KR20170063801A - 종양 살상 바이러스 및 이의 사용방법 - Google Patents

종양 살상 바이러스 및 이의 사용방법 Download PDF

Info

Publication number
KR20170063801A
KR20170063801A KR1020177011121A KR20177011121A KR20170063801A KR 20170063801 A KR20170063801 A KR 20170063801A KR 1020177011121 A KR1020177011121 A KR 1020177011121A KR 20177011121 A KR20177011121 A KR 20177011121A KR 20170063801 A KR20170063801 A KR 20170063801A
Authority
KR
South Korea
Prior art keywords
protein
modified
recombinant adenovirus
seq
adsyn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1020177011121A
Other languages
English (en)
Other versions
KR102608590B1 (ko
Inventor
클라대흐 오셔
시게키 미야케-스토너
Original Assignee
더 솔크 인스티튜트 포 바이올로지칼 스터디즈
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 filed Critical 더 솔크 인스티튜트 포 바이올로지칼 스터디즈
Priority to KR1020237040919A priority Critical patent/KR102814615B1/ko
Publication of KR20170063801A publication Critical patent/KR20170063801A/ko
Application granted granted Critical
Publication of KR102608590B1 publication Critical patent/KR102608590B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
    • C12N2810/6018—Adenoviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
    • C12N2810/855—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from receptors; from cell surface antigens; from cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

E2F 비조절 종양 세포에서 선별적으로 복제하는 재조합 아데노바이러스를 개시한다. 상기 재조합 아데노바이러스는 종양세포와 비교하여 정상세포에서 복제결함을 나타내는, 변형된 E1A 단백질, 변형되거나 결실된 E4orf1 단백질, 변형되거나 결실된 E4orf6/7 단백질, 또는 이의 임의의 조합을 암호화하는 게놈을 가지며, 종양세포와 비교하여 정상세포에서 복제결함을 나타낸다. 경우에 따라, 재조합 아데노바이러스 게놈은 재조합 아데노바이러스를 특정 세포 유형으로 표적화하고, 간에서 바이러스를 비표적화시키고, 간에서 바이러스 복제를 억제하고/하거나 이미 존재하는 중화 항체를 회피하는 추가적인 변형을 암호화한다.

Description

종양 살상 바이러스 및 이의 사용방법{ONCOLYTIC TUMOR VIRUSES AND METHODS OF USE}
관련 출원에 대한 상호 참조
본 출원은 그 전문이 본원에 참고로 인용된 2014년 9월 24일자로 출원된 미국 가출원 제62/054,724호의 우선권을 주장한다.
분야
본 발명은 종양세포에서 용균 복제를 선택적으로 겪는 E1A, E4orf1 및/또는 E4orf6/7의 하나 또는 그 이상의 변형을 포함하는 재조합 아데노바이러스에 관한 것이다. 상기 재조합 아데노바이러스는 종양세포에서 전신성 전달 및 흡수를 가능하게 하기 위해 섬유, 헥손 또는 캡시드 단백질에서 선택적으로 하나 또는 그 이상의 변형을 갖는다.
연방 후원 연구 또는 개발에 관한 진술
본 발명은 국립보건원(National Institutes 의 Health)이 수여한 5T32GM007240-35에 따른 정부지원으로 이루어졌다. 정부는 발명에 대해 특정 권리를 가지고 있다.
암은 해마다 50만명 이상의 사망자를 발생시키는, 복잡하고 사람을 쇠약하게 하는 질병이다. 따라서, 보다 효과적이고, 선택적이며, 안전한 암 치료법이 절실히 필요하다. 화학요법 및 수술과 같은 보편적인 생명을 위협하는 질병에 대한 기존 치료법은 모든 악성세포를 거의 제거하지 못하며, 종종 치료효과를 상회할 수 있는 해로운 부작용을 나타낸다.
현재 암 치료법의 단점을 상당 부분 해결할 수 있는 잠재력을 지닌 한 가지 접근법은 종양 살상 아데노바이러스 치료법이다(Pesonen et al., Molecular Pharmaceutics 8(1):12-28, 2010). 아데노바이러스(Ad)는 자체적으로 복제할 수 있는 생물학적 머신이다. 아데노바이러스는 단백질 코트에 쌓인 선형 이중가닥 36kb DNA 게놈으로 구성된다. 아데노바이러스는 세포 복제용 시스템(machinery)을 침범하고 이용하여 번식하고, 조립시, 용균 세포살상을 유도하여 주변세포로 퍼진다. 이와 매우 유사한 세포 조절제는 암의 돌연변이를 표적으로 한다. 이는 유도된 미사일(missile), 특히 종양세포에서 감염 및 복제와 같은 역할을 하는 합성 바이러스를 만들 수 있으며, 가능한 저항을 극복하면서 원격전이를 찾고, 파괴할 수 있는 수천개의 바이러스 자손을 방출하도록 세포를 용해시킨다. 따라서, 종양 살상 바이러스의 설계목표는 암세포에서 특이적으로 복제하는 바이러스를 생성하는 것이지만, 정상세포는 손상시키지 않는다. 그러나 암세포에서 선택적으로 복제할 수 있는 바이러스를 설계하는 데는 상당한 어려움이 있었다. 따라서, 암세포에서 선택적으로 복제하는 추가적인 바이러스에 대한 필요성이 남아있다.
요약
E2F가 탈조절된 종양세포에서 선택적으로 복제하는 재조합 아데노바이러스가 개시된다. 상기 재조합 아데노바이러스는 종양세포와 비교하여 정상세포에서 복제 결함을 나타내며, 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 변형된 또는 결실된 E4orf6/7 단백질, 또는 이의 임의의 조합을 암호화하는 게놈을 갖는다. 상기 재조합 아데노바이러스의 게놈은 선택적으로 추가로 재조합 아데노바이러스를 특정 세포 유형으로 표적화, 간으로부터 바이러스를 비표적화(detarget), 간에서 바이러스 복제를 저해 및/또는 기존의 중화 항체를 회피하는 추가적인 변형을 암호화한다.
본 발명은 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 변형된 또는 결실된 E4orf6/7 단백질, 또는 이들의 임의의 조합을 암호화하는 게놈을 가지며, 종양세포와 비교하여 정상세포에서 복제 결함을 갖는 재조합 아데노바이러스를 제공한다.
일부 실시예에서, 상기 재조합 아데노바이러스 게놈은 유도성 재표적화(retargeting)를 위한 변형을 추가로 암호화한다. 예를 들어, 상기 게놈은 선택적으로 FK506 결합 단백질(FKBP)에 융합된 표적 리간드, 및 야생형 FKBP-라파마이신 결합(FRB) 단백질 또는 T2098L 치환을 포함하는 돌연변이의 FRB 단백질에 융합된 아데노바이러스 섬유 단백질을 암호화한다.
일부 실시예에서, 상기 재조합 아데노바이러스 게놈은 아데노바이러스를 간으로부터 비표적화하는 변형을 추가로 암호화한다. 일부 예에서, 상기 게놈은 헥손 단백질의 변형을 암호화하고 및/또는 간 특이적인 마이크로 RNA를 위한 하나 또는 그 이상의 결합 부위를 포함한다.
일부 실시예에서, 상기 재조합 아데노바이러스 게놈은 바이러스를 다른 세포 수용체로 다시 보내는 키메라 섬유단백질을 암호화한다.
일부 실시예에서, 상기 재조합 아데노바이러스 게놈은 기존의 중화 항체를 회피하기 위해 캡시드가 교환된 아데노바이러스를 암호화한다. 일부 예에서, 상기 게놈의 E1, E3 및 E4 영역은 제1 아데노바이러스 혈청형으로부터 유래되고, 상기 게놈의 E2B, L1, L2, L3, E2A 및 L4 영역은 제2 아데노바이러스 혈청형으로부터 유래된다.
추가로 재조합 리포터 아데노바이러스 유전자 발현 벡터가 제공되며, 여기서 상기 재조합 아데노바이러스의 게놈은 E1의 결실을 포함하고, EF1α 프로모터가 있는 GFP-루시퍼라제 융합 단백질을 암호화한다. 일부 실시예에서, 상기 아데노바이러스 발현 벡터는 3'-UTR에서 간 특이적인 마이크로 RNA 결합 부위를 추가로 포함한다.
또한, 개시된 재조합 아데노바이러스를 포함하는 조성물이 본원발명에서 제공된다. 또한, 재조합 핵산 분자 및 재조합 아데노바이러스 게놈의 서열을 포함하는 벡터가 제공된다.
본 명세서에 개시된 재조합 아데노바이러스(또는 이의 조성물)를 투여함으로써 종양세포의 생존을 저해하고, 종양진행을 저해하며, 종양의 부피를 감소시키고, 암을 가진 개체를 치료하는 방법이 본 개시내용에 의해 추가로 제공된다.
본 명세서의 상기 및 다른 목적 및 특징은 첨부된 도면을 참조하여 진행되는 이하의 상세한 설명으로부터 더욱 명백해질 것이다.
도 1A 및 1B는 재조합 아데노바이러스가 감염된 세포의 아데노바이러스 E1A의 발현을 나타내는 세포 용해물의 면역블롯을 나타낸 도이다. 세포는 AdSyn-CO102(야생형), AdSyn-CO181(E1A ΔLXCXE/ΔE4orf6/7), AdSyn-CO189(E1A ΔLXCXE) 또는 ONYX-838(E1A ΔCR2)으로 감염되지 않거나(mock), 감염되었다. 도 1A에서, 휴지기상태의 인간 초대 소기도 상피세포(SAEC)는 MOI 10에서 감염되었고, 용해물은 E1A 발현에 대해 분석되었다. AdSyn-CO102에 감염된 세포에서, 감염 후기에 E1A 수준이 감소했다. 유사하게, AdSyn-CO189 또는 ONYX-838에 감염된 세포에서, 감염 후기에 E1A 수준이 감소했다; 그러나, 더 이른 시점에서, E1A의 발현은 AdSyn-CO102가 감염된 세포에서의 E1A의 발현보다 더 크다. 반면, AdSyn-CO181에 감염된 세포는 감염을 통해 더욱 강력하고 지속적인 E1A의 발현을 나타냈으며, 이는 아데노바이러스 생활사를 통해 진행하지 못함을 나타낸다. 도 1B에서, 융합성 폐 선암세포(A549)는 MOI 30에서 감염되었고, 용해물은 E1A 발현에 대해 분석되었다. 모든 감염된 세포에서 감염 후기에 E1A 수준이 감소되었고, 이는 전형적인 아데노바이러스 생활사가 진행되었음을 나타낸다.
도 2A 및 2B는 감염된 원발성 종양 및 종양세포에서 세포 사이클린(사이클린) 및 아데노바이러스 후기 단백질의 발현을 나타내는 세포 용해물의 면역블롯을 나타낸 도이다. 세포는 AdSyn-CO102(야생형), AdSyn-CO181(E1A ΔLXCXE/ΔE4orf6/7), AdSyn-CO189(E1A ΔLXCXE), AdSyn-CO210(ΔE4orf6/7), 또는 ONYX-838(E1A ΔCR2)으로 감염되지 않거나(mock), 감염되었다. 도 2A에서, SAEC는 MOI 10에서 감염되었다. 야생형 바이러스 및 E1A 돌연변이만 있는 바이러스와 달리, AdSyn-CO181은 E2F 의존성 세포주기 표적인 S기 사이클린, 사이클린 A 및 사이클린 B를 활성화시키지 못했다. 또한, AdSyn-E4orf6/7 돌연변이를 갖는 AdSyn-CO181 및 AdSyn-CO210은 후기 단백질 발현 및 복제에 결함이 있었다. AdSyn-CO210에서는 상기의 두 가지 결함이 모두 적게 나타났다. 도 2B에서, A549 세포는 MOI 30에서 감염되었다. 감염된 초대 세포와 달리, 후기 구조 단백질의 발현에는 뚜렷한 결함이 없었으며, 사이클린 A 및 사이클린 B는 모든 감염된 A549 샘플에 남아있었다.
도 3A 및 3B는 감염된 SAEC 및 A549 세포에서 각각 세포 DNA를 정량화하는 FACS 히스토그램을 나타낸 도이다. 세포는 AdSyn-CO102(야생형), AdSyn-CO181(E1A ΔLXCXE/ΔE4orf6/7), AdSyn-CO189(E1A ΔLXCXE) 또는 AdSyn-CO210(ΔE4orf6/7)으로 감염되지 않거나(mock), 감염되었으며, 감염 후 48시간에 수거되었다. 감염되지 않은 세포의 DNA 함량은 백그라운드 프로파일에 표시된다. Y축은 세포의 상대적인 수이며, X축은 세포의 프로피디움 요오드화물(PI)에서 나온 형광으로, 이는 DNA의 양에 비례한다. 도 3A에서, 휴지기상태의 SAEC는 MOI 10에서 감염되었다. AdSyn-CO181 감염은 감소된 바이러스 복제와 관련이 있는 AdSyn-CO102에 비해 SAEC에서 강한 DNA 복제결함을 나타냈다. 보통의 결함은 상기 시점에서 AdSyn-CO210에 감염된 SAEC에서도 나타났다. 도 3B에서, A549 세포는 MOI 30에서 감염되었다. 이들 세포에서는 어떠한 돌연변이 바이러스 감염에서도 뚜렷한 DNA 복제결함이 나타나지 않았다.
도 4A 및 4B는 감염된 SAEC 및 A549 세포의 아데노바이러스 버스트(burst)를 각각 나타내는 그래프이다. 세포는 AdSyn-CO102(야생형), AdSyn-CO181(E1A ΔLXCXE/ΔE4orf6/7), AdSyn-CO189(E1A ΔLXCXE), AdSyn-CO210(ΔE4orf6/7) 또는 ONYX-838(E1A ΔCR2)으로 감염되지 않거나(mock), 감염되었으며, 감염 후 48시간 및 72시간에 배지가 수거되었다. 배지내의 감염성 바이러스 입자는 ELISA로 정량화되었다. 도 4A에서, 휴지기상태의 SAEC는 MOI 10에서 감염되었다. AdSyn-CO181 및 AdSyn-CO210 감염 모두 AdSyn-CO102에 비해 SAEC에서 강한 복제결함을 나타냈다. 도 4B에서, A549 세포는 MOI 30에서 감염되었다. AdSyn-CO210을 제외하고는, 이들 세포에서 바이러스의 복제결함이 나타나지 않았다.
도 5A 및 5B는 감염 7일 후, 감염된 SAEC 및 A549 세포의 세포 생존률을 각각 나타낸 그래프이다. 세포는 AdSyn-CO102(야생형), AdSyn-CO181(E1A ΔLXCXE/ΔE4orf6/7), AdSyn-CO189(E1A ΔLXCXE), AdSyn-CO210(ΔE4orf6/7) 또는 ONYX-838(E1A ΔCR2)가 연속희석법으로 감염되지 않거나(mock), 감염되었으며, 세포 대사 활성은 WST-1 분석으로 정량화되었다. 도 5A에서, AdSyn-CO102와 비교하여, AdSyn-CO181은 SAEC에서 세포 살상능력을 감소시켰다. 도 5B에서, 실험한 돌연변이 바이러스는 야생형 바이러스와 비교하여 세포살상에는 결함이 없었다.
도 6A는 세포 용해물의 면역블롯을 나타낸 도이다. MOI 10에서 감염된 정상적인 인간 성상세포(NHA)로 면역블롯을 수행하여 아데노바이러스 후기 구조 단백질 발현 및 세포 사이클린 유도를 검출하였다. AdSyn-CO181은 사이클린 A를 유도하지 않으며, 복제결함을 나타내는 AdSyn-CO102에 비해 감소 및 지연된 후기 바이러스 단백질을 발현한다.
도 6B 및 6C는 NHA에서 AdSyn-CO181이 약독화된 감염을 나타내는 그래프이다. 도 6B에서, NHA는 바이러스 패널(panel)에 의해 감염되었으며, 배지내 감염 입자의 수는 감염 후 48시간 및 72시간에 정량화되었다. AdSyn-CO181 및 AdSyn-CO189는 NHA에서 AdSyn-CO102에 비해 복제결함을 보였다. 도 6C에서, DNA 복제는 감염 48시간 후 MOI 10에서 감염된 NHA에서 PI FACS에 의해 정량화되었다. 감염되지 않은 세포의 DNA 함량은 히스토그램의 백그라운드 프로파일에 표시된다. Y축은 세포의 상대적인 수이며, X축은 핵산의 양에 비례하는 세포내 PI에서 나온 형광이다. AdSyn-CO181은 감소된 바이러스 복제와 관련이 있는 AdSyn-CO102와 비교하여 DNA 복제의 유도를 감소시켰다.
도 7A는 감염된 교모세포종 U87 세포로부터 얻은 세포 용해물의 면역블롯을 나타낸 도이다. MOI 20에서 감염된 U87 세포로 면역블롯을 수행하여 아데노바이러스 후기 구조 단백질 발현 및 세포 사이클린 유도를 검출하였다.
도 7B 및 7C는 교모세포종 U87 세포에서 복제결함이 없는 재조합 아데노바이러스를 나타내는 그래프이다. 도 7B에서, U87 세포는 바이러스 패널(panel)에 의해 감염되었으며, 배지내 감염 입자의 수는 감염 후 48시간 및 72시간에 정량화되었다. 도 7C에서, DNA 복제는 감염 48시간 후 MOI 20에서 감염된 U87 세포에서 PI FACS에 의해 정량화되었다. 감염되지 않은 세포의 DNA 함량은 히스토그램의 백그라운드 프로파일에 표시된다. Y축은 세포의 상대적인 수이며, X축은 핵산의 양에 비례하는 세포내 PI에서 나온 형광이다.
도 8A는 감염된 교모세포종 U118 세포로부터 얻은 세포 용해물의 면역블롯을 나타낸 도이다. MOI 20에서 감염된 U118 세포로 면역블롯을 수행하여 아데노바이러스 후기 구조 단백질 발현 및 세포 사이클린 유도를 검출하였다.
도 8B 및 8C는 교모세포종 U118 세포에서 복제결함이 없는 재조합 아데노바이러스를 나타내는 그래프이다. 도 8B에서, U118 세포는 바이러스 패널(panel)에 의해 감염되었으며, 배지내 감염 입자의 수는 감염 후 48시간 및 72시간에 정량화되었다. 도 8C에서, DNA 복제는 감염 48시간 후 MOI 20에서 감염된 U118 세포에서 PI FACS에 의해 정량화되었다. 감염되지 않은 세포의 DNA 함량은 히스토그램의 백그라운드 프로파일에 표시된다. Y축은 세포의 상대적인 수이며, X축은 핵산의 양에 비례하는 세포내 PI에서 나온 형광이다.
도 9A는 감염된 인간 섬유아세포(IMR90 세포)로부터 얻은 세포 용해물의 면역블롯을 나타낸 도이다. MOI 10에서 감염된 섬유아세포로 면역블롯을 수행하여 후기 구조 단백질 발현을 검출하였다. AdSyn-CO181은 복제결함을 나타내는 AdSyn-CO102에 비해 감소 및 지연된 후기 바이러스 단백질을 발현한다.
도 9B 및 9C는 AdSyn-CO181이 IMR90 세포에서 보통의 복제 결함을 갖는 것을 보여주는 그래프이다. 도 9B에서, 섬유아세포는 바이러스 패널(panel)에 의해 감염되었으며, 배지내 감염 입자의 수는 감염 후 48시간 및 72시간에 정량화되었다. 상기 시점에서 상기 분석법을 사용한 결과, 변형된 아데노바이러스의 복제 능력에는 명확한 차이가 없었다. 도 9C에서, DNA 복제는 감염 48시간 후 MOI 20에서 감염된 섬유세포에서 PI FACS에 의해 정량화되었다. 감염되지 않은 세포의 DNA 함량은 히스토그램의 백그라운드 프로파일에 표시된다. Y축은 세포의 상대적인 수이며, X축은 핵산의 양에 비례하는 세포내 PI에서 나온 형광이다. AdSyn-CO181은 감소된 바이러스 복제와 관련이 있는 AdSyn-CO102와 비교하여 DNA 복제의 유도를 감소시켰다.
도 10은 감염된 1차 NHA 세포의 감염 10일 후 세포 생존능을 나타내는 그래프이다. 세포는 야생형 또는 돌연변이 바이러스가 연속희석법으로 감염되었다. 대사 활성은 WST-1 분석에 의해 정량화되었다. 세포 당 3 내지 10개의 감염성 입자에서 두 그룹의 바이러스가 뚜렷하게 나타났으며, 그래프에서 "더 적은 살상(less killing)"과 "더 많은 살상(more killilng)"으로 분류되었다. 더 적은 세포 살상을 유도한 바이러스는 Rb 결합 돌연변이 및 E4orf6/7의 결실이 있는 E1A를 가진다. 더 많은 살상을 유도한 바이러스는 야생형 E1 또는 야생형 E4를 가진다.
도 11은 감염된 휴지기상태 SAEC-hTERT 세포의 감염 9일 후 세포 생존능을 나타내는 그래프이다. 세포는 야생형 또는 돌연변이 바이러스가 연속희석법으로 감염되었다. 대사 활성은 WST-1 분석에 의해 정량화되었다. 세포 당 3 내지 10개의 감염성 입자에서 두 그룹의 바이러스가 뚜렷하게 나타났으며, 그래프에서 "더 적은 살상(less killing)"과 "더 많은 살상(more killilng)"으로 분류되었다. 더 적은 세포 살상을 유도한 바이러스는 Rb 결합 돌연변이 및 E4orf6/7의 결실이 있는 E1A를 가진다. 더 많은 살상을 유도한 바이러스는 야생형 E1 또는 야생형 E4를 가진다.
도 12는 감염된 증식하는 SAEC-hTERT 세포의 감염 9일 후 세포 생존능을 나타내는 그래프이다. 세포는 야생형 또는 돌연변이 바이러스가 연속희석법으로 감염되었다. 대사 활성은 WST-1 분석에 의해 정량화되었다. 세포 당 3 내지 10개의 감염성 입자에서 두 그룹의 바이러스가 뚜렷하게 나타났으며, 그래프에서 "더 적은 살상(less killing)"과 "더 많은 살상(more killilng)"으로 분류되었다. 더 적은 세포 살상을 유도한 바이러스는 Rb 결합 돌연변이 및 E4orf6/7의 결실이 있는 E1A를 가진다. 더 많은 살상을 유도한 바이러스는 야생형 E1 또는 야생형 E4를 가진다.
도 13은 감염된 A549 세포의 감염 7일 후 세포 생존능을 나타내는 그래프이다. 세포는 야생형 또는 돌연변이 바이러스가 연속희석법으로 감염되었다. 대사 활성은 WST-1 분석에 의해 정량화되었다.
도 14는 감염된 사람 유방암세포(MDA MB 231)의 감염 7일 후 세포 생존능을 나타내는 그래프이다. 세포는 야생형 또는 돌연변이 바이러스가 연속희석법으로 감염되었다. 대사 활성은 WST-1 분석에 의해 정량화되었다.
도 15는 감염된 교모세포종 세포(U87)의 감염 7일 후 세포 생존능을 나타내는 그래프이다. 세포는 야생형 또는 돌연변이 바이러스가 연속희석법으로 감염되었다. 대사 활성은 WST-1 분석에 의해 정량화되었다.
도 16은 도 10 내지 15에 나타낸 감염된 1차 NHA, SAEC-hTERT(휴지기상태), SAEC-hTERT(증식하는), A549, MDA MB 231 및 U87 세포에 대한 세포 생존능을 정량화한 표이다.
도 17은 감염된 U2OS 세포(기능적인 p53 및 Rb를 가짐) 및 SaOS2 세포(비기능적인 p53 및 Rb를 가짐)에 대한 세포 생존능을 정량화한 표이다. 세포는 야생형 또는 돌연변이 바이러스가 연속희석법으로 감염되었다. 대사 활성은 WST-1 분석에 의해 정량화되었다.
도 18A는 FRB 도메인과 라파마이신 및 FKBP12와의 결합 경계면를 나타내는 도이다. 돌연변이된 FRB 도메인(FRB*; mTOR 잔기 T2098L)은 라파마이신 또는 라파마이신 동족체(homolog) AP21967과 FRB/FKBP12 헤테로다이머를 형성하도록 유도된다. 도 18B는 FRB-섬유(AdSyn-CO205; 서열번호 88)를 갖는 EGFR-표적화 바이러스가 라파마이신의 존재하에서 MDA MB 453 유방암세포의 향상된 전달을 가졌지만 AP21967은 그렇지 않음을 보여주는 그래프이다. FRB*-섬유(AdSyn-CO220; 서열번호 98)를 갖는 EGFR-표적화 바이러스는 라파마이신 또는 AP21967의 존재하에서 MDA MB453 세포의 형질도입이 향상되었다. 도 18C는 표적인 p70 S6K의 인산화를 차단하는 mTOR 저해제 라파마이신의 활성을 나타내는 면역블롯이다. 라파마이신 동족체 AP21967은 표적화 농도에서 mTOR를 저해하지 않는다. 도 18D는 감염된 전이성 유방암세포 HS578T의 감염 9일 후 세포 생존능을 나타내는 그래프이다. 세포는 AdSyn-CO312가 연속희석법으로 감염되었다. 감염 후 24, 48, 72 및 96시간에 50nM의 신선한 라파마이신 또는 AP21967이 첨가되었다. 대사 활성은 WST-1 분석에 의해 정량화되었고, 일치하는 약물 치료법으로 감염되지 않은 세포에 대해 정상화되었다. AdSyn-CO312는 E1A ΔLXCXE, ΔE4orf6/7, ΔE3-RIDα/β, ΔE3-14.7k의 종양 살상 돌연변이를 가지며, 라파마이신-또는 AP21967-의존성 EGFR-표적화 유전자 EGFRVHH-FKBP 및 FRB*-섬유를 발현한다. 라파마이신 또는 AP21967이 처리된 EGFR- 표적화된 종양 살상 바이러스에 감염된 세포는 표적화되지 않은 경우에 비해 살상이 강화되었다. 도 18E는 감염된 전이성 유방암세포 HS578T의 감염 9일 후 세포 생존능을 나타내는 그래프이다. 세포는 연속적으로 희석된 AdSyn-CO313dl로 감염되었다. 감염 후, 24, 48, 72 및 96시간에 50nM의 신선한 라파마이신 또는 AP21967이 첨가되었다. 대사 활성은 WST-1 분석에 의해 정량화되었고, 일치하는 약물 치료법으로 감염되지 않은 세포에 대해 정상화되었다. AdSyn-CO313은 E1A ΔLXCXE, ΔE4orf6/7, ΔE3-RIDα/β, ΔE3-14.7k의 종양 살상 돌연변이를 가지며, 라파마이신-의존성 EGFR-표적화 유전자 EGFRVHH-FKBP 및 FRB-섬유를 발현한다. 라파마이신이 처리된 EGFR-표적화 종양 살상 바이러스에 감염된 세포는 표적화되지 않은 경우에 비해 살상이 강화되었다.
도 19는 HS578T를 피하 이종 이식한 마우스에서 평균적인 종양의 부피를 나타내는 그래프이다. 종양이 생긴 마우스의 종양내로 AdSyn-CO313가 주사된 후, 주기적으로 복강내에 8 mg/kg의 라파마이신(n = 5) 또는 비히클(vehicle) 대조군(n = 4)이 주사되거나 비히클 대조군이 종양내로 주사된 후, 주기적으로 복강내에 8 mg/kg의 라파마이신(n = 5) 또는 비히클 대조군(n = 4)이 주사되었다. 감염은 초기 감염 후 19일부터 4일 간격으로 같은 그룹에서 3번 이상 반복하여 감염되었다. AdSyn-CO313은 E1A ΔLXCXE, ΔE4orf6/7, ΔE3-RIDα/β 및 ΔE3-14.7k의 종양 살상 돌연변이를 가지며, 라파마이신-의존성 EGFR-표적화 유전자 EGFRVHH-FKBP 및 FRB-섬유를 발현한다. EGFR-표적화 종양 살상 바이러스를 라파마이신과 함께 투여한 마우스에서 종양은 최상의 반응을 나타냈다.
도 20은 감염된 전이성 유방암세포 HS578T의 감염 9일 후 세포 생존능을 나타내는 그래프이다. 세포는 연속적으로 희석된 AdSyn-CO335로 감염되었다. 감염 후, 24, 48, 72 및 96시간에 50nM의 신선한 라파마이신 또는 AP21967이 첨가되었다. 대사 활성은 WST-1 분석에 의해 정량화되었고, 일치하는 약물 치료법으로 감염되지 않은 세포에 대해 정상화되었다. AdSyn-CO335는 E1A ΔLXCXE, ΔE4orf6/7, ΔE3-RIDα/β 및 ΔE3-14.7k의 종양 살상 돌연변이를 가지며; 간을 표적화하지 않는 E451Q 헥손 변형을 가지며; 라파마이신- 또는 AP21967-의존성 EGFR-표적화 유전자 EGFRVHH-FKBP 및 FRB*-섬유를 발현한다. 라파마이신 또는 AP21967이 처리된 EGFR-표적화 종양 살상 바이러스에 감염된 세포는 표적화되지 않은 경우에 비해 살상이 강화되었다.
도 21A 및 21B는 HS578T를 피하 이종 이식한 마우스에서 평균적인 종양의 부피를 나타내는 그래프이다. 도 21C 및 21D는 HS578T를 피하 이종 이식한 마우스에서 종양 부피의 변화를 배수 값으로 나타낸 그래프이다. 종양이 생긴 마우스의 종양내로 Syn-CO335가 4일마다 세 차례씩 주사된 후, 다음날부터 격일로 복강내에 2 또는 8 mg/kg의 라파마이신(각각 n = 8 및 n = 8), 또는 비히클(vehicle) 대조군(n = 6)이 주사되거나; 종양이 생긴 마우스의 종양내로 AdSyn-CO442가 4일마다 세 차례씩 주사된 후, 다음날부터 격일로 복강내에 2 또는 8 mg/kg의 라파마이신(각각 n = 6 및 n = 6)이 주사되거나; 종양이 생긴 마우스의 종양내로 비히클 대조군이 4일마다 세 차례씩 주사된 후, 다음날부터 격일로 복강내에 2 또는 8 mg/kg의 라파마이신(각각 n = 6 및 n = 6)이 주사되었다. EGFR-표적화 종양 살상 바이러스를 8 mg/kg의 라파마이신과 함께 투여한 마우스에서 종양은 최상의 반응을 나타냈다.
도 22A 내지 22C는 간에서 아데노바이러스가 매개된 유전자 발현의 제거 및 간으로의 아데노바이러스 감염의 비표적화(detargeting)를 나타내는 사진이다. 도 22A에 나타낸 바와 같이, E1 영역이 결여된 아데노바이러스 벡터인 AdSyn-CO199는 전신성 감염 후 간에서 독점적으로 루시퍼라제를 높은 수준으로 발현한다. 도 22B에 나타낸 바와 같이, 간 특이적인 microRNA miR122가 루시퍼라제 발현을 제거한다는 것을 제외하고는 AdSyn-CO199와 일치하는 AdSyn-CO200가 마우스 전신에 감염되면 루시퍼라제 신호가 사라진다. 도 22C에 나타낸 바와 같이, 간으로부터 비표적화하는 아데노바이러스 헥손 단백질이 돌연변이 E451Q를 가지는 것을 제외하고는 AdSyn-CO200과 일치하는 AdSyn-CO171이 마우스 전신에 감염되면 루시퍼라제의 발현은 비장에서 검출될 수 있다.
도 23A 내지 23E는 섬유 단백질 구조의 모식도 및 다양한 세포 유형을 더 잘 변환하는 키메라 섬유 단백질로 바이러스를 생성하기 위한 두 가지 아데노바이러스 혈청형으로부터의 모듈을 조합하여 생성된 재조합 아데노바이러스를 특징으로 하는 일련의 그래프 및 이미지를 나타내는 도이다.
도 24A는 캡시드가 교환된 키메라 바이러스를 생성하기 위한 모듈변경을 나타내는 도이다. 도 24B는 특정 돌연변이 바이러스 및 바이러스의 E1, 코어(core), E3 및 E4 모듈 변경사항을 나열한 표이다.
도 25A 내지 25E는 캡시드가 교환된 바이러스로부터 단백질 함량 및 발현을 나타내는 일련의 면역블롯을 나타낸 도이다.
도 26A 내지 26C는 캡시드가 교환된 바이러스가 항-Ad5 항체를 함유하는 인간 혈청에 의해 중화되지 않음을 보여주는 일련의 그래프이다.
도 27은 종 A(Ad12; 서열번호 47), 종 B(Ad7; 서열번호 48), 종 C(Ad2 및 Ad5; 각각 서열번호 49 및 서열번호 50), 종 D(Ad9; 서열번호 51), 종 E(Ad4; 서열 번호 52), 종 F(Ad40; 서열 번호 53) 및 종 G(Ad52; 서열 번호 54)를 포함하는 인간 아데노바이러스 종으로부터의 E1A 서열을 정렬한 도이다. 본 명세서에 개시된 종양 살상 아데노바이러스 조성물에서 발견되는 돌연변이 부위인 Y47이 개략적으로 설명된다. 회색 상자로 강조 표시된 것은 강력한 E1A-Rb 상호작용에 필요한 C124가 포함된 LXCXE 모티프이다.
도 28은 종 A(Ad12; 서열번호 55), 종 B(Ad7; 서열번호 56), 종 C(Ad2 및 Ad5; 각각 서열번호 57 및 서열번호 58), 종 D(Ad9; 서열번호 59), 종 E(Ad4; 서열번호 60) 및 종 G(Ad52; 서열번호 61)를 포함하는 인간 아데노바이러스 종으로부터의 E4orf1 서열을 정렬한 도이다. 회색 상자로 강조 표시된 것은 E4orf1이 PI3K를 상향 조절하고 세포 증식의 음성 조절을 방지하는 PDZ 결합 모티프이다.
도 29는 라파마이신-의존성 EGFR-표적화 성분을 갖는 합성 아데노바이러스로 감염된 293-E4 세포로부터의 단백질 발현의 면역블롯을 나타내는 도이다. 293-E4 세포는 Adsembly 야생형 Ad(AdSyn-CO170), 표적화-변형된 AdSyn-CO205, 또는 대조군 바이러스인 AdSyn-CO206 또는 AdSyn-CO207에 의해 MOI 10으로 감염되었다. 라파마이신-조절된 EGFR-표적화 바이러스 AdSyn-CO205를 위해, GFP 리포터는 감염의 표지자로서 E1A에 융합되었다. E3B 전사체는 RIDα, RIDβ, 및 14.7k를 제거함으로써 변형되었으며, EGFRVHH-FKBP를 발현하는데 사용되었다. AdSyn-CO206은 AdSyn-CO205의 모든 변형을 포함하지만, 야생형 섬유를 유지하므로 FRB 도메인을 갖지 않는다. AdSyn-CO207은 AdSyn-CO206의 모든 변형을 가지고 있지만, 야생형 E3 영역을 유지하므로 FKBP-융합 유전자를 갖지 않는다. 섬유의 이동에서 변화는 AdSyn-CO207 및 AdSyn-CO205에서 90개의 아미노산 FRB 도메인의 삽입을 보여준다. EGFRVHH-FKBP 융합 단백질의 발현은 FKBP12에 대해 조사함으로써 검출되었다. 후기 단백질 발현의 시간 경과에 따라, 캡시드-돌연변이, 또는 GFP-E1A 리포터를 가진 EGFRVHH-FKBP 발현 바이러스의 복제에 있어서 명백한 결함이 Adsembly 야생형 Ad와 비교하여 나타나지 않았다.
도 30은 비히클(비감염), 대조군 바이러스(AdSyn-CO442), 또는 종양 살상 아데노바이러스(AdSyn-CO335)의 종양내 3회 주사 및 3주간 격일로 라파마이신(0, 2 또는 8 mg/kg)의 종양내 공투여 후, 28일째의 HS578T 이종 이식편 종양반응을 나타낸 워터폴(waterfall) 플롯을 나타낸 도이다. 왼쪽에서 오른쪽으로 (a) 감염되지 않았고, 라파마이신이 투여되지 않음; (b) 감염되지 않았고, 2 mg/kg의 라파마이신이 투여됨; (c) 감염되지 않았고, 8 mg/kg의 라파마이신이 투여됨; (d) AdSyn-CO335가 감염되었고, 라파마이신이 투여되지 않음; (e) AdSyn-CO335가 감염되었고, 2 mg/kg의 라파마이신이 투여됨; (f) AdSyn-CO335가 감염되었고, 8 mg/kg의 라파마이신이 투여됨; (g) AdSyn-CO442가 감염되었고, 2 mg/kg의 라파마이신이 투여됨; 및 (h) AdSyn-CO442가 감염되었고, 8 mg/kg의 라파마이신이 투여됨. N = 각 그룹에서 종양의 수. 각각의 열은 하나의 개별 종양을 나타내며, 치료 전 종양 부피와 관련하여 데이터가 표시된다.
도 31은 HS578T 이종 이식 조직의 면역조직화학염색(IHC)을 나타내는 도이다. HS578T를 피하 이종 이식한 마우스는 복강내에 100 ㎕의 비히클, 2 mg/kg의 라파마이신 또는 8 mg/kg의 라파마이신이 주사됨으로써 치료되었다. 주사하고 1시간 후, 이종 이식 조직을 수득하여 10% 포르말린에 고정시키고, P70S6K의 포스포-T378 형태를 인식하는 항체로 IHC 염색을 위해 절편화했다. 트레오닌 389(P70S6K p-T389)에서 인산화된 P70S6K에 대해 염색된 HS578T 이종 이식편 조직 절편의 마이크로픽토그래프가 나타나있다. T389에서 P70S6K의 인산화는 mTOR 활성의 특징이다. 치료가 되지 않은 조직 또는 낮은 아데노바이러스 EGFR-표적화 유효량(2 mg/kg)에서, mTOR 활성은 P70S6K p-T389의 염색에 의해 입증된 바와 같이 저해되지 않는다. 보다 높은 아데노바이러스 EGFR-표적화 유효량(8 mg/kg)에서, mTOR 활성은 저해되고, P70S6K p-T389 염색의 소실로 표시된다.
서열목록
수반되는 서열목록에 열거된 핵산 및 아미노산 서열은 뉴클레오티드 염기에 대한 표준 문자 약어 및 37 C.F.R. 1.822에 정의된 아미노산에 대한 3문자 코드를 사용하여 나타냈다. 핵산 서열 각각의 한 가닥만을 나타내지만, 상보적인 가닥은 표시된 가닥에 대한 임의의 언급에 의해 포함되는 것으로 이해된다. 서열목록은 2015년 9월 23일, 2.91 MB에 작성된 ASCⅡ 텍스트 파일로 제출되며, 상기 파일은 여기에 참조로 포함된다. 수반되는 서열목록은 하기와 같다:
서열번호 1 내지 31 및 68 내지 98은 재조합 아데노바이러스의 뉴클레오티드 서열이다(표 1 내지 5; 실시예 6; 및 실시예 7 참조).
서열번호 32는 Ad5 E1A의 아미노산 서열이다.
서열번호 33은 Ad5 E1A ΔLXCXE의 아미노산 서열이다.
서열번호 34는 Ad5 E1A C124G의 아미노산 서열이다.
서열번호 35는 Ad5 E1A Δ2-11의 아미노산 서열이다.
서열번호 36은 Ad5 E1A Y47H C124G의 아미노산 서열이다.
서열번호 37은 Ad5 E1A Δ2-11 Y47H C124G의 아미노산 서열이다.
서열번호 38은 Ad5 E4orf1의 아미노산 서열이다.
서열번호 39는 Ad5 E4orf1ΔPDZb의 아미노산 서열이다.
서열번호 40은 Ad5 E4orf6/7의 아미노산 서열이다.
서열번호 41은 Ad5 섬유의 아미노산 서열이다.
서열번호 42는 Ad5 FRB-섬유의 아미노산 서열이다.
서열번호 43은 Ad5 FRB*-섬유의 아미노산 서열이다.
서열번호 44는 EGFRVHH-GS-FKBP의 아미노산 서열이다.
서열번호 45는 Ad5 헥손의 아미노산 서열이다.
서열번호 46은 Ad5 헥손 E451Q의 아미노산 서열이다.
서열번호 47은 종 A (Ad12) E1A의 아미노산 서열이다.
서열번호 48은 종 B (Ad7) E1A의 아미노산 서열이다.
서열번호 49는 종 C (Ad2) E1A의 아미노산 서열이다.
서열번호 50은 종 C (Ad5) E1A의 아미노산 서열이다.
서열번호 51은 종 D (Ad9) E1A의 아미노산 서열이다.
서열번호 52는 종 E (Ad4) E1A의 아미노산 서열이다.
서열번호 53은 종 F (Ad40) E1A의 아미노산 서열이다.
서열번호 54는 종 G (Ad52) E1A의 아미노산 서열이다.
서열번호 55는 종 A (Ad12) E4orf1의 아미노산 서열이다.
서열번호 56은 종 B (Ad7) E4orf1의 아미노산 서열이다.
서열번호 57은 종 C (Ad2) E4orf1의 아미노산 서열이다.
서열번호 58은 종 C (Ad5) E4orf1의 아미노산 서열이다.
서열번호 59는 종 D (Ad9) E4orf1의 아미노산 서열이다.
서열번호 60은 종 E (Ad4) E4orf1의 아미노산 서열이다.
서열번호 61은 종 G (Ad52) E4orf1의 아미노산 서열이다.
서열번호 62는 Ad2의 뉴클레오티드 서열이다.
서열번호 63은 Ad5의 뉴클레오티드 서열이다.
서열번호 64는 Ad2 E4orf6/7의 아미노산 서열이다.
서열번호 65는 Ad5 E3-RIDα의 아미노산 서열이다.
서열번호 66은 Ad5 E3-RIDβ의 아미노산 서열이다.
서열번호 67은 Ad5 E3-14.7K의 아미노산 서열이다.
Ⅰ. 약어
Ad 아데노바이러스
CAR 콕사키(coxsackie) 아데노바이러스 수용체
CPE 세포변성 효과
EGFR 표피성장인자수용체
ELISA 효소면역측정법
FACS 형광표지세포분류
FKBP FK 506 결합 단백질
FRB FKBP-라파마이신 결합
hTERT 인간 텔로머라아제 역전사 효소
HuVEC 인간 혈관 내피세포
MAV-1 마우스 아데노바이러스 1
miR 마이크로 RNA
MOI 감염다중도
mTOR 라파마이신의 포유류 표적
NHA 정상적인 인간 성상세포
PET 양전자방출단층촬영
PI 프로피디움 요오드화물
PRP PET 리포터 프로브
Rb 망막아세포종(retinoblastoma)
SAEC 소기도 상피세포
WT 야생형
Ⅱ. 용어 및 방법
달리 명시하지 않는 한, 기술적인 용어는 통상적인 사용법에 따라 사용된다. 분자 생물학에서 일반적인 용어의 정의는 Benja분 Lewin, Genes V, published by Oxford University Press, 1994(ISBN 0-19-854287-9); Kendrew et al.(eds.), Encyclopedia 의 Molecular Biology, published by Blackwell Science Ltd., 1994(ISBN 0-632-02182-9); 및 Robert A. Meyers(ed.), Molecular Biology and Biotechnology: a Comprehensive Desk Reference, published by VCH Publishers, Inc., 1995(ISBN 1-56081-569-8)에 기재되어있다.
본 명세서에 개시된 다양한 실시예들의 검토를 용이하게 하기 위해, 특정 용어에 대한 하기의 설명이 제공된다 :
아데노바이러스: 라이너(liner), 이중가닥 DNA 게놈 및 정이십면체 캡시드를 갖는 비 외피성(non-enveloped) 바이러스이다. 현재 7종(종 A, B, C, D, E, F 및 G)으로 분류된 68종의 인간 아데노바이러스 혈청형이 있다. 아데노바이러스의 다른 혈청형은 호흡기 질환(주로 종 B 및 C), 결막염(종 B 및 D) 및/또는 위장염(종 F 및 G)을 유발하는 여러 유형의 질병과 관련된다.
투여: 임의의 효과적인 경로에 의해 치료제(예를 들어, 재조합 바이러스)와 같은 제제를 개체에게 제공하기 위함이다. 예시적인 투여 경로는 주사(피하, 근육내, 피내, 복강내 및 정맥내), 경구, 관내, 설하, 직장, 경피, 비강내, 질 및 흡입경로를 포함하지만 이에 한정되지 않는다.
항체: 항원의 에피토프(epitope)를 인식하고 결합(예를 들어, 특이적으로 인식하고 특이적으로 결합)하는 경쇄 및/또는 중쇄 면역글로불린 가변영역을 적어도 포함하는 폴리펩티드 리간드이다. 면역글로불린 분자는 중쇄 및 경쇄로 구성되며, 각각은 중쇄 가변영역(VH) 및 경쇄 가변영역(VL)으로 불리는 가변영역을 갖는다. VH 영역 및 VL 영역은 함께 항체에 의해 인식되는 항원을 결합시키는 역할을 한다.
항체는 손상되지 않은 면역글로불린 및 단일 도메인 항체(예를 들어, VH 도메인 항체 또는 VHH 항체), Fab 단편, Fab' 단편, F(ab)'2 단편, 단일 가닥의 Fv 단백질("scFv"), 및 이황화물 안정화된 Fv 단백질("dsFv")와 같은 당업계에서 잘 알려진 항체의 변이체 및 부분(단편)을 포함한다. scFv 단백질은 면역글로불린의 경쇄 가변영역과 면역글로불린의 중쇄 가변영역이 링커에 의해 결합된 융합 단백질이며, dsFv에서는 가닥이 돌연변이 되어 이황화 결합을 도입하여 가닥의 결합을 안정화시킨다. 용어 "항체"는 또한 키메라 항체(예를 들어, 인간화된 쥐 항체) 및 이종접합 항체(예를 들어, 이중 특이성 항체)와 같은 유전적으로 조작된 형태를 포함한다. 또한, Pierce Catalog and Handbook, 1994-1995(Pierce Chemical Co., Rockford, IL); Kuby, J., Immunology, 3rd Ed., W.H. Freeman & Co., New York, 1997을 참조한다.
화학치료제: 비정상적인 세포성장에 의해 특징화되는 질병의 치료에서 치료적 유용성을 가지는 화학 작용제이다. 상기 질병은 종양, 신생물 및 암뿐만 아니라 건선과 같은 과증식 성장에 의해 특징화되는 질병을 포함한다. 일 실시예에서, 화학치료제는 방사성 화합물이다. 당업계에서 기술자는 사용하는 화학치료제(예를 들어, Slapak and Kufe, Principles 의 Cancer Therapy, Chapter 86 in Harrison's Principles 의 Internal Medicine, 14th edition; Perry et al., Chemotherapy, Ch. 17 in Abeloff, Clinical Oncology 2nd ed., ⓒ 2000 Churchill Livingstone, Inc; Baltzer, L., Berkery, R.(eds.): Oncology Pocket Guide to Chemotherapy, 2nd ed. St. Louis, Mosby-Year Book, 1995; Fischer, D.S., Knobf, M.F., Durivage, H.J.(eds): Cancer Chemotherapy Handbook, 4th ed. St. Louis, Mosby-Year Book, 1993 참조)를 쉽게 확인할 수 있다. 병용화학요법은 암 치료를 위한 하나 이상의 제제를 투여하는 것이다.
키메라: 적어도 기원이 다른 두 부분으로 구성된다. 본 명세서에 개시된 "키 메라 아데노바이러스"는 적어도 두 개의 상이한 혈청형(예를 들어, Ad5 및 아데노바이러스의 제2 혈청형)으로부터 유래된 유전물질 및/또는 단백질을 갖는 아데노바이러스이다. 이러한 맥락에서, "캡시드 교환된" 아데노바이러스는 캡시드 단백질이 하나의 혈청형 아데노바이러스로부터 유래되고 나머지 단백질이 다른 아데노바이러스 혈청형으로부터 유래된 키메라 아데노바이러스를 의미한다. 유사하게, "키메라 섬유"는 아데노바이러스의 적어도 두 개의 상이한 혈청형으로부터 유래된 아미노산 서열을 갖는 섬유 단백질이다. 예를 들어, 키메라 섬유는 Ad5로부터의 섬유 샤프트 및 아데노바이러스의 제2 혈청형으로부터의 섬유 노브로 구성될 수 있다(도 23A 참조).
접촉시키는: 직접적인 물리적 연관에서의 배치이다; 고체 및 액체 형태 모두를 포함한다.
퇴행 변이체: 본 명세서에 개시된 "퇴행 변이체"는 유전암호의 결과로서 퇴행된 서열을 포함하는 펩티드를 암호화하는 폴리뉴클레오티드를 의미한다. 20개의 천연 아미노산이 있으며, 대부분은 하나 이상의 코돈에 의해 특정된다. 따라서, 뉴클레오티드 서열에 의해 암호화되는 펩티드의 아미노산 서열이 변하지 않는 한, 펩티드를 암호화하는 모든 퇴행 뉴클레오티드 서열이 포함된다.
결실된: "결실된" E4orf1 또는 E4orf6/7 단백질을 암호화하는 아데노바이러스 게놈은 E4orf1 또는 E4orf6/7 코딩서열의 완전한 결실, 또는 E4orf1 또는 E4orf6/7 단백질의 부재로 인한 부분적인 결실을 갖는 아데노바이러스를 의미한다.
E2F의 비조절: 거의 모든 유형의 인간 암에서 발생하는 E2F 전사인자 및 하류 표적 유전자의 활성 증가를 의미한다. E2F 경로 활성 및 전사의 비조절은 Rb, p107 및 p130 종양 억제인자의 기능 상실 돌연변이 및 결실과 같은 경로의 임의의 상류 구성요소에서 다양한 다른 돌연변이로 인해 발생할 수 있다. Rb는 확인된 최초의 종양 억제인자였고, 적어도 인간 종양의 1/3에서 결함되거나 돌연변이가 발생했다. 또한, p16 돌연변이 및/또는 후생학적 사일런싱(silencing)은 종양세포에서 E2F를 활성화시킬 수 있다. 사이클린 D 및 CDK4 돌연변이, 유전자 증폭 또는 과발현은 또한 인간 종양에서 조절되지 않은 E2F 활성을 초래할 수 있다. 또한, E2F는 EGFR, RTK, RAS, RAF, PI-3K, PTEN, RAF, MYC 등을 포함하는 성장인자 수용체 경로 돌연변이에 의해 활성화된다. p16INK4a-사이클린 D:cdk4/6-RB-E2F 경로에서 돌연변이는 일반적으로 상호 배타적인 방식으로 발생하기 때문에 하나의 '히트(hit)'(예를 들어, p16)는 다른 것들에 의해 동반되지 않는다(예를 들어, Rb 돌연변이 또는 사이클린 D:cdk 과발현). 그러나 현재 대부분의 화학요법은 E2F 전사 표적을 저해하는 증식성 독극물이지만, 정상세포에도 독성을 지니고 있으며 종종 파괴적인 의인성 합병증을 일으킨다. 본 명세서에 개시된 바와 같이, 대안적인 치료 방법은 조절되지 않은 p16-사이클린 D:cdk4-RB-E2F 경로를 가진 암세포 병변에서 선택적인 용균 복제를 수행하는 바이러스를 사용하는 것이다.
E1A: 아데노바이러스 초기 영역 1A(E1A) 유전자 및 유전자로부터 발현된 폴리펩티드이다. E1A 단백질은 세포를 세포주기로 유도하여 바이러스 게놈 복제에 중요한 역할을 한다. 본 명세서에서 개시된 용어 "E1A 단백질"은 E1A 유전자로부터 발현된 단백질을 의미하며 용어는 임의의 아데노바이러스 혈청형에 의해 생성된 E1A 단백질을 포함한다. 일례로, 야생형 Ad5 E1A 단백질의 아미노산 서열은 서열번호 32로 기재되며, 변형된 Ad5 E1A 서열은 서열번호 33 내지 37로 본 명세서에서 제공된다. 또한, 다양한 다른 아데노바이러스 혈청형으로부터의 야생형 E1A 단백질 서열이 본 명세서에서 서열번호 47 내지 54로 기재된다. 일부 실시예에서, 변형된 E1A 단백질은 서열번호 32 내지 37 또는 서열번호 47 내지 54 중 어느 하나와 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98%, 또는 적어도 99%의 서열 동일성을 갖는다. 본 명세서에서 고려된 변형된 E1A 단백질은 종양세포와 비교하여 정상세포에서 재조합 아데노바이러스의 복제 결함에 기여하는 단백질이다. 본 명세서에 개시된 변형된 E1A 단백질은 Ad5 E1A 단백질이다. 그러나, 상응하는 변형이 임의의 바람직한 혈청형에서 이루어질 수 있으며, 따라서 본 명세서에 포함된다. 예를 들어, 모든 종류의 인간 아데노바이러스는 Ad5에서 LTCHE(서열번호 32의 122 내지 126 잔기)에 상응하는 LXCXE 모티프를 포함한다. 유사하게, 2 내지 11 잔기 및 Y47H 및 C124G 치환의 결실은 Ad5와 관련하여 번호가 매겨지지만, 임의의 다른 혈청형으로 도입될 수 있다(모든 인간 아데노바이러스 종으로부터 E1A의 정렬을 제공하는 도 27 참조).
E3-RIDα/RIDβ 및 E3-14.7k: E3 유전자로부터 조기 발현된 단백질이다. E3-RIDα, E3-RIDβ, 및 E3-14.7k 단백질은 핵막에 국한되어 CD95(FasL 수용체)를 포함하는 다양한 수용체의 엔도시토시스(endocytosis) 및 분해를 일으키는 수용체 내재화(internalization) 및 분해 복합체(RID), 및 TNFR1 및 2(TNF/TRAIL 수용체)로 감염된 세포를 숙주 항바이러스 반응으로부터 보호한다. E3-RIDα, E3-RIDβ, 및 E3-14.7k 코딩서열은 상기 순서대로 서로 인접한다. 본 명세서의 일부 실시예에서, E3-14.7k의 정지코돈에 대한 E3-RIDα의 개시코돈은 결실되고, FKBP-융합 단백질의 코딩서열(예를 들어, AdSyn-CO312, AdSyn-CO313, AdSyn-CO335 및 AdSyn-CO440)로 대체되었다. Ad5 E3-RIDα, E3-RIDβ, 및 E3-14.7k의 아미노산 서열은 본 명세서에서 서열번호 65 내지 67로 기재된다.
E4orf1: E4 유전자로부터 생산된 아데노바이러스 단백질이다. 용어 "E4orf1 단백질"은 임의의 아데노바이러스 혈청형으로부터의 E4 유전자에 의해 생성된 E4orf1 단백질을 포함한다. 일례로, 야생형 Ad5 E4orf1 단백질의 아미노산 서열은 본 명세서에서 서열번호 38로 기재되고, PDZ- 결합 모티프의 결실을 갖는 변형된 Ad5 E4orf1 단백질은 본 명세서에서 서열번호 39로 기재된다. 또한, 다양한 다른 아데노바이러스 혈청형으로부터의 야생형 E4orf1 단백질 서열이 본 명세서에서 서열번호 55 내지 61로 기재된다. 일부 실시예에서, 변형된 E4orf1 단백질은 서열번호 38, 39 및 55 내지 61 중 어느 하나와 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98%, 또는 적어도 99%의 서열 동일성을 갖는다. 본 명세서에서 고려된 변형된 E4orf1 단백질은 종양세포와 비교하여 정상세포에서 재조합 아데노바이러스의 복제 결함에 기여하는 단백질이다. 본 명세서에 개시된 변형된 E4orf1 단백질은 Ad5 E4orf1 단백질이다. 그러나, 상응하는 변형이 임의의 바람직한 혈청형에서 이루어질 수 있으며, 따라서 본 명세서에 포함된다. 도 28의 E4orf1 정렬에서 나타낸 바와 같이, E4orf1 C-말단의 3개 잔기는 아데노바이러스 종 A, B, C, D, E 및 G에서 PDZ-결합 모티프를 구성한다. 일부 실시예에서, 재조합 아데노바이러스는 완전한 결실 E4orf1을 암호화한다.
E4orf6/7: 아데노바이러스 E4 유전자에 의해 암호화되는 단백질이다. 용어 "E4orf6/7 단백질"은 임의의 아데노바이러스 혈청형으로부터의 E4 유전자에 의해 생산된 E4orf6/7 단백질을 포함한다. 일례로, 야생형 Ad5 E4orf6/7 단백질의 아미노산 서열은 서열번호 40으로 기재되며, 야생형 Ad2 E4orf6/7 단백질의 아미노산 서열은 서열번호 64로 lrwo된다. 일부 실시예에서, E4orf6/7 단백질은 서열번호 40 또는 서열 번호 64 중 어느 하나와 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98%, 또는 적어도 99%의 서열 동일성을 갖는다. 본 명세서에서 고려된 변형된 E4orf6/7 단백질은 종양세포와 비교하여 정상세포에서 재조합 아데노바이러스의 복제 결함에 기여하는 단백질이다. 일부 실시예에서, 변형된 E4orf6/7 단백질은 이의 E2F 결합 부위를 파괴하거나 손상 및/또는 E2F 상호작용을 손상시키는 돌연변이(결실과 같은)를 포함한다. 다른 실시예에서, 변형된 E4orf6/7 단백질은 E2F4의 효율적인 전좌에 필요한 핵 위치 신호가 결실되거나손상된 변형을 포함한다. E4orf6/7의 예시적인 변형은 하기 섹션에서 더 논의된다.
표피성장인자수용체(EGFR): 세포외 단백질 리간드의 EGF 패밀리 구성원에 대한 세포표면수용체이다. EGFR은 ErbB-1 및 HER1으로도 알려져 있다. 많은 종류의 암은 EGFR의 과발현을 초래하는 돌연변이를 포함한다.
섬유: 아데노바이러스 섬유 단백질은 세포표면수용체에 결합을 매개하는 삼량체 단백질이다. 섬유 단백질은 긴 N-말단 샤프트 및 구형 C-말단 노브로 구성된다(도 23A 참조).
FK506 결합 단백질(FKBP): 단백질 접힘 샤페론으로 기능하는 진핵생물에서 발현되는 단백질 패밀리이다. FKBP는 라파마이신에 결합하는 능력에 대해 알려져 있다. 예시적인 FKBP 서열은 서열번호 44의 132 내지 238 잔기로서 본 명세서에 기재된다.
FKBP-라파마이신 결합(FRB): 라파마이신에 결합하는 라파마이신의 포유류 표적(mTOR)의 도메인이다. 예시적인 FRB 서열은 서열번호 42의 547 내지 636 잔기로서 본 명세서에 기재된다. 라파마이신 및 라파로그(rapalog)(AP21967로도 알려짐) 모두에 결합할 수 있는 FRB의 돌연변이 형태(본 명세서의 "FRB*"를 의미함)는 서열번호 43의 547 내지 636 잔기로서 본 명세서에 기재된다. FRB*는 서열번호 43의 620 잔기에 상응하는 인간 mTOR의 2098 위치에서 트레오닌이 류신으로 치환되는 것(T2098L)을 포함한다.
융합 단백질: 적어도 2개의 다른(이종) 단백질 또는 펩티드의 아미노산 서열을 포함하는 단백질이다. 융합 단백질은 예를 들어, 적어도 2개의 다른(이종) 단백질의 일부를 암호화하는 핵산 서열로부터 조작된 핵산 서열의 발현에 의해 생성될 수 있다. 융합 단백질을 생성하기 위해, 핵산 서열은 동일한 해독틀(reading frame) 내에 있어야 하며, 내부 정지코돈을 포함하지 않아야 한다. 또한, 융합 단백질, 특히 짧은 융합 단백질은 화학합성에 의해 생성될 수 있다.
이종: 이종 단백질 또는 폴리펩티드는 다른 공급원 또는 종으로부터 유래된 단백질 또는 폴리펩티드를 의미한다.
헥손: 주요한 아데노바이러스 캡시드 단백질이다. 예시적인 Ad5로부터의 헥손 서열은 본 명세서에서 서열번호 45로 기재된다. E451Q 치환을 포함하는 돌연변이의 헥손 서열은 본 명세서에서 서열번호 46으로 기재된다.
분리된: "분리된" 생물학적 성분(핵산 분자, 단백질, 바이러스 또는 세포와 같은)은 생물체의 세포 또는 조직에 있는 다른 생물학적 성분, 또는 생물체 자체로부터 실질적으로 분리 또는 정제되어, 다른 염색체 및 염색체 DNA와 RNA, 단백질 및 세포와 같은 성분이 자연적으로 발생한다. "분리된" 핵산 분자 및 단백질은 표준 정제 방법에 의해 정제된 것들을 포함한다. 또한, 상기 용어는 화학적으로 합성 된 핵산 분자 및 단백질뿐만 아니라 숙주 세포에서의 재조합 발현에 의해 제조된 핵산 분자 및 단백질을 아우른다.
마이크로 RNA(miRNA 또는 miR): 식물, 동물 및 바이러스에서 유전자 발현을 조절하는 단일가닥 RNA 분자이다. 마이크로 RNA를 암호화하는 유전자는 전사되어 일차 전사 마이크로 RNA(pri-miRNA)를 형성하고, 이는 전구체 마이크로 RNA(pre-miRNA)라고 불리는 짧은 머리핀(stem-loop) 분자를 형성하며, 이후, 내부핵산가수분해 절단으로 성숙한 마이크로 RNA를 형성한다. 성숙한 마이크로 RNA는 길이가 약 21 내지 23 뉴클레오티드이고, 부분적으로 하나 또는 그 이상의 표적 전령 RNA(mRNA)의 3'UTR에 상보적이다. 마이크로 RNA는 표적 mRNA의 절단을 촉진하거나 세포 전사체의 번역을 차단함으로써 유전자 발현을 조절한다. 본 명세서에 기재된 "간 특이적인 마이크로 RNA"는 간에서만 발현되는 마이크로 RNA, 또는 다른 장기 또는 조직 유형에 비해 간에서 더 많이 발현되는 마이크로 RNA와 같이 간에서 우선적으로 발현되는 마이크로 RNA이다.
변형: 핵산 또는 단백질 서열의 서열 변화이다. 예를 들어, 아미노산 서열 변형은 예를 들어, 치환, 삽입 및 결실, 또는 이들의 조합을 포함한다. 삽입은 아미노 및/또는 카복실 말단 융합뿐만 아니라 단일 또는 다중 아미노산 잔기의 내부 서열 삽입을 포함한다. 결실은 단백질 서열로부터 하나 또는 그 이상의 아미노산 잔기가 제거됨으로써 특징화된다. 일부 실시예에서, 변형(치환, 삽입 또는 결실과 같은)은 단백질의 특정 활성의 감소 또는 증진과 같은 기능의 변화를 초래한다. 본 명세서에서 사용된 "△" 또는 "델타"는 결실을 의미한다. 예를 들어, E1AΔLXCXE는 LXCXE 모티프의 결실을 갖는 E1A 폴리펩티드를 의미한다. 치환 변형은 적어도 하나의 잔기가 제거되고 다른 잔기가 그 자리에 삽입된 것 이다. 아미노산 치환은 전형적으로 단일 잔기이지만, 한번에 다수의 다른 위치에서 발생할 수 있다. 치환, 결실, 삽입 또는 이의 임의의 조합을 조합하여 최종 돌연변이 서열을 얻을 수 있다. 이러한 변형은 변형을 암호화하는 DNA를 생산함으로써 단백질을 암호화하는 DNA에서 뉴클레오티드의 변형에 의해 일어날 수 있다. 공지된 서열을 갖는 DNA의 미리 결정된 부위에서 삽입, 결실 및 치환 돌연변이를 만드는 기술은 당업계에 잘 알려져 있다. "변형된" 단백질, 핵산 또는 바이러스는 상술한 바와 같이 하나 또는 그 이상의 변형을 갖는 것이다.
신생물, 악성종양, 암 및 종양: 신생물은 과도한 세포분열로 인한 조직 또는 세포의 비정상적인 성장이다. 신생물성 증식은 종양을 일으킬 수 있다. 개인의 종양의 양은 종양의 수, 부피 또는 무게로 측정될 수 있는 "종양 부하(tumor burden)"이다. 전이하지 않는 종양을 "양성"이라 한다. 주변 조직을 침범 및/또는 전이할 수 있는 종양을 "악성"이라 한다. 또한, 악성 종양을 "암"이라고 한다.
혈액암은 혈액 또는 골수암이다. 혈액학적(또는 혈액성) 암의 예로, 급성 백혈병(예를 들어, 급성 림프구성 백혈병, 급성 골수성 백혈병, 급성 골수아구성 백혈병 및 골수아구성, 전골수성, 골수단핵구성, 단핵구성 및 적백혈병), 만성 백혈병(예를 들어, 만성 골수세포(과립구성) 백혈병, 만성 골수성 백혈병, 및 만성 림프구성 백혈병), 진성 적혈구증가증, 림프종, 호지킨병, 비-호지킨 림프종(저등도(indolent) 및 고등도 형태), 다발성 골수종, 발덴스트롬 마크로글로불린혈증, 중쇄병, 골수이형성증후군, 모발상세포 백혈병 및 골수이형성증을 포함하는 백혈병을 포함한다. 몇몇 경우, 림프종이 고형종양으로 간주된다.
고형종양은 일반적으로 낭종이나 액체를 포함하지 않는 비정상적인 조직이다. 고형종양은 양성 또는 악성일 수 있다. 다른 유형의 고형종양은 세포 형태(예를 들어, 육종, 암종 및 림프종)의 유형에 따라 명명된다. 육종 및 암종과 같은 고형종양의 예로, 섬유육종, 점액육종, 지방육종, 연골육종, 골육종 및 기타 육종, 활막종, 중피종, 유윙종양, 평활근육종, 횡문근육종, 결장암, 악성림프종, 췌장암, 유방암, 폐암, 난소암, 전립선암, 간세포암종, 편평세포암종, 기저세포암, 선암, 한선암종, 거대종격동전이암, 유두갑상선암종, 크롬친화성세포종피지선암종(pheochromocytomas sebaceous gland carcinoma), 유두암종, 인간유두종바이러스(HPV) 감염된 신생물, 유두선암(papillary adenocarcinomas), 수질암종, 기관지암, 신장암, 간세포암, 담관암, 융모암, 윌름스종양, 자궁경부암, 고환종양, 정상피종, 방광암종, 흑색종, 및 중추신경계종양(예를 들어, 신경교종(예를 들어, 뇌간신경교종 및 혼합된 신경교종), 성상교모세포종(다형성교모세포종이라고도 알려짐), 중추신경계 림프종, 배아세포종, 수모세포종, 슈반종 두개인두종(Schwannoma craniopharyogioma), 상의세포종, 송과체부종양, 혈관모세포종, 청신경종, 핍지교종, 뇌수막종, 신경아세포종, 망막아세포종 및 뇌전이암)를 포함한다.
종양 살상 바이러스: 암/종양세포와 같은 증식성 질환의 세포를 선택적으로 살상시키는 바이러스이다. 암세포의 살상은 생균수를 결정하거나, 암세포에서 세포변성 효과, 세포살상 또는 바이러스 단백질의 합성(예를 들어, 물질대사 표지, 면역블롯, 또는 복제에 필수적인 바이러스 유전자의 RT-PCR), 또는 종양의 크기 감소를 검출하는 것과 같은 당업계에서 확립된 임의의 방법에 의해 검출될 수 있다.
작동가능하게 연결된: 첫번째 핵산 서열은 첫번째 핵산 서열이 두번째 핵산 서열과 기능적인 관계에 놓일 때, 두번째 핵산 서열과 작동가능하게 연결된다. 예를 들어, 프로모터가 코딩 서열의 전사 또는 발현에 영향을 주면 프로모터는 코딩 서열에 작동가능하게 연결된다. 일반적으로, 작동가능하게 연결된 DNA 서열은 연속적이며, 두개의 단백질 코딩 영역을 합치는 데 필요한 경우 동일한 해독틀에서 결합한다.
약학적으로 허용가능한 담체: 본 명세서에서 유용한 약학적으로 허용가능한 담체(비히클)는 통상적이다. Re분gton’s Pharmaceutical Sciences, by E. W. Martin, Mack Publishing Co., Easton, PA, 15th Edition(1975)는 하나 또는 그 이상의 치료 화합물, 분자 또는 제제(예를 들어, 본 명세서에 개시된 재조합 바이러스)의 약학적인 전달에 적합한 조성물 및 제형을 기술한다.
일반적으로, 담체의 성질은 사용되는 특정 투여 방식에 의존할 것이다. 예를 들어, 통상적으로 비경구용 제형은 물, 생리식염수, 평형염류용액, 수성 덱스트로스, 글리세롤 또는 비히클과 같은 약학적으로 및 생리학적으로 허용가능한 유체를 포함하는 주사가능한 유체를 포함한다. 고체 조성물(예를 들어, 분말, 환제, 정제 또는 캡슐 형태)의 경우, 통상의 무독성 고체 담체는 예를 들어, 의료용 만니톨, 락토오스, 전분, 또는 마그네슘 스테아레이트를 포함할 수 있다. 또한, 생물학적으로 중성인 담체, 투여되는 약학적 조성물은 습윤제 또는 유화제, 방부제, 및 pH 완충제 및 예를 들어, 아세트산나트륨 또는 솔비탄 모노라우레이트(sorbitan monolaurate) 등과 같은 소량의 무독성 보조 물질을 포함할 수 있다.
폴리펩티드, 펩티드 또는 단백질: 단량체가 아마이드 결합을 통해 함께 연결된 아미노산 잔기인 중합체이다. 아미노산이 알파-아미노산인 경우, L-광학이성질체 또는 D-광학이성질체가 사용될 수 있다. 용어 "폴리펩티드", "펩티드" 및 "단백질"은 본 명세서에서 상호교환적으로 사용된다. 이들 용어는 하나 또는 그 이상의 아미노산 잔기가 상응하는 천연 아미노산뿐만 아니라 천연 아미노산 중합체 및 비-천연 아미노산 중합체의 인공적인 화학 모방물인 아미노산 중합체에 적용된다. 용어 "잔기" 또는 "아미노산 잔기"는 단백질, 폴리펩티드, 또는 펩티드에 포함된 아미노산에 대한 언급을 포함한다.
폴리펩티드에서의 보존적 치환은 유사한 생화학적 특성을 갖는 다른 아미노산 잔기에 대한 단백질 서열 내의 하나의 아미노산 잔기의 치환이다. 일반적으로, 보존적 치환은 생성된 폴리펩티드의 활성에 거의 또는 전혀 영향을 미치지 않는다. 예를 들어, 하나 또는 그 이상의 보존적 치환(예를 들어, 1, 2, 3, 4 또는 5개 이하의 치환)을 포함하는 단백질 또는 펩티드는 야생형 단백질 또는 펩티드의 구조 및 기능을 보유한다. 폴리펩티드는 예를 들어, 부위 특이적 변이 또는 PCR과 같은 표준절차를 사용하여 폴리펩티드를 암호화하는 뉴클레오티드 서열을 조작함으로써 하나 또는 그 이상의 보존적 치환을 포함하도록 생성될 수 있다. 일례로, 이러한 변이체는 항체 교차-반응성 또는 면역반응을 유도하는 능력을 시험함으로써 용이하게 선택될 수 있다. 보존적 치환의 예는 하기와 같다.
Figure pct00001
보존적 치환은 일반적으로 (a) 예를 들어, 시트 또는 나선형 형태와 같은 치환 영역에서의 폴리펩티드 골격구조, (b) 표적 부위에서 분자의 전하 또는 소수성, 또는 (c) 곁사슬의 부피를 유지한다.
일반적으로 단백질 특성에서 가장 큰 변화를 가져올 것으로 예상되는 치환은 예를 들어, (a) 세릴 또는 트레오닐과 같은 친수성 잔기가 류실, 이소류실, 페닐알라닐, 발릴 또는 알라닐과 같은 소수성 잔기로 치환됨; (b) 시스테인 또는 프롤린이 다른 잔기로(또는 이들에 의해) 치환됨; (c) 리실, 아르기닐, 또는 히스타딜과 같은 양전하를 띠는 곁사슬을 갖는 잔기가 글루타밀 또는 아스파르틸과 같은 음전하를 띠는 잔기로 치환됨(또는 이들에 의해); 또는 (d) 페닐알라닌과 같은 부피가 큰 곁사슬을 갖는 잔기가 글리신과 같은 곁사슬을 갖지 않는 잔기로 치환되는 변화인 비-보존적일 것이다.
질병의 예방, 치료 또는 개선: 질병을 "예방"하는 것은 질병의 완전한 발달을 저해하는 것을 의미한다. "치료"는 질병 또는 병적 상태가 발달하기 시작한 후 징후나 증상을 호전시키는 치료적 개입을 의미한다. "개선"은 질병의 징후 또는 증상의 수 또는 중증도 감소를 의미한다.
프로모터: 핵산(예를 들어, 유전자)의 전사를 지시/개시하는 DNA 영역이다. 프로모터는 전사 시작부위 근처에 필요한 핵산 서열을 포함한다. 일반적으로, 프로모터는 그들이 전사하는 유전자 근처에 위치한다. 또한, 프로모터는 선택적으로 먼 인핸서(enhancer) 또는 전사의 개시 위치로부터 수천 염기쌍만큼 위치될 수 있는 리프레서(repressor) 요소를 포함한다. "항시성 프로모터"는 연속적으로 활성이 있으며, 외부 신호 또는 분자에 의해 조절을 받지 않는 프로모터이다. 반면, "유도성 프로모터"의 활성은 외부 신호 또는 분자(예를 들어, 전사인자 또는 테트라사이클린)에 의해 조절된다.
단백질 IX(pIX): 헥손 단백질과 결합하는 아데노바이러스 캡시드의 부수적 인 성분이다.
정제된: 용어 "정제된"은 절대적인 순도를 필요로 하지 않는다; 오히려 이는 상대적 용어를 의미한다. 따라서, 예를 들어, 정제된 펩티드, 단백질, 바이러스, 또는 다른 활성 화합물은 자연적으로 결합된 단백질 및 다른 오염물로부터 전체 또는 부분적으로 분리된 것이다. 특정 실시예에서, 용어 "실질적으로 정제된"은 세포, 세포 배양배지, 또는 다른 미가공 조제물로부터 분리되고, 분획화하여 단백질, 세포 잔해, 및 다른 성분과 같은 초기 조제물의 다양한 성분이 제거된 펩티드, 단백질, 바이러스 또는 다른 활성 화합물을 의미한다.
라파마이신: 면역억제 및 항증식성이 알려진 작은 분자이다. 시롤리무스라고도 알려진 라파마이신은 세균인 스트렙토마이세스 하이그로스코피쿠스(Streptomyces hygroscopicus)의 산물로서 처음 발견된 매크로라이드이다. 라파 마이신은 결합하여 mTOR의 활성을 저해한다.
Rb-결함세포: 종양 억제인자 Rb의 수준이 정상 또는 대조군 세포, 또는 Rb 경로가 파괴되거나 비활성인 세포에서의 Rb 수준에 비해 감소된 세포(예를 들어, 종양세포)이다. 용어 "Rb 경로" 또는 "Rb 신호전달경로"는 적어도 부분적으로 pRb/p107, E2F-1/-2/-3, 및 G1 사이클린/cdk 복합체를 포함하는 pRb 활성에 영향을 미치는 분자를 의미한다. 현재 알려져 있지 않은 분자도 이 정의에 포함될 수 있다.
Rb/p16/사이클린 D:cdk4/E2F 복제가 손상되거나 결함된 아데노바이러스: 세포의 감염시 Rb/p107/p130/p16/E2F/CDK-사이클린 체크 포인트를 포함하는 정상 수준의 기능적인 세포 Rb/p107/p130/p16/사이클린:CDK/E2F 경로 단백질의 존재 하에서 부분적으로 또는 완전히 약화된 복제를 나타내는 아데노바이러스(예를 들어, 변형된/재조합 아데노바이러스)이다. 예를 들어, 감염된 세포가 Rb/p16 경로가 손상되거나 결함된 경우(즉, 감염된 세포가 Rb/p16 경로에서 완전히 기능적인 Rb 또는 다른 단백질을 정상 수준으로 발현하지 못하는 경우), Rb/p16/E2F 경로 복제가 손상된 아데노바이러스의 복제는 정상적으로 진행될 것 이다. 반대로, 세포가 정상 수준의 기능적인 Rb(예를 들어, 정상 활성을 갖는 Rb, 본 명세서에서 "Rb 발현세포"라고도 함)를 발현하는 경우, Rb 복제가 손상되거나 결함된 아데노 바이러스의 복제는 약화되거나 방지된다. 세포는 정상 수준의 Rb(예를 들어, Rb 유전자의 조절영역으로의 돌연변이)를 발현하지 못하거나 정상적인 Rb 활성보다 낮은 돌연변이된 Rb를 발현함으로써 Rb를 손상시키거나 결함시킬 수 있다. 정상 수준의 Rb 및 정상 Rb 활성 수준은 동일한 유형의 건강한, 질병이 없는 세포에서 발견된다. 따라서, Rb가 손상된 세포는 돌연변이된 Rb 유전자를 포함한다. 선택적으로, Rb가 손상된 세포는 Rb 유전자가 전부 또는 부분적으로 결실된 게놈을 포함한다. Rb가 손상된 세포는 암/종양세포일 수 있다. 정상적인 Rb 기능의 상실을 초래할 수 있는 다른 게놈 병변으로는 CDK 돌연변이, 사이클린 돌연변이 및 증폭, p16 돌연변이 및/또는 후생학적 사일런싱, p107 돌연변이, p130 돌연변이, 및 성장인자 수용체 경로 돌연변이가 있으나, 이에 제한되지 않는다.
Rb/p16 종양 억제인자 경로 또는 Rb/p16 경로: 망막 아세포종(Rb) 단백질, 및 Cdk, E2F, 비정형 단백질 키나아제 C, 및 Skp2를 포함하나, 이에 한정되지 않는 경로에서 다른 단백질/단백질 패밀리를 포함하는 전체 신호전달 경로를 의미한다.
용어 "Rb/p16 종양 억제인자 경로가 손상되거나 결함된"은 신호전달경로에서 하나 또는 그 이상의 분자가 손상되거나 결함되었음을 의미한다. 예를 들어, 정상수준 또는 단백질을 발현하지 못하거나 정상적인 활성보다 낮은 활성을 갖는 돌연변이된 단백질을 발현함으로써 경로의 기능이 비정상적으로 된다. 이러한 결함은 유리 E2F의 높은 발현 수준 및 E2F 프로모터의 높은 활성을 초래한다. 따라서, 세포는 정상 수준의 단백질을 발현하지 못하거나 Rb/p16 종양 억제인자 경로에서 정상 이하의 활성을 갖는 돌연변이된 단백질을 발현함으로써 Rb/p16 경로가 손상되거나 결함될 수 있다.
재조합: 재조합 핵산 분자, 단백질 또는 바이러스는 자연적으로 발생하지 않는 서열을 갖는 것이거나 달리 분리된 2개 서열의 인위적인 조합에 의해 만들어진 서열을 갖는다. 이러한 인위적인 조합은 화학적 합성 또는 유전공학기술에 의한 것과 같이 핵산 분자의 분리된 단편의 인위적인 조작에 의해 달성될 수 있다. 또한, 용어 "재조합"은 천연 핵산 분자, 단백질 또는 바이러스 일부의 첨가, 치환, 또는 결실에 의해서만 변경된 핵산, 단백질 및 바이러스를 포함한다.
복제 결함: 비-종양세포(종양세포에 비해)에서 "복제 결함"을 나타내는 아데노바이러스는 종양세포와 비교하여 정상세포에서 감소된 바이러스 복제를 나타내는 아데노바이러스를 의미한다. 복제 결함은 예를 들어, 바이러스 후기 단백질 발현의 결함, 바이러스 DNA 합성 감소, 감소된 E2F 표적 유전자(예를 들어, 사이클린 A 및 B)로의 유도 능력, 감소된 S기 진입 능력 및/또는 종양세포와 비교하여 정상세포에서 감소된 세포 살상 유도능력으로 입증된다.
