JPS6124597A - 抗糖尿病剤 - Google Patents

抗糖尿病剤

Info

Publication number: JPS6124597A
Authority: JP; Japan
Prior art keywords: ginseng; ginsenoside; beta; antidiabetic agent; glucopyranoside
Prior art date: 1984-07-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP59145189A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0369328B2 (de

Inventor

Yuji Kawashima

川島　祐次

Hikokichi Oura

大浦　彦吉

Takako Yokozawa

隆子横澤

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Yamanouchi Pharmaceutical Co Ltd

Original Assignee

Yamanouchi Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-12

Filing date

1984-07-12

Publication date

1986-02-03

1984-07-12 Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd

1984-07-12 Priority to JP59145189A priority Critical patent/JPS6124597A/ja

1986-02-03 Publication of JPS6124597A publication Critical patent/JPS6124597A/ja

1991-10-31 Publication of JPH0369328B2 publication Critical patent/JPH0369328B2/ja

Status Granted legal-status Critical Current

Links

239000003472 antidiabetic agent Substances 0.000 title claims abstract description 6
229940125708 antidiabetic agent Drugs 0.000 title claims abstract description 6
239000004480 active ingredient Substances 0.000 claims description 2
235000008434 ginseng Nutrition 0.000 abstract description 9
241000208340 Araliaceae Species 0.000 abstract description 7
235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 abstract description 7
235000003140 Panax quinquefolius Nutrition 0.000 abstract description 7
229930182490 saponin Natural products 0.000 abstract description 7
150000007949 saponins Chemical class 0.000 abstract description 7
235000017709 saponins Nutrition 0.000 abstract description 7
230000000694 effects Effects 0.000 abstract description 6
229930182494 ginsenoside Natural products 0.000 abstract description 6
229940089161 ginsenoside Drugs 0.000 abstract description 6
NODILNFGTFIURN-GZPRDHCNSA-N ginsenoside Rb2 Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)O[C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(CC[C@H]4C(C)(C)[C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)CC[C@]4(C)[C@H]3C[C@H]2O)C)(C)CC1)O[C@@H]1OC[C@H](O)[C@H](O)[C@H]1O NODILNFGTFIURN-GZPRDHCNSA-N 0.000 abstract description 5
TXEWRVNOAJOINC-UHFFFAOYSA-N ginsenoside Rb2 Natural products CC(=CCCC(OC1OC(COC2OCC(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C)C TXEWRVNOAJOINC-UHFFFAOYSA-N 0.000 abstract description 5
PFSIGTQOILYIIU-UHFFFAOYSA-N ginsenoside Rb3 Natural products CC(=CCCC(C)(O)C1CCC2(C)C3CCC4C(C)(C)C(CCC4(C)C3CC(OC5OC(COC6OCC(O)C(O)C6O)C(O)C(O)C5O)C12C)OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C PFSIGTQOILYIIU-UHFFFAOYSA-N 0.000 abstract description 5
ZTQSADJAYQOCDD-UHFFFAOYSA-N ginsenoside-Rd2 Natural products C1CC(C2(CCC3C(C)(C)C(OC4C(C(O)C(O)C(CO)O4)O)CCC3(C)C2CC2O)C)(C)C2C1C(C)(CCC=C(C)C)OC(C(C(O)C1O)O)OC1COC1OCC(O)C(O)C1O ZTQSADJAYQOCDD-UHFFFAOYSA-N 0.000 abstract description 5
239000000126 substance Substances 0.000 abstract description 5
230000002218 hypoglycaemic effect Effects 0.000 abstract description 4
239000001397 quillaja saponaria molina bark Substances 0.000 abstract description 4
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract description 3
229920002261 Corn starch Polymers 0.000 abstract description 2
229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract description 2
240000004371 Panax ginseng Species 0.000 abstract description 2
235000002789 Panax ginseng Nutrition 0.000 abstract description 2
239000008120 corn starch Substances 0.000 abstract description 2
239000001863 hydroxypropyl cellulose Substances 0.000 abstract description 2
235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract description 2
239000008101 lactose Substances 0.000 abstract description 2
239000000203 mixture Substances 0.000 abstract description 2
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 2
SRBFZHDQGSBBOR-QMKXCQHVSA-N alpha-L-arabinopyranose Chemical compound O[C@H]1CO[C@@H](O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-QMKXCQHVSA-N 0.000 abstract 1
239000011230 binding agent Substances 0.000 abstract 1
244000000626 Daucus carota Species 0.000 description 6
235000002767 Daucus carota Nutrition 0.000 description 6
238000000034 method Methods 0.000 description 6
210000004369 blood Anatomy 0.000 description 5
239000008280 blood Substances 0.000 description 5
241000700159 Rattus Species 0.000 description 4
206010012601 diabetes mellitus Diseases 0.000 description 4
239000008187 granular material Substances 0.000 description 4
239000007924 injection Substances 0.000 description 4
238000002347 injection Methods 0.000 description 4
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
230000003178 anti-diabetic effect Effects 0.000 description 3
230000037396 body weight Effects 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
239000000243 solution Substances 0.000 description 3
208000024891 symptom Diseases 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
241000699670 Mus sp. Species 0.000 description 2
HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 2
238000009395 breeding Methods 0.000 description 2
230000001488 breeding effect Effects 0.000 description 2
239000008103 glucose Substances 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
239000002504 physiological saline solution Substances 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
241001530105 Anax Species 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108010015776 Glucose oxidase Proteins 0.000 description 1
239000004366 Glucose oxidase Substances 0.000 description 1
125000003572 L-arabinopyranosyl group Chemical group [H]O[C@@]1([H])C([H])([H])OC([H])(*)[C@]([H])(O[H])[C@@]1([H])O[H] 0.000 description 1
230000005856 abnormality Effects 0.000 description 1
244000309464 bull Species 0.000 description 1
239000002775 capsule Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000007979 citrate buffer Substances 0.000 description 1
229940099112 cornstarch Drugs 0.000 description 1
230000034994 death Effects 0.000 description 1
231100000517 death Toxicity 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000013551 empirical research Methods 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
230000003203 everyday effect Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229940116332 glucose oxidase Drugs 0.000 description 1
235000019420 glucose oxidase Nutrition 0.000 description 1
239000003292 glue Substances 0.000 description 1
230000003345 hyperglycaemic effect Effects 0.000 description 1
201000001421 hyperglycemia Diseases 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
230000007774 longterm Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
239000008024 pharmaceutical diluent Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000037081 physical activity Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000820 toxicity test Toxicity 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
239000002023 wood Substances 0.000 description 1

