JPS6445331A - Production of adjacently substituted ketones - Google Patents
Production of adjacently substituted ketonesInfo
- Publication number
- JPS6445331A JPS6445331A JP63176940A JP17694088A JPS6445331A JP S6445331 A JPS6445331 A JP S6445331A JP 63176940 A JP63176940 A JP 63176940A JP 17694088 A JP17694088 A JP 17694088A JP S6445331 A JPS6445331 A JP S6445331A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- protected
- expressed
- reacted
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002576 ketones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 239000005749 Copper compound Substances 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 239000003905 agrochemical Substances 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001880 copper compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- TUQOTMZNTHZOKS-UHFFFAOYSA-N tributylphosphine Chemical compound CCCCP(CCCC)CCCC TUQOTMZNTHZOKS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE:To obtain the titled compound having various kind of organic groups introduced at alpha position and beta position and useful as medicine, agricultural chemical and perfume or intermediates thereof in high yield, by reacting a alpha,beta-unsaturated carbonyl compound with an organic copper compound and then reacting the resultant product with aldehydes. CONSTITUTION:Cyclopentenones expressed by formula I (Q is H or protected OH; R2' and R4' are H or lower alkyl) is reacted with a compound expressed by the formula RACu (RA is 1-20C alkyl or alkenyl capable of having protected OH) in an aprotonic inert organic medium in the presence of a trihydrocarbon phosphine (preferably tri-n-butylphosphine) preferably at -40--78 deg.C and the resultant product is reacted with a compound expressed by the Rc CHO (Rc is H or 1-20C hydrocarbon group capable of having protected OH or carboxyl) in the presence of a Lewis acid at ambient temperature - -78 deg.C to provide the aimed compound.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63176940A JPS6445331A (en) | 1988-07-18 | 1988-07-18 | Production of adjacently substituted ketones |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63176940A JPS6445331A (en) | 1988-07-18 | 1988-07-18 | Production of adjacently substituted ketones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6445331A true JPS6445331A (en) | 1989-02-17 |
| JPH036127B2 JPH036127B2 (en) | 1991-01-29 |
Family
ID=16022399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63176940A Granted JPS6445331A (en) | 1988-07-18 | 1988-07-18 | Production of adjacently substituted ketones |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6445331A (en) |
-
1988
- 1988-07-18 JP JP63176940A patent/JPS6445331A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH036127B2 (en) | 1991-01-29 |
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