JPS63209746A - リポソ−ムの製法 - Google Patents

リポソ−ムの製法

Info

Publication number: JPS63209746A
Authority: JP; Japan
Prior art keywords: suspension; liposome; liposomes; inert gas; solvent
Prior art date: 1987-02-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP62042827A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0553537B2 (de

Inventor

Kazuhiko Suzuki

鈴木　一比好

Keisuke Sakaguchi

坂口　圭介

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Terumo Corp

Original Assignee

Terumo Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-27

Filing date

1987-02-27

Publication date

1988-08-31

1987-02-27 Application filed by Terumo Corp filed Critical Terumo Corp

1987-02-27 Priority to JP62042827A priority Critical patent/JPS63209746A/ja

1988-02-26 Priority to DE8888902213T priority patent/DE3872875T2/de

1988-02-26 Priority to EP88902213A priority patent/EP0357773B1/de

1988-02-26 Priority to AU13648/88A priority patent/AU608304B2/en

1988-02-26 Priority to PCT/JP1988/000208 priority patent/WO1988006437A1/ja

1988-02-26 Priority to US07/408,485 priority patent/US5049391A/en

1988-08-31 Publication of JPS63209746A publication Critical patent/JPS63209746A/ja

1993-08-10 Publication of JPH0553537B2 publication Critical patent/JPH0553537B2/ja

Status Granted legal-status Critical Current

Links

239000002502 liposome Substances 0.000 title claims abstract description 63
238000004519 manufacturing process Methods 0.000 title claims description 21
239000000725 suspension Substances 0.000 claims abstract description 42
150000002632 lipids Chemical class 0.000 claims abstract description 19
239000011261 inert gas Substances 0.000 claims abstract description 16
239000002904 solvent Substances 0.000 claims abstract description 8
239000007864 aqueous solution Substances 0.000 claims description 25
238000000034 method Methods 0.000 claims description 17
239000000243 solution Substances 0.000 claims description 13
239000003960 organic solvent Substances 0.000 claims description 7
239000007789 gas Substances 0.000 claims description 6
239000003995 emulsifying agent Substances 0.000 claims description 4
239000000203 mixture Substances 0.000 claims description 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract description 2
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 abstract description 2
239000000787 lecithin Substances 0.000 abstract description 2
229940067606 lecithin Drugs 0.000 abstract description 2
235000010445 lecithin Nutrition 0.000 abstract description 2
150000008104 phosphatidylethanolamines Chemical class 0.000 abstract description 2
150000003904 phospholipids Chemical group 0.000 abstract description 2
238000004821 distillation Methods 0.000 abstract 3
102000001554 Hemoglobins Human genes 0.000 description 19
108010054147 Hemoglobins Proteins 0.000 description 19
239000012528 membrane Substances 0.000 description 10
239000000126 substance Substances 0.000 description 9
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
238000002360 preparation method Methods 0.000 description 6
210000003743 erythrocyte Anatomy 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
238000007796 conventional method Methods 0.000 description 4
239000002994 raw material Substances 0.000 description 4
239000004094 surface-active agent Substances 0.000 description 4
239000010409 thin film Substances 0.000 description 4
PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 3
239000002504 physiological saline solution Substances 0.000 description 3
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
235000002597 Solanum melongena Nutrition 0.000 description 2
ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 2
AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
239000000969 carrier Substances 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
239000011362 coarse particle Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
238000000502 dialysis Methods 0.000 description 2
229910001873 dinitrogen Inorganic materials 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
238000005984 hydrogenation reaction Methods 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
239000002245 particle Substances 0.000 description 2
239000012466 permeate Substances 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000000746 purification Methods 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
238000002525 ultrasonication Methods 0.000 description 2
OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
239000000232 Lipid Bilayer Substances 0.000 description 1
239000005642 Oleic acid Substances 0.000 description 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
229930182558 Sterol Natural products 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
229940041181 antineoplastic drug Drugs 0.000 description 1
229910052786 argon Inorganic materials 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000012937 correction Methods 0.000 description 1
238000010908 decantation Methods 0.000 description 1
238000007599 discharging Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000005538 encapsulation Methods 0.000 description 1
210000002472 endoplasmic reticulum Anatomy 0.000 description 1
239000010408 film Substances 0.000 description 1
239000012510 hollow fiber Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
239000000693 micelle Substances 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
235000021313 oleic acid Nutrition 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
239000011148 porous material Substances 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000000047 product Substances 0.000 description 1
239000008349 purified phosphatidyl choline Substances 0.000 description 1
239000012744 reinforcing agent Substances 0.000 description 1
238000011160 research Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
238000009210 therapy by ultrasound Methods 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
238000005199 ultracentrifugation Methods 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
238000001291 vacuum drying Methods 0.000 description 1
230000002747 voluntary effect Effects 0.000 description 1
-1 β-glucurondase Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Epidemiology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dispersion Chemistry (AREA)
Manufacturing Of Micro-Capsules (AREA)
Medicinal Preparation (AREA)

