JPH0249714A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic sufficiently exhibiting effects of medicinal components, excellent safety and feeling in use containing a compound surfactant, beautifying agent, dandruff inhibitor and antiseborrheic. CONSTITUTION:One or more of anionic surfactants, one or more of surfactants containing nitrogen in the molecule except the anionic surfactants in the molar ratio of (20:1)-(1:20) and further one or more selected from the group consisting of a beautifying agent, a dandruff inhibitor and antiseborrheic are used, blended with conventional components and prepared by a conventional procedure to give the aimed substance. The total amounts of the surfactants blended in the cosmetic are 0.01-5wt.% and the amounts of the medicinal components blended are 0.01-5wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field 1] The present invention provides cosmetics 1'1 that fully exhibits the effects of drugs.
Regarding. Kawani Familiar i: Text, one or more types of anionic surfactants, one or more types of surfactants other than anionic surfactants that have a nitrogen atom in the molecule, and skin whitening. The present invention relates to cosmetics 11 characterized in that it contains one or more selected from the group consisting of anti-dandruff agents, anti-dandruff agents, and anti-seborrheic agents.

[Prior art 1] The surface of the skin is called the stratum corneum, and it originally has a physiological function as a barrier to prevent foreign substances from entering the body. Merely blending the medicinal ingredients into a base will not produce sufficient drug effects.

[Problem to be Solved by the Invention 1] In view of the above-mentioned problems, the present inventors have conducted intensive research to develop cosmetics that fully exhibit the effects of medicinal ingredients.
The present invention has now been completed.

[Means for Solving the Problems 1] That is, the present invention uses one or more anionic surfactants and one or more surfactants other than the anionic surfactants that have a nitrogen atom in the molecule. , and one or more selected from the group consisting of a whitening agent, an anti-dandruff agent, and an anti-seborrheic agent.

Hereinafter, the configuration of the present invention will be explained in detail.

The anionic surfactant used in the present invention may be any one having one or more types of carboxylic acid group, sulfonic acid group, sulfuric acid ester group, or phosphoric acid ester group in the molecule. Those containing fatty acid soaps, ether carboxylic acids and their salts, carboxylic acid salts such as condensates of amino acids and fatty acids, etc., and those containing sulfonates include alkyl sulfonates,
Examples of sulfosuccinic acid, ester sulfonates, alkylaryl and alkylnaphthalene sulfonates, N-acylsulfonates, formalin condensation sulfonates, etc. having sulfate ester groups include sulfated oils and ester sulfates. , alkyl sulfates, ether sulfates, alkyl allyl ether sulfates, amide sulfates, etc., and those having a phosphoric acid ester group include alkyl phosphates, amide phosphates, ether phosphates, alkyl allyl ether phosphates, etc. Examples include salt. One or more types are arbitrarily selected from these.

Examples of surfactants having a nitrogen atom in the molecule other than the anionic surfactant used in the present invention include amphoteric surfactants having a nitrogen atom in the molecule, semipolar surfactants, nonionic surfactants, Examples include cationic surfactants. Amphoteric surfactants include carboxybetaine, sulfobetaine, aminocarboxylic acid salts, imidacillin derivatives, etc., semipolar surfactants include amine oxides, and nonionic surfactants include fatty acid alkanolamides, polyamides, etc. oxyethylene fatty acid amide,
Examples of cationic surfactants include alkanolamine esters, polyoxyethylene alkylamine, etc., and fatty acid amine salts, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridium salts, imidazolium salts, etc. . One or more of these may be arbitrarily selected and used.

The blending ratio of the anionic surfactant used in the present invention and a surfactant other than the anionic surfactant that has a nitrogen atom in its molecule is preferably 20:1 to 1:20 in terms of molecular ratio. The ratio is preferably 10:1 to 1:10.

As the whitening agent used in the present invention, ascorbic acid,
Examples include ascorbyl civalmitate, ascorbic acid 2-sulfuric acid, saxifrage extract, placenta extract, kojic acid, and the like.