복제 결함 바이러스: 주어진 표현형(예를 들어, 조절되지 않은 E2F 경로를 갖는 종양세포)을 갖는 미리 결정된 세포 집단에서 세포 증식을 우선적으로 저해하거나, 세포용해를 유발하거나, 세포살상(총괄하여 살상로 간주됨)을 유도하는 바이러스이다. 이러한 바이러스는 세포 증식을 감소 또는 저해하는 능력, 세포 용해를 일으키거나, 세포살상을 유도하거나, 미리 결정된 세포 표현형(예를 들어, 정상, 비-종양세포)을 갖지 않는 세포에서 복제할 수 없거나 제한된다.
서열 동일성: 둘 또는 그 이상의 핵산 서열, 또는 둘 또는 그 이상의 아미노산 서열 간의 동일성 또는 유사성은 서열 간의 동일성 또는 유사성의 관점에서 표현된다. 서열 동일성은 비율 동일성의 관점에서 측정될 수 있다; 비율이 높을수록 서열이 더 유사하다. 핵산 또는 아미노산 서열의 상동성(homolog) 또는 이종상동성(ortholog)은 표준 방법을 사용하여 정렬될 때 비교적 높은 정도의 서열 동일성/유사성을 갖는다. 이러한 상동성(homology)은 더 관련이 없는 종(예를 들어, 인간 및 C. elegans 서열)에 비해 더 밀접한 관련이 있는 종(예를 들어, 인간과 마우스 서열)에서 유래된 이종상동성(orthologous) 단백질이나 cDNA일 때 더 중요하다.
비교를 위한 서열의 정렬 방법은 당업계에 잘 알려져 있다. 다양한 프로그램 및 정렬 알고리즘은 하기에서 설명된다: Smith & Waterman, Adv. Appl. Math. 2:482, 1981; Needleman & Wunsch, J. Mol. Biol. 48:443, 1970; Pearson & Lipman, Proc. Natl. Acad. Sci. USA 85:2444, 1988; Higgins & Sharp, Gene, 73:237-44, 1988; Higgins & Sharp, CABIOS 5:151-3, 1989; Corpet et al., Nuc. Acids Res. 16:10881-90, 1988; Huang et al. Computer Appls. in Biosciences 8, 155-65, 1992; 및 Pearson et al., Meth. Mol. Bio. 24:307-31, 1994. Altschul et al., J. Mol. Biol. 215:403-10, 1990은 서열 정렬 방법 및 상동성 계산에 대한 상세한 고려사항을 제시한다.
NCBI Basic Local 정렬 Search Tool(BLAST)(Altschul et al., J. Mol. Biol. 215:403-10, 1990)는 서열 분석 프로그램인 blastp, blastn, blastx, tblastn 및 tblastx와 관련하여 사용하기 위해 국립생물정보센터(NCBI) 및 인터넷을 포함한 여러 소스에서 사용할 수 있다. 추가적인 정보는 NCBI 웹사이트에서 찾을 수 있다.
혈청형: 특성 항원에 의해 구별되는 밀접하게 관련된 미생물(예를 들어, 바이러스)의 그룹이다.
개체: 인간과 인간이 아닌 포유류를 포함하는 범주인 살아있는 다세포 척추동물이다.
합성: 실험실에서 인위적인 방법에 의해 생산되는 것으로, 예를 들어, 합성 핵산 또는 단백질은 실험실에서 화학적으로 합성될 수 있다.
표적 리간드: 본 명세서에 기재된 "표적 리간드"는 재조합 아데노바이러스를 표적 리간드에 특이적인 수용체 또는 결합 단백질을 발현하는 특정 세포 유형으로 유도하는 단백질이다. 일부 실시예에서, 표적 리간드는 종양에서 과발현된 세포 표면 단백질(예를 들어, EGFR)에 특이적인 항체이다.
치료제: 개체에게 적절하게 투여될 때 원하는 치료 또는 예방 효과를 유도할 수 있는 화합물, 소분자, 재조합 바이러스 또는 다른 조성물, 예컨대 안티센스 화합물, 항체, 펩티드 또는 핵산 분자이다. 예를 들어, 암 치료제는 암의 발생 또는 전이를 예방 또는 저해하는 제제를 포함한다.
치료상으로 유효량: 제제로 치료되는 개체, 또는 세포에서 원하는 효과를 달성하기에 충분한 특정 약제 또는 치료제(예를 드렁, 재조합 바이러스)의 양이다. 제제의 유효량은 치료되는 개체 또는 세포 및 치료학적 조성물의 투여 방식을 포함하나, 이에 한정되지 않는 여러 인자에 의존할 수 있다.
U엑손: 초기 E3 영역과 섬유 유전자(Tollefson et al., J Virol 81(23): 12918-12926) 사이의 l 가닥(왼쪽으로 전사)에 위치한 개방형 해독틀이다.
벡터: 벡터는 숙주세포에서 복제 및/또는 통합하는 벡터의 능력을 손상시키지 않으면서 외래 핵산을 삽입 할 수 있게하는 핵산 분자이다. 벡터는 숙주세포에서 복제기점과 같은 복제를 허용하는 핵산 서열을 포함할 수 있다. 또한, 벡터는 하나 또는 그 이상의 선택 가능한 마커 유전자 및 다른 유전요소를 포함할 수 있다. 발현벡터는 삽입된 유전자 또는 유전자의 전사 및 번역을 허용하기 위해 필요한 조절서열을 포함하는 벡터이다.
달리 설명되지 않는 한, 본 명세서에서 사용되는 모든 기술 및 과학 용어는 본 발명이 속하는 기술 분야의 당업자에 의해 일반적으로 이해되는 것과 동일한 의미를 갖는다. 단수의 용어 "하나(a)", "하나(an)"및 "그(the)"는 문맥에 달리 명시되어 있지 않는 한 복수의 개체를 포함한다. "A 또는 B를 포함하는"은 A, 또는 B, 또는 A 및 B를 포함하는 것을 의미한다. 핵산 또는 폴리펩티드에 대해 주어진 모든 염기 크기 또는 아미노산 크기, 및 모든 분자량(molecular weight) 또는 분자질량(molecular mass) 값은 근사치이고, 설명을 위해 제공된다. 본 명세서에 기술된 것들과 유사하거나 동등한 방법 및 재료가 본 발명의 실시 또는 테스트에 사용될 수 있지만, 적합한 방법 및 재료는 하기에 기술된다. 본 명세서에 언급된 모든 간행물, 특허출원, 특허 및 기타 참고문헌은 그 전체가 참고문헌으로 인용된다. 상충하는 경우, 용어의 설명을 포함하여 본 명세서가 우선한다. 또한, 재료, 방법 및 실시예는 단지 예시적인 것이며 이에 제한되지 않는다.
Ⅲ. 재조합 아데노바이러스
E2F가 조절되지 않은 종양세포에서 선택적으로 복제할 수 있는 재조합 아데노바이러스가 본 발명에 의해 제공된다. 본 명세서에 개시된 재조합 아데노바이러스는 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 변형된 또는 결실된 E4orf6/7 단백질, 또는 이들의 임의의 조합을 암호화하는 게놈을 갖는다. E1A, E4orf1 및/또는 E4orf6/7 돌연변이의 결과로서, 재조합 아데노바이러스는 정상(즉, 비-종양)세포에서 복제 결함을 나타내지만, 종양세포에서 복제하고 용해시키는 능력을 보유한다. 일 실시예에서, 재조합 아데노바이러스는 동일한 세포 유형(예를 들어, 유방암세포 대 정상유방세포)의 종양세포에 비해 정상(즉, 비-종양)세포에서 적어도 20%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 적어도 90%, 적어도 95%, 적어도 98%, 또는 적어도 99%의 감소된 복제를 가진다. 예를 들어, 감염된 정상세포 및 감염된 종양세포에서 감염성 입자의 수를 비교함으로써 결정된다.
본 발명에서 제공된 재조합 아데노바이러스는 선택적으로 특정 세포 유형을 표적화하고, 간에서 표적화 및 복제를 저해하고, 공통적인 아데노바이러스 혈청형에 대한 기존의 중화 항체를 회피하기 위한 추가적인 변형을 포함한다. 또한, 종양 살상 아데노바이러스를 암호화하는 재조합 핵산 분자가 제공된다.
EF1α 프로모터의 조절하에 GFP-루시퍼라제를 발현하는 재조합 리포터 아데노바이러스 유전자 발현벡터가 본 발명에서 추가로 제공된다. 일부 실시예에서, 개시된 리포터 아데노바이러스는 간에서 표적화 및 복제를 저해하는 하나 또는 그 이상의 변형을 포함한다. 또한, 재조합 리포터 아데노바이러스를 암호화하는 재조합 핵산 분자가 제공된다.
A. 종양 살상 변형
본 명세서에 개시된 특정 종양 살상 변형은 아데노바이러스 5(Ad5) 게놈 서열을 참조하여 기술된다. 그러나, 임의의 인간 아데노바이러스 혈청형에서 동일한 변형 및 결실이 이루어질 수 있다. 일 실시예에서, 재조합 아데노바이러스는 Ad34이다. 다른 특정 실시예에서, 재조합 아데노바이러스는 Ad11 또는 Ad37이다. 도 27 및 도 28은 인간 아데노바이러스 종 중에서 E1A 및 E4orf1 영역의 서열 유사성을 나타낸다.
E1A의 CR1 영역은 세포의 E2F에 대한 서열 및 구조적인 상동성을 갖고, E2F-Rb 상호작용과 경쟁한다. 보존된 E1A 소수성 잔기 L43, L46 및 Y47은 Rb와의 상호작용을 위한 소수성 앵커로서 작용한다. L43, L46 및/또는 Y47의 D, E, H, K 또는 R과 같은 극성 아미노산으로의 돌연변이는 E1A-Rb 상호작용을 제거할 것 이다. 일부 실시예에서, 재조합 아데노바이러스는 E1A에서 E1A-Rb 상호작용을 파괴하기 위해 Y74H 돌연변이를 포함한다.
E1A는 LXCXE 모티프를 통해 Rb와 강력하게 상호작용한다. 첫 번째 류신과 중앙 시스테인의 곁사슬이 Rb의 B 박스 모티프의 작은 소수성 포켓에 결합하기 때문에, 이 잔기의 결실 또는 작거나(예를 들어, G) 극성 아미노산(예를 들어 D, E, H, K 또는 R)으로의 돌연변이는 E1A-Rb 상호작용을 제거한다. 따라서, 일부 실시예에서, 재조합 아데노바이러스는 E1A에서 LXCXE 모티프(ΔLXCXE) 또는 C124G 치환의 결실을 포함한다.
E1A 잔기 C124 및 Y47은 모두 Rb에 결합하고, Rb를 불활성화시키는데 중요하다. 따라서, 일부 실시예에서, 재조합 아데노바이러스는 이중 돌연변이 Y/F47H 및 C124G를 암호화하지만, 이들 잔기 또는 부위에 대한 임의의 돌연변이(상술한 바와 같이)는 E1A-Rb 상호작용을 약화시킬 것으로 여겨진다. 따라서, Rb-E1A 상호작용을 파괴시키는 임의의 잔기의 돌연변이 또는 결실이 본 발명에서 고려된다.
E1A의 잔기 2 내지 11의 결실은 P300/CBP 상호작용을 제거하고, DP-1 상호작용을 방해하고, E2F 표적을 상향조절하는 E1A의 능력을 감소시킨다. 또한, 보존된 R2 또는 H3 잔기의 글리신 또는 알라닌 돌연변이, 또는 다른 아데노바이러스 혈청형으로부터의 소수성 I/L/V4의 극성 잔기 돌연변이(예를 들어, D, E, H, K, 또는 R)와 같은 E1A 2 내지 11 잔기에서의 점 돌연변이가 이 상호작용을 제거하기 위해 본 발명에서 고려된다(도 27의 E1A 정렬 참조).
E4orf1은 C-말단에서 PDZ-결합 모티프를 통해 PDZ 모티프를 포함하는 세포 단백질과 상호작용한다. 본 명세서에 개시된 일부 실시예에서, E4orf1의 마지막 3개의 아미노산은 이의 PDZ-결합 모티프를 제거하기 위해 결실된다. 또한, V, L, 또는 I와 같은 큰 소수성 잔기에 대한 Ad5 E4orf1의 고도로 보존된 S126의 점 돌연변이; 또는 D, E, H, K, 또는 R과 같은 극성 잔기에 대한 Ad5 E4orf1의 V128의 점 돌연변이가 본 발명에서 고려된다. 이러한 치환은 E4orf1의 PDZ-결합 활성을 제거하고, E4orf1의 이러한 형질전환 기능을 제거하는 것으로 여겨진다. E4orf1에서의 동일한 결실 및/또는 돌연변이는 Ad34와 같은 다른 아데노바이러스 혈청형에서 만들어질 수 있다. 또한, E4orf1의 완전한 결실이 개시된다.
본 발명은 재조합 아데노바이러스의 게놈이 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 변형된 또는 결실된 E4orf6/7 단백질, 또는 이들의 임의의 조합을 암호화하는 재조합 아데노바이러스를 제공하며, 상기 재조합 아데노바이러스는 정상세포에 비해 종양세포에서 복제 결함을 나타낸다.
일부 실시예에서, 게놈은 변형된 E1A 단백질 및 변형된 또는 결실된 E4orf1 단백질을 암호화한다. 다른 실시예에서, 게놈은 변형된 E1A 단백질 및 결실된 E4orf6/7 단백질을 암호화한다. 또 다른 실시예에서, 게놈은 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질을 암호화한다.
일부 실시예에서, 재조합 아데노바이러스의 변형된 E1A 단백질은 LXCXE 모티프의 결실; 2 내지 11 잔기의 결실; C124G 치환; Y47H 치환; Y47H 치환 및 C124G 치환; 또는 Y47H 치환, C124G 치환 및 2 내지 11 잔기의 결실을 포함한다. 이러한 돌연변이는 서열번호 32의 아미노산 서열을 갖는 Ad5 E1A 이다; 그러나, E1A 서열이 고도로 보존되기 때문에 임의의 다른 인간 아데노바이러스에서 상응하는 돌연변이가 만들어질 수 있다(도 27 참조).
일부 실시예에서, 변형된 E4orf1 단백질은 PDZ-결합 모티프의 결실을 포함한다. 다른 실시예에서, E4orf1 단백질은 C-말단의 10개 아미노산 또는 20개 아미노산의 결실, 또는 D68의 A, K, R, P, F, G 또는 L로의 돌연변이를 포함한다.
일부 실시예에서, 변형된 E4orf6/7 단백질은 이의 E2F 결합부위를 파괴 또는 손상 및/또는 E2F 상호작용을 손상시키는 돌연변이(예를 들어, 결실)를 포함한다. 다른 실시예에서, 변형된 E4orf6/7 단백질은 E2F4의 효율적인 전좌에 필요한 핵 위치 신호를 삭제하거나 손상시키는 변형을 포함한다.
특히 제한하지 않는 예로서, 재조합 아데노바이러스의 게놈은 LXCXE 모티프의 결실을 포함하는 변형된 E1A 단백질 및 결실된 E4orf6/7 단백질을 암호화한다(예를 들어, AdSyn-CO181, AdSyn-CO312, AdSyn-CO313, AdSyn-CO335, AdSyn-CO442 참조);
LXCXE 모티프의 결실을 포함하는 변형된 E1A 단백질, PDZ-결합 모티프의 결실을 포함하는 변형된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO285 참조);
LXCXE 모티프의 결실을 포함하는 변형된 E1A 단백질, 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO286 참조);
C124G 치환을 포함하는 변형된 E1A 단백질 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO287 참조);
C124G 치환을 포함하는 변형된 E1A 단백질, PDZ-결합 모티프의 결실을 포함하는 변형된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO288 참조);
C124G 치환을 포함하는 변형된 E1A 단백질, 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO289 참조);
2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO290 참조);
2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질, PDZ-결합 모티프의 결실을 포함하는 변형된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO291 참조);
2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질, 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO292 참조);
Y47H 치환 및 C124G 치환을 포함하는 변형된 E1A 단백질, 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO293 참조);
Y47H 치환 및 C124G 치환을 포함하는 변형된 E1A 단백질, PDZ-결합 모티프의 결실을 포함하는 변형된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO294 참조);
Y47H 치환 및 C124G 치환을 포함하는 변형된 E1A 단백질, 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO295 참조);
Y47H 치환, C124G 치환 및 2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질, 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO296 참조);
Y47H 치환, C124G 치환 및 2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질, PDZ-결합 모티프의 결실을 포함하는 변형된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질(예를 들어, AdSyn-CO297 ); 또는
Y47H 치환, C124G 치환 및 2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질, 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질을 포함하는 변형 된 E1A 단백질 (예를 들어, AdSyn-CO298 참조).
특정 실시예에서, 재조합 아데노바이러스의 게놈은 서열번호 6 내지 8, 10 내지 12, 14, 15, 18 내지 20, 22 내지 26, 30, 31 및 82 내지 87 중 임의의 하나와 적어도 90%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98% 또는 적어도 99%의 상동성을 갖거나, 재조합 아데노바이러스의 게놈은 서열번호 6 내지 8, 10 내지 12, 14, 15, 18 내지 20, 22 내지 26, 30, 31, 82 내지 87, 및 92 내지 97 중 임의의 하나를 포함하거나 구성하고,
같은 세포 유형(예를 들어, 유방암세포 vs. 정상유방세포)의 종양세포에 비해 정상(즉, 비-종양)세포에서 적어도 20%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 적어도 90%, 적어도 95%, 적어도 98%, 또는 적어도 99% 감소된 복제를 갖는다. 예를 들어, 정상세포와 종양세포에서 감염성 입자의 수를 비교함으로써 결정된다.
일부 실시예에서, 재조합 아데노바이러스의 게놈은 E3-RIDα/RIDβ 및 E3-14.7k 코딩서열의 결실을 포함한다.
B. 간 비표적화 변형
본 명세서에 개시된 재조합 아데노바이러스는 간에서 바이러스를 비표적화하는 변형을 추가로 포함할 수 있다. Ad5 헥손은 혈중에서 X 인자에 결합할 수 있으며, 간에서 쿠퍼(Kuppfer) 세포에 의한 흡수를 유도하여 전신성 전파를 예방하고 염증을 제한할 수 있다. 이를 극복하기 위해, 재조합 아데노바이러스는 E1에서의 추가적인 게놈 변형 및 간에서의 흡수 및 발현을 방지하는 코어 모듈을 포함하도록 조작되었다.
이러한 추가적인 변형을 포함하는 게놈 모듈을 시험하고, 생체 내 사용 및 유전자 전달을 위한 Ad5 발현벡터를 생성하기 위해 E1A/E1 유전자가 결실되었고 EF1α 유도된 루시퍼라제-GFP 융합체로 대체되었다. 정맥 내 투여시, AdSyn-CO199는 루시퍼라제 생체발광에 의해 입증되는 바와 같이 간에서 주로 축적되었다(도 22 참조).
간에서의 표적 발현을 방지하기 위해, 바이러스는 간에서 특이적으로 발현되는 마이크로 RNA에 대한 E1A의 3'UTR 결합부위를 포함하도록 조작되었다. 특정 실시예에서, miR122는 이의 발현 및 결합부위가 인간 및 마우스의 간세포에서 보존되므로 간 특이적인 마이크로 RNA로 선택되었다. 일부 실시예에서, 간 특이적인 miR122에 대한 2개의 마이크로-RNA 결합부위는 바이러스 유전자 발현 및 세포 염증반응을 유도하는 간에서의 잔류 바이러스 흡수를 방지하기 위해 E1A의 3'UTR에 삽입되었다. Adsyn-CO199와 달리, AdSyn-CO200(하기 도 22 및 실시예 2 참조)은 간에서 루시퍼라제 발현을 유도하지 않는다.
X 인자에 결합하는 Ad5 헥손을 통한 간에서의 바이러스 흡수 및 격리를 막기위해, 바이러스는 간 흡수를 막는 헥손(E451Q)에서 추가적인 돌연변이로 조작되었다. AdSyn199 및 Adsyn200과 달리, AdSyn-CO171은 간에 축적되지 않고 대신 다른 기관, 이 경우에는 비-종양을 가진 동물의 비장 및 림프절을 표적으로 할 수 있다(도 22).
E1A, E4orf1 및/또는 E4orf6/7에서 하나 또는 그 이상의 돌연변이를 갖는 E2F 선택성 바이러스의 전신성 전달을 가능하게 하기 위해, 재조합 아데노바이러스는 헥손에서 간을 비표적화하는 E451Q 변형을 추가로 포함하도록 조작되었다(예를 들어, AdSyn-CO335 및 AdSyn-CO442 참조; 도 20 및 21 및 실시예 2 참조).
아데노바이러스 헥손 유전자에 대한 다른 돌연변이는 간에서의 아데노바이러스 축적을 방지하기 위해 본 발명에서 고려된다. 예를 들어, 재조합 아데노바이러스는 헥손의 9개의 초가변영역을 다른 혈청형의 영역으로 대체함으로써 간에서 비표적화될 수 있다.
본 발명은 재조합 아데노바이러스의 게놈이 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 변형된 또는 결실된 E4orf6/7 단백질, 또는 이들의 임의의 조합을 암호화하고, 추가로 변형된 헥손 단백질을 암호화하며, 종양세포와 비교하여 정상세포에서 복제 결함을 나타내는 재조합 아데노바이러스를 제공한다(예를 들어, AdSyn-CO335 참조).
일부 실시예에서, 변형된 헥손 단백질은 E451Q 치환을 포함한다. 특정 실시예에서, 재조합 아데노바이러스의 게놈은 서열번호 30, 서열번호 92 또는 서열번호 97과 적어도 90%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98% 또는 적어도 99% 상동성을 갖거나, 게놈은 서열번호 30, 서열번호 92 또는 서열번호 97의 뉴클레오티드 서열을 포함하거나 상기 서열로 구성된다.
또한, 본 발명은 재조합 아데노바이러스의 게놈이 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 변형된 또는 결실된 E4orf6/7 단백질, 또는 이들의 임의의 조합을 암호화하고, 간 특이적인 마이크로 RNA를 위한 하나 또는 그 이상의 결합부위를 추가로 포함하며, 종양세포와 비교하여 정상세포에서 복제 결함을 나타내는 재조합 아데노바이러스를 제공한다.
일부 실시예에서, 간 특이적인 마이크로 RNA를 위한 하나 또는 그 이상의 결합 부위는 E1A의 3'-UTR에 위치된다. 일부 실시예에서, 간 특이적인 마이크로 RNA는 miR-122, miR-30 또는 miR-192이다.
C. 유도성 재표적화를 위한 변형
본 명세서에 개시된 재조합 아데노바이러스 종양세포 수용체에 대한 생체 내 유도성 재표적화(inducible retargeting)를 위해 추가로 변형될 수 있다. 흔히 사용되는 Ad2/5 벡터는 감염을 위해 상피세포에 존재하지만, 대부분의 전이성 암에는 없는 콕사키 아데노바이러스 수용체(CAR)에 의존한다. "RapAD"는 융합 단백질을 통해 임의의 종양세포 수용체(또는 임의의 세포 유형)로의 아데노바이러스 감염의 라파마이신/라파로그 유도성 표적화를 가능하게 한다(본 명세서에서 전체가 참고 문헌으로 인용되는 PCT 출원번호 WO 2013/138505 참조). 유연한 어댑터 시스템의 사용은 바이러스 캡시드의 조립을 방해하지 않는다. 이상적인 재표적화 융합 단백질은 특정 암세포 표면 분자에 대해 강한 친화성을 갖는 항체이다. 낙타과 및 상어는 단일 10kDa 가변 VHH 도메인을 통해 에피토프를 인식하는 단일-도메인 항체(sdAb)를 암호화한다. 합성생물학을 이용하면 폐암에서 고도로 상향조절된 EGFR 및 CEACAM5와 같은 특정 분자를 인식하는 VHH가 만들어질 수 있다. 라파마이신은 CAR이 하향조절된 전이성 종양세포에서 EGFR에 대한 합성 아데노바이러스 감염을 재표적화한다는 것이 증명되었다.
조작된 아데노바이러스는 생물학적으로 직교하는(orthogonal) 라파로그 AP21967로 표적화될 수 있다. 라파마이신은 종양 살상 아데노바이러스 치료와 합리적인 조합이지만, 라파마이신에 의한 세포 및 유기체의 영향을 피하는 것이 바람직할 수 있는 경우가 있을 수 있다. 따라서, 아데노바이러스 재표적화를 위한 또 다른 옵션으로, 라파마이신의 구조상 동족체인 AP21967이 사용될 수 있다. AP21967은 FKBP 및 돌연변이 FRB* 도메인(mTOR 돌연변이 T2098L)과 안정한 이종이량체를 형성할 수 있지만 야생형 FRB 도메인과는 형성할 수 없다. 라파마이신과 달리, AP21967은 표준 하류 기질인 p70S6 키나아제 인산화에 의해 입증되는 것 처럼, mTOR 신호전달을 불활성화하지 않는다. 그러나 AP21967은 여전히 FKBP-VHH 융합체를 통해 종양세포에 바이러스를 발현하는 FRB*-섬유(FRB-섬유는 제외)의 재표적화를 유도할 수 있다(도 18).
EGFR-표적화된 아데노바이러스가 돌연변이 FRB 도메인(FRB*)과 함께 변형될 때, 이는 라파마이신 및 AP21967과 더불어 EGFR을 통해 세포를 감염시키도록 유도될 수 있다(도 18 내지 21 및 하기 실시예 2 참조).
본 발명은 게놈이 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 변형된 또는 결실된 E4orf6/7 단백질, 또는 이들의 임의의 조합을 암호화하고, FKBP 단백질에 융합된 표적화 리간드를 추가로 암호화하며, 야생형 FRB 단백질 또는 T2098L 치환을 포함하는 돌연변이 FRB 단백질에 융합된 아데노바이러스 섬유단백질을 암호화하는 재조합 아데노바이러스를 제공한다.
일부 실시예에서, 표적화 리간드는 예컨대 낙타과 VHH 항체와 같은 단일 도메인 항체이다. 특정 실시예에서, 단일 도메인 항체는 EGFR, 또는 종양세포에서 상향조절되는 다른 분자에 특이적이다. 비-제한적인 실시예에서, 재조합 아데노바이러스의 게놈은 서열 번호 25, 서열번호 26 또는 서열번호 88에 대해 적어도 90%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98% 또는 적어도 99%의 상동성을 갖거나, 서열번호 25, 서열번호 26 또는 서열번호 88의 뉴클레오티드 서열을 포함하거나 상기 서열로 구성된다(예를 들어, AdSyn-CO312, AdSyn-CO313 및 AdSyn-CO205 참조).
일부 실시예에서, FKBP-표적화 리간드 융합 단백질은 E3-RIDα/RIDβ 및 E3-14.7k 코딩서열을 결실시킴으로써 아데노바이러스 게놈에 수용된다. 그러나, 아데노바이러스 게놈의 다른 위치가 고려된다. 예를 들어, 표적화 리간드-FKBP 융합 단백질은 또한 자가-절단 P2A 링커서열(예를 들어, AdSyn-CO440; 서열번호 68 참조)을 갖는 E3-ADP에 N-말단 융합체 또는 자가-절단 P2A 서열을 갖는 E1B-55k에 C-말단 융합체로서 삽입될 수 있다.
또한, 게놈이 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 변형된 또는 결실된 E4orf6/7 단백질, 또는 이들의 임의의 조합을 암호화하고, 추가로 T2098L 치환을 포함하는 돌연변이 FRB 단백질에 융합된 아데노바이러스 섬유단백질을 암호화하는 재조합 아데노바이러스를 제공한다. 일부 실시예에서, 게놈은 E451Q 치환을 포함하는 변형된 헥손 단백질을 추가로 암호화한다. 특정 실시예에서, 재조합 아데노바이러스의 게놈은 서열번호 31과 적어도 90%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98% 또는 적어도 99% 상동성을 갖거나 서열번호 31의 뉴클레오티드 서열을 포함하거나 상기 서열로 구성된다(예를 들어, AdSyn-CO336 참조).
전술한 유도성 재표적화된 재조합 아데노바이러스는 돌연변이 헥손 단백질(예를 들어, E451Q 치환)과 같은 간 재표적화 변형을 추가로 포함할 수 있다. 택일적으로 또는 추가적으로, 재조합 아데노바이러스의 게놈은 간 특이적인 마이크로 RNA에 대한 하나 또는 그 이상의 결합 부위를 포함할 수 있다(전술한 바와 같다).
D. 재표적화를 위한 키메라 섬유 단백질
Ad5 및 다른 많은 혈청형의 섬유 단백질이 세포 부착을 위해 콕사키 아데노바이러스 수용체(CAR)에 결합하는 것으로 밝혀졌지만, 다른 혈청형은 CD46, 데스모 글레인 2, 시알산 등을 사용하는 것으로 알려져 있다. 따라서, 본 발명에서는 키메라 섬유 단백질을 암호화하는 게놈을 갖는 재조합 아데노바이러스가 제공되고, 이를 통해 재조합 바이러스를 다른 세포 수용체로 표적화한다(도 23A 내지 23E 및 하기 실시예 3 참조).
본 발명은 게놈이 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 변형된 또는 결실된 E4orf6/7 단백질, 또는 이들의 임의의 조합을 암호화하고, 추가로 키메라 섬유 단백질을 암호화하는 재조합 아데노 바이러스를 제공한다.
일부 실시예에서, 키메라 섬유 단백질은 제1 아데노바이러스 혈청형으로부터의 섬유 샤프트(shaft) 및 제2 아데노바이러스 혈청형으로부터의 섬유 노브(knob)를 포함한다. 일부 실시예에서, 제1 아데노바이러스 혈청형은 Ad5이고, 제2 아데노바이러스 혈청형은 Ad3, Ad9, Ad11, Ad12, Ad34 또는 Ad37이다. 하나의 비-제한적인 실시예에서, 제1 아데노바이러스 혈청형은 Ad5이고, 제2 아데노바이러스 혈청형은 Ad34이다.
특정 실시예에서, 재조합 아데노바이러스의 게놈은 서열번호 82, 서열번호 83 또는 서열번호 84의 뉴클레오티드 서열을 포함한다.
키메라 섬유를 발현하는 재조합 종양 살상 아데노바이러스는 전술한 바와 같이 유도성 표적화 및/또는 간 재표적화 변형을 추가로 포함할 수 있다.
E. 중화 항체를 피하기 위한 캡시드 교환
본 발명은 천연 아데노바이러스 모듈화(modularity)를 이용하여 기존의 중화 항체를 피할 수 있는 키메라 바이러스를 생성하는 것을 추가로 고려한다. 특히, 완전한 '캡시드' 모듈 교환(거의 게놈의 60%)을 가지며 기존의 항체에 보이지 않게하고 반복된 접종을 가능하게 하는 Ad5 기반 바이러스가 본 명세서에 개시되어있다. 캡시드 교환된 재조합 아데노바이러스는 실시예 4에 추가로 나타나있다(도 24 내지 도 26 참조).
본 발명은 게놈이 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 변형된 또는 결실된 E4orf6/7 단백질, 또는 이들의 임의의 조합을 암호화하고, 캡시드-교환된 키메라 아데노바이러스를 암호화하는 재조합 아데노바이러스를 제공한다. 일부 실시예에서, 게놈의 E1, E3 및 E4 영역은 제1 아데노바이러스 혈청형으로부터 유도되고 게놈의 E2B, L1, L2, L3, E2A 및 L4 영역은 제2 아데노바이러스 혈청형으로부터 유래된다. 일부 실시예에서, 제1 아데노바이러스 혈청형의 E1 영역은 제2 아데노바이러스 혈청형으로부터의 pIX 단백질을 암호화하도록 변형; 및/또는 제1 아데노바이러스 혈청형의 E3 영역은 제2 아데노바이러스 혈청형으로부터 U엑손 및 섬유 단백질을 암호화하도록 변형된다. 특정 실시예에서, 제1 아데노바이러스 혈청형은 Ad5이고 제2 아데노바이러스 혈청형은 Ad3, Ad9, Ad11, Ad34 또는 Ad37이다.
특정 실시예에서, 재조합 아데노바이러스의 게놈은 서열번호 85의 뉴클레오티드 서열, 또는 서열번호 92 내지 97 중 임의의 어느 하나를 포함한다.
재조합 종양 살상, 캡시드-교환된 아데노바이러스는 상술한 바와 같이 키메라 섬유, 유도성 표적화 및/또는 간 재표적화 변형을 추가로 포함할 수 있다.
F. 다른 변형
본 명세서에 개시된 재조합 아데노바이러스는 또한 종양을 선택적으로 증진시키고, 특정 세포 유형으로의 감염을 지시하고, 존재하는 중화 항체를 피하는 것과 같은 추가의 변형을 포함할 수 있다.
일 실시예에서, 재조합 아데노바이러스는 인테그린-결합 RGD 모티프에서 RGE로의 돌연변이를 갖는 캡시드 단백질 펜톤과 함께 E1, E3, 및 E4 돌연변이를 갖는 EGFR-표적화된 종양 살상 아데노바이러스이다(예를 들어, AdSyn-CO511; 서열번호 86). 상기 펜톤 돌연변이는 비장에서 바이러스 흡수를 감소시키고 항바이러스 염증반응을 약화시키는 것으로 나타났다.
다른 실시예에서, 재조합 종양 살상 아데노바이러스는 섬유 단백질에서 RGD 펩티드의 삽입과 함께 E1 및 E4 돌연변이를 포함한다(예를 들어, AdSyn-CO512; 서열번호 87). 섬유 단백질에서 RGD 삽입은 혈관 내피세포를 포함하는 다양한 종류의 세포로의 감염을 극적으로 증가시키는 것으로 나타났다.
G. 재조합 리포터 아데노바이러스
본 발명은 재조합 리포터 아데노바이러스를 제공한다. 일부 실시예에서, 재조합 아데노바이러스의 게놈은 E1A의 결실을 포함하고 EF1α-루시퍼라제를 암호화한다(예를 들어, AdSyn-CO199, AdSyn-CO200 및 AdSyn-CO171 참조).
일부 실시예에서, 재조합 아데노바이러스의 게놈은 간 특이적인 마이크로 RNA에 대한 하나 또는 그 이상의 결합 부위를 추가로 포함 및/또는 변형된 헥손 단백질을 암호화한다. 일부 실시예에서, 간 특이적인 마이크로 RNA에 대한 하나 또는 그 이상의 결합 부위는 E1A의 3'-UTR에 위치한다. 특정한 비-제한적인 실시예에서, 간 특이적인 마이크로 RNA는 miR-122이다. 일부 실시예에서, 변형된 헥손 단백질은 E451Q 치환을 포함한다.
특정한 비-제한적인 실시예에서, 재조합 아데노바이러스의 게놈은 적어도 90%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98% 또는 적어도 99% 상동성을 갖거나 서열번호 27(AdSyn-CO199), 서열번호 28(AdSyn-CO200), 또는 서열번호 29(AdSyn-CO171)의 뉴클레오티드 서열을 포함하거나 상기 서열로 구성된다.
Ⅳ. 야생형과 돌연변이 바이러스 서열
본 명세서에 개시된 재조합 아데노바이러스의 재조합 아데노바이러스 게놈이 본 발명에 의해 제공된다. 특히, 서열번호 1 내지 31 및 68 내지 98 중 임의의 어느 하나와 적어도 90%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98% 또는 적어도 99% 상동성을 갖는 뉴클레오티드 서열을 포함하는 재조합 핵산 분자가 제공된다. 특정 실시예에서, 재조합 핵산은 서열번호 1 내지 31 및 68 내지 98 중 임의의 어느 하나의 뉴클레오티드 서열을 포함하거나 상기 서열로 구성된다.
또한, 재조합 아데노바이러스 게놈을 포함하는 벡터가 제공된다. 일부 실시예에서, 서열번호 1 내지 31 및 68 내지 98 중 임의의 하나와 적어도 90%, 적어도 95%, 적어도 96%, 적어도 97%, 적어도 98% 또는 적어도 99% 상동성을 갖는 핵산 분자를 포함하는 벡터가 제공된다. 일부 실시예에서, 서열번호 1 내지 31 및 68 내지 98 중 임의의 어느 하나의 뉴클레오티드 서열을 포함하거나 상기 서열로 구성된 핵산 분자를 포함하는 벡터가 제공된다.
하기에 개시된 재조합 아데노바이러스에 의해 발현되는 야생형 및 돌연변이 아데노바이러스 단백질 서열이 제공된다.
E1A 돌연변이
하기 E1A 서열에서 LXCXE 모티프는 밑줄로 표시된다. 이 모티프는 Ad5 E1A(서열번호 32)의 아미노산 122 내지 126에 존재한다. Y47H 및 C124G 치환은 굵게 표시하였다.
Ad5 E1A
MRHIICHGGVITEEMAASLLDQLIEEVLADNLPPPSHFEPPTLHELYDLDVTAPEDPNEEAVSQIFPDSVMLAVQEGIDLLTFPPAPGSPEPPHLSRQPEQPEQRALGPVSMPNLVPEVIDLTCHEAGFPPSDDEDEEGEEFVLDYVEHPGHGCRSCHYHRRNTGDPDIMCSLCYMRTCGMFVYSPVSEPEPEPEPEPEPARPTRRPKMAPAILRRPTSPVSRECNSSTDSCDSGPSNTPPEIHPVVPLCPIKPVAVRVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP(서열번호 32)
Ad5 E1A △LXCXE
MRHIICHGGVITEEMAASLLDQLIEEVLADNLPPPSHFEPPTLHELYDLDVTAPEDPNEEAVSQIFPDSVMLAVQEGIDLLTFPPAPGSPEPPHLSRQPEQPEQRALGPVSMPNLVPEVIDAGFPPSDDEDEEGEEFVLDYVEHPGHGCRSCHYHRRNTGDPDIMCSLCYMRTCGMFVYSPVSEPEPEPEPEPEPARPTRRPKMAPAILRRPTSPVSRECNSSTDSCDSGPSNTPPEIHPVVPLCPIKPVAVRVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP(서열번호 33)
Ad5 E1A C124G
MRHIICHGGVITEEMAASLLDQLIEEVLADNLPPPSHFEPPTLHELYDLDVTAPEDPNEEAVSQIFPDSVMLAVQEGIDLLTFPPAPGSPEPPHLSRQPEQPEQRALGPVSMPNLVPEVIDLT G HEAGFPPSDDEDEEGEEFVLDYVEHPGHGCRSCHYHRRNTGDPDIMCSLCYMRTCGMFVYSPVSEPEPEPEPEPEPARPTRRPKMAPAILRRPTSPVSRECNSSTDSCDSGPSNTPPEIHPVVPLCPIKPVAVRVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP(서열번호 34)
Ad5 E1A △2-11
MEEMAASLLDQLIEEVLADNLPPPSHFEPPTLHELYDLDVTAPEDPNEEAVSQIFPDSVMLAVQEGIDLLTFPPAPGSPEPPHLSRQPEQPEQRALGPVSMPNLVPEVIDLTCHEAGFPPSDDEDEEGEEFVLDYVEHPGHGCRSCHYHRRNTGDPDIMCSLCYMRTCGMFVYSPVSEPEPEPEPEPEPARPTRRPKMAPAILRRPTSPVSRECNSSTDSCDSGPSNTPPEIHPVVPLCPIKPVAVRVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP(서열번호 35)
Ad5 E1A Y47H C124G
MRHIICHGGVITEEMAASLLDQLIEEVLADNLPPPSHFEPPTLHELHDLDVTAPEDPNEEAVSQIFPDSVMLAVQEGIDLLTFPPAPGSPEPPHLSRQPEQPEQRALGPVSMPNLVPEVIDLT G HEAGFPPSDDEDEEGEEFVLDYVEHPGHGCRSCHYHRRNTGDPDIMCSLCYMRTCGMFVYSPVSEPEPEPEPEPEPARPTRRPKMAPAILRRPTSPVSRECNSSTDSCDSGPSNTPPEIHPVVPLCPIKPVAVRVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP(서열번호 36)
Ad5 E1A △2-11 Y47H C124G
MEEMAASLLDQLIEEVLADNLPPPSHFEPPTLHELHDLDVTAPEDPNEEAVSQIFPDSVMLAVQEGIDLLTFPPAPGSPEPPHLSRQPEQPEQRALGPVSMPNLVPEVIDLT G HEAGFPPSDDEDEEGEEFVLDYVEHPGHGCRSCHYHRRNTGDPDIMCSLCYMRTCGMFVYSPVSEPEPEPEPEPEPARPTRRPKMAPAILRRPTSPVSRECNSSTDSCDSGPSNTPPEIHPVVPLCPIKPVAVRVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP(서열번호 37)
Ad5 E4orf1 및 E4orf6/7
Ad5 E4orf1의 C-말단(서열번호 38의 126 내지 128 잔기)에서 PDZ-결합 모티프는 밑줄로 표시된다.
Ad5 E4orf1
MAAAVEALYVVLEREGAILPRQEGFSGVYVFFSPINFVIPPMGAV㎖SLRLRVCIPPGYFGRFLALTDVNQPDVFTESYIMTPDMTEELSVVLFNHGDQFFYGHAGMAVVRL㎖IRVVFPVVRQASNV(서열번호 38)
Ad5 E4orf1 △ PDZb
MAAAVEALYVVLEREGAILPRQEGFSGVYVFFSPINFVIPPMGAV㎖SLRLRVCIPPGYFGRFLALTDVNQPDVFTESYIMTPDMTEELSVVLFNHGDQFFYGHAGMAVVRL㎖IRVVFPVVRQA(서열번호 39)
Ad5 E4orf6 /7
MTTSGVPFGMTLRPTRSRLSRRTPYSRDRLPPFETETRATILEDHPLLPECNTLTMHNAWTSPSPPV
KQPQVGQQPVAQQLDSDMNLSELPGEFINITDERLARQETVWNITPKNMSVTHDMMLFKASRGERTVYSVCWEG
GGRLNTRVL(서열번호 40)
E2F와의 결합을 제거 또는 손상시키거나, 핵 위치 신호를 결실시키거나 손상시키는 변형된 E4orf6/7 단백질을 암호화하는 게놈을 갖는 재조합 아데노바이러스가 본 발명에서 고려된다. 일부 실시예에서, 변형된 E4orf6/7 단백질은 E2F 결합 부위를 결실/손상시키기 위해 C-말단에 약 60개, 약 50개, 약 40개, 약 30개, 약 20개 또는 약 10개 아미노산의 결실을 포함한다. 다른 실시예에서, E4orf6/7 단백질은 C-말단 10개의 아미노산에서 결실, 틀이동(frameshift) 또는 삽입, 또는 E2F 결합을 제거하거나 손상시키는 단백질의 C-말단 세번째로부터 33개 아미노산의 결실을 포함한다. 일부 실시예에서, 돌연변이는 E2F 상호작용을 손상시키는 81 내지 91개의 아미노산을 포함한다.
다른 실시예에서, 변형된 E4orf6/7 단백질은 E2F4의 효율적인 전좌를 위해 필요한 핵 위치 서열을 제거하기 위해 58개 아미노산의 N-말단 결실을 포함한다. Ad2 및 Ad5 E4orf6/7의 13 및 38번째 아미노산 사이에는 8개의 아르기닌 잔기가 있으며, 이는 이 영역에 대해 25% 이상의 아르기닌 함량을 가진 것과 동일하다. E4orf6의 N-말단에 있는 아르기닌 잔기의 전체 클러스터링은 다른 아데노바이러스 혈청형에서 유지된다. 알라닌(또는 이 영역을 통해 핵 위치를 제거하기 위한 다른 적절한 잔기)에 대해 16, 18, 21, 22, 27 및/또는 29 아르기닌 잔기를 치환하는 돌연변이가 고려된다.
다른 실시예에서, 변형된 E4orf6/7 단백질은 E2F 이중 부위 점유를 유도하기위한 E4orf6/7의 능력을 제거 또는 저해하기 위한 하나 또는 그 이상의 변형을 포함한다. 특정한 비-제한적인 실시예에서, 프롤린, 알라닌, 리신, 아스파르트산 또는 글루탐산에 대한 F125의 돌연변이; 또는 P, A, K, R, G, F에 대한 D121의 돌연변이를 포함한다.
다른 E4orf6/7 돌연변이는 T133A, R101A, Q105P 또는 E2F 단일 부위 점유를 막는 임의의 돌연변이; 알파나선을 파괴하고 E2F 결합을 막는 M84N 또는 P, G, K, L, H 및/또는 E93A, 또는 K, P, G, R, L, M을 포함한다. 고려되는 다른 돌연변이는 T133Q 또는 A, K, G, P, L, H; G141L, P, K, H, F, A; 또는 V149N, K, P, H, G, E, D를 포함한다.
섬유 서열
하기 재조합 섬유 서열에서, FRB 서열은 밑줄로 표시된다. FRB*에 있는 돌연변이는 굵게 표시된다.
Ad5 섬유
MKRARPSEDTFNPVYPYDTETGPPTVPFLTPPFVSPNGFQESPPGVLSLRLSEPLVTSNGMLALKMGNGLSLDEAGNLTSQNVTTVSPPLKKTKSNINLEISAPLTVTSEALTVAAAAPLMVAGNTLTMQSQAPLTVHDSKLSIATQGPLTVSEGKLALQTSGPLTTTDSSTLTITASPPLTTATGSLGIDLKEPIYTQNGKLGLKYGAPLHVTDDLNTLTVATGPGVTINNTSLQTKVTGALGFDSQGNMQLNVAGGLRIDSQNRRLILDVSYPFDAQNQLNLRLGQGPLFINSAHNLDINYNKGLYLFTASNNSKKLEVNLSTAKGLMFDATAIAINAGDGLEFGSPNAPNTNPLKTKIGHGLEFDSNKAMVPKLGTGLSFDSTGAITVGNKNNDKLTLWTTPAPSPNCRLNAEKDAKLTLVLTKCGSQILATVSVLAVKGSLAPISGTVQSAHLIIRFDENGVLLNNSFLDPEYWNFRNGDLTEGTAYTNAVGFMPNLSAYPKSHGKTAKSNIVSQVYLNGDKTKPVTLTITLNGTQETGDTTPSAYSMSFSWDWSGHNYINEIFATSSYTFSYIAQE(서열번호 41)
Ad5 FRB-섬유
MKRARPSEDTFNPVYPYDTETGPPTVPFLTPPFVSPNGFQESPPGVLSLRLSEPLVTSNGMLALKMGNGLSLDEAGNLTSQNVTTVSPPLKKTKSNINLEISAPLTVTSEALTVAAAAPLMVAGNTLTMQSQAPLTVHDSKLSIATQGPLTVSEGKLALQTSGPLTTTDSSTLTITASPPLTTATGSLGIDLKEPIYTQNGKLGLKYGAPLHVTDDLNTLTVATGPGVTINNTSLQTKVTGALGFDSQGNMQLNVAGGLRIDSQNRRLILDVSYPFDAQNQLNLRLGQGPLFINSAHNLDINYNKGLYLFTASNNSKKLEVNLSTAKGLMFDATAIAINAGDGLEFGSPNAPNTNPLKTKIGHGLEFDSNKAMVPKLGTGLSFDSTGAITVGNKNNDKLTLWTTPAPSPNCRLNAEKDAKLTLVLTKCGSQILATVSVLAVKGSLAPISGTVQSAHLIIRFDENGVLLNNSFLDPEYWNFRNGDLTEGTAYTNAVGFMPNLSAYPKSHGKTAKSNIVSQVYLNGDKTKPVTLTITLNGTQETGDTTEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQPSAYSMSFSWDWSGHNYINEIFATSSYTFSYIAQE(서열번호 42)
Ad5 FRB * -섬유
MKRARPSEDTFNPVYPYDTETGPPTVPFLTPPFVSPNGFQESPPGVLSLRLSEPLVTSNGMLALKMGNGLSLDEAGNLTSQNVTTVSPPLKKTKSNINLEISAPLTVTSEALTVAAAAPLMVAGNTLTMQSQAPLTVHDSKLSIATQGPLTVSEGKLALQTSGPLTTTDSSTLTITASPPLTTATGSLGIDLKEPIYTQNGKLGLKYGAPLHVTDDLNTLTVATGPGVTINNTSLQTKVTGALGFDSQGNMQLNVAGGLRIDSQNRRLILDVSYPFDAQNQLNLRLGQGPLFINSAHNLDINYNKGLYLFTASNNSKKLEVNLSTAKGLMFDATAIAINAGDGLEFGSPNAPNTNPLKTKIGHGLEFDSNKAMVPKLGTGLSFDSTGAITVGNKNNDKLTLWTTPAPSPNCRLNAEKDAKLTLVLTKCGSQILATVSVLAVKGSLAPISGTVQSAHLIIRFDENGVLLNNSFLDPEYWNFRNGDLTEGTAYTNAVGFMPNLSAYPKSHGKTAKSNIVSQVYLNGDKTKPVTLTITLNGTQETGDTTEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDL L QAWDLYYHVFRRISKQPSAYSMSFSWDWSGHNYINEIFATSSYTFSYIAQE(서열번호 43)
표적화 리간드 서열
EGFRVHH-GS-FKBP
MAVQLVESGGGSVQAGGSLRLTCAASGRTSRSYGMGWFRQAPGKEREFVSGISWRGDSTGYADSVKGRFTISRDNAKNTVDLQMNSLRPEDTAIYYCAAAAGSTWYGTLYEYDYWGQGTQVTVSSGSGSGSTGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKL(서열번호 44; FKBP12 서열은 밑줄로 표시된다)
헥손 서열
Ad5 헥손
MATPSMMPQWSYMHISGQDASEYLSPGLVQFARATETYFSLNNKFRNPTVAPTHDVTTDRSQRLTLRFIPVDREDTAYSYKARFTLAVGDNRVLDMASTYFDIRGVLDRGPTFKPYSGTAYNALAPKGAPNPCEWDEAATALEINLEEEDDDNEDEVDEQAEQQKTHVFGQAPYSGINITKEGIQIGVEGQTPKYADKTFQPEPQIGESQWYETEINHAAGRVLKKTTPMKPCYGSYAKPTNENGGQGILVKQQNGKLESQVEMQFFSTTEATAGNGDNLTPKVVLYSEDVDIETPDTHISYMPTIKEGNSRELMGQQSMPNRPNYIAFRDNFIGLMYYNSTGNMGVLAGQASQLNAVVDLQDRNTELSYQLLLDSIGDRTRYFSMWNQAVDSYDPDVRIIENHGTEDELPNYCFPLGGVINTETLTKVKPKTGQENGWEKDATEFSDKNEIRVGNNFAMEINLNANLWRNFLYSNIALYLPDKLKYSPSNVKISDNPNTYDYMNKRVVAPGLVDCYINLGARWSLDYMDNVNPFNHHRNAGLRYRSMLLGNGRYVPFHIQVPQKFFAIKNLLLLPGSYTYEWNFRKDVNMVLQSSLGNDLRVDGASIKFDSICLYATFFPMAHNTASTLEAMLRNDTNDQSFNDYLSAANMLYPIPANATNVPISIPSRNWAAFRGWAFTRLKTKETPSLGSGYDPYYTYSGSIPYLDGTFYLNHTFKKVAITFDSSVSWPGNDRLLTPNEFEIKRSVDGEGYNVAQCNMTKDWFLVQMLANYNIGYQGFYIPESYKDRMYSFFRNFQPMSRQVVDDTKYKDYQQVGILHQHNNSGFVGYLAPTMREGQAYPANFPYPLIGKTAVDSITQKKFLCDRTLWRIPFSSNFMSMGALTDLGQNLLYANSAHALDMTFEVDPMDEPTLLYVLFEVFDVVRVHRPHRGVIETVYLRTPFSAGNATT(서열번호 45)
Ad5 헥손 E451Q
MATPSMMPQWSYMHISGQDASEYLSPGLVQFARATETYFSLNNKFRNPTVAPTHDVTTDRSQRLTLRFIPVDREDTAYSYKARFTLAVGDNRVLDMASTYFDIRGVLDRGPTFKPYSGTAYNALAPKGAPNPCEWDEAATALEINLEEEDDDNEDEVDEQAEQQKTHVFGQAPYSGINITKEGIQIGVEGQTPKYADKTFQPEPQIGESQWYETEINHAAGRVLKKTTPMKPCYGSYAKPTNENGGQGILVKQQNGKLESQVEMQFFSTTEATAGNGDNLTPKVVLYSEDVDIETPDTHISYMPTIKEGNSRELMGQQSMPNRPNYIAFRDNFIGLMYYNSTGNMGVLAGQASQLNAVVDLQDRNTELSYQLLLDSIGDRTRYFSMWNQAVDSYDPDVRIIENHGTEDELPNYCFPLGGVINTETLTKVKPKTGQENGWEKDATEFSDKN Q IRVGNNFAMEINLNANLWRNFLYSNIALYLPDKLKYSPSNVKISDNPNTYDYMNKRVVAPGLVDCYINLGARWSLDYMDNVNPFNHHRNAGLRYRSMLLGNGRYVPFHIQVPQKFFAIKNLLLLPGSYTYEWNFRKDVNMVLQSSLGNDLRVDGASIKFDSICLYATFFPMAHNTASTLEAMLRNDTNDQSFNDYLSAANMLYPIPANATNVPISIPSRNWAAFRGWAFTRLKTKETPSLGSGYDPYYTYSGSIPYLDGTFYLNHTFKKVAITFDSSVSWPGNDRLLTPNEFEIKRSVDGEGYNVAQCNMTKDWFLVQMLANYNIGYQGFYIPESYKDRMYSFFRNFQPMSRQVVDDTKYKDYQQVGILHQHNNSGFVGYLAPTMREGQAYPANFPYPLIGKTAVDSITQKKFLCDRTLWRIPFSSNFMSMGALTDLGQNLLYANSAHALDMTFEVDPMDEPTLLYVLFEVFDVVRVHRPHRGVIETVYLRTPFSAGNATT(서열번호 46; E451Q 치환은 굵게 표시된다)
E3 서열
Ad5 E3-RIDα
MIPRVFILLTLVALFCACSTLAAVSHIEVDCIPAFTVYLLYGFVTLTLICSLITVVIAFIQCIDWVCVRFAYLRHHPQYRDRTIAELLRIL(서열번호 65)
Ad5 E3- RIDβ
MKFTVTFLLIICTLSAFCSPTSKPQRHISCRFTRIWNIPSCYNEKSDLSEAWLYAIISVMVFCSTILALAIYPYLDIGWNAIDAMNHPTFPAPA㎖PLQQVVAGGFVPANQPRPPSPTPTEISYFNLTGGDD(서열번호 66)
Ad5 E3-14.7K
MTDTLDLEMDGIITEQRLLERRRAAAEQQRMNQELQDMVNLHQCKRGIFCLVKQAKVTYDSNTTGHR
LSYKLPTKRQKLVVMVGEKPITITQHSVETEGCIHSPCQGPEDLCTLIKTLCGLKDLIPFN(서열번호 67)
Ⅴ. 약학적 조성물
본 발명은 재조합 아데노바이러스(또는 재조합 아데노바이러스를 암호화하는 하나 또는 그 이상의 핵산 또는 벡터)를 포함하는 조성물을 제공한다. 상기 조성물은 시험관내 또는 생체내에서의 임의의 제형 및 투여에 적합하다. 선택적으로, 조성물은 제공된 제제 및 약학적으로 허용가능한 담체 중 하나 또는 그 이상을 포함한다. 적합한 담체 및 이의 제형은 Remington : The Science and Practice of Pharmacy, 22 nd Edition, Loyd V. Allen et al., editors, Pharmaceutical Press(2012)에 기재되어있다. 약학적으로 허용가능한 담체는 생물학적으로 또는 다른 방식으로 바람직하지 않은 물질을 포함하지 않는다. 즉, 물질은 바람직하지 않은 생물학적 효과를 일으키지 않거나 포함되어 있는 제약 조성물의 다른 성분과 유해한 방식으로 상호작용하지 않고 개체에게 투여된다. 개체에게 투여되는 경우, 담체는 활성성분의 분해를 최소화하고 개체에서의 부작용을 최소화하도록 임의로 선택된다.
재조합 바이러스(또는 재조합 아데노 바이러스를 암호화하는 하나 또는 그 이상의 핵산 또는 벡터)는 정맥내 투여, 예를 들어 볼루스(bolus)와 같은 공지된 방법에 따라, 또는 일정 기간에 걸친 연속적인 주입에 의해, 근육내, 복강내, 뇌척수내, 피하, 관절내, 활액막내, 척추강내, 구강, 국소, 종양내 또는 흡입경로로 투여될 수 있다. 투여는 국소적이거나 전신적일 수 있다. 조성물은 국소적인 투여, 경구 투여, 비경구 투여, 정맥내 투여, 관절내 투여, 복강내 투여, 근육내 투여, 피하 투여, 병변내 투여, 경피 투여, 간내 투여, 두개내 투여를 포함하는 임의의 여러가지 투여 방법, 분무/흡입, 또는 기관지 내시경을 통한 설치에 의해 투여될 수 있다. 따라서, 조성물은 국소적인 치료 또는 전신적인 치료가 바람직한지의 여부 및 치료될 영역에 따라 여러가지 방법으로 투여된다.
일부 실시예에서, 투여를 위한 조성물은 약학적으로 허용가능한 담체, 바람직하게는 수성 담체에 용해된 본 명세서에 기재된 재조합 아데노바이러스(또는 재조합 게놈)를 포함할 것이다. 다양한 수성 담체, 예를 들어 완충 식염수 등이 사용될 수 있다. 이러한 용액은 멸균 처리되어 있으며, 일반적으로 바람직하지 않은 물질이 없다. 이러한 조성물은 통상의 잘 알려진 멸균 기술에 의해 멸균될 수 있다. 조성물은 예를 들어, 아세트산나트륨, 염화나트륨, 염화칼륨, 염화칼슘, 락트산나트륨 등과 같은 pH 조절제 및 완충제, 독성 조절제 등과 같은 생리적인 조건을 유사하게 하는데 필요한 약학적으로 허용가능한 보조물질을 함유할 수 있다. 이들 중활성제제의 농도는 다양할 수 있으며, 선택된 특정 투여방식 및 대상의 요구에 따라 주로 체액의 부피, 점도, 체중 등에 기초하여 선택될 것 이다.
약학적 제형, 특히 재조합 바이러스의 약학적 배합물은 원하는 순도를 갖는 재조합 아데노바이러스(또는 재조합 아데노바이러스를 암호화하는 하나 또는 그 이상의 핵산)를 임의의 약학적으로 허용가능한 담체, 부형제 또는 안정화제와 혼합함으로써 제조될 수 있다. 이러한 제형은 동결건조된 제형 또는 수용액일 수 있다.
허용가능한 담체, 부형제, 또는 안정화제는 사용된 용량과 농도가 수혜자에게 독성을 나타내지 않는다. 허용가능한 담체, 부형제, 또는 안정화제는 아세트산염, 인산염, 시트르산염, 및 기타 유기산; 항산화제(예를 들어, 아스코르브산)방부제, 저분자량 폴리펩티드; 혈청 알부민 또는 젤라틴과 같은 단백질, 또는 폴리비닐피롤리돈과 같은 친수성 중합체; 및 글루코스, 만노오스, 또는 덱스트린을 포함하는 아미노산, 단당류, 이당류, 및 다른 탄수화물; 킬레이트제; 및 이온성 및 비이온성 계면활성제(예를 들어, 폴리소르베이트); 나트륨과 같은 염-형성 반대-이온; 금속착물(예를 들어, Zn-단백질 복합체); 및/또는 비이온성 계면활성제일 수 있다. 재조합 아데노바이러스(또는 재조합 아데노바이러스를 암호화하는 하나 또는 그 이상의 핵산)는 임의의 적절한 농도의 감염 단위로 제형화될 수 있다.
경구 투여에 적합한 제형은 (a) 물, 식염수 또는 PEG 400과 같은 희석제에 현탁된 재조합 아데노바이러스의 유효량과 같은 액체 용액; (b) 각각 미리 결정된 양의 활성성분을 액체, 고형물, 과립 또는 젤라틴으로서 포함하는 캡슐, 봉지 또는 정제; (c) 적합한 액체에서의 현탁액; 및 (d) 적합한 에멀젼으로 구성될 수 있다. 정제 형태는 하나 또는 그 이상의 락토오스, 수크로오스, 만니톨, 솔비톨, 인산칼슘, 옥수수전분, 감자전분, 결정셀룰로오스(microcrystalline cellulose), 젤라틴, 콜로이드성 이산화규소, 활석, 마그네슘 스테아레이트, 스테아르산, 및 기타 부형제, 착색제, 충전제, 결합제, 희석제, 완충제, 습윤제, 방부제, 향료, 염료, 붕해제, 및 약학적으로 호환성이 있는 담체를 포함할 수 있다. 사탕 형태는 예를 들어, 수크로오스뿐만 아니라 젤라틴 및 글리세린 또는 수크로오스 및 아카시아 에멀젼, 젤 등과 같은 비활성 염기에 활성성분을 포함하는 사탕과 같은 활성성분을 항료내에 포함할 수 있으며, 추가로 활성성분, 당분야에 공지된 담체를 포함할 수 있다.
단독으로 또는 다른 적합한 성분과 조합된 재조합 아데노바이러스(또는 재조합 아데노바이러스를 암호화하는 하나 또는 그 이상의 핵산)는 흡입을 통해 투여될 수 있는 에어로졸 제형으로 제조될 수 있다(즉, 이들은 "분무될 수 있다"). 에어로졸 제형은 디클로로디플루오로메탄, 프로판, 질소 등과 같은 가압된 허용가능한 추진제에 배치될 수 있다.
예를 들어, 관절내(관절내), 정맥내, 근육내, 종양내, 피내, 복강내 및 피하 경로와 같은 비경구 투여에 적합한 제형은 항산화제, 완충제, 정균제, 및 제형을 의도된 수용자의 혈액과 등장성으로 만드는 용액을 포함할 수 있는 수성 및 비수성의 등장성 멸균 주사 용액, 및 현탁제, 용해제, 증점제, 안정화제 및 방부제를 포함할 수 있는 수성 및 비수성 멸균 현탁액을 포함한다. 제공된 방법에서, 조성물은, 예를 들면, 정맥 내 주입, 경구적으로, 국소적으로, 복강 내(intraperitoneally), 방광내(intravesically), 종양내(intratumorally), 또는 척수강내(intrathecally)로 투여될 수 있다. 비경구용 투여, 종양내 투여, 및 정맥 내 투여는 투여의 바람직한 방법이다. 화합물의 제형은 앰플 및 바이알과 같은, 단위-용량 또는 다중-용량의 봉인된 용기에서 존재할 수 있다.
주사 용액 및 현탁액은 이전에 설명된 종류의 멸균 분말, 과립제, 및 정제로부터 제조될 수 있다. 생체 외 치료를 위해 아데노바이러스에 의해 형질도입 또는 감염되거나 또는 핵산으로 형질감염된 세포는 상기에서 설명된 바와 같이 정맥 내 또는 비경구용으로 투여될 수 있다.
약학적 제제는 바람직하게는 단위 복용량(unit dosage) 형태이다. 이러한 형태에서 제제는 유효 성분의 적절한 용량을 포함하는 단위 용량(unit dose)으로 세분화된다. 따라서, 약학적 조성물은 투여 방법에 의존하는 다양한 단위 복용량 형태로 투여될 수 있다. 예를 들면, 경구 투여에 적절한 단위 복용량 형태는 분말, 정제, 환제, 캡슐 및 캔디를 포함하나, 이에 한정하지 않는다.
일부 실시예에서, 조성물은 다른 세포내 수용체에 결합하는 재조합 아데노바이러스와 같은, 적어도 2개의 다른 재조합 아데노바이러스를 포함한다. 예를 들면, 조성물에서 재조합 아데노바이러스의 적어도 하나는 키메라 섬유 단백질을 발현할 수 있다. 대안적으로, 재조합 아데노바이러스는 조성물 내의 바이러스 간의 상이한 표적 리간드와 FKBP 융합 단백질을 암호화하여 다른 세포내 수용체를 표적화할 수 있다. 일부 실시예에서, 조성물은 2개, 3개, 4개, 5개 또는 6개의 다른 재조합 아데노바이러스를 포함한다.
Ⅵ. 치료 방법
본 명세서에 개시된 재조합 아데노바이러스 조성물은 치료적 또는 예방적 치료에 투여될 수 있다. 특히, 개체에서 종양 세포 생존능을 저해하는, 개체에서 종양 진행을 저해하는, 개체에서 종양 부피를 감소하는 및/또는 개체에서 암을 치료하는 방법을 제공한다. 상기 방법은 개체에게 재조합 아데노바이러스(또는 이의 조성물)의 치료학적 유효량의 투여를 포함한다. 전문에 걸쳐 설명된 바와 같이, 아데노바이러스 또는 약학적 조성물은 정맥 내, 혈관 내, 척수강 내, 근육 내, 피하 내, 복강 내(intraperitoneally), 또는 경구를 포함하는 여러 가지 방법으로 투여되나, 제한되지 않는다. 선택적으로, 상기 방법은 개체에게 하나 이상의 추가 치료제를 투여하는 것을 포함한다. 일부 실시예에서, 상기 치료제는 화학치료제이다. 다른 실시예에서, 치료제는 면역 조절제이다. 또 다른 실시예에서, 치료제는 CDK 4 저해제와 같은, CDK 저해제이다.
일부 실시예에서, 암 또는 종양은 폐, 전립선, 직장(colorectal), 유방, 갑상선, 신장, 또는 간의 암 또는 종양이거나, 또는 백혈병 유형이다. 일부 경우에서, 암은 전이성이다. 일부 실시예에서, 종양은 유방, 뇌하수체(pituitary), 갑상선, 또는 전립샘(prostate gland); 뇌, 간, 뇌척수막, 골, 난소, 자궁, 또는 자궁경부의 종양; 단핵구성 또는 골수성 백혈병; 선암, 샘종(adenoma), 별아교세포종(astrocytoma), 방광종양(bladder tumor), 뇌종양, 버킷림프종(Burkitt’s lymphoma), 유방암종, 경부암종, 결장암종, 신장암종, 간 암종, 폐 암종, 난소 암종, 췌장 암종(pancreatic carcinoma), 전립선 암종, 직장 암종, 피부 암종, 위암종, 고환암종, 갑상선 암종, 연골육종, 융모암, 섬유종, 섬유육종, 교모세포종, 신경교종, 간세포암, 조직구종(histiocytoma), 평활세포근모종(leiomyoblastoma), 평활근육종, 림프종, 지방육종 세포, 유방 종양, 수모세포종, 골수종(myeloma), 형질세포종(plasmacytoma), 신경아세포종, 신경교종(neuroglioma), 골육종(osteogenic sarcoma), 췌장종양(pancreatic tumor), 뇌하수체 종양(pituitary tumor), 망막아세포종, 횡문근육종, 육종(sarcoma), 고환종양, 가슴샘종(thymoma), 또는 윌름스종양(Wilms tumor)이다. 종양은 뇌, 신경, 눈, 및 뇌척수막(별아교세포종(astrocytomas), 신경교종, 교모세포종, 망막아세포종, 신경종(neuromas), 신경아세포종, 신경초종(Schwannomas), 및 수막종(meningiomas)을 포함하여)의 혈관종(hemangiomas), 흑색종, 육종(카포시 육종(Kaposi's sarcoma)뿐만 아니라 골 및 연조직으로부터 발생하는 것을 포함하여) 및 종양뿐만 아니라, 유방, 결장, 직장(rectum), 폐, 구강인두(oropharynx), 후두인두(hypopharynx), 식도(esophagus), 위(stomach), 췌장(pancreas), 간, 쓸개(gallbladder) 및 쓸개관(bile ducts), 소장(small intestine), 요로(urinary tract)(신장, 방광 및 요로상피를 포함하여), 여성생식관(암컷 genital tract), (자궁경부, 자궁, 및 난소 뿐만 아니라 융모암 및 임신영양막병(gestational trophoblastic)을 포함하여), 남성생식관(전립선, 정낭(seminal vesicles), 고환 및 생식 세포 종양을 포함하는), 내분비샘(endocrine glands)(갑상선, 부신(adrenal), 및 뇌하수체(pituitary glands)를 포함하는), 및 피부의 암종(carcinoma)을 포함하는 원발 및 전이성 고형종양 모두를 포함한다. 일부 측면에서, 림프종(호지킨(Hodgkin's) 및 비-호지킨 림프종 모두)의 치료에서 뿐만 아니라 백혈병과 같은 혈액암(hematopoietic malignancies)(즉, 녹색증(chloromas), 형질세포종(plasmacytomas) 및 균상 식육종(mycosis fungoides) 및 피부 T-세포 림프종/백혈병의 플라크 및 종양)으로부터 발생하는 고형종양은 치료될 수 있다. 추가적으로, 치료제는 본 명세서에서 설명된 종양으로부터의 전이 방지에 사용할 수 있다.
치료적 적용에서, 재조합 아데노바이러스 또는 이의 조성물을 개체에게 치료학적 유효량 또는 용량을 투여할 수 있다. 상기 사용을 위한 유효량은 질병의 심각성 및 환자 건강의 통상적인 상태에 의존할 것이다. 조성물의 단일 또는 다중 투여는 환자의 필요성 및 내약성에 따라 복용량 및 빈도에 의존적으로 투여될 수 있다. “환자” 또는 “개체”는 인간 및 다른 동물, 특히 포유동물 모두를 포함한다. 따라서, 상기 방법은 인간 치료 및 수의학 적용 모두에 적용 가능하다.
변형된 서열을 가지는 아데노바이러스의 유효량은 각 게체별로 결정되고, 적어도 부분적으로, 사용된 특정한 재조합 아데노바이러스에 기반한다; 개인의 크기, 연령, 성별; 및 증식 세포의 크기 및 다른 특성. 예를 들면, 인간 치료를 위하여, 재조합 바이러스의 적어도 103 (플라크 형성단위(plaque forming units, PFU))가 사용되고, 예를 들면, 적어도 104, 적어도 105, 적어도 106, 적어도 107, 적어도 108, 적어도 109, 적어도 1010, 적어도 1011, 또는 적어도 1012 PFU 바이러스가 사용되고, 예를 들면 증식 세포의 유형, 크기 및 수 또는 신생물(neoplasm)의 존재에 의존하여 재조합 바이러스의 대략 103 내지 1012 PFU가 사용된다. 유효량은 약 1.0 pfu/kg 체중부터 약 1015 pfu/kg 체중까지(예를 들어, 약 102 pfu/kg 체중부터 약 1013 pfu/kg 체중까지)일 수 있다. 재조합 아데노바이러스는 단일 용량 또는 다중 용량(예를 들어, 2, 3, 4, 6, 또는 그 이상의 용량)으로 투여될 수 있다. 다중 용량은 동시에 또는 연속적으로(예를 들어, 일 또는 주(weeks)의 기간에 걸쳐) 투여될 수 있다.
일부 실시예에서, 상기 제공된 방법은 개체에게 항암제 또는 다른 치료적 처치(종양의 외과 절제와 같은)와 같은, 하나 이상의 추가 치료제를 투여하는 것을 포함한다. 대표적인 항암제들은 유사분열 저해제(mitotic inhibitor), 알킬화제, 항-대사물질, 삽입성 항생제, 성장 인자 저해제, 세포주기 저해제, 효소, 국소이성화효소(topoisomerase) 저해제, 항-생존제, 생물학적 반응조절제, 항-호르몬(예를 들어 항-안드로겐(항-androgens)), 항혈관생성 제 및 CDK 저해제와 같은, 화학치료제를 포함하나, 이에 한정되지 않는다. 다른 항암치료는 방사선 치료 및 암세포를 특이적으로 표적하는 다른 항체를 포함한다.
알킬화제의 비제한적인 예들은 질소 머스타드(nitrogen mustards)(메클로르에타민(mechlorethamine), 사이클로포스포아마이드, 멜팔란(melphalan), 우라실 머스타드(uracil mustard) 또는 클로람부실(chlorambucil)과 같은), 알킬 설포네이트(alkyl sulfonates)(부설판(Busulfan)과 같은), 니트로소우레아(nitrosoureas)(카르무스틴(carmustine), 로무스틴(lomustine), 세무스틴(semustine), 스트렙토조신(streptozocin), 또는 다카바진(dacarbazine)과 같은)를 포함한다.
항대사물질의 비제한적인 예들은 엽산 유사체 (메토트렉사트(methotrexate)와 같은), 피리미딘(pyrimidine) 유사체(5-FU 또는 시타라빈(cytarabine)과 같은), 및 머캅토퓨린(mercaptopurine) 또는 티오구아닌(thioguanine)과 같은 퓨린(purine) 유사체를 포함한다.
천연물의 비제한적인 예들은 빈카 알칼로이드(vinca alkaloids)(빈블라스틴(vinblastine), 비크리스틴(vincristine) 또는 빈데신(vindesine)과 같은), 에피포도필로톡신(epipodophyllotoxins)(에토포사이드(etoposide) 또는 테니포사이드(teniposide)와 같은), 항생제(닥티노마이신(dactinomycin), 다우노루비신(daunorubicin), 독소루비신(doxorubicin), 블레노마이신(bleomycin), 필라카마이신(plicamycin), 또는 미토마이신 C(mitomycin C)와 같은), 및 효소 (L-아스파라기나제(L-asparaginase)와 같은)를 포함한다.
다양한 제제의 비제한적인 예들은 플래티늄배위결합복합체(platinum coordination complexes) (또한 시스플라틴(cisplatin)으로 알려진 시스-디아민-디클로프래티늄 II(cis-diamine-dichloroplatinum II)와 같은), 치환된 우레아 (하이드록시우레아(hydroxyurea)와 같은), 메틸 하이드라진(methyl hydrazine) 유도체(프로카바진(procarbazine)와 같은), 및 부신피질 억제제(adrenocrotical suppressants) (마이토테인(mitotane) 및 아미노글루테티미드(aminoglutethimide)와 같은)를 포함한다.
호르몬 및 길항제의 비제한적인 예들은 아드레노코르티코(adrenocorticosteroids)(프레드니손(prednisone)와 같은), 프로제스틴(progestins)(하이드록시프로제스테론 카프로에이트(hydroxyprogesterone caproate), 메드록시프로제스테론 아세트산염(medroxyprogesterone acetate), 및 메그에스트롤 아세트산염(magestrol acetate)과 같은), 에스트로젠(estrogens)(디에틸스틸베스트롤(diethylstilbestrol) 및 에티닐 에스트레디올(ethinyl estradiol)와 같은), 안티에스트로젠(antiestrogens)(타목시펜(tamoxifen)와 같은), 및 안드로젠(androgens)(테스테론 프로피오네이트(testerone proprionate) 및 플루옥시메스테론(fluoxymesterone)와 같은)을 포함한다.
가장 통상적으로 사용된 화학요법 약물의 예들은 아드리아마이신(Adriamycin), 알케란(Alkeran), 아라-C(Ara-C), BiCNU, 부설판(Busulfan), CCNU, 카르보플라티늄(Carboplatinum), 시스플라티늄(Cisplatinum), 사이톡산(Cytoxan), 다우노루비신(daunorubicin), DTIC, 5-FU, 플루다라빈(Fludarabine), 하이드리아(Hydrea), 아이다루비신(Idarubicin), 이포스파마이(Ifosfamide), 메토트렉사트(methotrexate), 미트라마이신(Mithramycin), 미토마이신(Mitomycin), 미톡산트론(Mitoxantrone), 질소 머스타드, 탁솔(또는 도세탁셀(docetaxel)과 같은 다른 탁산), 벨반(Velban), 빈크리스틴(Vincristine), VP-16을 포함하는 반면에, 일부 이상의 새로운 약물은 젬시타빈(Gemcitabine)(Gemzar), 허셉틴(Herceptin), 이리노테칸(Irinotecan) (켐토ㅅ르(Camptosar), CPT-11), 류스타틴(Leustatin), 나벨빈(Navelbine), 리툭산 STI-571(Rituxan STI-571), 탁소텔(Taxotere), 토포테칸(Topotecan)(하이캄틴(Hycamtin)), 젤로다(Xeloda)(Capecitabine), 제벨린(Zevelin) 및 칼시트리올(calcitriol)을 포함한다.
사용될 수 있는 면역조절제의 비제한적인 예들은 AS-101 (Wyeth-Ayerst Labs.), 브로피리민(bropirimine)(Upjohn), 감마 인터페론(gamma interferon)(Genentech), GM-CSF(과립구큰포식세포집락자극인자(granulocyte macrophage colony stimulating factor); Genetics Institute), IL-2(Cetus 또는 Hoffman-LaRoche), 인간 면역 글로불린(Cutter Biological), IMREG(New Orleans, La.의 Imreg로부터), SK&F 106528, 및 TNF(종양 괴사 인자; Genentech)을 포함한다.
암의 일부 유형을 위한 다른 통상적인 처치는 외과 치료, 예를 들면, 암 또는 이것의 일부의 외과적 절제이다. 다른 치료방법은 방사선 치료로서, 예를 들면 종양을 제거하거나 외과 절제하기 전에 이것을 줄어들게하는 것을 돕기 위해 종양 부위에 방사선 물질 또는 에너지(외부의 빔 치료와 같은)의 투여이다.
CDK(사이클린-의존성 키나아제) 저해제는 CDKs의 기능을 억제하는 제제이다. 상기 제공된 방법으로 사용을 위한 CDK 저해제의 비제한적인 예들은 AG-024322, AT7519, AZD5438, 플라보피리돌(flavopiridol), 인디술람(indisulam), P1446A-05, PD-0332991, 및 P276-00 (예를 들어, Lapenna et al., Nature Reviews, 8:547-566, 2009을 참조)을 포함한다. 다른 CDK 저해제는 LY2835219, 팔보시시브(Palbociclib), LEE011 (Novartis), 팬-CDK 저해제 AT7519, 셀리시스리브(seliciclib), CYC065, 부티로락톤 I(butyrolactone I), 히메니알디신(hymenialdisine), SU9516, CINK4, PD0183812 또는 파스카플리신(fascaplysin)을 포함한다.
일부 실시예에서, CDK 저해제는 광범위(broad range)의 저해제(플라보피리돌(flavopiridol), 올로모우신(olomoucine), 로스코비틴(roscovitine), 켄파울론(kenpaullone), SNS-032, AT7519, AG-024322, (S)-로스코비틴 또는 R547와 같은)이다. 다른 실시예에서, CDK 저해제는 특이적 저해제(파스카플리신, 류비딘(ryuvidine), 푸르발라놀 A(purvalanol A), NU2058, B㎖-259, SU 9516, PD0332991 또는 P-276-00와 같은)이다.
제제 및 복용량의 선택은 치료할 질병에 기초하여 당업자에 의해 쉽게 결정될 수 있다. 제제 또는 조성물의 조합은 부수적으로(예를 들어, 혼합물로서), 별도로 그러나 동시에(예를 들어, 별도의 정맥 내 주사라인을 경유하여)투여하거나 또는 순차적으로(예를 들어, 하나의 제제가 첫번째로 투여되고 뒤이어 두 번째 제제가 투여된다) 투여될 수 있다. 따라서, 조합의 용어는 2개 이상의 제제 또는 조성물의 부수적, 동시 또는 순차적 투여를 의미하는 것으로 사용된다.
