JPS63196576A - フラルナフトキノン誘導体と制癌剤及びその製造方法 - Google Patents

フラルナフトキノン誘導体と制癌剤及びその製造方法

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Publication number
JPS63196576A
JPS63196576A JP2859587A JP2859587A JPS63196576A JP S63196576 A JPS63196576 A JP S63196576A JP 2859587 A JP2859587 A JP 2859587A JP 2859587 A JP2859587 A JP 2859587A JP S63196576 A JPS63196576 A JP S63196576A
Authority
JP
Japan
Prior art keywords
furalnaphthoquinone
tables
formulas
formula
chemical formulas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2859587A
Other languages
English (en)
Inventor
Tetsuo Ikegawa
哲郎 池川
Nobuo Ikegawa
池川　信夫
Masuo Tsukada
塚田　益男
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP2859587A priority Critical patent/JPS63196576A/ja
Publication of JPS63196576A publication Critical patent/JPS63196576A/ja
Pending legal-status Critical Current

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  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。

Description

【発明の詳細な説明】 氏名　　　塚　１）益　男

Claims (3)

    【特許請求の範囲】
  1. （１）次の一般式 ▲数式、化学式、表等があります▼ （式中Ｒは−ＯＲ′、−Ｒ′、▲数式、化学式、表等が
    あります▼、▲数式、化学式、表等があります▼で Ｒ′は水素原子、アルキル基及び／又はハイドロオキシ
    アルキル基）で表わされるフラルナフトキノン誘導体。
  2. （２）次の一般式 ▲数式、化学式、表等があります▼ （式中Ｒは−ＯＲ′、−Ｒ′、▲数式、化学式、表等が
    あります▼、▲数式、化学式、表等があります▼で Ｒ′は水素原子、アルキル基及び／又はハイドロオキシ
    アルキル基）で表わされるフラルナフトキノン誘導体を
    有効成分とする制癌剤。
  3. （３）高等植物イッペイ・ホッシュを有機溶媒又は水で
    抽出し、クロマトグラフによる精製工程を経て次の一般
    式で表わされるフラルナフトキノン誘導体を製造する方
    法。 ▲数式、化学式、表等があります▼ （式中Ｒは−ＯＲ′、−Ｒ′、▲数式、化学式、表等が
    あります▼、▲数式、化学式、表等があります▼で Ｒ′は水素原子、アルキル基及び／又はハイドロオキシ
    アルキル基）
JP2859587A 1987-02-10 1987-02-10 フラルナフトキノン誘導体と制癌剤及びその製造方法 Pending JPS63196576A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2859587A JPS63196576A (ja) 1987-02-10 1987-02-10 フラルナフトキノン誘導体と制癌剤及びその製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2859587A JPS63196576A (ja) 1987-02-10 1987-02-10 フラルナフトキノン誘導体と制癌剤及びその製造方法

Publications (1)

Publication Number Publication Date
JPS63196576A true JPS63196576A (ja) 1988-08-15

Family

ID=12252944

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2859587A Pending JPS63196576A (ja) 1987-02-10 1987-02-10 フラルナフトキノン誘導体と制癌剤及びその製造方法

Country Status (1)