Anti-dandruff agents used in the present invention include zinc pyrithione, trichlorocarbanilide, piroctone olamine, and the like.

Examples of the antiseborrheic agent used in the present invention include sulfur, peony, botanical, pyridoxine hydrochloride, pyridoxine tripalmitate, Hypericum perforatum, and the like.

When the whitening agent, anti-dandruff agent, and anti-seborrheic agent used in the present invention are mixed with the surfactant of the present invention and applied to the skin, the effects of the agents are fully exhibited. Both medicinal ingredients intended for local action and medicinal ingredients intended for systemic action exhibit excellent effects.

The amount of the whitening agent, anti-dandruff agent, and anti-seborrheic agent used in the present invention may be sufficient as long as it has the desired medicinal effect, and it depends on the type of medicinal ingredient, the skin type and symptoms of the user, etc. Although it cannot be said generally, the amount of the present surfactant is approximately 0.001 to 50% by weight per 1% by weight of the medicinal ingredient.

The above-mentioned surfactants may be used as they are after appropriately mixing the medicinal ingredients, but taking into consideration the feel of use and the ease of application, for boat fishing, the constituent ingredients may be added to a suitable cosmetic, such as a cream. It is used by mixing it into the base of gel, lotion, milky lotion, etc.

In that case, the blending amount of each component is the same (although it varies depending on the type of medicinal ingredient, etc., the following range is generally the preferred blending amount range. Namely, anionic surfactant and anionic surfactant) The total blending amount of surfactants other than surfactants having nitrogen atoms in their molecules is 0.001 to 10% in cosmetics.
It is preferably 0.01 to 5% by weight, and the medicinal component is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight. Also,
The ratio of the anionic surfactant to the surfactant other than the anionic surfactant that has a nitrogen atom in its molecule is the ratio described above, that is, the molecular ratio is 20 = 1 to 1:201, preferably 10:1 to 1. :10 ratio is applied as is.

In addition to the above-mentioned essential components, the cosmetics according to the present invention may contain other components that are generally included in cosmetics. These ingredients include scutellariae extract, scutellariae extract, scutellariae extract, ivy extract, yarrow extract, japonica extract, birch extract, horse chestnut extract, loquat extract, glycyrrhizinic acid, β-glycyrrhetinic acid, and glycyrrhizin. Anti-inflammatory agents such as monoammonium acid, stearyl glycyrrhetinate, hinokitiol, D-camphor, L-menthol, oxidized nails), calamine, allantoi ν, diphenhydramine hydrochloride, carrot extract, mallow extract, garlic extract, iris extract , Yokuinin extract, Grape extract, Luffa extract, Peach extract, Yeast extract, Royal Billy, Sodium Copper U fillin, γ-oryzanol, Hinokitiol, β-carotene, urea, allantoin, carrageenan, ethinyl estradiol, L-alanine, DL-
Serine, disodium adenosine triphosphate, pasitotenyl ethyl ether, biotin, inosit, ergocalciferol, activators such as nicotinamide, black snail, 7-oryzanol, DL-camphor, dextran sodium sulfate, riluic acid DL-α - Blood circulation promoters such as tocopherol and DL-α-tocopherol acetate, keratin softeners such as resorcin and lactic acid, horsetail extract,
Astringents such as mulberry, commonweed, dead manflower extract, horse chestnut extract, grape wreath extract, mugwort extract, zinc oxide, calamine, aloe extract, lily extract, quince seed, xanthan gum, sodium dextran sulfate, sodium chondroitin sulfate. , moisturizing agents such as carrageenan, sodium hyaluronate, urocanic acid, olive oil, royal jelly oyster extract, yeast extract, ascorbic acid, nutritional supplements such as Inojito, avocado oil, safflower oil, tea seed oil, jojoba oil, ononis. Extracts, urea, linoleic acid, cholesterol, dehydrocholesterol, dihydrocholesterol, lanosterol, softeners such as glydyretinyl stearate, polyhydric albinol, oil, wax, acids, alkalis, other surfactants, powders, pigments , dyes, preservatives, antioxidants, ultraviolet absorbers, chelating agents, water-soluble polymers, montmorillonite, alcohols, solvents, perfumes, etc.