본 명세서에서 개시된 방법에 따르면, 본 명세서에서 제공된 하나 이상의 제제의 유효량이 개체에게 투여된다. 상기 유효량은 원하는 생리학적 반응(예를 들어, 암세포의 살상)을 생성하는데 필요한 양으로 정의한다. 치료제는 일반적으로 매일 약 0.001 mg/kg 내지 약 1000 mg/kg의 초기 복용량으로 투여된다. 약 0.01 mg/kg 내지 약 500 mg/kg, 또는 약 0.1 mg/kg 내지 약 200 mg/kg, 또는 약 1 mg/kg 내지 약 100 mg/kg, 또는 약 10 mg/kg 내지 약 50 mg/kg의 용량 범위가 사용될 수 있다. 그러나, 복용량은 개체의 요구되는 정도, 치료되고자 하는 질환의 심각성, 및 사용되는 화합물에 의존하여 다양할 수 있다. 예를 들면, 복용량은 특정한 개체에서 진단된 암의 유형 및 단계를 고려하여 경험적으로 결정될 수 있다. 제공된 방법의 맥락에서, 개체에 투여되는 용량은 시간이 지남에 따라 환자에게 유익한 치료적 반응을 일으키기에 충분해야만 한다. 특정 상황을 위한 적절한 복용량의 결정은 종사자의 기술에 달렸다. 따라서, 제제를 투여하기 위한 유효량 및 계획은 당업자에 의해 경험적으로 결정될 수 있다. 복용량은 원하지 않는 교차-반응, 과민 반응 등과 같은 실질적 부작용을 야기할 정도로 많으면 안된다. 복용량은 임의의 금기(contraindications) 상황에서 주치의에 의해 조정될 수 있다. 약학적 제품의 종류에 대한 적절한 복용량에 대한 지침을 문헌에서 찾을 수 있다.
개시된 바와 같이, 종양세포를 재조합 아데노바이러스, 또는 이의 조성물과 접촉시켜 종양세포 생존능을 저해하는 방법을 여기에서 제공된다. 일부 실시예에서, 방법은 시험관 내 방법이다. 다른 실시예에서, 그 방법은 생체 내 방법이고 종양세포를 접촉시키는 것은 종양이 있는 개체에게 재조합 아데노바이러스 또는 조성물을 투여하는 것을 포함한다.
본 명세서에서 개시된 재조합 아데노바이러스(또는 이의 조성물)의 치료학적 유효량을 개체에게 투여하여, 개체의 종양 진행을 저해시키거나 종양 부피를 감소시키는 방법이 또한 제공된다.
또한 본 명세서에서 개시된 재조합 아데노바이러스(또는 이의 조성물)의 치료학적 유효량을 개체에게 투여하여, 개체의 암을 치료하는 방법이 제공된다.
추가적으로 (i) 라파마이신/라파로그(rapamycin/rapalog) 유도성의 재표적화된(retargeted) 재조합 아데노바이러스의 치료학적 유효량; 및 (ⅱ) 라파마이신 또는 이의 유사체를 개체에게 투여하여 개체의 종양 부피를 감소시키는 방법을 제공한다. 또한 (i) 라파마이신/라파로그(rapamycin/rapalog) 유도성의 재표적화된 재조합 아데노바이러스의 치료학적 유효량; 및 (ⅱ) 라파마이신 또는 이의 유사체를 개체에게 투여하여 개체의 암을 치료하는 방법이 제공된다.
일부 실시예에서, 라파마이신 또는 라파마이신 유사체는 약 0.1 mg/kg 내지 약 2.0 mg/kg의 용량으로 투여된다. 다른 실시예에서, 라파마이신은 약 0.1 mg/kg 내지 약 0.5 mg/kg의 용량으로 투여된다. 일부 실시예에서, 라파마이신은 약 0.1 mg/kg, 0.5 mg/kg, 1.0 mg/kg, 1.5 mg/kg 또는 2.0 mg/kg의 용량으로 투여된다.
일부 실시예에서, 라파마이신 또는 라파마이신 유사체는 약 3 내지 12 mg/m2, 또는 약 5 내지 10 mg/m2와 같은, 약 1 내지 15 mg/m2의 용량으로 투여된다. 일부 실시예에서, 라파마이신 또는 라파마이신 유사체는 약 1, 약 2, 약 3, 약 4, 약 5, 약 6, 약 7, 약 8, 약 9, 약 10, 약 11, 약 12, 약 13, 약 14 또는 약 15 mg/m2의 용량으로 투여된다.
일부 실시예에서, 라파마이신 또는 라파마이신 유사체는 개체에 실질적 면역억제의 원인을 일으키지 않는 용량으로 투여된다. '실질적 면역억제의 원인을 일으키지 않는 용량'의 라파마이신 또는 이의 유사체의 투여는 특정한 개체에 대하여 유효한 농도 25 (EC25)보다 적거나 동등한 용량을 의미한다. 당업자는 개체에서 실질적 면역억제를 일으키지 않는 라파마이신 또는 이의 유사체의 용량을 결정할 수 있다(예를 들어, Schubert et al., Am J Transplant 4:767-773, 2004를 참조). 일부 실시예에서, EC25는 약 3 ng/㎖ 내지 약 10 ng/㎖와 같은, 약 1 ng/㎖ 내지 약 15 ng/㎖이다. 비제한적인 실시예에서, EC25는 약 1 ng/㎖, 약 2 ng/㎖, 약 3 ng/㎖, 약 4 ng/㎖, 약 5 ng/㎖, 약 6 ng/㎖, 약 7 ng/㎖, 약 8 ng/㎖, 약 9 ng/㎖, 약 10 ng/㎖, 약 11 ng/㎖, 약 12 ng/㎖, 약 13 ng/㎖, 약 14 ng/㎖ 또는 약 15 ng/㎖이다.
일부 실시예에서, 재표적화된(retargeted) 아데노바이러스의 게놈은 FKBP에 융합된 표적 리간드, 및 야생형 FKBP-라파마이신 결합(FRB) 단백질 또는 T2098L 치환을 포함하는 돌연변이 FRB 단백질에 융합된 아데노바이러스 섬유 단백질을 암호화한다. 일부 실시예에서, 표적 리간드는 EGFR 특이적인 단일 도메인 항체와 같은, 단일 도메인 항체이다. 특정 비제한적인 예에서, 재조합 아데노바이러스의 게놈은 AdSyn-CO335(서열번호 30), AdSyn-CO335B-K(서열번호 92) 또는 AdSyn-CO335B-TK(서열번호 97)의 뉴클레오티드 서열을 포함한다.
방법의 일부 실시예에서, 종양 또는 암은 E2F 경로의 비정상적인 조절(deregulation)이 특징이다. 방법의 일부 실시예에서, 종양 또는 암은 폐, 전립선, 직장, 유방, 갑상선, 신장 또는 간의 종양 또는 암이거나, 또는 백혈병이다
일부 실시예에서, 방법은 화학치료제, 면역 조절제 또는 CDK 저해제, 예를 들면 CDK4 저해제와 같은 추가적인 치료제로 개체를 치료하는 것을 더 포함한다.
하기의 예는 특정한 특성 및/또는 실시예를 설명하는 것을 제공한다. 하기 실시예가 설명된 특정한 특성 또는 실시예에 대한 개시를 제한하는 것으로 해석되어서는 안된다.
실시예
실시예 1: 비정상적인 E2F 활성을 가진 종양 세포에서 선별적으로 복제하는 종양 살상 아데노바이러스
변형된 아데노바이러스는 본 명세서에서 참고로 인용된, PCT 공개번호 WO 2012/024351에서 설명된 방법에 따라, 하기의 참조된 구성요소로 만들었다. 게이트웨이 pDONR 벡터를 사용하였다. 인간 Ad5 DNA로부터, E1 모듈을 PCR로 얻고 SLIC를 사용하여 벡터 pDONR P1P4로 삽입하였다. attL1 및 attL4 재조합 부위를 포함하는 pDONR P1P4 벡터 백본(backbone)을 PCR을 이용하여 증폭하였고 SLIC로 Ad5 E1 모듈과 결합시켰다. E3 모듈을 PCR하여 attB5 및 attB3r 재조합 부위가 양 측면에 위치한(flanked) 생성물을 생성하였다. 생성물을 게이트웨이 BP 반응에 의해 pDONR P5P3r 벡터로 삽입하였다. E4 모듈을 PCR하여 attB3 및 attB2 재조합 부위가 양측면에 위치한 생성물을 얻었다. 생성물을 게이트웨이 BP 반응으로 pDONR P3P2 벡터로 삽입하였다. pDONR P5P2 벡터로부터 attR5-ccdB-Cm(r)-attR2 단편을 PCR로 증폭시키고 에드셈블리 데스트 벡터(Adsembly DEST vector)로 삽입하였다(“MultiSite Gateway®ProPlus”, Cat# 12537-100; 및 Sone et al., J Biotechnol 136(3-4):113-121, 2008를 참조). 에드셈블리(Adsembly) 방법은 전부 본 명세서에 참조문헌으로 삽입된, PCT 공개번호 WO 2012/024351에 기술되어 있다.
에드셈블리 데스트 벡터(Adsembly DEST vector)를 위한 벡터 백본은 3개의 다른 출처 유래의 부분들로 구성된다. Amp(r) 카세트 및 lacZ 유전자를 플라스미드 pUC19으로부터 증폭하였다. 이것을 BioBricksiGEM 2007 부품(parts) 배포의 일부이며, 플라스미드 pSB3K5-I52002로부터 얻은, p15A 복제원점(p15A origin 의 replication)과 결합시켰다. 낮은 복제 수(10-12)의 플라스미드를 유지하는 p15A ori는 E1 독성을 감소시키는데 필요하다. 마지막으로, 자가-절단 바이러스(self-excising virus)를 만들기 위해서, 효소 ISceI에 대한 포유동물 발현 카세트를 플라스미드 pAdZ5-CV5-E3+로부터 PCR 증폭시켰다. 상기 카세트를 벡터 백본으로 클론닝하여 p15A-SceI라고 불리는 벡터로 제조하였다. 이것은 게놈 조합(assembly)을 시작하기 위해 사용될 벡터이다. 유전자 모듈을 야생형 Ad5 바이러스로부터 정제된 DNA 또는 플라스미드 pAd/CMV/V5/DEST(인비트로젠)로부터 얻었다.
인간 Ad5에 대한 DEST 벡터에 관해서, E2 및 L3 모듈을 3-단편 SLIC에 의해 플라스미드 p15A-SceI로 삽입하였다. attR5 및 attR2 부위가 양측면에 위치한 ccdB 및 Chlor(r)를 발현하는 역선택 마커를 플라스미드 pDONR P5P2로부터 PCR하여 얻었다. 두번째 역선택 마커를 벡터 pDONR P1P4로부터 PCR하여 얻었다. 2개의 역선택 마커를 E2 및 L4 모듈 끝에 조작된 고유의 제한효소로 자른 후에 SLIC로 p15A-SceI E2-L4의 오른쪽 및 왼쪽에 삽입하여 DEST 벡터를 만들었다.
Amp(r) 카세트: 플라스미드 pUC19에 관하여, p15A ori: 플라스미드 pSB3K5-I52002는 BioBricksiGEM 2007 부품(parts) 배포의 일부이다. 아데노바이러스 유전자 모듈에 관하여, DNA를 Ad5 입자 또는 플라스미드 pAd/CMV/V5/DEST(인비트로젠)으로부터 정제하였다. DONR 벡터 pDONR P1P4, P5P2, P5P3R, P3P2를 인비트로젠으로부터 입수하였다.
모든 PCR 분석은 퓨전(Phusion) 효소(NEB)를 사용하여 수행하였다. Ad5로부터 아데노바이러스 유전자(ADENOVIRAL GENE) 모듈을 얻기 위한 PCR 분석은 1x HF 버퍼, 200 μM의 각각의 dNTP, 0.5 μM의 각각의 프라이머, 및 10 ng의 템플레이트로 수행되었다. E2-L2 모듈을 위하여, 3% DMSO를 첨가하였다. 템플레이트는 플라스미드 pAd/PL-DEST(인비트로젠; E2-L2, L3-L4, 및 E4 모듈을 위한)이거나 또는 Ad5 게놈 DNA(E1 및 E3 모듈을 위한)이었다. PCR 조건은 하기와 같다:
E2-L2 및 L3-L4: 98℃ 30초 - 98℃ 10초, 65℃ 30초 (매 2 사이클마다 온도 1℃ 감소), 72℃ 7분의 10 사이클 - 98℃ 10초, 60℃ 30초, 72℃ 8분의 29 사이클 - 72℃ 10분 - 4℃ 유지.
E3: 98℃ 30초 - 98℃ 10초, 70℃ 30초 (매 사이클마다 온도 0.5℃ 감소), 72℃ 2분30초의 10 사이클 - 98℃ 10초, 68℃ 30초, 72℃ 2분30초의 25 사이클 - 72℃ 10분 - 4℃ 유지.
E4: 98℃ 30초 - 98℃ 10초, 63℃ 30초 (매 사이클마다 온도 0.5℃ 감소), 72℃ 2분의 6 사이클 - 98℃ 10초, 60℃ 30초, 72℃ 2분의 29 사이클 - 72℃ 5분 - 4℃ 유지.
정제된 바이러스로부터 바이러스 게놈 DNA를 얻기 위하여, 정제된 바이러스의 100 ㎕를 10 mM 트리스 pH8, 5 mM EDTA, 200 mM NaCl, 및 0.2% SDS를 포함하는 300 ㎕의 용해 버퍼에 첨가했다. 혼합물을 60℃에서 5분 동안 배양하고, 이어서 5 ㎕의 프로테이나제 K(~20 mg/㎖)를 추가하고 1 시간 동안 60℃에서 추가로 배양하였다. 그런 다음 시료를 5분 동안 얼음에 방치하고, 이어서 15분 동안 15K x g에서 회전(spinning)시켰다. 상층액을 제거하고 동일 부피의 이소프로판올을 첨가하고, 잘 혼합하여 4℃에서 15분 동안 15K x g에서 회전하였다. 펠렛을 70% 에탄올로 세척하였고 4℃에서 15분 동안 재회전시켰다. 펠렛을 건조시키고 재현탁하여 사용하였다.
SLIC에 관하여, 선형 단편(linear fragment)을 하기의 20 ㎕ 반응에서 상온에서 20분 동안 엑소뉴클리즈(exonuclease)로 처리되었다: 50 mM 트리스 pH8, 10 mM MgCl2, 50㎍/㎖ BSA, 200 mM 우레아, 5 mM DTT, 및 0.5 ㎕ T4 DNA 폴리머라제. 반응을 1 ㎕ 0.5M EDTA를 첨가하여 중지시키고, 이어서 20분 동안 75℃에서 배양하였다. 동일한 양의 T4-처리된 DNA를 새로운 튜브의 대략 20 ㎕ 부피로 혼합하였다. 2개의 단편을 혼합한 SLIC에 대하여, 각각의 반응액의 10 ㎕를 사용하였다. 3개의 단편을 혼합한 SLIC에 대하여, 각각의 반응액의 7 ㎕를 사용하였다. 단편을 10분 동안 65℃로 가열하여 어닐링(annealed)하였고, 이어서 매 5 초마다 온도를 0.5℃ 천천히 감소시켜 25℃로 낮추었다. 어닐링한 후, 반응액의 5 ㎕를 형질전환시키고 클론을 스크리닝하였다.
AdSlicR에 관하여, 3-단편 SLIC 반응을 100 ng의 T4-처리된 p15A-SceI (PCR에 의해 직선화됨), 및 각각의 E2 및 L3 모듈의 300 ng을 사용하여 수행하였다(이들의 각각의 엔트리 벡터로부터 PCR에 의해 수득하였다). 벡터 p15A-SceI E2-L4이 만들어졌다. 5㎍의 p15A-SceI E2-L4를 SwaI로 자르고 Qiagen QiaexII을 사용하여 젤 정제화하였다. E3 및 E4 모듈을 이들의 각각의 엔트리 벡터로부터 PCR에 의해 수득하였다. 각각의 직선화된 벡터(450 ng) 및 PCR 생성물(200 ng)을 T4 DNA 폴리머라제로 처리하고 SLIC를 150-200 ng의 벡터 및 ~100 ng의 각각의 모듈 PCR을 사용하여, 통상적인 방법으로 수행하였다. 양성 클론을 분리한 후, 5㎍의 새로운 벡터를 PacI로 자르고 젤 정제한 다음, 새로운 SLIC 반응에서 E1 PCR 생성물(100 ng의 T4-처리된)과 결합시켰다. 게놈 조합이 완성되었고, 바이러스를 재구성하기 위한 형질감염을 위한 플라스미드가 준비되었다.
E1 및 E4 돌연변이의 영역을 제조하기 위하여, 각각의 모듈 엔트리 벡터 상에서 조작을 수행하였다. 벡터 백본이 있는 E1 모듈을 LTCHE 서열(서열번호 32의 122-126잔기)이 결여된 생성물을 생성하기 위한 프라이머로 PCR 증폭한 후, SLIC을 사용하여 원형으로 하여(circularized) pENTR-E1-E1A-ΔLXCXE을 생성하였다.
또한, pENTR-E1-E1A-Y47H, pENTR-E1-E1A-C124G, 또는 pENTR-E1-E1A-Δ2-11을 각각 생성하기 위하여 벡터 백본을 가진 E1 모듈을 Y47을 H로, C124를 G로 변이시키거나 또는 잔기 2-11을 제거하기 위한 E1A 코돈 변이들(ENTR-E1-E1A-Y47H-C124G 및 pENTR-E1- E1A-Y47H-C124G-Δ2-11)을 가진 생성물을 생성하기 위하여 프라이머로 PCR 증폭하였다. 상기 생성물을 상기 돌연변이 조합을 생성하기 위한 추가 PCR 돌연변이를 위하여 템플레이트로 사용하였다. 벡터 백본을 가진 E4 모듈을 E4orf6 종결코돈의 하류(downstream)에 E4orf6/7-특이적 엑손 서열(297 bp)이 결함된 생성물을 생성하기 위한 프라이머로 PCR 증폭하여 pENTR-E4-ΔE4orf6/7을 생성하였다. 상기 생성물은 E4orf1의 PDZ-결합 모티프, 또는 전체 E4orf1 서열이 결여된(각각 pENTR-E4-ΔE4orf6/7-E4orf1ΔPDZb 및 pENTR-E4-ΔE4orf6/7-ΔE4orf1) 생성물을 생성하기 위한 프라이머로 PCR을 하기 위한 템플레이트로서 또한 사용될 수 있다.
돌연변이를 가진 완전한 바이러스 게놈을 생성하기 위하여, 야생형 E3 모듈 및 야생형 E4 또는 돌연변이의 E4 모듈, 그런 다음 야생형 E1 또는 돌연변이의 E1과 조합한 p15A-SceI E2-L4를 사용하여 AdSlicR이 수행되었다. 야생형 AdSlicR 아데노바이러스를 하기의 표 1에서 표기하였다.
표 1. E1 및 E4에서 변형을 가진 아데노바이러스
바이러스 명칭 E1 E4 서열번호
AdSyn-CO102 wt wt 1
AdSyn-CO210 wt ΔE4orf6/7 2
AdSyn-CO283 wt E4orf1 ΔPDZb, ΔE4orf6/7 3
AdSyn-CO284 wt ΔE4orf1, ΔE4orf6/7 4
AdSyn-CO189 E1A ΔLXCXE wt 5
AdSyn-CO181 E1A ΔLXCXE ΔE4orf6/7 6
AdSyn-CO285 E1A ΔLXCXE E4orf1 ΔPDZb, ΔE4orf6/7 7
AdSyn-CO286 E1A ΔLXCXE ΔE4orf1, ΔE4orf6/7 8
AdSyn-CO235 E1A C124G wt 9
AdSyn-CO287 E1A C124G ΔE4orf6/7 10
AdSyn-CO288 E1A C124G E4orf1 ΔPDZb, ΔE4orf6/7 11
AdSyn-CO289 E1A C124G ΔE4orf1, ΔE4orf6/7 12
AdSyn-CO236 E1A d2-11 wt 13
AdSyn-CO290 E1A d2-11 ΔE4orf6/7 14
AdSyn-CO291 E1A d2-11 E4orf1 ΔPDZb, ΔE4orf6/7 15
AdSyn-CO292 E1A d2-11 ΔE4orf1, ΔE4orf6/7 16
AdSyn-CO238 E1A Y47H, C124G wt 17
AdSyn-CO293 E1A Y47H, C124G ΔE4orf6/7 18
AdSyn-CO294 E1A Y47H, C124G E4orf1 ΔPDZb, ΔE4orf6/7 19
AdSyn-CO295 E1A Y47H, C124G ΔE4orf1, ΔE4orf6/7 20
AdSyn-CO244 E1A Y47H, C124G, d2-11 wt 21
AdSyn-CO296 E1A Y47H, C124G, d2-11 ΔE4orf6/7 22
AdSyn-CO297 E1A Y47H, C124G, d2-11 E4orf1 ΔPDZb, ΔE4orf6/7 23
AdSyn-CO298 E1A Y47H, C124G, d2-11 ΔE4orf1, ΔE4orf6/7 24
바이러스 생성물, 농도 및 정제에 관하여, 293 E4 세포를 감염 입자로 감염시키고, CPE가 분명해지는 감염 후 약 48시간 째에, 세포를 수득하고 5분 동안 500 x g 에서 원심분리를 통해 분리하였다. 세포를 TMN 버퍼(10 mM TrisCl pH 7.5, 1 mM MgCl2, 150 mM NaCl)상에서 냉동/해동을 3번 반복하여 용해하였고, 세포 잔해는 15분 동안 3,000 x g 및 3,500 x g 에서 2회 원심분리하여 제거되었다. 세슘 클로아이드 구배(cesium chloride gradient)(0.5 g/㎖)는 18 내지 24시간 동안 37,000 x g에서 초고속원심분리를 통한 바이러스 입자의 밴드(band)화에 이용되었다. 밴드를 수득하고 4℃에서 하룻밤(12-18시간) 동안 10% 글리세롤을 포함한 TMN에 있는 10,000 MWCO Slide-A-Lyzer® 투석 카세트(Thermo Scientific) 상에서 투석하였고, -80℃에서 저장하였다. 정제된 바이러스의 역가(titer)는 항-아데노바이러스 유형 5개의 주요 항체(ab6982, Abcam), 및 ImmunoPure 항-래빗 알칼린 포스파타제 2차 항체(Thermo Scientific)를 이용, 세포-기반 순차적 희석(cell-based serial dilution) 감염 ELISA로 역가가 결정된 야생형 균주와 비교하여 결정되었다.
1차 인간 소기도 상피세포(SAEC)의 감염 동안에 아데노바이러스 단백질 발현을 평가하기 위하여, 2-웰 플레이트에서 휴지기상태의 SAEC를 MOI 30 아데노바이러스로 감염시키고, 감염후 4 시간째에 배지를 교체하였다. 감염 후 24, 36, 및 48시간째에, 세포를 차가운 PBS로 세척하였고, 500 ㎕의 차가운 PBS에서 수득, 4℃에서 5분 동안 5,000 rpm에서 펠렛화하고, 재빨리 냉각하여 -80℃에서 저장하였다. 세포 펠렛을 컵 초음파파쇄기(cup sonicator) (4℃에서 60 엠플리튜드 2x 60 초 펄스)로 초음파처리(sonocation)를 포함하여, RIPA 버퍼(100 mM 트리스 pH7.4, 300 mM NaCl, 2mM EDTA, 2% 트리톤 X, 2% 데옥시콜레이트, 2 mM NaF, 0.2 mM NaVO4, 2 mM DTT)에서 4℃에서 1 시간 동안 용해시켰다. 세포 잔해를 4℃에서 20분 동안 13,000 rpm에서 원심분리하여 펠렛화시켰다. 단백질 농도는 Bio-Rad의 DC™ 단백질 분석을 사용하여 결정되었고, 시료의 단백질 농도는 정규화(normalization)되었다. Life Technologies Novex® NuPAGE® SDS-PAGE 젤을 사용하여, 제조사의 프로토콜에 따라, 젤 전기영동을 수행하였다. 단백질을 웨스턴 블랏으로 검출하였다. 단백질 검출에 사용된 1차 항체는 다음과 같다: E1A(ab28305, Abcam), β-엑틴(A5441, Sigma), Ad5 후기(late) 단백질(ab6982, Abcam), 사이클린 A(Ab-6 6E6, NeoMarkers), 사이클린 B(Ab-3 GNS1, NeoMarkers). 알렉사 플루오로® 항체(Life Technologies)를 2차 항체로서 사용하였고, 신호를 LI-COR ODYSSEY® 기계를 사용하여 검출하였다. 폐 선암 A549 세포 및 정상적인 인간 성상세포 (NHA)를 감염시키는 동안에 아데노바이러스 단백질 발현을 측정하기 위하여, 12-웰 플레이트 상의 가득찬 세포를 MOI 10의 아데노바이러스로 감염시키고, SAEC에 대해서 설명된 바와 같이 유사하게 처리하였다. 교모세포종 U87 세포, 교모세포종 U118 세포, 인간 혈관 내피세포(HuVEC), 또는 인간 섬유아세포의 감염 동안에 아데노바이러스 단백질 발현을 측정하기 위하여, 12-웰 플레이트 상의 가득찬 세포를 MOI 20의 아데노바이러스로 감염시키고, SAEC에 대해서 설명된 바와 같이 유사하게 처리하였다.
세포주기 분석을 수행하기 위하여, 단백질 발현에 수행한 바와 같이 세포를 동일한 MOI로 감염시켰다. 감염 후 48시간째에, 세포를 플레이트에서 트립신화하고 차가운 PBS로 세척하였다. 세포를 500 ㎕ 차가운 PBS에 재현탁하고, 3 ㎖의 차가운 70% EtOH/15 mM 글라이신, pH 2.8 용액에서 고정하였다. 시료를 4℃에 보존하고, FACS 분석에 앞서 세포를 펠렛화하고, 차가운 PBS로 세척하고, 프로피디움 요오드화물 (PI)/RNase A 용액에서 재현탁한 후, 1시간 동안 37℃에서 배양하였다. 각각 시료에 대하여 FACS에 의해 적어도 10,000 이벤트(event)를 수득하였다.
감염으로부터 아데노바이러스 버스트(burst)를 평가하기 위하여, 12-웰 플레이트의 휴지기상태의 세포를 감염다중도 1 또는 감염다중도 10의 아데노바이러스로 감염시키고, 감염 후 4시간째에 배지를 세포상에서 교체하였다. 웰로부터의 배지를 감염 후 48 및 72시간째에 수득하였고, 재빨리 냉동시키고 1회 해동시킨 후, 세포 잔해를 펠렛화시키기 위해 5분 동안 4℃에서 7,000 rpm에서 원심분리하였다. 배지의 부피를 측정하고 재빨리 냉동시켜 -80℃에서 저장하였다. 배지의 역가(titer)는 항-아데노바이러스 타입 5 1차 항체 (ab6982, Abcam) 및 ImmunoPure 항-래빗 알칼린 포스파타제 2차 항체(Thermo Scientific)를 이용, 세포-기반 순차적 희석 감염 ELISA로 역가가 결정된 야생형 균주와 비교하여 결정되었다.
세포 생존능 분석에 관하여, 세포를 96-웰 플레이트에 분주하였고, MOI 30에서 연속 희석으로 트리플리게이트(triplicate) 감염시켰다. 감염 후 7-10 째에 MOI 10으로 감염된 웰에서 완전한 CPE가 형성되었을 때, 대사 활성을 세포 증식제제 WST-1 (Roche)를 사용하여 제조사의 프로토콜에 따라 측정하였다.
상기에서 논의한 바와 같이, 암은 추가적 치료제를 필요로 하는 골칫거리 질병이다. 치료제의 하나는 종양 살상 바이러스를 포함한다. 아데노바이러스는 종양 살상 바이러스로서 사용을 위해 연구되고 있는 바이러스의 하나이다. 망막아세포종(Rb) 종양 억제인자 경로(Rb tumor suppressor pathway) 기능은 Rb의 직접적 돌연변이에 의해, CDK-저해제인 p16 기능(예를 들어 돌연변이/메틸레이션에 의해)에 의해, 또는 CDK/사이클린의 증폭에 의해 거의 모든 인간 암에서 소실되었다. 정상적 비-분열 세포에서, Rb는 저인산화 상태(hypophosphorylated)를 유지되고, 자체의 표적 프로모터에서 전사인자 E2F에 결합, 크로마틴-재형성 복합체(chromatin-remodeling complexes) 및 히스톤-변형 활성 도메인(histone-modifying activities domain)을 리쿠르트(recruit)할뿐만 아니라 E2F 전사촉진 도메인을 차폐(masking)하여 전사를 억제한다. 세포주기의 G1-S 전이 동안에, CDKs는 E2F 억제를 완화하는 Rb를 인산화시킨다. 아데노바이러스는 세포를 바이러스 게놈을 복제하고 재생산하도록 만들기 위해 Rb 종양 억제인자 경로를 불활성화시키는 초기 바이러스 종양 단백질(viral oncoprotein)을 발현한다. 아데노바이러스 E1A는 부분적으로, LXCXE 모티프를 경유하여, Rb의 종양 억제인자 활성을 비정상적으로 조절하면서 Rb에 결합한다. 따라서 E1A에 LXCXE 모티프를 삭제하는 것은 Rb의 불활성화를 제거할 것이고, 선별적으로 복제하는 바이러스 (ONYX-838)를 만들 것으로 생각된다. 그러나, Johnson et al. (Cancer Cell, 1(4):325-337, 2002)은 본 명세서에 기술된 실험결과와 상응하게, Ad E1A LXCXE 돌연변이가 S-단계 진입, 바이러스 DNA 복제, 및 후기(late) 단백질 발현을 방지하는데 충분하지 않다는 증거를 제공한다. E1A 돌연변이의 Rb-선택성(selectivity)은 논쟁이 있음에도 불구하고, 상기 돌연변이는 임상 시험 2상(phase II clinical trials)으로 들어가고 있는 악성 뇌종양에 대한 종양 살상 바이러스(DNX-2401)의 기초로서 추진되고 있다. 높은 Rb-선택성(selectivity)을 얻기 위한 시도에서, 아데노바이러스의 E1 및 E4 영역(region)에 대한 프로모터를 E2F의 프로모터로 치환하고, ONYX-411을 생성하기 위하여 E1A ΔLXCXE 모티프와 조합된 아데노바이러스를 생성하였다(Johnson et al., Cancer Cell, 1(4):325-337, 2002; 및 Dubensky et al., Cancer Cell, 1(4):307-309, 2002). 상기 바이러스를 테스트하기 위하여, 종양 및 초대 인간 세포를 야생형 바이러스, ONYX-838 (E1A ΔLXCXE) 또는 ONYX-411로 감염시켰고 감염 후에 다양한 시점에서 수득하였다. ONYX-838은 종양 및 주요 폐 상피 세포에서 분별없이 복제한다. 아데노바이러스 E1A, E1B 및 E4 영역의 세포내 E2F에 의한 조절과 조합된 E1A ΔLXCXE를 가진 ONYX-411는 정상 세포와 대비하여 종양 세포에서 선별적-복제를 나타냈다(Johnson et al., Cancer Cell 1(4):325-337, 2002). 그러나, 종양세포에서 E2F 프로모터는 재조합이 일어나 야생형 바이러스 수준으로 복제가 제한되었다.
본 명세서에서 설명된 바와 같이, E1A의 Rb 억제를 통한 E2F의 방출(release)과는 독립적으로, 세포 내 프로모터 및 Ad 프로모터에서 E2F 단백질 을 추가로 안정화시키는 다른 Ad 단백질, E4orf6/7이 있다. E1A 및 E4orf6/7은 함께 E2F에 의한 전사를 유도, S-단계 개시 및 그에 따른 바이러스 DNA 게놈의 증식을 일으킨다. 따라서, 기능적 Rb가 결여된 종양 세포에 선택적인 종양 살상 바이러스 치료제인 E1A 변형, E4orf1 변형 및/또는 E4orf6/7 변형을 가지는 재조합 아데노바이러스가 여기에 제공된다. 특정적으로, E1A/E4orf1/E4orf6/7에서 화합물 돌연변이는 초대 세포가 아닌 종양 세포에서 선별적으로 복제될지를 결정하도록 조작되었다. 상기 돌연변이의 조합은 암에 있어서 효과적이고, 자기-증폭적 치료제가 될 수 있음이 제안된다.
정상(non-tumor) 세포 및 종양 세포에서 상기 바이러스를 테스트하기 위하여, 세포를 목(mock) 감염하거나 또는 AdSyn-CO102(야생형), AdSyn-CO181(E1A ΔLXCXE/ΔE4orf6/7), AdSyn-CO189 (E1A ΔLXCXE), 또는 ONYX-838 (E1A ΔCR2)으로 감염시켰다. 또한 ONYX-838은 E1A의 CR2 도메인에 있는 ΔLXCXE가 없다. 휴지기상태의 인간 초대 소기도 상피세포(SAEC)(비종양 세포)는 감염다중도 10으로 감염되었다. AdSyn-CO102는 감염의 후기 시기(later times)에 E1A 수준의 예산된 바와 같이 감소를 나타냈다(도 1A). 유사하게, AdSyn-CO189 또는 ONYX-838로 감염된 세포에서, 감염의 후기 시기에 E1A 발현 수준의 감소가 있다; 그러나, 보다 초기에는, E1A의 발현이 AdSyn-CO102가 감염된 세포에서의 E1A의 발현보다 높았다. 반대로, AdSyn-CO181은 감염 전반에 걸쳐 강하고 지속된 E1A 발현을 나타냈으며, 이것은 아데노바이러스 생활사(lifecycle)를 톨한 진행이 실패했음을 나타낸다. 가득찬(confluent) 폐 선암(A549) 세포(종양세포)는 MOI 30에서 감염시켰다. 모든 감염은 감염 동안의 후기 시기에 E1A 수준의 예측된 감소를 초래하였으며(도 1B), 이는 전형적인 아데노바이러스 생활사 진행을 의미한다.
SAEC 또는 A549 세포를 돌연변이 아데노바이러스로 감염시킨 후에 후기(Late) 아데노바이러스 단백질 및 세포내 사이클린 단백질 발현을 도 2A(SAEC) 및 도 2B(A549 세포)에 나타냈다. 야생형 바이러스 및 E1A 돌연변이 단독을 가진 바이러스와 대조적으로, AdSyn-CO181은 SAEC에 있는 E2F-의존적 세포주기 표적, S 단계, 사이클린 A 및 사이클린 B를 활성화하지 못하였다. 추가적으로, E4orf6/7 돌연변이를 가진 AdSyn-CO181 및 AdSyn-CO201은 SAEC에 있는 후기(Late) 단백질 발현 및 복제가 결함이 있다. 상기 결함 모두는 AdSyn-CO210에 더 적은 것이 명백하다. 감염된 초대 세포와 대조적으로, A549 세포에서 후기 구조 단백질의 발현에 결함이 없었고, 사이클린 A 및 사이클린 B는 감염된 A549 시료 모두에 존재한다.
감염된 SAEC 및 A549 세포의 DNA 복제는 도 3A 및 3B에 나타냈다. AdSyn-CO181 감염은 AdSyn-CO102에 상대적으로 SAEC에서 강한 DNA 복제결함을 나타냈고, 이것은 감소된 바이러스 복제와 연관되어 있다. 사소한(modest) 결함은 이 시점의 AdSyn-CO210 감염된 SAEC에서 또한 뚜렷하다. A549 세포에서 나타나지 않았다.
도 4A-4B는 감염된 SAEC 및 A549 세포로부터 아데노바이러스 버스트(burst)을 나타낸다. AdSyn-CO181 및 AdSyn-CO210 감염 모두는 AdSyn-CO102와 네 비해 SAEC에서 강한 복제 결함을 나타냈다(도 4A). AdSyn-CO210을 제외한, A549 세포에서 바이러스 복제의 결함이 없었다(도 4B).
도 5A-5B는 감염 7일 후에 SAEC 및 A549의 세포 생존능을 나타낸다. AdSyn-CO102와 비교하여, AdSyn-CO181은 SAEC에서 감소된 세포 살상능을 나타낸다. 도 5B에 나타낸 바와 같이, 테스트된 돌연변이 바이러스는 A549 세포에서 야생형 바이러스와 비교하여 세포 살상에 결함이 없었다.
또한, 재조합 바이러스는 정상적인 인간 성상세포(NHA)(도 6A-6C), 교모세포종 U87 세포(도 7A-7C), 교모세포종 U87 세포(도 8A-8C) 및 IMR90 세포 (도 9A-9C)에서 테스트되었다. NHA에서, AdSyn-CO181은 사이클린 A를 유도하지 않고, AdSyn-CO102와 비교하여 지연되고 감소된 후기 바이러스 단백질 발현을 나타냈으며, 이것은 복제 결함을 표시한다(도 6A). 추가적으로, 감염 입자의 수 (도 6B) 및 DNA 함량(도 6C)에 의해 측정된 것처럼, AdSyn-CO181은 야생형 AdSyn-CO102와 비교하여, NHA에서 약화된 감염을 나타냈다. NHA 세포와는 대조적으로, 돌연변이 아데노바이러스는 교모세포종 U87 세포(도 7A-7C) 또는 교모세포종 U118 세포(도 8A-8C)에서 복제결함을 나타내지 않았다. AdSyn-CO181은 IMR90 세포에서 사소한 복제 결함을 나타냈다(도 9A-9C).
따라서, 상기에서 설명된 데이타는 야생형 및 E1AΔCR2 바이러스와는 대조적으로, E1AΔCR2/ΔE4orf6/7 및 ΔE4orf6/7 바이러스는, 캡시드(capsid) 단백질 발현 부족, E2F 표적 유전자(cyclin A 및 B)의 발현 유도 실패, S 단계 진입 및 바이러스 복제의 실패로 증명된 것처럼, 초대 세포에서 복제를 거의 하지 못한다. 반대로, 상기 바이러스는 A549 세포 및 일련의 종양 세포주들에서 야생형 바이러스 수준 만큼 복제한다. 따라서, 본 명세서에서 개시된 재조합 아데노바이러스는 선별적 암 치료제이다.
E4orf1에서 돌연변이를 포함하여(표 1 참조), 돌연변이 아데노바이러스들의 복제 특성의 결과를 도 10-15에 나타냈고, 도 16에 요약하였다. 도 10은 감염 10일 후에 초대 정상 인간 성상세포(NHA)의 세포 생존능을 나타내는 그래프이다. 도 11은 감염 9 일후에 휴지기상태의 정상 소기도 상피세포 (SAEC-hTERT)의 세포 생존능을 나타내는 그래프이다. 도 12는 감염 10 일후에 증식하는 SAEC-hTERT 세포의 세포 생존능을 나타내는 그래프이다. 도 13은 감염 7 일후의 인간 폐 선암 세포(A549)의 세포 생존능을 나타내는 그래프이다. 도 14는 감염 7 일후의 인간 유방암 세포(MDA MB 231)의 세포 생존능을 나타내는 그래프이다. 도 15는 감염 7 일후의 감염된 교모세포종 세포 (U87)의 세포 생존능을 나타내는 그래프이다. 도 16은 감염 7 일후의 초대 NHA, SAEC-hTERT(휴지기상태의), SAEC-hTERT(증식), A549, MDA MB 231, 및 U87 세포의 세포 생존능 분석의 정량화 값을 나타낸 히트맵 표(heatmap table)이다. 추가적으로, 도 17은 감염된 U2OS 및 SaOS2 세포에 대하여 세포 생존능 분석의 정량화 값을 나타낸 표를 제공한다. U2OS 및 SaOS2 세포 모두는 골세포종(osteocarcinoma) 세포이다; 그러나, p53 및 Rb는 U2OS 세포에서 기능적이지만, SaOS2 세포에서 변이되어 있다. 상기 결과는 돌연변이 바이러스가 Rb-결함 종양 세포에서 선별적으로 복제하는 것을 나타낸다.
상기 데이타는 E1A, E4orf1 및/또는 E4orf6/7의 다양한 변형의 조합이 Rb 종양 억제인자 경로의 결함을 가진 가진 암세포에서 특이적으로 복제하는 선별적 종양 살상 아데노바이러스를 만들어낼 수 있음을 보여준다.
실시예 2: E1, L3, E3 및/또는 E4에서 변형을 가진 종양 살상 아데노바 이러스
이 실시예는 종양 선별력을 가지는 추가 재조합 아데노바이러스를 기술한다. 전형적 재조합 바이러스는 표 2에 열거되었고 이들 바이러스의 게놈 서열은 서열번호 25-31로 기재되었다.
표 2. E1, L3, E3 및/또는 E4에서 변형을 가진 아데노바이러스
바이러스 명칭
(서열변호) 		E1 L3 E3 E4
AdSyn-CO312
(25)		 E1A ΔLXCXE wt
 ΔE3-RIDα/β, ΔE3-14.7k
+EGFRVHH-FKBP
FRB*-섬유		 ΔE4orf6/7
AdSyn-CO313
(26)		 E1A ΔLXCXE wt ΔE3-RIDα/β, ΔE3-14.7k
+EGFRVHH-FKBP
FRB-섬유		 ΔE4orf6/7
AdSyn-CO199
(27)		 ΔE1 +EF1α-루시퍼라제 wt wt wt
AdSyn-CO200
(28)		 ΔE1 +EF1α-루시퍼라제-miR122 wt wt wt
AdSyn-CO171
(29)		 ΔE1 +EF1α-루시퍼라제-miR122 헥손 E451Q wt wt
AdSyn-CO335
(30)		 E1A ΔLXCXE 헥손 E451Q ΔE3-RIDα/β, ΔE3-14.7k +EGFRVHH-FKBP
FRB*-섬유		 ΔE4orf6/7
AdSyn-CO442
(31)		 E1A ΔLXCXE 헥손 E451Q FRB*-섬유 ΔE4orf6/7
AdSyn-CO440
(68)		 E1B-55k-P2A-Ypet wt ΔE3-RIDα/β, ΔE3-14.7k +EGFRVHH-GS-FKBP-P2A-ADP
FRB-섬유		 wt
AdSyn-CO312, AdSyn-CO313 및 AdSyn-CO335은 라파마이신- 및/또는 라파로그(rapalog, AP21967)-의존적 EFGR-표적화된 바이러스이다(표적화 방법의 설명을 위하여, 참조로 본 명세서에 참조문헌으로 삽입된 PCT 공개번호 WO 2013/138505을 참조). 상기 재조합 바이러스의 각각은 E3-RIDα/β 및 E3-14.7k 코딩 서열의 결실, 및 FRB*-섬유(라파마이신 또는 라파로그에 결합할 수 있는 돌연변이 FRB에 융합된 Ad5 섬유) 또는 FRB-섬유(단지 라파마이신에 결합할 수 있는 야생형 FRB에 결합된 Ad5 섬유)의 어느 하나와 EGFRVHH-FKBP 융합 단백질의 삽입을 포함한다. AdSyn-CO442은 라파마이신/라파로그-의존적 재표적화에 필요한, FKBP 융합 단백질이 아닌, FRB*-섬유를 발현하기 때문에, 실험 대조군 바이러스(experimental control virus)로서 사용될 수 있다. 또한, AdSyn-CO335 및 AdSyn-CO442은 헥손 단백질에서 E451Q 돌연변이를 포함한다. 이 돌연변이는 재조합 바이러스를 간으로 비표적화한다.
도 18A은 라파마이신을 가진 FRB 도메인과 FKBP12의 결합 경계면을 나타낸다. 도 18B은 FRB-섬유(AdSyn-CO205; 서열번호 88)을 가진 EGFR-표적화 바이러스는 AP21967가 아닌, 라파마이신이 존재할 때 MDA MB 453 유방암 세포로의 형질도입이 향상되고, 반면, FRB*-섬유(AdSyn-CO220; 서열번호 98)을 가진 EGFR-표적화 바이러스는 라파마이신 또는 AP21967의 존재에서 MDA MB 453 세포로의 형질도입의 향상을 나타내는 그래프이다. 도 18C는 mTOR체의 표적 p70 S6K의 인산화를 차단하는 mTOR 저해제 라파마이신의 활성을 나타내는 면역블롯이다. 라파마이신 동족체(homolog) AP21967는 표적화 농도에서 mTOR를 저해하지 않는다.
AdSyn-CO312을 HS578T 전이성 유방암 세포에서 테스트하였다. 감염 후 24, 48, 72 및 96 시간에, 신선한 라파마이신 또는 AP21967을 50 nM로 첨가하였다. 대사 활성을 WST-1 분석으로 정량화하고, 상응하는 약물을 처리한 비감염된 세포로 정규화(normalization)하였다. 도 18D에 나타낸 바와 같이, AdSyn-CO312의 감염은 표적의 부재와 비교하여 라파마이신 또는 AP21967가 처리된 EGFR-표적화 종양 살상 바이러스로 감염된 세포의 증강된 세포 살상을 초래한다. 감염 9일 후에 AdSyn-CO313-감염된 HS578T 전이성 유방암 세포의 세포 생존능을 도 18E에 나타냈다. 세포를 AdSyn-CO313의 연속 희석을 통해 감염시켰다. 감염 후 24, 48, 72 및 96 시간째에, 신선한 라파마이신을 50 nM로 첨가하였다. 대사 활성을 WST-1 분석으로 정량화하고, 상응하는 약물을 처리한 비감염된 세포로 정규화(normalization)하였다. AdSyn-CO313은 E1A ΔLXCXE, ΔE4orf6/7, ΔE3-RIDα/β, ΔE3-14.7k의 종양 살상 돌연변이를 가지고 있고 라파마이신-의존성 EGFR-표적화 유전자 EGFRVHH-FKBP 및 FRB-섬유를 발현한다. 표적화없이도 라파마이신이 처리된 EGFR-표적화 종양 살상 바이러스로 감염된 세포의 증강된 살상이 있다.
AdSyn-CO313은 HS578T를 피하 이종이식한 마우스에서 평가하였다. 종양을 가진 마우스에 AdSyn-CO313를 종양내로 주입하고, 이후 주기적으로 복강 내 8 mg/kg 라파마이신(n=5) 또는 비히클 대조군(n=4)을 투여하거나, 또는 종양내 비히클 대조군을 주입하고, 후속적으로 주기적 복강 내 8 mg/kg 라파마이신 주사 (n=5) 또는 비히클 대조군 (n=4)을 투여하였다. 감염은 초기 감염 이후 19일째에 시작해서 매 4 일마다 3회 동일한 군에 되풀이하였다. 도 19에 나타낸 바와 같이, 라파마이신과 함께 EGFR-표적화 종양 살상 바이러스가 투여된 마우스의 종양은 가장 좋은 반응을 나타냈다.
AdSyn-CO335은 헥손 E451Q 돌연변이에 의해 간 흡수를 회피하는 캡시드(capsid)를 특징으로 하는 종양 살상 바이러스이고, 라파마이신 또는 라파로그 AP21967 존재에서 EGFR을 통해 세포를 감염시키도록 표적화될 수 있다. AdSyn-CO335의 종양 살상 활성을 시험관 내 및 생체 내에서 테스트하였다. HS578T 세포를 AdSyn-CO335의 연속 희석을 통해 감염시켰다. 감염 후 24, 48, 72 및 96시간째에, 신선한 라파마이신 또는 AP21967를 50 nM로 첨가하였다. 대사 활성을 WST-1 분석으로 정량화하고, 상응하는 약물을 처리한 비감염된 세포로 정규화(normalization)하였다. 도 20에 나타낸 바와 같이, 표적화없이 감염된 세포와 비교하여, EGFR-표적화 종양 살상 바이러스로 감염된 라파마이신 또는 AP21967이 처리된 세포에서 증강된 세포사멸이 있다. 생체 내 AdSyn-CO335를 평가하기 위하여, 마우스에 HS578T 피하 이종이식을 마우스에 수행하였다. 종양을 가진 마우스는 4 일마다 AdSyn-CO335의 3회 종양내 주사를 받은 후, 이후 격일로 복강 내로 2 또는 8 mg/kg 라파마이신 (각각, n=8 및 n=8) 또는 비히클 대조군 (n=6)을 투여받거나; 또는 종양을 가진 마우스를 4 일마다 AdSyn-CO442의 3회 종양내 주사를 받은 후, 이후 격일로 복강 내로 2 또는 8 mg/kg 라파마이신 (각각, n=6 및 n=6)를 받거나; 또는 종양을 가진 마우스를 4일마다 비히클 대조군의 3회 종양내 주사를 받은 후, 이후 격일로 복강 내 2 또는 8 mg/kg 라파마이신(각각, n=6 및 n=6)를 투여받았다. 도 21A-21D에 나타낸 바와 같이, 8 mg/kg 라파마이신과 같이 EGFR-표적화 종양 살상 바이러스를 받은 마우스의 종양은 가잘 현저한 반응을 나타낸다.
AdSyn-CO199, AdSyn-CO200 및 AdSyn-CO171은 E1A 결실을 가지고 EF1α 프로모터(EF1α-루시퍼라제)에 의해 조절되는 루시퍼라제를 암호화하는 재조합 리포터 바이러스이다. 또한 AdSyn-CO200 및 AdSyn-CO171은 간에서 바이러스 유전자 발현을 억제하기 위하여, E1A의 3'-UTR에서(간 특정 마이크로 RNA) miR-122에 대한 2개의 결합 부위를 포함한다. 추가적으로 AdSyn-CO171은 헥손 단백질의 간 비표적화 E451Q 돌연변이를 암호화한다.
도 22A-22C는 간에서 아데노바이러스 매개된 유전자 발현의 제거, 및 간으로의 아데노바이러스 감염의 비표적화를 나타낸다. AdSyn-CO199는 전신성 감염후에 오로지 간에서 높은 수준의 루시퍼라제를 발현하였다(도 22A). 도 22B에 나타낸 바와 같이, 루시퍼라제 신호는, 간-특이적 마이크로 RNA miR122가 루시퍼라제 발현을 제거하는 것을 제외하고는, 마우스가 AdSyn-CO199에 상응하는 바이러스, AdSyn-CO200으로 전신성으로 감염되었을 때 사라진다. 도 22C에 나타낸 바와 같이, 루시퍼라제 발현은, 아데노바이러스 헥손 단백질이 간으로부터 비표적화하는 돌연변이 E451Q를 가지는 것을 제외하고, 마우스가 AdSyn-CO171을 상응하는 바이러스, AdSyn-CO171로 전신성 감염될 때 비장에서 검출될 수 있다. 상기 데이타는 Ad E1 유전자의 간에서의 발현을 방지하고 간세포에서 복제를 조절하기 위한(definition replication) 게놈 모듈 변형의 유용성을 입증한다.
실시예 3: 키메라 섬유 단백질을 발현하는 재조합 아데노바이러스
하기 실시예는 특정한 세포 유형에 직접 감염하는 키메라(chimeric) 섬유 단백질을 발현하는 재조합 아데노바이러스를 설명한다.
Ad5 및 ?萱? 다른 혈청형의 섬유 단백질(fiber protein)이 세포내 부착을 위해 콕사키 아데노바이러스 수용체 (CAR)에 결합하는 것으로 알려진 반면에, 다른 혈청형은 CD46, 데스모글레인 2, 시알산, 또는 다른 것들을 이용하는 것으로 알려져 있다. Adsembly/AdSLIC(본 명세서에서 참조문헌으로 인용된, PCT 공개번호 WO 2012/024351을 참조)는 키메라 바이러스의 신속한 제조를 허용하기 때문에, 6개의 섬유 키메라 바이러스로 구성된 패널(panel)이 다양한 혈청형의 세포내 표적화 능력을 조사하기 위해서 생성되었다. 섬유 단백질의 C-말단의 글로불라 노브(globular knob)는 수용체와의 결합에 관여하기 때문에, 키메라는 Ad5 섬유 노브를 Ad3, Ad9, Ad11, Ad12, 또는 Ad34로부터의 섬유 노브로 대체하여 제조하였다(도 23A23C; 표 3). 각각의 바이러스를 E1A/E1B 결실 및 EF1α 프로모터에 의해 조절되는 루시퍼라제-GFP 융합체를 포함하는 동일한 E1 모듈로 제조되었다. 상기 패늘(panel)을 17 다른 종양세포주, 주요 기도 세포 및 H9 줄기 세포주로 형질도입하기 위해 사용하고, 루시퍼라제 발현을 각각 세포 유형에서 측정하였다(도 23D). Ad5 섬유와 비교하여, 현저하게 높은 루시퍼라제-GFP 발현을 Ad3, Ad11 또는 Ad34를 가진 키메라를 사용할 때 대부분 모든 세포에서 관찰하였다(도 23D 및 23E). 정반대로, 루시퍼라제-GFP 발현은 Ad9 또는 Ad12 섬유 키메라로 형질도입된 세포에서 거의 보편적으로 낮았다. 상기 데이타는 Ad5-기반으로 하는 벡터를 향상시키고 특정한 세포 유형으로 감염을 위한 재조합 바이러스를 최적화하기 위해서, 다른 혈청형으로부터의 변형된 부분을 조합하는 것의 강력한 유용성을 증명한다.
표 3. 키메라 섬유 단백질을 가진 재조합 아데노바이러스
바이러스 명칭
(서열변호) 		E1 L3 E3 E4
AdSyn-CO172
(69)		 ΔE1+EF1α-루시퍼라제-miR122 헥손 E451Q Ad3 노브 섬유 키메라 wt
AdSyn-CO173
(70)		 ΔE1+EF1α-루시퍼라제-miR122 헥손 E451Q Ad9 노브 섬유 키메라 wt
AdSyn-CO174
(71)		 ΔE1+EF1α-루시퍼라제-miR122 헥손 E451Q Ad11 노브 섬유 키메라 wt
AdSyn-CO175
(72)		 ΔE1+EF1α-루시퍼라제-miR122 헥손 E451Q Ad12 노브 섬유 키메라 wt
AdSyn-CO176
(73)		 ΔE1+EF1α-루시퍼라제-miR122 헥손 E451Q Ad34 노브 섬유 키메라 wt
실시예 4: 캡시드 ( capsid )-교환된 재조합 아데노바이러스
하기의 실시예는 캡시드(capsid)-교환된 키메라 아데노바이러스를 만들기 위한 모듈 변형을 설명한다. 실시예에서 설명된 재조합 아데노바이러스는 존재하는 중화 항체를 회피하기 위해 디자인되었다.
인간 집단에 존재하는 항체로부터 ‘보이지 않는(invisible)’효과를 제공하고, Adsembly/AdSLIC의 반복된 접종이 가능한 완전환‘캡시드(capsid)’ 모듈 교환(거의 60% 의 게놈)을 완성한 Ad5-기반으로 하는 바이러스는 아데노바이러스 게놈에 존재하는 모듈성(modularity)을 이용하도록 디자인되었다. 상기 모듈성의 가장 팔팔한 테스트는 하나의 혈청형의 전체 모듈을 다른 혈청형의 전체 모듈과 결합하는 것일 수 있다. 이러한 가능성은 Ad5의 E1, E3, 및 E4 모듈을 다른 혈청형의 코어 모듈(즉, E2B, L1, L2, L3, E2A 및 L4; 도 24A 참조)과 결합함으로써 조사되었다. 이는 중화효과를 나타내는 Ad5 항체를 회피할 수 있는 바이러스를 생산하나, 종양 살상 바이러스를 제조할 때 빈번히 변이되는 Ad5의 잘 분석되어 있는 비-구조적 유전자를 유지한다. AdSLIC는 Ad3, Ad9, Ad11, Ad12, Ad34 또는 Ad5의 E1, E3, 및 E4 모듈을 가지는 마우스 아데노바이러스 1 (MAV-1)의 코어 모듈이 포함된 바이러스를 생성하는데 사용었다(도 24B 및 표 4). 추가적으로, Ad5 E1 모듈은 Ad5의 pIX 코딩 영역을 상응하는 코어 혈청형의 pIX 코딩 영역으로 치환 변경되었고; 및 Ad5 E3 모듈은 U엑손 및 섬유 코딩 영역을 상응하는 코어 혈청형의 것으로 치환 변형되었다. 따라서, 모든 캡시드(capsid) 성분은 하나의 혈청형으로부터인 반면, 게놈의 E1, E3, 및 E4 영역은 Ad5로부터이다. 만들어진 6개의 키메라 중 4개는 293-E4 세포에서 생존가능한 바이러스를 생산할 수 있다. Ad5와 Ad3, Ad9, Ad11, 또는 Ad34 사이의 키메라는 모두 복제한 반면, Ad5/Ad12 또는 Ad5/MAV-1 키메라는 ITRs 및 코어 혈청형의 포장 서열 (Ψ)을 포함하도록 추가 변형된 후에도 복제하지 않았다(도 24B). 따라서, 상기 “캡시드-교환된” 아데노바이러스 키메라를 생성하기 위한 능력은 혈청형에 따라 다양하다.
표 4. 캡시드(capsid) 교환을 가진 재조합 아데노바이러스
바이러스 명칭
(서열변호) 		E1 코어 E3 E4
AdSyn-CO159
(74)		 Ad11 pIX All Ad11 Ad11 U엑손 및 섬유 wt
AdSyn-CO159X
(93)		 Ad11 pIX
E1A ΔLXCXE		 All Ad11 Ad11 U엑손 및 섬유 ΔE4orf6/7
AdSyn-CO167
(75)		 Ad9 pIX All Ad9 Ad9 U엑손 및 섬유 wt
AdSyn-CO167X
(94)		 Ad9 pIX
E1A ΔLXCXE		 All Ad9 Ad9 U엑손 및 섬유 ΔE4orf6/7
AdSyn-CO168
(76)		 Ad12 pIX All Ad12 Ad12 U엑손 및 섬유 wt
AdSyn-CO201
(77)		 Ad3 pIX All Ad3 Ad3 U엑손 및 섬유 wt
AdSyn-CO201X
(95)		 Ad3 pIX
E1A ΔLXCXE		 All Ad3 Ad3 U엑손 및 섬유 ΔE4orf6/7
AdSyn-CO202
(78)		 Ad34 pIX All Ad34 Ad34 U엑손 및 섬유 wt
AdSyn-CO202X
(96)		 Ad34 pIX
ΔE1A ΔLXCXE		 All Ad34 Ad34 U엑손 및 섬유 ΔE4orf6/7
AdSyn-CO185
(79)		 MAV-1 pIX
E1 +CMV-GFP		 All MAV-1 MAV-1 U엑손 및 섬유 wt
AdSyn-CO254
(80)		 Ad12 ITR/ψ, Ad12 pIX All Ad12 Ad12 U엑손 및 섬유 Ad12 ITR
AdSyn-CO255
(81)		 MAV-1 ITR/ψ, MAV-1 pIX
ΔE1 +CMV-GFP		 All MAV-1 MAV-1 U엑손 및 섬유 MAV-1 ITR
생존한 캡시드(capsid) 교환된 키메라 바이러스의 복제 및 유전자 발현을 후속적으로 분석하였다. 정제된 캡시드(capsid) 교환된 입자는 상응하는 코어 모듈을 가진 야생형 아데노바이러스 혈청형과 동일한 총 단백질 함량을 나타냈다(도 25A). 대다수의 중화 항체의 표적인 헥손 단백질은 Ad5 입자에 대하여 생성된 다클론 래빗 항혈청에 의해 다른 혈청형 또는 캡시드 교환된 바이러스에서 인식되지 않았다(도 25A). V 및 VI와 같은 캡시드의 내부에서 발견된 다른 구조적인 단백질은 일부 교차 반응성(cross reactivity)을 나타낸다(도 25A). 감염된 세포의 웨스턴 블랏 분석은, Ad5/Ad3, Ad5/Ad11, 및 Ad5/Ad34 키메라에 대하여, 교차 반응하는 후기(late) 단백질 및 100K의 발현이 A549 세포에서 야생형 Ad3, Ad11, 및 Ad34와 동일한 반면, U2OS 세포에서는 약간 높은 것을 나타냈다(도 25B, 25D 및 25E). 모든 바이러스에서 Ad5로부터 유래된 E1A의 발현은, 아마도 Ad5에 대한 향상된 세포내 침투(entry)에 기인하여, 상기 3개의 키메라에서 야생형 Ad5보다 현저하게 높았다(도 25B, 25D 및 25E 및 도 23D). 정반대로, Ad5/Ad9 캡시드 교환된 키메라는, 야생형 Ad9(late 단백질에 대하여)보다 약간 나쁘게 야생형 Ad5보다 나쁘고(E1A에 대하여), 동일한 MOI에서 낮은 유전자 발현을 나타냈다(도 25C).
다음으로, 캡시드 교환된 키메라 바이러스가 Ad5 중화 항체를 포함하는 인간 혈청 시료에서 항체 중화를 회피할 수 있는지를 테스트하였다. 인간 혈청 시료는 WST-1 세포 생존능 분석을 사용하여 측정된 바와 같이, Ad5에 의한 A549 세포의 살상을 중화시길수 있음이 확인되었다. Ad5 또는 캡시드 교환된 키메라와 상기 혈청 시료를 배양했을 때, Ad5에 의한 세포 사멸은 억제된 반면, 캡시드 교환된 바이러스에 의한 살상은 영향을 받지 않았다(도 26A-26C). 상기 데이타는 캡시드 교환된 키메라 바이러스는 인간 시료에서 통상적으로 발견되는 기존의 Ad5 항체를 회피할 수 있다는 것과 Ad5의 비-구조적 성분 및 비-Ad5의 구조적 성분의 발현과 함께 복제할 수 있다는 것을 나타낸다. 따라서, 아데노바이러스 게놈 내에서 관찰된 천연 모듈성은 유용한 성질을 가진 신규 바이러스를 만들기 위하여 Adsembly/AdSLIC를 사용하여 개발될 수 있다.
상기 논의된 바와 같이, 인간 집단의 상당비율은 Ad5 및 일부 다른 통상 아데노바이러스 혈청형에 대해 항체를 가진다. 16명의 인간 혈청 시료의 분석은 16개의 시료 중 9개가 Ad5에 대한 중화 항체를 포함하고 있음을 나타냈다. 따라서, 기존의 중화 항체를 회피할 수 있는 캡시드 교환을 가진 종양 살상 바이러스가 개발되었다. E1A(ΔLXCXE) 및 E4(ΔE4orf6/7)에 종양 살상 돌연변이가 포함된 4개의 재조합, 캡시드-교환된 아데노바이러스가 제조되었다. 상기 돌연변이는 AdSyn-CO181에 존재하는 것과 동일한 종양 살상 돌연변이이다. AdSyn-CO 159X(서열번호 93), AdSyn-CO-167X(서열번호 94), AdSyn-CO201X(서열번호 95) 및 AdSyn-CO202X(서열번호 96)는 각각 Ad11, Ad9, Ad3 및 Ad34로부터의 구조적 단백질을 포함한다.
실시예 5: 변형된 또는 키메라 섬유 단백질, 또는 캡시드 ( capsid ) 돌연변이 또는 혈청형 교환을 결합시킨 재조합 종양 살상 아데노바이러스
본 실시예는 종양 선별력, 및/또는 특정한 세포 유형으로 직접적 감염을 가능하게 하는 돌연변이 또는 키메라 섬유 단백질을 발현하는, 및/또는 중화 항체를 회피하기 위해 디자인된 캡시드-변형되거나 또는 교환된 키메라 아데노바이러스를 가진 추가 재조합 아데노바이러스를 설명한다. 대표적 재조합 바이러스를 표 5에 열거하고 이들 바이러스의 게놈 서열은 서열변호 82-87로 기재하였다.
표 5. 변형된 또는 키메라 섬유 단백질, 또는 캡시드 돌연변이 또는 혈청형 교환을 결합시킨 재조합 종양 살상 아데노바이러스
바이러스 명칭
(서열변호) 		E1 코어 E3 E4
AdSyn-CO507
(82)		 E1A ΔLXCXE 헥손 E451Q Ad34 노브 섬유 키메라 ΔE4orf6/7
AdSyn-CO508
(83)		 E1A ΔLXCXE 헥손 E451Q Ad11 노브 섬유 키메라 ΔE4orf6/7
AdSyn-CO509
(84)		 E1A ΔLXCXE 헥손 E451Q Ad37 노브 섬유 키메라 ΔE4orf6/7
AdSyn-CO510
(85)		 E1A
ΔLXCXE/Ad34 pIX		 모든 Ad34 Ad34 U엑손 및 섬유 ΔE4orf6/7
AdSyn-CO511
(86)		 E1A ΔLXCXE 헥손 E451Q/펜톤 RGE ΔE3-RIDα/β, ΔE3-14.7k
+EGFRVHH-FKBP
FRB*-섬유		 ΔE4orf6/7
AdSyn-CO512
(87)		 E1A ΔLXCXE 헥손 E451Q/펜톤 RGE 섬유 HI 루프에 있는 RGD-4C ΔE4orf6/7
여기에(표 1-4 참조) 개시된 각각의 재조합 아데노바이러스는 존재하는 중화 항체를 회피하고 특정한 세포 유형으로 감염을 유도하는데 유리한 변형을 가진다. 실시예 1에서 설명된 E1 및 E4 돌연변이는 종양 살상 바이러스 치료의 효능을 강화시키기 위해 다른 모듈과 결합될 수 있다.
키메라 섬유와 같이 E1, 코어, 및 E4 돌연변이를 가진 재조합 종양 살상 아데노바이러스의 예는 각각 d34, Ad11, 및 Ad37 섬유 단백질의 노브(knob) 도메인을 사용하는, AdSyn-CO507, AdSyn-CO508, 및 AdSyn-CO509가 있다.
Ad34 캡시드 교환을 함께 E1 및 E4 돌연변이를 가지는 재조합 종양 살상 아데노바이러스의 한 예는 AdSyn-CO510이다.
RGE에 대한 인테그린-결합 RGD 모티프에서 돌연변이를 가지는 캡시드 단백질 펜톤과 함께 E1, E3, 및 E4 돌연변이를 가지고, 라파마이신/라파로그 유도성 EGFR-표적화 종양 살상 아데노바이러스의 한 예는 AdSyn-CO511이다. 상기 펜톤 돌연변이는 비장에서 바이러스 흡수를 감소시키고 항바이러스 염증 반응을 약화시킨다.
섬유 단백질에서 RGD 펩티드의 삽입과 함께 E1 및 E4 돌연변이를 가진 재조합 종양 살상 아데노바이러스의 한 예는 AdSyn-CO512이다. 섬유 단백질에서 RGD 삽입은 혈관내피세포(vascular endothelial cell)를 포함하여, 넓은 다양한 세포 유형으로의 감염을 현저하게 증가시키는 것으로 확인되었다.
실시예 6: Ad5 및 다른 아데노바이러스 혈청형으로부터 유래된 종양 살상 아데노바이러스
여기에(표 1-5 참조)는 Ad5 벡터를 사용하여 개발되었다. 그러나, 아데노바이러스 복제에 중요한 많은 게놈영역(및 이 영역에서 암호화는 단백질)은 아데노바이러스 혈청형 간에 고도로 보존되었다. 따라서, 여기서 개시된 재조합 아데노바이러스는 임의의 원하는 아데노바이러스 혈청형으로부터 게놈 서열을 사용하여 생성될 수 있다. 특히, E1A 및 E4orf6/7 단백질은 모든 인간 종의 아데노바이러스 간에 보존되어 왔다. 도 27은 종(species) A (Ad12), 종 B (Ad7), 종 C (Ad2 및 Ad5), 종 D (Ad9), 종 E (Ad4), 종 F (Ad40) 및 종 G (Ad52) 아데노바이러스로부터 E1A 단백질의 정렬을 나타낸다. 유사하게, 도 28은 종 A (Ad12, 종 B (Ad7), 종 C (Ad2 및 Ad5), 종 D (Ad9), 종 E (Ad4) 및 종 G (Ad52) 아데노바이러스의 E4orf6/7 단백질들의 정렬(alignment)을 나타낸다. 도 27 및 28에 나타낸 서열, 공공 데이타베이스에서 사용가능한 임의의 다른 아데노바이러스 서열을 사용하여, 종양 살상 아데노바이러스의 생성에 임의의 아데노바이러스 혈청형 유래의 E1A 및/또는 E4orf6/7 서열을 쉽게 사용할 수 있다.
실시예 7: EGFR - 표적화 요소를 가지는 재조합 아데노바이러스 특징
본 실시예는 EGFR을 발현하는 세포로 표적화된 합성 아데노바이러스를 기술하며, 그 재조합 바이러스는 변형의 결과로서 293-E4 세포에서 복제 손상(replication implication)이 일어나지 않음을 확인한다. 하기의 합성 아데노바이러스는 본 연구에서 생성되고 사용되었다:
AdSyn -CO170 (서열번호 91)
아데노바이러스 게놈 모듈로부터 다중부위 게이트웨이® LR 재조합 반응인,“에드셈블리(Adsembly)”를 사용하여 만든 야생형 아데노바이러스. 3개의 재조합 부위는 아데노바이러스 모듈-EIB-55K 및 pIX 유전자 사이의 attB4 재조합 부위; L4-33K 및 pVIII 유전자 사이의 attB5 부위; 및 섬유 및 E4 유전자 사이의 attB3 부위-사이의 게놈에 존재한다. 상기 재조합 아데노바이러스는 대조군 바이러스로서 역할을 한다.
AdSyn -CO205 (서열번호 88)
AdSyn-CO170에 상응하지만, 라파마이신-의존적으로 표적화가 EGFR을 발현하는 세포로의 감염을 가능하게 하는 추가적 특징을 가진, Adsembly에 의해 제조된 재조합 아데노바이러스. mTOR로부터 FRB 도메인을 암호화하는 서열을 아데노바이러스 섬유의 노브 도메인의 HI 루프로 삽입된다. E3-RIDα, E3-RIDβ, 및 E3-14.7K 유전자는 제거되고, FKBP12에 융합된 EGFR-결합 단일-도메인 항체(EGFRVHH)를 암호화하는 유전자로 대체되었다. 라파마이신의 존재에서, 가용성 EGFRVHH-FKBP 융합 단백질은 섬유에서 FRB 도메인과 헤테로다이머(heterodimer)를 형성하고, 성숙한 아데노바이러스 입자가 새로운 세포 상의 EGFR에 결합하여 그 새로운 수용체를 경유하여 감염시킬 수 있도록 한다.
AdSyn -CO206 (서열번호 89)
재조합 아데노바이러스가 야생형 섬유를 가지는 것, 따라서 FRB 도메인이 없는 것을 제외하면, AdSyn-CO205와 동일하다. 상기 바이러스는 AdSyn-CO205에 설명된 바와 같이, E3-RIDα, E3-RIDβ, 및 E3-14.7K 유전자의 결실, 및 FKBP12에 융합된 EGFR-결합 단일-도메인 항체 (EGFRVHH)를 암호화하는 유전자의 치환이라는 특성을 가진다.
AdSyn -CO207 (서열번호 90)
재조합 아데노바이러스는, 야생형 E3 영역을 가지는 것, 따라서 EGFRVHH-FKBP 융합체가 없는 것을 제외하고는, AdSyn-CO205와 동일하다. AdSyn-CO205에서 설명된 바와 같이, 이것은 섬유에 FRB 삽입이라는 특징을 가진다.
AdSyn -CO220 (서열번호 98)
재조합 아데노바이러스는, 라파마이신 또는 AP21967으로 EGFR-표적화를 가능하게 하는, FRB 도메인 (FRB*)에서 T2098L 돌연변이를 가지는 것을 제외하고는, AdSyn-CO205와 동일하다.
라파마이신에 의해 조절된 EGFR-표적된 바이러스 AdSyn-CO205는, 감염의 마커로서 E1A에 융합된 GFP 리포터를 포함한다. E3B 전사체는 RIDα, RIDβ, 및 14.7k를 삭제하여 변형되고, EGFRVHH-FKBP를 발현하는데 사용된다. AdSyn-CO206은 AdSyn-CO205의 모든 변형을 가지나, 야생형 섬유를 유지하므로, FRB 도메인을 가지지 않는다. AdSyn-CO207은 AdSyn-CO206의 모든 변형을 가지나, 야생형 E3 영역을 유지하므로, FKBP-융합체 유전자를 가지지 않는다.
상기 재조합 바이러스의 Ad5 후기(late) 단백질 발현을 조사하기 위하여, 293-E4 세포를 MOI 10의“야생형” 대조군 바이러스 AdSyn-CO170, 변형된 라파마이신-의존적 EGFR-표적화 바이러스 AdSyn-CO205, 또는 대조군 바이러스 AdSyn-CO206 또는 AdSyn-CO207로 감염시켰다. 도 29는 감염된 293-E4 세포의 용해물로부터 단백질 발현의 면역블롯을 보여준다. 섬유 이동의 변화는 AdSyn-CO207 및 AdSyn-CO205에서 90개의 아미노산 FRB 도메인 삽입을 나타낸다. EGFRVHH-FKBP 융합 단백질의 발현을 FKBP12에 대한 프로빙(probing)으로 검출하였다. 시간경과에 따른 후기(late) 단백질 발현 결과는 Adsembly 야생형 AdSyn-CO170와 비교하여 캡시드-돌연변이, 또는 GFP-E1A 리포터를 가진 바이러스를 발현하는 EGFRVHH-FKBP의 복제에서 확연한 결함이 없음을 보여준다.
실시예 8: AdSyn -CO335의 라파마이신 -유도된 EGFR - 표적화는 마우스에서 HS578T 이종이식의 종양 살상 치료의 효능을 증가시킨다
본 실시예는 재조합 아데노바이러스의 라파마이신-의존적 EGFR 재표적화가 EGFR-발현하는 종양 이종이식의 종양 부피를 현저하게 감소시키는 사실을 설명한다.
마우스 및 종양
HS578T (ATCC-HTB-126; American Type Culture Collection, Manassas, CA) 유방암 세포는 공급자의 권고한대로 배양되었다. 암컷 5-주령 아쓰믹(arthymic) 마우스(J:NU #007850; Jackson Laboratory, Bar Harbor, ME)를 승인된 프로토콜하에서 사육하였다. 이종이식을 마취 상태(Isoflurane)에서 왼쪽 및 오른쪽 옆구리로 HS578T 세포(5E6 세포 0.2 ㎖의 BD Matrigel Matrix에 현탁); BD Biosciences, Bedford, MA)를 피하 주입하여 개시하였다.
2개의 수직의 종양 지름(l 및 w)을 종양 진행을 따라 매주 측정하였다. 종양 부피를 변형된 타원체 식 vol = 1/2(l * w 2)을 사용하여 계산하였다(Euhus et al., J Surg Oncol 31(4):229-2341986; Tomayko et al., Cancer Chemother Pharmacol 24(3):148-154, 1989).
이식 후 2개월째에, 270±17 mm3 (평균±SEM)의 부피를 가진 86개의 종양을 가진 48 마리 마우스를 본 연구분석에 포함하였고 유사한 평균-크기 종양(n=6 내지 8)을 가진 치료군들로 무작위로 분류하였다. HS578T의 모든 주입이 종양을 발생시키지는 않았다. 0, 3, 및 6일째에 마우스를 50 ㎕ PBS로 희석된 2 x 108 PFU의 아데노바이러스는 마우스의 종양내로 투여되었다. AdSyn-CO335은 FRB 서열을 가진 섬유 단백질을 발현하고 EGFR(EGFRVHH)를 인식하는 나노체(nanobody)에 융합된 FKBP를 발현하는 종양 살상 아데노바이러스이다. AdSyn-CO442는 AdSyn-CO335의 모든 특성을 가지고 있으나, EGFRVHH를 발현하지 않는다. 100 ㎕의 5% 트윈 80/5% PEG400에 희석된 라파마이신 (Lot ASC-127; LC Laboratories, Woburn, MA)을 2 또는 8 mg/kg 복용량으로 1, 4, 7일째에 복강내로 이후 격일로 복강 내 주사되었다. 독성에 대하여 체중을 모니터링하고, 치료군에 대하여 블라인드로 종양 크기를 측정하였다. 종양이 임의의 치수(dimenssion)에서 20 mm 이상 되거나 또는 현저한 종양 부하(tumor burden)의 다른 징후를 나타내면 마우스를 희생시켰다.
통계 분석
통계 분석을 통계방법의 NIST/SEMATECH e-핸드북의 지침대로 R 통계 소프트웨어 3.2.0(The R Foundation, Vienna, Austria)를 사용하여 수행하였다. 이상값(outliei)은 Q-Q 플롯(plot)에 의해 시각적으로 검증된 정규 분포를 가정하고 95% 신뢰 구간에서 ESD(extream studentized deviate) 과정을 사용하여 확인되었다. 각 시점에서 수집된 치료군의 평균 종양 부피간의 차이정도는 분산 분석(ANOVA)를 이용하여 분석하였다.
결과
생체 내 종양을 치료하기 위한 EGFR을 통한 아데노 바이러스 자손의 표적화 정도를 확인하기 위해, 피하 HS578T 이종이식이 nu/nu 마우스의 양쪽 옆구리에 수행되었다. 종양이 264±16 mm3 (평균 ± SEM)에 도달했을 때, 마우스는 비슷한 평균 크기의 종양을 가진 치료 군들으로 무작위로 분류되었다. 마우스는 조양내로 mock(단지 비히클), AdSyn-CO335 또는 AdSyn-CO442를 투여받았다. AdSyn-CO442는 AdSyn-CO335의 특성을 가지나, EGFRVHH-FKBP를 발현하지 않는 대조군 바이러스이다. 바이러스 자손의 EGFR-표적화를 위하여 치료 과정 기간에 격일로 라파마이신(rap)을 공동-투여하였다. 결과를 도 30에 나타냈다.
mock 처리 및(n = 8 종양) 라파마이신 무처리군에서, 종양은 mock 처리시작 후 28일째에 1300 ± 448 mm3 평균 종양 부피로 자랐으며, 이후, 큰 종양 치수 때문에 마우스를 희생하였다. 비교를 위해, 하기에 기술된 데이터는 치료 과정에서 이 시점 이후 부터이다.
아데노바이러스 투여와 함께 격일로 8 mg/kg 라파마이신의 용량을 처음 테스트하였으나, 높은 라파마이신 농도는 바이러스 감염에 대한 효능을 상쇄시켰다. 8 mg/kg 라파마이신 단독 투여(바이러스 감염 없음)는 비처리(P = 4.50 x 10-2)한 것과 비교하여 종양 생장 정도를 늦추는데, 229 ± 49 mm3의 평균 종양 부피를 초래하였다. 2 mg/kg 라파마이신 단독(n = 8)의 투여는 종양 성장을 차단하는데 충분하지 않았다(P=0.144).
종양 살상 AdSyn-CO335 단독(n = 11)은 비치료와 비교하여 종양 성장의 비율에 영향을 주지 않았고, 948 ± 207 mm3의 평균 종양 부피를 나타냈다. 이는 비표적화된 AdSyn-CO335 자손에 의해 HS578T 감염의 제한에 기인한 것 같다. AdSyn-CO335 및 2 mg/kg 라파마이신 모두가 공동-투여되었을 때(n = 11), 바이러스 단독(P = 8.54 x 10-4) 또는 2 mg/kg 라파마이신 (P = 1.49 x 10-2) 치료 단독과 비교하여 종양 부피에서 급격하고 현저한 감소가 있었고, 133 ± 22 mm3의 감소된 평균 종양 부피를 나타냈다. 2 mg/kg 라파마이신 및 대조군 바이러스 AdSyn-CO442(n = 9)는, 2 mg/kg 라파마이신 치료 단독과 비교하여 평균 종양 부피의 현저한 (P = 0.449) 차이를 가지지 않고, 2 mg/kg 라파마이신 및 AdSyn-CO335의 공동 투여보다 현저한(P = 4.92 x 10-3) 거대 종양을 나타내는, 401 ± 89 mm3의 평균 종양 부피를 초래하기 때문에, 상기 데이타는 종양 부피의 감소가 바이러스 자손의 라파마이신-유도된 EGFR-표적화를 의존된다는 것을 제시한다.
2 mg/kg 라파마이신 치료와 2 mg/kg 라파마이신 및 AdSyn-CO335의 공동-투여 사이의 현저한 차이는 치료 시작 후 빠르면 14 일에 측정되었다(P = 2.25 x 10-2). 상기 시작점에서, AdSyn-CO442로 감염된 라파마이신-처리된 종양은 AdSyn-CO335-감염된 종양보다 더 자랐다(P = 1.54 x 10-2).
