JPS61210036A - Sulfur-compounded external drug for skin - Google Patents

Abstract

PURPOSE:To provide a sulfur-compounded external drug for skin, obtained by compounding insoluble polymer powder together with sulfur to an external drug, preventing the coagulation of sulfur during the production or storage of the drug, giving improved stability to the drug compounded with the agent, and useful for the prevention and remedy of pimple and the reducive bleaching of the skin. CONSTITUTION:A sulfur-containing external drug for skin having improved stability can be produced by adding polymer powder insoluble in the base of an external dermatic drug (e.g. polyethylene, polyvinyl chloride, crystalline cellulose powder, etc.) together with sulfur to the dermatic drug base. The amount of the polymer powder is preferably >=1/2 of sulfur. The external dermatic drug base to be compounded with the insoluble polymer powder in combination with sulfur is e.g. cleansing agent, remedy for pimple, skin-beautifying cosmetic, etc., and conventional generations or creamy base, etc., can be used. An external dermatic drug having extremely high quality and free from coagulation of sulfur can be produced by this process.

Description

[Detailed Description of the Invention] [Field of Industrial Application] The present invention relates to a skin external preparation that improves the stability of the combined preparation by incorporating an insoluble powder into the skin external preparation base together with sulfur. be.

[Prior Art] Sulfur has conventionally been used in ointments, creams, facial cleansers, etc. for the purpose of preventing and treating acne scarring, and has been used in many external skin preparations for the purpose of reductive bleaching.

However, sulfur aggregates in skin preparations during manufacturing or storage, making it impossible to disperse uniformly, and the aggregates accelerate sedimentation, increasing deterioration of quality.

[Problems to be solved by the invention] In view of the above-mentioned circumstances, the present inventors have conducted intensive research and found that if insoluble polymer powder is combined with sulfur in the formulation of external skin preparations, sulfur will be released not only during manufacturing but also during storage. The present invention was completed based on the discovery that the aggregation of .

[Means and actions for solving the problem] That is,
The present invention is a skin external preparation characterized by incorporating an insoluble powder into the skin external preparation base together with sulfur, thereby improving the stability of the combined preparation.

The sulfur used in the present invention may be one that is normally supplied for external use on the skin, and the amount of sulfur to be added is arbitrary and determined depending on the expected degree of effect. However, if the amount of sulfur blended is extremely large, the amount of the skin external preparation base will be reduced, and the skin external preparation base may not be able to exhibit its own performance. Preferably it is 0.1 to 10%.

In addition, in the present invention, insoluble polymer powders that can be incorporated into external skin preparations together with sulfur include polyethylene, polypropylene,
Hydrocarbon polymers such as polystyrene and polystyrene divinylbenzene copolymers, halogenated hydrocarbon polymers such as vinyl chloride, vinylidene chloride, and ethylene fluoride, polyamide polymers such as nylon, acrylonitrile, and methyl methacrylate. Powders of general-purpose synthetic polymer materials such as acrylic polymers such as phenol polymers and polyester polymers, and polymer powders derived from natural products such as crystalline cellulose powder can be used.

In any case, the effects of the present invention will not be exhibited unless the powder blended with the expectation of the effects of the present invention is insoluble in the base of the external skin preparation.

Also, as the powder to be incorporated into the oil-based skin external preparation base, most of the above-mentioned polymer powders can be used in consideration of their solubility with the skin external preparation base. In the case of coarsely oily bases, powdered sugars such as sucrose, lactose, and sugar alcohols can also be used.

One or more of the above-mentioned polymer powders are used, and the amount of the polymer powder to be blended is determined by taking into consideration the amount of sulfur that can be blended into the external skin preparation. The amount to exhibit the effects of the present invention is preferably 1/2 or more of the amount of sulfur. Furthermore, if a polymer powder that is extremely larger than the amount of sulfur is blended, the effect of the present invention will not be reduced, but as in the case of sulfur, the amount of the skin external preparation base will decrease and the skin external preparation will become whiter. This will impede the performance of the layer.

The base for external skin preparations containing sulfur and insoluble polymer powder according to the present invention includes detergents, anti-acne drugs, whitening cosmetics, etc., and is commonly used in gel-like, cream-like, etc. Bases are available. It can also be applied to solid soaps that are manufactured in a dissolved state during manufacturing.

