JPWO2012173207A1 - 網膜細胞への分化誘導方法 - Google Patents

網膜細胞への分化誘導方法 Download PDF

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Publication number
JPWO2012173207A1
JPWO2012173207A1 JP2013520588A JP2013520588A JPWO2012173207A1 JP WO2012173207 A1 JPWO2012173207 A1 JP WO2012173207A1 JP 2013520588 A JP2013520588 A JP 2013520588A JP 2013520588 A JP2013520588 A JP 2013520588A JP WO2012173207 A1 JPWO2012173207 A1 JP WO2012173207A1
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cells
culture
medium
retinal progenitor
retinal
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Japanese (ja)
Inventor
政代 高橋
政代 高橋
理志 岡本
理志 岡本
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RIKEN
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RIKEN
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013520588A 2011-06-14 2012-06-14 網膜細胞への分化誘導方法 Pending JPWO2012173207A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2013520588A JPWO2012173207A1 (ja) 2011-06-14 2012-06-14 網膜細胞への分化誘導方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011132712 2011-06-14
JP2011132712 2011-06-14
JP2013520588A JPWO2012173207A1 (ja) 2011-06-14 2012-06-14 網膜細胞への分化誘導方法

Publications (1)

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JPWO2012173207A1 true JPWO2012173207A1 (ja) 2015-02-23

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JP2013520588A Pending JPWO2012173207A1 (ja) 2011-06-14 2012-06-14 網膜細胞への分化誘導方法

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JP (1) JPWO2012173207A1 (fr)
WO (1) WO2012173207A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3070162B1 (fr) 2013-11-11 2019-09-18 Sumitomo Chemical Company, Limited Procédé de production de cellules épithéliales de pigment rétinien
WO2015080297A1 (fr) 2013-11-27 2015-06-04 Kyoto Prefectural Public University Corporation Application de laminine à une culture de cellules endothéliales de la cornée
KR102368751B1 (ko) 2014-01-17 2022-03-03 스미또모 가가꾸 가부시끼가이샤 모양체 주연부 간세포의 제조 방법
JP2015195775A (ja) * 2014-04-02 2015-11-09 国立大学法人 東京大学 哺乳動物卵細胞抽出液を用いた無細胞再構築系
WO2015187389A2 (fr) 2014-05-23 2015-12-10 Board Of Trustees Of Michigan State University Procédés et appareil pour réacteurs de dépôt chimique en phase vapeur assisté par plasma micro-onde
RU2718062C2 (ru) 2014-10-31 2020-03-30 Сэндзю Фармасьютикал Ко., Лтд. Новое лечение роговицы с применением ламинина
JP6770435B2 (ja) * 2014-10-31 2020-10-14 京都府公立大学法人 ラミニンによる網膜および神経の新規治療
WO2016161192A1 (fr) 2015-04-03 2016-10-06 Propagenix Inc. Prolifération ex vivo de cellules épithéliales
SG11201801770VA (en) 2015-09-08 2018-04-27 Sumitomo Dainippon Pharma Co Ltd Method for producing retinal pigment epithelial cells
WO2017044454A1 (fr) * 2015-09-11 2017-03-16 Propagenix Inc. Prolifération ex vivo de cellules épithéliales
MY199613A (en) 2016-11-25 2023-11-09 Riken Cell population for transplantation and method for producing same
WO2018164240A1 (fr) 2017-03-08 2018-09-13 大日本住友製薬株式会社 Procédé de production de cellules épithéliales pigmentaires rétiniennes
CA3074426A1 (fr) 2017-09-08 2019-03-14 Sumitomo Dainippon Pharma Co., Ltd. Agregat cellulaire comprenant du tissu retinien, et methode de production correspondante
EP3709990A4 (fr) * 2017-11-17 2021-12-01 The Regents of the University of California Manipulation de la voie de signalisation de l'acide rétinoïque
JP7553924B2 (ja) 2019-04-26 2024-09-19 国立研究開発法人理化学研究所 神経網膜と網膜色素上皮細胞とハイドロゲルとを含む複合体及びその製造方法
JP7760131B2 (ja) 2020-09-11 2025-10-27 株式会社Racthera 移植用組織のための媒体
EP4428227A4 (fr) 2021-11-19 2025-11-12 Riken Procédé de production de tissu rétinien en forme de feuille
US20260000538A1 (en) 2022-01-12 2026-01-01 Riken Tissue transplantation resin tip, tissue transplantation device, retina tissue transplantation method, and retina tissue transplantation kit
EP4477744A4 (fr) * 2022-02-07 2025-06-11 Osaka University Procédé pour induire la différenciation de cellules souches pluripotentes en cellules épithéliales pigmentaires rétiniennes
CN118871141A (zh) 2022-03-16 2024-10-29 住友制药株式会社 移植用介质
EP4659755A1 (fr) 2023-02-14 2025-12-10 RACTHERA Co., Ltd. Médicament thérapeutique pour des déchirures d'épithélium pigmentaire rétinien
JPWO2024204596A1 (fr) 2023-03-29 2024-10-03
CN116445409B (zh) * 2023-06-16 2023-09-22 中国人民解放军总医院第三医学中心 视杆感光前体细胞的制备方法及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009148170A1 (ja) * 2008-06-06 2011-11-04 独立行政法人理化学研究所 幹細胞の培養方法

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WO2012173207A1 (fr) 2012-12-20

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