본 연구는 아데노바이러스 재표적에 충분한 라파마이신 용량이 면역 억제인지를 평가하기 위하여 수행되었다. 피하 HS578T 이종이식 종양을 가진 마우스는 100 ㎕ 비히클, 2 mg/kg 라파마이신 또는 8 mg/kg 라파마이신의 복강 내 주사로 처리되었다. 주사 후 1 시간에, 이종이식 조직을 수득하고, 10% 포르말린으로 고정하고, P70S6K의 인산화-T378 형태를 인식하는 항체로 IHC 염색을 위해 섹션하였다. 도 31은 트레오닌 389에서 인산화된 P70S6K(P70S6K p-T389)에 대하여 염색된 HS578T 이종이식 조직 섹션의 미세사진(micropictographs)을 나타낸다. T389에서 P70S6K의 인산화는 mTOR 활성의 특징이다. 비처리 또는 낮은, 아데노바이러스 EGFR-표적화 유효량(2 mg/kg)으로 처리된 조직에서, P70S6K p-T389의 염색으로 입증된 바와 같이, mTOR 활성은 억제되지 않았다. 더 높은 아데노바이러스 EGFR-표적화 유효량(8 mg/kg)에서, P70S6K p-T389 염색 손실이 입증하는 바와 같이, mTOR 활성이 억제되었다. 상기 결과는 생체 내 재조합 아데노바이러스의 EGFR-표적화에 충분한 라파마이신 용량이 mTOR를 억제하지 않는다는 것을 나타낸다(따라서 대체적으로 면역억제가 아니다)
실시예 9: Ad34 캡시드를 가진 재조합 종양 살상 아데노바이러스
AdSLIC에 만들어진 아데노바이러스, AdSyn-CO335B-K (서열번호 92)는 Ad5의 모든 구조적 단백질이 Ad34 구조적 단백질로 대체되는 것을 제외하고, AdSyn-CO335 (서열번호 30)와 동일하다. 이러한 바이러스는 AdSyn-CO202처럼 동일한 캡시드(capsid) 교환을 가진다. 이는 바이러스가 AdSyn-CO335의 종양 살상 선별력을 유지하는 것을 허용하나, Ad5가 항체를 중화시키는 것은 회피한다. Ad34 섬유 노브 도메인은 Ad5 섬유 노브로 대체되었고, 노브 도메인의 HI 루프로 삽입된 mTOR로부터의 FRB 도메인을 암호화하는 서열을 가진다. 3-RIDα, E3-RIDβ, 및 E3-14.7K 유전자를 제거하고, FKBP12에 융합된 EGFR-결합 단일-도메인 항체(EGFRVHH)을 암호화하는 유전자로 대체되었다. 라파마이신의 존재하에서, 가용성 EGFRVHH-FKBP 융합 단백질은 섬유에서 FRB 도메인을 가진 이종이량체(heterodimer)를 형성하고, 새로운 세포 상에서 EGFR에 결합하고 새로운 수용체를 통하여 감염시키는 성숙 아데노바이러스 입자를 허용한다. Ad34 섬유의 샤프트 도메인이 Ad5 샤프트에 의해 대체되는 것을 제외하고, AdSyn-CO335B-TK(서열번호 97)은 AdSyn-CO335B-K와 동일한 재조합 아데노바이러스이다.
본 개시의 원칙이 적용될 수 있는 많은 실시예의 관점에서, 설명된 실시예는 본 개시의 단지 실시예임을 인식해야만 하고 본 개시의 범위를 제한하는 것으로 간주되어서는 안된다. 다만, 본 개시의 범위는 하기의 청구항에 의해 정의된다. 따라서 우리는 이들 청구항의 범위 및 정신 내에 있는 모든 것을 청구한다.
SEQUENCE LISTING <110> SALK INSTITUTE FOR BIOLOGICAL STUDIES <120> ONCOLYTIC TUMOR VIRUSES AND METHODS OF USE <130> 7158-93694-02 <150> US 62/054,724 <151> 2014-09-24 <160> 98 <170> PatentIn version 3.5 <210> 1 <211> 35941 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO102) <400> 1 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcaagtca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaactcac agaaccctag tattcaacct 32940 gccacctccc tcccaacaca cagagtacac agtcctttct ccccggctgg ccttaaaaag 33000 catcatatca tgggtaacag acatattctt aggtgttata ttccacacgg tttcctgtcg 33060 agccaaacgc tcatcagtga tattaataaa ctccccgggc agctcactta agttcatgtc 33120 gctgtccagc tgctgagcca caggctgctg tccaacttgc ggttgcttaa cgggcggcga 33180 aggagaagtc cacgcctaca tgggggtaga gtcataatcg tgcatcagga tagggcggtg 33240 gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc tccgtcctgc aggaatacaa 33300 catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc gccttgtcct 33360 ccgggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc agcacagcac 33420 cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca tggcggggac 33480 cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc gacccctcat 33540 aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca cctcccggta 33600 ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc agctggccaa 33660 aacctgcccg ccggctatac actgcaggga accgggactg gaacaatgac agtggagagc 33720 ccaggactcg taaccatgga tcatcatgct cgtcatgata tcaatgttgg cacaacacag 33780 gcacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa ccatatccca 33840 gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac ctcgcacgta 33900 actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat cctccagtat 33960 ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg gagtgcgccg 34020 agacaaccga gatcgtgttg gtcgtagtgt catgccaaat ggaacgccgg acgtagtcat 34080 atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc cggtctcgcc 34140 gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca tccaggcgcc 34200 ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata acatccacca 34260 ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca cacacgggag 34320 gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt atccaaaacc 34380 tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc aaactctaca 34440 gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa aaggcaaacg 34500 gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc ctctataaac 34560 attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct caatatatct 34620 ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag agcgccctcc 34680 accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca cagacctgta 34740 taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc cttcgcaggg 34800 ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc ccgccaggaa 34860 ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg ctaaccagcg 34920 tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg ctgctcaaaa 34980 aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta gtcatgctca tgcagataaa 35040 ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca aacatgtctg 35100 cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat tagaagcctg 35160 tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca tgccggcgtg 35220 accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct cggtcatgtc 35280 cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg tcagtgctaa 35340 aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca acattacagc 35400 ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac ctgaaaaacc 35460 ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg cttccacagc 35520 ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa aacaccactc 35580 gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag agcgagtata 35640 tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag aaaaccgcac 35700 gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa tcgtcacttc 35760 cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca acacatacaa 35820 gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg ccacgtcaca 35880 aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat tattgatgat 35940 g 35941 <210> 2 <211> 35662 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO210) <400> 2 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcaagtca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaacctac atgggggtag agtcataatc 32940 gtgcatcagg atagggcggt ggtgctgcag cagcgcgcga ataaactgct gccgccgccg 33000 ctccgtcctg caggaataca acatggcagt ggtctcctca gcgatgattc gcaccgcccg 33060 cagcataagg cgccttgtcc tccgggcaca gcagcgcacc ctgatctcac ttaaatcagc 33120 acagtaactg cagcacagca ccacaatatt gttcaaaatc ccacagtgca aggcgctgta 33180 tccaaagctc atggcgggga ccacagaacc cacgtggcca tcataccaca agcgcaggta 33240 gattaagtgg cgacccctca taaacacgct ggacataaac attacctctt ttggcatgtt 33300 gtaattcacc acctcccggt accatataaa cctctgatta aacatggcgc catccaccac 33360 catcctaaac cagctggcca aaacctgccc gccggctata cactgcaggg aaccgggact 33420 ggaacaatga cagtggagag cccaggactc gtaaccatgg atcatcatgc tcgtcatgat 33480 atcaatgttg gcacaacaca ggcacacgtg catacacttc ctcaggatta caagctcctc 33540 ccgcgttaga accatatccc agggaacaac ccattcctga atcagcgtaa atcccacact 33600 gcagggaaga cctcgcacgt aactcacgtt gtgcattgtc aaagtgttac attcgggcag 33660 cagcggatga tcctccagta tggtagcgcg ggtttctgtc tcaaaaggag gtagacgatc 33720 cctactgtac ggagtgcgcc gagacaaccg agatcgtgtt ggtcgtagtg tcatgccaaa 33780 tggaacgccg gacgtagtca tatttcctga agcaaaacca ggtgcgggcg tgacaaacag 33840 atctgcgtct ccggtctcgc cgcttagatc gctctgtgta gtagttgtag tatatccact 33900 ctctcaaagc atccaggcgc cccctggctt cgggttctat gtaaactcct tcatgcgccg 33960 ctgccctgat aacatccacc accgcagaat aagccacacc cagccaacct acacattcgt 34020 tctgcgagtc acacacggga ggagcgggaa gagctggaag aaccatgttt ttttttttat 34080 tccaaaagat tatccaaaac ctcaaaatga agatctatta agtgaacgcg ctcccctccg 34140 gtggcgtggt caaactctac agccaaagaa cagataatgg catttgtaag atgttgcaca 34200 atggcttcca aaaggcaaac ggccctcacg tccaagtgga cgtaaaggct aaacccttca 34260 gggtgaatct cctctataaa cattccagca ccttcaacca tgcccaaata attctcatct 34320 cgccaccttc tcaatatatc tctaagcaaa tcccgaatat taagtccggc cattgtaaaa 34380 atctgctcca gagcgccctc caccttcagc ctcaagcagc gaatcatgat tgcaaaaatt 34440 caggttcctc acagacctgt ataagattca aaagcggaac attaacaaaa ataccgcgat 34500 cccgtaggtc ccttcgcagg gccagctgaa cataatcgtg caggtctgca cggaccagcg 34560 cggccacttc cccgccagga accatgacaa aagaacccac actgattatg acacgcatac 34620 tcggagctat gctaaccagc gtagccccga tgtaagcttg ttgcatgggc ggcgatataa 34680 aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg caaaaaagaa agcacatcgt 34740 agtcatgctc atgcagataa aggcaggtaa gctccggaac caccacagaa aaagacacca 34800 tttttctctc aaacatgtct gcgggtttct gcataaacac aaaataaaat aacaaaaaaa 34860 catttaaaca ttagaagcct gtcttacaac aggaaaaaca acccttataa gcataagacg 34920 gactacggcc atgccggcgt gaccgtaaaa aaactggtca ccgtgattaa aaagcaccac 34980 cgacagctcc tcggtcatgt ccggagtcat aatgtaagac tcggtaaaca catcaggttg 35040 attcacatcg gtcagtgcta aaaagcgacc gaaatagccc gggggaatac atacccgcag 35100 gcgtagagac aacattacag cccccatagg aggtataaca aaattaatag gagagaaaaa 35160 cacataaaca cctgaaaaac cctcctgcct aggcaaaata gcaccctccc gctccagaac 35220 aacatacagc gcttccacag cggcagccat aacagtcagc cttaccagta aaaaagaaaa 35280 cctattaaaa aaacaccact cgacacggca ccagctcaat cagtcacagt gtaaaaaagg 35340 gccaagtgca gagcgagtat atataggact aaaaaatgac gtaacggtta aagtccacaa 35400 aaaacaccca gaaaaccgca cgcgaaccta cgcccagaaa cgaaagccaa aaaacccaca 35460 acttcctcaa atcgtcactt ccgttttccc acgttacgtc acttcccatt ttaagaaaac 35520 tacaattccc aacacataca agttactccg ccctaaaacc tacgtcaccc gccccgttcc 35580 cacgccccgc gccacgtcac aaactccacc ccctcattat catattggct tcaatccaaa 35640 ataaggtata ttattgatga tg 35662 <210> 3 <211> 35653 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO283) <400> 3 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcgaatca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaacctac atgggggtag agtcataatc 32940 gtgcatcagg atagggcggt ggtgctgcag cagcgcgcga ataaactgct gccgccgccg 33000 ctccgtcctg caggaataca acatggcagt ggtctcctca gcgatgattc gcaccgcccg 33060 cagcataagg cgccttgtcc tccgggcaca gcagcgcacc ctgatctcac ttaaatcagc 33120 acagtaactg cagcacagca ccacaatatt gttcaaaatc ccacagtgca aggcgctgta 33180 tccaaagctc atggcgggga ccacagaacc cacgtggcca tcataccaca agcgcaggta 33240 gattaagtgg cgacccctca taaacacgct ggacataaac attacctctt ttggcatgtt 33300 gtaattcacc acctcccggt accatataaa cctctgatta aacatggcgc catccaccac 33360 catcctaaac cagctggcca aaacctgccc gccggctata cactgcaggg aaccgggact 33420 ggaacaatga cagtggagag cccaggactc gtaaccatgg atcatcatgc tcgtcatgat 33480 atcaatgttg gcacaacaca ggcacacgtg catacacttc ctcaggatta caagctcctc 33540 ccgcgttaga accatatccc agggaacaac ccattcctga atcagcgtaa atcccacact 33600 gcagggaaga cctcgcacgt aactcacgtt gtgcattgtc aaagtgttac attcgggcag 33660 cagcggatga tcctccagta tggtagcgcg ggtttctgtc tcaaaaggag gtagacgatc 33720 cctactgtac ggagtgcgcc gagacaaccg agatcgtgtt ggtcgtagtg tcatgccaaa 33780 tggaacgccg gacgtagtca tatttcctga agcaaaacca ggtgcgggcg tgacaaacag 33840 atctgcgtct ccggtctcgc cgcttagatc gctctgtgta gtagttgtag tatatccact 33900 ctctcaaagc atccaggcgc cccctggctt cgggttctat gtaaactcct tcatgcgccg 33960 ctgccctgat aacatccacc accgcagaat aagccacacc cagccaacct acacattcgt 34020 tctgcgagtc acacacggga ggagcgggaa gagctggaag aaccatgttt ttttttttat 34080 tccaaaagat tatccaaaac ctcaaaatga agatctatta agtgaacgcg ctcccctccg 34140 gtggcgtggt caaactctac agccaaagaa cagataatgg catttgtaag atgttgcaca 34200 atggcttcca aaaggcaaac ggccctcacg tccaagtgga cgtaaaggct aaacccttca 34260 gggtgaatct cctctataaa cattccagca ccttcaacca tgcccaaata attctcatct 34320 cgccaccttc tcaatatatc tctaagcaaa tcccgaatat taagtccggc cattgtaaaa 34380 atctgctcca gagcgccctc caccttcagc ctcaagcagc gaatcatgat tgcaaaaatt 34440 caggttcctc acagacctgt ataagattca aaagcggaac attaacaaaa ataccgcgat 34500 cccgtaggtc ccttcgcagg gccagctgaa cataatcgtg caggtctgca cggaccagcg 34560 cggccacttc cccgccagga accatgacaa aagaacccac actgattatg acacgcatac 34620 tcggagctat gctaaccagc gtagccccga tgtaagcttg ttgcatgggc ggcgatataa 34680 aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg caaaaaagaa agcacatcgt 34740 agtcatgctc atgcagataa aggcaggtaa gctccggaac caccacagaa aaagacacca 34800 tttttctctc aaacatgtct gcgggtttct gcataaacac aaaataaaat aacaaaaaaa 34860 catttaagcc tgtcttacaa caggaaaaac aacccttata agcataagac ggactacggc 34920 catgccggcg tgaccgtaaa aaaactggtc accgtgatta aaaagcacca ccgacagctc 34980 ctcggtcatg tccggagtca taatgtaaga ctcggtaaac acatcaggtt gattcacatc 35040 ggtcagtgct aaaaagcgac cgaaatagcc cgggggaata catacccgca ggcgtagaga 35100 caacattaca gcccccatag gaggtataac aaaattaata ggagagaaaa acacataaac 35160 acctgaaaaa ccctcctgcc taggcaaaat agcaccctcc cgctccagaa caacatacag 35220 cgcttccaca gcggcagcca taacagtcag ccttaccagt aaaaaagaaa acctattaaa 35280 aaaacaccac tcgacacggc accagctcaa tcagtcacag tgtaaaaaag ggccaagtgc 35340 agagcgagta tatataggac taaaaaatga cgtaacggtt aaagtccaca aaaaacaccc 35400 agaaaaccgc acgcgaacct acgcccagaa acgaaagcca aaaaacccac aacttcctca 35460 aatcgtcact tccgttttcc cacgttacgt cacttcccat tttaagaaaa ctacaattcc 35520 caacacatac aagttactcc gccctaaaac ctacgtcacc cgccccgttc ccacgccccg 35580 cgccacgtca caaactccac cccctcatta tcatattggc ttcaatccaa aataaggtat 35640 attattgatg atg 35653 <210> 4 <211> 35228 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO284) <400> 4 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcgaatca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaacctac atgggggtag agtcataatc 32940 gtgcatcagg atagggcggt ggtgctgcag cagcgcgcga ataaactgct gccgccgccg 33000 ctccgtcctg caggaataca acatggcagt ggtctcctca gcgatgattc gcaccgcccg 33060 cagcataagg cgccttgtcc tccgggcaca gcagcgcacc ctgatctcac ttaaatcagc 33120 acagtaactg cagcacagca ccacaatatt gttcaaaatc ccacagtgca aggcgctgta 33180 tccaaagctc atggcgggga ccacagaacc cacgtggcca tcataccaca agcgcaggta 33240 gattaagtgg cgacccctca taaacacgct ggacataaac attacctctt ttggcatgtt 33300 gtaattcacc acctcccggt accatataaa cctctgatta aacatggcgc catccaccac 33360 catcctaaac cagctggcca aaacctgccc gccggctata cactgcaggg aaccgggact 33420 ggaacaatga cagtggagag cccaggactc gtaaccatgg atcatcatgc tcgtcatgat 33480 atcaatgttg gcacaacaca ggcacacgtg catacacttc ctcaggatta caagctcctc 33540 ccgcgttaga accatatccc agggaacaac ccattcctga atcagcgtaa atcccacact 33600 gcagggaaga cctcgcacgt aactcacgtt gtgcattgtc aaagtgttac attcgggcag 33660 cagcggatga tcctccagta tggtagcgcg ggtttctgtc tcaaaaggag gtagacgatc 33720 cctactgtac ggagtgcgcc gagacaaccg agatcgtgtt ggtcgtagtg tcatgccaaa 33780 tggaacgccg gacgtagtca tatttcctga agcaaaacca ggtgcgggcg tgacaaacag 33840 atctgcgtct ccggtctcgc cgcttagatc gctctgtgta gtagttgtag tatatccact 33900 ctctcaaagc atccaggcgc cccctggctt cgggttctat gtaaactcct tcatgcgccg 33960 ctgccctgat aacatccacc accgcagaat aagccacacc cagccaacct acacattcgt 34020 tctgcgagtc acacacggga ggagcgggaa gagctggaag aaccatgttt ttttttttat 34080 tccaaaagat tatccaaaac ctcaaaatga agatctatta agtgaacgcg ctcccctccg 34140 gtggcgtggt caaactctac agccaaagaa cagataatgg catttgtaag atgttgcaca 34200 atggcttcca aaaggcaaac ggccctcacg tccaagtgga cgtaaaggct aaacccttca 34260 gggtgaatct cctctataaa cattccagca ccttcaacca tgcccaaata attctcatct 34320 cgccaccttc tcaatatatc tctaagcaaa tcccgaatat taagtccggc cattgtaaaa 34380 atctgctcca gagcgccctc caccttcagc ctcaagcagc gaatcatgat tgcaaaaatt 34440 caggttcctc acagacctgt ataagattca aaagcggaac attaacaaaa ataccgcgat 34500 cccgtaggtc ccttcgcagg gccagctgaa cataatcgtg caggtctgca cggaccagcg 34560 cggccacttc cccgccagga accatgacaa aagaacccac actgattatg acacgcatac 34620 tcggagctat gctaaccagc gtagccccga tgtaagcttg ttgcatgggc ggcgatataa 34680 aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg caaaaaagaa agcacatcgt 34740 agtcatgctc atgcagataa aggcaggtaa gctccggaac caccacagaa aaagacacca 34800 tttttctctc aaacataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac 34860 accactcgac acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc 34920 gagtatatat aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa 34980 accgcacgcg aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg 35040 tcacttccgt tttcccacgt tacgtcactt cccattttaa gaaaactaca attcccaaca 35100 catacaagtt actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca 35160 cgtcacaaac tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat 35220 tgatgatg 35228 <210> 5 <211> 35926 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO189) <400> 5 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagca taagtgtctt gctgtcttta 4080 tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct 4140 gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag 4200 cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta 4260 gatgatccag tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa 4320 gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg 4380 gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc 4440 agccatatcc ctccggggat tcatgttgtg cagaaccacc agcacagtgt atccggtgca 4500 cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt 4560 gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc 4620 ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc 4680 gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcggta taatggttcc 4740 atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga 4800 tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg taggggagat 4860 cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta 4920 aatcacacct attaccgggt gcaactggta gttaagagag ctgcagctgc cgtcatccct 4980 gagcaggggg gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc 5040 cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa 5100 cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg 5160 gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc 5220 gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc 5280 atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc 5340 gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc 5400 tgccggtctt cgccctgcgc gtcggccagg tagcatttga ccatggtgtc atagtccagc 5460 ccctccgcgg cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg 5520 cagtgcagac ttttgagggc gtagagcttg ggcgcgagaa ataccgattc cggggagtag 5580 gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc 5640 cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt 5700 tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac 5760 ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac 5820 tctgagacaa aggctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg 5880 tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg 5940 gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg 6000 gggctataaa agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg 6060 agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga 6120 ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg 6180 agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca 6240 aacgacccgt agagggcgtt ggacagcaac ttggcgatgg agcgcagggt ttggtttttg 6300 tcgcgatcgg cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac 6360 cgccattcgg gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg 6420 ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc 6480 cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg 6540 tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct 6600 atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg 6660 tatgggttga gtgggggacc ccatggcatg gggtgggtga gcgcggaggc gtacatgccg 6720 caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt 6780 ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg 6840 ggaccgaggt tgctacgggc gggctgctct gctcggaaga ctatctgcct gaagatggca 6900 tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct 6960 accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg 7020 acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt 7080 cccttttttt tccacagctc gcggttgagg acaaactctt cgcggtcttt ccagtactct 7140 tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg 7200 gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg 7260 agcgaggtgt gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg 7320 aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa 7380 cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata 7440 aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg 7500 gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag ttccaagaag 7560 cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg 7620 gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat 7680 gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg 7740 cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag 7800 cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg 7860 ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta 7920 taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg 7980 aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag 8040 tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag 8100 cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag 8160 agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct 8220 tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc 8280 gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga 8340 tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg 8400 tttacctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg 8460 ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg 8520 gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt 8580 gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg 8640 gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg 8700 cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg 8760 tgagcttgag cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct 8820 ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact 8880 gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt 8940 cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc 9000 ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga 9060 gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg 9120 tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt 9180 tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga 9240 aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg 9300 cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct 9360 cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac 9420 ggcggcgacg acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc 9480 gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc 9540 cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc 9600 taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt 9660 ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 9720 gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg 9780 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca 9840 ccatgtcctt gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt 9900 tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt 9960 cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg 10020 gccgtaggtg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa 10080 gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg 10140 tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag 10200 tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt 10260 acctgagacg cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt 10320 actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg 10380 ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg 10440 acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc 10500 agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg gtcaggcgcg 10560 cgcaatcgtt gacgctctag accgtgcaaa aggagagcct gtaagcgggc actcttccgt 10620 ggtctggtgg ataaattcgc aagggtatca tggcggacga ccggggttcg agccccgtat 10680 ccggccgtcc gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg 10740 tcagacaacg ggggagtgct ccttttggct tccttccagg cgcggcggct gctgcgctag 10800 cttttttggc cactggccgc gcgcagcgta agcggttagg ctggaaagcg aaagcattaa 10860 gtggctcgct ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg ggacccccgg 10920 ttcgagtctc ggaccggccg gactgcggcg aacgggggtt tgcctccccg tcatgcaaga 10980 ccccgcttgc aaattcctcc ggaaacaggg acgagcccct tttttgcttt tcccagatgc 11040 atccggtgct gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc 11100 agacatgcag ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca tccgcggttg 11160 acgcggcagc agatggtgat tacgaacccc cgcggcgccg ggcccggcac tacctggact 11220 tggaggaggg cgagggcctg gcgcggctag gagcgccctc tcctgagcgg tacccaaggg 11280 tgcagctgaa gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc 11340 gcgagggaga ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc 11400 ggcatggcct gaatcgcgag cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa 11460 ccgggattag tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc gcatacgagc 11520 agacggtgaa ccaggagatt aactttcaaa aaagctttaa caaccacgtg cgtacgcttg 11580 tggcgcgcga ggaggtggct ataggactga tgcatctgtg ggactttgta agcgcgctgg 11640 agcaaaaccc aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg cagcacagca 11700 gggacaacga ggcattcagg gatgcgctgc taaacatagt agagcccgag ggccgctggc 11760 tgctcgattt gataaacatc ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg 11820 ctgacaaggt ggccgccatc aactattcca tgcttagcct gggcaagttt tacgcccgca 11880 agatatacca taccccttac gttcccatag acaaggaggt aaagatcgag gggttctaca 11940 tgcgcatggc gctgaaggtg cttaccttga gcgacgacct gggcgtttat cgcaacgagc 12000 gcatccacaa ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc 12060 acagcctgca aagggccctg gctggcacgg gcagcggcga tagagaggcc gagtcctact 12120 ttgacgcggg cgctgacctg cgctgggccc caagccgacg cgccctggag gcagctgggg 12180 ccggacctgg gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat 12240 atgacgagga cgatgagtac gagccagagg acggcgagta ctaagcggtg atgtttctga 12300 tcagatgatg caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc 12360 cggccttaac tccacggacg actggcgcca ggtcatggac cgcatcatgt cgctgactgc 12420 gcgcaatcct gacgcgttcc ggcagcagcc gcaggccaac cggctctccg caattctgga 12480 agcggtggtc ccggcgcgcg caaaccccac gcacgagaag gtgctggcga tcgtaaacgc 12540 gctggccgaa aacagggcca tccggcccga cgaggccggc ctggtctacg acgcgctgct 12600 tcagcgcgtg gctcgttaca acagcggcaa cgtgcagacc aacctggacc ggctggtggg 12660 ggatgtgcgc gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca acctgggctc 12720 catggttgca ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc ggggacagga 12780 ggactacacc aactttgtga gcgcactgcg gctaatggtg actgagacac cgcaaagtga 12840 ggtgtaccag tctgggccag actatttttt ccagaccagt agacaaggcc tgcagaccgt 12900 aaacctgagc caggctttca aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg 12960 cgaccgcgcg accgtgtcta gcttgctgac gcccaactcg cgcctgttgc tgctgctaat 13020 agcgcccttc acggacagtg gcagcgtgtc ccgggacaca tacctaggtc acttgctgac 13080 actgtaccgc gaggccatag gtcaggcgca tgtggacgag catactttcc aggagattac 13140 aagtgtcagc cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa ccctaaacta 13200 cctgctgacc aaccggcggc agaagatccc ctcgttgcac agtttaaaca gcgaggagga 13260 gcgcattttg cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg acggggtaac 13320 gcccagcgtg gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa 13380 ccggccgttt atcaaccgcc taatggacta cttgcatcgc gcggccgccg tgaaccccga 13440 gtatttcacc aatgccatct tgaacccgca ctggctaccg ccccctggtt tctacaccgg 13500 gggattcgag gtgcccgagg gtaacgatgg attcctctgg gacgacatag acgacagcgt 13560 gttttccccg caaccgcaga ccctgctaga gttgcaacag cgcgagcagg cagaggcggc 13620 gctgcgaaag gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc 13680 gcggtcagat gctagtagcc catttccaag cttgataggg tctcttacca gcactcgcac 13740 cacccgcccg cgcctgctgg gcgaggagga gtacctaaac aactcgctgc tgcagccgca 13800 gcgcgaaaaa aacctgcctc cggcatttcc caacaacggg atagagagcc tagtggacaa 13860 gatgagtaga tggaagacgt acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc 13920 cacccgtcgt caaaggcacg accgtcagcg gggtctggtg tgggaggacg atgactcggc 13980 agacgacagc agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc accttcgccc 14040 caggctgggg agaatgtttt aaaaaaaaaa aagcatgatg caaaataaaa aactcaccaa 14100 ggccatggca ccgagcgttg gttttcttgt attcccctta gtatgcggcg cgcggcgatg 14160 tatgaggaag gtcctcctcc ctcctacgag agtgtggtga gcgcggcgcc agtggcggcg 14220 gcgctgggtt ctcccttcga tgctcccctg gacccgccgt ttgtgcctcc gcggtacctg 14280 cggcctaccg gggggagaaa cagcatccgt tactctgagt tggcacccct attcgacacc 14340 acccgtgtgt acctggtgga caacaagtca acggatgtgg catccctgaa ctaccagaac 14400 gaccacagca actttctgac cacggtcatt caaaacaatg actacagccc gggggaggca 14460 agcacacaga ccatcaatct tgacgaccgg tcgcactggg gcggcgacct gaaaaccatc 14520 ctgcatacca acatgccaaa tgtgaacgag ttcatgttta ccaataagtt taaggcgcgg 14580 gtgatggtgt cgcgcttgcc tactaaggac aatcaggtgg agctgaaata cgagtgggtg 14640 gagttcacgc tgcccgaggg caactactcc gagaccatga ccatagacct tatgaacaac 14700 gcgatcgtgg agcactactt gaaagtgggc agacagaacg gggttctgga aagcgacatc 14760 ggggtaaagt ttgacacccg caacttcaga ctggggtttg accccgtcac tggtcttgtc 14820 atgcctgggg tatatacaaa cgaagccttc catccagaca tcattttgct gccaggatgc 14880 ggggtggact tcacccacag ccgcctgagc aacttgttgg gcatccgcaa gcggcaaccc 14940 ttccaggagg gctttaggat cacctacgat gatctggagg gtggtaacat tcccgcactg 15000 ttggatgtgg acgcctacca ggcgagcttg aaagatgaca ccgaacaggg cgggggtggc 15060 gcaggcggca gcaacagcag tggcagcggc gcggaagaga actccaacgc ggcagccgcg 15120 gcaatgcagc cggtggagga catgaacgat catgccattc gcggcgacac ctttgccaca 15180 cgggctgagg agaagcgcgc tgaggccgaa gcagcggccg aagctgccgc ccccgctgcg 15240 caacccgagg tcgagaagcc tcagaagaaa ccggtgatca aacccctgac agaggacagc 15300 aagaaacgca gttacaacct aataagcaat gacagcacct tcacccagta ccgcagctgg 15360 taccttgcat acaactacgg cgaccctcag accggaatcc gctcatggac cctgctttgc 15420 actcctgacg taacctgcgg ctcggagcag gtctactggt cgttgccaga catgatgcaa 15480 gaccccgtga ccttccgctc cacgcgccag atcagcaact ttccggtggt gggcgccgag 15540 ctgttgcccg tgcactccaa gagcttctac aacgaccagg ccgtctactc ccaactcatc 15600 cgccagttta cctctctgac ccacgtgttc aatcgctttc ccgagaacca gattttggcg 15660 cgcccgccag cccccaccat caccaccgtc agtgaaaacg ttcctgctct cacagatcac 15720 gggacgctac cgctgcgcaa cagcatcgga ggagtccagc gagtgaccat tactgacgcc 15780 agacgccgca cctgccccta cgtttacaag gccctgggca tagtctcgcc gcgcgtccta 15840 tcgagccgca ctttttgagc aagcatgtcc atccttatat cgcccagcaa taacacaggc 15900 tggggcctgc gcttcccaag caagatgttt ggcggggcca agaagcgctc cgaccaacac 15960 ccagtgcgcg tgcgcgggca ctaccgcgcg ccctggggcg cgcacaaacg cggccgcact 16020 gggcgcacca ccgtcgatga cgccatcgac gcggtggtgg aggaggcgcg caactacacg 16080 cccacgccgc caccagtgtc cacagtggac gcggccattc agaccgtggt gcgcggagcc 16140 cggcgctatg ctaaaatgaa gagacggcgg aggcgcgtag cacgtcgcca ccgccgccga 16200 cccggcactg ccgcccaacg cgcggcggcg gccctgctta accgcgcacg tcgcaccggc 16260 cgacgggcgg ccatgcgggc cgctcgaagg ctggccgcgg gtattgtcac tgtgcccccc 16320 aggtccaggc gacgagcggc cgccgcagca gccgcggcca ttagtgctat gactcagggt 16380 cgcaggggca acgtgtattg ggtgcgcgac tcggttagcg gcctgcgcgt gcccgtgcgc 16440 acccgccccc cgcgcaacta gattgcaaga aaaaactact tagactcgta ctgttgtatg 16500 tatccagcgg cggcggcgcg caacgaagct atgtccaagc gcaaaatcaa agaagagatg 16560 ctccaggtca tcgcgccgga gatctatggc cccccgaaga aggaagagca ggattacaag 16620 ccccgaaagc taaagcgggt caaaaagaaa aagaaagatg atgatgatga acttgacgac 16680 gaggtggaac tgctgcacgc taccgcgccc aggcgacggg tacagtggaa aggtcgacgc 16740 gtaaaacgtg ttttgcgacc cggcaccacc gtagtcttta cgcccggtga gcgctccacc 16800 cgcacctaca agcgcgtgta tgatgaggtg tacggcgacg aggacctgct tgagcaggcc 16860 aacgagcgcc tcggggagtt tgcctacgga aagcggcata aggacatgct ggcgttgccg 16920 ctggacgagg gcaacccaac acctagccta aagcccgtaa cactgcagca ggtgctgccc 16980 gcgcttgcac cgtccgaaga aaagcgcggc ctaaagcgcg agtctggtga cttggcaccc 17040 accgtgcagc tgatggtacc caagcgccag cgactggaag atgtcttgga aaaaatgacc 17100 gtggaacctg ggctggagcc cgaggtccgc gtgcggccaa tcaagcaggt ggcgccggga 17160 ctgggcgtgc agaccgtgga cgttcagata cccactacca gtagcaccag tattgccacc 17220 gccacagagg gcatggagac acaaacgtcc ccggttgcct cagcggtggc ggatgccgcg 17280 gtgcaggcgg tcgctgcggc cgcgtccaag acctctacgg aggtgcaaac ggacccgtgg 17340 atgtttcgcg tttcagcccc ccggcgcccg cgcggttcga ggaagtacgg cgccgccagc 17400 gcgctactgc ccgaatatgc cctacatcct tccattgcgc ctacccccgg ctatcgtggc 17460 tacacctacc gccccagaag acgagcaact acccgacgcc gaaccaccac tggaacccgc 17520 cgccgccgtc gccgtcgcca gcccgtgctg gccccgattt ccgtgcgcag ggtggctcgc 17580 gaaggaggca ggaccctggt gctgccaaca gcgcgctacc accccagcat cgtttaaaag 17640 ccggtctttg tggttcttgc agatatggcc ctcacctgcc gcctccgttt cccggtgccg 17700 ggattccgag gaagaatgca ccgtaggagg ggcatggccg gccacggcct gacgggcggc 17760 atgcgtcgtg cgcaccaccg gcggcggcgc gcgtcgcacc gtcgcatgcg cggcggtatc 17820 ctgcccctcc ttattccact gatcgccgcg gcgattggcg ccgtgcccgg aattgcatcc 17880 gtggccttgc aggcgcagag acactgatta aaaacaagtt gcatgtggaa aaatcaaaat 17940 aaaaagtctg gactctcacg ctcgcttggt cctgtaacta ttttgtagaa tggaagacat 18000 caactttgcg tctctggccc cgcgacacgg ctcgcgcccg ttcatgggaa actggcaaga 18060 tatcggcacc agcaatatga gcggtggcgc cttcagctgg ggctcgctgt ggagcggcat 18120 taaaaatttc ggttccaccg ttaagaacta tggcagcaag gcctggaaca gcagcacagg 18180 ccagatgctg agggataagt tgaaagagca aaatttccaa caaaaggtgg tagatggcct 18240 ggcctctggc attagcgggg tggtggacct ggccaaccag gcagtgcaaa ataagattaa 18300 cagtaagctt gatccccgcc ctcccgtaga ggagcctcca ccggccgtgg agacagtgtc 18360 tccagagggg cgtggcgaaa agcgtccgcg ccccgacagg gaagaaactc tggtgacgca 18420 aatagacgag cctccctcgt acgaggaggc actaaagcaa ggcctgccca ccacccgtcc 18480 catcgcgccc atggctaccg gagtgctggg ccagcacaca cccgtaacgc tggacctgcc 18540 tccccccgcc gacacccagc agaaacctgt gctgccaggc ccgaccgccg ttgttgtaac 18600 ccgtcctagc cgcgcgtccc tgcgccgcgc cgccagcggt ccgcgatcgt tgcggcccgt 18660 agccagtggc aactggcaaa gcacactgaa cagcatcgtg ggtctggggg tgcaatccct 18720 gaagcgccga cgatgcttct gaatagctaa cgtgtcgtat gtgtgtcatg tatgcgtcca 18780 tgtcgccgcc agaggagctg ctgagccgcc gcgcgcccgc tttccaagat ggctacccct 18840 tcgatgatgc cgcagtggtc ttacatgcac atctcgggcc aggacgcctc ggagtacctg 18900 agccccgggc tggtgcagtt tgcccgcgcc accgagacgt acttcagcct gaataacaag 18960 tttagaaacc ccacggtggc gcctacgcac gacgtgacca cagaccggtc ccagcgtttg 19020 acgctgcggt tcatccctgt ggaccgtgag gatactgcgt actcgtacaa ggcgcggttc 19080 accctagctg tgggtgataa ccgtgtgctg gacatggctt ccacgtactt tgacatccgc 19140 ggcgtgctgg acaggggccc tacttttaag ccctactctg gcactgccta caacgccctg 19200 gctcccaagg gtgccccaaa tccttgcgaa tgggatgaag ctgctactgc tcttgaaata 19260 aacctagaag aagaggacga tgacaacgaa gacgaagtag acgagcaagc tgagcagcaa 19320 aaaactcacg tatttgggca ggcgccttat tctggtataa atattacaaa ggagggtatt 19380 caaataggtg tcgaaggtca aacacctaaa tatgccgata aaacatttca acctgaacct 19440 caaataggag aatctcagtg gtacgaaact gaaattaatc atgcagctgg gagagtcctt 19500 aaaaagacta ccccaatgaa accatgttac ggttcatatg caaaacccac aaatgaaaat 19560 ggagggcaag gcattcttgt aaagcaacaa aatggaaagc tagaaagtca agtggaaatg 19620 caatttttct caactactga ggcgaccgca ggcaatggtg ataacttgac tcctaaagtg 19680 gtattgtaca gtgaagatgt agatatagaa accccagaca ctcatatttc ttacatgccc 19740 actattaagg aaggtaactc acgagaacta atgggccaac aatctatgcc caacaggcct 19800 aattacattg cttttaggga caattttatt ggtctaatgt attacaacag cacgggtaat 19860 atgggtgttc tggcgggcca agcatcgcag ttgaatgctg ttgtagattt gcaagacaga 19920 aacacagagc tttcatacca gcttttgctt gattccattg gtgatagaac caggtacttt 19980 tctatgtgga atcaggctgt tgacagctat gatccagatg ttagaattat tgaaaatcat 20040 ggaactgaag atgaacttcc aaattactgc tttccactgg gaggtgtgat taatacagag 20100 actcttacca aggtaaaacc taaaacaggt caggaaaatg gatgggaaaa agatgctaca 20160 gaattttcag ataaaaatga aataagagtt ggaaataatt ttgccatgga aatcaatcta 20220 aatgccaacc tgtggagaaa tttcctgtac tccaacatag cgctgtattt gcccgacaag 20280 ctaaagtaca gtccttccaa cgtaaaaatt tctgataacc caaacaccta cgactacatg 20340 aacaagcgag tggtggctcc cgggttagtg gactgctaca ttaaccttgg agcacgctgg 20400 tcccttgact atatggacaa cgtcaaccca tttaaccacc accgcaatgc tggcctgcgc 20460 taccgctcaa tgttgctggg caatggtcgc tatgtgccct tccacatcca ggtgcctcag 20520 aagttctttg ccattaaaaa cctccttctc ctgccgggct catacaccta cgagtggaac 20580 ttcaggaagg atgttaacat ggttctgcag agctccctag gaaatgacct aagggttgac 20640 ggagccagca ttaagtttga tagcatttgc ctttacgcca ccttcttccc catggcccac 20700 aacaccgcct ccacgcttga ggccatgctt agaaacgaca ccaacgacca gtcctttaac 20760 gactatctct ccgccgccaa catgctctac cctatacccg ccaacgctac caacgtgccc 20820 atatccatcc cctcccgcaa ctgggcggct ttccgcggct gggccttcac gcgccttaag 20880 actaaggaaa ccccatcact gggctcgggc tacgaccctt attacaccta ctctggctct 20940 ataccctacc tagatggaac cttttacctc aaccacacct ttaagaaggt ggccattacc 21000 tttgactctt ctgtcagctg gcctggcaat gaccgcctgc ttacccccaa cgagtttgaa 21060 attaagcgct cagttgacgg ggagggttac aacgttgccc agtgtaacat gaccaaagac 21120 tggttcctgg tacaaatgct agctaactac aacattggct accagggctt ctatatccca 21180 gagagctaca aggaccgcat gtactccttc tttagaaact tccagcccat gagccgtcag 21240 gtggtggatg atactaaata caaggactac caacaggtgg gcatcctaca ccaacacaac 21300 aactctggat ttgttggcta ccttgccccc accatgcgcg aaggacaggc ctaccctgct 21360 aacttcccct atccgcttat aggcaagacc gcagttgaca gcattaccca gaaaaagttt 21420 ctttgcgatc gcaccctttg gcgcatccca ttctccagta actttatgtc catgggcgca 21480 ctcacagacc tgggccaaaa ccttctctac gccaactccg cccacgcgct agacatgact 21540 tttgaggtgg atcccatgga cgagcccacc cttctttatg ttttgtttga agtctttgac 21600 gtggtccgtg tgcaccggcc gcaccgcggc gtcatcgaaa ccgtgtacct gcgcacgccc 21660 ttctcggccg gcaacgccac aacataaaga agcaagcaac atcaacaaca gctgccgcca 21720 tgggctccag tgagcaggaa ctgaaagcca ttgtcaaaga tcttggttgt gggccatatt 21780 ttttgggcac ctatgacaag cgctttccag gctttgtttc tccacacaag ctcgcctgcg 21840 ccatagtcaa tacggccggt cgcgagactg ggggcgtaca ctggatggcc tttgcctgga 21900 acccgcactc aaaaacatgc tacctctttg agccctttgg cttttctgac cagcgactca 21960 agcaggttta ccagtttgag tacgagtcac tcctgcgccg tagcgccatt gcttcttccc 22020 ccgaccgctg tataacgctg gaaaagtcca cccaaagcgt acaggggccc aactcggccg 22080 cctgtggact attctgctgc atgtttctcc acgcctttgc caactggccc caaactccca 22140 tggatcacaa ccccaccatg aaccttatta ccggggtacc caactccatg ctcaacagtc 22200 cccaggtaca gcccaccctg cgtcgcaacc aggaacagct ctacagcttc ctggagcgcc 22260 actcgcccta cttccgcagc cacagtgcgc agattaggag cgccacttct ttttgtcact 22320 tgaaaaacat gtaaaaataa tgtactagag acactttcaa taaaggcaaa tgcttttatt 22380 tgtacactct cgggtgatta tttaccccca cccttgccgt ctgcgccgtt taaaaatcaa 22440 aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga tactggtgtt 22500 tagtgctcca cttaaactca ggcacaacca tccgcggcag ctcggtgaag ttttcactcc 22560 acaggctgcg caccatcacc aacgcgttta gcaggtcggg cgccgatatc ttgaagtcgc 22620 agttggggcc tccgccctgc gcgcgcgagt tgcgatacac agggttgcag cactggaaca 22680 ctatcagcgc cgggtggtgc acgctggcca gcacgctctt gtcggagatc agatccgcgt 22740 ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt tggtagctgc cttcccaaaa 22800 agggcgcgtg cccaggcttt gagttgcact cgcaccgtag tggcatcaaa aggtgaccgt 22860 gcccggtctg ggcgttagga tacagcgcct gcataaaagc cttgatctgc ttaaaagcca 22920 cctgagcctt tgcgccttca gagaagaaca tgccgcaaga cttgccggaa aactgattgg 22980 ccggacaggc cgcgtcgtgc acgcagcacc ttgcgtcggt gttggagatc tgcaccacat 23040 ttcggcccca ccggttcttc acgatcttgg ccttgctaga ctgctccttc agcgcgcgct 23100 gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc cttatttatc ataatgcttc 23160 cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg gtgcagccac aacgcgcagc 23220 ccgtgggctc gtgatgcttg taggtcacct ctgcaaacga ctgcaggtac gcctgcagga 23280 atcgccccat catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc aacccgcggt 23340 gctcctcgtt cagccaggtc ttgcatacgg ccgccagagc ttccacttgg tcaggcagta 23400 gtttgaagtt cgcctttaga tcgttatcca cgtggtactt gtccatcagc gcgcgcgcag 23460 cctccatgcc cttctcccac gcagacacga tcggcacact cagcgggttc atcaccgtaa 23520 tttcactttc cgcttcgctg ggctcttcct cttcctcttg cgtccgcata ccacgcgcca 23580 ctgggtcgtc ttcattcagc cgccgcactg tgcgcttacc tcctttgcca tgcttgatta 23640 gcaccggtgg gttgctgaaa cccaccattt gtagcgccac atcttctctt tcttcctcgc 23700 tgtccacgat tacctctggt gatggcgggc gctcgggctt gggagaaggg cgcttctttt 23760 tcttcttggg cgcaatggcc aaatccgccg ccgaggtcga tggccgcggg ctgggtgtgc 23820 gcggcaccag cgcgtcttgt gatgagtctt cctcgtcctc ggactcgata cgccgcctca 23880 tccgcttttt tgggggcgcc cggggaggcg gcggcgacgg ggacggggac gacacgtcct 23940 ccatggttgg gggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt tcgcgctgct 24000 cctcttcccg actggccatt tccttctcct ataggcagaa aaagatcatg gagtcagtcg 24060 agaagaagga cagcctaacc gccccctctg agttcgccac caccgcctcc accgatgccg 24120 ccaacgcgcc taccaccttc cccgtcgagg cacccccgct tgaggaggag gaagtgatta 24180 tcgagcagga cccaggtttt gtaagcgaag acgacgagga ccgctcagta ccaacagagg 24240 ataaaaagca agaccaggac aacgcagagg caaacgagga acaagtcggg cggggggacg 24300 aaaggcatgg cgactaccta gatgtgggag acgacgtgct gttgaagcat ctgcagcgcc 24360 agtgcgccat tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc gccatagcgg 24420 atgtcagcct tgcctacgaa cgccacctat tctcaccgcg cgtacccccc aaacgccaag 24480 aaaacggcac atgcgagccc aacccgcgcc tcaacttcta ccccgtattt gccgtgccag 24540 aggtgcttgc cacctatcac atctttttcc aaaactgcaa gataccccta tcctgccgtg 24600 ccaaccgcag ccgagcggac aagcagctgg ccttgcggca gggcgctgtc atacctgata 24660 tcgcctcgct caacgaagtg ccaaaaatct ttgagggtct tggacgcgac gagaagcgcg 24720 cggcaaacgc tctgcaacag gaaaacagcg aaaatgaaag tcactctgga gtgttggtgg 24780 aactcgaggg tgacaacgcg cgcctagccg tactaaaacg cagcatcgag gtcacccact 24840 ttgcctaccc ggcacttaac ctacccccca aggtcatgag cacagtcatg agtgagctga 24900 tcgtgcgccg tgcgcagccc ctggagaggg atgcaaattt gcaagaacaa acagaggagg 24960 gcctacccgc agttggcgac gagcagctag cgcgctggct tcaaacgcgc gagcctgccg 25020 acttggagga gcgacgcaaa ctaatgatgg ccgcagtgct cgttaccgtg gagcttgagt 25080 gcatgcagcg gttctttgct gacccggaga tgcagcgcaa gctagaggaa acattgcact 25140 acacctttcg acagggctac gtacgccagg cctgcaagat ctccaacgtg gagctctgca 25200 acctggtctc ctaccttgga attttgcacg aaaaccgcct tgggcaaaac gtgcttcatt 25260 ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac ttatttctat 25320 gctacacctg gcagacggcc atgggcgttt ggcagcagtg cttggaggag tgcaacctca 25380 aggagctgca gaaactgcta aagcaaaact tgaaggacct atggacggcc ttcaacgagc 25440 gctccgtggc cgcgcacctg gcggacatca ttttccccga acgcctgctt aaaaccctgc 25500 aacagggtct gccagacttc accagtcaaa gcatgttgca gaactttagg aactttatcc 25560 tagagcgctc aggaatcttg cccgccacct gctgtgcact tcctagcgac tttgtgccca 25620 ttaagtaccg cgaatgccct ccgccgcttt ggggccactg ctaccttctg cagctagcca 25680 actaccttgc ctaccactct gacataatgg aagacgtgag cggtgacggt ctactggagt 25740 gtcactgtcg ctgcaaccta tgcaccccgc accgctccct ggtttgcaat tcgcagctgc 25800 ttaacgaaag tcaaattatc ggtacctttg agctgcaggg tccctcgcct gacgaaaagt 25860 ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac gtcggcttac cttcgcaaat 25920 ttgtacctga ggactaccac gcccacgaga ttaggttcta cgaagaccaa tcccgcccgc 25980 caaatgcgga gcttaccgcc tgcgtcatta cccagggcca cattcttggc caattgcaag 26040 ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg acggggggtt tacttggacc 26100 cccagtccgg cgaggagctc aacccaatcc ccccgccgcc gcagccctat cagcagcagc 26160 cgcgggccct tgcttcccag gatggcaccc aaaaagaagc tgcagctgcc gccgccaccc 26220 acggacgagg aggaatactg ggacagtcag gcagaggagg ttttggacga ggaggaggag 26280 gacatgatgg aagactggga gagcctagac gaggaagctt ccgaggtcga agaggtgtca 26340 gacgaaacac cgtcaccctc ggtcgcattc ccctcgccgg cgccccagaa atcggcaacc 26400 ggttccagca tggctacaac ctccgctcct caggcgccgc cggcactgcc cgttcgccga 26460 cccaaccgta gatgggacac cactggaacc agggccggta agtccaagca gccgccgccg 26520 ttagcccaag agcaacaaca gcgccaaggc taccgctcat ggcgcgggca caagaacgcc 26580 atagttgctt gcttgcaaga ctgtgggggc aacatctcct tcgcccgccg ctttcttctc 26640 taccatcacg gcgtggcctt cccccgtaac atcctgcatt actaccgtca tctctacagc 26700 ccatactgca ccggcggcag cggcagcggc agcaacagca gcggccacac agaagcaaag 26760 gcgaccggat agcaagactc tgacaaagcc caagaaatcc acagcggcgg cagcagcagg 26820 aggaggagcg ctgcgtctgg cgcccaacga acccgtatcg acccgcgagc ttagaaacag 26880 gatttttccc actctgtatg ctatatttca acagagcagg ggccaagaac aagagctgaa 26940 aataaaaaac aggtctctgc gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga 27000 tcagcttcgg cgcacgctgg aagacgcgga ggctctcttc agtaaatact gcgcgctgac 27060 tcttaaggac tagtttcgcg ccctttctca aatttaagcg cgaaaactac gtcatctcca 27120 gcggccacac ccggcgccag cacctgtcgt cagcgccatt tatgagcaag gaaattccca 27180 cgccctacat gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact 27240 actcaacccg aataaactac atgagcgcgg gaccccacat gatatcccgg gtcaacggaa 27300 tacgcgccca ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta 27360 ataaccttaa tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca 27420 ccactgtggt acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc 27480 agcttgcggg cggctttcgt cacagggtgc ggtcgcccgg gcagggtata actcacctga 27540 caatcagagg gcgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc 27600 gtccggacgg gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg 27660 caatcctaac tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactctgc 27720 aatttattga ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc 27780 actatccgga tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg 27840 actgaatgtt aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc 27900 gccacaagtg ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc 27960 atatcgaggg cccggcgcac ggcgtccggc ttaccgccca gggagagctt gcccgtagcc 28020 tgattcggga gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc 28080 tcactgtgat ttgcaactgt cctaaccctg gattacatca agatctttgt tgccatctct 28140 gtgctgagta taataaatac agaaattaaa atatactggg gctcctatcg ccatcctgta 28200 aacgccaccg tcttcacccg cccaagcaaa ccaaggcgaa ccttacctgg tacttttaac 28260 atctctccct ctgtgattta caacagtttc aacccagacg gagtgagtct acgagagaac 28320 ctctccgagc tcagctactc catcagaaaa aacaccaccc tccttacctg ccgggaacgt 28380 acgagtgcgt caccggccgc tgcaccacac ctaccgcctg accgtaaacc agactttttc 28440 cggacagacc tcaataactc tgtttaccag aacaggaggt gagcttagaa aacccttagg 28500 gtattaggcc aaaggcgcag ctactgtggg gtttatgaac aattcaagca actctacggg 28560 ctattctaat tcaggtttct ctagaatcgg ggttggggtt attctctgtc ttgtgattct 28620 ctttattctt atactaacgc ttctctgcct aaggctcgcc gcctgctgtg tgcacatttg 28680 catttattgt cagcttttta aacgctgggg tcgccaccca agatgattag gtacataatc 28740 ctaggtttac tcacccttgc gtcagcccac ggtaccaccc aaaaggtgga ttttaaggag 28800 ccagcctgta atgttacatt cgcagctgaa gctaatgagt gcaccactct tataaaatgc 28860 accacagaac atgaaaagct gcttattcgc cacaaaaaca aaattggcaa gtatgctgtt 28920 tatgctattt ggcagccagg tgacactaca gagtataatg ttacagtttt ccagggtaaa 28980 agtcataaaa cttttatgta tacttttcca ttttatgaaa tgtgcgacat taccatgtac 29040 atgagcaaac agtataagtt gtggccccca caaaattgtg tggaaaacac tggcactttc 29100 tgctgcactg ctatgctaat tacagtgctc gctttggtct gtaccctact ctatattaaa 29160 tacaaaagca gacgcagctt tattgaggaa aagaaaatgc cttaatttac taagttacaa 29220 agctaatgtc accactaact gctttactcg ctgcttgcaa aacaaattca aaaagttagc 29280 attataatta gaataggatt taaacccccc ggtcatttcc tgctcaatac cattcccctg 29340 aacaattgac tctatgtggg atatgctcca gcgctacaac cttgaagtca ggcttcctgg 29400 atgtcagcat ctgactttgg ccagcacctg tcccgcggat ttgttccagt ccaactacag 29460 cgacccaccc taacagagat gaccaacaca accaacgcgg ccgccgctac cggacttaca 29520 tctaccacaa atacacccca agtttctgcc tttgtcaata actgggataa cttgggcatg 29580 tggtggttct ccatagcgct tatgtttgta tgccttatta ttatgtggct catctgctgc 29640 ctaaagcgca aacgcgcccg accacccatc tatagtccca tcattgtgct acacccaaac 29700 aatgatggaa tccatagatt ggacggactg aaacacatgt tcttttctct tacagtatga 29760 ttaaatgaga catgattcct cgagttttta tattactgac ccttgttgcg cttttttgtg 29820 cgtgctccac attggctgcg gtttctcaca tcgaagtaga ctgcattcca gccttcacag 29880 tctatttgct ttacggattt gtcaccctca cgctcatctg cagcctcatc actgtggtca 29940 tcgcctttat ccagtgcatt gactgggtct gtgtgcgctt tgcatatctc agacaccatc 30000 cccagtacag ggacaggact atagctgagc ttcttagaat tctttaatta tgaaatttac 30060 tgtgactttt ctgctgatta tttgcaccct atctgcgttt tgttccccga cctccaagcc 30120 tcaaagacat atatcatgca gattcactcg tatatggaat attccaagtt gctacaatga 30180 aaaaagcgat ctttccgaag cctggttata tgcaatcatc tctgttatgg tgttctgcag 30240 taccatctta gccctagcta tatatcccta ccttgacatt ggctggaacg caatagatgc 30300 catgaaccac ccaactttcc ccgcgcccgc tatgcttcca ctgcaacaag ttgttgccgg 30360 cggctttgtc ccagccaatc agcctcgccc accttctccc acccccactg aaatcagcta 30420 ctttaatcta acaggaggag atgactgaca ccctagatct agaaatggac ggaattatta 30480 cagagcagcg cctgctagaa agacgcaggg cagcggccga gcaacagcgc atgaatcaag 30540 agctccaaga catggttaac ttgcaccagt gcaaaagggg tatcttttgt ctggtaaagc 30600 aggccaaagt cacctacgac agtaatacca ccggacaccg ccttagctac aagttgccaa 30660 ccaagcgtca gaaattggtg gtcatggtgg gagaaaagcc cattaccata actcagcact 30720 cggtagaaac cgaaggctgc attcactcac cttgtcaagg acctgaggat ctctgcaccc 30780 ttattaagac cctgtgcggt ctcaaagatc ttattccctt taactaataa aaaaaaataa 30840 taaagcatca cttacttaaa atcagttagc aaatttctgt ccagtttatt cagcagcacc 30900 tccttgccct cctcccagct ctggtattgc agcttcctcc tggctgcaaa ctttctccac 30960 aatctaaatg gaatgtcagt ttcctcctgt tcctgtccat ccgcacccac tatcttcatg 31020 ttgttgcaga tgaagcgcgc aagaccgtct gaagatacct tcaaccccgt gtatccatat 31080 gacacggaaa ccggtcctcc aactgtgcct tttcttactc ctccctttgt atcccccaat 31140 gggtttcaag agagtccccc tggggtactc tctttgcgcc tatccgaacc tctagttacc 31200 tccaatggca tgcttgcgct caaaatgggc aacggcctct ctctggacga ggccggcaac 31260 cttacctccc aaaatgtaac cactgtgagc ccacctctca aaaaaaccaa gtcaaacata 31320 aacctggaaa tatctgcacc cctcacagtt acctcagaag ccctaactgt ggctgccgcc 31380 gcacctctaa tggtcgcggg caacacactc accatgcaat cacaggcccc gctaaccgtg 31440 cacgactcca aacttagcat tgccacccaa ggacccctca cagtgtcaga aggaaagcta 31500 gccctgcaaa catcaggccc cctcaccacc accgatagca gtacccttac tatcactgcc 31560 tcaccccctc taactactgc cactggtagc ttgggcattg acttgaaaga gcccatttat 31620 acacaaaatg gaaaactagg actaaagtac ggggctcctt tgcatgtaac agacgaccta 31680 aacactttga ccgtagcaac tggtccaggt gtgactatta ataatacttc cttgcaaact 31740 aaagttactg gagccttggg ttttgattca caaggcaata tgcaacttaa tgtagcagga 31800 ggactaagga ttgattctca aaacagacgc cttatacttg atgttagtta tccgtttgat 31860 gctcaaaacc aactaaatct aagactagga cagggccctc tttttataaa ctcagcccac 31920 aacttggata ttaactacaa caaaggcctt tacttgttta cagcttcaaa caattccaaa 31980 aagcttgagg ttaacctaag cactgccaag gggttgatgt ttgacgctac agccatagcc 32040 attaatgcag gagatgggct tgaatttggt tcacctaatg caccaaacac aaatcccctc 32100 aaaacaaaaa ttggccatgg cctagaattt gattcaaaca aggctatggt tcctaaacta 32160 ggaactggcc ttagttttga cagcacaggt gccattacag taggaaacaa aaataatgat 32220 aagctaactt tgtggaccac accagctcca tctcctaact gtagactaaa tgcagagaaa 32280 gatgctaaac tcactttggt cttaacaaaa tgtggcagtc aaatacttgc tacagtttca 32340 gttttggctg ttaaaggcag tttggctcca atatctggaa cagttcaaag tgctcatctt 32400 attataagat ttgacgaaaa tggagtgcta ctaaacaatt ccttcctgga cccagaatat 32460 tggaacttta gaaatggaga tcttactgaa ggcacagcct atacaaacgc tgttggattt 32520 atgcctaacc tatcagctta tccaaaatct cacggtaaaa ctgccaaaag taacattgtc 32580 agtcaagttt acttaaacgg agacaaaact aaacctgtaa cactaaccat tacactaaac 32640 ggtacacagg aaacaggaga cacaactcca agtgcatact ctatgtcatt ttcatgggac 32700 tggtctggcc acaactacat taatgaaata tttgccacat cctcttacac tttttcatac 32760 attgcccaag aataaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca 32820 gaaaatttca agtcattttt cattcagtag tatagcccca ccaccacata gcttatacag 32880 atcaccgtac cttaatcaaa ctcacagaac cctagtattc aacctgccac ctccctccca 32940 acacacagag tacacagtcc tttctccccg gctggcctta aaaagcatca tatcatgggt 33000 aacagacata ttcttaggtg ttatattcca cacggtttcc tgtcgagcca aacgctcatc 33060 agtgatatta ataaactccc cgggcagctc acttaagttc atgtcgctgt ccagctgctg 33120 agccacaggc tgctgtccaa cttgcggttg cttaacgggc ggcgaaggag aagtccacgc 33180 ctacatgggg gtagagtcat aatcgtgcat caggataggg cggtggtgct gcagcagcgc 33240 gcgaataaac tgctgccgcc gccgctccgt cctgcaggaa tacaacatgg cagtggtctc 33300 ctcagcgatg attcgcaccg cccgcagcat aaggcgcctt gtcctccggg cacagcagcg 33360 caccctgatc tcacttaaat cagcacagta actgcagcac agcaccacaa tattgttcaa 33420 aatcccacag tgcaaggcgc tgtatccaaa gctcatggcg gggaccacag aacccacgtg 33480 gccatcatac cacaagcgca ggtagattaa gtggcgaccc ctcataaaca cgctggacat 33540 aaacattacc tcttttggca tgttgtaatt caccacctcc cggtaccata taaacctctg 33600 attaaacatg gcgccatcca ccaccatcct aaaccagctg gccaaaacct gcccgccggc 33660 tatacactgc agggaaccgg gactggaaca atgacagtgg agagcccagg actcgtaacc 33720 atggatcatc atgctcgtca tgatatcaat gttggcacaa cacaggcaca cgtgcataca 33780 cttcctcagg attacaagct cctcccgcgt tagaaccata tcccagggaa caacccattc 33840 ctgaatcagc gtaaatccca cactgcaggg aagacctcgc acgtaactca cgttgtgcat 33900 tgtcaaagtg ttacattcgg gcagcagcgg atgatcctcc agtatggtag cgcgggtttc 33960 tgtctcaaaa ggaggtagac gatccctact gtacggagtg cgccgagaca accgagatcg 34020 tgttggtcgt agtgtcatgc caaatggaac gccggacgta gtcatatttc ctgaagcaaa 34080 accaggtgcg ggcgtgacaa acagatctgc gtctccggtc tcgccgctta gatcgctctg 34140 tgtagtagtt gtagtatatc cactctctca aagcatccag gcgccccctg gcttcgggtt 34200 ctatgtaaac tccttcatgc gccgctgccc tgataacatc caccaccgca gaataagcca 34260 cacccagcca acctacacat tcgttctgcg agtcacacac gggaggagcg ggaagagctg 34320 gaagaaccat gttttttttt ttattccaaa agattatcca aaacctcaaa atgaagatct 34380 attaagtgaa cgcgctcccc tccggtggcg tggtcaaact ctacagccaa agaacagata 34440 atggcatttg taagatgttg cacaatggct tccaaaaggc aaacggccct cacgtccaag 34500 tggacgtaaa ggctaaaccc ttcagggtga atctcctcta taaacattcc agcaccttca 34560 accatgccca aataattctc atctcgccac cttctcaata tatctctaag caaatcccga 34620 atattaagtc cggccattgt aaaaatctgc tccagagcgc cctccacctt cagcctcaag 34680 cagcgaatca tgattgcaaa aattcaggtt cctcacagac ctgtataaga ttcaaaagcg 34740 gaacattaac aaaaataccg cgatcccgta ggtcccttcg cagggccagc tgaacataat 34800 cgtgcaggtc tgcacggacc agcgcggcca cttccccgcc aggaaccatg acaaaagaac 34860 ccacactgat tatgacacgc atactcggag ctatgctaac cagcgtagcc ccgatgtaag 34920 cttgttgcat gggcggcgat ataaaatgca aggtgctgct caaaaaatca ggcaaagcct 34980 cgcgcaaaaa agaaagcaca tcgtagtcat gctcatgcag ataaaggcag gtaagctccg 35040 gaaccaccac agaaaaagac accatttttc tctcaaacat gtctgcgggt ttctgcataa 35100 acacaaaata aaataacaaa aaaacattta aacattagaa gcctgtctta caacaggaaa 35160 aacaaccctt ataagcataa gacggactac ggccatgccg gcgtgaccgt aaaaaaactg 35220 gtcaccgtga ttaaaaagca ccaccgacag ctcctcggtc atgtccggag tcataatgta 35280 agactcggta aacacatcag gttgattcac atcggtcagt gctaaaaagc gaccgaaata 35340 gcccggggga atacataccc gcaggcgtag agacaacatt acagccccca taggaggtat 35400 aacaaaatta ataggagaga aaaacacata aacacctgaa aaaccctcct gcctaggcaa 35460 aatagcaccc tcccgctcca gaacaacata cagcgcttcc acagcggcag ccataacagt 35520 cagccttacc agtaaaaaag aaaacctatt aaaaaaacac cactcgacac ggcaccagct 35580 caatcagtca cagtgtaaaa aagggccaag tgcagagcga gtatatatag gactaaaaaa 35640 tgacgtaacg gttaaagtcc acaaaaaaca cccagaaaac cgcacgcgaa cctacgccca 35700 gaaacgaaag ccaaaaaacc cacaacttcc tcaaatcgtc acttccgttt tcccacgtta 35760 cgtcacttcc cattttaaga aaactacaat tcccaacaca tacaagttac tccgccctaa 35820 aacctacgtc acccgccccg ttcccacgcc ccgcgccacg tcacaaactc caccccctca 35880 ttatcatatt ggcttcaatc caaaataagg tatattattg atgatg 35926 <210> 6 <211> 35647 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO181) <400> 6 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagca taagtgtctt gctgtcttta 4080 tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct 4140 gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag 4200 cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta 4260 gatgatccag tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa 4320 gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg 4380 gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc 4440 agccatatcc ctccggggat tcatgttgtg cagaaccacc agcacagtgt atccggtgca 4500 cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt 4560 gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc 4620 ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc 4680 gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcggta taatggttcc 4740 atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga 4800 tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg taggggagat 4860 cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta 4920 aatcacacct attaccgggt gcaactggta gttaagagag ctgcagctgc cgtcatccct 4980 gagcaggggg gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc 5040 cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa 5100 cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg 5160 gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc 5220 gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc 5280 atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc 5340 gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc 5400 tgccggtctt cgccctgcgc gtcggccagg tagcatttga ccatggtgtc atagtccagc 5460 ccctccgcgg cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg 5520 cagtgcagac ttttgagggc gtagagcttg ggcgcgagaa ataccgattc cggggagtag 5580 gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc 5640 cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt 5700 tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac 5760 ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac 5820 tctgagacaa aggctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg 5880 tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg 5940 gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg 6000 gggctataaa agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg 6060 agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga 6120 ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg 6180 agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca 6240 aacgacccgt agagggcgtt ggacagcaac ttggcgatgg agcgcagggt ttggtttttg 6300 tcgcgatcgg cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac 6360 cgccattcgg gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg 6420 ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc 6480 cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg 6540 tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct 6600 atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg 6660 tatgggttga gtgggggacc ccatggcatg gggtgggtga gcgcggaggc gtacatgccg 6720 caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt 6780 ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg 6840 ggaccgaggt tgctacgggc gggctgctct gctcggaaga ctatctgcct gaagatggca 6900 tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct 6960 accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg 7020 acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt 7080 cccttttttt tccacagctc gcggttgagg acaaactctt cgcggtcttt ccagtactct 7140 tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg 7200 gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg 7260 agcgaggtgt gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg 7320 aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa 7380 cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata 7440 aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg 7500 gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag ttccaagaag 7560 cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg 7620 gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat 7680 gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg 7740 cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag 7800 cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg 7860 ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta 7920 taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg 7980 aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag 8040 tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag 8100 cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag 8160 agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct 8220 tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc 8280 gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga 8340 tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg 8400 tttacctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg 8460 ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg 8520 gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt 8580 gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg 8640 gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg 8700 cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg 8760 tgagcttgag cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct 8820 ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact 8880 gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt 8940 cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc 9000 ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga 9060 gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg 9120 tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt 9180 tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga 9240 aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg 9300 cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct 9360 cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac 9420 ggcggcgacg acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc 9480 gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc 9540 cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc 9600 taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt 9660 ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 9720 gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg 9780 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca 9840 ccatgtcctt gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt 9900 tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt 9960 cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg 10020 gccgtaggtg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa 10080 gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg 10140 tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag 10200 tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt 10260 acctgagacg cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt 10320 actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg 10380 ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg 10440 acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc 10500 agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg gtcaggcgcg 10560 cgcaatcgtt gacgctctag accgtgcaaa aggagagcct gtaagcgggc actcttccgt 10620 ggtctggtgg ataaattcgc aagggtatca tggcggacga ccggggttcg agccccgtat 10680 ccggccgtcc gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg 10740 tcagacaacg ggggagtgct ccttttggct tccttccagg cgcggcggct gctgcgctag 10800 cttttttggc cactggccgc gcgcagcgta agcggttagg ctggaaagcg aaagcattaa 10860 gtggctcgct ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg ggacccccgg 10920 ttcgagtctc ggaccggccg gactgcggcg aacgggggtt tgcctccccg tcatgcaaga 10980 ccccgcttgc aaattcctcc ggaaacaggg acgagcccct tttttgcttt tcccagatgc 11040 atccggtgct gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc 11100 agacatgcag ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca tccgcggttg 11160 acgcggcagc agatggtgat tacgaacccc cgcggcgccg ggcccggcac tacctggact 11220 tggaggaggg cgagggcctg gcgcggctag gagcgccctc tcctgagcgg tacccaaggg 11280 tgcagctgaa gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc 11340 gcgagggaga ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc 11400 ggcatggcct gaatcgcgag cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa 11460 ccgggattag tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc gcatacgagc 11520 agacggtgaa ccaggagatt aactttcaaa aaagctttaa caaccacgtg cgtacgcttg 11580 tggcgcgcga ggaggtggct ataggactga tgcatctgtg ggactttgta agcgcgctgg 11640 agcaaaaccc aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg cagcacagca 11700 gggacaacga ggcattcagg gatgcgctgc taaacatagt agagcccgag ggccgctggc 11760 tgctcgattt gataaacatc ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg 11820 ctgacaaggt ggccgccatc aactattcca tgcttagcct gggcaagttt tacgcccgca 11880 agatatacca taccccttac gttcccatag acaaggaggt aaagatcgag gggttctaca 11940 tgcgcatggc gctgaaggtg cttaccttga gcgacgacct gggcgtttat cgcaacgagc 12000 gcatccacaa ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc 12060 acagcctgca aagggccctg gctggcacgg gcagcggcga tagagaggcc gagtcctact 12120 ttgacgcggg cgctgacctg cgctgggccc caagccgacg cgccctggag gcagctgggg 12180 ccggacctgg gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat 12240 atgacgagga cgatgagtac gagccagagg acggcgagta ctaagcggtg atgtttctga 12300 tcagatgatg caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc 12360 cggccttaac tccacggacg actggcgcca ggtcatggac cgcatcatgt cgctgactgc 12420 gcgcaatcct gacgcgttcc ggcagcagcc gcaggccaac cggctctccg caattctgga 12480 agcggtggtc ccggcgcgcg