When an insoluble polymer powder was blended with sulfur into a skin external preparation using the method of the present invention, a skin external preparation with very good quality without sulfur aggregation was obtained. , sulfur coagulated and precipitated in the external skin preparation, causing a significant deterioration in quality.

[Example Series] Next, the present invention will be explained in detail with reference to Examples and Comparative Examples, but the present invention is not limited thereto.

<Example 1> Lauroyl glutamine 11 25 wt% sodium coconut oil jetanolamide 5PEG1500
15 Glycerin
25 Glyceryl monostearate 2 Purified water Amount to make the total 100 Fragrance
Appropriate amount of powdered sulfur
1. Polyethylene powder 3. After heating and melting all components except sulfur and polyethylene at 70'C, sulfur and polyethylene are charged. Sulfur and polyethylene powder are uniformly dispersed using a dispersing machine, and then a cooling process is performed to obtain a cleaning agent that stably contains sulfur.

Comparative Example 1> The formulation of Example 1 except that the polyethylene powder was removed,
Components other than sulfur were heated and dissolved at 70'C, then sulfur was added, followed by dispersion treatment and cooling treatment under the same conditions as in Example 1.

The facial cleansers of Example 1 and Comparative Example 1 were sampled immediately after the dispersion treatment (inside the production kettle), immediately after the start of the cooling treatment, at three points during the cooling treatment, and at each point just before the end (at the outlet of the cooling machine) to determine the sulfur content in the samples. The amount was measured.

Table 1 As is clearer from Table 1, in Comparative Example 1 in which only sulfur was blended, sulfur was uniformly dispersed immediately after the dispersion treatment, but agglomeration occurred during the time leading up to the cooling treatment.
Since the aggregates settle out at a high rate, it is of poor quality as an external preparation for the skin because the amount of sulfur is not constant.

In contrast, in Example 1, in accordance with the present invention, insoluble polymer powder (polyethylene powder in this example) was blended with sulfur, so that it could not only be carried out in the production kettle immediately after dispersion treatment but also not transferred to cooling treatment over time. An extremely excellent skin preparation with a constant sulfur content until the end of the cooling process can be obtained.

This is an effect related to the present invention.

<Example 2> Acylglutamic acid 83.4vtX monosodium (WJ product name Amisoft G5-11) Setanol 5.0 Purified water
9. ○Titanium oxide
0.1 Fragrance Appropriate amount Powdered sulfur 2.0 Nylon powder 0.5 Heat and melt the ingredients other than sulfur and nylon powder at 7000°C, then 50°C
Cool until cool.

Thereafter, sulfur and nylon powder are dispersed and then cooled to room temperature. Roughly knead with a blender to obtain a solid soap containing stably blended sulfur.

<Example 3> A. Purified water Amount to make the whole 100 Glycerin 10wt% Caustic potassium
0.283 cetanol
4 stearic acid
2.5 Vaseline 8 Liquid paraffin 10 Glyceryl monostearate 3 Isopropyl myristate 5
Ethylparaben 0.2 fragrance
Appropriate amount of C0 powder sulfur
0.5 cellulose powder
Component 5A and component B are respectively heated and dissolved at 70'C, and then B is added to A and emulsified. Monochi C
Add sulfur and cellulose powder, perform a dispersion treatment, and then perform a cooling treatment to obtain a skin preparation with a stable blend of sulfur.

<Example 4> A. Purified water Ethyl alcohol in an amount with the total as 100 5. ○wtχ Propylene glycol 10. ○Carboxyvinyl polymer
0.8B, powdered sulfur 5. ○Polypropylene powder 5. OC0 caustic potash
After 0.2 components A are dissolved at room temperature, powdered sulfur and polypropylene powder B are added. After the dispersion treatment, an alkali (C) is added to neutralize the mixture to obtain a gel-like skin preparation stably containing sulfur.

<Example 5> A, Vaseline 40wt% solid paraffin 2 Piece wax 2 POE (20) Cetyl ether 2 Stearic acid 2 Silicone oil 2 Squalane 35 Fragrance Appropriate amount B, Powdered sulfur 10 Powdered milk I! 3. Nylon powder 2.

The component A dissolved at 75°C is also cooled to 55°C. After that, sulfur, lactose, and nylon powder (B) are added and dispersed. Then, a cooling treatment is performed to obtain an ointment-like external preparation for skin containing a stable combination of sulfur.

Claims (1)

[Claims] A topical skin preparation that is characterized by containing sulfur and insoluble polymer powder.