Country Link
JP (1) JPS63196576A (ja)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994006786A1 (en) * 1992-09-18 1994-03-31 Taheebo Japan Co., Ltd. 2-(1-HYDROXYETHYL)-5-HYDROXYNAPHTO[2,3-b]FURAN-4,9-DIONE AND ANTITUMOR AGENTS COMPRISING THIS COMPOUND
US7538234B2 (en) 2007-05-31 2009-05-26 Taheebo Japan Co., Ltd. Preparation of Optically active 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4, 9-diones having anticancer activities
JP2010539095A (ja) * 2007-09-10 2010-12-16 ボストン バイオメディカル， インコーポレイテッド 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
US7910752B2 (en) 2005-03-16 2011-03-22 Taheebo Japan Co., Ltd. Anticancer compound, intermediate therefor, and processes for producing these
CN107973788A (zh) * 2018-01-09 2018-05-01 沈阳药科大学 Bbi608衍生物及其制备与用途
WO2018096401A1 (en) 2016-11-22 2018-05-31 Hitoshi Ban New naphtho[2,3-b]furan derivatives
US10017488B2 (en) 2014-02-07 2018-07-10 Boston Biomedical, Inc. 3-substituted carbonyl-naphtho[2,3-B]furane derivative or pharmaceutically acceptable salt thereof
US10543189B2 (en) 2013-04-09 2020-01-28 Boston Biomedical, Inc. 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
US10646464B2 (en) 2017-05-17 2020-05-12 Boston Biomedical, Inc. Methods for treating cancer
WO2020161959A1 (ja) * 2019-02-06 2020-08-13 タヒボジャパン株式会社 抗菌及び抗ウイルス活性を有するナフトキノン化合物及びその医薬用途
US10906914B2 (en) 2015-01-08 2021-02-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Furoquinolinediones as inhibitors of TDP2
US10934309B2 (en) 2014-03-31 2021-03-02 Sumitomo Dainippon Pharma Oncology, Inc. Tricyclic quinone derivative
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TETRAHEDRON LETTERS=1986 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06145162A (ja) * 1992-09-18 1994-05-24 Tahibo Japan Kk ２−（１−ヒドロキシエチル）−５−ヒドロキシナフト［２，３−ｂ］フラン−４，９−ジオンおよびそれを含有する抗癌剤
WO1994006786A1 (en) * 1992-09-18 1994-03-31 Taheebo Japan Co., Ltd. 2-(1-HYDROXYETHYL)-5-HYDROXYNAPHTO[2,3-b]FURAN-4,9-DIONE AND ANTITUMOR AGENTS COMPRISING THIS COMPOUND
US7910752B2 (en) 2005-03-16 2011-03-22 Taheebo Japan Co., Ltd. Anticancer compound, intermediate therefor, and processes for producing these
US7538234B2 (en) 2007-05-31 2009-05-26 Taheebo Japan Co., Ltd. Preparation of Optically active 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4, 9-diones having anticancer activities
US10377731B2 (en) 2007-09-10 2019-08-13 Boston Biomedical, Inc. Compositions and methods for cancer treatment
JP2010539095A (ja) * 2007-09-10 2010-12-16 ボストン バイオメディカル， インコーポレイテッド 新規のＳｔａｔ３経路阻害剤及び癌幹細胞阻害剤
CN105963289A (zh) * 2007-09-10 2016-09-28 北京强新生物科技有限公司 一类新的stat3通路抑制剂和癌干细胞通路抑制剂
US10851075B2 (en) 2007-09-10 2020-12-01 Sumitomo Dainippon Pharma Oncology, Inc. Stat3 pathway inhibitors and cancer stem cell inhibitors
US10543189B2 (en) 2013-04-09 2020-01-28 Boston Biomedical, Inc. 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
US10017488B2 (en) 2014-02-07 2018-07-10 Boston Biomedical, Inc. 3-substituted carbonyl-naphtho[2,3-B]furane derivative or pharmaceutically acceptable salt thereof
US10683274B2 (en) 2014-02-07 2020-06-16 Boston Biomedical, Inc. 3-substituted carbonyl-naphtho[2,3-B]furane derivative or pharmaceutically acceptable salt thereof
US10934309B2 (en) 2014-03-31 2021-03-02 Sumitomo Dainippon Pharma Oncology, Inc. Tricyclic quinone derivative
US10906914B2 (en) 2015-01-08 2021-02-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Furoquinolinediones as inhibitors of TDP2
US11999747B2 (en) 2015-01-08 2024-06-04 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPT OF HEALTH & HUMAN SERVICES Furoquinolinediones as inhibitors of TDP2
WO2018096401A1 (en) 2016-11-22 2018-05-31 Hitoshi Ban New naphtho[2,3-b]furan derivatives
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
US10646464B2 (en) 2017-05-17 2020-05-12 Boston Biomedical, Inc. Methods for treating cancer
CN107973788A (zh) * 2018-01-09 2018-05-01 沈阳药科大学 Bbi608衍生物及其制备与用途
WO2020161959A1 (ja) * 2019-02-06 2020-08-13 タヒボジャパン株式会社 抗菌及び抗ウイルス活性を有するナフトキノン化合物及びその医薬用途

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