caaaccccac gcacgagaag gtgctggcga tcgtaaacgc 12540 gctggccgaa aacagggcca tccggcccga cgaggccggc ctggtctacg acgcgctgct 12600 tcagcgcgtg gctcgttaca acagcggcaa cgtgcagacc aacctggacc ggctggtggg 12660 ggatgtgcgc gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca acctgggctc 12720 catggttgca ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc ggggacagga 12780 ggactacacc aactttgtga gcgcactgcg gctaatggtg actgagacac cgcaaagtga 12840 ggtgtaccag tctgggccag actatttttt ccagaccagt agacaaggcc tgcagaccgt 12900 aaacctgagc caggctttca aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg 12960 cgaccgcgcg accgtgtcta gcttgctgac gcccaactcg cgcctgttgc tgctgctaat 13020 agcgcccttc acggacagtg gcagcgtgtc ccgggacaca tacctaggtc acttgctgac 13080 actgtaccgc gaggccatag gtcaggcgca tgtggacgag catactttcc aggagattac 13140 aagtgtcagc cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa ccctaaacta 13200 cctgctgacc aaccggcggc agaagatccc ctcgttgcac agtttaaaca gcgaggagga 13260 gcgcattttg cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg acggggtaac 13320 gcccagcgtg gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa 13380 ccggccgttt atcaaccgcc taatggacta cttgcatcgc gcggccgccg tgaaccccga 13440 gtatttcacc aatgccatct tgaacccgca ctggctaccg ccccctggtt tctacaccgg 13500 gggattcgag gtgcccgagg gtaacgatgg attcctctgg gacgacatag acgacagcgt 13560 gttttccccg caaccgcaga ccctgctaga gttgcaacag cgcgagcagg cagaggcggc 13620 gctgcgaaag gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc 13680 gcggtcagat gctagtagcc catttccaag cttgataggg tctcttacca gcactcgcac 13740 cacccgcccg cgcctgctgg gcgaggagga gtacctaaac aactcgctgc tgcagccgca 13800 gcgcgaaaaa aacctgcctc cggcatttcc caacaacggg atagagagcc tagtggacaa 13860 gatgagtaga tggaagacgt acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc 13920 cacccgtcgt caaaggcacg accgtcagcg gggtctggtg tgggaggacg atgactcggc 13980 agacgacagc agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc accttcgccc 14040 caggctgggg agaatgtttt aaaaaaaaaa aagcatgatg caaaataaaa aactcaccaa 14100 ggccatggca ccgagcgttg gttttcttgt attcccctta gtatgcggcg cgcggcgatg 14160 tatgaggaag gtcctcctcc ctcctacgag agtgtggtga gcgcggcgcc agtggcggcg 14220 gcgctgggtt ctcccttcga tgctcccctg gacccgccgt ttgtgcctcc gcggtacctg 14280 cggcctaccg gggggagaaa cagcatccgt tactctgagt tggcacccct attcgacacc 14340 acccgtgtgt acctggtgga caacaagtca acggatgtgg catccctgaa ctaccagaac 14400 gaccacagca actttctgac cacggtcatt caaaacaatg actacagccc gggggaggca 14460 agcacacaga ccatcaatct tgacgaccgg tcgcactggg gcggcgacct gaaaaccatc 14520 ctgcatacca acatgccaaa tgtgaacgag ttcatgttta ccaataagtt taaggcgcgg 14580 gtgatggtgt cgcgcttgcc tactaaggac aatcaggtgg agctgaaata cgagtgggtg 14640 gagttcacgc tgcccgaggg caactactcc gagaccatga ccatagacct tatgaacaac 14700 gcgatcgtgg agcactactt gaaagtgggc agacagaacg gggttctgga aagcgacatc 14760 ggggtaaagt ttgacacccg caacttcaga ctggggtttg accccgtcac tggtcttgtc 14820 atgcctgggg tatatacaaa cgaagccttc catccagaca tcattttgct gccaggatgc 14880 ggggtggact tcacccacag ccgcctgagc aacttgttgg gcatccgcaa gcggcaaccc 14940 ttccaggagg gctttaggat cacctacgat gatctggagg gtggtaacat tcccgcactg 15000 ttggatgtgg acgcctacca ggcgagcttg aaagatgaca ccgaacaggg cgggggtggc 15060 gcaggcggca gcaacagcag tggcagcggc gcggaagaga actccaacgc ggcagccgcg 15120 gcaatgcagc cggtggagga catgaacgat catgccattc gcggcgacac ctttgccaca 15180 cgggctgagg agaagcgcgc tgaggccgaa gcagcggccg aagctgccgc ccccgctgcg 15240 caacccgagg tcgagaagcc tcagaagaaa ccggtgatca aacccctgac agaggacagc 15300 aagaaacgca gttacaacct aataagcaat gacagcacct tcacccagta ccgcagctgg 15360 taccttgcat acaactacgg cgaccctcag accggaatcc gctcatggac cctgctttgc 15420 actcctgacg taacctgcgg ctcggagcag gtctactggt cgttgccaga catgatgcaa 15480 gaccccgtga ccttccgctc cacgcgccag atcagcaact ttccggtggt gggcgccgag 15540 ctgttgcccg tgcactccaa gagcttctac aacgaccagg ccgtctactc ccaactcatc 15600 cgccagttta cctctctgac ccacgtgttc aatcgctttc ccgagaacca gattttggcg 15660 cgcccgccag cccccaccat caccaccgtc agtgaaaacg ttcctgctct cacagatcac 15720 gggacgctac cgctgcgcaa cagcatcgga ggagtccagc gagtgaccat tactgacgcc 15780 agacgccgca cctgccccta cgtttacaag gccctgggca tagtctcgcc gcgcgtccta 15840 tcgagccgca ctttttgagc aagcatgtcc atccttatat cgcccagcaa taacacaggc 15900 tggggcctgc gcttcccaag caagatgttt ggcggggcca agaagcgctc cgaccaacac 15960 ccagtgcgcg tgcgcgggca ctaccgcgcg ccctggggcg cgcacaaacg cggccgcact 16020 gggcgcacca ccgtcgatga cgccatcgac gcggtggtgg aggaggcgcg caactacacg 16080 cccacgccgc caccagtgtc cacagtggac gcggccattc agaccgtggt gcgcggagcc 16140 cggcgctatg ctaaaatgaa gagacggcgg aggcgcgtag cacgtcgcca ccgccgccga 16200 cccggcactg ccgcccaacg cgcggcggcg gccctgctta accgcgcacg tcgcaccggc 16260 cgacgggcgg ccatgcgggc cgctcgaagg ctggccgcgg gtattgtcac tgtgcccccc 16320 aggtccaggc gacgagcggc cgccgcagca gccgcggcca ttagtgctat gactcagggt 16380 cgcaggggca acgtgtattg ggtgcgcgac tcggttagcg gcctgcgcgt gcccgtgcgc 16440 acccgccccc cgcgcaacta gattgcaaga aaaaactact tagactcgta ctgttgtatg 16500 tatccagcgg cggcggcgcg caacgaagct atgtccaagc gcaaaatcaa agaagagatg 16560 ctccaggtca tcgcgccgga gatctatggc cccccgaaga aggaagagca ggattacaag 16620 ccccgaaagc taaagcgggt caaaaagaaa aagaaagatg atgatgatga acttgacgac 16680 gaggtggaac tgctgcacgc taccgcgccc aggcgacggg tacagtggaa aggtcgacgc 16740 gtaaaacgtg ttttgcgacc cggcaccacc gtagtcttta cgcccggtga gcgctccacc 16800 cgcacctaca agcgcgtgta tgatgaggtg tacggcgacg aggacctgct tgagcaggcc 16860 aacgagcgcc tcggggagtt tgcctacgga aagcggcata aggacatgct ggcgttgccg 16920 ctggacgagg gcaacccaac acctagccta aagcccgtaa cactgcagca ggtgctgccc 16980 gcgcttgcac cgtccgaaga aaagcgcggc ctaaagcgcg agtctggtga cttggcaccc 17040 accgtgcagc tgatggtacc caagcgccag cgactggaag atgtcttgga aaaaatgacc 17100 gtggaacctg ggctggagcc cgaggtccgc gtgcggccaa tcaagcaggt ggcgccggga 17160 ctgggcgtgc agaccgtgga cgttcagata cccactacca gtagcaccag tattgccacc 17220 gccacagagg gcatggagac acaaacgtcc ccggttgcct cagcggtggc ggatgccgcg 17280 gtgcaggcgg tcgctgcggc cgcgtccaag acctctacgg aggtgcaaac ggacccgtgg 17340 atgtttcgcg tttcagcccc ccggcgcccg cgcggttcga ggaagtacgg cgccgccagc 17400 gcgctactgc ccgaatatgc cctacatcct tccattgcgc ctacccccgg ctatcgtggc 17460 tacacctacc gccccagaag acgagcaact acccgacgcc gaaccaccac tggaacccgc 17520 cgccgccgtc gccgtcgcca gcccgtgctg gccccgattt ccgtgcgcag ggtggctcgc 17580 gaaggaggca ggaccctggt gctgccaaca gcgcgctacc accccagcat cgtttaaaag 17640 ccggtctttg tggttcttgc agatatggcc ctcacctgcc gcctccgttt cccggtgccg 17700 ggattccgag gaagaatgca ccgtaggagg ggcatggccg gccacggcct gacgggcggc 17760 atgcgtcgtg cgcaccaccg gcggcggcgc gcgtcgcacc gtcgcatgcg cggcggtatc 17820 ctgcccctcc ttattccact gatcgccgcg gcgattggcg ccgtgcccgg aattgcatcc 17880 gtggccttgc aggcgcagag acactgatta aaaacaagtt gcatgtggaa aaatcaaaat 17940 aaaaagtctg gactctcacg ctcgcttggt cctgtaacta ttttgtagaa tggaagacat 18000 caactttgcg tctctggccc cgcgacacgg ctcgcgcccg ttcatgggaa actggcaaga 18060 tatcggcacc agcaatatga gcggtggcgc cttcagctgg ggctcgctgt ggagcggcat 18120 taaaaatttc ggttccaccg ttaagaacta tggcagcaag gcctggaaca gcagcacagg 18180 ccagatgctg agggataagt tgaaagagca aaatttccaa caaaaggtgg tagatggcct 18240 ggcctctggc attagcgggg tggtggacct ggccaaccag gcagtgcaaa ataagattaa 18300 cagtaagctt gatccccgcc ctcccgtaga ggagcctcca ccggccgtgg agacagtgtc 18360 tccagagggg cgtggcgaaa agcgtccgcg ccccgacagg gaagaaactc tggtgacgca 18420 aatagacgag cctccctcgt acgaggaggc actaaagcaa ggcctgccca ccacccgtcc 18480 catcgcgccc atggctaccg gagtgctggg ccagcacaca cccgtaacgc tggacctgcc 18540 tccccccgcc gacacccagc agaaacctgt gctgccaggc ccgaccgccg ttgttgtaac 18600 ccgtcctagc cgcgcgtccc tgcgccgcgc cgccagcggt ccgcgatcgt tgcggcccgt 18660 agccagtggc aactggcaaa gcacactgaa cagcatcgtg ggtctggggg tgcaatccct 18720 gaagcgccga cgatgcttct gaatagctaa cgtgtcgtat gtgtgtcatg tatgcgtcca 18780 tgtcgccgcc agaggagctg ctgagccgcc gcgcgcccgc tttccaagat ggctacccct 18840 tcgatgatgc cgcagtggtc ttacatgcac atctcgggcc aggacgcctc ggagtacctg 18900 agccccgggc tggtgcagtt tgcccgcgcc accgagacgt acttcagcct gaataacaag 18960 tttagaaacc ccacggtggc gcctacgcac gacgtgacca cagaccggtc ccagcgtttg 19020 acgctgcggt tcatccctgt ggaccgtgag gatactgcgt actcgtacaa ggcgcggttc 19080 accctagctg tgggtgataa ccgtgtgctg gacatggctt ccacgtactt tgacatccgc 19140 ggcgtgctgg acaggggccc tacttttaag ccctactctg gcactgccta caacgccctg 19200 gctcccaagg gtgccccaaa tccttgcgaa tgggatgaag ctgctactgc tcttgaaata 19260 aacctagaag aagaggacga tgacaacgaa gacgaagtag acgagcaagc tgagcagcaa 19320 aaaactcacg tatttgggca ggcgccttat tctggtataa atattacaaa ggagggtatt 19380 caaataggtg tcgaaggtca aacacctaaa tatgccgata aaacatttca acctgaacct 19440 caaataggag aatctcagtg gtacgaaact gaaattaatc atgcagctgg gagagtcctt 19500 aaaaagacta ccccaatgaa accatgttac ggttcatatg caaaacccac aaatgaaaat 19560 ggagggcaag gcattcttgt aaagcaacaa aatggaaagc tagaaagtca agtggaaatg 19620 caatttttct caactactga ggcgaccgca ggcaatggtg ataacttgac tcctaaagtg 19680 gtattgtaca gtgaagatgt agatatagaa accccagaca ctcatatttc ttacatgccc 19740 actattaagg aaggtaactc acgagaacta atgggccaac aatctatgcc caacaggcct 19800 aattacattg cttttaggga caattttatt ggtctaatgt attacaacag cacgggtaat 19860 atgggtgttc tggcgggcca agcatcgcag ttgaatgctg ttgtagattt gcaagacaga 19920 aacacagagc tttcatacca gcttttgctt gattccattg gtgatagaac caggtacttt 19980 tctatgtgga atcaggctgt tgacagctat gatccagatg ttagaattat tgaaaatcat 20040 ggaactgaag atgaacttcc aaattactgc tttccactgg gaggtgtgat taatacagag 20100 actcttacca aggtaaaacc taaaacaggt caggaaaatg gatgggaaaa agatgctaca 20160 gaattttcag ataaaaatga aataagagtt ggaaataatt ttgccatgga aatcaatcta 20220 aatgccaacc tgtggagaaa tttcctgtac tccaacatag cgctgtattt gcccgacaag 20280 ctaaagtaca gtccttccaa cgtaaaaatt tctgataacc caaacaccta cgactacatg 20340 aacaagcgag tggtggctcc cgggttagtg gactgctaca ttaaccttgg agcacgctgg 20400 tcccttgact atatggacaa cgtcaaccca tttaaccacc accgcaatgc tggcctgcgc 20460 taccgctcaa tgttgctggg caatggtcgc tatgtgccct tccacatcca ggtgcctcag 20520 aagttctttg ccattaaaaa cctccttctc ctgccgggct catacaccta cgagtggaac 20580 ttcaggaagg atgttaacat ggttctgcag agctccctag gaaatgacct aagggttgac 20640 ggagccagca ttaagtttga tagcatttgc ctttacgcca ccttcttccc catggcccac 20700 aacaccgcct ccacgcttga ggccatgctt agaaacgaca ccaacgacca gtcctttaac 20760 gactatctct ccgccgccaa catgctctac cctatacccg ccaacgctac caacgtgccc 20820 atatccatcc cctcccgcaa ctgggcggct ttccgcggct gggccttcac gcgccttaag 20880 actaaggaaa ccccatcact gggctcgggc tacgaccctt attacaccta ctctggctct 20940 ataccctacc tagatggaac cttttacctc aaccacacct ttaagaaggt ggccattacc 21000 tttgactctt ctgtcagctg gcctggcaat gaccgcctgc ttacccccaa cgagtttgaa 21060 attaagcgct cagttgacgg ggagggttac aacgttgccc agtgtaacat gaccaaagac 21120 tggttcctgg tacaaatgct agctaactac aacattggct accagggctt ctatatccca 21180 gagagctaca aggaccgcat gtactccttc tttagaaact tccagcccat gagccgtcag 21240 gtggtggatg atactaaata caaggactac caacaggtgg gcatcctaca ccaacacaac 21300 aactctggat ttgttggcta ccttgccccc accatgcgcg aaggacaggc ctaccctgct 21360 aacttcccct atccgcttat aggcaagacc gcagttgaca gcattaccca gaaaaagttt 21420 ctttgcgatc gcaccctttg gcgcatccca ttctccagta actttatgtc catgggcgca 21480 ctcacagacc tgggccaaaa ccttctctac gccaactccg cccacgcgct agacatgact 21540 tttgaggtgg atcccatgga cgagcccacc cttctttatg ttttgtttga agtctttgac 21600 gtggtccgtg tgcaccggcc gcaccgcggc gtcatcgaaa ccgtgtacct gcgcacgccc 21660 ttctcggccg gcaacgccac aacataaaga agcaagcaac atcaacaaca gctgccgcca 21720 tgggctccag tgagcaggaa ctgaaagcca ttgtcaaaga tcttggttgt gggccatatt 21780 ttttgggcac ctatgacaag cgctttccag gctttgtttc tccacacaag ctcgcctgcg 21840 ccatagtcaa tacggccggt cgcgagactg ggggcgtaca ctggatggcc tttgcctgga 21900 acccgcactc aaaaacatgc tacctctttg agccctttgg cttttctgac cagcgactca 21960 agcaggttta ccagtttgag tacgagtcac tcctgcgccg tagcgccatt gcttcttccc 22020 ccgaccgctg tataacgctg gaaaagtcca cccaaagcgt acaggggccc aactcggccg 22080 cctgtggact attctgctgc atgtttctcc acgcctttgc caactggccc caaactccca 22140 tggatcacaa ccccaccatg aaccttatta ccggggtacc caactccatg ctcaacagtc 22200 cccaggtaca gcccaccctg cgtcgcaacc aggaacagct ctacagcttc ctggagcgcc 22260 actcgcccta cttccgcagc cacagtgcgc agattaggag cgccacttct ttttgtcact 22320 tgaaaaacat gtaaaaataa tgtactagag acactttcaa taaaggcaaa tgcttttatt 22380 tgtacactct cgggtgatta tttaccccca cccttgccgt ctgcgccgtt taaaaatcaa 22440 aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga tactggtgtt 22500 tagtgctcca cttaaactca ggcacaacca tccgcggcag ctcggtgaag ttttcactcc 22560 acaggctgcg caccatcacc aacgcgttta gcaggtcggg cgccgatatc ttgaagtcgc 22620 agttggggcc tccgccctgc gcgcgcgagt tgcgatacac agggttgcag cactggaaca 22680 ctatcagcgc cgggtggtgc acgctggcca gcacgctctt gtcggagatc agatccgcgt 22740 ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt tggtagctgc cttcccaaaa 22800 agggcgcgtg cccaggcttt gagttgcact cgcaccgtag tggcatcaaa aggtgaccgt 22860 gcccggtctg ggcgttagga tacagcgcct gcataaaagc cttgatctgc ttaaaagcca 22920 cctgagcctt tgcgccttca gagaagaaca tgccgcaaga cttgccggaa aactgattgg 22980 ccggacaggc cgcgtcgtgc acgcagcacc ttgcgtcggt gttggagatc tgcaccacat 23040 ttcggcccca ccggttcttc acgatcttgg ccttgctaga ctgctccttc agcgcgcgct 23100 gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc cttatttatc ataatgcttc 23160 cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg gtgcagccac aacgcgcagc 23220 ccgtgggctc gtgatgcttg taggtcacct ctgcaaacga ctgcaggtac gcctgcagga 23280 atcgccccat catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc aacccgcggt 23340 gctcctcgtt cagccaggtc ttgcatacgg ccgccagagc ttccacttgg tcaggcagta 23400 gtttgaagtt cgcctttaga tcgttatcca cgtggtactt gtccatcagc gcgcgcgcag 23460 cctccatgcc cttctcccac gcagacacga tcggcacact cagcgggttc atcaccgtaa 23520 tttcactttc cgcttcgctg ggctcttcct cttcctcttg cgtccgcata ccacgcgcca 23580 ctgggtcgtc ttcattcagc cgccgcactg tgcgcttacc tcctttgcca tgcttgatta 23640 gcaccggtgg gttgctgaaa cccaccattt gtagcgccac atcttctctt tcttcctcgc 23700 tgtccacgat tacctctggt gatggcgggc gctcgggctt gggagaaggg cgcttctttt 23760 tcttcttggg cgcaatggcc aaatccgccg ccgaggtcga tggccgcggg ctgggtgtgc 23820 gcggcaccag cgcgtcttgt gatgagtctt cctcgtcctc ggactcgata cgccgcctca 23880 tccgcttttt tgggggcgcc cggggaggcg gcggcgacgg ggacggggac gacacgtcct 23940 ccatggttgg gggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt tcgcgctgct 24000 cctcttcccg actggccatt tccttctcct ataggcagaa aaagatcatg gagtcagtcg 24060 agaagaagga cagcctaacc gccccctctg agttcgccac caccgcctcc accgatgccg 24120 ccaacgcgcc taccaccttc cccgtcgagg cacccccgct tgaggaggag gaagtgatta 24180 tcgagcagga cccaggtttt gtaagcgaag acgacgagga ccgctcagta ccaacagagg 24240 ataaaaagca agaccaggac aacgcagagg caaacgagga acaagtcggg cggggggacg 24300 aaaggcatgg cgactaccta gatgtgggag acgacgtgct gttgaagcat ctgcagcgcc 24360 agtgcgccat tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc gccatagcgg 24420 atgtcagcct tgcctacgaa cgccacctat tctcaccgcg cgtacccccc aaacgccaag 24480 aaaacggcac atgcgagccc aacccgcgcc tcaacttcta ccccgtattt gccgtgccag 24540 aggtgcttgc cacctatcac atctttttcc aaaactgcaa gataccccta tcctgccgtg 24600 ccaaccgcag ccgagcggac aagcagctgg ccttgcggca gggcgctgtc atacctgata 24660 tcgcctcgct caacgaagtg ccaaaaatct ttgagggtct tggacgcgac gagaagcgcg 24720 cggcaaacgc tctgcaacag gaaaacagcg aaaatgaaag tcactctgga gtgttggtgg 24780 aactcgaggg tgacaacgcg cgcctagccg tactaaaacg cagcatcgag gtcacccact 24840 ttgcctaccc ggcacttaac ctacccccca aggtcatgag cacagtcatg agtgagctga 24900 tcgtgcgccg tgcgcagccc ctggagaggg atgcaaattt gcaagaacaa acagaggagg 24960 gcctacccgc agttggcgac gagcagctag cgcgctggct tcaaacgcgc gagcctgccg 25020 acttggagga gcgacgcaaa ctaatgatgg ccgcagtgct cgttaccgtg gagcttgagt 25080 gcatgcagcg gttctttgct gacccggaga tgcagcgcaa gctagaggaa acattgcact 25140 acacctttcg acagggctac gtacgccagg cctgcaagat ctccaacgtg gagctctgca 25200 acctggtctc ctaccttgga attttgcacg aaaaccgcct tgggcaaaac gtgcttcatt 25260 ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac ttatttctat 25320 gctacacctg gcagacggcc atgggcgttt ggcagcagtg cttggaggag tgcaacctca 25380 aggagctgca gaaactgcta aagcaaaact tgaaggacct atggacggcc ttcaacgagc 25440 gctccgtggc cgcgcacctg gcggacatca ttttccccga acgcctgctt aaaaccctgc 25500 aacagggtct gccagacttc accagtcaaa gcatgttgca gaactttagg aactttatcc 25560 tagagcgctc aggaatcttg cccgccacct gctgtgcact tcctagcgac tttgtgccca 25620 ttaagtaccg cgaatgccct ccgccgcttt ggggccactg ctaccttctg cagctagcca 25680 actaccttgc ctaccactct gacataatgg aagacgtgag cggtgacggt ctactggagt 25740 gtcactgtcg ctgcaaccta tgcaccccgc accgctccct ggtttgcaat tcgcagctgc 25800 ttaacgaaag tcaaattatc ggtacctttg agctgcaggg tccctcgcct gacgaaaagt 25860 ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac gtcggcttac cttcgcaaat 25920 ttgtacctga ggactaccac gcccacgaga ttaggttcta cgaagaccaa tcccgcccgc 25980 caaatgcgga gcttaccgcc tgcgtcatta cccagggcca cattcttggc caattgcaag 26040 ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg acggggggtt tacttggacc 26100 cccagtccgg cgaggagctc aacccaatcc ccccgccgcc gcagccctat cagcagcagc 26160 cgcgggccct tgcttcccag gatggcaccc aaaaagaagc tgcagctgcc gccgccaccc 26220 acggacgagg aggaatactg ggacagtcag gcagaggagg ttttggacga ggaggaggag 26280 gacatgatgg aagactggga gagcctagac gaggaagctt ccgaggtcga agaggtgtca 26340 gacgaaacac cgtcaccctc ggtcgcattc ccctcgccgg cgccccagaa atcggcaacc 26400 ggttccagca tggctacaac ctccgctcct caggcgccgc cggcactgcc cgttcgccga 26460 cccaaccgta gatgggacac cactggaacc agggccggta agtccaagca gccgccgccg 26520 ttagcccaag agcaacaaca gcgccaaggc taccgctcat ggcgcgggca caagaacgcc 26580 atagttgctt gcttgcaaga ctgtgggggc aacatctcct tcgcccgccg ctttcttctc 26640 taccatcacg gcgtggcctt cccccgtaac atcctgcatt actaccgtca tctctacagc 26700 ccatactgca ccggcggcag cggcagcggc agcaacagca gcggccacac agaagcaaag 26760 gcgaccggat agcaagactc tgacaaagcc caagaaatcc acagcggcgg cagcagcagg 26820 aggaggagcg ctgcgtctgg cgcccaacga acccgtatcg acccgcgagc ttagaaacag 26880 gatttttccc actctgtatg ctatatttca acagagcagg ggccaagaac aagagctgaa 26940 aataaaaaac aggtctctgc gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga 27000 tcagcttcgg cgcacgctgg aagacgcgga ggctctcttc agtaaatact gcgcgctgac 27060 tcttaaggac tagtttcgcg ccctttctca aatttaagcg cgaaaactac gtcatctcca 27120 gcggccacac ccggcgccag cacctgtcgt cagcgccatt tatgagcaag gaaattccca 27180 cgccctacat gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact 27240 actcaacccg aataaactac atgagcgcgg gaccccacat gatatcccgg gtcaacggaa 27300 tacgcgccca ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta 27360 ataaccttaa tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca 27420 ccactgtggt acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc 27480 agcttgcggg cggctttcgt cacagggtgc ggtcgcccgg gcagggtata actcacctga 27540 caatcagagg gcgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc 27600 gtccggacgg gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg 27660 caatcctaac tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactctgc 27720 aatttattga ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc 27780 actatccgga tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg 27840 actgaatgtt aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc 27900 gccacaagtg ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc 27960 atatcgaggg cccggcgcac ggcgtccggc ttaccgccca gggagagctt gcccgtagcc 28020 tgattcggga gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc 28080 tcactgtgat ttgcaactgt cctaaccctg gattacatca agatctttgt tgccatctct 28140 gtgctgagta taataaatac agaaattaaa atatactggg gctcctatcg ccatcctgta 28200 aacgccaccg tcttcacccg cccaagcaaa ccaaggcgaa ccttacctgg tacttttaac 28260 atctctccct ctgtgattta caacagtttc aacccagacg gagtgagtct acgagagaac 28320 ctctccgagc tcagctactc catcagaaaa aacaccaccc tccttacctg ccgggaacgt 28380 acgagtgcgt caccggccgc tgcaccacac ctaccgcctg accgtaaacc agactttttc 28440 cggacagacc tcaataactc tgtttaccag aacaggaggt gagcttagaa aacccttagg 28500 gtattaggcc aaaggcgcag ctactgtggg gtttatgaac aattcaagca actctacggg 28560 ctattctaat tcaggtttct ctagaatcgg ggttggggtt attctctgtc ttgtgattct 28620 ctttattctt atactaacgc ttctctgcct aaggctcgcc gcctgctgtg tgcacatttg 28680 catttattgt cagcttttta aacgctgggg tcgccaccca agatgattag gtacataatc 28740 ctaggtttac tcacccttgc gtcagcccac ggtaccaccc aaaaggtgga ttttaaggag 28800 ccagcctgta atgttacatt cgcagctgaa gctaatgagt gcaccactct tataaaatgc 28860 accacagaac atgaaaagct gcttattcgc cacaaaaaca aaattggcaa gtatgctgtt 28920 tatgctattt ggcagccagg tgacactaca gagtataatg ttacagtttt ccagggtaaa 28980 agtcataaaa cttttatgta tacttttcca ttttatgaaa tgtgcgacat taccatgtac 29040 atgagcaaac agtataagtt gtggccccca caaaattgtg tggaaaacac tggcactttc 29100 tgctgcactg ctatgctaat tacagtgctc gctttggtct gtaccctact ctatattaaa 29160 tacaaaagca gacgcagctt tattgaggaa aagaaaatgc cttaatttac taagttacaa 29220 agctaatgtc accactaact gctttactcg ctgcttgcaa aacaaattca aaaagttagc 29280 attataatta gaataggatt taaacccccc ggtcatttcc tgctcaatac cattcccctg 29340 aacaattgac tctatgtggg atatgctcca gcgctacaac cttgaagtca ggcttcctgg 29400 atgtcagcat ctgactttgg ccagcacctg tcccgcggat ttgttccagt ccaactacag 29460 cgacccaccc taacagagat gaccaacaca accaacgcgg ccgccgctac cggacttaca 29520 tctaccacaa atacacccca agtttctgcc tttgtcaata actgggataa cttgggcatg 29580 tggtggttct ccatagcgct tatgtttgta tgccttatta ttatgtggct catctgctgc 29640 ctaaagcgca aacgcgcccg accacccatc tatagtccca tcattgtgct acacccaaac 29700 aatgatggaa tccatagatt ggacggactg aaacacatgt tcttttctct tacagtatga 29760 ttaaatgaga catgattcct cgagttttta tattactgac ccttgttgcg cttttttgtg 29820 cgtgctccac attggctgcg gtttctcaca tcgaagtaga ctgcattcca gccttcacag 29880 tctatttgct ttacggattt gtcaccctca cgctcatctg cagcctcatc actgtggtca 29940 tcgcctttat ccagtgcatt gactgggtct gtgtgcgctt tgcatatctc agacaccatc 30000 cccagtacag ggacaggact atagctgagc ttcttagaat tctttaatta tgaaatttac 30060 tgtgactttt ctgctgatta tttgcaccct atctgcgttt tgttccccga cctccaagcc 30120 tcaaagacat atatcatgca gattcactcg tatatggaat attccaagtt gctacaatga 30180 aaaaagcgat ctttccgaag cctggttata tgcaatcatc tctgttatgg tgttctgcag 30240 taccatctta gccctagcta tatatcccta ccttgacatt ggctggaacg caatagatgc 30300 catgaaccac ccaactttcc ccgcgcccgc tatgcttcca ctgcaacaag ttgttgccgg 30360 cggctttgtc ccagccaatc agcctcgccc accttctccc acccccactg aaatcagcta 30420 ctttaatcta acaggaggag atgactgaca ccctagatct agaaatggac ggaattatta 30480 cagagcagcg cctgctagaa agacgcaggg cagcggccga gcaacagcgc atgaatcaag 30540 agctccaaga catggttaac ttgcaccagt gcaaaagggg tatcttttgt ctggtaaagc 30600 aggccaaagt cacctacgac agtaatacca ccggacaccg ccttagctac aagttgccaa 30660 ccaagcgtca gaaattggtg gtcatggtgg gagaaaagcc cattaccata actcagcact 30720 cggtagaaac cgaaggctgc attcactcac cttgtcaagg acctgaggat ctctgcaccc 30780 ttattaagac cctgtgcggt ctcaaagatc ttattccctt taactaataa aaaaaaataa 30840 taaagcatca cttacttaaa atcagttagc aaatttctgt ccagtttatt cagcagcacc 30900 tccttgccct cctcccagct ctggtattgc agcttcctcc tggctgcaaa ctttctccac 30960 aatctaaatg gaatgtcagt ttcctcctgt tcctgtccat ccgcacccac tatcttcatg 31020 ttgttgcaga tgaagcgcgc aagaccgtct gaagatacct tcaaccccgt gtatccatat 31080 gacacggaaa ccggtcctcc aactgtgcct tttcttactc ctccctttgt atcccccaat 31140 gggtttcaag agagtccccc tggggtactc tctttgcgcc tatccgaacc tctagttacc 31200 tccaatggca tgcttgcgct caaaatgggc aacggcctct ctctggacga ggccggcaac 31260 cttacctccc aaaatgtaac cactgtgagc ccacctctca aaaaaaccaa gtcaaacata 31320 aacctggaaa tatctgcacc cctcacagtt acctcagaag ccctaactgt ggctgccgcc 31380 gcacctctaa tggtcgcggg caacacactc accatgcaat cacaggcccc gctaaccgtg 31440 cacgactcca aacttagcat tgccacccaa ggacccctca cagtgtcaga aggaaagcta 31500 gccctgcaaa catcaggccc cctcaccacc accgatagca gtacccttac tatcactgcc 31560 tcaccccctc taactactgc cactggtagc ttgggcattg acttgaaaga gcccatttat 31620 acacaaaatg gaaaactagg actaaagtac ggggctcctt tgcatgtaac agacgaccta 31680 aacactttga ccgtagcaac tggtccaggt gtgactatta ataatacttc cttgcaaact 31740 aaagttactg gagccttggg ttttgattca caaggcaata tgcaacttaa tgtagcagga 31800 ggactaagga ttgattctca aaacagacgc cttatacttg atgttagtta tccgtttgat 31860 gctcaaaacc aactaaatct aagactagga cagggccctc tttttataaa ctcagcccac 31920 aacttggata ttaactacaa caaaggcctt tacttgttta cagcttcaaa caattccaaa 31980 aagcttgagg ttaacctaag cactgccaag gggttgatgt ttgacgctac agccatagcc 32040 attaatgcag gagatgggct tgaatttggt tcacctaatg caccaaacac aaatcccctc 32100 aaaacaaaaa ttggccatgg cctagaattt gattcaaaca aggctatggt tcctaaacta 32160 ggaactggcc ttagttttga cagcacaggt gccattacag taggaaacaa aaataatgat 32220 aagctaactt tgtggaccac accagctcca tctcctaact gtagactaaa tgcagagaaa 32280 gatgctaaac tcactttggt cttaacaaaa tgtggcagtc aaatacttgc tacagtttca 32340 gttttggctg ttaaaggcag tttggctcca atatctggaa cagttcaaag tgctcatctt 32400 attataagat ttgacgaaaa tggagtgcta ctaaacaatt ccttcctgga cccagaatat 32460 tggaacttta gaaatggaga tcttactgaa ggcacagcct atacaaacgc tgttggattt 32520 atgcctaacc tatcagctta tccaaaatct cacggtaaaa ctgccaaaag taacattgtc 32580 agtcaagttt acttaaacgg agacaaaact aaacctgtaa cactaaccat tacactaaac 32640 ggtacacagg aaacaggaga cacaactcca agtgcatact ctatgtcatt ttcatgggac 32700 tggtctggcc acaactacat taatgaaata tttgccacat cctcttacac tttttcatac 32760 attgcccaag aataaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca 32820 gaaaatttca agtcattttt cattcagtag tatagcccca ccaccacata gcttatacag 32880 atcaccgtac cttaatcaaa cctacatggg ggtagagtca taatcgtgca tcaggatagg 32940 gcggtggtgc tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga 33000 atacaacatg gcagtggtct cctcagcgat gattcgcacc gcccgcagca taaggcgcct 33060 tgtcctccgg gcacagcagc gcaccctgat ctcacttaaa tcagcacagt aactgcagca 33120 cagcaccaca atattgttca aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc 33180 ggggaccaca gaacccacgt ggccatcata ccacaagcgc aggtagatta agtggcgacc 33240 cctcataaac acgctggaca taaacattac ctcttttggc atgttgtaat tcaccacctc 33300 ccggtaccat ataaacctct gattaaacat ggcgccatcc accaccatcc taaaccagct 33360 ggccaaaacc tgcccgccgg ctatacactg cagggaaccg ggactggaac aatgacagtg 33420 gagagcccag gactcgtaac catggatcat catgctcgtc atgatatcaa tgttggcaca 33480 acacaggcac acgtgcatac acttcctcag gattacaagc tcctcccgcg ttagaaccat 33540 atcccaggga acaacccatt cctgaatcag cgtaaatccc acactgcagg gaagacctcg 33600 cacgtaactc acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc 33660 cagtatggta gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac tgtacggagt 33720 gcgccgagac aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt 33780 agtcatattt cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg cgtctccggt 33840 ctcgccgctt agatcgctct gtgtagtagt tgtagtatat ccactctctc aaagcatcca 33900 ggcgccccct ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc ctgataacat 33960 ccaccaccgc agaataagcc acacccagcc aacctacaca ttcgttctgc gagtcacaca 34020 cgggaggagc gggaagagct ggaagaacca tgtttttttt tttattccaa aagattatcc 34080 aaaacctcaa aatgaagatc tattaagtga acgcgctccc ctccggtggc gtggtcaaac 34140 tctacagcca aagaacagat aatggcattt gtaagatgtt gcacaatggc ttccaaaagg 34200 caaacggccc tcacgtccaa gtggacgtaa aggctaaacc cttcagggtg aatctcctct 34260 ataaacattc cagcaccttc aaccatgccc aaataattct catctcgcca ccttctcaat 34320 atatctctaa gcaaatcccg aatattaagt ccggccattg taaaaatctg ctccagagcg 34380 ccctccacct tcagcctcaa gcagcgaatc atgattgcaa aaattcaggt tcctcacaga 34440 cctgtataag attcaaaagc ggaacattaa caaaaatacc gcgatcccgt aggtcccttc 34500 gcagggccag ctgaacataa tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc 34560 caggaaccat gacaaaagaa cccacactga ttatgacacg catactcgga gctatgctaa 34620 ccagcgtagc cccgatgtaa gcttgttgca tgggcggcga tataaaatgc aaggtgctgc 34680 tcaaaaaatc aggcaaagcc tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca 34740 gataaaggca ggtaagctcc ggaaccacca cagaaaaaga caccattttt ctctcaaaca 34800 tgtctgcggg tttctgcata aacacaaaat aaaataacaa aaaaacattt aaacattaga 34860 agcctgtctt acaacaggaa aaacaaccct tataagcata agacggacta cggccatgcc 34920 ggcgtgaccg taaaaaaact ggtcaccgtg attaaaaagc accaccgaca gctcctcggt 34980 catgtccgga gtcataatgt aagactcggt aaacacatca ggttgattca catcggtcag 35040 tgctaaaaag cgaccgaaat agcccggggg aatacatacc cgcaggcgta gagacaacat 35100 tacagccccc ataggaggta taacaaaatt aataggagag aaaaacacat aaacacctga 35160 aaaaccctcc tgcctaggca aaatagcacc ctcccgctcc agaacaacat acagcgcttc 35220 cacagcggca gccataacag tcagccttac cagtaaaaaa gaaaacctat taaaaaaaca 35280 ccactcgaca cggcaccagc tcaatcagtc acagtgtaaa aaagggccaa gtgcagagcg 35340 agtatatata ggactaaaaa atgacgtaac ggttaaagtc cacaaaaaac acccagaaaa 35400 ccgcacgcga acctacgccc agaaacgaaa gccaaaaaac ccacaacttc ctcaaatcgt 35460 cacttccgtt ttcccacgtt acgtcacttc ccattttaag aaaactacaa ttcccaacac 35520 atacaagtta ctccgcccta aaacctacgt cacccgcccc gttcccacgc cccgcgccac 35580 gtcacaaact ccaccccctc attatcatat tggcttcaat ccaaaataag gtatattatt 35640 gatgatg 35647 <210> 7 <211> 35638 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO285) <400> 7 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagca taagtgtctt gctgtcttta 4080 tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct 4140 gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag 4200 cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta 4260 gatgatccag tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa 4320 gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg 4380 gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc 4440 agccatatcc ctccggggat tcatgttgtg cagaaccacc agcacagtgt atccggtgca 4500 cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt 4560 gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc 4620 ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc 4680 gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcggta taatggttcc 4740 atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga 4800 tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg taggggagat 4860 cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta 4920 aatcacacct attaccgggt gcaactggta gttaagagag ctgcagctgc cgtcatccct 4980 gagcaggggg gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc 5040 cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa 5100 cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg 5160 gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc 5220 gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc 5280 atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc 5340 gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc 5400 tgccggtctt cgccctgcgc gtcggccagg tagcatttga ccatggtgtc atagtccagc 5460 ccctccgcgg cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg 5520 cagtgcagac ttttgagggc gtagagcttg ggcgcgagaa ataccgattc cggggagtag 5580 gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc 5640 cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt 5700 tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac 5760 ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac 5820 tctgagacaa aggctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg 5880 tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg 5940 gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg 6000 gggctataaa agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg 6060 agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga 6120 ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg 6180 agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca 6240 aacgacccgt agagggcgtt ggacagcaac ttggcgatgg agcgcagggt ttggtttttg 6300 tcgcgatcgg cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac 6360 cgccattcgg gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg 6420 ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc 6480 cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg 6540 tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct 6600 atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg 6660 tatgggttga gtgggggacc ccatggcatg gggtgggtga gcgcggaggc gtacatgccg 6720 caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt 6780 ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg 6840 ggaccgaggt tgctacgggc gggctgctct gctcggaaga ctatctgcct gaagatggca 6900 tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct 6960 accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg 7020 acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt 7080 cccttttttt tccacagctc gcggttgagg acaaactctt cgcggtcttt ccagtactct 7140 tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg 7200 gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg 7260 agcgaggtgt gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg 7320 aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa 7380 cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata 7440 aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg 7500 gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag ttccaagaag 7560 cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg 7620 gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat 7680 gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg 7740 cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag 7800 cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg 7860 ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta 7920 taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg 7980 aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag 8040 tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag 8100 cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag 8160 agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct 8220 tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc 8280 gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga 8340 tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg 8400 tttacctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg 8460 ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg 8520 gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt 8580 gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg 8640 gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg 8700 cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg 8760 tgagcttgag cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct 8820 ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact 8880 gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt 8940 cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc 9000 ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga 9060 gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg 9120 tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt 9180 tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga 9240 aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg 9300 cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct 9360 cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac 9420 ggcggcgacg acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc 9480 gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc 9540 cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc 9600 taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt 9660 ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 9720 gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg 9780 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca 9840 ccatgtcctt gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt 9900 tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt 9960 cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg 10020 gccgtaggtg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa 10080 gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg 10140 tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag 10200 tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt 10260 acctgagacg cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt 10320 actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg 10380 ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg 10440 acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc 10500 agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg gtcaggcgcg 10560 cgcaatcgtt gacgctctag accgtgcaaa aggagagcct gtaagcgggc actcttccgt 10620 ggtctggtgg ataaattcgc aagggtatca tggcggacga ccggggttcg agccccgtat 10680 ccggccgtcc gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg 10740 tcagacaacg ggggagtgct ccttttggct tccttccagg cgcggcggct gctgcgctag 10800 cttttttggc cactggccgc gcgcagcgta agcggttagg ctggaaagcg aaagcattaa 10860 gtggctcgct ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg ggacccccgg 10920 ttcgagtctc ggaccggccg gactgcggcg aacgggggtt tgcctccccg tcatgcaaga 10980 ccccgcttgc aaattcctcc ggaaacaggg acgagcccct tttttgcttt tcccagatgc 11040 atccggtgct gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc 11100 agacatgcag ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca tccgcggttg 11160 acgcggcagc agatggtgat tacgaacccc cgcggcgccg ggcccggcac tacctggact 11220 tggaggaggg cgagggcctg gcgcggctag gagcgccctc tcctgagcgg tacccaaggg 11280 tgcagctgaa gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc 11340 gcgagggaga ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc 11400 ggcatggcct gaatcgcgag cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa 11460 ccgggattag tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc gcatacgagc 11520 agacggtgaa ccaggagatt aactttcaaa aaagctttaa caaccacgtg cgtacgcttg 11580 tggcgcgcga ggaggtggct ataggactga tgcatctgtg ggactttgta agcgcgctgg 11640 agcaaaaccc aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg cagcacagca 11700 gggacaacga ggcattcagg gatgcgctgc taaacatagt agagcccgag ggccgctggc 11760 tgctcgattt gataaacatc ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg 11820 ctgacaaggt ggccgccatc aactattcca tgcttagcct gggcaagttt tacgcccgca 11880 agatatacca taccccttac gttcccatag acaaggaggt aaagatcgag gggttctaca 11940 tgcgcatggc gctgaaggtg cttaccttga gcgacgacct gggcgtttat cgcaacgagc 12000 gcatccacaa ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc 12060 acagcctgca aagggccctg gctggcacgg gcagcggcga tagagaggcc gagtcctact 12120 ttgacgcggg cgctgacctg cgctgggccc caagccgacg cgccctggag gcagctgggg 12180 ccggacctgg gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat 12240 atgacgagga cgatgagtac gagccagagg acggcgagta ctaagcggtg atgtttctga 12300 tcagatgatg caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc 12360 cggccttaac tccacggacg actggcgcca ggtcatggac cgcatcatgt cgctgactgc 12420 gcgcaatcct gacgcgttcc ggcagcagcc gcaggccaac cggctctccg caattctgga 12480 agcggtggtc ccggcgcgcg caaaccccac gcacgagaag gtgctggcga tcgtaaacgc 12540 gctggccgaa aacagggcca tccggcccga cgaggccggc ctggtctacg acgcgctgct 12600 tcagcgcgtg gctcgttaca acagcggcaa cgtgcagacc aacctggacc ggctggtggg 12660 ggatgtgcgc gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca acctgggctc 12720 catggttgca ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc ggggacagga 12780 ggactacacc aactttgtga gcgcactgcg gctaatggtg actgagacac cgcaaagtga 12840 ggtgtaccag tctgggccag actatttttt ccagaccagt agacaaggcc tgcagaccgt 12900 aaacctgagc caggctttca aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg 12960 cgaccgcgcg accgtgtcta gcttgctgac gcccaactcg cgcctgttgc tgctgctaat 13020 agcgcccttc acggacagtg gcagcgtgtc ccgggacaca tacctaggtc acttgctgac 13080 actgtaccgc gaggccatag gtcaggcgca tgtggacgag catactttcc aggagattac 13140 aagtgtcagc cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa ccctaaacta 13200 cctgctgacc aaccggcggc agaagatccc ctcgttgcac agtttaaaca gcgaggagga 13260 gcgcattttg cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg acggggtaac 13320 gcccagcgtg gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa 13380 ccggccgttt atcaaccgcc taatggacta cttgcatcgc gcggccgccg tgaaccccga 13440 gtatttcacc aatgccatct tgaacccgca ctggctaccg ccccctggtt tctacaccgg 13500 gggattcgag gtgcccgagg gtaacgatgg attcctctgg gacgacatag acgacagcgt 13560 gttttccccg caaccgcaga ccctgctaga gttgcaacag cgcgagcagg cagaggcggc 13620 gctgcgaaag gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc 13680 gcggtcagat gctagtagcc catttccaag cttgataggg tctcttacca gcactcgcac 13740 cacccgcccg cgcctgctgg gcgaggagga gtacctaaac aactcgctgc tgcagccgca 13800 gcgcgaaaaa aacctgcctc cggcatttcc caacaacggg atagagagcc tagtggacaa 13860 gatgagtaga tggaagacgt acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc 13920 cacccgtcgt caaaggcacg accgtcagcg gggtctggtg tgggaggacg atgactcggc 13980 agacgacagc agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc accttcgccc 14040 caggctgggg agaatgtttt aaaaaaaaaa aagcatgatg caaaataaaa aactcaccaa 14100 ggccatggca ccgagcgttg gttttcttgt attcccctta gtatgcggcg cgcggcgatg 14160 tatgaggaag gtcctcctcc ctcctacgag agtgtggtga gcgcggcgcc agtggcggcg 14220 gcgctgggtt ctcccttcga tgctcccctg gacccgccgt ttgtgcctcc gcggtacctg 14280 cggcctaccg gggggagaaa cagcatccgt tactctgagt tggcacccct attcgacacc 14340 acccgtgtgt acctggtgga caacaagtca acggatgtgg catccctgaa ctaccagaac 14400 gaccacagca actttctgac cacggtcatt caaaacaatg actacagccc gggggaggca 14460 agcacacaga ccatcaatct tgacgaccgg tcgcactggg gcggcgacct gaaaaccatc 14520 ctgcatacca acatgccaaa tgtgaacgag ttcatgttta ccaataagtt taaggcgcgg 14580 gtgatggtgt cgcgcttgcc tactaaggac aatcaggtgg agctgaaata cgagtgggtg 14640 gagttcacgc tgcccgaggg caactactcc gagaccatga ccatagacct tatgaacaac 14700 gcgatcgtgg agcactactt gaaagtgggc agacagaacg gggttctgga aagcgacatc 14760 ggggtaaagt ttgacacccg caacttcaga ctggggtttg accccgtcac tggtcttgtc 14820 atgcctgggg tatatacaaa cgaagccttc catccagaca tcattttgct gccaggatgc 14880 ggggtggact tcacccacag ccgcctgagc aacttgttgg gcatccgcaa gcggcaaccc 14940 ttccaggagg gctttaggat cacctacgat gatctggagg gtggtaacat tcccgcactg 15000 ttggatgtgg acgcctacca ggcgagcttg aaagatgaca ccgaacaggg cgggggtggc 15060 gcaggcggca gcaacagcag tggcagcggc gcggaagaga actccaacgc ggcagccgcg 15120 gcaatgcagc cggtggagga catgaacgat catgccattc gcggcgacac ctttgccaca 15180 cgggctgagg agaagcgcgc tgaggccgaa gcagcggccg aagctgccgc ccccgctgcg 15240 caacccgagg tcgagaagcc tcagaagaaa ccggtgatca aacccctgac agaggacagc 15300 aagaaacgca gttacaacct aataagcaat gacagcacct tcacccagta ccgcagctgg 15360 taccttgcat acaactacgg cgaccctcag accggaatcc gctcatggac cctgctttgc 15420 actcctgacg taacctgcgg ctcggagcag gtctactggt cgttgccaga catgatgcaa 15480 gaccccgtga ccttccgctc cacgcgccag atcagcaact ttccggtggt gggcgccgag 15540 ctgttgcccg tgcactccaa gagcttctac aacgaccagg ccgtctactc ccaactcatc 15600 cgccagttta cctctctgac ccacgtgttc aatcgctttc ccgagaacca gattttggcg 15660 cgcccgccag cccccaccat caccaccgtc agtgaaaacg ttcctgctct cacagatcac 15720 gggacgctac cgctgcgcaa cagcatcgga ggagtccagc gagtgaccat tactgacgcc 15780 agacgccgca cctgccccta cgtttacaag gccctgggca tagtctcgcc gcgcgtccta 15840 tcgagccgca ctttttgagc aagcatgtcc atccttatat cgcccagcaa taacacaggc 15900 tggggcctgc gcttcccaag caagatgttt ggcggggcca agaagcgctc cgaccaacac 15960 ccagtgcgcg tgcgcgggca ctaccgcgcg ccctggggcg cgcacaaacg cggccgcact 16020 gggcgcacca ccgtcgatga cgccatcgac gcggtggtgg aggaggcgcg caactacacg 16080 cccacgccgc caccagtgtc cacagtggac gcggccattc agaccgtggt gcgcggagcc 16140 cggcgctatg ctaaaatgaa gagacggcgg aggcgcgtag cacgtcgcca ccgccgccga 16200 cccggcactg ccgcccaacg cgcggcggcg gccctgctta accgcgcacg tcgcaccggc 16260 cgacgggcgg ccatgcgggc cgctcgaagg ctggccgcgg gtattgtcac tgtgcccccc 16320 aggtccaggc gacgagcggc cgccgcagca gccgcggcca ttagtgctat gactcagggt 16380 cgcaggggca acgtgtattg ggtgcgcgac tcggttagcg gcctgcgcgt gcccgtgcgc 16440 acccgccccc cgcgcaacta gattgcaaga aaaaactact tagactcgta ctgttgtatg 16500 tatccagcgg cggcggcgcg caacgaagct atgtccaagc gcaaaatcaa agaagagatg 16560 ctccaggtca tcgcgccgga gatctatggc cccccgaaga aggaagagca ggattacaag 16620 ccccgaaagc taaagcgggt caaaaagaaa aagaaagatg atgatgatga acttgacgac 16680 gaggtggaac tgctgcacgc taccgcgccc aggcgacggg tacagtggaa aggtcgacgc 16740 gtaaaacgtg ttttgcgacc cggcaccacc gtagtcttta cgcccggtga gcgctccacc 16800 cgcacctaca agcgcgtgta tgatgaggtg tacggcgacg aggacctgct tgagcaggcc 16860 aacgagcgcc tcggggagtt tgcctacgga aagcggcata aggacatgct ggcgttgccg 16920 ctggacgagg gcaacccaac acctagccta aagcccgtaa cactgcagca ggtgctgccc 16980 gcgcttgcac cgtccgaaga aaagcgcggc ctaaagcgcg agtctggtga cttggcaccc 17040 accgtgcagc tgatggtacc caagcgccag cgactggaag atgtcttgga aaaaatgacc 17100 gtggaacctg ggctggagcc cgaggtccgc gtgcggccaa tcaagcaggt ggcgccggga 17160 ctgggcgtgc agaccgtgga cgttcagata cccactacca gtagcaccag tattgccacc 17220 gccacagagg gcatggagac acaaacgtcc ccggttgcct cagcggtggc ggatgccgcg 17280 gtgcaggcgg tcgctgcggc cgcgtccaag acctctacgg aggtgcaaac ggacccgtgg 17340 atgtttcgcg tttcagcccc ccggcgcccg cgcggttcga ggaagtacgg cgccgccagc 17400 gcgctactgc ccgaatatgc cctacatcct tccattgcgc ctacccccgg ctatcgtggc 17460 tacacctacc gccccagaag acgagcaact acccgacgcc gaaccaccac tggaacccgc 17520 cgccgccgtc gccgtcgcca gcccgtgctg gccccgattt ccgtgcgcag ggtggctcgc 17580 gaaggaggca ggaccctggt gctgccaaca gcgcgctacc accccagcat cgtttaaaag 17640 ccggtctttg tggttcttgc agatatggcc ctcacctgcc gcctccgttt cccggtgccg 17700 ggattccgag gaagaatgca ccgtaggagg ggcatggccg gccacggcct gacgggcggc 17760 atgcgtcgtg cgcaccaccg gcggcggcgc gcgtcgcacc gtcgcatgcg cggcggtatc 17820 ctgcccctcc ttattccact gatcgccgcg gcgattggcg ccgtgcccgg aattgcatcc 17880 gtggccttgc aggcgcagag acactgatta aaaacaagtt gcatgtggaa aaatcaaaat 17940 aaaaagtctg gactctcacg ctcgcttggt cctgtaacta ttttgtagaa tggaagacat 18000 caactttgcg tctctggccc cgcgacacgg ctcgcgcccg ttcatgggaa actggcaaga 18060 tatcggcacc agcaatatga gcggtggcgc cttcagctgg ggctcgctgt ggagcggcat 18120 taaaaatttc ggttccaccg ttaagaacta tggcagcaag gcctggaaca gcagcacagg 18180 ccagatgctg agggataagt tgaaagagca aaatttccaa caaaaggtgg tagatggcct 18240 ggcctctggc attagcgggg tggtggacct ggccaaccag gcagtgcaaa ataagattaa 18300 cagtaagctt gatccccgcc ctcccgtaga ggagcctcca ccggccgtgg agacagtgtc 18360 tccagagggg cgtggcgaaa agcgtccgcg ccccgacagg gaagaaactc tggtgacgca 18420 aatagacgag cctccctcgt acgaggaggc actaaagcaa ggcctgccca ccacccgtcc 18480 catcgcgccc atggctaccg gagtgctggg ccagcacaca cccgtaacgc tggacctgcc 18540 tccccccgcc gacacccagc agaaacctgt gctgccaggc ccgaccgccg ttgttgtaac 18600 ccgtcctagc cgcgcgtccc tgcgccgcgc cgccagcggt ccgcgatcgt tgcggcccgt 18660 agccagtggc aactggcaaa gcacactgaa cagcatcgtg ggtctggggg tgcaatccct 18720 gaagcgccga cgatgcttct gaatagctaa cgtgtcgtat gtgtgtcatg tatgcgtcca 18780 tgtcgccgcc agaggagctg ctgagccgcc gcgcgcccgc tttccaagat ggctacccct 18840 tcgatgatgc cgcagtggtc ttacatgcac atctcgggcc aggacgcctc ggagtacctg 18900 agccccgggc tggtgcagtt tgcccgcgcc accgagacgt acttcagcct gaataacaag 18960 tttagaaacc ccacggtggc gcctacgcac gacgtgacca cagaccggtc ccagcgtttg 19020 acgctgcggt tcatccctgt ggaccgtgag gatactgcgt actcgtacaa ggcgcggttc 19080 accctagctg tgggtgataa ccgtgtgctg gacatggctt ccacgtactt tgacatccgc 19140 ggcgtgctgg acaggggccc tacttttaag ccctactctg gcactgccta caacgccctg 19200 gctcccaagg gtgccccaaa tccttgcgaa tgggatgaag ctgctactgc tcttgaaata 19260 aacctagaag aagaggacga tgacaacgaa gacgaagtag acgagcaagc tgagcagcaa 19320 aaaactcacg tatttgggca ggcgccttat tctggtataa atattacaaa ggagggtatt 19380 caaataggtg tcgaaggtca aacacctaaa tatgccgata aaacatttca acctgaacct 19440 caaataggag aatctcagtg gtacgaaact gaaattaatc atgcagctgg gagagtcctt 19500 aaaaagacta ccccaatgaa accatgttac ggttcatatg caaaacccac aaatgaaaat 19560 ggagggcaag gcattcttgt aaagcaacaa aatggaaagc tagaaagtca agtggaaatg 19620 caatttttct caactactga ggcgaccgca ggcaatggtg ataacttgac tcctaaagtg 19680 gtattgtaca gtgaagatgt agatatagaa accccagaca ctcatatttc ttacatgccc 19740 actattaagg aaggtaactc acgagaacta atgggccaac aatctatgcc caacaggcct 19800 aattacattg cttttaggga caattttatt ggtctaatgt attacaacag cacgggtaat 19860 atgggtgttc tggcgggcca agcatcgcag ttgaatgctg ttgtagattt gcaagacaga 19920 aacacagagc tttcatacca gcttttgctt gattccattg gtgatagaac caggtacttt 19980 tctatgtgga atcaggctgt tgacagctat gatccagatg ttagaattat tgaaaatcat 20040 ggaactgaag atgaacttcc aaattactgc tttccactgg gaggtgtgat taatacagag 20100 actcttacca aggtaaaacc taaaacaggt caggaaaatg gatgggaaaa agatgctaca 20160 gaattttcag ataaaaatga aataagagtt ggaaataatt ttgccatgga aatcaatcta 20220 aatgccaacc tgtggagaaa tttcctgtac tccaacatag cgctgtattt gcccgacaag 20280 ctaaagtaca gtccttccaa cgtaaaaatt tctgataacc caaacaccta cgactacatg 20340 aacaagcgag tggtggctcc cgggttagtg gactgctaca ttaaccttgg agcacgctgg 20400 tcccttgact atatggacaa cgtcaaccca tttaaccacc accgcaatgc tggcctgcgc 20460 taccgctcaa tgttgctggg caatggtcgc tatgtgccct tccacatcca ggtgcctcag 20520 aagttctttg ccattaaaaa cctccttctc ctgccgggct catacaccta cgagtggaac 20580 ttcaggaagg atgttaacat ggttctgcag agctccctag gaaatgacct aagggttgac 20640 ggagccagca ttaagtttga tagcatttgc ctttacgcca ccttcttccc catggcccac 20700 aacaccgcct ccacgcttga ggccatgctt agaaacgaca ccaacgacca gtcctttaac 20760 gactatctct ccgccgccaa catgctctac cctatacccg ccaacgctac caacgtgccc 20820 atatccatcc cctcccgcaa ctgggcggct ttccgcggct gggccttcac gcgccttaag 20880 actaaggaaa ccccatcact gggctcgggc tacgaccctt attacaccta ctctggctct 20940 ataccctacc tagatggaac cttttacctc aaccacacct ttaagaaggt ggccattacc 21000 tttgactctt ctgtcagctg gcctggcaat gaccgcctgc ttacccccaa cgagtttgaa 21060 attaagcgct cagttgacgg ggagggttac aacgttgccc agtgtaacat gaccaaagac 21120 tggttcctgg tacaaatgct agctaactac aacattggct accagggctt ctatatccca 21180 gagagctaca aggaccgcat gtactccttc tttagaaact tccagcccat gagccgtcag 21240 gtggtggatg atactaaata caaggactac caacaggtgg gcatcctaca ccaacacaac 21300 aactctggat ttgttggcta ccttgccccc accatgcgcg aaggacaggc ctaccctgct 21360 aacttcccct atccgcttat aggcaagacc gcagttgaca gcattaccca gaaaaagttt 21420 ctttgcgatc gcaccctttg gcgcatccca ttctccagta actttatgtc catgggcgca 21480 ctcacagacc tgggccaaaa ccttctctac gccaactccg cccacgcgct agacatgact 21540 tttgaggtgg atcccatgga cgagcccacc cttctttatg ttttgtttga agtctttgac 21600 gtggtccgtg tgcaccggcc gcaccgcggc gtcatcgaaa ccgtgtacct gcgcacgccc 21660 ttctcggccg gcaacgccac aacataaaga agcaagcaac atcaacaaca gctgccgcca 21720 tgggctccag tgagcaggaa ctgaaagcca ttgtcaaaga tcttggttgt gggccatatt 21780 ttttgggcac ctatgacaag cgctttccag gctttgtttc tccacacaag ctcgcctgcg 21840 ccatagtcaa tacggccggt cgcgagactg ggggcgtaca ctggatggcc tttgcctgga 21900 acccgcactc aaaaacatgc tacctctttg agccctttgg cttttctgac cagcgactca 21960 agcaggttta ccagtttgag tacgagtcac tcctgcgccg tagcgccatt gcttcttccc 22020 ccgaccgctg tataacgctg gaaaagtcca cccaaagcgt acaggggccc aactcggccg 22080 cctgtggact attctgctgc atgtttctcc acgcctttgc caactggccc caaactccca 22140 tggatcacaa ccccaccatg aaccttatta ccggggtacc caactccatg ctcaacagtc 22200 cccaggtaca gcccaccctg cgtcgcaacc aggaacagct ctacagcttc ctggagcgcc 22260 actcgcccta cttccgcagc cacagtgcgc agattaggag cgccacttct ttttgtcact 22320 tgaaaaacat gtaaaaataa tgtactagag acactttcaa taaaggcaaa tgcttttatt 22380 tgtacactct cgggtgatta tttaccccca cccttgccgt ctgcgccgtt taaaaatcaa 22440 aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga tactggtgtt 22500 tagtgctcca cttaaactca ggcacaacca tccgcggcag ctcggtgaag ttttcactcc 22560 acaggctgcg caccatcacc aacgcgttta gcaggtcggg cgccgatatc ttgaagtcgc 22620 agttggggcc tccgccctgc gcgcgcgagt tgcgatacac agggttgcag cactggaaca 22680 ctatcagcgc cgggtggtgc acgctggcca gcacgctctt gtcggagatc agatccgcgt 22740 ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt tggtagctgc cttcccaaaa 22800 agggcgcgtg cccaggcttt gagttgcact cgcaccgtag tggcatcaaa aggtgaccgt 22860 gcccggtctg ggcgttagga tacagcgcct gcataaaagc cttgatctgc ttaaaagcca 22920 cctgagcctt tgcgccttca gagaagaaca tgccgcaaga cttgccggaa aactgattgg 22980 ccggacaggc cgcgtcgtgc acgcagcacc ttgcgtcggt gttggagatc tgcaccacat 23040 ttcggcccca ccggttcttc acgatcttgg ccttgctaga ctgctccttc agcgcgcgct 23100 gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc cttatttatc ataatgcttc 23160 cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg gtgcagccac aacgcgcagc 23220 ccgtgggctc gtgatgcttg taggtcacct ctgcaaacga ctgcaggtac gcctgcagga 23280 atcgccccat catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc aacccgcggt 23340 gctcctcgtt cagccaggtc ttgcatacgg ccgccagagc ttccacttgg tcaggcagta 23400 gtttgaagtt cgcctttaga tcgttatcca cgtggtactt gtccatcagc gcgcgcgcag 23460 cctccatgcc cttctcccac gcagacacga tcggcacact cagcgggttc atcaccgtaa 23520 tttcactttc cgcttcgctg ggctcttcct cttcctcttg cgtccgcata ccacgcgcca 23580 ctgggtcgtc ttcattcagc cgccgcactg tgcgcttacc tcctttgcca tgcttgatta 23640 gcaccggtgg gttgctgaaa cccaccattt gtagcgccac atcttctctt tcttcctcgc 23700 tgtccacgat tacctctggt gatggcgggc gctcgggctt gggagaaggg cgcttctttt 23760 tcttcttggg cgcaatggcc aaatccgccg ccgaggtcga tggccgcggg ctgggtgtgc 23820 gcggcaccag cgcgtcttgt gatgagtctt cctcgtcctc ggactcgata cgccgcctca 23880 tccgcttttt tgggggcgcc cggggaggcg gcggcgacgg ggacggggac gacacgtcct 23940 ccatggttgg gggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt tcgcgctgct 24000 cctcttcccg actggccatt tccttctcct ataggcagaa aaagatcatg gagtcagtcg 24060 agaagaagga cagcctaacc gccccctctg agttcgccac caccgcctcc accgatgccg 24120 ccaacgcgcc taccaccttc cccgtcgagg cacccccgct tgaggaggag gaagtgatta 24180 tcgagcagga cccaggtttt gtaagcgaag acgacgagga ccgctcagta ccaacagagg 24240 ataaaaagca agaccaggac aacgcagagg caaacgagga acaagtcggg cggggggacg 24300 aaaggcatgg cgactaccta gatgtgggag acgacgtgct gttgaagcat ctgcagcgcc 24360 agtgcgccat tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc gccatagcgg 24420 atgtcagcct tgcctacgaa cgccacctat tctcaccgcg cgtacccccc aaacgccaag 24480 aaaacggcac atgcgagccc aacccgcgcc tcaacttcta ccccgtattt gccgtgccag 24540 aggtgcttgc cacctatcac atctttttcc aaaactgcaa gataccccta tcctgccgtg 24600 ccaaccgcag ccgagcggac aagcagctgg ccttgcggca gggcgctgtc atacctgata 24660 tcgcctcgct caacgaagtg ccaaaaatct ttgagggtct tggacgcgac gagaagcgcg 24720 cggcaaacgc tctgcaacag gaaaacagcg aaaatgaaag tcactctgga gtgttggtgg 24780 aactcgaggg tgacaacgcg cgcctagccg tactaaaacg cagcatcgag gtcacccact 24840 ttgcctaccc ggcacttaac ctacccccca aggtcatgag cacagtcatg agtgagctga 24900 tcgtgcgccg tgcgcagccc ctggagaggg atgcaaattt gcaagaacaa acagaggagg 24960 gcctacccgc agttggcgac gagcagctag cgcgctggct tcaaacgcgc gagcctgccg 25020 acttggagga gcgacgcaaa ctaatgatgg ccgcagtgct cgttaccgtg gagcttgagt 25080 gcatgcagcg gttctttgct gacccggaga tgcagcgcaa gctagaggaa acattgcact 25140 acacctttcg acagggctac gtacgccagg cctgcaagat ctccaacgtg gagctctgca 25200 acctggtctc ctaccttgga attttgcacg aaaaccgcct tgggcaaaac gtgcttcatt 25260 ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac ttatttctat 25320 gctacacctg gcagacggcc atgggcgttt ggcagcagtg cttggaggag tgcaacctca 25380 aggagctgca gaaactgcta aagcaaaact tgaaggacct atggacggcc ttcaacgagc 25440 gctccgtggc cgcgcacctg gcggacatca ttttccccga acgcctgctt aaaaccctgc 25500 aacagggtct gccagacttc accagtcaaa gcatgttgca gaactttagg aactttatcc 25560 tagagcgctc aggaatcttg cccgccacct gctgtgcact tcctagcgac tttgtgccca 25620 ttaagtaccg cgaatgccct ccgccgcttt ggggccactg ctaccttctg cagctagcca 25680 actaccttgc ctaccactct gacataatgg aagacgtgag cggtgacggt ctactggagt 25740 gtcactgtcg ctgcaaccta tgcaccccgc accgctccct ggtttgcaat tcgcagctgc 25800 ttaacgaaag tcaaattatc ggtacctttg agctgcaggg tccctcgcct gacgaaaagt 25860 ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac gtcggcttac cttcgcaaat 25920 ttgtacctga ggactaccac gcccacgaga ttaggttcta cgaagaccaa tcccgcccgc 25980 caaatgcgga gcttaccgcc tgcgtcatta cccagggcca cattcttggc caattgcaag 26040 ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg acggggggtt tacttggacc 26100 cccagtccgg cgaggagctc aacccaatcc ccccgccgcc gcagccctat cagcagcagc 26160 cgcgggccct tgcttcccag gatggcaccc aaaaagaagc tgcagctgcc gccgccaccc 26220 acggacgagg aggaatactg ggacagtcag gcagaggagg ttttggacga ggaggaggag 26280 gacatgatgg aagactggga gagcctagac gaggaagctt ccgaggtcga agaggtgtca 26340 gacgaaacac cgtcaccctc ggtcgcattc ccctcgccgg cgccccagaa atcggcaacc 26400 ggttccagca tggctacaac ctccgctcct caggcgccgc cggcactgcc cgttcgccga 26460 cccaaccgta gatgggacac cactggaacc agggccggta agtccaagca gccgccgccg 26520 ttagcccaag agcaacaaca gcgccaaggc taccgctcat ggcgcgggca caagaacgcc 26580 atagttgctt gcttgcaaga ctgtgggggc aacatctcct tcgcccgccg ctttcttctc 26640 taccatcacg gcgtggcctt cccccgtaac atcctgcatt actaccgtca tctctacagc 26700 ccatactgca ccggcggcag cggcagcggc agcaacagca gcggccacac agaagcaaag 26760 gcgaccggat agcaagactc tgacaaagcc caagaaatcc acagcggcgg cagcagcagg 26820 aggaggagcg ctgcgtctgg cgcccaacga acccgtatcg acccgcgagc ttagaaacag 26880 gatttttccc actctgtatg ctatatttca acagagcagg ggccaagaac aagagctgaa 26940 aataaaaaac aggtctctgc gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga 27000 tcagcttcgg cgcacgctgg aagacgcgga ggctctcttc agtaaatact gcgcgctgac 27060 tcttaaggac tagtttcgcg ccctttctca aatttaagcg cgaaaactac gtcatctcca 27120 gcggccacac ccggcgccag cacctgtcgt cagcgccatt tatgagcaag gaaattccca 27180 cgccctacat gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact 27240 actcaacccg aataaactac atgagcgcgg gaccccacat gatatcccgg gtcaacggaa 27300 tacgcgccca ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta 27360 ataaccttaa tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca 27420 ccactgtggt acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc 27480 agcttgcggg cggctttcgt cacagggtgc ggtcgcccgg gcagggtata actcacctga 27540 caatcagagg gcgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc 27600 gtccggacgg gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg 27660 caatcctaac tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactctgc 27720 aatttattga ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc 27780 actatccgga tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg 27840 actgaatgtt aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc 27900 gccacaagtg ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc 27960 atatcgaggg cccggcgcac ggcgtccggc ttaccgccca gggagagctt gcccgtagcc 28020 tgattcggga gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc 28080 tcactgtgat ttgcaactgt cctaaccctg gattacatca agatctttgt tgccatctct 28140 gtgctgagta taataaatac agaaattaaa atatactggg gctcctatcg ccatcctgta 28200 aacgccaccg tcttcacccg cccaagcaaa ccaaggcgaa ccttacctgg tacttttaac 28260 atctctccct ctgtgattta caacagtttc aacccagacg gagtgagtct acgagagaac 28320 ctctccgagc tcagctactc catcagaaaa aacaccaccc tccttacctg ccgggaacgt 28380 acgagtgcgt caccggccgc tgcaccacac ctaccgcctg accgtaaacc agactttttc 28440 cggacagacc tcaataactc tgtttaccag aacaggaggt gagcttagaa aacccttagg 28500 gtattaggcc aaaggcgcag ctactgtggg gtttatgaac aattcaagca actctacggg 28560 ctattctaat tcaggtttct ctagaatcgg ggttggggtt attctctgtc ttgtgattct 28620 ctttattctt atactaacgc ttctctgcct aaggctcgcc gcctgctgtg tgcacatttg 28680 catttattgt cagcttttta aacgctgggg tcgccaccca agatgattag gtacataatc 28740 ctaggtttac tcacccttgc gtcagcccac ggtaccaccc aaaaggtgga ttttaaggag 28800 ccagcctgta atgttacatt cgcagctgaa gctaatgagt gcaccactct tataaaatgc 28860 accacagaac atgaaaagct gcttattcgc cacaaaaaca aaattggcaa gtatgctgtt 28920 tatgctattt ggcagccagg tgacactaca gagtataatg ttacagtttt ccagggtaaa 28980 agtcataaaa cttttatgta tacttttcca ttttatgaaa tgtgcgacat taccatgtac 29040 atgagcaaac agtataagtt gtggccccca caaaattgtg tggaaaacac tggcactttc 29100 tgctgcactg ctatgctaat tacagtgctc gctttggtct gtaccctact ctatattaaa 29160 tacaaaagca gacgcagctt tattgaggaa aagaaaatgc cttaatttac taagttacaa 29220 agctaatgtc accactaact gctttactcg ctgcttgcaa aacaaattca aaaagttagc 29280 attataatta gaataggatt taaacccccc ggtcatttcc tgctcaatac cattcccctg 29340 aacaattgac tctatgtggg atatgctcca gcgctacaac cttgaagtca ggcttcctgg 29400 atgtcagcat ctgactttgg ccagcacctg tcccgcggat ttgttccagt ccaactacag 29460 cgacccaccc taacagagat gaccaacaca accaacgcgg ccgccgctac cggacttaca 29520 tctaccacaa atacacccca agtttctgcc tttgtcaata actgggataa cttgggcatg 29580 tggtggttct ccatagcgct tatgtttgta tgccttatta ttatgtggct catctgctgc 29640 ctaaagcgca aacgcgcccg accacccatc tatagtccca tcattgtgct acacccaaac 29700 aatgatggaa tccatagatt ggacggactg aaacacatgt tcttttctct tacagtatga 29760 ttaaatgaga catgattcct cgagttttta tattactgac ccttgttgcg cttttttgtg 29820 cgtgctccac attggctgcg gtttctcaca tcgaagtaga ctgcattcca gccttcacag 29880 tctatttgct ttacggattt gtcaccctca cgctcatctg cagcctcatc actgtggtca 29940 tcgcctttat ccagtgcatt gactgggtct gtgtgcgctt tgcatatctc agacaccatc 30000 cccagtacag ggacaggact atagctgagc ttcttagaat tctttaatta tgaaatttac 30060 tgtgactttt ctgctgatta tttgcaccct atctgcgttt tgttccccga cctccaagcc 30120 tcaaagacat atatcatgca gattcactcg tatatggaat attccaagtt gctacaatga 30180 aaaaagcgat ctttccgaag cctggttata tgcaatcatc tctgttatgg tgttctgcag 30240 taccatctta gccctagcta tatatcccta ccttgacatt ggctggaacg caatagatgc 30300 catgaaccac ccaactttcc ccgcgcccgc tatgcttcca ctgcaacaag ttgttgccgg 30360 cggctttgtc ccagccaatc agcctcgccc accttctccc acccccactg aaatcagcta 30420 ctttaatcta acaggaggag atgactgaca ccctagatct agaaatggac ggaattatta 30480 cagagcagcg cctgctagaa agacgcaggg cagcggccga gcaacagcgc atgaatcaag 30540 agctccaaga catggttaac ttgcaccagt gcaaaagggg tatcttttgt ctggtaaagc 30600 aggccaaagt cacctacgac agtaatacca ccggacaccg ccttagctac aagttgccaa 30660 ccaagcgtca gaaattggtg gtcatggtgg gagaaaagcc cattaccata actcagcact 30720 cggtagaaac cgaaggctgc attcactcac cttgtcaagg acctgaggat ctctgcaccc 30780 ttattaagac cctgtgcggt ctcaaagatc ttattccctt taactaataa aaaaaaataa 30840 taaagcatca cttacttaaa atcagttagc aaatttctgt ccagtttatt cagcagcacc 30900 tccttgccct cctcccagct ctggtattgc agcttcctcc tggctgcaaa ctttctccac 30960 aatctaaatg gaatgtcagt ttcctcctgt tcctgtccat ccgcacccac tatcttcatg 31020 ttgttgcaga tgaagcgcgc aagaccgtct gaagatacct tcaaccccgt gtatccatat 31080 gacacggaaa ccggtcctcc aactgtgcct tttcttactc ctccctttgt atcccccaat 31140 gggtttcaag agagtccccc tggggtactc tctttgcgcc tatccgaacc tctagttacc 31200 tccaatggca tgcttgcgct caaaatgggc aacggcctct ctctggacga ggccggcaac 31260 cttacctccc aaaatgtaac cactgtgagc ccacctctca aaaaaaccaa gtcaaacata 31320 aacctggaaa tatctgcacc cctcacagtt acctcagaag ccctaactgt ggctgccgcc 31380 gcacctctaa tggtcgcggg caacacactc accatgcaat cacaggcccc gctaaccgtg 31440 cacgactcca aacttagcat tgccacccaa ggacccctca cagtgtcaga aggaaagcta 31500 gccctgcaaa catcaggccc cctcaccacc accgatagca gtacccttac tatcactgcc 31560 tcaccccctc taactactgc cactggtagc ttgggcattg acttgaaaga gcccatttat 31620 acacaaaatg gaaaactagg actaaagtac ggggctcctt tgcatgtaac agacgaccta 31680 aacactttga ccgtagcaac tggtccaggt gtgactatta ataatacttc cttgcaaact 31740 aaagttactg gagccttggg ttttgattca caaggcaata tgcaacttaa tgtagcagga 31800 ggactaagga ttgattctca aaacagacgc cttatacttg atgttagtta tccgtttgat 31860 gctcaaaacc aactaaatct aagactagga cagggccctc tttttataaa ctcagcccac 31920 aacttggata ttaactacaa caaaggcctt tacttgttta cagcttcaaa caattccaaa 31980 aagcttgagg ttaacctaag cactgccaag gggttgatgt ttgacgctac agccatagcc 32040 attaatgcag gagatgggct tgaatttggt tcacctaatg caccaaacac aaatcccctc 32100 aaaacaaaaa ttggccatgg cctagaattt gattcaaaca aggctatggt tcctaaacta 32160 ggaactggcc ttagttttga cagcacaggt gccattacag taggaaacaa aaataatgat 32220 aagctaactt tgtggaccac accagctcca tctcctaact gtagactaaa tgcagagaaa 32280 gatgctaaac tcactttggt cttaacaaaa tgtggcagtc aaatacttgc tacagtttca 32340 gttttggctg ttaaaggcag tttggctcca atatctggaa cagttcaaag tgctcatctt 32400 attataagat ttgacgaaaa tggagtgcta ctaaacaatt ccttcctgga cccagaatat 32460 tggaacttta gaaatggaga tcttactgaa ggcacagcct atacaaacgc tgttggattt 32520 atgcctaacc tatcagctta tccaaaatct cacggtaaaa ctgccaaaag taacattgtc 32580 agtcaagttt acttaaacgg agacaaaact aaacctgtaa cactaaccat tacactaaac 32640 ggtacacagg aaacaggaga cacaactcca agtgcatact ctatgtcatt ttcatgggac 32700 tggtctggcc acaactacat taatgaaata tttgccacat cctcttacac tttttcatac 32760 attgcccaag aataaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca 32820 gaaaatttcg aatcattttt cattcagtag tatagcccca ccaccacata gcttatacag 32880 atcaccgtac cttaatcaaa cctacatggg ggtagagtca taatcgtgca tcaggatagg 32940 gcggtggtgc tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga 33000 atacaacatg gcagtggtct cctcagcgat gattcgcacc gcccgcagca taaggcgcct 33060 tgtcctccgg gcacagcagc gcaccctgat ctcacttaaa tcagcacagt aactgcagca 33120 cagcaccaca atattgttca aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc 33180 ggggaccaca gaacccacgt ggccatcata ccacaagcgc aggtagatta agtggcgacc 33240 cctcataaac acgctggaca taaacattac ctcttttggc atgttgtaat tcaccacctc 33300 ccggtaccat ataaacctct gattaaacat ggcgccatcc accaccatcc taaaccagct 33360 ggccaaaacc tgcccgccgg ctatacactg cagggaaccg ggactggaac aatgacagtg 33420 gagagcccag gactcgtaac catggatcat catgctcgtc atgatatcaa tgttggcaca 33480 acacaggcac acgtgcatac acttcctcag gattacaagc tcctcccgcg