Landscapes

Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)

JP59145189A 1984-07-12 1984-07-12 抗糖尿病剤 Granted JPS6124597A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP59145189A JPS6124597A (ja)	1984-07-12	1984-07-12	抗糖尿病剤

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP59145189A JPS6124597A (ja)	1984-07-12	1984-07-12	抗糖尿病剤

Publications (2)

Publication Number	Publication Date
JPS6124597A true JPS6124597A (ja)	1986-02-03
JPH0369328B2 JPH0369328B2 (de)	1991-10-31

Family

ID=15379480

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP59145189A Granted JPS6124597A (ja)	1984-07-12	1984-07-12	抗糖尿病剤

Country Status (1)

Country	Link
JP (1)	JPS6124597A (de)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999063979A3 (en) *	1998-06-08	2000-03-16	Sambasiva R Chavali	Inhibition of δ-9-desaturase activity by saponins
WO2002038166A3 (en) *	2000-11-07	2003-07-10	Univ Chicago	Ginseng berry extracts and pharmaceutical compositions therefrom
KR100735573B1 (ko)	2005-10-06	2007-07-04	주식회사 비티진	진세노사이드를 유효성분으로 하는 혈당강하제 조성물
WO2011002033A1 (ja)	2009-06-30	2011-01-06	ライオン株式会社	糖代謝改善剤及び糖代謝改善組成物
JP2011026314A (ja) *	2009-06-30	2011-02-10	Lion Corp	糖代謝改善剤及び糖代謝改善組成物
JP2011026313A (ja) *	2009-06-30	2011-02-10	Lion Corp	糖代謝改善剤及び糖代謝改善組成物
CN104800558A (zh) *	2015-04-27	2015-07-29	唐玉厚	一种治疗糖尿病的药物
CN104857367A (zh) *	2015-05-13	2015-08-26	柳州市耕青科技有限公司	一种降血糖的中药饮方

