 lauryl ether polyoxyethylene α9 lauric acid ester lauric acid jetanolamide polyoxyethylene lauryl amine polyoxy Ethylene A9 Lauryl Phenyl Ether All surfactants at 1100rn, lomM, 1mM
The condition was observed after adjusting the condition to Results of changes in the condition of the horny layer over time.

Comparative Example 3> Effects on stratum corneum when changing the blending ratio and concentration of sodium lauryl sulfate (sr, s) and polyoxyethylene αS lauryl ether (aU(Σ0)ts), a surfactant that does not contain nitrogen atoms. State change result.

Note that even when the total concentration was changed to 10 mM% lmM, the state of the stratum corneum did not change.

(Below, blank space below) <Example 3><Example5> Patent applicant Shiseido Co., Ltd. Proceedings correction form (method) % formula % 1. Indication of the case Patent Application No. 114688 of 1982 2 Name of the invention Keratolytic agent 3. Person making the amendment: September 9, 1980 (shipment date 98 days of the same year) 5. Specification subject to amendment 6. Contents of amendment

Claims (1)

[Scope of Claims] A keratin characterized by comprising one or more anionic surfactants and one or more surfactants other than anionic surfactants that have a nitrogen atom in the molecule. solubilizer. (Margin below)