ttagaaccat 33540 atcccaggga acaacccatt cctgaatcag cgtaaatccc acactgcagg gaagacctcg 33600 cacgtaactc acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc 33660 cagtatggta gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac tgtacggagt 33720 gcgccgagac aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt 33780 agtcatattt cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg cgtctccggt 33840 ctcgccgctt agatcgctct gtgtagtagt tgtagtatat ccactctctc aaagcatcca 33900 ggcgccccct ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc ctgataacat 33960 ccaccaccgc agaataagcc acacccagcc aacctacaca ttcgttctgc gagtcacaca 34020 cgggaggagc gggaagagct ggaagaacca tgtttttttt tttattccaa aagattatcc 34080 aaaacctcaa aatgaagatc tattaagtga acgcgctccc ctccggtggc gtggtcaaac 34140 tctacagcca aagaacagat aatggcattt gtaagatgtt gcacaatggc ttccaaaagg 34200 caaacggccc tcacgtccaa gtggacgtaa aggctaaacc cttcagggtg aatctcctct 34260 ataaacattc cagcaccttc aaccatgccc aaataattct catctcgcca ccttctcaat 34320 atatctctaa gcaaatcccg aatattaagt ccggccattg taaaaatctg ctccagagcg 34380 ccctccacct tcagcctcaa gcagcgaatc atgattgcaa aaattcaggt tcctcacaga 34440 cctgtataag attcaaaagc ggaacattaa caaaaatacc gcgatcccgt aggtcccttc 34500 gcagggccag ctgaacataa tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc 34560 caggaaccat gacaaaagaa cccacactga ttatgacacg catactcgga gctatgctaa 34620 ccagcgtagc cccgatgtaa gcttgttgca tgggcggcga tataaaatgc aaggtgctgc 34680 tcaaaaaatc aggcaaagcc tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca 34740 gataaaggca ggtaagctcc ggaaccacca cagaaaaaga caccattttt ctctcaaaca 34800 tgtctgcggg tttctgcata aacacaaaat aaaataacaa aaaaacattt aagcctgtct 34860 tacaacagga aaaacaaccc ttataagcat aagacggact acggccatgc cggcgtgacc 34920 gtaaaaaaac tggtcaccgt gattaaaaag caccaccgac agctcctcgg tcatgtccgg 34980 agtcataatg taagactcgg taaacacatc aggttgattc acatcggtca gtgctaaaaa 35040 gcgaccgaaa tagcccgggg gaatacatac ccgcaggcgt agagacaaca ttacagcccc 35100 cataggaggt ataacaaaat taataggaga gaaaaacaca taaacacctg aaaaaccctc 35160 ctgcctaggc aaaatagcac cctcccgctc cagaacaaca tacagcgctt ccacagcggc 35220 agccataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac 35280 acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc gagtatatat 35340 aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg 35400 aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg tcacttccgt 35460 tttcccacgt tacgtcactt cccattttaa gaaaactaca attcccaaca catacaagtt 35520 actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac 35580 tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat tgatgatg 35638 <210> 8 <211> 35213 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO286) <400> 8 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagca taagtgtctt gctgtcttta 4080 tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct 4140 gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag 4200 cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta 4260 gatgatccag tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa 4320 gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg 4380 gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc 4440 agccatatcc ctccggggat tcatgttgtg cagaaccacc agcacagtgt atccggtgca 4500 cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt 4560 gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc 4620 ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc 4680 gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcggta taatggttcc 4740 atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga 4800 tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg taggggagat 4860 cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta 4920 aatcacacct attaccgggt gcaactggta gttaagagag ctgcagctgc cgtcatccct 4980 gagcaggggg gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc 5040 cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa 5100 cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg 5160 gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc 5220 gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc 5280 atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc 5340 gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc 5400 tgccggtctt cgccctgcgc gtcggccagg tagcatttga ccatggtgtc atagtccagc 5460 ccctccgcgg cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg 5520 cagtgcagac ttttgagggc gtagagcttg ggcgcgagaa ataccgattc cggggagtag 5580 gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc 5640 cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt 5700 tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac 5760 ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac 5820 tctgagacaa aggctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg 5880 tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg 5940 gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg 6000 gggctataaa agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg 6060 agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga 6120 ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg 6180 agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca 6240 aacgacccgt agagggcgtt ggacagcaac ttggcgatgg agcgcagggt ttggtttttg 6300 tcgcgatcgg cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac 6360 cgccattcgg gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg 6420 ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc 6480 cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg 6540 tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct 6600 atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg 6660 tatgggttga gtgggggacc ccatggcatg gggtgggtga gcgcggaggc gtacatgccg 6720 caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt 6780 ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg 6840 ggaccgaggt tgctacgggc gggctgctct gctcggaaga ctatctgcct gaagatggca 6900 tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct 6960 accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg 7020 acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt 7080 cccttttttt tccacagctc gcggttgagg acaaactctt cgcggtcttt ccagtactct 7140 tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg 7200 gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg 7260 agcgaggtgt gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg 7320 aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa 7380 cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata 7440 aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg 7500 gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag ttccaagaag 7560 cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg 7620 gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat 7680 gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg 7740 cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag 7800 cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg 7860 ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta 7920 taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg 7980 aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag 8040 tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag 8100 cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag 8160 agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct 8220 tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc 8280 gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga 8340 tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg 8400 tttacctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg 8460 ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg 8520 gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt 8580 gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg 8640 gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg 8700 cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg 8760 tgagcttgag cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct 8820 ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact 8880 gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt 8940 cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc 9000 ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga 9060 gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg 9120 tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt 9180 tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga 9240 aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg 9300 cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct 9360 cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac 9420 ggcggcgacg acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc 9480 gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc 9540 cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc 9600 taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt 9660 ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 9720 gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg 9780 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca 9840 ccatgtcctt gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt 9900 tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt 9960 cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg 10020 gccgtaggtg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa 10080 gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg 10140 tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag 10200 tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt 10260 acctgagacg cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt 10320 actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg 10380 ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg 10440 acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc 10500 agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg gtcaggcgcg 10560 cgcaatcgtt gacgctctag accgtgcaaa aggagagcct gtaagcgggc actcttccgt 10620 ggtctggtgg ataaattcgc aagggtatca tggcggacga ccggggttcg agccccgtat 10680 ccggccgtcc gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg 10740 tcagacaacg ggggagtgct ccttttggct tccttccagg cgcggcggct gctgcgctag 10800 cttttttggc cactggccgc gcgcagcgta agcggttagg ctggaaagcg aaagcattaa 10860 gtggctcgct ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg ggacccccgg 10920 ttcgagtctc ggaccggccg gactgcggcg aacgggggtt tgcctccccg tcatgcaaga 10980 ccccgcttgc aaattcctcc ggaaacaggg acgagcccct tttttgcttt tcccagatgc 11040 atccggtgct gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc 11100 agacatgcag ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca tccgcggttg 11160 acgcggcagc agatggtgat tacgaacccc cgcggcgccg ggcccggcac tacctggact 11220 tggaggaggg cgagggcctg gcgcggctag gagcgccctc tcctgagcgg tacccaaggg 11280 tgcagctgaa gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc 11340 gcgagggaga ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc 11400 ggcatggcct gaatcgcgag cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa 11460 ccgggattag tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc gcatacgagc 11520 agacggtgaa ccaggagatt aactttcaaa aaagctttaa caaccacgtg cgtacgcttg 11580 tggcgcgcga ggaggtggct ataggactga tgcatctgtg ggactttgta agcgcgctgg 11640 agcaaaaccc aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg cagcacagca 11700 gggacaacga ggcattcagg gatgcgctgc taaacatagt agagcccgag ggccgctggc 11760 tgctcgattt gataaacatc ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg 11820 ctgacaaggt ggccgccatc aactattcca tgcttagcct gggcaagttt tacgcccgca 11880 agatatacca taccccttac gttcccatag acaaggaggt aaagatcgag gggttctaca 11940 tgcgcatggc gctgaaggtg cttaccttga gcgacgacct gggcgtttat cgcaacgagc 12000 gcatccacaa ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc 12060 acagcctgca aagggccctg gctggcacgg gcagcggcga tagagaggcc gagtcctact 12120 ttgacgcggg cgctgacctg cgctgggccc caagccgacg cgccctggag gcagctgggg 12180 ccggacctgg gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat 12240 atgacgagga cgatgagtac gagccagagg acggcgagta ctaagcggtg atgtttctga 12300 tcagatgatg caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc 12360 cggccttaac tccacggacg actggcgcca ggtcatggac cgcatcatgt cgctgactgc 12420 gcgcaatcct gacgcgttcc ggcagcagcc gcaggccaac cggctctccg caattctgga 12480 agcggtggtc ccggcgcgcg caaaccccac gcacgagaag gtgctggcga tcgtaaacgc 12540 gctggccgaa aacagggcca tccggcccga cgaggccggc ctggtctacg acgcgctgct 12600 tcagcgcgtg gctcgttaca acagcggcaa cgtgcagacc aacctggacc ggctggtggg 12660 ggatgtgcgc gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca acctgggctc 12720 catggttgca ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc ggggacagga 12780 ggactacacc aactttgtga gcgcactgcg gctaatggtg actgagacac cgcaaagtga 12840 ggtgtaccag tctgggccag actatttttt ccagaccagt agacaaggcc tgcagaccgt 12900 aaacctgagc caggctttca aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg 12960 cgaccgcgcg accgtgtcta gcttgctgac gcccaactcg cgcctgttgc tgctgctaat 13020 agcgcccttc acggacagtg gcagcgtgtc ccgggacaca tacctaggtc acttgctgac 13080 actgtaccgc gaggccatag gtcaggcgca tgtggacgag catactttcc aggagattac 13140 aagtgtcagc cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa ccctaaacta 13200 cctgctgacc aaccggcggc agaagatccc ctcgttgcac agtttaaaca gcgaggagga 13260 gcgcattttg cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg acggggtaac 13320 gcccagcgtg gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa 13380 ccggccgttt atcaaccgcc taatggacta cttgcatcgc gcggccgccg tgaaccccga 13440 gtatttcacc aatgccatct tgaacccgca ctggctaccg ccccctggtt tctacaccgg 13500 gggattcgag gtgcccgagg gtaacgatgg attcctctgg gacgacatag acgacagcgt 13560 gttttccccg caaccgcaga ccctgctaga gttgcaacag cgcgagcagg cagaggcggc 13620 gctgcgaaag gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc 13680 gcggtcagat gctagtagcc catttccaag cttgataggg tctcttacca gcactcgcac 13740 cacccgcccg cgcctgctgg gcgaggagga gtacctaaac aactcgctgc tgcagccgca 13800 gcgcgaaaaa aacctgcctc cggcatttcc caacaacggg atagagagcc tagtggacaa 13860 gatgagtaga tggaagacgt acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc 13920 cacccgtcgt caaaggcacg accgtcagcg gggtctggtg tgggaggacg atgactcggc 13980 agacgacagc agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc accttcgccc 14040 caggctgggg agaatgtttt aaaaaaaaaa aagcatgatg caaaataaaa aactcaccaa 14100 ggccatggca ccgagcgttg gttttcttgt attcccctta gtatgcggcg cgcggcgatg 14160 tatgaggaag gtcctcctcc ctcctacgag agtgtggtga gcgcggcgcc agtggcggcg 14220 gcgctgggtt ctcccttcga tgctcccctg gacccgccgt ttgtgcctcc gcggtacctg 14280 cggcctaccg gggggagaaa cagcatccgt tactctgagt tggcacccct attcgacacc 14340 acccgtgtgt acctggtgga caacaagtca acggatgtgg catccctgaa ctaccagaac 14400 gaccacagca actttctgac cacggtcatt caaaacaatg actacagccc gggggaggca 14460 agcacacaga ccatcaatct tgacgaccgg tcgcactggg gcggcgacct gaaaaccatc 14520 ctgcatacca acatgccaaa tgtgaacgag ttcatgttta ccaataagtt taaggcgcgg 14580 gtgatggtgt cgcgcttgcc tactaaggac aatcaggtgg agctgaaata cgagtgggtg 14640 gagttcacgc tgcccgaggg caactactcc gagaccatga ccatagacct tatgaacaac 14700 gcgatcgtgg agcactactt gaaagtgggc agacagaacg gggttctgga aagcgacatc 14760 ggggtaaagt ttgacacccg caacttcaga ctggggtttg accccgtcac tggtcttgtc 14820 atgcctgggg tatatacaaa cgaagccttc catccagaca tcattttgct gccaggatgc 14880 ggggtggact tcacccacag ccgcctgagc aacttgttgg gcatccgcaa gcggcaaccc 14940 ttccaggagg gctttaggat cacctacgat gatctggagg gtggtaacat tcccgcactg 15000 ttggatgtgg acgcctacca ggcgagcttg aaagatgaca ccgaacaggg cgggggtggc 15060 gcaggcggca gcaacagcag tggcagcggc gcggaagaga actccaacgc ggcagccgcg 15120 gcaatgcagc cggtggagga catgaacgat catgccattc gcggcgacac ctttgccaca 15180 cgggctgagg agaagcgcgc tgaggccgaa gcagcggccg aagctgccgc ccccgctgcg 15240 caacccgagg tcgagaagcc tcagaagaaa ccggtgatca aacccctgac agaggacagc 15300 aagaaacgca gttacaacct aataagcaat gacagcacct tcacccagta ccgcagctgg 15360 taccttgcat acaactacgg cgaccctcag accggaatcc gctcatggac cctgctttgc 15420 actcctgacg taacctgcgg ctcggagcag gtctactggt cgttgccaga catgatgcaa 15480 gaccccgtga ccttccgctc cacgcgccag atcagcaact ttccggtggt gggcgccgag 15540 ctgttgcccg tgcactccaa gagcttctac aacgaccagg ccgtctactc ccaactcatc 15600 cgccagttta cctctctgac ccacgtgttc aatcgctttc ccgagaacca gattttggcg 15660 cgcccgccag cccccaccat caccaccgtc agtgaaaacg ttcctgctct cacagatcac 15720 gggacgctac cgctgcgcaa cagcatcgga ggagtccagc gagtgaccat tactgacgcc 15780 agacgccgca cctgccccta cgtttacaag gccctgggca tagtctcgcc gcgcgtccta 15840 tcgagccgca ctttttgagc aagcatgtcc atccttatat cgcccagcaa taacacaggc 15900 tggggcctgc gcttcccaag caagatgttt ggcggggcca agaagcgctc cgaccaacac 15960 ccagtgcgcg tgcgcgggca ctaccgcgcg ccctggggcg cgcacaaacg cggccgcact 16020 gggcgcacca ccgtcgatga cgccatcgac gcggtggtgg aggaggcgcg caactacacg 16080 cccacgccgc caccagtgtc cacagtggac gcggccattc agaccgtggt gcgcggagcc 16140 cggcgctatg ctaaaatgaa gagacggcgg aggcgcgtag cacgtcgcca ccgccgccga 16200 cccggcactg ccgcccaacg cgcggcggcg gccctgctta accgcgcacg tcgcaccggc 16260 cgacgggcgg ccatgcgggc cgctcgaagg ctggccgcgg gtattgtcac tgtgcccccc 16320 aggtccaggc gacgagcggc cgccgcagca gccgcggcca ttagtgctat gactcagggt 16380 cgcaggggca acgtgtattg ggtgcgcgac tcggttagcg gcctgcgcgt gcccgtgcgc 16440 acccgccccc cgcgcaacta gattgcaaga aaaaactact tagactcgta ctgttgtatg 16500 tatccagcgg cggcggcgcg caacgaagct atgtccaagc gcaaaatcaa agaagagatg 16560 ctccaggtca tcgcgccgga gatctatggc cccccgaaga aggaagagca ggattacaag 16620 ccccgaaagc taaagcgggt caaaaagaaa aagaaagatg atgatgatga acttgacgac 16680 gaggtggaac tgctgcacgc taccgcgccc aggcgacggg tacagtggaa aggtcgacgc 16740 gtaaaacgtg ttttgcgacc cggcaccacc gtagtcttta cgcccggtga gcgctccacc 16800 cgcacctaca agcgcgtgta tgatgaggtg tacggcgacg aggacctgct tgagcaggcc 16860 aacgagcgcc tcggggagtt tgcctacgga aagcggcata aggacatgct ggcgttgccg 16920 ctggacgagg gcaacccaac acctagccta aagcccgtaa cactgcagca ggtgctgccc 16980 gcgcttgcac cgtccgaaga aaagcgcggc ctaaagcgcg agtctggtga cttggcaccc 17040 accgtgcagc tgatggtacc caagcgccag cgactggaag atgtcttgga aaaaatgacc 17100 gtggaacctg ggctggagcc cgaggtccgc gtgcggccaa tcaagcaggt ggcgccggga 17160 ctgggcgtgc agaccgtgga cgttcagata cccactacca gtagcaccag tattgccacc 17220 gccacagagg gcatggagac acaaacgtcc ccggttgcct cagcggtggc ggatgccgcg 17280 gtgcaggcgg tcgctgcggc cgcgtccaag acctctacgg aggtgcaaac ggacccgtgg 17340 atgtttcgcg tttcagcccc ccggcgcccg cgcggttcga ggaagtacgg cgccgccagc 17400 gcgctactgc ccgaatatgc cctacatcct tccattgcgc ctacccccgg ctatcgtggc 17460 tacacctacc gccccagaag acgagcaact acccgacgcc gaaccaccac tggaacccgc 17520 cgccgccgtc gccgtcgcca gcccgtgctg gccccgattt ccgtgcgcag ggtggctcgc 17580 gaaggaggca ggaccctggt gctgccaaca gcgcgctacc accccagcat cgtttaaaag 17640 ccggtctttg tggttcttgc agatatggcc ctcacctgcc gcctccgttt cccggtgccg 17700 ggattccgag gaagaatgca ccgtaggagg ggcatggccg gccacggcct gacgggcggc 17760 atgcgtcgtg cgcaccaccg gcggcggcgc gcgtcgcacc gtcgcatgcg cggcggtatc 17820 ctgcccctcc ttattccact gatcgccgcg gcgattggcg ccgtgcccgg aattgcatcc 17880 gtggccttgc aggcgcagag acactgatta aaaacaagtt gcatgtggaa aaatcaaaat 17940 aaaaagtctg gactctcacg ctcgcttggt cctgtaacta ttttgtagaa tggaagacat 18000 caactttgcg tctctggccc cgcgacacgg ctcgcgcccg ttcatgggaa actggcaaga 18060 tatcggcacc agcaatatga gcggtggcgc cttcagctgg ggctcgctgt ggagcggcat 18120 taaaaatttc ggttccaccg ttaagaacta tggcagcaag gcctggaaca gcagcacagg 18180 ccagatgctg agggataagt tgaaagagca aaatttccaa caaaaggtgg tagatggcct 18240 ggcctctggc attagcgggg tggtggacct ggccaaccag gcagtgcaaa ataagattaa 18300 cagtaagctt gatccccgcc ctcccgtaga ggagcctcca ccggccgtgg agacagtgtc 18360 tccagagggg cgtggcgaaa agcgtccgcg ccccgacagg gaagaaactc tggtgacgca 18420 aatagacgag cctccctcgt acgaggaggc actaaagcaa ggcctgccca ccacccgtcc 18480 catcgcgccc atggctaccg gagtgctggg ccagcacaca cccgtaacgc tggacctgcc 18540 tccccccgcc gacacccagc agaaacctgt gctgccaggc ccgaccgccg ttgttgtaac 18600 ccgtcctagc cgcgcgtccc tgcgccgcgc cgccagcggt ccgcgatcgt tgcggcccgt 18660 agccagtggc aactggcaaa gcacactgaa cagcatcgtg ggtctggggg tgcaatccct 18720 gaagcgccga cgatgcttct gaatagctaa cgtgtcgtat gtgtgtcatg tatgcgtcca 18780 tgtcgccgcc agaggagctg ctgagccgcc gcgcgcccgc tttccaagat ggctacccct 18840 tcgatgatgc cgcagtggtc ttacatgcac atctcgggcc aggacgcctc ggagtacctg 18900 agccccgggc tggtgcagtt tgcccgcgcc accgagacgt acttcagcct gaataacaag 18960 tttagaaacc ccacggtggc gcctacgcac gacgtgacca cagaccggtc ccagcgtttg 19020 acgctgcggt tcatccctgt ggaccgtgag gatactgcgt actcgtacaa ggcgcggttc 19080 accctagctg tgggtgataa ccgtgtgctg gacatggctt ccacgtactt tgacatccgc 19140 ggcgtgctgg acaggggccc tacttttaag ccctactctg gcactgccta caacgccctg 19200 gctcccaagg gtgccccaaa tccttgcgaa tgggatgaag ctgctactgc tcttgaaata 19260 aacctagaag aagaggacga tgacaacgaa gacgaagtag acgagcaagc tgagcagcaa 19320 aaaactcacg tatttgggca ggcgccttat tctggtataa atattacaaa ggagggtatt 19380 caaataggtg tcgaaggtca aacacctaaa tatgccgata aaacatttca acctgaacct 19440 caaataggag aatctcagtg gtacgaaact gaaattaatc atgcagctgg gagagtcctt 19500 aaaaagacta ccccaatgaa accatgttac ggttcatatg caaaacccac aaatgaaaat 19560 ggagggcaag gcattcttgt aaagcaacaa aatggaaagc tagaaagtca agtggaaatg 19620 caatttttct caactactga ggcgaccgca ggcaatggtg ataacttgac tcctaaagtg 19680 gtattgtaca gtgaagatgt agatatagaa accccagaca ctcatatttc ttacatgccc 19740 actattaagg aaggtaactc acgagaacta atgggccaac aatctatgcc caacaggcct 19800 aattacattg cttttaggga caattttatt ggtctaatgt attacaacag cacgggtaat 19860 atgggtgttc tggcgggcca agcatcgcag ttgaatgctg ttgtagattt gcaagacaga 19920 aacacagagc tttcatacca gcttttgctt gattccattg gtgatagaac caggtacttt 19980 tctatgtgga atcaggctgt tgacagctat gatccagatg ttagaattat tgaaaatcat 20040 ggaactgaag atgaacttcc aaattactgc tttccactgg gaggtgtgat taatacagag 20100 actcttacca aggtaaaacc taaaacaggt caggaaaatg gatgggaaaa agatgctaca 20160 gaattttcag ataaaaatga aataagagtt ggaaataatt ttgccatgga aatcaatcta 20220 aatgccaacc tgtggagaaa tttcctgtac tccaacatag cgctgtattt gcccgacaag 20280 ctaaagtaca gtccttccaa cgtaaaaatt tctgataacc caaacaccta cgactacatg 20340 aacaagcgag tggtggctcc cgggttagtg gactgctaca ttaaccttgg agcacgctgg 20400 tcccttgact atatggacaa cgtcaaccca tttaaccacc accgcaatgc tggcctgcgc 20460 taccgctcaa tgttgctggg caatggtcgc tatgtgccct tccacatcca ggtgcctcag 20520 aagttctttg ccattaaaaa cctccttctc ctgccgggct catacaccta cgagtggaac 20580 ttcaggaagg atgttaacat ggttctgcag agctccctag gaaatgacct aagggttgac 20640 ggagccagca ttaagtttga tagcatttgc ctttacgcca ccttcttccc catggcccac 20700 aacaccgcct ccacgcttga ggccatgctt agaaacgaca ccaacgacca gtcctttaac 20760 gactatctct ccgccgccaa catgctctac cctatacccg ccaacgctac caacgtgccc 20820 atatccatcc cctcccgcaa ctgggcggct ttccgcggct gggccttcac gcgccttaag 20880 actaaggaaa ccccatcact gggctcgggc tacgaccctt attacaccta ctctggctct 20940 ataccctacc tagatggaac cttttacctc aaccacacct ttaagaaggt ggccattacc 21000 tttgactctt ctgtcagctg gcctggcaat gaccgcctgc ttacccccaa cgagtttgaa 21060 attaagcgct cagttgacgg ggagggttac aacgttgccc agtgtaacat gaccaaagac 21120 tggttcctgg tacaaatgct agctaactac aacattggct accagggctt ctatatccca 21180 gagagctaca aggaccgcat gtactccttc tttagaaact tccagcccat gagccgtcag 21240 gtggtggatg atactaaata caaggactac caacaggtgg gcatcctaca ccaacacaac 21300 aactctggat ttgttggcta ccttgccccc accatgcgcg aaggacaggc ctaccctgct 21360 aacttcccct atccgcttat aggcaagacc gcagttgaca gcattaccca gaaaaagttt 21420 ctttgcgatc gcaccctttg gcgcatccca ttctccagta actttatgtc catgggcgca 21480 ctcacagacc tgggccaaaa ccttctctac gccaactccg cccacgcgct agacatgact 21540 tttgaggtgg atcccatgga cgagcccacc cttctttatg ttttgtttga agtctttgac 21600 gtggtccgtg tgcaccggcc gcaccgcggc gtcatcgaaa ccgtgtacct gcgcacgccc 21660 ttctcggccg gcaacgccac aacataaaga agcaagcaac atcaacaaca gctgccgcca 21720 tgggctccag tgagcaggaa ctgaaagcca ttgtcaaaga tcttggttgt gggccatatt 21780 ttttgggcac ctatgacaag cgctttccag gctttgtttc tccacacaag ctcgcctgcg 21840 ccatagtcaa tacggccggt cgcgagactg ggggcgtaca ctggatggcc tttgcctgga 21900 acccgcactc aaaaacatgc tacctctttg agccctttgg cttttctgac cagcgactca 21960 agcaggttta ccagtttgag tacgagtcac tcctgcgccg tagcgccatt gcttcttccc 22020 ccgaccgctg tataacgctg gaaaagtcca cccaaagcgt acaggggccc aactcggccg 22080 cctgtggact attctgctgc atgtttctcc acgcctttgc caactggccc caaactccca 22140 tggatcacaa ccccaccatg aaccttatta ccggggtacc caactccatg ctcaacagtc 22200 cccaggtaca gcccaccctg cgtcgcaacc aggaacagct ctacagcttc ctggagcgcc 22260 actcgcccta cttccgcagc cacagtgcgc agattaggag cgccacttct ttttgtcact 22320 tgaaaaacat gtaaaaataa tgtactagag acactttcaa taaaggcaaa tgcttttatt 22380 tgtacactct cgggtgatta tttaccccca cccttgccgt ctgcgccgtt taaaaatcaa 22440 aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga tactggtgtt 22500 tagtgctcca cttaaactca ggcacaacca tccgcggcag ctcggtgaag ttttcactcc 22560 acaggctgcg caccatcacc aacgcgttta gcaggtcggg cgccgatatc ttgaagtcgc 22620 agttggggcc tccgccctgc gcgcgcgagt tgcgatacac agggttgcag cactggaaca 22680 ctatcagcgc cgggtggtgc acgctggcca gcacgctctt gtcggagatc agatccgcgt 22740 ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt tggtagctgc cttcccaaaa 22800 agggcgcgtg cccaggcttt gagttgcact cgcaccgtag tggcatcaaa aggtgaccgt 22860 gcccggtctg ggcgttagga tacagcgcct gcataaaagc cttgatctgc ttaaaagcca 22920 cctgagcctt tgcgccttca gagaagaaca tgccgcaaga cttgccggaa aactgattgg 22980 ccggacaggc cgcgtcgtgc acgcagcacc ttgcgtcggt gttggagatc tgcaccacat 23040 ttcggcccca ccggttcttc acgatcttgg ccttgctaga ctgctccttc agcgcgcgct 23100 gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc cttatttatc ataatgcttc 23160 cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg gtgcagccac aacgcgcagc 23220 ccgtgggctc gtgatgcttg taggtcacct ctgcaaacga ctgcaggtac gcctgcagga 23280 atcgccccat catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc aacccgcggt 23340 gctcctcgtt cagccaggtc ttgcatacgg ccgccagagc ttccacttgg tcaggcagta 23400 gtttgaagtt cgcctttaga tcgttatcca cgtggtactt gtccatcagc gcgcgcgcag 23460 cctccatgcc cttctcccac gcagacacga tcggcacact cagcgggttc atcaccgtaa 23520 tttcactttc cgcttcgctg ggctcttcct cttcctcttg cgtccgcata ccacgcgcca 23580 ctgggtcgtc ttcattcagc cgccgcactg tgcgcttacc tcctttgcca tgcttgatta 23640 gcaccggtgg gttgctgaaa cccaccattt gtagcgccac atcttctctt tcttcctcgc 23700 tgtccacgat tacctctggt gatggcgggc gctcgggctt gggagaaggg cgcttctttt 23760 tcttcttggg cgcaatggcc aaatccgccg ccgaggtcga tggccgcggg ctgggtgtgc 23820 gcggcaccag cgcgtcttgt gatgagtctt cctcgtcctc ggactcgata cgccgcctca 23880 tccgcttttt tgggggcgcc cggggaggcg gcggcgacgg ggacggggac gacacgtcct 23940 ccatggttgg gggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt tcgcgctgct 24000 cctcttcccg actggccatt tccttctcct ataggcagaa aaagatcatg gagtcagtcg 24060 agaagaagga cagcctaacc gccccctctg agttcgccac caccgcctcc accgatgccg 24120 ccaacgcgcc taccaccttc cccgtcgagg cacccccgct tgaggaggag gaagtgatta 24180 tcgagcagga cccaggtttt gtaagcgaag acgacgagga ccgctcagta ccaacagagg 24240 ataaaaagca agaccaggac aacgcagagg caaacgagga acaagtcggg cggggggacg 24300 aaaggcatgg cgactaccta gatgtgggag acgacgtgct gttgaagcat ctgcagcgcc 24360 agtgcgccat tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc gccatagcgg 24420 atgtcagcct tgcctacgaa cgccacctat tctcaccgcg cgtacccccc aaacgccaag 24480 aaaacggcac atgcgagccc aacccgcgcc tcaacttcta ccccgtattt gccgtgccag 24540 aggtgcttgc cacctatcac atctttttcc aaaactgcaa gataccccta tcctgccgtg 24600 ccaaccgcag ccgagcggac aagcagctgg ccttgcggca gggcgctgtc atacctgata 24660 tcgcctcgct caacgaagtg ccaaaaatct ttgagggtct tggacgcgac gagaagcgcg 24720 cggcaaacgc tctgcaacag gaaaacagcg aaaatgaaag tcactctgga gtgttggtgg 24780 aactcgaggg tgacaacgcg cgcctagccg tactaaaacg cagcatcgag gtcacccact 24840 ttgcctaccc ggcacttaac ctacccccca aggtcatgag cacagtcatg agtgagctga 24900 tcgtgcgccg tgcgcagccc ctggagaggg atgcaaattt gcaagaacaa acagaggagg 24960 gcctacccgc agttggcgac gagcagctag cgcgctggct tcaaacgcgc gagcctgccg 25020 acttggagga gcgacgcaaa ctaatgatgg ccgcagtgct cgttaccgtg gagcttgagt 25080 gcatgcagcg gttctttgct gacccggaga tgcagcgcaa gctagaggaa acattgcact 25140 acacctttcg acagggctac gtacgccagg cctgcaagat ctccaacgtg gagctctgca 25200 acctggtctc ctaccttgga attttgcacg aaaaccgcct tgggcaaaac gtgcttcatt 25260 ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac ttatttctat 25320 gctacacctg gcagacggcc atgggcgttt ggcagcagtg cttggaggag tgcaacctca 25380 aggagctgca gaaactgcta aagcaaaact tgaaggacct atggacggcc ttcaacgagc 25440 gctccgtggc cgcgcacctg gcggacatca ttttccccga acgcctgctt aaaaccctgc 25500 aacagggtct gccagacttc accagtcaaa gcatgttgca gaactttagg aactttatcc 25560 tagagcgctc aggaatcttg cccgccacct gctgtgcact tcctagcgac tttgtgccca 25620 ttaagtaccg cgaatgccct ccgccgcttt ggggccactg ctaccttctg cagctagcca 25680 actaccttgc ctaccactct gacataatgg aagacgtgag cggtgacggt ctactggagt 25740 gtcactgtcg ctgcaaccta tgcaccccgc accgctccct ggtttgcaat tcgcagctgc 25800 ttaacgaaag tcaaattatc ggtacctttg agctgcaggg tccctcgcct gacgaaaagt 25860 ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac gtcggcttac cttcgcaaat 25920 ttgtacctga ggactaccac gcccacgaga ttaggttcta cgaagaccaa tcccgcccgc 25980 caaatgcgga gcttaccgcc tgcgtcatta cccagggcca cattcttggc caattgcaag 26040 ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg acggggggtt tacttggacc 26100 cccagtccgg cgaggagctc aacccaatcc ccccgccgcc gcagccctat cagcagcagc 26160 cgcgggccct tgcttcccag gatggcaccc aaaaagaagc tgcagctgcc gccgccaccc 26220 acggacgagg aggaatactg ggacagtcag gcagaggagg ttttggacga ggaggaggag 26280 gacatgatgg aagactggga gagcctagac gaggaagctt ccgaggtcga agaggtgtca 26340 gacgaaacac cgtcaccctc ggtcgcattc ccctcgccgg cgccccagaa atcggcaacc 26400 ggttccagca tggctacaac ctccgctcct caggcgccgc cggcactgcc cgttcgccga 26460 cccaaccgta gatgggacac cactggaacc agggccggta agtccaagca gccgccgccg 26520 ttagcccaag agcaacaaca gcgccaaggc taccgctcat ggcgcgggca caagaacgcc 26580 atagttgctt gcttgcaaga ctgtgggggc aacatctcct tcgcccgccg ctttcttctc 26640 taccatcacg gcgtggcctt cccccgtaac atcctgcatt actaccgtca tctctacagc 26700 ccatactgca ccggcggcag cggcagcggc agcaacagca gcggccacac agaagcaaag 26760 gcgaccggat agcaagactc tgacaaagcc caagaaatcc acagcggcgg cagcagcagg 26820 aggaggagcg ctgcgtctgg cgcccaacga acccgtatcg acccgcgagc ttagaaacag 26880 gatttttccc actctgtatg ctatatttca acagagcagg ggccaagaac aagagctgaa 26940 aataaaaaac aggtctctgc gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga 27000 tcagcttcgg cgcacgctgg aagacgcgga ggctctcttc agtaaatact gcgcgctgac 27060 tcttaaggac tagtttcgcg ccctttctca aatttaagcg cgaaaactac gtcatctcca 27120 gcggccacac ccggcgccag cacctgtcgt cagcgccatt tatgagcaag gaaattccca 27180 cgccctacat gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact 27240 actcaacccg aataaactac atgagcgcgg gaccccacat gatatcccgg gtcaacggaa 27300 tacgcgccca ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta 27360 ataaccttaa tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca 27420 ccactgtggt acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc 27480 agcttgcggg cggctttcgt cacagggtgc ggtcgcccgg gcagggtata actcacctga 27540 caatcagagg gcgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc 27600 gtccggacgg gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg 27660 caatcctaac tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactctgc 27720 aatttattga ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc 27780 actatccgga tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg 27840 actgaatgtt aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc 27900 gccacaagtg ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc 27960 atatcgaggg cccggcgcac ggcgtccggc ttaccgccca gggagagctt gcccgtagcc 28020 tgattcggga gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc 28080 tcactgtgat ttgcaactgt cctaaccctg gattacatca agatctttgt tgccatctct 28140 gtgctgagta taataaatac agaaattaaa atatactggg gctcctatcg ccatcctgta 28200 aacgccaccg tcttcacccg cccaagcaaa ccaaggcgaa ccttacctgg tacttttaac 28260 atctctccct ctgtgattta caacagtttc aacccagacg gagtgagtct acgagagaac 28320 ctctccgagc tcagctactc catcagaaaa aacaccaccc tccttacctg ccgggaacgt 28380 acgagtgcgt caccggccgc tgcaccacac ctaccgcctg accgtaaacc agactttttc 28440 cggacagacc tcaataactc tgtttaccag aacaggaggt gagcttagaa aacccttagg 28500 gtattaggcc aaaggcgcag ctactgtggg gtttatgaac aattcaagca actctacggg 28560 ctattctaat tcaggtttct ctagaatcgg ggttggggtt attctctgtc ttgtgattct 28620 ctttattctt atactaacgc ttctctgcct aaggctcgcc gcctgctgtg tgcacatttg 28680 catttattgt cagcttttta aacgctgggg tcgccaccca agatgattag gtacataatc 28740 ctaggtttac tcacccttgc gtcagcccac ggtaccaccc aaaaggtgga ttttaaggag 28800 ccagcctgta atgttacatt cgcagctgaa gctaatgagt gcaccactct tataaaatgc 28860 accacagaac atgaaaagct gcttattcgc cacaaaaaca aaattggcaa gtatgctgtt 28920 tatgctattt ggcagccagg tgacactaca gagtataatg ttacagtttt ccagggtaaa 28980 agtcataaaa cttttatgta tacttttcca ttttatgaaa tgtgcgacat taccatgtac 29040 atgagcaaac agtataagtt gtggccccca caaaattgtg tggaaaacac tggcactttc 29100 tgctgcactg ctatgctaat tacagtgctc gctttggtct gtaccctact ctatattaaa 29160 tacaaaagca gacgcagctt tattgaggaa aagaaaatgc cttaatttac taagttacaa 29220 agctaatgtc accactaact gctttactcg ctgcttgcaa aacaaattca aaaagttagc 29280 attataatta gaataggatt taaacccccc ggtcatttcc tgctcaatac cattcccctg 29340 aacaattgac tctatgtggg atatgctcca gcgctacaac cttgaagtca ggcttcctgg 29400 atgtcagcat ctgactttgg ccagcacctg tcccgcggat ttgttccagt ccaactacag 29460 cgacccaccc taacagagat gaccaacaca accaacgcgg ccgccgctac cggacttaca 29520 tctaccacaa atacacccca agtttctgcc tttgtcaata actgggataa cttgggcatg 29580 tggtggttct ccatagcgct tatgtttgta tgccttatta ttatgtggct catctgctgc 29640 ctaaagcgca aacgcgcccg accacccatc tatagtccca tcattgtgct acacccaaac 29700 aatgatggaa tccatagatt ggacggactg aaacacatgt tcttttctct tacagtatga 29760 ttaaatgaga catgattcct cgagttttta tattactgac ccttgttgcg cttttttgtg 29820 cgtgctccac attggctgcg gtttctcaca tcgaagtaga ctgcattcca gccttcacag 29880 tctatttgct ttacggattt gtcaccctca cgctcatctg cagcctcatc actgtggtca 29940 tcgcctttat ccagtgcatt gactgggtct gtgtgcgctt tgcatatctc agacaccatc 30000 cccagtacag ggacaggact atagctgagc ttcttagaat tctttaatta tgaaatttac 30060 tgtgactttt ctgctgatta tttgcaccct atctgcgttt tgttccccga cctccaagcc 30120 tcaaagacat atatcatgca gattcactcg tatatggaat attccaagtt gctacaatga 30180 aaaaagcgat ctttccgaag cctggttata tgcaatcatc tctgttatgg tgttctgcag 30240 taccatctta gccctagcta tatatcccta ccttgacatt ggctggaacg caatagatgc 30300 catgaaccac ccaactttcc ccgcgcccgc tatgcttcca ctgcaacaag ttgttgccgg 30360 cggctttgtc ccagccaatc agcctcgccc accttctccc acccccactg aaatcagcta 30420 ctttaatcta acaggaggag atgactgaca ccctagatct agaaatggac ggaattatta 30480 cagagcagcg cctgctagaa agacgcaggg cagcggccga gcaacagcgc atgaatcaag 30540 agctccaaga catggttaac ttgcaccagt gcaaaagggg tatcttttgt ctggtaaagc 30600 aggccaaagt cacctacgac agtaatacca ccggacaccg ccttagctac aagttgccaa 30660 ccaagcgtca gaaattggtg gtcatggtgg gagaaaagcc cattaccata actcagcact 30720 cggtagaaac cgaaggctgc attcactcac cttgtcaagg acctgaggat ctctgcaccc 30780 ttattaagac cctgtgcggt ctcaaagatc ttattccctt taactaataa aaaaaaataa 30840 taaagcatca cttacttaaa atcagttagc aaatttctgt ccagtttatt cagcagcacc 30900 tccttgccct cctcccagct ctggtattgc agcttcctcc tggctgcaaa ctttctccac 30960 aatctaaatg gaatgtcagt ttcctcctgt tcctgtccat ccgcacccac tatcttcatg 31020 ttgttgcaga tgaagcgcgc aagaccgtct gaagatacct tcaaccccgt gtatccatat 31080 gacacggaaa ccggtcctcc aactgtgcct tttcttactc ctccctttgt atcccccaat 31140 gggtttcaag agagtccccc tggggtactc tctttgcgcc tatccgaacc tctagttacc 31200 tccaatggca tgcttgcgct caaaatgggc aacggcctct ctctggacga ggccggcaac 31260 cttacctccc aaaatgtaac cactgtgagc ccacctctca aaaaaaccaa gtcaaacata 31320 aacctggaaa tatctgcacc cctcacagtt acctcagaag ccctaactgt ggctgccgcc 31380 gcacctctaa tggtcgcggg caacacactc accatgcaat cacaggcccc gctaaccgtg 31440 cacgactcca aacttagcat tgccacccaa ggacccctca cagtgtcaga aggaaagcta 31500 gccctgcaaa catcaggccc cctcaccacc accgatagca gtacccttac tatcactgcc 31560 tcaccccctc taactactgc cactggtagc ttgggcattg acttgaaaga gcccatttat 31620 acacaaaatg gaaaactagg actaaagtac ggggctcctt tgcatgtaac agacgaccta 31680 aacactttga ccgtagcaac tggtccaggt gtgactatta ataatacttc cttgcaaact 31740 aaagttactg gagccttggg ttttgattca caaggcaata tgcaacttaa tgtagcagga 31800 ggactaagga ttgattctca aaacagacgc cttatacttg atgttagtta tccgtttgat 31860 gctcaaaacc aactaaatct aagactagga cagggccctc tttttataaa ctcagcccac 31920 aacttggata ttaactacaa caaaggcctt tacttgttta cagcttcaaa caattccaaa 31980 aagcttgagg ttaacctaag cactgccaag gggttgatgt ttgacgctac agccatagcc 32040 attaatgcag gagatgggct tgaatttggt tcacctaatg caccaaacac aaatcccctc 32100 aaaacaaaaa ttggccatgg cctagaattt gattcaaaca aggctatggt tcctaaacta 32160 ggaactggcc ttagttttga cagcacaggt gccattacag taggaaacaa aaataatgat 32220 aagctaactt tgtggaccac accagctcca tctcctaact gtagactaaa tgcagagaaa 32280 gatgctaaac tcactttggt cttaacaaaa tgtggcagtc aaatacttgc tacagtttca 32340 gttttggctg ttaaaggcag tttggctcca atatctggaa cagttcaaag tgctcatctt 32400 attataagat ttgacgaaaa tggagtgcta ctaaacaatt ccttcctgga cccagaatat 32460 tggaacttta gaaatggaga tcttactgaa ggcacagcct atacaaacgc tgttggattt 32520 atgcctaacc tatcagctta tccaaaatct cacggtaaaa ctgccaaaag taacattgtc 32580 agtcaagttt acttaaacgg agacaaaact aaacctgtaa cactaaccat tacactaaac 32640 ggtacacagg aaacaggaga cacaactcca agtgcatact ctatgtcatt ttcatgggac 32700 tggtctggcc acaactacat taatgaaata tttgccacat cctcttacac tttttcatac 32760 attgcccaag aataaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca 32820 gaaaatttcg aatcattttt cattcagtag tatagcccca ccaccacata gcttatacag 32880 atcaccgtac cttaatcaaa cctacatggg ggtagagtca taatcgtgca tcaggatagg 32940 gcggtggtgc tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga 33000 atacaacatg gcagtggtct cctcagcgat gattcgcacc gcccgcagca taaggcgcct 33060 tgtcctccgg gcacagcagc gcaccctgat ctcacttaaa tcagcacagt aactgcagca 33120 cagcaccaca atattgttca aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc 33180 ggggaccaca gaacccacgt ggccatcata ccacaagcgc aggtagatta agtggcgacc 33240 cctcataaac acgctggaca taaacattac ctcttttggc atgttgtaat tcaccacctc 33300 ccggtaccat ataaacctct gattaaacat ggcgccatcc accaccatcc taaaccagct 33360 ggccaaaacc tgcccgccgg ctatacactg cagggaaccg ggactggaac aatgacagtg 33420 gagagcccag gactcgtaac catggatcat catgctcgtc atgatatcaa tgttggcaca 33480 acacaggcac acgtgcatac acttcctcag gattacaagc tcctcccgcg ttagaaccat 33540 atcccaggga acaacccatt cctgaatcag cgtaaatccc acactgcagg gaagacctcg 33600 cacgtaactc acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc 33660 cagtatggta gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac tgtacggagt 33720 gcgccgagac aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt 33780 agtcatattt cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg cgtctccggt 33840 ctcgccgctt agatcgctct gtgtagtagt tgtagtatat ccactctctc aaagcatcca 33900 ggcgccccct ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc ctgataacat 33960 ccaccaccgc agaataagcc acacccagcc aacctacaca ttcgttctgc gagtcacaca 34020 cgggaggagc gggaagagct ggaagaacca tgtttttttt tttattccaa aagattatcc 34080 aaaacctcaa aatgaagatc tattaagtga acgcgctccc ctccggtggc gtggtcaaac 34140 tctacagcca aagaacagat aatggcattt gtaagatgtt gcacaatggc ttccaaaagg 34200 caaacggccc tcacgtccaa gtggacgtaa aggctaaacc cttcagggtg aatctcctct 34260 ataaacattc cagcaccttc aaccatgccc aaataattct catctcgcca ccttctcaat 34320 atatctctaa gcaaatcccg aatattaagt ccggccattg taaaaatctg ctccagagcg 34380 ccctccacct tcagcctcaa gcagcgaatc atgattgcaa aaattcaggt tcctcacaga 34440 cctgtataag attcaaaagc ggaacattaa caaaaatacc gcgatcccgt aggtcccttc 34500 gcagggccag ctgaacataa tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc 34560 caggaaccat gacaaaagaa cccacactga ttatgacacg catactcgga gctatgctaa 34620 ccagcgtagc cccgatgtaa gcttgttgca tgggcggcga tataaaatgc aaggtgctgc 34680 tcaaaaaatc aggcaaagcc tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca 34740 gataaaggca ggtaagctcc ggaaccacca cagaaaaaga caccattttt ctctcaaaca 34800 taacagtcag ccttaccagt aaaaaagaaa acctattaaa aaaacaccac tcgacacggc 34860 accagctcaa tcagtcacag tgtaaaaaag ggccaagtgc agagcgagta tatataggac 34920 taaaaaatga cgtaacggtt aaagtccaca aaaaacaccc agaaaaccgc acgcgaacct 34980 acgcccagaa acgaaagcca aaaaacccac aacttcctca aatcgtcact tccgttttcc 35040 cacgttacgt cacttcccat tttaagaaaa ctacaattcc caacacatac aagttactcc 35100 gccctaaaac ctacgtcacc cgccccgttc ccacgccccg cgccacgtca caaactccac 35160 cccctcatta tcatattggc ttcaatccaa aataaggtat attattgatg atg 35213 <210> 9 <211> 35941 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO235) <400> 9 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttaccgg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcaagtca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaactcac agaaccctag tattcaacct 32940 gccacctccc tcccaacaca cagagtacac agtcctttct ccccggctgg ccttaaaaag 33000 catcatatca tgggtaacag acatattctt aggtgttata ttccacacgg tttcctgtcg 33060 agccaaacgc tcatcagtga tattaataaa ctccccgggc agctcactta agttcatgtc 33120 gctgtccagc tgctgagcca caggctgctg tccaacttgc ggttgcttaa cgggcggcga 33180 aggagaagtc cacgcctaca tgggggtaga gtcataatcg tgcatcagga tagggcggtg 33240 gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc tccgtcctgc aggaatacaa 33300 catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc gccttgtcct 33360 ccgggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc agcacagcac 33420 cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca tggcggggac 33480 cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc gacccctcat 33540 aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca cctcccggta 33600 ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc agctggccaa 33660 aacctgcccg ccggctatac actgcaggga accgggactg gaacaatgac agtggagagc 33720 ccaggactcg taaccatgga tcatcatgct cgtcatgata tcaatgttgg cacaacacag 33780 gcacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa ccatatccca 33840 gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac ctcgcacgta 33900 actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat cctccagtat 33960 ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg gagtgcgccg 34020 agacaaccga gatcgtgttg gtcgtagtgt catgccaaat ggaacgccgg acgtagtcat 34080 atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc cggtctcgcc 34140 gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca tccaggcgcc 34200 ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata acatccacca 34260 ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca cacacgggag 34320 gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt atccaaaacc 34380 tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc aaactctaca 34440 gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa aaggcaaacg 34500 gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc ctctataaac 34560 attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct caatatatct 34620 ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag agcgccctcc 34680 accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca cagacctgta 34740 taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc cttcgcaggg 34800 ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc ccgccaggaa 34860 ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg ctaaccagcg 34920 tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg ctgctcaaaa 34980 aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta gtcatgctca tgcagataaa 35040 ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca aacatgtctg 35100 cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat tagaagcctg 35160 tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca tgccggcgtg 35220 accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct cggtcatgtc 35280 cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg tcagtgctaa 35340 aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca acattacagc 35400 ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac ctgaaaaacc 35460 ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg cttccacagc 35520 ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa aacaccactc 35580 gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag agcgagtata 35640 tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag aaaaccgcac 35700 gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa tcgtcacttc 35760 cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca acacatacaa 35820 gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg ccacgtcaca 35880 aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat tattgatgat 35940 g 35941 <210> 10 <211> 35662 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO287) <400> 10 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttaccgg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcaagtca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaacctac atgggggtag agtcataatc 32940 gtgcatcagg atagggcggt ggtgctgcag cagcgcgcga ataaactgct gccgccgccg 33000 ctccgtcctg caggaataca acatggcagt ggtctcctca gcgatgattc gcaccgcccg 33060 cagcataagg cgccttgtcc tccgggcaca gcagcgcacc ctgatctcac ttaaatcagc 33120 acagtaactg cagcacagca ccacaatatt gttcaaaatc ccacagtgca aggcgctgta 33180 tccaaagctc atggcgggga ccacagaacc cacgtggcca tcataccaca agcgcaggta 33240 gattaagtgg cgacccctca taaacacgct ggacataaac attacctctt ttggcatgtt 33300 gtaattcacc acctcccggt accatataaa cctctgatta aacatggcgc catccaccac 33360 catcctaaac cagctggcca aaacctgccc gccggctata cactgcaggg aaccgggact 33420 ggaacaatga cagtggagag cccaggactc gtaaccatgg atcatcatgc tcgtcatgat 33480 atcaatgttg gcacaacaca ggcacacgtg catacacttc ctcaggatta caagctcctc 33540 ccgcgttaga accatatccc agggaacaac ccattcctga atcagcgtaa atcccacact 33600 gcagggaaga cctcgcacgt aactcacgtt gtgcattgtc aaagtgttac attcgggcag 33660 cagcggatga tcctccagta tggtagcgcg ggtttctgtc tcaaaaggag gtagacgatc 33720 cctactgtac ggagtgcgcc gagacaaccg agatcgtgtt ggtcgtagtg tcatgccaaa 33780 tggaacgccg gacgtagtca tatttcctga agcaaaacca ggtgcgggcg tgacaaacag 33840 atctgcgtct ccggtctcgc cgcttagatc gctctgtgta gtagttgtag tatatccact 33900 ctctcaaagc atccaggcgc cccctggctt cgggttctat gtaaactcct tcatgcgccg 33960 ctgccctgat aacatccacc accgcagaat aagccacacc cagccaacct acacattcgt 34020 tctgcgagtc acacacggga ggagcgggaa gagctggaag aaccatgttt ttttttttat 34080 tccaaaagat tatccaaaac ctcaaaatga agatctatta agtgaacgcg ctcccctccg 34140 gtggcgtggt caaactctac agccaaagaa cagataatgg catttgtaag atgttgcaca 34200 atggcttcca aaaggcaaac ggccctcacg tccaagtgga cgtaaaggct aaacccttca 34260 gggtgaatct cctctataaa cattccagca ccttcaacca tgcccaaata attctcatct 34320 cgccaccttc tcaatatatc tctaagcaaa tcccgaatat taagtccggc cattgtaaaa 34380 atctgctcca gagcgccctc caccttcagc ctcaagcagc gaatcatgat tgcaaaaatt 34440 caggttcctc acagacctgt ataagattca aaagcggaac attaacaaaa ataccgcgat 34500 cccgtaggtc ccttcgcagg gccagctgaa cataatcgtg caggtctgca cggaccagcg 34560 cggccacttc cccgccagga accatgacaa aagaacccac actgattatg acacgcatac 34620 tcggagctat gctaaccagc gtagccccga tgtaagcttg ttgcatgggc ggcgatataa 34680 aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg caaaaaagaa agcacatcgt 34740 agtcatgctc atgcagataa aggcaggtaa gctccggaac caccacagaa aaagacacca 34800 tttttctctc aaacatgtct gcgggtttct gcataaacac aaaataaaat aacaaaaaaa 34860 catttaaaca ttagaagcct gtcttacaac aggaaaaaca acccttataa gcataagacg 34920 gactacggcc atgccggcgt gaccgtaaaa aaactggtca ccgtgattaa aaagcaccac 34980 cgacagctcc tcggtcatgt ccggagtcat aatgtaagac tcggtaaaca catcaggttg 35040 attcacatcg gtcagtgcta aaaagcgacc gaaatagccc gggggaatac atacccgcag 35100 gcgtagagac aacattacag cccccatagg aggtataaca aaattaatag gagagaaaaa 35160 cacataaaca cctgaaaaac cctcctgcct aggcaaaata gcaccctccc gctccagaac 35220 aacatacagc gcttccacag cggcagccat aacagtcagc cttaccagta aaaaagaaaa 35280 cctattaaaa aaacaccact cgacacggca ccagctcaat cagtcacagt gtaaaaaagg 35340 gccaagtgca gagcgagtat atataggact aaaaaatgac gtaacggtta aagtccacaa 35400 aaaacaccca gaaaaccgca cgcgaaccta cgcccagaaa cgaaagccaa aaaacccaca 35460 acttcctcaa atcgtcactt ccgttttccc acgttacgtc acttcccatt ttaagaaaac 35520 tacaattccc aacacataca agttactccg ccctaaaacc tacgtcaccc gccccgttcc 35580 cacgccccgc gccacgtcac aaactccacc ccctcattat catattggct tcaatccaaa 35640 ataaggtata ttattgatga tg 35662 <210> 11 <211> 35653 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO288) <400> 11 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttaccgg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcgaatca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaacctac atgggggtag agtcataatc 32940 gtgcatcagg atagggcggt ggtgctgcag cagcgcgcga ataaactgct gccgccgccg 33000 ctccgtcctg caggaataca acatggcagt ggtctcctca gcgatgattc gcaccgcccg 33060 cagcataagg cgccttgtcc tccgggcaca gcagcgcacc ctgatctcac ttaaatcagc 33120 acagtaactg cagcacagca ccacaatatt gttcaaaatc ccacagtgca aggcgctgta 33180 tccaaagctc atggcgggga ccacagaacc cacgtggcca tcataccaca agcgcaggta 33240 gattaagtgg cgacccctca taaacacgct ggacataaac attacctctt ttggcatgtt 33300 gtaattcacc acctcccggt accatataaa cctctgatta aacatggcgc catccaccac 33360 catcctaaac cagctggcca aaacctgccc gccggctata cactgcaggg aaccgggact 33420 ggaacaatga cagtggagag cccaggactc gtaaccatgg atcatcatgc tcgtcatgat 33480 atcaatgttg gcacaacaca ggcacacgtg catacacttc ctcaggatta caagctcctc 33540 ccgcgttaga accatatccc agggaacaac ccattcctga atcagcgtaa atcccacact 33600 gcagggaaga cctcgcacgt aactcacgtt gtgcattgtc aaagtgttac attcgggcag 33660 cagcggatga tcctccagta tggtagcgcg ggtttctgtc tcaaaaggag gtagacgatc 33720 cctactgtac ggagtgcgcc gagacaaccg agatcgtgtt ggtcgtagtg tcatgccaaa 33780 tggaacgccg gacgtagtca tatttcctga agcaaaacca ggtgcgggcg tgacaaacag 33840 atctgcgtct ccggtctcgc cgcttagatc gctctgtgta gtagttgtag tatatccact 33900 ctctcaaagc atccaggcgc cccctggctt cgggttctat gtaaactcct tcatgcgccg 33960 ctgccctgat aacatccacc accgcagaat aagccacacc cagccaacct acacattcgt 34020 tctgcgagtc acacacggga ggagcgggaa gagctggaag aaccatgttt ttttttttat 34080 tccaaaagat tatccaaaac ctcaaaatga agatctatta agtgaacgcg ctcccctccg 34140 gtggcgtggt caaactctac agccaaagaa cagataatgg catttgtaag atgttgcaca 34200 atggcttcca aaaggcaaac ggccctcacg tccaagtgga cgtaaaggct aaacccttca 34260 gggtgaatct cctctataaa cattccagca ccttcaacca tgcccaaata attctcatct 34320 cgccaccttc tcaatatatc tctaagcaaa tcccgaatat taagtccggc cattgtaaaa 34380 atctgctcca gagcgccctc caccttcagc ctcaagcagc gaatcatgat tgcaaaaatt 34440 caggttcctc acagacctgt ataagattca aaagcggaac attaacaaaa ataccgcgat 34500 cccgtaggtc ccttcgcagg gccagctgaa cataatcgtg caggtctgca cggaccagcg 34560 cggccacttc cccgccagga accatgacaa aagaacccac actgattatg acacgcatac 34620 tcggagctat gctaaccagc gtagccccga tgtaagcttg ttgcatgggc ggcgatataa 34680 aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg caaaaaagaa agcacatcgt 34740 agtcatgctc atgcagataa aggcaggtaa gctccggaac caccacagaa aaagacacca 34800 tttttctctc aaacatgtct gcgggtttct gcataaacac aaaataaaat aacaaaaaaa 34860 catttaagcc tgtcttacaa caggaaaaac aacccttata agcataagac ggactacggc 34920 catgccggcg tgaccgtaaa aaaactggtc accgtgatta aaaagcacca ccgacagctc 34980 ctcggtcatg tccggagtca taatgtaaga ctcggtaaac acatcaggtt gattcacatc 35040 ggtcagtgct aaaaagcgac cgaaatagcc cgggggaata catacccgca ggcgtagaga 35100 caacattaca gcccccatag gaggtataac aaaattaata ggagagaaaa acacataaac 35160 acctgaaaaa ccctcctgcc taggcaaaat agcaccctcc cgctccagaa caacatacag 35220 cgcttccaca gcggcagcca taacagtcag ccttaccagt aaaaaagaaa acctattaaa 35280 aaaacaccac tcgacacggc accagctcaa tcagtcacag tgtaaaaaag ggccaagtgc 35340 agagcgagta tatataggac taaaaaatga cgtaacggtt aaagtccaca aaaaacaccc 35400 agaaaaccgc acgcgaacct acgcccagaa acgaaagcca aaaaacccac aacttcctca 35460 aatcgtcact tccgttttcc cacgttacgt cacttcccat tttaagaaaa ctacaattcc 35520 caacacatac aagttactcc gccctaaaac ctacgtcacc cgccccgttc ccacgccccg 35580 cgccacgtca caaactccac cccctcatta tcatattggc ttcaatccaa aataaggtat 35640 attattgatg atg 35653 <210> 12 <211> 35228 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO289) <400> 12 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttaccgg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcgaatca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaacctac atgggggtag agtcataatc 32940 gtgcatcagg atagggcggt ggtgctgcag cagcgcgcga ataaactgct gccgccgccg 33000 ctccgtcctg caggaataca acatggcagt ggtctcctca gcgatgattc gcaccgcccg 33060 cagcataagg cgccttgtcc tccgggcaca gcagcgcacc ctgatctcac ttaaatcagc 33120 acagtaactg cagcacagca ccacaatatt gttcaaaatc ccacagtgca aggcgctgta 33180 tccaaagctc atggcgggga ccacagaacc cacgtggcca tcataccaca agcgcaggta 33240 gattaagtgg cgacccctca taaacacgct ggacataaac attacctctt ttggcatgtt 33300 gtaattcacc acctcccggt accatataaa cctctgatta aacatggcgc catccaccac 33360 catcctaaac cagctggcca aaacctgccc gccggctata cactgcaggg aaccgggact 33420 ggaacaatga cagtggagag cccaggactc gtaaccatgg atcatcatgc tcgtcatgat 33480 atcaatgttg gcacaacaca ggcacacgtg catacacttc ctcaggatta caagctcctc 33540 ccgcgttaga accatatccc agggaacaac ccattcctga atcagcgtaa atcccacact 33600 gcagggaaga cctcgcacgt aactcacgtt gtgcattgtc aaagtgttac attcgggcag 33660 cagcggatga tcctccagta tggtagcgcg ggtttctgtc tcaaaaggag gtagacgatc 33720 cctactgtac ggagtgcgcc gagacaaccg agatcgtgtt ggtcgtagtg tcatgccaaa 33780 tggaacgccg gacgtagtca tatttcctga agcaaaacca ggtgcgggcg tgacaaacag 33840 atctgcgtct ccggtctcgc cgcttagatc gctctgtgta gtagttgtag tatatccact 33900 ctctcaaagc atccaggcgc cccctggctt cgggttctat gtaaactcct tcatgcgccg 33960 ctgccctgat aacatccacc accgcagaat aagccacacc cagccaacct acacattcgt 34020 tctgcgagtc acacacggga ggagcgggaa gagctggaag aaccatgttt ttttttttat 34080 tccaaaagat tatccaaaac ctcaaaatga agatctatta agtgaacgcg ctcccctccg 34140 gtggcgtggt caaactctac agccaaagaa cagataatgg catttgtaag atgttgcaca 34200 atggcttcca aaaggcaaac ggccctcacg tccaagtgga cgtaaaggct aaacccttca 34260 gggtgaatct cctctataaa cattccagca ccttcaacca tgcccaaata attctcatct 34320 cgccaccttc tcaatatatc tctaagcaaa tcccgaatat taagtccggc cattgtaaaa 34380 atctgctcca gagcgccctc caccttcagc ctcaagcagc gaatcatgat tgcaaaaatt 34440 caggttcctc acagacctgt ataagattca aaagcggaac attaacaaaa ataccgcgat 34500 cccgtaggtc ccttcgcagg gccagctgaa cataatcgtg caggtctgca cggaccagcg 34560 cggccacttc cccgccagga accatgacaa aagaacccac actgattatg acacgcatac 34620 tcggagctat gctaaccagc gtagccccga tgtaagcttg ttgcatgggc ggcgatataa 34680 aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg caaaaaagaa agcacatcgt 34740 agtcatgctc atgcagataa aggcaggtaa gctccggaac caccacagaa aaagacacca 34800 tttttctctc aaacataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac 34860 accactcgac acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc 34920 gagtatatat aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa 34980 accgcacgcg aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg 35040 tcacttccgt tttcccacgt tacgtcactt cccattttaa gaaaactaca attcccaaca 35100 catacaagtt actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca 35160 cgtcacaaac tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat 35220 tgatgatg 35228 <210> 13 <211> 35911 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO236) <400> 13 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgaccgaaga aatggccgcc agtcttttgg accagctgat 600 cgaagaggta ctggctgata atcttccacc tcctagccat tttgaaccac ctacccttca 660 cgaactgtat gatttagacg tgacggcccc cgaagatccc aacgaggagg cggtttcgca 720 gatttttccc gactctgtaa tgttggcggt gcaggaaggg attgacttac tcacttttcc 780 gccggcgccc ggttctccgg agccgcctca cctttcccgg cagcccgagc agccggagca 840 gagagccttg ggtccggttt ctatgccaaa ccttgtaccg gaggtgatcg atcttacctg 900 ccacgaggct ggctttccac ccagtgacga cgaggatgaa gagggtgagg agtttgtgtt 960 agattatgtg gagcaccccg ggcacggttg caggtcttgt cattatcacc ggaggaatac 1020 gggggaccca gatattatgt gttcgctttg ctatatgagg acctgtggca tgtttgtcta 1080 cagtaagtga aaattatggg cagtgggtga tagagtggtg ggtttggtgt ggtaattttt 1140 tttttaattt ttacagtttt gtggtttaaa gaattttgta ttgtgatttt tttaaaaggt 1200 cctgtgtctg aacctgagcc tgagcccgag ccagaaccgg agcctgcaag acctacccgc 1260 cgtcctaaaa tggcgcctgc tatcctgaga cgcccgacat cacctgtgtc tagagaatgc 1320 aatagtagta cggatagctg tgactccggt ccttctaaca cacctcctga gatacacccg 1380 gtggtcccgc tgtgccccat taaaccagtt gccgtgagag ttggtgggcg tcgccaggct 1440 gtggaatgta tcgaggactt gcttaacgag cctgggcaac ctttggactt gagctgtaaa 1500 cgccccaggc cataaggtgt aaacctgtga ttgcgtgtgt ggttaacgcc tttgtttgct 1560 gaatgagttg atgtaagttt aataaagggt gagataatgt ttaacttgca tggcgtgtta 1620 aatggggcgg ggcttaaagg gtatataatg cgccgtgggc taatcttggt tacatctgac 1680 ctcatggagg cttgggagtg tttggaagat ttttctgctg tgcgtaactt gctggaacag 1740 agctctaaca gtacctcttg gttttggagg tttctgtggg gctcatccca ggcaaagtta 1800 gtctgcagaa ttaaggagga ttacaagtgg gaatttgaag agcttttgaa atcctgtggt 1860 gagctgtttg attctttgaa tctgggtcac caggcgcttt tccaagagaa ggtcatcaag 1920 actttggatt tttccacacc ggggcgcgct gcggctgctg ttgctttttt gagttttata 1980 aaggataaat ggagcgaaga aacccatctg agcggggggt acctgctgga ttttctggcc 2040 atgcatctgt ggagagcggt tgtgagacac aagaatcgcc tgctactgtt gtcttccgtc 2100 cgcccggcga taataccgac ggaggagcag cagcagcagc aggaggaagc caggcggcgg 2160 cggcaggagc agagcccatg gaacccgaga gccggcctgg accctcggga atgaatgttg 2220 tacaggtggc tgaactgtat ccagaactga gacgcatttt gacaattaca gaggatgggc 2280 aggggctaaa gggggtaaag agggagcggg gggcttgtga ggctacagag gaggctagga 2340 atctagcttt tagcttaatg accagacacc gtcctgagtg tattactttt caacagatca 2400 aggataattg cgctaatgag cttgatctgc tggcgcagaa gtattccata gagcagctga 2460 ccacttactg gctgcagcca ggggatgatt ttgaggaggc tattagggta tatgcaaagg 2520 tggcacttag gccagattgc aagtacaaga tcagcaaact tgtaaatatc aggaattgtt 2580 gctacatttc tgggaacggg gccgaggtgg agatagatac ggaggatagg gtggccttta 2640 gatgtagcat gataaatatg tggccggggg tgcttggcat ggacggggtg gttattatga 2700 atgtaaggtt tactggcccc aattttagcg gtacggtttt cctggccaat accaacctta 2760 tcctacacgg tgtaagcttc tatgggttta acaatacctg tgtggaagcc tggaccgatg 2820 taagggttcg gggctgtgcc ttttactgct gctggaaggg ggtggtgtgt cgccccaaaa 2880 gcagggcttc aattaagaaa tgcctctttg aaaggtgtac cttgggtatc ctgtctgagg 2940 gtaactccag ggtgcgccac aatgtggcct ccgactgtgg ttgcttcatg ctagtgaaaa 3000 gcgtggctgt gattaagcat aacatggtat gtggcaactg cgaggacagg gcctctcaga 3060 tgctgacctg ctcggacggc aactgtcacc tgctgaagac cattcacgta gccagccact 3120 ctcgcaaggc ctggccagtg tttgagcata acatactgac ccgctgttcc ttgcatttgg 3180 gtaacaggag gggggtgttc ctaccttacc aatgcaattt gagtcacact aagatattgc 3240 ttgagcccga gagcatgtcc aaggtgaacc tgaacggggt gtttgacatg accatgaaga 3300 tctggaaggt gctgaggtac gatgagaccc gcaccaggtg cagaccctgc gagtgtggcg 3360 gtaaacatat taggaaccag cctgtgatgc tggatgtgac cgaggagctg aggcccgatc 3420 acttggtgct ggcctgcacc cgcgctgagt ttggctctag cgatgaagat acagattgag 3480 gtactgaaat gtgtgggcgt ggcttaaggg tgggaaagaa tatataaggt gggggtctta 3540 tgtagttttg tatctgtttt gcagcagccg ccgccgccat gagcaccaac tcgtttgatg 3600 gaagcattgt gagctcatat ttgacaacgc gcatgccccc atgggccggg gtgcgtcaga 3660 atgtgatggg ctccagcatt gatggtcgcc ccgtcctgcc cgcaaactct actaccttga 3720 cctacgagac cgtgtctgga acgccgttgg agactgcagc ctccgccgcc gcttcagccg 3780 ctgcagccac cgcccgcggg attgtgactg actttgcttt cctgagcccg cttgcaagca 3840 gtgcagcttc ccgttcatcc gcccgcgatg acaagttgac ggctcttttg gcacaattgg 3900 attctttgac ccgggaactt aatgtcgttt ctcagcagct gttggatctg cgccagcagg 3960 tttctgccct gaaggcttcc tcccctccca atgcggttta aaacataaat aaaaaaccag 4020 actctgtttg gatttggatc aagcataagt gtcttgctgt ctttatttag gggttttgcg 4080 cgcgcggtag gcccgggacc agcggtctcg gtcgttgagg gtcctgtgta ttttttccag 4140 gacgtggtaa aggtgactct ggatgttcag atacatgggc ataagcccgt ctctggggtg 4200 gaggtagcac cactgcagag cttcatgctg cggggtggtg ttgtagatga tccagtcgta 4260 gcaggagcgc tgggcgtggt gcctaaaaat gtctttcagt agcaagctga ttgccagggg 4320 caggcccttg gtgtaagtgt ttacaaagcg gttaagctgg gatgggtgca tacgtgggga 4380 tatgagatgc atcttggact gtatttttag gttggctatg ttcccagcca tatccctccg 4440 gggattcatg ttgtgcagaa ccaccagcac agtgtatccg gtgcacttgg gaaatttgtc 4500 atgtagctta gaaggaaatg cgtggaagaa cttggagacg cccttgtgac ctccaagatt 4560 ttccatgcat tcgtccataa tgatggcaat gggcccacgg gcggcggcct gggcgaagat 4620 atttctggga tcactaacgt catagttgtg ttccaggatg agatcgtcat aggccatttt 4680 tacaaagcgc gggcggaggg tgccagactg cggtataatg gttccatccg gcccaggggc 4740 gtagttaccc tcacagattt gcatttccca cgctttgagt tcagatgggg ggatcatgtc 4800 tacctgcggg gcgatgaaga aaacggtttc cggggtaggg gagatcagct gggaagaaag 4860 caggttcctg agcagctgcg acttaccgca gccggtgggc ccgtaaatca cacctattac 4920 cgggtgcaac tggtagttaa gagagctgca gctgccgtca tccctgagca ggggggccac 4980 ttcgttaagc atgtccctga ctcgcatgtt ttccctgacc aaatccgcca gaaggcgctc 5040 gccgcccagc gatagcagtt cttgcaagga agcaaagttt ttcaacggtt tgagaccgtc 5100 cgccgtaggc atgcttttga gcgtttgacc aagcagttcc aggcggtccc acagctcggt 5160 cacctgctct acggcatctc gatccagcat atctcctcgt ttcgcgggtt ggggcggctt 5220 tcgctgtacg gcagtagtcg gtgctcgtcc agacgggcca gggtcatgtc tttccacggg 5280 cgcagggtcc tcgtcagcgt agtctgggtc acggtgaagg ggtgcgctcc gggctgcgcg 5340 ctggccaggg tgcgcttgag gctggtcctg ctggtgctga agcgctgccg gtcttcgccc 5400 tgcgcgtcgg ccaggtagca tttgaccatg gtgtcatagt ccagcccctc cgcggcgtgg 5460 cccttggcgc gcagcttgcc cttggaggag gcgccgcacg aggggcagtg cagacttttg 5520 agggcgtaga gcttgggcgc gagaaatacc gattccgggg agtaggcatc cgcgccgcag 5580 gccccgcaga cggtctcgca ttccacgagc caggtgagct ctggccgttc ggggtcaaaa 5640 accaggtttc ccccatgctt tttgatgcgt ttcttacctc tggtttccat gagccggtgt 5700 ccacgctcgg tgacgaaaag gctgtccgtg tccccgtata cagacttgag aggcctgtcc 5760 tcgagcggtg ttccgcggtc ctcctcgtat agaaactcgg accactctga gacaaaggct 5820 cgcgtccagg ccagcacgaa ggaggctaag tgggaggggt agcggtcgtt gtccactagg 5880 gggtccactc gctccagggt gtgaagacac atgtcgccct cttcggcatc aaggaaggtg 5940 attggtttgt aggtgtaggc cacgtgaccg ggtgttcctg aaggggggct ataaaagggg 6000 gtgggggcgc gttcgtcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg 6060 ggtgagtact ccctctgaaa agcgggcatg acttctgcgc taagattgtc agtttccaaa 6120 aacgaggagg atttgatatt cacctggccc gcggtgatgc ctttgagggt ggccgcatcc 6180 atctggtcag aaaagacaat ctttttgttg tcaagcttgg tggcaaacga cccgtagagg 6240 gcgttggaca gcaacttggc gatggagcgc agggtttggt ttttgtcgcg atcggcgcgc 6300 tccttggccg cgatgtttag ctgcacgtat tcgcgcgcaa cgcaccgcca ttcgggaaag 6360 acggtggtgc gctcgtcggg caccaggtgc acgcgccaac cgcggttgtg cagggtgaca 6420 aggtcaacgc tggtggctac ctctccgcgt aggcgctcgt tggtccagca gaggcggccg 6480 cccttgcgcg agcagaatgg cggtaggggg tctagctgcg tctcgtccgg ggggtctgcg 6540 tccacggtaa agaccccggg cagcaggcgc gcgtcgaagt agtctatctt gcatccttgc 6600 aagtctagcg cctgctgcca tgcgcgggcg gcaagcgcgc gctcgtatgg gttgagtggg 6660 ggaccccatg gcatggggtg ggtgagcgcg gaggcgtaca tgccgcaaat gtcgtaaacg 6720 tagaggggct ctctgagtat tccaagatat gtagggtagc atcttccacc gcggatgctg 6780 gcgcgcacgt aatcgtatag ttcgtgcgag ggagcgagga ggtcgggacc gaggttgcta 6840 cgggcgggct gctctgctcg gaagactatc tgcctgaaga tggcatgtga gttggatgat 6900 atggttggac gctggaagac gttgaagctg gcgtctgtga gacctaccgc gtcacgcacg 6960 aaggaggcgt aggagtcgcg cagcttgttg accagctcgg cggtgacctg cacgtctagg 7020 gcgcagtagt ccagggtttc cttgatgatg tcatacttat cctgtccctt ttttttccac 7080 agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt actcttggat cggaaacccg 7140 tcggcctccg aacggtaaga gcctagcatg tagaactggt tgacggcctg gtaggcgcag 7200 catccctttt ctacgggtag cgcgtatgcc tgcgcggcct tccggagcga ggtgtgggtg 7260 agcgcaaagg tgtccctgac catgactttg aggtactggt atttgaagtc agtgtcgtcg 7320 catccgccct gctcccagag caaaaagtcc gtgcgctttt tggaacgcgg atttggcagg 7380 gcgaaggtga catcgttgaa gagtatcttt cccgcgcgag gcataaagtt gcgtgtgatg 7440 cggaagggtc ccggcacctc ggaacggttg ttaattacct gggcggcgag cacgatctcg 7500 tcaaagccgt tgatgttgtg gcccacaatg taaagttcca agaagcgcgg gatgcccttg 7560 atggaaggca attttttaag ttcctcgtag gtgagctctt caggggagct gagcccgtgc 7620 tctgaaaggg cccagtctgc aagatgaggg ttggaagcga cgaatgagct ccacaggtca 7680 cgggccatta gcatttgcag gtggtcgcga aaggtcctaa actggcgacc tatggccatt 7740 ttttctgggg tgatgcagta gaaggtaagc gggtcttgtt cccagcggtc ccatccaagg 7800 ttcgcggcta ggtctcgcgc ggcagtcact agaggctcat ctccgccgaa cttcatgacc 7860 agcatgaagg gcacgagctg cttcccaaag gcccccatcc aagtataggt ctctacatcg 7920 taggtgacaa agagacgctc ggtgcgagga tgcgagccga tcgggaagaa ctggatctcc 7980 cgccaccaat tggaggagtg gctattgatg tggtgaaagt agaagtccct gcgacgggcc 8040 gaacactcgt gctggctttt gtaaaaacgt gcgcagtact ggcagcggtg cacgggctgt 8100 acatcctgca cgaggttgac ctgacgaccg cgcacaagga agcagagtgg gaatttgagc 8160 ccctcgcctg gcgggtttgg ctggtggtct