JPS6317811B2 - - Google Patents

Info

Publication number: JPS6317811B2
Authority: JP; Japan
Prior art keywords: ethyl alcohol; soluble; concentration; supernatant; minutes
Prior art date: 1981-12-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP19815181A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5899416A (ja

Inventor

Makoto Enomoto

Yoshio Ueno

Yosuke Kawasaki

Fusae Iida

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

KYOKUTOO INTAANASHONARU KK

Original Assignee

KYOKUTOO INTAANASHONARU KK

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-12-09

Filing date

1981-12-09

Publication date

1988-04-15

1981-12-09 Application filed by KYOKUTOO INTAANASHONARU KK filed Critical KYOKUTOO INTAANASHONARU KK

1981-12-09 Priority to JP19815181A priority Critical patent/JPS5899416A/ja

1983-06-13 Publication of JPS5899416A publication Critical patent/JPS5899416A/ja

1988-04-15 Publication of JPS6317811B2 publication Critical patent/JPS6317811B2/ja

Status Granted legal-status Critical Current

Links

LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 46
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 28
235000019441 ethanol Nutrition 0.000 claims description 23
206010020751 Hypersensitivity Diseases 0.000 claims description 19
208000030961 allergic reaction Diseases 0.000 claims description 14
235000014655 lactic acid Nutrition 0.000 claims description 14
239000004310 lactic acid Substances 0.000 claims description 14
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238000000926 separation method Methods 0.000 claims description 9
238000004519 manufacturing process Methods 0.000 claims description 8
239000000126 substance Substances 0.000 claims description 8
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239000000203 mixture Substances 0.000 claims description 4
239000007864 aqueous solution Substances 0.000 claims description 3
239000006228 supernatant Substances 0.000 description 31
230000001580 bacterial effect Effects 0.000 description 15
239000002244 precipitate Substances 0.000 description 14
210000004027 cell Anatomy 0.000 description 13
238000000034 method Methods 0.000 description 13
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
241000194035 Lactococcus lactis Species 0.000 description 11
235000014897 Streptococcus lactis Nutrition 0.000 description 11
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239000000843 powder Substances 0.000 description 10
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WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
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OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
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FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
208000004262 Food Hypersensitivity Diseases 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
238000003794 Gram staining Methods 0.000 description 2
229920001202 Inulin Polymers 0.000 description 2
241000186660 Lactobacillus Species 0.000 description 2
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
102000004316 Oxidoreductases Human genes 0.000 description 2
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VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
230000002052 anaphylactic effect Effects 0.000 description 2
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229920000159 gelatin Polymers 0.000 description 2
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235000011852 gelatine desserts Nutrition 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 2
229940029339 inulin Drugs 0.000 description 2
229940039696 lactobacillus Drugs 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
244000005700 microbiome Species 0.000 description 2
230000000877 morphologic effect Effects 0.000 description 2
230000004899 motility Effects 0.000 description 2
230000003287 optical effect Effects 0.000 description 2
230000001766 physiological effect Effects 0.000 description 2
230000002265 prevention Effects 0.000 description 2
239000000047 product Substances 0.000 description 2
210000002345 respiratory system Anatomy 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
230000035939 shock Effects 0.000 description 2
235000021055 solid food Nutrition 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
239000000725 suspension Substances 0.000 description 2
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239000008399 tap water Substances 0.000 description 2
235000020679 tap water Nutrition 0.000 description 2
206010027654 Allergic conditions Diseases 0.000 description 1
239000004382 Amylase Substances 0.000 description 1
102000013142 Amylases Human genes 0.000 description 1
108010065511 Amylases Proteins 0.000 description 1
206010002198 Anaphylactic reaction Diseases 0.000 description 1
244000063299 Bacillus subtilis Species 0.000 description 1
235000014469 Bacillus subtilis Nutrition 0.000 description 1
241000193403 Clostridium Species 0.000 description 1
206010010904 Convulsion Diseases 0.000 description 1
206010011703 Cyanosis Diseases 0.000 description 1
206010012438 Dermatitis atopic Diseases 0.000 description 1
208000019872 Drug Eruptions Diseases 0.000 description 1
241000194033 Enterococcus Species 0.000 description 1
206010016946 Food allergy Diseases 0.000 description 1
208000018522 Gastrointestinal disease Diseases 0.000 description 1
208000031361 Hiccup Diseases 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
241000194036 Lactococcus Species 0.000 description 1
206010033799 Paralysis Diseases 0.000 description 1
206010036790 Productive cough Diseases 0.000 description 1
206010038687 Respiratory distress Diseases 0.000 description 1
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238000000692 Student's t-test Methods 0.000 description 1
102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
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239000002671 adjuvant Substances 0.000 description 1
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235000019418 amylase Nutrition 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
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230000000721 bacterilogical effect Effects 0.000 description 1
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239000008280 blood Substances 0.000 description 1
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239000007853 buffer solution Substances 0.000 description 1
208000029771 childhood onset asthma Diseases 0.000 description 1
230000036461 convulsion Effects 0.000 description 1
238000012258 culturing Methods 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
208000010643 digestive system disease Diseases 0.000 description 1
229940079919 digestives enzyme preparation Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000012530 fluid Substances 0.000 description 1
208000018685 gastrointestinal system disease Diseases 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000008187 granular material Substances 0.000 description 1
239000006458 gyp medium Substances 0.000 description 1
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102000018358 immunoglobulin Human genes 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
210000003141 lower extremity Anatomy 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000027939 micturition Effects 0.000 description 1
239000006199 nebulizer Substances 0.000 description 1
231100000957 no side effect Toxicity 0.000 description 1
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239000002504 physiological saline solution Substances 0.000 description 1
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210000003802 sputum Anatomy 0.000 description 1
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239000003381 stabilizer Substances 0.000 description 1
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Landscapes

Medicines Containing Material From Animals Or Micro-Organisms (AREA)

JP19815181A 1981-12-09 1981-12-09 アレルギ−反応抑制剤及びその製法 Granted JPS5899416A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP19815181A JPS5899416A (ja)	1981-12-09	1981-12-09	アレルギ−反応抑制剤及びその製法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP19815181A JPS5899416A (ja)	1981-12-09	1981-12-09	アレルギ−反応抑制剤及びその製法

Publications (2)

Publication Number	Publication Date
JPS5899416A JPS5899416A (ja)	1983-06-13
JPS6317811B2 true JPS6317811B2 (cs)	1988-04-15

Family

ID=16386301

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP19815181A Granted JPS5899416A (ja)	1981-12-09	1981-12-09	アレルギ−反応抑制剤及びその製法

Country Status (1)

Country	Link
JP (1)	JPS5899416A (cs)

1981
- 1981-12-09 JP JP19815181A patent/JPS5899416A/ja active Granted

Also Published As

Publication number	Publication date
JPS5899416A (ja)	1983-06-13

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