1984
- 1984-07-12 JP JP59145189A patent/JPS6124597A/ja active Granted

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999063979A3 (en) *	1998-06-08	2000-03-16	Sambasiva R Chavali	Inhibition of δ-9-desaturase activity by saponins
WO2002038166A3 (en) *	2000-11-07	2003-07-10	Univ Chicago	Ginseng berry extracts and pharmaceutical compositions therefrom
KR100735573B1 (ko)	2005-10-06	2007-07-04	주식회사 비티진	진세노사이드를 유효성분으로 하는 혈당강하제 조성물
WO2011002033A1 (ja)	2009-06-30	2011-01-06	ライオン株式会社	糖代謝改善剤及び糖代謝改善組成物
JP2011026314A (ja) *	2009-06-30	2011-02-10	Lion Corp	糖代謝改善剤及び糖代謝改善組成物
JP2011026313A (ja) *	2009-06-30	2011-02-10	Lion Corp	糖代謝改善剤及び糖代謝改善組成物
KR20160132134A (ko)	2009-06-30	2016-11-16	라이온 가부시키가이샤	당 대사 개선제 및 당 대사 개선 조성물
CN104800558A (zh) *	2015-04-27	2015-07-29	唐玉厚	一种治疗糖尿病的药物
CN104857367A (zh) *	2015-05-13	2015-08-26	柳州市耕青科技有限公司	一种降血糖的中药饮方

Also Published As

Publication number	Publication date
JPH0369328B2 (de)	1991-10-31

Publication	Publication Date	Title
CN106074971B (zh)	2020-04-17	一种降血糖中药组合物及制备方法与应用
JP2002526379A (ja)	2002-08-20	インシュリン活性を増強する組成物およびその方法
US7985848B2 (en)	2011-07-26	Pharmaceutical composition for preventing and treating diabetes or glucose control abnormality comprising ginsenosides
US4985248A (en)	1991-01-15	Pharmaceutical composition containing a safe extracts of fruits and vegetables for the treating and preventing of diabetes
US5980902A (en)	1999-11-09	Compositions for treating and preventing diabetes, impaired glucose tolerance and related symptoms, and methods for preparing and using such compositions
CN103520199A (zh)	2014-01-22	枸杞多糖在治疗糖尿病药物中的应用
EP2172206A1 (de)	2010-04-07	Verfahren für einen sequoyitol enthaltenden extrakt aus dem genus trifolium, sojabohne und ginkgo biloba und seine anwendung
JPS6124597A (ja)	1986-02-03	抗糖尿病剤
CN1294912A (zh)	2001-05-16	一类新型降低血糖化合物
Jouad et al.	2003	Cholesterol-lowering activity of the aqueous extract of Spergularia purpurea in normal and recent-onset diabetic rats
CN102716135B (zh)	2015-11-11	羽扇豆酮在制备预防或治疗糖尿病的产品中的应用
US5086043A (en)	1992-02-04	Production of Saponins of Lichi
KR20030023232A (ko)	2003-03-19	인삼 또는 돌외로부터 사포닌을 추출하는 방법 및 이방법에 따라 추출된 사포닌을 함유하는 식품
CN112494502B (zh)	2023-07-25	一种用于血虚证补血的糖类组合物
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RU2114617C1 (ru)	1998-07-10	Антидиабетическое средство на основе янтарной кислоты
Yokozawa et al.	1989	The effect of ginsenoside-Rb2 on nitrogen balance
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KR100256867B1 (ko)	2000-05-15	엘-무스콘의 의약용도
JPS5948421A (ja)	1984-03-19	抗高脂血症剤
Saiyad Moinali et al.	2013	To investigate antidiabetic potential of Martynia annua linn. flower extracts in wistar rats
US20110071225A1 (en)	2011-03-24	Method for obtaining a sequoyitol-containing extract from genus nephrolepis and uses thereof
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US20100197803A1 (en)	2010-08-05	Method for obtaining a sequoyitol-containing extract from a plant of the genus of trifolium, leguminosae or ginkoaceae and uses thereof
KR100543352B1 (ko)	2006-01-20	당뇨병 치료에 효능이 있는 혼합 생약재 추출물