[Examples] Next, the present invention will be specifically explained with reference to Examples, but the present invention is not limited only to these Examples. The blending amount is in weight%.

Example 1 Cream (1) Ascorbic acid 2-sulfuric acid (2) Pyrene glycol (3) Glycerin (4) Liquid paraffin (5) Adipic acid 1 pill (6)
Sodium dodecyl sulfate (7) Dodecyldimethylamine oxide→noid (8) Glycerin monofatty acid ester 1.0 8.0 5.0 1.0 3.0 0, O8 0.16 1.5 (9) Preservative Appropriate amount (10)
Clay mineral (bentonite) 6.0 (11) Purified water Residue comparative example 1 Cream (1) Ascorbic acid 2-sulfuric acid (2) Pyrene glycol (3) Glycerin (4) Liquid paraffin (5) Diisopropyl adipate ( (S)
Glycerin monofatty acid ester (7) Preservative (8) Clay mineral (bentonite) (9) Purified water 1.0 8.0 5.0 1.0 3.0 1.5 Appropriate amount 6.0 Remaining Example 1 and comparison The whitening effect of the cream prepared in Example 1 was compared. The test method and evaluation method are shown below.

That is, the creams prepared in Example 1 and Comparative Example 1 were continuously applied to the faces of 20 female melasma patients for 4 weeks, and evaluations were made before and after that.

Judgment criteria are: "Remarkable improvement effect on melasma" (Score 2) "Obvious improvement effect" (Score 1) "Slight improvement effect on mold" (Score 0.5) "No change"
(Score O) An average score was determined for each base.

Table 1 As is clear from Table 1, it can be seen that the cream of Example 1 has excellent whitening effect.

Example 2 Cream (1) Kojic acid (2) Dehydrocholesterol 2.0 0.5 Tea seed oil Glycerin Monofatty acid ester Sodium dodecyl sulfate Sodium dodecyl phosphate Sodium lauryl isothionate Dodecyl dimethylamine oxide lauric acid Jetanolamide Liquid paraffin Setanol Preservative Clay mineral (bentonite) Fragrance Ion exchange water 0.2 1.4 0.5 0.6 0.2 1.14 0.2 4.0 1.0 Appropriate amount 5.0 Appropriate amount remaining Comparative Example 3 Cream (1) Kojic acid 2.0 Dehydrocholesterol Teaseed oil Glycerin Monofatty acid ester Liquid paraffin Cethanol Preservative Clay mineral (bentonite) Fragrance 1 Ion exchange water 0.5 0.2 1.4 4.0 1 .0 Appropriate amount 5.0 Appropriate amount Remaining Example 2 and Comparative Example 2 were tested for whitening effect in the same manner. The results are shown in Table-2.

Table 2: It can be seen that it has excellent whitening effect. It also showed excellent effects on skin flexibility.

Example 3 Hair Tonic 1 Piroctone Olamine 1.02 DL-α-Tocopherol Acetate 0.33 Lily Extract
0.054) Piridoxine hydrochloride 0.075 Hinokitiru
0.036 Sothorium dodecyl sulfate
0.27 Dodecyldimethylamine oxide 0.7 (8) Polyoxyethylene (40 mol addition) hydrogenated castor oil derivative 0.5 (9) Ethyl alcohol 50.0 (
10) Sakura (li agent appropriate amount (1)
1) Fragrance Appropriate amount (12) Purified water As is clear from Residue Table 2, the cream of Example 2 has the following properties: 3 Lily extract
0,05 (pyridogycine tetrahydrochloride
0.07 (5 Hinoki Chiru
0.03 (6-boriogysyethylene (40 mol addition)) Hydrogenated castor oil derivative 0.5 (7) Ethyl alcohol 50.0 (
8) Gentle (÷i agent appropriate amount)
9) Appropriate amount of fragrance (10)
Purified water Use the remaining water and refill it at the end of the test period. The weight of Ll dandruff accumulated over 3 days after hair washing was compared with that of dandruff. Accumulated dandruff was collected by sucking the head using a suction device equipped with a filter cloth.