tctacttcgg ctgcttgtcc ttgaccgtct 8220 ggctgctcga ggggagttac ggtggatcgg accaccacgc cgcgcgagcc caaagtccag 8280 atgtccgcgc gcggcggtcg gagcttgatg acaacatcgc gcagatggga gctgtccatg 8340 gtctggagct cccgcggcgt caggtcaggc gggagctcct gcaggtttac ctcgcataga 8400 cgggtcaggg cgcgggctag atccaggtga tacctaattt ccaggggctg gttggtggcg 8460 gcgtcgatgg cttgcaagag gccgcatccc cgcggcgcga ctacggtacc gcgcggcggg 8520 cggtgggccg cgggggtgtc cttggatgat gcatctaaaa gcggtgacgc gggcgagccc 8580 ccggaggtag ggggggctcc ggacccgccg ggagaggggg caggggcacg tcggcgccgc 8640 gcgcgggcag gagctggtgc tgcgcgcgta ggttgctggc gaacgcgacg acgcggcggt 8700 tgatctcctg aatctggcgc ctctgcgtga agacgacggg cccggtgagc ttgagcctga 8760 aagagagttc gacagaatca atttcggtgt cgttgacggc ggcctggcgc aaaatctcct 8820 gcacgtctcc tgagttgtct tgataggcga tctcggccat gaactgctcg atctcttcct 8880 cctggagatc tccgcgtccg gctcgctcca cggtggcggc gaggtcgttg gaaatgcggg 8940 ccatgagctg cgagaaggcg ttgaggcctc cctcgttcca gacgcggctg tagaccacgc 9000 ccccttcggc atcgcgggcg cgcatgacca cctgcgcgag attgagctcc acgtgccggg 9060 cgaagacggc gtagtttcgc aggcgctgaa agaggtagtt gagggtggtg gcggtgtgtt 9120 ctgccacgaa gaagtacata acccagcgtc gcaacgtgga ttcgttgata tcccccaagg 9180 cctcaaggcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc 9240 gcgccgacac ggttaactcc tcctccagaa gacggatgag ctcggcgaca gtgtcgcgca 9300 cctcgcgctc aaaggctaca ggggcctctt cttcttcttc aatctcctct tccataaggg 9360 cctccccttc ttcttcttct ggcggcggtg ggggaggggg gacacggcgg cgacgacggc 9420 gcaccgggag gcggtcgaca aagcgctcga tcatctcccc gcggcgacgg cgcatggtct 9480 cggtgacggc gcggccgttc tcgcgggggc gcagttggaa gacgccgccc gtcatgtccc 9540 ggttatgggt tggcgggggg ctgccatgcg gcagggatac ggcgctaacg atgcatctca 9600 acaattgttg tgtaggtact ccgccgccga gggacctgag cgagtccgca tcgaccggat 9660 cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc gcaaggtagg ctgagcaccg 9720 tggcgggcgg cagcgggcgg cggtcggggt tgtttctggc ggaggtgctg ctgatgatgt 9780 aattaaagta ggcggtcttg agacggcgga tggtcgacag aagcaccatg tccttgggtc 9840 cggcctgctg aatgcgcagg cggtcggcca tgccccaggc ttcgttttga catcggcgca 9900 ggtctttgta gtagtcttgc atgagccttt ctaccggcac ttcttcttct ccttcctctt 9960 gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga gtttggccgt aggtggcgcc 10020 ctcttcctcc catgcgtgtg accccgaagc ccctcatcgg ctgaagcagg gctaggtcgg 10080 cgacaacgcg ctcggctaat atggcctgct gcacctgcgt gagggtagac tggaagtcat 10140 ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt gtaagtgcag ttggccataa 10200 cggaccagtt aacggtctgg tgacccggct gcgagagctc ggtgtacctg agacgcgagt 10260 aagccctcga gtcaaatacg tagtcgttgc aagtccgcac caggtactgg tatcccacca 10320 aaaagtgcgg cggcggctgg cggtagaggg gccagcgtag ggtggccggg gctccggggg 10380 cgagatcttc caacataagg cgatgatatc cgtagatgta cctggacatc caggtgatgc 10440 cggcggcggt ggtggaggcg cgcggaaagt cgcggacgcg gttccagatg ttgcgcagcg 10500 gcaaaaagtg ctccatggtc gggacgctct ggccggtcag gcgcgcgcaa tcgttgacgc 10560 tctagaccgt gcaaaaggag agcctgtaag cgggcactct tccgtggtct ggtggataaa 10620 ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc cgtatccggc cgtccgccgt 10680 gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga caacggggga 10740 gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc gctagctttt ttggccactg 10800 gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc tcgctccctg 10860 tagccggagg gttattttcc aagggttgag tcgcgggacc cccggttcga gtctcggacc 10920 ggccggactg cggcgaacgg gggtttgcct ccccgtcatg caagaccccg cttgcaaatt 10980 cctccggaaa cagggacgag cccctttttt gcttttccca gatgcatccg gtgctgcggc 11040 agatgcgccc ccctcctcag cagcggcaag agcaagagca gcggcagaca tgcagggcac 11100 cctcccctcc tcctaccgcg tcaggagggg cgacatccgc ggttgacgcg gcagcagatg 11160 gtgattacga acccccgcgg cgccgggccc ggcactacct ggacttggag gagggcgagg 11220 gcctggcgcg gctaggagcg ccctctcctg agcggtaccc aagggtgcag ctgaagcgtg 11280 atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg cgaccgcgag ggagaggagc 11340 ccgaggagat gcgggatcga aagttccacg cagggcgcga gctgcggcat ggcctgaatc 11400 gcgagcggtt gctgcgcgag gaggactttg agcccgacgc gcgaaccggg attagtcccg 11460 cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata cgagcagacg gtgaaccagg 11520 agattaactt tcaaaaaagc tttaacaacc acgtgcgtac gcttgtggcg cgcgaggagg 11580 tggctatagg actgatgcat ctgtgggact ttgtaagcgc gctggagcaa aacccaaata 11640 gcaagccgct catggcgcag ctgttcctta tagtgcagca cagcagggac aacgaggcat 11700 tcagggatgc gctgctaaac atagtagagc ccgagggccg ctggctgctc gatttgataa 11760 acatcctgca gagcatagtg gtgcaggagc gcagcttgag cctggctgac aaggtggccg 11820 ccatcaacta ttccatgctt agcctgggca agttttacgc ccgcaagata taccataccc 11880 cttacgttcc catagacaag gaggtaaaga tcgaggggtt ctacatgcgc atggcgctga 11940 aggtgcttac cttgagcgac gacctgggcg tttatcgcaa cgagcgcatc cacaaggccg 12000 tgagcgtgag ccggcggcgc gagctcagcg accgcgagct gatgcacagc ctgcaaaggg 12060 ccctggctgg cacgggcagc ggcgatagag aggccgagtc ctactttgac gcgggcgctg 12120 acctgcgctg ggccccaagc cgacgcgccc tggaggcagc tggggccgga cctgggctgg 12180 cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga ggaatatgac gaggacgatg 12240 agtacgagcc agaggacggc gagtactaag cggtgatgtt tctgatcaga tgatgcaaga 12300 cgcaacggac ccggcggtgc gggcggcgct gcagagccag ccgtccggcc ttaactccac 12360 ggacgactgg cgccaggtca tggaccgcat catgtcgctg actgcgcgca atcctgacgc 12420 gttccggcag cagccgcagg ccaaccggct ctccgcaatt ctggaagcgg tggtcccggc 12480 gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta aacgcgctgg ccgaaaacag 12540 ggccatccgg cccgacgagg ccggcctggt ctacgacgcg ctgcttcagc gcgtggctcg 12600 ttacaacagc ggcaacgtgc agaccaacct ggaccggctg gtgggggatg tgcgcgaggc 12660 cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg ggctccatgg ttgcactaaa 12720 cgccttcctg agtacacagc ccgccaacgt gccgcgggga caggaggact acaccaactt 12780 tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa agtgaggtgt accagtctgg 12840 gccagactat tttttccaga ccagtagaca aggcctgcag accgtaaacc tgagccaggc 12900 tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc acaggcgacc gcgcgaccgt 12960 gtctagcttg ctgacgccca actcgcgcct gttgctgctg ctaatagcgc ccttcacgga 13020 cagtggcagc gtgtcccggg acacatacct aggtcacttg ctgacactgt accgcgaggc 13080 cataggtcag gcgcatgtgg acgagcatac tttccaggag attacaagtg tcagccgcgc 13140 gctggggcag gaggacacgg gcagcctgga ggcaacccta aactacctgc tgaccaaccg 13200 gcggcagaag atcccctcgt tgcacagttt aaacagcgag gaggagcgca ttttgcgcta 13260 cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg gtaacgccca gcgtggcgct 13320 ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc tcaaaccggc cgtttatcaa 13380 ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac cccgagtatt tcaccaatgc 13440 catcttgaac ccgcactggc taccgccccc tggtttctac accgggggat tcgaggtgcc 13500 cgagggtaac gatggattcc tctgggacga catagacgac agcgtgtttt ccccgcaacc 13560 gcagaccctg ctagagttgc aacagcgcga gcaggcagag gcggcgctgc gaaaggaaag 13620 cttccgcagg ccaagcagct tgtccgatct aggcgctgcg gccccgcggt cagatgctag 13680 tagcccattt ccaagcttga tagggtctct taccagcact cgcaccaccc gcccgcgcct 13740 gctgggcgag gaggagtacc taaacaactc gctgctgcag ccgcagcgcg aaaaaaacct 13800 gcctccggca tttcccaaca acgggataga gagcctagtg gacaagatga gtagatggaa 13860 gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc ccgcccaccc gtcgtcaaag 13920 gcacgaccgt cagcggggtc tggtgtggga ggacgatgac tcggcagacg acagcagcgt 13980 cctggatttg ggagggagtg gcaacccgtt tgcgcacctt cgccccaggc tggggagaat 14040 gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc accaaggcca tggcaccgag 14100 cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg cgatgtatga ggaaggtcct 14160 cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg cggcggcgct gggttctccc 14220 ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt acctgcggcc taccgggggg 14280 agaaacagca tccgttactc tgagttggca cccctattcg acaccacccg tgtgtacctg 14340 gtggacaaca agtcaacgga tgtggcatcc ctgaactacc agaacgacca cagcaacttt 14400 ctgaccacgg tcattcaaaa caatgactac agcccggggg aggcaagcac acagaccatc 14460 aatcttgacg accggtcgca ctggggcggc gacctgaaaa ccatcctgca taccaacatg 14520 ccaaatgtga acgagttcat gtttaccaat aagtttaagg cgcgggtgat ggtgtcgcgc 14580 ttgcctacta aggacaatca ggtggagctg aaatacgagt gggtggagtt cacgctgccc 14640 gagggcaact actccgagac catgaccata gaccttatga acaacgcgat cgtggagcac 14700 tacttgaaag tgggcagaca gaacggggtt ctggaaagcg acatcggggt aaagtttgac 14760 acccgcaact tcagactggg gtttgacccc gtcactggtc ttgtcatgcc tggggtatat 14820 acaaacgaag ccttccatcc agacatcatt ttgctgccag gatgcggggt ggacttcacc 14880 cacagccgcc tgagcaactt gttgggcatc cgcaagcggc aacccttcca ggagggcttt 14940 aggatcacct acgatgatct ggagggtggt aacattcccg cactgttgga tgtggacgcc 15000 taccaggcga gcttgaaaga tgacaccgaa cagggcgggg gtggcgcagg cggcagcaac 15060 agcagtggca gcggcgcgga agagaactcc aacgcggcag ccgcggcaat gcagccggtg 15120 gaggacatga acgatcatgc cattcgcggc gacacctttg ccacacgggc tgaggagaag 15180 cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg ctgcgcaacc cgaggtcgag 15240 aagcctcaga agaaaccggt gatcaaaccc ctgacagagg acagcaagaa acgcagttac 15300 aacctaataa gcaatgacag caccttcacc cagtaccgca gctggtacct tgcatacaac 15360 tacggcgacc ctcagaccgg aatccgctca tggaccctgc tttgcactcc tgacgtaacc 15420 tgcggctcgg agcaggtcta ctggtcgttg ccagacatga tgcaagaccc cgtgaccttc 15480 cgctccacgc gccagatcag caactttccg gtggtgggcg ccgagctgtt gcccgtgcac 15540 tccaagagct tctacaacga ccaggccgtc tactcccaac tcatccgcca gtttacctct 15600 ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc gccagccccc 15660 accatcacca ccgtcagtga aaacgttcct gctctcacag atcacgggac gctaccgctg 15720 cgcaacagca tcggaggagt ccagcgagtg accattactg acgccagacg ccgcacctgc 15780 ccctacgttt acaaggccct gggcatagtc tcgccgcgcg tcctatcgag ccgcactttt 15840 tgagcaagca tgtccatcct tatatcgccc agcaataaca caggctgggg cctgcgcttc 15900 ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc aacacccagt gcgcgtgcgc 15960 gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc gcactgggcg caccaccgtc 16020 gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact acacgcccac gccgccacca 16080 gtgtccacag tggacgcggc cattcagacc gtggtgcgcg gagcccggcg ctatgctaaa 16140 atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc gccgacccgg cactgccgcc 16200 caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca ccggccgacg ggcggccatg 16260 cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc cccccaggtc caggcgacga 16320 gcggccgccg cagcagccgc ggccattagt gctatgactc agggtcgcag gggcaacgtg 16380 tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg tgcgcacccg ccccccgcgc 16440 aactagattg caagaaaaaa ctacttagac tcgtactgtt gtatgtatcc agcggcggcg 16500 gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag agatgctcca ggtcatcgcg 16560 ccggagatct atggcccccc gaagaaggaa gagcaggatt acaagccccg aaagctaaag 16620 cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg acgacgaggt ggaactgctg 16680 cacgctaccg cgcccaggcg acgggtacag tggaaaggtc gacgcgtaaa acgtgttttg 16740 cgacccggca ccaccgtagt ctttacgccc ggtgagcgct ccacccgcac ctacaagcgc 16800 gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc aggccaacga gcgcctcggg 16860 gagtttgcct acggaaagcg gcataaggac atgctggcgt tgccgctgga cgagggcaac 16920 ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc tgcccgcgct tgcaccgtcc 16980 gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg cacccaccgt gcagctgatg 17040 gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa tgaccgtgga acctgggctg 17100 gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc cgggactggg cgtgcagacc 17160 gtggacgttc agatacccac taccagtagc accagtattg ccaccgccac agagggcatg 17220 gagacacaaa cgtccccggt tgcctcagcg gtggcggatg ccgcggtgca ggcggtcgct 17280 gcggccgcgt ccaagacctc tacggaggtg caaacggacc cgtggatgtt tcgcgtttca 17340 gccccccggc gcccgcgcgg ttcgaggaag tacggcgccg ccagcgcgct actgcccgaa 17400 tatgccctac atccttccat tgcgcctacc cccggctatc gtggctacac ctaccgcccc 17460 agaagacgag caactacccg acgccgaacc accactggaa cccgccgccg ccgtcgccgt 17520 cgccagcccg tgctggcccc gatttccgtg cgcagggtgg ctcgcgaagg aggcaggacc 17580 ctggtgctgc caacagcgcg ctaccacccc agcatcgttt aaaagccggt ctttgtggtt 17640 cttgcagata tggccctcac ctgccgcctc cgtttcccgg tgccgggatt ccgaggaaga 17700 atgcaccgta ggaggggcat ggccggccac ggcctgacgg gcggcatgcg tcgtgcgcac 17760 caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg gtatcctgcc cctccttatt 17820 ccactgatcg ccgcggcgat tggcgccgtg cccggaattg catccgtggc cttgcaggcg 17880 cagagacact gattaaaaac aagttgcatg tggaaaaatc aaaataaaaa gtctggactc 17940 tcacgctcgc ttggtcctgt aactattttg tagaatggaa gacatcaact ttgcgtctct 18000 ggccccgcga cacggctcgc gcccgttcat gggaaactgg caagatatcg gcaccagcaa 18060 tatgagcggt ggcgccttca gctggggctc gctgtggagc ggcattaaaa atttcggttc 18120 caccgttaag aactatggca gcaaggcctg gaacagcagc acaggccaga tgctgaggga 18180 taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat ggcctggcct ctggcattag 18240 cggggtggtg gacctggcca accaggcagt gcaaaataag attaacagta agcttgatcc 18300 ccgccctccc gtagaggagc ctccaccggc cgtggagaca gtgtctccag aggggcgtgg 18360 cgaaaagcgt ccgcgccccg acagggaaga aactctggtg acgcaaatag acgagcctcc 18420 ctcgtacgag gaggcactaa agcaaggcct gcccaccacc cgtcccatcg cgcccatggc 18480 taccggagtg ctgggccagc acacacccgt aacgctggac ctgcctcccc ccgccgacac 18540 ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt gtaacccgtc ctagccgcgc 18600 gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg cccgtagcca gtggcaactg 18660 gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa tccctgaagc gccgacgatg 18720 cttctgaata gctaacgtgt cgtatgtgtg tcatgtatgc gtccatgtcg ccgccagagg 18780 agctgctgag ccgccgcgcg cccgctttcc aagatggcta ccccttcgat gatgccgcag 18840 tggtcttaca tgcacatctc gggccaggac gcctcggagt acctgagccc cgggctggtg 18900 cagtttgccc gcgccaccga gacgtacttc agcctgaata acaagtttag aaaccccacg 18960 gtggcgccta cgcacgacgt gaccacagac cggtcccagc gtttgacgct gcggttcatc 19020 cctgtggacc gtgaggatac tgcgtactcg tacaaggcgc ggttcaccct agctgtgggt 19080 gataaccgtg tgctggacat ggcttccacg tactttgaca tccgcggcgt gctggacagg 19140 ggccctactt ttaagcccta ctctggcact gcctacaacg ccctggctcc caagggtgcc 19200 ccaaatcctt gcgaatggga tgaagctgct actgctcttg aaataaacct agaagaagag 19260 gacgatgaca acgaagacga agtagacgag caagctgagc agcaaaaaac tcacgtattt 19320 gggcaggcgc cttattctgg tataaatatt acaaaggagg gtattcaaat aggtgtcgaa 19380 ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg aacctcaaat aggagaatct 19440 cagtggtacg aaactgaaat taatcatgca gctgggagag tccttaaaaa gactacccca 19500 atgaaaccat gttacggttc atatgcaaaa cccacaaatg aaaatggagg gcaaggcatt 19560 cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg aaatgcaatt tttctcaact 19620 actgaggcga ccgcaggcaa tggtgataac ttgactccta aagtggtatt gtacagtgaa 19680 gatgtagata tagaaacccc agacactcat atttcttaca tgcccactat taaggaaggt 19740 aactcacgag aactaatggg ccaacaatct atgcccaaca ggcctaatta cattgctttt 19800 agggacaatt ttattggtct aatgtattac aacagcacgg gtaatatggg tgttctggcg 19860 ggccaagcat cgcagttgaa tgctgttgta gatttgcaag acagaaacac agagctttca 19920 taccagcttt tgcttgattc cattggtgat agaaccaggt acttttctat gtggaatcag 19980 gctgttgaca gctatgatcc agatgttaga attattgaaa atcatggaac tgaagatgaa 20040 cttccaaatt actgctttcc actgggaggt gtgattaata cagagactct taccaaggta 20100 aaacctaaaa caggtcagga aaatggatgg gaaaaagatg ctacagaatt ttcagataaa 20160 aatgaaataa gagttggaaa taattttgcc atggaaatca atctaaatgc caacctgtgg 20220 agaaatttcc tgtactccaa catagcgctg tatttgcccg acaagctaaa gtacagtcct 20280 tccaacgtaa aaatttctga taacccaaac acctacgact acatgaacaa gcgagtggtg 20340 gctcccgggt tagtggactg ctacattaac cttggagcac gctggtccct tgactatatg 20400 gacaacgtca acccatttaa ccaccaccgc aatgctggcc tgcgctaccg ctcaatgttg 20460 ctgggcaatg gtcgctatgt gcccttccac atccaggtgc ctcagaagtt ctttgccatt 20520 aaaaacctcc ttctcctgcc gggctcatac acctacgagt ggaacttcag gaaggatgtt 20580 aacatggttc tgcagagctc cctaggaaat gacctaaggg ttgacggagc cagcattaag 20640 tttgatagca tttgccttta cgccaccttc ttccccatgg cccacaacac cgcctccacg 20700 cttgaggcca tgcttagaaa cgacaccaac gaccagtcct ttaacgacta tctctccgcc 20760 gccaacatgc tctaccctat acccgccaac gctaccaacg tgcccatatc catcccctcc 20820 cgcaactggg cggctttccg cggctgggcc ttcacgcgcc ttaagactaa ggaaacccca 20880 tcactgggct cgggctacga cccttattac acctactctg gctctatacc ctacctagat 20940 ggaacctttt acctcaacca cacctttaag aaggtggcca ttacctttga ctcttctgtc 21000 agctggcctg gcaatgaccg cctgcttacc cccaacgagt ttgaaattaa gcgctcagtt 21060 gacggggagg gttacaacgt tgcccagtgt aacatgacca aagactggtt cctggtacaa 21120 atgctagcta actacaacat tggctaccag ggcttctata tcccagagag ctacaaggac 21180 cgcatgtact ccttctttag aaacttccag cccatgagcc gtcaggtggt ggatgatact 21240 aaatacaagg actaccaaca ggtgggcatc ctacaccaac acaacaactc tggatttgtt 21300 ggctaccttg cccccaccat gcgcgaagga caggcctacc ctgctaactt cccctatccg 21360 cttataggca agaccgcagt tgacagcatt acccagaaaa agtttctttg cgatcgcacc 21420 ctttggcgca tcccattctc cagtaacttt atgtccatgg gcgcactcac agacctgggc 21480 caaaaccttc tctacgccaa ctccgcccac gcgctagaca tgacttttga ggtggatccc 21540 atggacgagc ccacccttct ttatgttttg tttgaagtct ttgacgtggt ccgtgtgcac 21600 cggccgcacc gcggcgtcat cgaaaccgtg tacctgcgca cgcccttctc ggccggcaac 21660 gccacaacat aaagaagcaa gcaacatcaa caacagctgc cgccatgggc tccagtgagc 21720 aggaactgaa agccattgtc aaagatcttg gttgtgggcc atattttttg ggcacctatg 21780 acaagcgctt tccaggcttt gtttctccac acaagctcgc ctgcgccata gtcaatacgg 21840 ccggtcgcga gactgggggc gtacactgga tggcctttgc ctggaacccg cactcaaaaa 21900 catgctacct ctttgagccc tttggctttt ctgaccagcg actcaagcag gtttaccagt 21960 ttgagtacga gtcactcctg cgccgtagcg ccattgcttc ttcccccgac cgctgtataa 22020 cgctggaaaa gtccacccaa agcgtacagg ggcccaactc ggccgcctgt ggactattct 22080 gctgcatgtt tctccacgcc tttgccaact ggccccaaac tcccatggat cacaacccca 22140 ccatgaacct tattaccggg gtacccaact ccatgctcaa cagtccccag gtacagccca 22200 ccctgcgtcg caaccaggaa cagctctaca gcttcctgga gcgccactcg ccctacttcc 22260 gcagccacag tgcgcagatt aggagcgcca cttctttttg tcacttgaaa aacatgtaaa 22320 aataatgtac tagagacact ttcaataaag gcaaatgctt ttatttgtac actctcgggt 22380 gattatttac ccccaccctt gccgtctgcg ccgtttaaaa atcaaagggg ttctgccgcg 22440 catcgctatg cgccactggc agggacacgt tgcgatactg gtgtttagtg ctccacttaa 22500 actcaggcac aaccatccgc ggcagctcgg tgaagttttc actccacagg ctgcgcacca 22560 tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa gtcgcagttg gggcctccgc 22620 cctgcgcgcg cgagttgcga tacacagggt tgcagcactg gaacactatc agcgccgggt 22680 ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc cgcgtccagg tcctccgcgt 22740 tgctcagggc gaacggagtc aactttggta gctgccttcc caaaaagggc gcgtgcccag 22800 gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg accgtgcccg gtctgggcgt 22860 taggatacag cgcctgcata aaagccttga tctgcttaaa agccacctga gcctttgcgc 22920 cttcagagaa gaacatgccg caagacttgc cggaaaactg attggccgga caggccgcgt 22980 cgtgcacgca gcaccttgcg tcggtgttgg agatctgcac cacatttcgg ccccaccggt 23040 tcttcacgat cttggccttg ctagactgct ccttcagcgc gcgctgcccg ttttcgctcg 23100 tcacatccat ttcaatcacg tgctccttat ttatcataat gcttccgtgt agacacttaa 23160 gctcgccttc gatctcagcg cagcggtgca gccacaacgc gcagcccgtg ggctcgtgat 23220 gcttgtaggt cacctctgca aacgactgca ggtacgcctg caggaatcgc cccatcatcg 23280 tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc gcggtgctcc tcgttcagcc 23340 aggtcttgca tacggccgcc agagcttcca cttggtcagg cagtagtttg aagttcgcct 23400 ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg cgcagcctcc atgcccttct 23460 cccacgcaga cacgatcggc acactcagcg ggttcatcac cgtaatttca ctttccgctt 23520 cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg cgccactggg tcgtcttcat 23580 tcagccgccg cactgtgcgc ttacctcctt tgccatgctt gattagcacc ggtgggttgc 23640 tgaaacccac catttgtagc gccacatctt ctctttcttc ctcgctgtcc acgattacct 23700 ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt ctttttcttc ttgggcgcaa 23760 tggccaaatc cgccgccgag gtcgatggcc gcgggctggg tgtgcgcggc accagcgcgt 23820 cttgtgatga gtcttcctcg tcctcggact cgatacgccg cctcatccgc ttttttgggg 23880 gcgcccgggg aggcggcggc gacggggacg gggacgacac gtcctccatg gttgggggac 23940 gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg ctgctcctct tcccgactgg 24000 ccatttcctt ctcctatagg cagaaaaaga tcatggagtc agtcgagaag aaggacagcc 24060 taaccgcccc ctctgagttc gccaccaccg cctccaccga tgccgccaac gcgcctacca 24120 ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt gattatcgag caggacccag 24180 gttttgtaag cgaagacgac gaggaccgct cagtaccaac agaggataaa aagcaagacc 24240 aggacaacgc agaggcaaac gaggaacaag tcgggcgggg ggacgaaagg catggcgact 24300 acctagatgt gggagacgac gtgctgttga agcatctgca gcgccagtgc gccattatct 24360 gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat agcggatgtc agccttgcct 24420 acgaacgcca cctattctca ccgcgcgtac cccccaaacg ccaagaaaac ggcacatgcg 24480 agcccaaccc gcgcctcaac ttctaccccg tatttgccgt gccagaggtg cttgccacct 24540 atcacatctt tttccaaaac tgcaagatac ccctatcctg ccgtgccaac cgcagccgag 24600 cggacaagca gctggccttg cggcagggcg ctgtcatacc tgatatcgcc tcgctcaacg 24660 aagtgccaaa aatctttgag ggtcttggac gcgacgagaa gcgcgcggca aacgctctgc 24720 aacaggaaaa cagcgaaaat gaaagtcact ctggagtgtt ggtggaactc gagggtgaca 24780 acgcgcgcct agccgtacta aaacgcagca tcgaggtcac ccactttgcc tacccggcac 24840 ttaacctacc ccccaaggtc atgagcacag tcatgagtga gctgatcgtg cgccgtgcgc 24900 agcccctgga gagggatgca aatttgcaag aacaaacaga ggagggccta cccgcagttg 24960 gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc tgccgacttg gaggagcgac 25020 gcaaactaat gatggccgca gtgctcgtta ccgtggagct tgagtgcatg cagcggttct 25080 ttgctgaccc ggagatgcag cgcaagctag aggaaacatt gcactacacc tttcgacagg 25140 gctacgtacg ccaggcctgc aagatctcca acgtggagct ctgcaacctg gtctcctacc 25200 ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct tcattccacg ctcaagggcg 25260 aggcgcgccg cgactacgtc cgcgactgcg tttacttatt tctatgctac acctggcaga 25320 cggccatggg cgtttggcag cagtgcttgg aggagtgcaa cctcaaggag ctgcagaaac 25380 tgctaaagca aaacttgaag gacctatgga cggccttcaa cgagcgctcc gtggccgcgc 25440 acctggcgga catcattttc cccgaacgcc tgcttaaaac cctgcaacag ggtctgccag 25500 acttcaccag tcaaagcatg ttgcagaact ttaggaactt tatcctagag cgctcaggaa 25560 tcttgcccgc cacctgctgt gcacttccta gcgactttgt gcccattaag taccgcgaat 25620 gccctccgcc gctttggggc cactgctacc ttctgcagct agccaactac cttgcctacc 25680 actctgacat aatggaagac gtgagcggtg acggtctact ggagtgtcac tgtcgctgca 25740 acctatgcac cccgcaccgc tccctggttt gcaattcgca gctgcttaac gaaagtcaaa 25800 ttatcggtac ctttgagctg cagggtccct cgcctgacga aaagtccgcg gctccggggt 25860 tgaaactcac tccggggctg tggacgtcgg cttaccttcg caaatttgta cctgaggact 25920 accacgccca cgagattagg ttctacgaag accaatcccg cccgccaaat gcggagctta 25980 ccgcctgcgt cattacccag ggccacattc ttggccaatt gcaagccatc aacaaagccc 26040 gccaagagtt tctgctacga aagggacggg gggtttactt ggacccccag tccggcgagg 26100 agctcaaccc aatccccccg ccgccgcagc cctatcagca gcagccgcgg gcccttgctt 26160 cccaggatgg cacccaaaaa gaagctgcag ctgccgccgc cacccacgga cgaggaggaa 26220 tactgggaca gtcaggcaga ggaggttttg gacgaggagg aggaggacat gatggaagac 26280 tgggagagcc tagacgagga agcttccgag gtcgaagagg tgtcagacga aacaccgtca 26340 ccctcggtcg cattcccctc gccggcgccc cagaaatcgg caaccggttc cagcatggct 26400 acaacctccg ctcctcaggc gccgccggca ctgcccgttc gccgacccaa ccgtagatgg 26460 gacaccactg gaaccagggc cggtaagtcc aagcagccgc cgccgttagc ccaagagcaa 26520 caacagcgcc aaggctaccg ctcatggcgc gggcacaaga acgccatagt tgcttgcttg 26580 caagactgtg ggggcaacat ctccttcgcc cgccgctttc ttctctacca tcacggcgtg 26640 gccttccccc gtaacatcct gcattactac cgtcatctct acagcccata ctgcaccggc 26700 ggcagcggca gcggcagcaa cagcagcggc cacacagaag caaaggcgac cggatagcaa 26760 gactctgaca aagcccaaga aatccacagc ggcggcagca gcaggaggag gagcgctgcg 26820 tctggcgccc aacgaacccg tatcgacccg cgagcttaga aacaggattt ttcccactct 26880 gtatgctata tttcaacaga gcaggggcca agaacaagag ctgaaaataa aaaacaggtc 26940 tctgcgatcc ctcacccgca gctgcctgta tcacaaaagc gaagatcagc ttcggcgcac 27000 gctggaagac gcggaggctc tcttcagtaa atactgcgcg ctgactctta aggactagtt 27060 tcgcgccctt tctcaaattt aagcgcgaaa actacgtcat ctccagcggc cacacccggc 27120 gccagcacct gtcgtcagcg ccatttatga gcaaggaaat tcccacgccc tacatgtgga 27180 gttaccagcc acaaatggga cttgcggctg gagctgccca agactactca acccgaataa 27240 actacatgag cgcgggaccc cacatgatat cccgggtcaa cggaatacgc gcccaccgaa 27300 accgaattct cctggaacag gcggctatta ccaccacacc tcgtaataac cttaatcccc 27360 gtagttggcc cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc 27420 ccagagacgc ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct 27480 ttcgtcacag ggtgcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag 27540 gtattcagct caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat 27600 ttcagatcgg cggcgccggc cgctcttcat tcacgcctcg tcaggcaatc ctaactctgc 27660 agacctcgtc ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt 27720 ttgtgccatc ggtctacttt aaccccttct cgggacctcc cggccactat ccggatcaat 27780 ttattcctaa ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg 27840 gagaggcaga gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg 27900 cccgcgactc cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg 27960 cgcacggcgt ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta 28020 cccagcgccc cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca 28080 actgtcctaa ccctggatta catcaagatc tttgttgcca tctctgtgct gagtataata 28140 aatacagaaa ttaaaatata ctggggctcc tatcgccatc ctgtaaacgc caccgtcttc 28200 acccgcccaa gcaaaccaag gcgaacctta cctggtactt ttaacatctc tccctctgtg 28260 atttacaaca gtttcaaccc agacggagtg agtctacgag agaacctctc cgagctcagc 28320 tactccatca gaaaaaacac caccctcctt acctgccggg aacgtacgag tgcgtcaccg 28380 gccgctgcac cacacctacc gcctgaccgt aaaccagact ttttccggac agacctcaat 28440 aactctgttt accagaacag gaggtgagct tagaaaaccc ttagggtatt aggccaaagg 28500 cgcagctact gtggggttta tgaacaattc aagcaactct acgggctatt ctaattcagg 28560 tttctctaga atcggggttg gggttattct ctgtcttgtg attctcttta ttcttatact 28620 aacgcttctc tgcctaaggc tcgccgcctg ctgtgtgcac atttgcattt attgtcagct 28680 ttttaaacgc tggggtcgcc acccaagatg attaggtaca taatcctagg tttactcacc 28740 cttgcgtcag cccacggtac cacccaaaag gtggatttta aggagccagc ctgtaatgtt 28800 acattcgcag ctgaagctaa tgagtgcacc actcttataa aatgcaccac agaacatgaa 28860 aagctgctta ttcgccacaa aaacaaaatt ggcaagtatg ctgtttatgc tatttggcag 28920 ccaggtgaca ctacagagta taatgttaca gttttccagg gtaaaagtca taaaactttt 28980 atgtatactt ttccatttta tgaaatgtgc gacattacca tgtacatgag caaacagtat 29040 aagttgtggc ccccacaaaa ttgtgtggaa aacactggca ctttctgctg cactgctatg 29100 ctaattacag tgctcgcttt ggtctgtacc ctactctata ttaaatacaa aagcagacgc 29160 agctttattg aggaaaagaa aatgccttaa tttactaagt tacaaagcta atgtcaccac 29220 taactgcttt actcgctgct tgcaaaacaa attcaaaaag ttagcattat aattagaata 29280 ggatttaaac cccccggtca tttcctgctc aataccattc ccctgaacaa ttgactctat 29340 gtgggatatg ctccagcgct acaaccttga agtcaggctt cctggatgtc agcatctgac 29400 tttggccagc acctgtcccg cggatttgtt ccagtccaac tacagcgacc caccctaaca 29460 gagatgacca acacaaccaa cgcggccgcc gctaccggac ttacatctac cacaaataca 29520 ccccaagttt ctgcctttgt caataactgg gataacttgg gcatgtggtg gttctccata 29580 gcgcttatgt ttgtatgcct tattattatg tggctcatct gctgcctaaa gcgcaaacgc 29640 gcccgaccac ccatctatag tcccatcatt gtgctacacc caaacaatga tggaatccat 29700 agattggacg gactgaaaca catgttcttt tctcttacag tatgattaaa tgagacatga 29760 ttcctcgagt ttttatatta ctgacccttg ttgcgctttt ttgtgcgtgc tccacattgg 29820 ctgcggtttc tcacatcgaa gtagactgca ttccagcctt cacagtctat ttgctttacg 29880 gatttgtcac cctcacgctc atctgcagcc tcatcactgt ggtcatcgcc tttatccagt 29940 gcattgactg ggtctgtgtg cgctttgcat atctcagaca ccatccccag tacagggaca 30000 ggactatagc tgagcttctt agaattcttt aattatgaaa tttactgtga cttttctgct 30060 gattatttgc accctatctg cgttttgttc cccgacctcc aagcctcaaa gacatatatc 30120 atgcagattc actcgtatat ggaatattcc aagttgctac aatgaaaaaa gcgatctttc 30180 cgaagcctgg ttatatgcaa tcatctctgt tatggtgttc tgcagtacca tcttagccct 30240 agctatatat ccctaccttg acattggctg gaacgcaata gatgccatga accacccaac 30300 tttccccgcg cccgctatgc ttccactgca acaagttgtt gccggcggct ttgtcccagc 30360 caatcagcct cgcccacctt ctcccacccc cactgaaatc agctacttta atctaacagg 30420 aggagatgac tgacacccta gatctagaaa tggacggaat tattacagag cagcgcctgc 30480 tagaaagacg cagggcagcg gccgagcaac agcgcatgaa tcaagagctc caagacatgg 30540 ttaacttgca ccagtgcaaa aggggtatct tttgtctggt aaagcaggcc aaagtcacct 30600 acgacagtaa taccaccgga caccgcctta gctacaagtt gccaaccaag cgtcagaaat 30660 tggtggtcat ggtgggagaa aagcccatta ccataactca gcactcggta gaaaccgaag 30720 gctgcattca ctcaccttgt caaggacctg aggatctctg cacccttatt aagaccctgt 30780 gcggtctcaa agatcttatt ccctttaact aataaaaaaa aataataaag catcacttac 30840 ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc 30900 cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg 30960 tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag 31020 cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt 31080 cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt 31140 ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt 31200 gcgctcaaaa tgggcaacgg cctctctctg gacgaggccg gcaaccttac ctcccaaaat 31260 gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct 31320 gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc 31380 gcgggcaaca cactcaccat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt 31440 agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca 31500 ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact 31560 actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa 31620 ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac tttgaccgta 31680 gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc 31740 ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat 31800 tctcaaaaca gacgccttat acttgatgtt agttatccgt ttgatgctca aaaccaacta 31860 aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac 31920 tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac 31980 ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat 32040 gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc 32100 catggcctag aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt 32160 tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg 32220 accacaccag ctccatctcc taactgtaga ctaaatgcag agaaagatgc taaactcact 32280 ttggtcttaa caaaatgtgg cagtcaaata cttgctacag tttcagtttt ggctgttaaa 32340 ggcagtttgg ctccaatatc tggaacagtt caaagtgctc atcttattat aagatttgac 32400 gaaaatggag tgctactaaa caattccttc ctggacccag aatattggaa ctttagaaat 32460 ggagatctta ctgaaggcac agcctataca aacgctgttg gatttatgcc taacctatca 32520 gcttatccaa aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca agtttactta 32580 aacggagaca aaactaaacc tgtaacacta accattacac taaacggtac acaggaaaca 32640 ggagacacaa ctccaagtgc atactctatg tcattttcat gggactggtc tggccacaac 32700 tacattaatg aaatatttgc cacatcctct tacacttttt catacattgc ccaagaataa 32760 agaatcgttt gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcaagtca 32820 tttttcattc agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa 32880 tcaaactcac agaaccctag tattcaacct gccacctccc tcccaacaca cagagtacac 32940 agtcctttct ccccggctgg ccttaaaaag catcatatca tgggtaacag acatattctt 33000 aggtgttata ttccacacgg tttcctgtcg agccaaacgc tcatcagtga tattaataaa 33060 ctccccgggc agctcactta agttcatgtc gctgtccagc tgctgagcca caggctgctg 33120 tccaacttgc ggttgcttaa cgggcggcga aggagaagtc cacgcctaca tgggggtaga 33180 gtcataatcg tgcatcagga tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg 33240 ccgccgccgc tccgtcctgc aggaatacaa catggcagtg gtctcctcag cgatgattcg 33300 caccgcccgc agcataaggc gccttgtcct ccgggcacag cagcgcaccc tgatctcact 33360 taaatcagca cagtaactgc agcacagcac cacaatattg ttcaaaatcc cacagtgcaa 33420 ggcgctgtat ccaaagctca tggcggggac cacagaaccc acgtggccat cataccacaa 33480 gcgcaggtag attaagtggc gacccctcat aaacacgctg gacataaaca ttacctcttt 33540 tggcatgttg taattcacca cctcccggta ccatataaac ctctgattaa acatggcgcc 33600 atccaccacc atcctaaacc agctggccaa aacctgcccg ccggctatac actgcaggga 33660 accgggactg gaacaatgac agtggagagc ccaggactcg taaccatgga tcatcatgct 33720 cgtcatgata tcaatgttgg cacaacacag gcacacgtgc atacacttcc tcaggattac 33780 aagctcctcc cgcgttagaa ccatatccca gggaacaacc cattcctgaa tcagcgtaaa 33840 tcccacactg cagggaagac ctcgcacgta actcacgttg tgcattgtca aagtgttaca 33900 ttcgggcagc agcggatgat cctccagtat ggtagcgcgg gtttctgtct caaaaggagg 33960 tagacgatcc ctactgtacg gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt 34020 catgccaaat ggaacgccgg acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt 34080 gacaaacaga tctgcgtctc cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt 34140 atatccactc tctcaaagca tccaggcgcc ccctggcttc gggttctatg taaactcctt 34200 catgcgccgc tgccctgata acatccacca ccgcagaata agccacaccc agccaaccta 34260 cacattcgtt ctgcgagtca cacacgggag gagcgggaag agctggaaga accatgtttt 34320 tttttttatt ccaaaagatt atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc 34380 tcccctccgg tggcgtggtc aaactctaca gccaaagaac agataatggc atttgtaaga 34440 tgttgcacaa tggcttccaa aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta 34500 aacccttcag ggtgaatctc ctctataaac attccagcac cttcaaccat gcccaaataa 34560 ttctcatctc gccaccttct caatatatct ctaagcaaat cccgaatatt aagtccggcc 34620 attgtaaaaa tctgctccag agcgccctcc accttcagcc tcaagcagcg aatcatgatt 34680 gcaaaaattc aggttcctca cagacctgta taagattcaa aagcggaaca ttaacaaaaa 34740 taccgcgatc ccgtaggtcc cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac 34800 ggaccagcgc ggccacttcc ccgccaggaa ccatgacaaa agaacccaca ctgattatga 34860 cacgcatact cggagctatg ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg 34920 gcgatataaa atgcaaggtg ctgctcaaaa aatcaggcaa agcctcgcgc aaaaaagaaa 34980 gcacatcgta gtcatgctca tgcagataaa ggcaggtaag ctccggaacc accacagaaa 35040 aagacaccat ttttctctca aacatgtctg cgggtttctg cataaacaca aaataaaata 35100 acaaaaaaac atttaaacat tagaagcctg tcttacaaca ggaaaaacaa cccttataag 35160 cataagacgg actacggcca tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa 35220 aagcaccacc gacagctcct cggtcatgtc cggagtcata atgtaagact cggtaaacac 35280 atcaggttga ttcacatcgg tcagtgctaa aaagcgaccg aaatagcccg ggggaataca 35340 tacccgcagg cgtagagaca acattacagc ccccatagga ggtataacaa aattaatagg 35400 agagaaaaac acataaacac ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg 35460 ctccagaaca acatacagcg cttccacagc ggcagccata acagtcagcc ttaccagtaa 35520 aaaagaaaac ctattaaaaa aacaccactc gacacggcac cagctcaatc agtcacagtg 35580 taaaaaaggg ccaagtgcag agcgagtata tataggacta aaaaatgacg taacggttaa 35640 agtccacaaa aaacacccag aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa 35700 aaacccacaa cttcctcaaa tcgtcacttc cgttttccca cgttacgtca cttcccattt 35760 taagaaaact acaattccca acacatacaa gttactccgc cctaaaacct acgtcacccg 35820 ccccgttccc acgccccgcg ccacgtcaca aactccaccc cctcattatc atattggctt 35880 caatccaaaa taaggtatat tattgatgat g 35911 <210> 14 <211> 35632 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO290) <400> 14 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgaccgaaga aatggccgcc agtcttttgg accagctgat 600 cgaagaggta ctggctgata atcttccacc tcctagccat tttgaaccac ctacccttca 660 cgaactgtat gatttagacg tgacggcccc cgaagatccc aacgaggagg cggtttcgca 720 gatttttccc gactctgtaa tgttggcggt gcaggaaggg attgacttac tcacttttcc 780 gccggcgccc ggttctccgg agccgcctca cctttcccgg cagcccgagc agccggagca 840 gagagccttg ggtccggttt ctatgccaaa ccttgtaccg gaggtgatcg atcttacctg 900 ccacgaggct ggctttccac ccagtgacga cgaggatgaa gagggtgagg agtttgtgtt 960 agattatgtg gagcaccccg ggcacggttg caggtcttgt cattatcacc ggaggaatac 1020 gggggaccca gatattatgt gttcgctttg ctatatgagg acctgtggca tgtttgtcta 1080 cagtaagtga aaattatggg cagtgggtga tagagtggtg ggtttggtgt ggtaattttt 1140 tttttaattt ttacagtttt gtggtttaaa gaattttgta ttgtgatttt tttaaaaggt 1200 cctgtgtctg aacctgagcc tgagcccgag ccagaaccgg agcctgcaag acctacccgc 1260 cgtcctaaaa tggcgcctgc tatcctgaga cgcccgacat cacctgtgtc tagagaatgc 1320 aatagtagta cggatagctg tgactccggt ccttctaaca cacctcctga gatacacccg 1380 gtggtcccgc tgtgccccat taaaccagtt gccgtgagag ttggtgggcg tcgccaggct 1440 gtggaatgta tcgaggactt gcttaacgag cctgggcaac ctttggactt gagctgtaaa 1500 cgccccaggc cataaggtgt aaacctgtga ttgcgtgtgt ggttaacgcc tttgtttgct 1560 gaatgagttg atgtaagttt aataaagggt gagataatgt ttaacttgca tggcgtgtta 1620 aatggggcgg ggcttaaagg gtatataatg cgccgtgggc taatcttggt tacatctgac 1680 ctcatggagg cttgggagtg tttggaagat ttttctgctg tgcgtaactt gctggaacag 1740 agctctaaca gtacctcttg gttttggagg tttctgtggg gctcatccca ggcaaagtta 1800 gtctgcagaa ttaaggagga ttacaagtgg gaatttgaag agcttttgaa atcctgtggt 1860 gagctgtttg attctttgaa tctgggtcac caggcgcttt tccaagagaa ggtcatcaag 1920 actttggatt tttccacacc ggggcgcgct gcggctgctg ttgctttttt gagttttata 1980 aaggataaat ggagcgaaga aacccatctg agcggggggt acctgctgga ttttctggcc 2040 atgcatctgt ggagagcggt tgtgagacac aagaatcgcc tgctactgtt gtcttccgtc 2100 cgcccggcga taataccgac ggaggagcag cagcagcagc aggaggaagc caggcggcgg 2160 cggcaggagc agagcccatg gaacccgaga gccggcctgg accctcggga atgaatgttg 2220 tacaggtggc tgaactgtat ccagaactga gacgcatttt gacaattaca gaggatgggc 2280 aggggctaaa gggggtaaag agggagcggg gggcttgtga ggctacagag gaggctagga 2340 atctagcttt tagcttaatg accagacacc gtcctgagtg tattactttt caacagatca 2400 aggataattg cgctaatgag cttgatctgc tggcgcagaa gtattccata gagcagctga 2460 ccacttactg gctgcagcca ggggatgatt ttgaggaggc tattagggta tatgcaaagg 2520 tggcacttag gccagattgc aagtacaaga tcagcaaact tgtaaatatc aggaattgtt 2580 gctacatttc tgggaacggg gccgaggtgg agatagatac ggaggatagg gtggccttta 2640 gatgtagcat gataaatatg tggccggggg tgcttggcat ggacggggtg gttattatga 2700 atgtaaggtt tactggcccc aattttagcg gtacggtttt cctggccaat accaacctta 2760 tcctacacgg tgtaagcttc tatgggttta acaatacctg tgtggaagcc tggaccgatg 2820 taagggttcg gggctgtgcc ttttactgct gctggaaggg ggtggtgtgt cgccccaaaa 2880 gcagggcttc aattaagaaa tgcctctttg aaaggtgtac cttgggtatc ctgtctgagg 2940 gtaactccag ggtgcgccac aatgtggcct ccgactgtgg ttgcttcatg ctagtgaaaa 3000 gcgtggctgt gattaagcat aacatggtat gtggcaactg cgaggacagg gcctctcaga 3060 tgctgacctg ctcggacggc aactgtcacc tgctgaagac cattcacgta gccagccact 3120 ctcgcaaggc ctggccagtg tttgagcata acatactgac ccgctgttcc ttgcatttgg 3180 gtaacaggag gggggtgttc ctaccttacc aatgcaattt gagtcacact aagatattgc 3240 ttgagcccga gagcatgtcc aaggtgaacc tgaacggggt gtttgacatg accatgaaga 3300 tctggaaggt gctgaggtac gatgagaccc gcaccaggtg cagaccctgc gagtgtggcg 3360 gtaaacatat taggaaccag cctgtgatgc tggatgtgac cgaggagctg aggcccgatc 3420 acttggtgct ggcctgcacc cgcgctgagt ttggctctag cgatgaagat acagattgag 3480 gtactgaaat gtgtgggcgt ggcttaaggg tgggaaagaa tatataaggt gggggtctta 3540 tgtagttttg tatctgtttt gcagcagccg ccgccgccat gagcaccaac tcgtttgatg 3600 gaagcattgt gagctcatat ttgacaacgc gcatgccccc atgggccggg gtgcgtcaga 3660 atgtgatggg ctccagcatt gatggtcgcc ccgtcctgcc cgcaaactct actaccttga 3720 cctacgagac cgtgtctgga acgccgttgg agactgcagc ctccgccgcc gcttcagccg 3780 ctgcagccac cgcccgcggg attgtgactg actttgcttt cctgagcccg cttgcaagca 3840 gtgcagcttc ccgttcatcc gcccgcgatg acaagttgac ggctcttttg gcacaattgg 3900 attctttgac ccgggaactt aatgtcgttt ctcagcagct gttggatctg cgccagcagg 3960 tttctgccct gaaggcttcc tcccctccca atgcggttta aaacataaat aaaaaaccag 4020 actctgtttg gatttggatc aagcataagt gtcttgctgt ctttatttag gggttttgcg 4080 cgcgcggtag gcccgggacc agcggtctcg gtcgttgagg gtcctgtgta ttttttccag 4140 gacgtggtaa aggtgactct ggatgttcag atacatgggc ataagcccgt ctctggggtg 4200 gaggtagcac cactgcagag cttcatgctg cggggtggtg ttgtagatga tccagtcgta 4260 gcaggagcgc tgggcgtggt gcctaaaaat gtctttcagt agcaagctga ttgccagggg 4320 caggcccttg gtgtaagtgt ttacaaagcg gttaagctgg gatgggtgca tacgtgggga 4380 tatgagatgc atcttggact gtatttttag gttggctatg ttcccagcca tatccctccg 4440 gggattcatg ttgtgcagaa ccaccagcac agtgtatccg gtgcacttgg gaaatttgtc 4500 atgtagctta gaaggaaatg cgtggaagaa cttggagacg cccttgtgac ctccaagatt 4560 ttccatgcat tcgtccataa tgatggcaat gggcccacgg gcggcggcct gggcgaagat 4620 atttctggga tcactaacgt catagttgtg ttccaggatg agatcgtcat aggccatttt 4680 tacaaagcgc gggcggaggg tgccagactg cggtataatg gttccatccg gcccaggggc 4740 gtagttaccc tcacagattt gcatttccca cgctttgagt tcagatgggg ggatcatgtc 4800 tacctgcggg gcgatgaaga aaacggtttc cggggtaggg gagatcagct gggaagaaag 4860 caggttcctg agcagctgcg acttaccgca gccggtgggc ccgtaaatca cacctattac 4920 cgggtgcaac tggtagttaa gagagctgca gctgccgtca tccctgagca ggggggccac 4980 ttcgttaagc atgtccctga ctcgcatgtt ttccctgacc aaatccgcca gaaggcgctc 5040 gccgcccagc gatagcagtt cttgcaagga agcaaagttt ttcaacggtt tgagaccgtc 5100 cgccgtaggc atgcttttga gcgtttgacc aagcagttcc aggcggtccc acagctcggt 5160 cacctgctct acggcatctc gatccagcat atctcctcgt ttcgcgggtt ggggcggctt 5220 tcgctgtacg gcagtagtcg gtgctcgtcc agacgggcca gggtcatgtc tttccacggg 5280 cgcagggtcc tcgtcagcgt agtctgggtc acggtgaagg ggtgcgctcc gggctgcgcg 5340 ctggccaggg tgcgcttgag gctggtcctg ctggtgctga agcgctgccg gtcttcgccc 5400 tgcgcgtcgg ccaggtagca tttgaccatg gtgtcatagt ccagcccctc cgcggcgtgg 5460 cccttggcgc gcagcttgcc cttggaggag gcgccgcacg aggggcagtg cagacttttg 5520 agggcgtaga gcttgggcgc gagaaatacc gattccgggg agtaggcatc cgcgccgcag 5580 gccccgcaga cggtctcgca ttccacgagc caggtgagct ctggccgttc ggggtcaaaa 5640 accaggtttc ccccatgctt tttgatgcgt ttcttacctc tggtttccat gagccggtgt 5700 ccacgctcgg tgacgaaaag gctgtccgtg tccccgtata cagacttgag aggcctgtcc 5760 tcgagcggtg ttccgcggtc ctcctcgtat agaaactcgg accactctga gacaaaggct 5820 cgcgtccagg ccagcacgaa ggaggctaag tgggaggggt agcggtcgtt gtccactagg 5880 gggtccactc gctccagggt gtgaagacac atgtcgccct cttcggcatc aaggaaggtg 5940 attggtttgt aggtgtaggc cacgtgaccg ggtgttcctg aaggggggct ataaaagggg 6000 gtgggggcgc gttcgtcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg 6060 ggtgagtact ccctctgaaa agcgggcatg acttctgcgc taagattgtc agtttccaaa 6120 aacgaggagg atttgatatt cacctggccc gcggtgatgc ctttgagggt ggccgcatcc 6180 atctggtcag aaaagacaat ctttttgttg tcaagcttgg tggcaaacga cccgtagagg 6240 gcgttggaca gcaacttggc gatggagcgc agggtttggt ttttgtcgcg atcggcgcgc 6300 tccttggccg cgatgtttag ctgcacgtat tcgcgcgcaa cgcaccgcca ttcgggaaag 6360 acggtggtgc gctcgtcggg caccaggtgc acgcgccaac cgcggttgtg cagggtgaca 6420 aggtcaacgc tggtggctac ctctccgcgt aggcgctcgt tggtccagca gaggcggccg 6480 cccttgcgcg agcagaatgg cggtaggggg tctagctgcg tctcgtccgg ggggtctgcg 6540 tccacggtaa agaccccggg cagcaggcgc gcgtcgaagt agtctatctt gcatccttgc 6600 aagtctagcg cctgctgcca tgcgcgggcg gcaagcgcgc gctcgtatgg gttgagtggg 6660 ggaccccatg gcatggggtg ggtgagcgcg gaggcgtaca tgccgcaaat gtcgtaaacg 6720 tagaggggct ctctgagtat tccaagatat gtagggtagc atcttccacc gcggatgctg 6780 gcgcgcacgt aatcgtatag ttcgtgcgag ggagcgagga ggtcgggacc gaggttgcta 6840 cgggcgggct gctctgctcg gaagactatc tgcctgaaga tggcatgtga gttggatgat 6900 atggttggac gctggaagac gttgaagctg gcgtctgtga gacctaccgc gtcacgcacg 6960 aaggaggcgt aggagtcgcg cagcttgttg accagctcgg cggtgacctg cacgtctagg 7020 gcgcagtagt ccagggtttc cttgatgatg tcatacttat cctgtccctt ttttttccac 7080 agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt actcttggat cggaaacccg 7140 tcggcctccg aacggtaaga gcctagcatg tagaactggt tgacggcctg gtaggcgcag 7200 catccctttt ctacgggtag cgcgtatgcc tgcgcggcct tccggagcga ggtgtgggtg 7260 agcgcaaagg tgtccctgac catgactttg aggtactggt atttgaagtc agtgtcgtcg 7320 catccgccct gctcccagag caaaaagtcc gtgcgctttt tggaacgcgg atttggcagg 7380 gcgaaggtga catcgttgaa gagtatcttt cccgcgcgag gcataaagtt gcgtgtgatg 7440 cggaagggtc ccggcacctc ggaacggttg ttaattacct gggcggcgag cacgatctcg 7500 tcaaagccgt tgatgttgtg gcccacaatg taaagttcca agaagcgcgg gatgcccttg 7560 atggaaggca attttttaag ttcctcgtag gtgagctctt caggggagct gagcccgtgc 7620 tctgaaaggg cccagtctgc aagatgaggg ttggaagcga cgaatgagct ccacaggtca 7680 cgggccatta gcatttgcag gtggtcgcga aaggtcctaa actggcgacc tatggccatt 7740 ttttctgggg tgatgcagta gaaggtaagc gggtcttgtt cccagcggtc ccatccaagg 7800 ttcgcggcta ggtctcgcgc ggcagtcact agaggctcat ctccgccgaa cttcatgacc 7860 agcatgaagg gcacgagctg cttcccaaag gcccccatcc aagtataggt ctctacatcg 7920 taggtgacaa agagacgctc ggtgcgagga tgcgagccga tcgggaagaa ctggatctcc 7980 cgccaccaat tggaggagtg gctattgatg tggtgaaagt agaagtccct gcgacgggcc 8040 gaacactcgt gctggctttt gtaaaaacgt gcgcagtact ggcagcggtg cacgggctgt 8100 acatcctgca cgaggttgac ctgacgaccg cgcacaagga agcagagtgg gaatttgagc 8160 ccctcgcctg gcgggtttgg ctggtggtct tctacttcgg ctgcttgtcc ttgaccgtct 8220 ggctgctcga ggggagttac ggtggatcgg accaccacgc cgcgcgagcc caaagtccag 8280 atgtccgcgc gcggcggtcg gagcttgatg acaacatcgc gcagatggga gctgtccatg 8340 gtctggagct cccgcggcgt caggtcaggc gggagctcct gcaggtttac ctcgcataga 8400 cgggtcaggg cgcgggctag atccaggtga tacctaattt ccaggggctg gttggtggcg 8460 gcgtcgatgg cttgcaagag gccgcatccc cgcggcgcga ctacggtacc gcgcggcggg 8520 cggtgggccg cgggggtgtc cttggatgat gcatctaaaa gcggtgacgc gggcgagccc 8580 ccggaggtag ggggggctcc ggacccgccg ggagaggggg caggggcacg tcggcgccgc 8640 gcgcgggcag gagctggtgc tgcgcgcgta ggttgctggc gaacgcgacg acgcggcggt 8700 tgatctcctg aatctggcgc ctctgcgtga agacgacggg cccggtgagc ttgagcctga 8760 aagagagttc gacagaatca atttcggtgt cgttgacggc ggcctggcgc aaaatctcct 8820 gcacgtctcc tgagttgtct tgataggcga tctcggccat gaactgctcg atctcttcct 8880 cctggagatc tccgcgtccg gctcgctcca cggtggcggc gaggtcgttg gaaatgcggg 8940 ccatgagctg cgagaaggcg ttgaggcctc cctcgttcca gacgcggctg tagaccacgc 9000 ccccttcggc atcgcgggcg cgcatgacca cctgcgcgag attgagctcc acgtgccggg 9060 cgaagacggc gtagtttcgc aggcgctgaa agaggtagtt gagggtggtg gcggtgtgtt 9120 ctgccacgaa gaagtacata acccagcgtc gcaacgtgga ttcgttgata tcccccaagg 9180 cctcaaggcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc 9240 gcgccgacac ggttaactcc tcctccagaa gacggatgag ctcggcgaca gtgtcgcgca 9300 cctcgcgctc aaaggctaca ggggcctctt cttcttcttc aatctcctct tccataaggg 9360 cctccccttc ttcttcttct ggcggcggtg ggggaggggg gacacggcgg cgacgacggc 9420 gcaccgggag gcggtcgaca aagcgctcga tcatctcccc gcggcgacgg cgcatggtct 9480 cggtgacggc gcggccgttc tcgcgggggc gcagttggaa gacgccgccc gtcatgtccc 9540 ggttatgggt tggcgggggg ctgccatgcg gcagggatac ggcgctaacg atgcatctca 9600 acaattgttg tgtaggtact ccgccgccga gggacctgag cgagtccgca tcgaccggat 9660 cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc gcaaggtagg ctgagcaccg 9720 tggcgggcgg cagcgggcgg cggtcggggt tgtttctggc ggaggtgctg ctgatgatgt 9780 aattaaagta ggcggtcttg agacggcgga tggtcgacag aagcaccatg tccttgggtc 9840 cggcctgctg aatgcgcagg cggtcggcca tgccccaggc ttcgttttga catcggcgca 9900 ggtctttgta gtagtcttgc atgagccttt ctaccggcac ttcttcttct ccttcctctt 9960 gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga gtttggccgt aggtggcgcc 10020 ctcttcctcc catgcgtgtg accccgaagc ccctcatcgg ctgaagcagg gctaggtcgg 10080 cgacaacgcg ctcggctaat atggcctgct gcacctgcgt gagggtagac tggaagtcat 10140 ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt gtaagtgcag ttggccataa 10200 cggaccagtt aacggtctgg tgacccggct gcgagagctc ggtgtacctg agacgcgagt 10260 aagccctcga gtcaaatacg tagtcgttgc aagtccgcac caggtactgg tatcccacca 10320 aaaagtgcgg cggcggctgg cggtagaggg gccagcgtag ggtggccggg gctccggggg 10380 cgagatcttc caacataagg cgatgatatc cgtagatgta cctggacatc caggtgatgc 10440 cggcggcggt ggtggaggcg cgcggaaagt cgcggacgcg gttccagatg ttgcgcagcg 10500 gcaaaaagtg ctccatggtc gggacgctct ggccggtcag gcgcgcgcaa tcgttgacgc 10560 tctagaccgt gcaaaaggag agcctgtaag cgggcactct tccgtggtct ggtggataaa 10620 ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc cgtatccggc cgtccgccgt 10680 gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga caacggggga 10740 gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc gctagctttt ttggccactg 10800 gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc tcgctccctg 10860 tagccggagg gttattttcc aagggttgag tcgcgggacc cccggttcga gtctcggacc 10920 ggccggactg cggcgaacgg gggtttgcct ccccgtcatg caagaccccg cttgcaaatt 10980 cctccggaaa cagggacgag cccctttttt gcttttccca gatgcatccg gtgctgcggc 11040 agatgcgccc ccctcctcag cagcggcaag agcaagagca gcggcagaca tgcagggcac 11100 cctcccctcc tcctaccgcg tcaggagggg cgacatccgc ggttgacgcg gcagcagatg 11160 gtgattacga acccccgcgg cgccgggccc ggcactacct ggacttggag gagggcgagg 11220 gcctggcgcg gctaggagcg ccctctcctg agcggtaccc aagggtgcag ctgaagcgtg 11280 atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg cgaccgcgag ggagaggagc 11340 ccgaggagat gcgggatcga aagttccacg cagggcgcga gctgcggcat ggcctgaatc 11400 gcgagcggtt gctgcgcgag gaggactttg agcccgacgc gcgaaccggg attagtcccg 11460 cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata cgagcagacg gtgaaccagg 11520 agattaactt tcaaaaaagc tttaacaacc acgtgcgtac gcttgtggcg cgcgaggagg 11580 tggctatagg actgatgcat ctgtgggact ttgtaagcgc gctggagcaa aacccaaata 11640 gcaagccgct catggcgcag ctgttcctta tagtgcagca cagcagggac aacgaggcat 11700 tcagggatgc gctgctaaac atagtagagc ccgagggccg ctggctgctc gatttgataa 11760 acatcctgca gagcatagtg gtgcaggagc gcagcttgag cctggctgac aaggtggccg 11820 ccatcaacta ttccatgctt agcctgggca agttttacgc ccgcaagata taccataccc 11880 cttacgttcc catagacaag gaggtaaaga tcgaggggtt ctacatgcgc atggcgctga 11940 aggtgcttac cttgagcgac gacctgggcg tttatcgcaa cgagcgcatc cacaaggccg 12000 tgagcgtgag ccggcggcgc gagctcagcg accgcgagct gatgcacagc ctgcaaaggg 12060 ccctggctgg cacgggcagc ggcgatagag aggccgagtc ctactttgac gcgggcgctg 12120 acctgcgctg ggccccaagc cgacgcgccc tggaggcagc tggggccgga cctgggctgg 12180 cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga ggaatatgac gaggacgatg 12240 agtacgagcc agaggacggc gagtactaag cggtgatgtt tctgatcaga tgatgcaaga 12300 cgcaacggac ccggcggtgc gggcggcgct gcagagccag ccgtccggcc ttaactccac 12360 ggacgactgg cgccaggtca tggaccgcat catgtcgctg actgcgcgca atcctgacgc 12420 gttccggcag cagccgcagg ccaaccggct ctccgcaatt ctggaagcgg tggtcccggc 12480 gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta aacgcgctgg ccgaaaacag 12540 ggccatccgg cccgacgagg ccggcctggt ctacgacgcg ctgcttcagc gcgtggctcg 12600 ttacaacagc ggcaacgtgc agaccaacct ggaccggctg gtgggggatg tgcgcgaggc 12660 cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg ggctccatgg ttgcactaaa 12720 cgccttcctg agtacacagc ccgccaacgt gccgcgggga caggaggact acaccaactt 12780 tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa agtgaggtgt accagtctgg 12840 gccagactat tttttccaga ccagtagaca aggcctgcag accgtaaacc tgagccaggc 12900 tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc acaggcgacc gcgcgaccgt 12960 gtctagcttg ctgacgccca actcgcgcct gttgctgctg ctaatagcgc ccttcacgga 13020 cagtggcagc gtgtcccggg acacatacct aggtcacttg ctgacactgt accgcgaggc 13080 cataggtcag gcgcatgtgg acgagcatac tttccaggag attacaagtg tcagccgcgc 13140 gctggggcag gaggacacgg gcagcctgga ggcaacccta aactacctgc tgaccaaccg 13200 gcggcagaag atcccctcgt tgcacagttt aaacagcgag gaggagcgca ttttgcgcta 13260 cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg gtaacgccca gcgtggcgct 13320 ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc tcaaaccggc cgtttatcaa 13380 ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac cccgagtatt tcaccaatgc 13440 catcttgaac ccgcactggc taccgccccc tggtttctac accgggggat tcgaggtgcc 13500 cgagggtaac gatggattcc tctgggacga catagacgac agcgtgtttt ccccgcaacc 13560 gcagaccctg ctagagttgc aacagcgcga gcaggcagag gcggcgctgc gaaaggaaag 13620 cttccgcagg ccaagcagct tgtccgatct aggcgctgcg gccccgcggt cagatgctag 13680 tagcccattt ccaagcttga tagggtctct taccagcact cgcaccaccc gcccgcgcct 13740 gctgggcgag gaggagtacc taaacaactc gctgctgcag ccgcagcgcg aaaaaaacct 13800 gcctccggca tttcccaaca acgggataga gagcctagtg gacaagatga gtagatggaa 13860 gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc ccgcccaccc gtcgtcaaag 13920 gcacgaccgt cagcggggtc tggtgtggga ggacgatgac tcggcagacg acagcagcgt 13980 cctggatttg ggagggagtg gcaacccgtt tgcgcacctt cgccccaggc tggggagaat 14040 gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc accaaggcca tggcaccgag 14100 cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg cgatgtatga ggaaggtcct 14160 cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg cggcggcgct gggttctccc 14220 ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt acctgcggcc taccgggggg 14280 agaaacagca tccgttactc tgagttggca cccctattcg acaccacccg tgtgtacctg 14340 gtggacaaca agtcaacgga tgtggcatcc ctgaactacc agaacgacca cagcaacttt 14400 ctgaccacgg tcattcaaaa caatgactac agcccggggg aggcaagcac acagaccatc 14460 aatcttgacg accggtcgca ctggggcggc gacctgaaaa ccatcctgca taccaacatg 14520 ccaaatgtga acgagttcat gtttaccaat aagtttaagg cgcgggtgat ggtgtcgcgc 14580 ttgcctacta aggacaatca ggtggagctg aaatacgagt gggtggagtt cacgctgccc 14640 gagggcaact actccgagac catgaccata gaccttatga acaacgcgat cgtggagcac 14700 tacttgaaag tgggcagaca gaacggggtt ctggaaagcg acatcggggt aaagtttgac 14760 acccgcaact tcagactggg gtttgacccc gtcactggtc ttgtcatgcc tggggtatat 14820 acaaacgaag ccttccatcc agacatcatt ttgctgccag gatgcggggt ggacttcacc 14880 cacagccgcc tgagcaactt gttgggcatc cgcaagcggc aacccttcca ggagggcttt 14940 aggatcacct acgatgatct ggagggtggt aacattcccg cactgttgga tgtggacgcc 15000 taccaggcga gcttgaaaga tgacaccgaa cagggcgggg gtggcgcagg cggcagcaac 15060 agcagtggca gcggcgcgga agagaactcc aacgcggcag ccgcggcaat gcagccggtg 15120 gaggacatga acgatcatgc cattcgcggc gacacctttg ccacacgggc tgaggagaag 15180 cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg ctgcgcaacc cgaggtcgag 15240 aagcctcaga agaaaccggt gatcaaaccc ctgacagagg acagcaagaa acgcagttac 15300 aacctaataa gcaatgacag caccttcacc cagtaccgca gctggtacct tgcatacaac 15360 tacggcgacc ctcagaccgg aatccgctca tggaccctgc tttgcactcc tgacgtaacc 15420 tgcggctcgg agcaggtcta ctggtcgttg ccagacatga tgcaagaccc cgtgaccttc 15480 cgctccacgc gccagatcag caactttccg gtggtgggcg ccgagctgtt gcccgtgcac 15540 tccaagagct tctacaacga ccaggccgtc tactcccaac tcatccgcca gtttacctct 15600 ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc gccagccccc 15660 accatcacca ccgtcagtga aaacgttcct gctctcacag atcacgggac gctaccgctg 15720 cgcaacagca tcggaggagt ccagcgagtg accattactg acgccagacg ccgcacctgc 15780 ccctacgttt acaaggccct gggcatagtc tcgccgcgcg tcctatcgag ccgcactttt 15840 tgagcaagca tgtccatcct tatatcgccc agcaataaca caggctgggg cctgcgcttc 15900 ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc aacacccagt gcgcgtgcgc 15960 gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc gcactgggcg caccaccgtc 16020 gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact acacgcccac gccgccacca 16080 gtgtccacag tggacgcggc cattcagacc gtggtgcgcg gagcccggcg ctatgctaaa 16140 atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc gccgacccgg cactgccgcc 16200 caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca ccggccgacg ggcggccatg 16260 cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc cccccaggtc caggcgacga 16320 gcggccgccg cagcagccgc ggccattagt gctatgactc agggtcgcag gggcaacgtg 16380 tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg tgcgcacccg ccccccgcgc 16440 aactagattg caagaaaaaa ctacttagac tcgtactgtt gtatgtatcc agcggcggcg 16500 gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag agatgctcca ggtcatcgcg 16560 ccggagatct atggcccccc gaagaaggaa gagcaggatt acaagccccg aaagctaaag 16620 cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg acgacgaggt ggaactgctg 16680 cacgctaccg cgcccaggcg acgggtacag tggaaaggtc gacgcgtaaa acgtgttttg 16740 cgacccggca ccaccgtagt ctttacgccc ggtgagcgct ccacccgcac ctacaagcgc 16800 gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc aggccaacga gcgcctcggg 16860 gagtttgcct acggaaagcg gcataaggac atgctggcgt tgccgctgga cgagggcaac 16920 ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc tgcccgcgct tgcaccgtcc 16980 gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg cacccaccgt gcagctgatg 17040 gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa tgaccgtgga acctgggctg 17100 gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc cgggactggg cgtgcagacc 17160 gtggacgttc agatacccac taccagtagc accagtattg ccaccgccac agagggcatg 17220 gagacacaaa cgtccccggt tgcctcagcg gtggcggatg ccgcggtgca ggcggtcgct 17280 gcggccgcgt ccaagacctc tacggaggtg caaacggacc cgtggatgtt tcgcgtttca 17340 gccccccggc gcccgcgcgg ttcgaggaag tacggcgccg ccagcgcgct actgcccgaa 17400 tatgccctac atccttccat tgcgcctacc cccggctatc gtggctacac ctaccgcccc 17460 agaagacgag caactacccg acgccgaacc accactggaa cccgccgccg ccgtcgccgt 17520 cgccagcccg tgctggcccc gatttccgtg cgcagggtgg ctcgcgaagg aggcaggacc 17580 ctggtgctgc caacagcgcg ctaccacccc agcatcgttt aaaagccggt ctttgtggtt 17640 cttgcagata tggccctcac ctgccgcctc cgtttcccgg tgccgggatt ccgaggaaga 17700 atgcaccgta ggaggggcat ggccggccac ggcctgacgg gcggcatgcg tcgtgcgcac 17760 caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg gtatcctgcc cctccttatt 17820 ccactgatcg ccgcggcgat tggcgccgtg cccggaattg catccgtggc cttgcaggcg 17880 cagagacact gattaaaaac aagttgcatg tggaaaaatc aaaataaaaa gtctggactc 17940 tcacgctcgc ttggtcctgt aactattttg tagaatggaa gacatcaact ttgcgtctct 18000 ggccccgcga cacggctcgc gcccgttcat gggaaactgg caagatatcg gcaccagcaa 18060 tatgagcggt ggcgccttca gctggggctc gctgtggagc ggcattaaaa atttcggttc 18120 caccgttaag aactatggca gcaaggcctg gaacagcagc acaggccaga tgctgaggga 18180 taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat ggcctggcct ctggcattag 18240 cggggtggtg gacctggcca accaggcagt gcaaaataag attaacagta agcttgatcc 18300 ccgccctccc gtagaggagc ctccaccggc cgtggagaca gtgtctccag aggggcgtgg 18360 cgaaaagcgt ccgcgccccg acagggaaga aactctggtg acgcaaatag acgagcctcc 18420 ctcgtacgag gaggcactaa agcaaggcct gcccaccacc cgtcccatcg cgcccatggc 18480 taccggagtg ctgggccagc acacacccgt aacgctggac ctgcctcccc ccgccgacac 18540 ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt gtaacccgtc ctagccgcgc 18600 gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg cccgtagcca gtggcaactg 18660 gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa tccctgaagc gccgacgatg 18720 cttctgaata gctaacgtgt cgtatgtgtg tcatgtatgc gtccatgtcg ccgccagagg 18780 agctgctgag ccgccgcgcg cccgctttcc aagatggcta ccccttcgat gatgccgcag 18840 tggtcttaca tgcacatctc gggccaggac gcctcggagt acctgagccc cgggctggtg 18900 cagtttgccc gcgccaccga gacgtacttc agcctgaata acaagtttag aaaccccacg 18960 gtggcgccta cgcacgacgt gaccacagac cggtcccagc gtttgacgct gcggttcatc 19020 cctgtggacc gtgaggatac tgcgtactcg tacaaggcgc ggttcaccct agctgtgggt 19080 gataaccgtg tgctggacat ggcttccacg tactttgaca tccgcggcgt gctggacagg 19140 ggccctactt ttaagcccta ctctggcact gcctacaacg ccctggctcc caagggtgcc 19200 ccaaatcctt gcgaatggga tgaagctgct actgctcttg aaataaacct agaagaagag 19260 gacgatgaca acgaagacga agtagacgag caagctgagc agcaaaaaac tcacgtattt 19320 gggcaggcgc cttattctgg tataaatatt acaaaggagg gtattcaaat aggtgtcgaa 19380 ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg aacctcaaat aggagaatct 19440 cagtggtacg aaactgaaat taatcatgca gctgggagag tccttaaaaa gactacccca 19500 atgaaaccat gttacggttc atatgcaaaa cccacaaatg aaaatggagg gcaaggcatt 19560 cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg aaatgcaatt tttctcaact 19620 actgaggcga ccgcaggcaa tggtgataac ttgactccta aagtggtatt gtacagtgaa 19680 gatgtagata tagaaacccc agacactcat atttcttaca tgcccactat taaggaaggt 19740 aactcacgag aactaatggg ccaacaatct atgcccaaca ggcctaatta cattgctttt 19800 agggacaatt ttattggtct aatgtattac aacagcacgg gtaatatggg tgttctggcg 19860 ggccaagcat cgcagttgaa tgctgttgta gatttgcaag acagaaacac agagctttca 19920 taccagcttt tgcttgattc cattggtgat agaaccaggt acttttctat gtggaatcag 19980 gctgttgaca gctatgatcc agatgttaga attattgaaa atcatggaac tgaagatgaa 20040 cttccaaatt actgctttcc actgggaggt gtgattaata cagagactct taccaaggta 20100 aaacctaaaa caggtcagga aaatggatgg gaaaaagatg ctacagaatt ttcagataaa 20160 aatgaaataa gagttggaaa taattttgcc atggaaatca atctaaatgc caacctgtgg 20220 agaaatttcc tgtactccaa catagcgctg tatttgcccg acaagctaaa gtacagtcct 20280 tccaacgtaa aaatttctga taacccaaac acctacgact acatgaacaa gcgagtggtg 20340 gctcccgggt tagtggactg ctacattaac cttggagcac gctggtccct tgactatatg 20400 gacaacgtca acccatttaa ccaccaccgc aatgctggcc tgcgctaccg ctcaatgttg 20460 ctgggcaatg gtcgctatgt gcccttccac atccaggtgc ctcagaagtt ctttgccatt 20520 aaaaacctcc ttctcctgcc gggctcatac acctacgagt ggaacttcag gaaggatgtt 20580 aacatggttc tgcagagctc cctaggaaat gacctaaggg ttgacggagc cagcattaag 20640 tttgatagca tttgccttta cgccaccttc ttccccatgg cccacaacac cgcctccacg 20700 cttgaggcca tgcttagaaa cgacaccaac gaccagtcct ttaacgacta tctctccgcc 20760 gccaacatgc tctaccctat acccgccaac gctaccaacg tgcccatatc catcccctcc 20820 cgcaactggg cggctttccg cggctgggcc ttcacgcgcc ttaagactaa ggaaacccca 20880 tcactgggct cgggctacga cccttattac acctactctg gctctatacc ctacctagat 20940 ggaacctttt acctcaacca cacctttaag aaggtggcca ttacctttga ctcttctgtc 21000 agctggcctg gcaatgaccg cctgcttacc cccaacgagt ttgaaattaa gcgctcagtt 21060 gacggggagg gttacaacgt tgcccagtgt aacatgacca aagactggtt cctggtacaa 21120 atgctagcta actacaacat tggctaccag ggcttctata tcccagagag ctacaaggac 21180 cgcatgtact ccttctttag aaacttccag cccatgagcc gtcaggtggt ggatgatact 21240 aaatacaagg actaccaaca ggtgggcatc ctacaccaac acaacaactc tggatttgtt 21300 ggctaccttg cccccaccat gcgcgaagga caggcctacc ctgctaactt cccctatccg 21360 cttataggca agaccgcagt tgacagcatt acccagaaaa agtttctttg cgatcgcacc 21420 ctttggcgca tcccattctc cagtaacttt atgtccatgg gcgcactcac agacctgggc 21480 caaaaccttc tctacgccaa ctccgcccac gcgctagaca tgacttttga ggtggatccc 21540 atggacgagc ccacccttct ttatgttttg tttgaagtct ttgacgtggt ccgtgtgcac 21600 cggccgcacc gcggcgtcat cgaaaccgtg tacctgcgca cgcccttctc ggccggcaac 21660 gccacaacat aaagaagcaa gcaacatcaa caacagctgc cgccatgggc tccagtgagc 21720 aggaactgaa agccattgtc aaagatcttg gttgtgggcc atattttttg ggcacctatg 21780 acaagcgctt tccaggcttt gtttctccac acaagctcgc ctgcgccata gtcaatacgg 21840 ccggtcgcga gactgggggc gtacactgga tggcctttgc ctggaacccg cactcaaaaa 21900 catgctacct ctttgagccc tttggctttt ctgaccagcg actcaagcag gtttaccagt 21960 ttgagtacga gtcactcctg cgccgtagcg ccattgcttc ttcccccgac cgctgtataa 22020 cgctggaaaa gtccacccaa agcgtacagg ggcccaactc ggccgcctgt ggactattct 22080 gctgcatgtt tctccacgcc tttgccaact ggccccaaac tcccatggat cacaacccca 22140 ccatgaacct tattaccggg gtacccaact ccatgctcaa cagtccccag gtacagccca 22200 ccctgcgtcg caaccaggaa cagctctaca gcttcctgga gcgccactcg ccctacttcc 22260 gcagccacag tgcgcagatt aggagcgcca cttctttttg tcacttgaaa aacatgtaaa 22320 aataatgtac tagagacact ttcaataaag gcaaatgctt ttatttgtac actctcgggt 22380 gattatttac ccccaccctt gccgtctgcg ccgtttaaaa atcaaagggg ttctgccgcg 22440 catcgctatg cgccactggc agggacacgt tgcgatactg gtgtttagtg ctccacttaa 22500 actcaggcac aaccatccgc ggcagctcgg tgaagttttc actccacagg ctgcgcacca 22560 tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa gtcgcagttg gggcctccgc 22620 cctgcgcgcg cgagttgcga tacacagggt tgcagcactg gaacactatc agcgccgggt 22680 ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc cgcgtccagg tcctccgcgt 22740 tgctcagggc gaacggagtc aactttggta gctgccttcc caaaaagggc gcgtgcccag 22800 gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg accgtgcccg gtctgggcgt 22860 taggatacag cgcctgcata aaagccttga tctgcttaaa agccacctga gcctttgcgc 22920 cttcagagaa gaacatgccg caagacttgc cggaaaactg attggccgga caggccgcgt 22980 cgtgcacgca gcaccttgcg tcggtgttgg agatctgcac cacatttcgg ccccaccggt 23040 tcttcacgat cttggccttg ctagactgct ccttcagcgc gcgctgcccg ttttcgctcg 23100 tcacatccat ttcaatcacg tgctccttat ttatcataat gcttccgtgt agacacttaa 23160 gctcgccttc gatctcagcg cagcggtgca gccacaacgc gcagcccgtg ggctcgtgat 23220 gcttgtaggt cacctctgca aacgactgca ggtacgcctg caggaatcgc cccatcatcg 23280 tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc gcggtgctcc tcgttcagcc 23340 aggtcttgca tacggccgcc agagcttcca cttggtcagg cagtagtttg aagttcgcct 23400 ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg cgcagcctcc atgcccttct 23460 cccacgcaga cacgatcggc acactcagcg ggttcatcac cgtaatttca ctttccgctt 23520 cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg cgccactggg tcgtcttcat 23580 tcagccgccg cactgtgcgc ttacctcctt tgccatgctt gattagcacc ggtgggttgc 23640 tgaaacccac catttgtagc gccacatctt ctctttcttc ctcgctgtcc acgattacct 23700 ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt ctttttcttc ttgggcgcaa 23760 tggccaaatc cgccgccgag gtcgatggcc gcgggctggg tgtgcgcggc accagcgcgt 23820 cttgtgatga gtcttcctcg tcctcggact cgatacgccg cctcatccgc ttttttgggg 23880 gcgcccgggg aggcggcggc gacggggacg gggacgacac gtcctccatg gttgggggac 23940 gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg ctgctcctct tcccgactgg 24000 ccatttcctt ctcctatagg cagaaaaaga tcatggagtc agtcgagaag aaggacagcc 24060 taaccgcccc ctctgagttc gccaccaccg cctccaccga tgccgccaac gcgcctacca 24120 ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt gattatcgag caggacccag 24180 gttttgtaag cgaagacgac gaggaccgct cagtaccaac agaggataaa aagcaagacc 24240 aggacaacgc agaggcaaac gaggaacaag tcgggcgggg ggacgaaagg catggcgact 24300 acctagatgt gggagacgac gtgctgttga agcatctgca