JP62042827A 1987-02-27 1987-02-27 リポソ−ムの製法 Granted JPS63209746A (ja)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
JP62042827A JPS63209746A (ja)	1987-02-27	1987-02-27	リポソ−ムの製法
DE8888902213T DE3872875T2 (de)	1987-02-27	1988-02-26	Verfahren zur herstellung von liposomen.
EP88902213A EP0357773B1 (de)	1987-02-27	1988-02-26	Verfahren zur herstellung von liposomen
AU13648/88A AU608304B2 (en)	1987-02-27	1988-02-26	Process for preparing liposome
PCT/JP1988/000208 WO1988006437A1 (fr)	1987-02-27	1988-02-26	Procede de preparation de liposomes
US07/408,485 US5049391A (en)	1987-02-27	1988-02-26	Liposome encapsulated hemoglobin

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP62042827A JPS63209746A (ja)	1987-02-27	1987-02-27	リポソ−ムの製法

Publications (2)

Publication Number	Publication Date
JPS63209746A true JPS63209746A (ja)	1988-08-31
JPH0553537B2 JPH0553537B2 (de)	1993-08-10

Family

ID=12646793

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP62042827A Granted JPS63209746A (ja)	1987-02-27	1987-02-27	リポソ−ムの製法

Country Status (1)

Country	Link
JP (1)	JPS63209746A (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005225770A (ja) *	2004-02-10	2005-08-25	Japan Health Science Foundation	中空糸透析カラムを利用したリポソームの製造方法
WO2012137834A1 (ja) *	2011-04-04	2012-10-11	学校法人早稲田大学	小胞体の製造方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9235075B2 (en)	2012-05-22	2016-01-12	Kent Displays Incorporated	Electronic display with patterned layer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5989620A (ja) *	1982-10-05	1984-05-23	パルフユ−ム・クリスチヤン・デイオ−ル	水和脂質カメラ相分散液の均質化方法及びその方法により製造される分散液

1987
- 1987-02-27 JP JP62042827A patent/JPS63209746A/ja active Granted

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5989620A (ja) *	1982-10-05	1984-05-23	パルフユ−ム・クリスチヤン・デイオ−ル	水和脂質カメラ相分散液の均質化方法及びその方法により製造される分散液

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005225770A (ja) *	2004-02-10	2005-08-25	Japan Health Science Foundation	中空糸透析カラムを利用したリポソームの製造方法
WO2012137834A1 (ja) *	2011-04-04	2012-10-11	学校法人早稲田大学	小胞体の製造方法

Also Published As

Publication number	Publication date
JPH0553537B2 (de)	1993-08-10

Legal Events

Date	Code	Title	Description
2006-08-10	LAPS	Cancellation because of no payment of annual fees

Publication	Publication Date	Title
US4394372A (en)	1983-07-19	Process for making lipid membrane structures
US4776991A (en)	1988-10-11	Scaled-up production of liposome-encapsulated hemoglobin
US4911929A (en)	1990-03-27	Blood substitute comprising liposome-encapsulated hemoglobin
EP0036676B2 (de)	1990-09-19	Verfahren zur Herstellung von Liposomen gleicher Grösse und so hergestellte Liposome
US4994213A (en)	1991-02-19	Method of preparing lipid structures
Alavi et al.	2022	Conventional and novel methods for the preparation of micro and nanoliposomes
JPH0639274A (ja)	1994-02-15	リポソーム懸濁液の安定化法
EP0055576A1 (de)	1982-07-07	Verfahren zur Herstellung von Strukturen aus lipoiden Membranen
JPH0753661B2 (ja)	1995-06-07	プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
JPS59134712A (ja)	1984-08-02	多薄層リピド胞の製造法
US6217899B1 (en)	2001-04-17	Liposomes preparation method and plant
JPH08505312A (ja)	1996-06-11	液状分散系を製造する方法及び装置
EP0792143A1 (de)	1997-09-03	Verfahren und gerät zum herstellen von liposomen die hydrophobe arzneistoffe enthalten
JPH01501479A (ja)	1989-05-25	リン脂質組成物
KR20040063901A (ko)	2004-07-14	고압에서 소포체를 압출하는 방법 및 장치
EP0357773B1 (de)	1992-07-15	Verfahren zur herstellung von liposomen
JPS63209746A (ja)	1988-08-31	リポソ−ムの製法
JPH02502719A (ja)	1990-08-30	薬理学的剤‐脂質溶液製剤
Beh et al.	2014	Formation of nanocarrier systems by dense gas processing
JP2005298407A (ja)	2005-10-27	ポリカチオン修飾リポソームおよびその製造法
JPS6366117A (ja)	1988-03-24	リポソ−ムおよびその製法
WO1989011335A1 (en)	1989-11-30	Preparation of uniform-size liposomes and other lipid structures
JP2013075839A (ja)	2013-04-25	脂質水和物およびリポソームの製造方法
Sathe et al.	2021	Liposomes: an overview
JPH082780B2 (ja)	1996-01-17	リポソームの製法

JPS63209746A - リポソ−ムの製法 - Google Patents

Info

Links

Classifications

Landscapes

Priority Applications (6)

Applications Claiming Priority (1)

Publications (2)

Family

ID=12646793

Family Applications (1)

Country Status (1)

Cited By (2)

Families Citing this family (1)

Citations (1)

Patent Citations (1)

Cited By (2)

Also Published As

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