The reduction in dandruff caused by the use of hair tonic was calculated using the following formula.

A dandruff suppression test was conducted for Example 3 and Comparative Example 3.

The test method and evaluation method are shown below.

Twelve men between the ages of 22 and 36 with relatively heavy dandruff were selected as subjects, and each sample was tested on a total of 12 men, six men each. Before the start of the test, wash your hair with a normal shampoo, collect the accumulated dandruff for 3 days after washing, and compare the weight of the collected dandruff with the weight of the collected dandruff and the weight of each month, Example 3 and Comparative Example 3 above.
Table 3 As is clear from Table 3, the hair tonic of Example 3 has an excellent dandruff suppressing effect.

Pyridoxine hydrochloride Salicylic acid Loquat extract I--Menthol Cefnol Petrolatum P Squalane Dimethylpolysiloxane Acylmethyl taurine Na Lauryl betaine Glycerin monostearate Glycerin Dipropylene glycol Carboxy vinyl polymer OH Preservative; ↓ Ion exchange water 0.05 0 .1 0.02 0.2 1.0 2.0 4.0 2.0 0.6 0.8 2.0 5.0 4.0 0.3 0.1 Appropriate amount Appropriate amount remaining Example 4 Emulsion comparative example 4 Milk τil Pyridoxine hydrochloride salicylic acid Loquat extract L-menthol cetanol Vaseline P Squalane dimethyl borisiloxane glycerin monostearate Glycerin dipropylene glycol carboxyvinyl polymer OH Preservatives t't Ion exchange water 0.05 0.1 0 .02 0.2 1.0 2.0 4.0 2.0 2.0 5.0 4.0 0.3 0.1 ia amount iI ¥1 image residual, that is, 20 healthy women suffering from acne. The emulsions prepared in Example 4 and Comparative Example 4 were applied to the face for 4 weeks, and evaluations were made before and after.

Judgment criteria are: ``Remarkable improvement effect on acne'' (score 2) ``Obvious improvement effect'' (score 1) ``Slight improvement effect on mold'' (score 0.5) ``No change''
(Score O) An average score was determined for each base side. The results are shown in Table-4.

Table 4 The acne-improving effects of the emulsions prepared in Example 4 and Comparative Example 4 were compared. The test method and evaluation method are shown below.

As is clear from Table 4, it can be seen that the emulsion of Example 4 has an excellent acne-improving effect.

Example 5 Hair liquid trichlorocarbanilide acetic acid DL-α-tocofucconylol polyoxypropylene (40 mol addition) butyl ether ethyl alcohol acyl glutamate monosodium oleyl dimethylamine oxide fragrance ion-exchanged water 0.3 (5) lauryl dimethyl 0. 1 15.0 50.0 0.4 1.2 Appropriate amount of residual amine oxide 6) Glycerin? ) 1.3-Butylene glycol 8) Ethyl alcohol 9) Preservative 10) Buffer 11) Ion exchange water 0.6 2.0 1.0 10.0 Appropriate amount Appropriate amount Residual The lotion of Example 6 has excellent It showed a whitening effect and also showed a skin revitalizing effect.

The Hearigid of Example 5 showed excellent dandruff suppressing effects.

Example 6 Lotion (1) Ascorbic acid 2-sulfuric acid (2) Placenta extract (3) Bantothenyl ethyl ether (4) Monosodium lauroyl glutamate 0.3 0.2 0.2 0.5 [Effects of the invention] This invention The cosmetic according to the invention is a cosmetic that fully exhibits the effects of medicinal ingredients and is safe and feels good when used.

Patent applicant: Shiseido Co., Ltd.

Claims (1)

[Claims] (1) One or more anionic surfactants, one or two or more surfactants other than anionic surfactants that have a nitrogen atom in the molecule, and a whitening agent, anti-dandruff agent, and anti-grease agent. A cosmetic containing one or more selected from the group consisting of leakage agents.