JPS5953499A - デスオキシウリジン誘導体、その製造法および医薬 - Google Patents

デスオキシウリジン誘導体、その製造法および医薬

Info

Publication number
JPS5953499A
JPS5953499A JP58150111A JP15011183A JPS5953499A JP S5953499 A JPS5953499 A JP S5953499A JP 58150111 A JP58150111 A JP 58150111A JP 15011183 A JP15011183 A JP 15011183A JP S5953499 A JPS5953499 A JP S5953499A
Authority
JP
Japan
Prior art keywords
compound
acid addition
pyrimidine
formula
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP58150111A
Other languages
English (en)
Japanese (ja)
Inventor
ハ−フリ−ト・グリ−ングル
エ−リツヒ・バネツク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of JPS5953499A publication Critical patent/JPS5953499A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP58150111A 1982-08-17 1983-08-16 デスオキシウリジン誘導体、その製造法および医薬 Pending JPS5953499A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH492282 1982-08-17
CH4922/82 1982-08-17

Publications (1)

Publication Number Publication Date
JPS5953499A true JPS5953499A (ja) 1984-03-28

Family

ID=4284858

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58150111A Pending JPS5953499A (ja) 1982-08-17 1983-08-16 デスオキシウリジン誘導体、その製造法および医薬

Country Status (16)

Country Link
JP (1) JPS5953499A (fr)
AU (1) AU1800483A (fr)
BE (1) BE897516A (fr)
DE (1) DE3390162T1 (fr)
DK (1) DK372283A (fr)
ES (1) ES8604943A1 (fr)
FI (1) FI832884A7 (fr)
FR (1) FR2531962B1 (fr)
GB (1) GB2125401B (fr)
IL (1) IL69497A0 (fr)
IT (1) IT1169765B (fr)
NL (1) NL8302859A (fr)
PT (1) PT77209B (fr)
SE (1) SE8304408L (fr)
WO (1) WO1984000759A1 (fr)
ZA (1) ZA836072B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
CA1295998C (fr) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides et leur utilisation en tant qu'agents antineoplasiques
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
US5215971A (en) * 1986-12-19 1993-06-01 Medivir Ab Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5821357A (en) * 1992-06-22 1998-10-13 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
NO932286L (no) * 1992-06-22 1993-12-23 Lilly Co Eli Stereoselektiv anion-glykosyleringsprosess
US5594124A (en) * 1992-06-22 1997-01-14 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
SE9701219D0 (sv) * 1997-04-04 1997-04-04 Astra Pharma Prod New compounds
US7244717B2 (en) * 2001-08-24 2007-07-17 Koronis Pharmaceuticals, Incorporated Mutagenic nucleoside analogs for the treatment of viral disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3709874A (en) * 1970-03-19 1973-01-09 Syntex Corp 1-beta-d-arabinofuranosyl cytosine derivatives and methods of preparing
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
GB2060604B (en) * 1979-10-03 1983-11-23 Univ Birmingham And Stichting E15-(2-halogenovinyl)-2'-deoxycytidines
DE3002197A1 (de) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel
DE3010399A1 (de) * 1980-03-18 1981-09-24 Kailash Kumar Dr. 2359 Lentföhrden Gauri Verwendung von 5-haloalkyl-pyrimidin-nukleosiden als virostatika und cytostatika
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof

Also Published As

Publication number Publication date
DK372283A (da) 1984-02-18
DE3390162T1 (de) 1985-02-21
ES8604943A1 (es) 1986-02-16
NL8302859A (nl) 1984-03-16
FI832884L (fi) 1984-02-18
PT77209A (en) 1983-09-01
FR2531962A1 (fr) 1984-02-24
FI832884A0 (fi) 1983-08-10
GB2125401A (en) 1984-03-07
GB8321880D0 (en) 1983-09-14
PT77209B (en) 1986-03-18
AU1800483A (en) 1984-02-23
IT1169765B (it) 1987-06-03
WO1984000759A1 (fr) 1984-03-01
SE8304408D0 (sv) 1983-08-15
IL69497A0 (en) 1983-11-30
FI832884A7 (fi) 1984-02-18
ZA836072B (en) 1985-03-27
ES524997A0 (es) 1986-02-16
GB2125401B (en) 1985-10-16
IT8322565A0 (it) 1983-08-16
SE8304408L (sv) 1984-02-18
DK372283D0 (da) 1983-08-15
FR2531962B1 (fr) 1986-11-14
BE897516A (fr) 1984-02-13

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