gcgccagtgc gccattatct 24360 gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat agcggatgtc agccttgcct 24420 acgaacgcca cctattctca ccgcgcgtac cccccaaacg ccaagaaaac ggcacatgcg 24480 agcccaaccc gcgcctcaac ttctaccccg tatttgccgt gccagaggtg cttgccacct 24540 atcacatctt tttccaaaac tgcaagatac ccctatcctg ccgtgccaac cgcagccgag 24600 cggacaagca gctggccttg cggcagggcg ctgtcatacc tgatatcgcc tcgctcaacg 24660 aagtgccaaa aatctttgag ggtcttggac gcgacgagaa gcgcgcggca aacgctctgc 24720 aacaggaaaa cagcgaaaat gaaagtcact ctggagtgtt ggtggaactc gagggtgaca 24780 acgcgcgcct agccgtacta aaacgcagca tcgaggtcac ccactttgcc tacccggcac 24840 ttaacctacc ccccaaggtc atgagcacag tcatgagtga gctgatcgtg cgccgtgcgc 24900 agcccctgga gagggatgca aatttgcaag aacaaacaga ggagggccta cccgcagttg 24960 gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc tgccgacttg gaggagcgac 25020 gcaaactaat gatggccgca gtgctcgtta ccgtggagct tgagtgcatg cagcggttct 25080 ttgctgaccc ggagatgcag cgcaagctag aggaaacatt gcactacacc tttcgacagg 25140 gctacgtacg ccaggcctgc aagatctcca acgtggagct ctgcaacctg gtctcctacc 25200 ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct tcattccacg ctcaagggcg 25260 aggcgcgccg cgactacgtc cgcgactgcg tttacttatt tctatgctac acctggcaga 25320 cggccatggg cgtttggcag cagtgcttgg aggagtgcaa cctcaaggag ctgcagaaac 25380 tgctaaagca aaacttgaag gacctatgga cggccttcaa cgagcgctcc gtggccgcgc 25440 acctggcgga catcattttc cccgaacgcc tgcttaaaac cctgcaacag ggtctgccag 25500 acttcaccag tcaaagcatg ttgcagaact ttaggaactt tatcctagag cgctcaggaa 25560 tcttgcccgc cacctgctgt gcacttccta gcgactttgt gcccattaag taccgcgaat 25620 gccctccgcc gctttggggc cactgctacc ttctgcagct agccaactac cttgcctacc 25680 actctgacat aatggaagac gtgagcggtg acggtctact ggagtgtcac tgtcgctgca 25740 acctatgcac cccgcaccgc tccctggttt gcaattcgca gctgcttaac gaaagtcaaa 25800 ttatcggtac ctttgagctg cagggtccct cgcctgacga aaagtccgcg gctccggggt 25860 tgaaactcac tccggggctg tggacgtcgg cttaccttcg caaatttgta cctgaggact 25920 accacgccca cgagattagg ttctacgaag accaatcccg cccgccaaat gcggagctta 25980 ccgcctgcgt cattacccag ggccacattc ttggccaatt gcaagccatc aacaaagccc 26040 gccaagagtt tctgctacga aagggacggg gggtttactt ggacccccag tccggcgagg 26100 agctcaaccc aatccccccg ccgccgcagc cctatcagca gcagccgcgg gcccttgctt 26160 cccaggatgg cacccaaaaa gaagctgcag ctgccgccgc cacccacgga cgaggaggaa 26220 tactgggaca gtcaggcaga ggaggttttg gacgaggagg aggaggacat gatggaagac 26280 tgggagagcc tagacgagga agcttccgag gtcgaagagg tgtcagacga aacaccgtca 26340 ccctcggtcg cattcccctc gccggcgccc cagaaatcgg caaccggttc cagcatggct 26400 acaacctccg ctcctcaggc gccgccggca ctgcccgttc gccgacccaa ccgtagatgg 26460 gacaccactg gaaccagggc cggtaagtcc aagcagccgc cgccgttagc ccaagagcaa 26520 caacagcgcc aaggctaccg ctcatggcgc gggcacaaga acgccatagt tgcttgcttg 26580 caagactgtg ggggcaacat ctccttcgcc cgccgctttc ttctctacca tcacggcgtg 26640 gccttccccc gtaacatcct gcattactac cgtcatctct acagcccata ctgcaccggc 26700 ggcagcggca gcggcagcaa cagcagcggc cacacagaag caaaggcgac cggatagcaa 26760 gactctgaca aagcccaaga aatccacagc ggcggcagca gcaggaggag gagcgctgcg 26820 tctggcgccc aacgaacccg tatcgacccg cgagcttaga aacaggattt ttcccactct 26880 gtatgctata tttcaacaga gcaggggcca agaacaagag ctgaaaataa aaaacaggtc 26940 tctgcgatcc ctcacccgca gctgcctgta tcacaaaagc gaagatcagc ttcggcgcac 27000 gctggaagac gcggaggctc tcttcagtaa atactgcgcg ctgactctta aggactagtt 27060 tcgcgccctt tctcaaattt aagcgcgaaa actacgtcat ctccagcggc cacacccggc 27120 gccagcacct gtcgtcagcg ccatttatga gcaaggaaat tcccacgccc tacatgtgga 27180 gttaccagcc acaaatggga cttgcggctg gagctgccca agactactca acccgaataa 27240 actacatgag cgcgggaccc cacatgatat cccgggtcaa cggaatacgc gcccaccgaa 27300 accgaattct cctggaacag gcggctatta ccaccacacc tcgtaataac cttaatcccc 27360 gtagttggcc cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc 27420 ccagagacgc ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct 27480 ttcgtcacag ggtgcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag 27540 gtattcagct caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat 27600 ttcagatcgg cggcgccggc cgctcttcat tcacgcctcg tcaggcaatc ctaactctgc 27660 agacctcgtc ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt 27720 ttgtgccatc ggtctacttt aaccccttct cgggacctcc cggccactat ccggatcaat 27780 ttattcctaa ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg 27840 gagaggcaga gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg 27900 cccgcgactc cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg 27960 cgcacggcgt ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta 28020 cccagcgccc cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca 28080 actgtcctaa ccctggatta catcaagatc tttgttgcca tctctgtgct gagtataata 28140 aatacagaaa ttaaaatata ctggggctcc tatcgccatc ctgtaaacgc caccgtcttc 28200 acccgcccaa gcaaaccaag gcgaacctta cctggtactt ttaacatctc tccctctgtg 28260 atttacaaca gtttcaaccc agacggagtg agtctacgag agaacctctc cgagctcagc 28320 tactccatca gaaaaaacac caccctcctt acctgccggg aacgtacgag tgcgtcaccg 28380 gccgctgcac cacacctacc gcctgaccgt aaaccagact ttttccggac agacctcaat 28440 aactctgttt accagaacag gaggtgagct tagaaaaccc ttagggtatt aggccaaagg 28500 cgcagctact gtggggttta tgaacaattc aagcaactct acgggctatt ctaattcagg 28560 tttctctaga atcggggttg gggttattct ctgtcttgtg attctcttta ttcttatact 28620 aacgcttctc tgcctaaggc tcgccgcctg ctgtgtgcac atttgcattt attgtcagct 28680 ttttaaacgc tggggtcgcc acccaagatg attaggtaca taatcctagg tttactcacc 28740 cttgcgtcag cccacggtac cacccaaaag gtggatttta aggagccagc ctgtaatgtt 28800 acattcgcag ctgaagctaa tgagtgcacc actcttataa aatgcaccac agaacatgaa 28860 aagctgctta ttcgccacaa aaacaaaatt ggcaagtatg ctgtttatgc tatttggcag 28920 ccaggtgaca ctacagagta taatgttaca gttttccagg gtaaaagtca taaaactttt 28980 atgtatactt ttccatttta tgaaatgtgc gacattacca tgtacatgag caaacagtat 29040 aagttgtggc ccccacaaaa ttgtgtggaa aacactggca ctttctgctg cactgctatg 29100 ctaattacag tgctcgcttt ggtctgtacc ctactctata ttaaatacaa aagcagacgc 29160 agctttattg aggaaaagaa aatgccttaa tttactaagt tacaaagcta atgtcaccac 29220 taactgcttt actcgctgct tgcaaaacaa attcaaaaag ttagcattat aattagaata 29280 ggatttaaac cccccggtca tttcctgctc aataccattc ccctgaacaa ttgactctat 29340 gtgggatatg ctccagcgct acaaccttga agtcaggctt cctggatgtc agcatctgac 29400 tttggccagc acctgtcccg cggatttgtt ccagtccaac tacagcgacc caccctaaca 29460 gagatgacca acacaaccaa cgcggccgcc gctaccggac ttacatctac cacaaataca 29520 ccccaagttt ctgcctttgt caataactgg gataacttgg gcatgtggtg gttctccata 29580 gcgcttatgt ttgtatgcct tattattatg tggctcatct gctgcctaaa gcgcaaacgc 29640 gcccgaccac ccatctatag tcccatcatt gtgctacacc caaacaatga tggaatccat 29700 agattggacg gactgaaaca catgttcttt tctcttacag tatgattaaa tgagacatga 29760 ttcctcgagt ttttatatta ctgacccttg ttgcgctttt ttgtgcgtgc tccacattgg 29820 ctgcggtttc tcacatcgaa gtagactgca ttccagcctt cacagtctat ttgctttacg 29880 gatttgtcac cctcacgctc atctgcagcc tcatcactgt ggtcatcgcc tttatccagt 29940 gcattgactg ggtctgtgtg cgctttgcat atctcagaca ccatccccag tacagggaca 30000 ggactatagc tgagcttctt agaattcttt aattatgaaa tttactgtga cttttctgct 30060 gattatttgc accctatctg cgttttgttc cccgacctcc aagcctcaaa gacatatatc 30120 atgcagattc actcgtatat ggaatattcc aagttgctac aatgaaaaaa gcgatctttc 30180 cgaagcctgg ttatatgcaa tcatctctgt tatggtgttc tgcagtacca tcttagccct 30240 agctatatat ccctaccttg acattggctg gaacgcaata gatgccatga accacccaac 30300 tttccccgcg cccgctatgc ttccactgca acaagttgtt gccggcggct ttgtcccagc 30360 caatcagcct cgcccacctt ctcccacccc cactgaaatc agctacttta atctaacagg 30420 aggagatgac tgacacccta gatctagaaa tggacggaat tattacagag cagcgcctgc 30480 tagaaagacg cagggcagcg gccgagcaac agcgcatgaa tcaagagctc caagacatgg 30540 ttaacttgca ccagtgcaaa aggggtatct tttgtctggt aaagcaggcc aaagtcacct 30600 acgacagtaa taccaccgga caccgcctta gctacaagtt gccaaccaag cgtcagaaat 30660 tggtggtcat ggtgggagaa aagcccatta ccataactca gcactcggta gaaaccgaag 30720 gctgcattca ctcaccttgt caaggacctg aggatctctg cacccttatt aagaccctgt 30780 gcggtctcaa agatcttatt ccctttaact aataaaaaaa aataataaag catcacttac 30840 ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc 30900 cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg 30960 tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag 31020 cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt 31080 cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt 31140 ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt 31200 gcgctcaaaa tgggcaacgg cctctctctg gacgaggccg gcaaccttac ctcccaaaat 31260 gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct 31320 gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc 31380 gcgggcaaca cactcaccat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt 31440 agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca 31500 ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact 31560 actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa 31620 ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac tttgaccgta 31680 gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc 31740 ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat 31800 tctcaaaaca gacgccttat acttgatgtt agttatccgt ttgatgctca aaaccaacta 31860 aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac 31920 tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac 31980 ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat 32040 gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc 32100 catggcctag aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt 32160 tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg 32220 accacaccag ctccatctcc taactgtaga ctaaatgcag agaaagatgc taaactcact 32280 ttggtcttaa caaaatgtgg cagtcaaata cttgctacag tttcagtttt ggctgttaaa 32340 ggcagtttgg ctccaatatc tggaacagtt caaagtgctc atcttattat aagatttgac 32400 gaaaatggag tgctactaaa caattccttc ctggacccag aatattggaa ctttagaaat 32460 ggagatctta ctgaaggcac agcctataca aacgctgttg gatttatgcc taacctatca 32520 gcttatccaa aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca agtttactta 32580 aacggagaca aaactaaacc tgtaacacta accattacac taaacggtac acaggaaaca 32640 ggagacacaa ctccaagtgc atactctatg tcattttcat gggactggtc tggccacaac 32700 tacattaatg aaatatttgc cacatcctct tacacttttt catacattgc ccaagaataa 32760 agaatcgttt gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcgaatca 32820 tttttcattc agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa 32880 tcaaacctac atgggggtag agtcataatc gtgcatcagg atagggcggt ggtgctgcag 32940 cagcgcgcga ataaactgct gccgccgccg ctccgtcctg caggaataca acatggcagt 33000 ggtctcctca gcgatgattc gcaccgcccg cagcataagg cgccttgtcc tccgggcaca 33060 gcagcgcacc ctgatctcac ttaaatcagc acagtaactg cagcacagca ccacaatatt 33120 gttcaaaatc ccacagtgca aggcgctgta tccaaagctc atggcgggga ccacagaacc 33180 cacgtggcca tcataccaca agcgcaggta gattaagtgg cgacccctca taaacacgct 33240 ggacataaac attacctctt ttggcatgtt gtaattcacc acctcccggt accatataaa 33300 cctctgatta aacatggcgc catccaccac catcctaaac cagctggcca aaacctgccc 33360 gccggctata cactgcaggg aaccgggact ggaacaatga cagtggagag cccaggactc 33420 gtaaccatgg atcatcatgc tcgtcatgat atcaatgttg gcacaacaca ggcacacgtg 33480 catacacttc ctcaggatta caagctcctc ccgcgttaga accatatccc agggaacaac 33540 ccattcctga atcagcgtaa atcccacact gcagggaaga cctcgcacgt aactcacgtt 33600 gtgcattgtc aaagtgttac attcgggcag cagcggatga tcctccagta tggtagcgcg 33660 ggtttctgtc tcaaaaggag gtagacgatc cctactgtac ggagtgcgcc gagacaaccg 33720 agatcgtgtt ggtcgtagtg tcatgccaaa tggaacgccg gacgtagtca tatttcctga 33780 agcaaaacca ggtgcgggcg tgacaaacag atctgcgtct ccggtctcgc cgcttagatc 33840 gctctgtgta gtagttgtag tatatccact ctctcaaagc atccaggcgc cccctggctt 33900 cgggttctat gtaaactcct tcatgcgccg ctgccctgat aacatccacc accgcagaat 33960 aagccacacc cagccaacct acacattcgt tctgcgagtc acacacggga ggagcgggaa 34020 gagctggaag aaccatgttt ttttttttat tccaaaagat tatccaaaac ctcaaaatga 34080 agatctatta agtgaacgcg ctcccctccg gtggcgtggt caaactctac agccaaagaa 34140 cagataatgg catttgtaag atgttgcaca atggcttcca aaaggcaaac ggccctcacg 34200 tccaagtgga cgtaaaggct aaacccttca gggtgaatct cctctataaa cattccagca 34260 ccttcaacca tgcccaaata attctcatct cgccaccttc tcaatatatc tctaagcaaa 34320 tcccgaatat taagtccggc cattgtaaaa atctgctcca gagcgccctc caccttcagc 34380 ctcaagcagc gaatcatgat tgcaaaaatt caggttcctc acagacctgt ataagattca 34440 aaagcggaac attaacaaaa ataccgcgat cccgtaggtc ccttcgcagg gccagctgaa 34500 cataatcgtg caggtctgca cggaccagcg cggccacttc cccgccagga accatgacaa 34560 aagaacccac actgattatg acacgcatac tcggagctat gctaaccagc gtagccccga 34620 tgtaagcttg ttgcatgggc ggcgatataa aatgcaaggt gctgctcaaa aaatcaggca 34680 aagcctcgcg caaaaaagaa agcacatcgt agtcatgctc atgcagataa aggcaggtaa 34740 gctccggaac caccacagaa aaagacacca tttttctctc aaacatgtct gcgggtttct 34800 gcataaacac aaaataaaat aacaaaaaaa catttaaaca ttagaagcct gtcttacaac 34860 aggaaaaaca acccttataa gcataagacg gactacggcc atgccggcgt gaccgtaaaa 34920 aaactggtca ccgtgattaa aaagcaccac cgacagctcc tcggtcatgt ccggagtcat 34980 aatgtaagac tcggtaaaca catcaggttg attcacatcg gtcagtgcta aaaagcgacc 35040 gaaatagccc gggggaatac atacccgcag gcgtagagac aacattacag cccccatagg 35100 aggtataaca aaattaatag gagagaaaaa cacataaaca cctgaaaaac cctcctgcct 35160 aggcaaaata gcaccctccc gctccagaac aacatacagc gcttccacag cggcagccat 35220 aacagtcagc cttaccagta aaaaagaaaa cctattaaaa aaacaccact cgacacggca 35280 ccagctcaat cagtcacagt gtaaaaaagg gccaagtgca gagcgagtat atataggact 35340 aaaaaatgac gtaacggtta aagtccacaa aaaacaccca gaaaaccgca cgcgaaccta 35400 cgcccagaaa cgaaagccaa aaaacccaca acttcctcaa atcgtcactt ccgttttccc 35460 acgttacgtc acttcccatt ttaagaaaac tacaattccc aacacataca agttactccg 35520 ccctaaaacc tacgtcaccc gccccgttcc cacgccccgc gccacgtcac aaactccacc 35580 ccctcattat catattggct tcaatccaaa ataaggtata ttattgatga tg 35632 <210> 15 <211> 35623 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO291) <400> 15 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgaccgaaga aatggccgcc agtcttttgg accagctgat 600 cgaagaggta ctggctgata atcttccacc tcctagccat tttgaaccac ctacccttca 660 cgaactgtat gatttagacg tgacggcccc cgaagatccc aacgaggagg cggtttcgca 720 gatttttccc gactctgtaa tgttggcggt gcaggaaggg attgacttac tcacttttcc 780 gccggcgccc ggttctccgg agccgcctca cctttcccgg cagcccgagc agccggagca 840 gagagccttg ggtccggttt ctatgccaaa ccttgtaccg gaggtgatcg atcttacctg 900 ccacgaggct ggctttccac ccagtgacga cgaggatgaa gagggtgagg agtttgtgtt 960 agattatgtg gagcaccccg ggcacggttg caggtcttgt cattatcacc ggaggaatac 1020 gggggaccca gatattatgt gttcgctttg ctatatgagg acctgtggca tgtttgtcta 1080 cagtaagtga aaattatggg cagtgggtga tagagtggtg ggtttggtgt ggtaattttt 1140 tttttaattt ttacagtttt gtggtttaaa gaattttgta ttgtgatttt tttaaaaggt 1200 cctgtgtctg aacctgagcc tgagcccgag ccagaaccgg agcctgcaag acctacccgc 1260 cgtcctaaaa tggcgcctgc tatcctgaga cgcccgacat cacctgtgtc tagagaatgc 1320 aatagtagta cggatagctg tgactccggt ccttctaaca cacctcctga gatacacccg 1380 gtggtcccgc tgtgccccat taaaccagtt gccgtgagag ttggtgggcg tcgccaggct 1440 gtggaatgta tcgaggactt gcttaacgag cctgggcaac ctttggactt gagctgtaaa 1500 cgccccaggc cataaggtgt aaacctgtga ttgcgtgtgt ggttaacgcc tttgtttgct 1560 gaatgagttg atgtaagttt aataaagggt gagataatgt ttaacttgca tggcgtgtta 1620 aatggggcgg ggcttaaagg gtatataatg cgccgtgggc taatcttggt tacatctgac 1680 ctcatggagg cttgggagtg tttggaagat ttttctgctg tgcgtaactt gctggaacag 1740 agctctaaca gtacctcttg gttttggagg tttctgtggg gctcatccca ggcaaagtta 1800 gtctgcagaa ttaaggagga ttacaagtgg gaatttgaag agcttttgaa atcctgtggt 1860 gagctgtttg attctttgaa tctgggtcac caggcgcttt tccaagagaa ggtcatcaag 1920 actttggatt tttccacacc ggggcgcgct gcggctgctg ttgctttttt gagttttata 1980 aaggataaat ggagcgaaga aacccatctg agcggggggt acctgctgga ttttctggcc 2040 atgcatctgt ggagagcggt tgtgagacac aagaatcgcc tgctactgtt gtcttccgtc 2100 cgcccggcga taataccgac ggaggagcag cagcagcagc aggaggaagc caggcggcgg 2160 cggcaggagc agagcccatg gaacccgaga gccggcctgg accctcggga atgaatgttg 2220 tacaggtggc tgaactgtat ccagaactga gacgcatttt gacaattaca gaggatgggc 2280 aggggctaaa gggggtaaag agggagcggg gggcttgtga ggctacagag gaggctagga 2340 atctagcttt tagcttaatg accagacacc gtcctgagtg tattactttt caacagatca 2400 aggataattg cgctaatgag cttgatctgc tggcgcagaa gtattccata gagcagctga 2460 ccacttactg gctgcagcca ggggatgatt ttgaggaggc tattagggta tatgcaaagg 2520 tggcacttag gccagattgc aagtacaaga tcagcaaact tgtaaatatc aggaattgtt 2580 gctacatttc tgggaacggg gccgaggtgg agatagatac ggaggatagg gtggccttta 2640 gatgtagcat gataaatatg tggccggggg tgcttggcat ggacggggtg gttattatga 2700 atgtaaggtt tactggcccc aattttagcg gtacggtttt cctggccaat accaacctta 2760 tcctacacgg tgtaagcttc tatgggttta acaatacctg tgtggaagcc tggaccgatg 2820 taagggttcg gggctgtgcc ttttactgct gctggaaggg ggtggtgtgt cgccccaaaa 2880 gcagggcttc aattaagaaa tgcctctttg aaaggtgtac cttgggtatc ctgtctgagg 2940 gtaactccag ggtgcgccac aatgtggcct ccgactgtgg ttgcttcatg ctagtgaaaa 3000 gcgtggctgt gattaagcat aacatggtat gtggcaactg cgaggacagg gcctctcaga 3060 tgctgacctg ctcggacggc aactgtcacc tgctgaagac cattcacgta gccagccact 3120 ctcgcaaggc ctggccagtg tttgagcata acatactgac ccgctgttcc ttgcatttgg 3180 gtaacaggag gggggtgttc ctaccttacc aatgcaattt gagtcacact aagatattgc 3240 ttgagcccga gagcatgtcc aaggtgaacc tgaacggggt gtttgacatg accatgaaga 3300 tctggaaggt gctgaggtac gatgagaccc gcaccaggtg cagaccctgc gagtgtggcg 3360 gtaaacatat taggaaccag cctgtgatgc tggatgtgac cgaggagctg aggcccgatc 3420 acttggtgct ggcctgcacc cgcgctgagt ttggctctag cgatgaagat acagattgag 3480 gtactgaaat gtgtgggcgt ggcttaaggg tgggaaagaa tatataaggt gggggtctta 3540 tgtagttttg tatctgtttt gcagcagccg ccgccgccat gagcaccaac tcgtttgatg 3600 gaagcattgt gagctcatat ttgacaacgc gcatgccccc atgggccggg gtgcgtcaga 3660 atgtgatggg ctccagcatt gatggtcgcc ccgtcctgcc cgcaaactct actaccttga 3720 cctacgagac cgtgtctgga acgccgttgg agactgcagc ctccgccgcc gcttcagccg 3780 ctgcagccac cgcccgcggg attgtgactg actttgcttt cctgagcccg cttgcaagca 3840 gtgcagcttc ccgttcatcc gcccgcgatg acaagttgac ggctcttttg gcacaattgg 3900 attctttgac ccgggaactt aatgtcgttt ctcagcagct gttggatctg cgccagcagg 3960 tttctgccct gaaggcttcc tcccctccca atgcggttta aaacataaat aaaaaaccag 4020 actctgtttg gatttggatc aagcataagt gtcttgctgt ctttatttag gggttttgcg 4080 cgcgcggtag gcccgggacc agcggtctcg gtcgttgagg gtcctgtgta ttttttccag 4140 gacgtggtaa aggtgactct ggatgttcag atacatgggc ataagcccgt ctctggggtg 4200 gaggtagcac cactgcagag cttcatgctg cggggtggtg ttgtagatga tccagtcgta 4260 gcaggagcgc tgggcgtggt gcctaaaaat gtctttcagt agcaagctga ttgccagggg 4320 caggcccttg gtgtaagtgt ttacaaagcg gttaagctgg gatgggtgca tacgtgggga 4380 tatgagatgc atcttggact gtatttttag gttggctatg ttcccagcca tatccctccg 4440 gggattcatg ttgtgcagaa ccaccagcac agtgtatccg gtgcacttgg gaaatttgtc 4500 atgtagctta gaaggaaatg cgtggaagaa cttggagacg cccttgtgac ctccaagatt 4560 ttccatgcat tcgtccataa tgatggcaat gggcccacgg gcggcggcct gggcgaagat 4620 atttctggga tcactaacgt catagttgtg ttccaggatg agatcgtcat aggccatttt 4680 tacaaagcgc gggcggaggg tgccagactg cggtataatg gttccatccg gcccaggggc 4740 gtagttaccc tcacagattt gcatttccca cgctttgagt tcagatgggg ggatcatgtc 4800 tacctgcggg gcgatgaaga aaacggtttc cggggtaggg gagatcagct gggaagaaag 4860 caggttcctg agcagctgcg acttaccgca gccggtgggc ccgtaaatca cacctattac 4920 cgggtgcaac tggtagttaa gagagctgca gctgccgtca tccctgagca ggggggccac 4980 ttcgttaagc atgtccctga ctcgcatgtt ttccctgacc aaatccgcca gaaggcgctc 5040 gccgcccagc gatagcagtt cttgcaagga agcaaagttt ttcaacggtt tgagaccgtc 5100 cgccgtaggc atgcttttga gcgtttgacc aagcagttcc aggcggtccc acagctcggt 5160 cacctgctct acggcatctc gatccagcat atctcctcgt ttcgcgggtt ggggcggctt 5220 tcgctgtacg gcagtagtcg gtgctcgtcc agacgggcca gggtcatgtc tttccacggg 5280 cgcagggtcc tcgtcagcgt agtctgggtc acggtgaagg ggtgcgctcc gggctgcgcg 5340 ctggccaggg tgcgcttgag gctggtcctg ctggtgctga agcgctgccg gtcttcgccc 5400 tgcgcgtcgg ccaggtagca tttgaccatg gtgtcatagt ccagcccctc cgcggcgtgg 5460 cccttggcgc gcagcttgcc cttggaggag gcgccgcacg aggggcagtg cagacttttg 5520 agggcgtaga gcttgggcgc gagaaatacc gattccgggg agtaggcatc cgcgccgcag 5580 gccccgcaga cggtctcgca ttccacgagc caggtgagct ctggccgttc ggggtcaaaa 5640 accaggtttc ccccatgctt tttgatgcgt ttcttacctc tggtttccat gagccggtgt 5700 ccacgctcgg tgacgaaaag gctgtccgtg tccccgtata cagacttgag aggcctgtcc 5760 tcgagcggtg ttccgcggtc ctcctcgtat agaaactcgg accactctga gacaaaggct 5820 cgcgtccagg ccagcacgaa ggaggctaag tgggaggggt agcggtcgtt gtccactagg 5880 gggtccactc gctccagggt gtgaagacac atgtcgccct cttcggcatc aaggaaggtg 5940 attggtttgt aggtgtaggc cacgtgaccg ggtgttcctg aaggggggct ataaaagggg 6000 gtgggggcgc gttcgtcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg 6060 ggtgagtact ccctctgaaa agcgggcatg acttctgcgc taagattgtc agtttccaaa 6120 aacgaggagg atttgatatt cacctggccc gcggtgatgc ctttgagggt ggccgcatcc 6180 atctggtcag aaaagacaat ctttttgttg tcaagcttgg tggcaaacga cccgtagagg 6240 gcgttggaca gcaacttggc gatggagcgc agggtttggt ttttgtcgcg atcggcgcgc 6300 tccttggccg cgatgtttag ctgcacgtat tcgcgcgcaa cgcaccgcca ttcgggaaag 6360 acggtggtgc gctcgtcggg caccaggtgc acgcgccaac cgcggttgtg cagggtgaca 6420 aggtcaacgc tggtggctac ctctccgcgt aggcgctcgt tggtccagca gaggcggccg 6480 cccttgcgcg agcagaatgg cggtaggggg tctagctgcg tctcgtccgg ggggtctgcg 6540 tccacggtaa agaccccggg cagcaggcgc gcgtcgaagt agtctatctt gcatccttgc 6600 aagtctagcg cctgctgcca tgcgcgggcg gcaagcgcgc gctcgtatgg gttgagtggg 6660 ggaccccatg gcatggggtg ggtgagcgcg gaggcgtaca tgccgcaaat gtcgtaaacg 6720 tagaggggct ctctgagtat tccaagatat gtagggtagc atcttccacc gcggatgctg 6780 gcgcgcacgt aatcgtatag ttcgtgcgag ggagcgagga ggtcgggacc gaggttgcta 6840 cgggcgggct gctctgctcg gaagactatc tgcctgaaga tggcatgtga gttggatgat 6900 atggttggac gctggaagac gttgaagctg gcgtctgtga gacctaccgc gtcacgcacg 6960 aaggaggcgt aggagtcgcg cagcttgttg accagctcgg cggtgacctg cacgtctagg 7020 gcgcagtagt ccagggtttc cttgatgatg tcatacttat cctgtccctt ttttttccac 7080 agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt actcttggat cggaaacccg 7140 tcggcctccg aacggtaaga gcctagcatg tagaactggt tgacggcctg gtaggcgcag 7200 catccctttt ctacgggtag cgcgtatgcc tgcgcggcct tccggagcga ggtgtgggtg 7260 agcgcaaagg tgtccctgac catgactttg aggtactggt atttgaagtc agtgtcgtcg 7320 catccgccct gctcccagag caaaaagtcc gtgcgctttt tggaacgcgg atttggcagg 7380 gcgaaggtga catcgttgaa gagtatcttt cccgcgcgag gcataaagtt gcgtgtgatg 7440 cggaagggtc ccggcacctc ggaacggttg ttaattacct gggcggcgag cacgatctcg 7500 tcaaagccgt tgatgttgtg gcccacaatg taaagttcca agaagcgcgg gatgcccttg 7560 atggaaggca attttttaag ttcctcgtag gtgagctctt caggggagct gagcccgtgc 7620 tctgaaaggg cccagtctgc aagatgaggg ttggaagcga cgaatgagct ccacaggtca 7680 cgggccatta gcatttgcag gtggtcgcga aaggtcctaa actggcgacc tatggccatt 7740 ttttctgggg tgatgcagta gaaggtaagc gggtcttgtt cccagcggtc ccatccaagg 7800 ttcgcggcta ggtctcgcgc ggcagtcact agaggctcat ctccgccgaa cttcatgacc 7860 agcatgaagg gcacgagctg cttcccaaag gcccccatcc aagtataggt ctctacatcg 7920 taggtgacaa agagacgctc ggtgcgagga tgcgagccga tcgggaagaa ctggatctcc 7980 cgccaccaat tggaggagtg gctattgatg tggtgaaagt agaagtccct gcgacgggcc 8040 gaacactcgt gctggctttt gtaaaaacgt gcgcagtact ggcagcggtg cacgggctgt 8100 acatcctgca cgaggttgac ctgacgaccg cgcacaagga agcagagtgg gaatttgagc 8160 ccctcgcctg gcgggtttgg ctggtggtct tctacttcgg ctgcttgtcc ttgaccgtct 8220 ggctgctcga ggggagttac ggtggatcgg accaccacgc cgcgcgagcc caaagtccag 8280 atgtccgcgc gcggcggtcg gagcttgatg acaacatcgc gcagatggga gctgtccatg 8340 gtctggagct cccgcggcgt caggtcaggc gggagctcct gcaggtttac ctcgcataga 8400 cgggtcaggg cgcgggctag atccaggtga tacctaattt ccaggggctg gttggtggcg 8460 gcgtcgatgg cttgcaagag gccgcatccc cgcggcgcga ctacggtacc gcgcggcggg 8520 cggtgggccg cgggggtgtc cttggatgat gcatctaaaa gcggtgacgc gggcgagccc 8580 ccggaggtag ggggggctcc ggacccgccg ggagaggggg caggggcacg tcggcgccgc 8640 gcgcgggcag gagctggtgc tgcgcgcgta ggttgctggc gaacgcgacg acgcggcggt 8700 tgatctcctg aatctggcgc ctctgcgtga agacgacggg cccggtgagc ttgagcctga 8760 aagagagttc gacagaatca atttcggtgt cgttgacggc ggcctggcgc aaaatctcct 8820 gcacgtctcc tgagttgtct tgataggcga tctcggccat gaactgctcg atctcttcct 8880 cctggagatc tccgcgtccg gctcgctcca cggtggcggc gaggtcgttg gaaatgcggg 8940 ccatgagctg cgagaaggcg ttgaggcctc cctcgttcca gacgcggctg tagaccacgc 9000 ccccttcggc atcgcgggcg cgcatgacca cctgcgcgag attgagctcc acgtgccggg 9060 cgaagacggc gtagtttcgc aggcgctgaa agaggtagtt gagggtggtg gcggtgtgtt 9120 ctgccacgaa gaagtacata acccagcgtc gcaacgtgga ttcgttgata tcccccaagg 9180 cctcaaggcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc 9240 gcgccgacac ggttaactcc tcctccagaa gacggatgag ctcggcgaca gtgtcgcgca 9300 cctcgcgctc aaaggctaca ggggcctctt cttcttcttc aatctcctct tccataaggg 9360 cctccccttc ttcttcttct ggcggcggtg ggggaggggg gacacggcgg cgacgacggc 9420 gcaccgggag gcggtcgaca aagcgctcga tcatctcccc gcggcgacgg cgcatggtct 9480 cggtgacggc gcggccgttc tcgcgggggc gcagttggaa gacgccgccc gtcatgtccc 9540 ggttatgggt tggcgggggg ctgccatgcg gcagggatac ggcgctaacg atgcatctca 9600 acaattgttg tgtaggtact ccgccgccga gggacctgag cgagtccgca tcgaccggat 9660 cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc gcaaggtagg ctgagcaccg 9720 tggcgggcgg cagcgggcgg cggtcggggt tgtttctggc ggaggtgctg ctgatgatgt 9780 aattaaagta ggcggtcttg agacggcgga tggtcgacag aagcaccatg tccttgggtc 9840 cggcctgctg aatgcgcagg cggtcggcca tgccccaggc ttcgttttga catcggcgca 9900 ggtctttgta gtagtcttgc atgagccttt ctaccggcac ttcttcttct ccttcctctt 9960 gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga gtttggccgt aggtggcgcc 10020 ctcttcctcc catgcgtgtg accccgaagc ccctcatcgg ctgaagcagg gctaggtcgg 10080 cgacaacgcg ctcggctaat atggcctgct gcacctgcgt gagggtagac tggaagtcat 10140 ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt gtaagtgcag ttggccataa 10200 cggaccagtt aacggtctgg tgacccggct gcgagagctc ggtgtacctg agacgcgagt 10260 aagccctcga gtcaaatacg tagtcgttgc aagtccgcac caggtactgg tatcccacca 10320 aaaagtgcgg cggcggctgg cggtagaggg gccagcgtag ggtggccggg gctccggggg 10380 cgagatcttc caacataagg cgatgatatc cgtagatgta cctggacatc caggtgatgc 10440 cggcggcggt ggtggaggcg cgcggaaagt cgcggacgcg gttccagatg ttgcgcagcg 10500 gcaaaaagtg ctccatggtc gggacgctct ggccggtcag gcgcgcgcaa tcgttgacgc 10560 tctagaccgt gcaaaaggag agcctgtaag cgggcactct tccgtggtct ggtggataaa 10620 ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc cgtatccggc cgtccgccgt 10680 gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga caacggggga 10740 gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc gctagctttt ttggccactg 10800 gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc tcgctccctg 10860 tagccggagg gttattttcc aagggttgag tcgcgggacc cccggttcga gtctcggacc 10920 ggccggactg cggcgaacgg gggtttgcct ccccgtcatg caagaccccg cttgcaaatt 10980 cctccggaaa cagggacgag cccctttttt gcttttccca gatgcatccg gtgctgcggc 11040 agatgcgccc ccctcctcag cagcggcaag agcaagagca gcggcagaca tgcagggcac 11100 cctcccctcc tcctaccgcg tcaggagggg cgacatccgc ggttgacgcg gcagcagatg 11160 gtgattacga acccccgcgg cgccgggccc ggcactacct ggacttggag gagggcgagg 11220 gcctggcgcg gctaggagcg ccctctcctg agcggtaccc aagggtgcag ctgaagcgtg 11280 atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg cgaccgcgag ggagaggagc 11340 ccgaggagat gcgggatcga aagttccacg cagggcgcga gctgcggcat ggcctgaatc 11400 gcgagcggtt gctgcgcgag gaggactttg agcccgacgc gcgaaccggg attagtcccg 11460 cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata cgagcagacg gtgaaccagg 11520 agattaactt tcaaaaaagc tttaacaacc acgtgcgtac gcttgtggcg cgcgaggagg 11580 tggctatagg actgatgcat ctgtgggact ttgtaagcgc gctggagcaa aacccaaata 11640 gcaagccgct catggcgcag ctgttcctta tagtgcagca cagcagggac aacgaggcat 11700 tcagggatgc gctgctaaac atagtagagc ccgagggccg ctggctgctc gatttgataa 11760 acatcctgca gagcatagtg gtgcaggagc gcagcttgag cctggctgac aaggtggccg 11820 ccatcaacta ttccatgctt agcctgggca agttttacgc ccgcaagata taccataccc 11880 cttacgttcc catagacaag gaggtaaaga tcgaggggtt ctacatgcgc atggcgctga 11940 aggtgcttac cttgagcgac gacctgggcg tttatcgcaa cgagcgcatc cacaaggccg 12000 tgagcgtgag ccggcggcgc gagctcagcg accgcgagct gatgcacagc ctgcaaaggg 12060 ccctggctgg cacgggcagc ggcgatagag aggccgagtc ctactttgac gcgggcgctg 12120 acctgcgctg ggccccaagc cgacgcgccc tggaggcagc tggggccgga cctgggctgg 12180 cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga ggaatatgac gaggacgatg 12240 agtacgagcc agaggacggc gagtactaag cggtgatgtt tctgatcaga tgatgcaaga 12300 cgcaacggac ccggcggtgc gggcggcgct gcagagccag ccgtccggcc ttaactccac 12360 ggacgactgg cgccaggtca tggaccgcat catgtcgctg actgcgcgca atcctgacgc 12420 gttccggcag cagccgcagg ccaaccggct ctccgcaatt ctggaagcgg tggtcccggc 12480 gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta aacgcgctgg ccgaaaacag 12540 ggccatccgg cccgacgagg ccggcctggt ctacgacgcg ctgcttcagc gcgtggctcg 12600 ttacaacagc ggcaacgtgc agaccaacct ggaccggctg gtgggggatg tgcgcgaggc 12660 cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg ggctccatgg ttgcactaaa 12720 cgccttcctg agtacacagc ccgccaacgt gccgcgggga caggaggact acaccaactt 12780 tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa agtgaggtgt accagtctgg 12840 gccagactat tttttccaga ccagtagaca aggcctgcag accgtaaacc tgagccaggc 12900 tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc acaggcgacc gcgcgaccgt 12960 gtctagcttg ctgacgccca actcgcgcct gttgctgctg ctaatagcgc ccttcacgga 13020 cagtggcagc gtgtcccggg acacatacct aggtcacttg ctgacactgt accgcgaggc 13080 cataggtcag gcgcatgtgg acgagcatac tttccaggag attacaagtg tcagccgcgc 13140 gctggggcag gaggacacgg gcagcctgga ggcaacccta aactacctgc tgaccaaccg 13200 gcggcagaag atcccctcgt tgcacagttt aaacagcgag gaggagcgca ttttgcgcta 13260 cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg gtaacgccca gcgtggcgct 13320 ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc tcaaaccggc cgtttatcaa 13380 ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac cccgagtatt tcaccaatgc 13440 catcttgaac ccgcactggc taccgccccc tggtttctac accgggggat tcgaggtgcc 13500 cgagggtaac gatggattcc tctgggacga catagacgac agcgtgtttt ccccgcaacc 13560 gcagaccctg ctagagttgc aacagcgcga gcaggcagag gcggcgctgc gaaaggaaag 13620 cttccgcagg ccaagcagct tgtccgatct aggcgctgcg gccccgcggt cagatgctag 13680 tagcccattt ccaagcttga tagggtctct taccagcact cgcaccaccc gcccgcgcct 13740 gctgggcgag gaggagtacc taaacaactc gctgctgcag ccgcagcgcg aaaaaaacct 13800 gcctccggca tttcccaaca acgggataga gagcctagtg gacaagatga gtagatggaa 13860 gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc ccgcccaccc gtcgtcaaag 13920 gcacgaccgt cagcggggtc tggtgtggga ggacgatgac tcggcagacg acagcagcgt 13980 cctggatttg ggagggagtg gcaacccgtt tgcgcacctt cgccccaggc tggggagaat 14040 gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc accaaggcca tggcaccgag 14100 cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg cgatgtatga ggaaggtcct 14160 cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg cggcggcgct gggttctccc 14220 ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt acctgcggcc taccgggggg 14280 agaaacagca tccgttactc tgagttggca cccctattcg acaccacccg tgtgtacctg 14340 gtggacaaca agtcaacgga tgtggcatcc ctgaactacc agaacgacca cagcaacttt 14400 ctgaccacgg tcattcaaaa caatgactac agcccggggg aggcaagcac acagaccatc 14460 aatcttgacg accggtcgca ctggggcggc gacctgaaaa ccatcctgca taccaacatg 14520 ccaaatgtga acgagttcat gtttaccaat aagtttaagg cgcgggtgat ggtgtcgcgc 14580 ttgcctacta aggacaatca ggtggagctg aaatacgagt gggtggagtt cacgctgccc 14640 gagggcaact actccgagac catgaccata gaccttatga acaacgcgat cgtggagcac 14700 tacttgaaag tgggcagaca gaacggggtt ctggaaagcg acatcggggt aaagtttgac 14760 acccgcaact tcagactggg gtttgacccc gtcactggtc ttgtcatgcc tggggtatat 14820 acaaacgaag ccttccatcc agacatcatt ttgctgccag gatgcggggt ggacttcacc 14880 cacagccgcc tgagcaactt gttgggcatc cgcaagcggc aacccttcca ggagggcttt 14940 aggatcacct acgatgatct ggagggtggt aacattcccg cactgttgga tgtggacgcc 15000 taccaggcga gcttgaaaga tgacaccgaa cagggcgggg gtggcgcagg cggcagcaac 15060 agcagtggca gcggcgcgga agagaactcc aacgcggcag ccgcggcaat gcagccggtg 15120 gaggacatga acgatcatgc cattcgcggc gacacctttg ccacacgggc tgaggagaag 15180 cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg ctgcgcaacc cgaggtcgag 15240 aagcctcaga agaaaccggt gatcaaaccc ctgacagagg acagcaagaa acgcagttac 15300 aacctaataa gcaatgacag caccttcacc cagtaccgca gctggtacct tgcatacaac 15360 tacggcgacc ctcagaccgg aatccgctca tggaccctgc tttgcactcc tgacgtaacc 15420 tgcggctcgg agcaggtcta ctggtcgttg ccagacatga tgcaagaccc cgtgaccttc 15480 cgctccacgc gccagatcag caactttccg gtggtgggcg ccgagctgtt gcccgtgcac 15540 tccaagagct tctacaacga ccaggccgtc tactcccaac tcatccgcca gtttacctct 15600 ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc gccagccccc 15660 accatcacca ccgtcagtga aaacgttcct gctctcacag atcacgggac gctaccgctg 15720 cgcaacagca tcggaggagt ccagcgagtg accattactg acgccagacg ccgcacctgc 15780 ccctacgttt acaaggccct gggcatagtc tcgccgcgcg tcctatcgag ccgcactttt 15840 tgagcaagca tgtccatcct tatatcgccc agcaataaca caggctgggg cctgcgcttc 15900 ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc aacacccagt gcgcgtgcgc 15960 gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc gcactgggcg caccaccgtc 16020 gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact acacgcccac gccgccacca 16080 gtgtccacag tggacgcggc cattcagacc gtggtgcgcg gagcccggcg ctatgctaaa 16140 atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc gccgacccgg cactgccgcc 16200 caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca ccggccgacg ggcggccatg 16260 cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc cccccaggtc caggcgacga 16320 gcggccgccg cagcagccgc ggccattagt gctatgactc agggtcgcag gggcaacgtg 16380 tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg tgcgcacccg ccccccgcgc 16440 aactagattg caagaaaaaa ctacttagac tcgtactgtt gtatgtatcc agcggcggcg 16500 gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag agatgctcca ggtcatcgcg 16560 ccggagatct atggcccccc gaagaaggaa gagcaggatt acaagccccg aaagctaaag 16620 cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg acgacgaggt ggaactgctg 16680 cacgctaccg cgcccaggcg acgggtacag tggaaaggtc gacgcgtaaa acgtgttttg 16740 cgacccggca ccaccgtagt ctttacgccc ggtgagcgct ccacccgcac ctacaagcgc 16800 gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc aggccaacga gcgcctcggg 16860 gagtttgcct acggaaagcg gcataaggac atgctggcgt tgccgctgga cgagggcaac 16920 ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc tgcccgcgct tgcaccgtcc 16980 gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg cacccaccgt gcagctgatg 17040 gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa tgaccgtgga acctgggctg 17100 gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc cgggactggg cgtgcagacc 17160 gtggacgttc agatacccac taccagtagc accagtattg ccaccgccac agagggcatg 17220 gagacacaaa cgtccccggt tgcctcagcg gtggcggatg ccgcggtgca ggcggtcgct 17280 gcggccgcgt ccaagacctc tacggaggtg caaacggacc cgtggatgtt tcgcgtttca 17340 gccccccggc gcccgcgcgg ttcgaggaag tacggcgccg ccagcgcgct actgcccgaa 17400 tatgccctac atccttccat tgcgcctacc cccggctatc gtggctacac ctaccgcccc 17460 agaagacgag caactacccg acgccgaacc accactggaa cccgccgccg ccgtcgccgt 17520 cgccagcccg tgctggcccc gatttccgtg cgcagggtgg ctcgcgaagg aggcaggacc 17580 ctggtgctgc caacagcgcg ctaccacccc agcatcgttt aaaagccggt ctttgtggtt 17640 cttgcagata tggccctcac ctgccgcctc cgtttcccgg tgccgggatt ccgaggaaga 17700 atgcaccgta ggaggggcat ggccggccac ggcctgacgg gcggcatgcg tcgtgcgcac 17760 caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg gtatcctgcc cctccttatt 17820 ccactgatcg ccgcggcgat tggcgccgtg cccggaattg catccgtggc cttgcaggcg 17880 cagagacact gattaaaaac aagttgcatg tggaaaaatc aaaataaaaa gtctggactc 17940 tcacgctcgc ttggtcctgt aactattttg tagaatggaa gacatcaact ttgcgtctct 18000 ggccccgcga cacggctcgc gcccgttcat gggaaactgg caagatatcg gcaccagcaa 18060 tatgagcggt ggcgccttca gctggggctc gctgtggagc ggcattaaaa atttcggttc 18120 caccgttaag aactatggca gcaaggcctg gaacagcagc acaggccaga tgctgaggga 18180 taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat ggcctggcct ctggcattag 18240 cggggtggtg gacctggcca accaggcagt gcaaaataag attaacagta agcttgatcc 18300 ccgccctccc gtagaggagc ctccaccggc cgtggagaca gtgtctccag aggggcgtgg 18360 cgaaaagcgt ccgcgccccg acagggaaga aactctggtg acgcaaatag acgagcctcc 18420 ctcgtacgag gaggcactaa agcaaggcct gcccaccacc cgtcccatcg cgcccatggc 18480 taccggagtg ctgggccagc acacacccgt aacgctggac ctgcctcccc ccgccgacac 18540 ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt gtaacccgtc ctagccgcgc 18600 gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg cccgtagcca gtggcaactg 18660 gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa tccctgaagc gccgacgatg 18720 cttctgaata gctaacgtgt cgtatgtgtg tcatgtatgc gtccatgtcg ccgccagagg 18780 agctgctgag ccgccgcgcg cccgctttcc aagatggcta ccccttcgat gatgccgcag 18840 tggtcttaca tgcacatctc gggccaggac gcctcggagt acctgagccc cgggctggtg 18900 cagtttgccc gcgccaccga gacgtacttc agcctgaata acaagtttag aaaccccacg 18960 gtggcgccta cgcacgacgt gaccacagac cggtcccagc gtttgacgct gcggttcatc 19020 cctgtggacc gtgaggatac tgcgtactcg tacaaggcgc ggttcaccct agctgtgggt 19080 gataaccgtg tgctggacat ggcttccacg tactttgaca tccgcggcgt gctggacagg 19140 ggccctactt ttaagcccta ctctggcact gcctacaacg ccctggctcc caagggtgcc 19200 ccaaatcctt gcgaatggga tgaagctgct actgctcttg aaataaacct agaagaagag 19260 gacgatgaca acgaagacga agtagacgag caagctgagc agcaaaaaac tcacgtattt 19320 gggcaggcgc cttattctgg tataaatatt acaaaggagg gtattcaaat aggtgtcgaa 19380 ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg aacctcaaat aggagaatct 19440 cagtggtacg aaactgaaat taatcatgca gctgggagag tccttaaaaa gactacccca 19500 atgaaaccat gttacggttc atatgcaaaa cccacaaatg aaaatggagg gcaaggcatt 19560 cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg aaatgcaatt tttctcaact 19620 actgaggcga ccgcaggcaa tggtgataac ttgactccta aagtggtatt gtacagtgaa 19680 gatgtagata tagaaacccc agacactcat atttcttaca tgcccactat taaggaaggt 19740 aactcacgag aactaatggg ccaacaatct atgcccaaca ggcctaatta cattgctttt 19800 agggacaatt ttattggtct aatgtattac aacagcacgg gtaatatggg tgttctggcg 19860 ggccaagcat cgcagttgaa tgctgttgta gatttgcaag acagaaacac agagctttca 19920 taccagcttt tgcttgattc cattggtgat agaaccaggt acttttctat gtggaatcag 19980 gctgttgaca gctatgatcc agatgttaga attattgaaa atcatggaac tgaagatgaa 20040 cttccaaatt actgctttcc actgggaggt gtgattaata cagagactct taccaaggta 20100 aaacctaaaa caggtcagga aaatggatgg gaaaaagatg ctacagaatt ttcagataaa 20160 aatgaaataa gagttggaaa taattttgcc atggaaatca atctaaatgc caacctgtgg 20220 agaaatttcc tgtactccaa catagcgctg tatttgcccg acaagctaaa gtacagtcct 20280 tccaacgtaa aaatttctga taacccaaac acctacgact acatgaacaa gcgagtggtg 20340 gctcccgggt tagtggactg ctacattaac cttggagcac gctggtccct tgactatatg 20400 gacaacgtca acccatttaa ccaccaccgc aatgctggcc tgcgctaccg ctcaatgttg 20460 ctgggcaatg gtcgctatgt gcccttccac atccaggtgc ctcagaagtt ctttgccatt 20520 aaaaacctcc ttctcctgcc gggctcatac acctacgagt ggaacttcag gaaggatgtt 20580 aacatggttc tgcagagctc cctaggaaat gacctaaggg ttgacggagc cagcattaag 20640 tttgatagca tttgccttta cgccaccttc ttccccatgg cccacaacac cgcctccacg 20700 cttgaggcca tgcttagaaa cgacaccaac gaccagtcct ttaacgacta tctctccgcc 20760 gccaacatgc tctaccctat acccgccaac gctaccaacg tgcccatatc catcccctcc 20820 cgcaactggg cggctttccg cggctgggcc ttcacgcgcc ttaagactaa ggaaacccca 20880 tcactgggct cgggctacga cccttattac acctactctg gctctatacc ctacctagat 20940 ggaacctttt acctcaacca cacctttaag aaggtggcca ttacctttga ctcttctgtc 21000 agctggcctg gcaatgaccg cctgcttacc cccaacgagt ttgaaattaa gcgctcagtt 21060 gacggggagg gttacaacgt tgcccagtgt aacatgacca aagactggtt cctggtacaa 21120 atgctagcta actacaacat tggctaccag ggcttctata tcccagagag ctacaaggac 21180 cgcatgtact ccttctttag aaacttccag cccatgagcc gtcaggtggt ggatgatact 21240 aaatacaagg actaccaaca ggtgggcatc ctacaccaac acaacaactc tggatttgtt 21300 ggctaccttg cccccaccat gcgcgaagga caggcctacc ctgctaactt cccctatccg 21360 cttataggca agaccgcagt tgacagcatt acccagaaaa agtttctttg cgatcgcacc 21420 ctttggcgca tcccattctc cagtaacttt atgtccatgg gcgcactcac agacctgggc 21480 caaaaccttc tctacgccaa ctccgcccac gcgctagaca tgacttttga ggtggatccc 21540 atggacgagc ccacccttct ttatgttttg tttgaagtct ttgacgtggt ccgtgtgcac 21600 cggccgcacc gcggcgtcat cgaaaccgtg tacctgcgca cgcccttctc ggccggcaac 21660 gccacaacat aaagaagcaa gcaacatcaa caacagctgc cgccatgggc tccagtgagc 21720 aggaactgaa agccattgtc aaagatcttg gttgtgggcc atattttttg ggcacctatg 21780 acaagcgctt tccaggcttt gtttctccac acaagctcgc ctgcgccata gtcaatacgg 21840 ccggtcgcga gactgggggc gtacactgga tggcctttgc ctggaacccg cactcaaaaa 21900 catgctacct ctttgagccc tttggctttt ctgaccagcg actcaagcag gtttaccagt 21960 ttgagtacga gtcactcctg cgccgtagcg ccattgcttc ttcccccgac cgctgtataa 22020 cgctggaaaa gtccacccaa agcgtacagg ggcccaactc ggccgcctgt ggactattct 22080 gctgcatgtt tctccacgcc tttgccaact ggccccaaac tcccatggat cacaacccca 22140 ccatgaacct tattaccggg gtacccaact ccatgctcaa cagtccccag gtacagccca 22200 ccctgcgtcg caaccaggaa cagctctaca gcttcctgga gcgccactcg ccctacttcc 22260 gcagccacag tgcgcagatt aggagcgcca cttctttttg tcacttgaaa aacatgtaaa 22320 aataatgtac tagagacact ttcaataaag gcaaatgctt ttatttgtac actctcgggt 22380 gattatttac ccccaccctt gccgtctgcg ccgtttaaaa atcaaagggg ttctgccgcg 22440 catcgctatg cgccactggc agggacacgt tgcgatactg gtgtttagtg ctccacttaa 22500 actcaggcac aaccatccgc ggcagctcgg tgaagttttc actccacagg ctgcgcacca 22560 tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa gtcgcagttg gggcctccgc 22620 cctgcgcgcg cgagttgcga tacacagggt tgcagcactg gaacactatc agcgccgggt 22680 ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc cgcgtccagg tcctccgcgt 22740 tgctcagggc gaacggagtc aactttggta gctgccttcc caaaaagggc gcgtgcccag 22800 gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg accgtgcccg gtctgggcgt 22860 taggatacag cgcctgcata aaagccttga tctgcttaaa agccacctga gcctttgcgc 22920 cttcagagaa gaacatgccg caagacttgc cggaaaactg attggccgga caggccgcgt 22980 cgtgcacgca gcaccttgcg tcggtgttgg agatctgcac cacatttcgg ccccaccggt 23040 tcttcacgat cttggccttg ctagactgct ccttcagcgc gcgctgcccg ttttcgctcg 23100 tcacatccat ttcaatcacg tgctccttat ttatcataat gcttccgtgt agacacttaa 23160 gctcgccttc gatctcagcg cagcggtgca gccacaacgc gcagcccgtg ggctcgtgat 23220 gcttgtaggt cacctctgca aacgactgca ggtacgcctg caggaatcgc cccatcatcg 23280 tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc gcggtgctcc tcgttcagcc 23340 aggtcttgca tacggccgcc agagcttcca cttggtcagg cagtagtttg aagttcgcct 23400 ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg cgcagcctcc atgcccttct 23460 cccacgcaga cacgatcggc acactcagcg ggttcatcac cgtaatttca ctttccgctt 23520 cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg cgccactggg tcgtcttcat 23580 tcagccgccg cactgtgcgc ttacctcctt tgccatgctt gattagcacc ggtgggttgc 23640 tgaaacccac catttgtagc gccacatctt ctctttcttc ctcgctgtcc acgattacct 23700 ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt ctttttcttc ttgggcgcaa 23760 tggccaaatc cgccgccgag gtcgatggcc gcgggctggg tgtgcgcggc accagcgcgt 23820 cttgtgatga gtcttcctcg tcctcggact cgatacgccg cctcatccgc ttttttgggg 23880 gcgcccgggg aggcggcggc gacggggacg gggacgacac gtcctccatg gttgggggac 23940 gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg ctgctcctct tcccgactgg 24000 ccatttcctt ctcctatagg cagaaaaaga tcatggagtc agtcgagaag aaggacagcc 24060 taaccgcccc ctctgagttc gccaccaccg cctccaccga tgccgccaac gcgcctacca 24120 ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt gattatcgag caggacccag 24180 gttttgtaag cgaagacgac gaggaccgct cagtaccaac agaggataaa aagcaagacc 24240 aggacaacgc agaggcaaac gaggaacaag tcgggcgggg ggacgaaagg catggcgact 24300 acctagatgt gggagacgac gtgctgttga agcatctgca gcgccagtgc gccattatct 24360 gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat agcggatgtc agccttgcct 24420 acgaacgcca cctattctca ccgcgcgtac cccccaaacg ccaagaaaac ggcacatgcg 24480 agcccaaccc gcgcctcaac ttctaccccg tatttgccgt gccagaggtg cttgccacct 24540 atcacatctt tttccaaaac tgcaagatac ccctatcctg ccgtgccaac cgcagccgag 24600 cggacaagca gctggccttg cggcagggcg ctgtcatacc tgatatcgcc tcgctcaacg 24660 aagtgccaaa aatctttgag ggtcttggac gcgacgagaa gcgcgcggca aacgctctgc 24720 aacaggaaaa cagcgaaaat gaaagtcact ctggagtgtt ggtggaactc gagggtgaca 24780 acgcgcgcct agccgtacta aaacgcagca tcgaggtcac ccactttgcc tacccggcac 24840 ttaacctacc ccccaaggtc atgagcacag tcatgagtga gctgatcgtg cgccgtgcgc 24900 agcccctgga gagggatgca aatttgcaag aacaaacaga ggagggccta cccgcagttg 24960 gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc tgccgacttg gaggagcgac 25020 gcaaactaat gatggccgca gtgctcgtta ccgtggagct tgagtgcatg cagcggttct 25080 ttgctgaccc ggagatgcag cgcaagctag aggaaacatt gcactacacc tttcgacagg 25140 gctacgtacg ccaggcctgc aagatctcca acgtggagct ctgcaacctg gtctcctacc 25200 ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct tcattccacg ctcaagggcg 25260 aggcgcgccg cgactacgtc cgcgactgcg tttacttatt tctatgctac acctggcaga 25320 cggccatggg cgtttggcag cagtgcttgg aggagtgcaa cctcaaggag ctgcagaaac 25380 tgctaaagca aaacttgaag gacctatgga cggccttcaa cgagcgctcc gtggccgcgc 25440 acctggcgga catcattttc cccgaacgcc tgcttaaaac cctgcaacag ggtctgccag 25500 acttcaccag tcaaagcatg ttgcagaact ttaggaactt tatcctagag cgctcaggaa 25560 tcttgcccgc cacctgctgt gcacttccta gcgactttgt gcccattaag taccgcgaat 25620 gccctccgcc gctttggggc cactgctacc ttctgcagct agccaactac cttgcctacc 25680 actctgacat aatggaagac gtgagcggtg acggtctact ggagtgtcac tgtcgctgca 25740 acctatgcac cccgcaccgc tccctggttt gcaattcgca gctgcttaac gaaagtcaaa 25800 ttatcggtac ctttgagctg cagggtccct cgcctgacga aaagtccgcg gctccggggt 25860 tgaaactcac tccggggctg tggacgtcgg cttaccttcg caaatttgta cctgaggact 25920 accacgccca cgagattagg ttctacgaag accaatcccg cccgccaaat gcggagctta 25980 ccgcctgcgt cattacccag ggccacattc ttggccaatt gcaagccatc aacaaagccc 26040 gccaagagtt tctgctacga aagggacggg gggtttactt ggacccccag tccggcgagg 26100 agctcaaccc aatccccccg ccgccgcagc cctatcagca gcagccgcgg gcccttgctt 26160 cccaggatgg cacccaaaaa gaagctgcag ctgccgccgc cacccacgga cgaggaggaa 26220 tactgggaca gtcaggcaga ggaggttttg gacgaggagg aggaggacat gatggaagac 26280 tgggagagcc tagacgagga agcttccgag gtcgaagagg tgtcagacga aacaccgtca 26340 ccctcggtcg cattcccctc gccggcgccc cagaaatcgg caaccggttc cagcatggct 26400 acaacctccg ctcctcaggc gccgccggca ctgcccgttc gccgacccaa ccgtagatgg 26460 gacaccactg gaaccagggc cggtaagtcc aagcagccgc cgccgttagc ccaagagcaa 26520 caacagcgcc aaggctaccg ctcatggcgc gggcacaaga acgccatagt tgcttgcttg 26580 caagactgtg ggggcaacat ctccttcgcc cgccgctttc ttctctacca tcacggcgtg 26640 gccttccccc gtaacatcct gcattactac cgtcatctct acagcccata ctgcaccggc 26700 ggcagcggca gcggcagcaa cagcagcggc cacacagaag caaaggcgac cggatagcaa 26760 gactctgaca aagcccaaga aatccacagc ggcggcagca gcaggaggag gagcgctgcg 26820 tctggcgccc aacgaacccg tatcgacccg cgagcttaga aacaggattt ttcccactct 26880 gtatgctata tttcaacaga gcaggggcca agaacaagag ctgaaaataa aaaacaggtc 26940 tctgcgatcc ctcacccgca gctgcctgta tcacaaaagc gaagatcagc ttcggcgcac 27000 gctggaagac gcggaggctc tcttcagtaa atactgcgcg ctgactctta aggactagtt 27060 tcgcgccctt tctcaaattt aagcgcgaaa actacgtcat ctccagcggc cacacccggc 27120 gccagcacct gtcgtcagcg ccatttatga gcaaggaaat tcccacgccc tacatgtgga 27180 gttaccagcc acaaatggga cttgcggctg gagctgccca agactactca acccgaataa 27240 actacatgag cgcgggaccc cacatgatat cccgggtcaa cggaatacgc gcccaccgaa 27300 accgaattct cctggaacag gcggctatta ccaccacacc tcgtaataac cttaatcccc 27360 gtagttggcc cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc 27420 ccagagacgc ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct 27480 ttcgtcacag ggtgcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag 27540 gtattcagct caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat 27600 ttcagatcgg cggcgccggc cgctcttcat tcacgcctcg tcaggcaatc ctaactctgc 27660 agacctcgtc ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt 27720 ttgtgccatc ggtctacttt aaccccttct cgggacctcc cggccactat ccggatcaat 27780 ttattcctaa ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg 27840 gagaggcaga gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg 27900 cccgcgactc cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg 27960 cgcacggcgt ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta 28020 cccagcgccc cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca 28080 actgtcctaa ccctggatta catcaagatc tttgttgcca tctctgtgct gagtataata 28140 aatacagaaa ttaaaatata ctggggctcc tatcgccatc ctgtaaacgc caccgtcttc 28200 acccgcccaa gcaaaccaag gcgaacctta cctggtactt ttaacatctc tccctctgtg 28260 atttacaaca gtttcaaccc agacggagtg agtctacgag agaacctctc cgagctcagc 28320 tactccatca gaaaaaacac caccctcctt acctgccggg aacgtacgag tgcgtcaccg 28380 gccgctgcac cacacctacc gcctgaccgt aaaccagact ttttccggac agacctcaat 28440 aactctgttt accagaacag gaggtgagct tagaaaaccc ttagggtatt aggccaaagg 28500 cgcagctact gtggggttta tgaacaattc aagcaactct acgggctatt ctaattcagg 28560 tttctctaga atcggggttg gggttattct ctgtcttgtg attctcttta ttcttatact 28620 aacgcttctc tgcctaaggc tcgccgcctg ctgtgtgcac atttgcattt attgtcagct 28680 ttttaaacgc tggggtcgcc acccaagatg attaggtaca taatcctagg tttactcacc 28740 cttgcgtcag cccacggtac cacccaaaag gtggatttta aggagccagc ctgtaatgtt 28800 acattcgcag ctgaagctaa tgagtgcacc actcttataa aatgcaccac agaacatgaa 28860 aagctgctta ttcgccacaa aaacaaaatt ggcaagtatg ctgtttatgc tatttggcag 28920 ccaggtgaca ctacagagta taatgttaca gttttccagg gtaaaagtca taaaactttt 28980 atgtatactt ttccatttta tgaaatgtgc gacattacca tgtacatgag caaacagtat 29040 aagttgtggc ccccacaaaa ttgtgtggaa aacactggca ctttctgctg cactgctatg 29100 ctaattacag tgctcgcttt ggtctgtacc ctactctata ttaaatacaa aagcagacgc 29160 agctttattg aggaaaagaa aatgccttaa tttactaagt tacaaagcta atgtcaccac 29220 taactgcttt actcgctgct tgcaaaacaa attcaaaaag ttagcattat aattagaata 29280 ggatttaaac cccccggtca tttcctgctc aataccattc ccctgaacaa ttgactctat 29340 gtgggatatg ctccagcgct acaaccttga agtcaggctt cctggatgtc agcatctgac 29400 tttggccagc acctgtcccg cggatttgtt ccagtccaac tacagcgacc caccctaaca 29460 gagatgacca acacaaccaa cgcggccgcc gctaccggac ttacatctac cacaaataca 29520 ccccaagttt ctgcctttgt caataactgg gataacttgg gcatgtggtg gttctccata 29580 gcgcttatgt ttgtatgcct tattattatg tggctcatct gctgcctaaa gcgcaaacgc 29640 gcccgaccac ccatctatag tcccatcatt gtgctacacc caaacaatga tggaatccat 29700 agattggacg gactgaaaca catgttcttt tctcttacag tatgattaaa tgagacatga 29760 ttcctcgagt ttttatatta ctgacccttg ttgcgctttt ttgtgcgtgc tccacattgg 29820 ctgcggtttc tcacatcgaa gtagactgca ttccagcctt cacagtctat ttgctttacg 29880 gatttgtcac cctcacgctc atctgcagcc tcatcactgt ggtcatcgcc tttatccagt 29940 gcattgactg ggtctgtgtg cgctttgcat atctcagaca ccatccccag tacagggaca 30000 ggactatagc tgagcttctt agaattcttt aattatgaaa tttactgtga cttttctgct 30060 gattatttgc accctatctg cgttttgttc cccgacctcc aagcctcaaa gacatatatc 30120 atgcagattc actcgtatat ggaatattcc aagttgctac aatgaaaaaa gcgatctttc 30180 cgaagcctgg ttatatgcaa tcatctctgt tatggtgttc tgcagtacca tcttagccct 30240 agctatatat ccctaccttg acattggctg gaacgcaata gatgccatga accacccaac 30300 tttccccgcg cccgctatgc ttccactgca acaagttgtt gccggcggct ttgtcccagc 30360 caatcagcct cgcccacctt ctcccacccc cactgaaatc agctacttta atctaacagg 30420 aggagatgac tgacacccta gatctagaaa tggacggaat tattacagag cagcgcctgc 30480 tagaaagacg cagggcagcg gccgagcaac agcgcatgaa tcaagagctc caagacatgg 30540 ttaacttgca ccagtgcaaa aggggtatct tttgtctggt aaagcaggcc aaagtcacct 30600 acgacagtaa taccaccgga caccgcctta gctacaagtt gccaaccaag cgtcagaaat 30660 tggtggtcat ggtgggagaa aagcccatta ccataactca gcactcggta gaaaccgaag 30720 gctgcattca ctcaccttgt caaggacctg aggatctctg cacccttatt aagaccctgt 30780 gcggtctcaa agatcttatt ccctttaact aataaaaaaa aataataaag catcacttac 30840 ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc 30900 cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg 30960 tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag 31020 cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt 31080 cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt 31140 ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt 31200 gcgctcaaaa tgggcaacgg cctctctctg gacgaggccg gcaaccttac ctcccaaaat 31260 gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct 31320 gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc 31380 gcgggcaaca cactcaccat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt 31440 agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca 31500 ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact 31560 actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa 31620 ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac tttgaccgta 31680 gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc 31740 ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat 31800 tctcaaaaca gacgccttat acttgatgtt agttatccgt ttgatgctca aaaccaacta 31860 aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac 31920 tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac 31980 ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat 32040 gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc 32100 catggcctag aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt 32160 tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg 32220 accacaccag ctccatctcc taactgtaga ctaaatgcag agaaagatgc taaactcact 32280 ttggtcttaa caaaatgtgg cagtcaaata cttgctacag tttcagtttt ggctgttaaa 32340 ggcagtttgg ctccaatatc tggaacagtt caaagtgctc atcttattat aagatttgac 32400 gaaaatggag tgctactaaa caattccttc ctggacccag aatattggaa ctttagaaat 32460 ggagatctta ctgaaggcac agcctataca aacgctgttg gatttatgcc taacctatca 32520 gcttatccaa aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca agtttactta 32580 aacggagaca aaactaaacc tgtaacacta accattacac taaacggtac acaggaaaca 32640 ggagacacaa ctccaagtgc atactctatg tcattttcat gggactggtc tggccacaac 32700 tacattaatg aaatatttgc cacatcctct tacacttttt catacattgc ccaagaataa 32760 agaatcgttt gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcgaatca 32820 tttttcattc agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa 32880 tcaaacctac atgggggtag agtcataatc gtgcatcagg atagggcggt ggtgctgcag 32940 cagcgcgcga ataaactgct gccgccgccg ctccgtcctg caggaataca acatggcagt 33000 ggtctcctca gcgatgattc gcaccgcccg cagcataagg cgccttgtcc tccgggcaca 33060 gcagcgcacc ctgatctcac ttaaatcagc acagtaactg cagcacagca ccacaatatt 33120 gttcaaaatc ccacagtgca aggcgctgta tccaaagctc atggcgggga ccacagaacc 33180 cacgtggcca tcataccaca agcgcaggta gattaagtgg cgacccctca taaacacgct 33240 ggacataaac attacctctt ttggcatgtt gtaattcacc acctcccggt accatataaa 33300 cctctgatta aacatggcgc catccaccac catcctaaac cagctggcca aaacctgccc 33360 gccggctata cactgcaggg aaccgggact ggaacaatga cagtggagag cccaggactc 33420 gtaaccatgg atcatcatgc tcgtcatgat atcaatgttg gcacaacaca ggcacacgtg 33480 catacacttc ctcaggatta caagctcctc ccgcgttaga accatatccc agggaacaac 33540 ccattcctga atcagcgtaa atcccacact gcagggaaga cctcgcacgt aactcacgtt 33600 gtgcattgtc aaagtgttac attcgggcag cagcggatga tcctccagta tggtagcgcg 33660 ggtttctgtc tcaaaaggag gtagacgatc cctactgtac ggagtgcgcc gagacaaccg 33720 agatcgtgtt ggtcgtagtg tcatgccaaa tggaacgccg gacgtagtca tatttcctga 33780 agcaaaacca ggtgcgggcg tgacaaacag atctgcgtct ccggtctcgc cgcttagatc 33840 gctctgtgta gtagttgtag tatatccact ctctcaaagc atccaggcgc cccctggctt 33900 cgggttctat gtaaactcct tcatgcgccg ctgccctgat aacatccacc accgcagaat 33960 aagccacacc cagccaacct acacattcgt tctgcgagtc acacacggga ggagcgggaa 34020 gagctggaag aaccatgttt ttttttttat tccaaaagat tatccaaaac ctcaaaatga 34080 agatctatta agtgaacgcg ctcccctccg gtggcgtggt caaactctac agccaaagaa 34140 cagataatgg catttgtaag atgttgcaca atggcttcca aaaggcaaac ggccctcacg 34200 tccaagtgga cgtaaaggct aaacccttca gggtgaatct cctctataaa cattccagca 34260 ccttcaacca tgcccaaata attctcatct cgccaccttc tcaatatatc tctaagcaaa 34320 tcccgaatat taagtccggc cattgtaaaa atctgctcca gagcgccctc caccttcagc 34380 ctcaagcagc gaatcatgat tgcaaaaatt caggttcctc acagacctgt ataagattca 34440 aaagcggaac attaacaaaa ataccgcgat cccgtaggtc ccttcgcagg gccagctgaa 34500 cataatcgtg caggtctgca cggaccagcg cggccacttc cccgccagga accatgacaa 34560 aagaacccac actgattatg acacgcatac tcggagctat gctaaccagc gtagccccga 34620 tgtaagcttg ttgcatgggc ggcgatataa aatgcaaggt gctgctcaaa aaatcaggca 34680 aagcctcgcg caaaaaagaa agcacatcgt agtcatgctc atgcagataa aggcaggtaa 34740 gctccggaac caccacagaa aaagacacca tttttctctc aaacatgtct gcgggtttct 34800 gcataaacac aaaataaaat aacaaaaaaa catttaagcc tgtcttacaa caggaaaaac 34860 aacccttata agcataagac ggactacggc catgccggcg tgaccgtaaa aaaactggtc 34920 accgtgatta aaaagcacca ccgacagctc ctcggtcatg tccggagtca taatgtaaga 34980 ctcggtaaac acatcaggtt gattcacatc ggtcagtgct aaaaagcgac cgaaatagcc 35040 cgggggaata catacccgca ggcgtagaga caacattaca gcccccatag gaggtataac 35100 aaaattaata ggagagaaaa acacataaac acctgaaaaa ccctcctgcc taggcaaaat 35160 agcaccctcc cgctccagaa caacatacag cgcttccaca gcggcagcca taacagtcag 35220 ccttaccagt aaaaaagaaa acctattaaa aaaacaccac tcgacacggc accagctcaa 35280 tcagtcacag tgtaaaaaag ggccaagtgc agagcgagta tatataggac taaaaaatga 35340 cgtaacggtt aaagtccaca aaaaacaccc agaaaaccgc acgcgaacct acgcccagaa 35400 acgaaagcca aaaaacccac aacttcctca aatcgtcact tccgttttcc cacgttacgt 35460 cacttcccat tttaagaaaa ctacaattcc caacacatac aagttactcc gccctaaaac 35520 ctacgtcacc cgccccgttc ccacgccccg cgccacgtca caaactccac cccctcatta 35580 tcatattggc ttcaatccaa aataaggtat attattgatg atg 35623 <210> 16 <211> 35198 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO292) <400> 16 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgaccgaaga aatggccgcc agtcttttgg accagctgat 600 cgaagaggta ctggctgata atcttccacc tcctagccat tttgaaccac ctacccttca 660 cgaactgtat gatttagacg tgacggcccc cgaagatccc aacgaggagg cggtttcgca 720 gatttttccc gactctgtaa tgttggcggt gcaggaaggg attgacttac tcacttttcc 780 gccggcgccc ggttctccgg agccgcctca cctttcccgg cagcccgagc agccggagca 840 gagagccttg ggtccggttt ctatgccaaa ccttgtaccg gaggtgatcg atcttacctg 900 ccacgaggct ggctttccac ccagtgacga cgaggatgaa gagggtgagg agtttgtgtt 960 agattatgtg gagcaccccg ggcacggttg caggtcttgt cattatcacc ggaggaatac 1020 gggggaccca gatattatgt gttcgctttg ctatatgagg acctgtggca tgtttgtcta 1080 cagtaagtga aaattatggg cagtgggtga tagagtggtg ggtttggtgt ggtaattttt 1140 tttttaattt ttacagtttt gtggtttaaa gaattttgta ttgtgatttt tttaaaaggt 1200 cctgtgtctg aacctgagcc tgagcccgag ccagaaccgg agcctgcaag acctacccgc 1260 cgtcctaaaa tggcgcctgc tatcctgaga cgcccgacat cacctgtgtc tagagaatgc 1320 aatagtagta cggatagctg tgactccggt ccttctaaca cacctcctga gatacacccg 1380 gtggtcccgc tgtgccccat taaaccagtt gccgtgagag ttggtgggcg tcgccaggct 1440 gtggaatgta tcgaggactt gcttaacgag cctgggcaac ctttggactt gagctgtaaa 1500 cgccccaggc cataaggtgt aaacctgtga ttgcgtgtgt ggttaacgcc tttgtttgct 1560 gaatgagttg atgtaagttt aataaagggt gagataatgt ttaacttgca tggcgtgtta 1620 aatggggcgg ggcttaaagg gtatataatg cgccgtgggc taatcttggt tacatctgac 1680 ctcatggagg cttgggagtg tttggaagat ttttctgctg tgcgtaactt gctggaacag 1740 agctctaaca gtacctcttg gttttggagg tttctgtggg gctcatccca ggcaaagtta 1800 gtctgcagaa ttaaggagga ttacaagtgg gaatttgaag agcttttgaa atcctgtggt 1860 gagctgtttg attctttgaa tctgggtcac caggcgcttt tccaagagaa ggtcatcaag 1920 actttggatt tttccacacc ggggcgcgct gcggctgctg ttgctttttt gagttttata 1980 aaggataaat ggagcgaaga aacccatctg agcggggggt acctgctgga ttttctggcc 2040 atgcatctgt ggagagcggt tgtgagacac aagaatcgcc tgctactgtt gtcttccgtc 2100 cgcccggcga taataccgac ggaggagcag cagcagcagc aggaggaagc caggcggcgg 2160 cggcaggagc agagcccatg gaacccgaga gccggcctgg accctcggga atgaatgttg 2220 tacaggtggc tgaactgtat ccagaactga gacgcatttt gacaattaca gaggatgggc 2280 aggggctaaa gggggtaaag agggagcggg gggcttgtga ggctacagag gaggctagga 2340 atctagcttt tagcttaatg accagacacc gtcctgagtg tattactttt caacagatca 2400 aggataattg cgctaatgag cttgatctgc tggcgcagaa gtattccata gagcagctga 2460 ccacttactg gctgcagcca ggggatgatt ttgaggaggc tattagggta tatgcaaagg 2520 tggcacttag gccagattgc aagtacaaga tcagcaaact tgtaaatatc aggaattgtt 2580 gctacatttc tgggaacggg gccgaggtgg agatagatac ggaggatagg gtggccttta 2640 gatgtagcat gataaatatg tggccggggg tgcttggcat ggacggggtg gttattatga 2700 atgtaaggtt tactggcccc aattttagcg gtacggtttt cctggccaat accaacctta 2760 tcctacacgg tgtaagcttc tatgggttta acaatacctg tgtggaagcc tggaccgatg 2820 taagggttcg gggctgtgcc ttttactgct gctggaaggg ggtggtgtgt cgccccaaaa 2880 gcagggcttc aattaagaaa tgcctctttg aaaggtgtac cttgggtatc ctgtctgagg 2940 gtaactccag ggtgcgccac aatgtggcct ccgactgtgg ttgcttcatg ctagtgaaaa 3000 gcgtggctgt gattaagcat aacatggtat gtggcaactg cgaggacagg gcctctcaga 3060 tgctgacctg ctcggacggc aactgtcacc tgctgaagac cattcacgta gccagccact 3120 ctcgcaaggc ctggccagtg tttgagcata acatactgac ccgctgttcc ttgcatttgg 3180 gtaacaggag gggggtgttc ctaccttacc aatgcaattt gagtcacact aagatattgc 3240 ttgagcccga gagcatgtcc aaggtgaacc tgaacggggt gtttgacatg accatgaaga 3300 tctggaaggt gctgaggtac gatgagaccc gcaccaggtg cagaccctgc gagtgtggcg 3360 gtaaacatat taggaaccag cctgtgatgc tggatgtgac cgaggagctg aggcccgatc 3420 acttggtgct ggcctgcacc cgcgctgagt ttggctctag cgatgaagat acagattgag 3480 gtactgaaat gtgtgggcgt ggcttaaggg tgggaaagaa tatataaggt gggggtctta 3540 tgtagttttg tatctgtttt gcagcagccg ccgccgccat gagcaccaac tcgtttgatg 3600 gaagcattgt gagctcatat ttgacaacgc gcatgccccc atgggccggg gtgcgtcaga 3660 atgtgatggg ctccagcatt gatggtcgcc ccgtcctgcc cgcaaactct actaccttga 3720 cctacgagac cgtgtctgga acgccgttgg agactgcagc ctccgccgcc gcttcagccg 3780 ctgcagccac cgcccgcggg attgtgactg actttgcttt cctgagcccg cttgcaagca 3840 gtgcagcttc ccgttcatcc gcccgcgatg acaagttgac ggctcttttg gcacaattgg 3900 attctttgac ccgggaactt aatgtcgttt ctcagcagct gttggatctg cgccagcagg 3960 tttctgccct gaaggcttcc tcccctccca atgcggttta aaacataaat aaaaaaccag 4020 actctgtttg gatttggatc aagcataagt gtcttgctgt ctttatttag gggttttgcg 4080 cgcgcggtag gcccgggacc agcggtctcg gtcgttgagg gtcctgtgta ttttttccag 4140 gacgtggtaa aggtgactct ggatgttcag atacatgggc ataagcccgt ctctggggtg 4200 gaggtagcac cactgcagag cttcatgctg cggggtggtg ttgtagatga tccagtcgta 4260 gcaggagcgc tgggcgtggt gcctaaaaat gtctttcagt agcaagctga ttgccagggg 4320 caggcccttg gtgtaagtgt ttacaaagcg gttaagctgg gatgggtgca tacgtgggga 4380 tatgagatgc atcttggact gtatttttag gttggctatg ttcccagcca tatccctccg 4440 gggattcatg ttgtgcagaa ccaccagcac agtgtatccg gtgcacttgg gaaatttgtc 4500 atgtagctta gaaggaaatg cgtggaagaa cttggagacg cccttgtgac ctccaagatt 4560 ttccatgcat tcgtccataa tgatggcaat gggcccacgg gcggcggcct gggcgaagat 4620 atttctggga tcactaacgt catagttgtg ttccaggatg agatcgtcat aggccatttt 4680 tacaaagcgc gggcggaggg tgccagactg cggtataatg gttccatccg gcccaggggc 4740 gtagttaccc tcacagattt gcatttccca cgctttgagt tcagatgggg ggatcatgtc 4800 tacctgcggg gcgatgaaga aaacggtttc cggggtaggg gagatcagct gggaagaaag 4860 caggttcctg agcagctgcg acttaccgca gccggtgggc ccgtaaatca cacctattac 4920 cgggtgcaac tggtagttaa gagagctgca gctgccgtca tccctgagca ggggggccac 4980 ttcgttaagc atgtccctga ctcgcatgtt ttccctgacc aaatccgcca gaaggcgctc 5040 gccgcccagc gatagcagtt cttgcaagga agcaaagttt ttcaacggtt tgagaccgtc 5100 cgccgtaggc atgcttttga gcgtttgacc aagcagttcc aggcggtccc acagctcggt 5160 cacctgctct acggcatctc gatccagcat atctcctcgt ttcgcgggtt ggggcggctt 5220 tcgctgtacg gcagtagtcg gtgctcgtcc agacgggcca gggtcatgtc tttccacggg 5280 cgcagggtcc tcgtcagcgt agtctgggtc acggtgaagg ggtgcgctcc gggctgcgcg 5340 ctggccaggg tgcgcttgag gctggtcctg ctggtgctga agcgctgccg gtcttcgccc 5400 tgcgcgtcgg ccaggtagca tttgaccatg gtgtcatagt ccagcccctc cgcggcgtgg 5460 cccttggcgc gcagcttgcc cttggaggag gcgccgcacg aggggcagtg cagacttttg 5520 agggcgtaga gcttgggcgc gagaaatacc gattccgggg agtaggcatc cgcgccgcag 5580 gccccgcaga cggtctcgca ttccacgagc caggtgagct ctggccgttc ggggtcaaaa 5640 accaggtttc ccccatgctt tttgatgcgt ttcttacctc tggtttccat gagccggtgt 5700 ccacgctcgg tgacgaaaag gctgtccgtg tccccgtata cagacttgag aggcctgtcc 5760 tcgagcggtg ttccgcggtc ctcctcgtat agaaactcgg accactctga gacaaaggct 5820 cgcgtccagg ccagcacgaa ggaggctaag tgggaggggt agcggtcgtt gtccactagg 5880 gggtccactc gctccagggt gtgaagacac atgtcgccct cttcggcatc aaggaaggtg 5940 attggtttgt aggtgtaggc cacgtgaccg ggtgttcctg aaggggggct ataaaagggg 6000 gtgggggcgc gttcgtcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg 6060 ggtgagtact ccctctgaaa agcgggcatg acttctgcgc taagattgtc agtttccaaa 6120 aacgaggagg atttgatatt cacctggccc gcggtgatgc ctttgagggt ggccgcatcc 6180 atctggtcag aaaagacaat ctttttgttg tcaagcttgg tggcaaacga cccgtagagg 6240 gcgttggaca gcaacttggc gatggagcgc agggtttggt ttttgtcgcg atcggcgcgc 6300 tccttggccg cgatgtttag ctgcacgtat tcgcgcgcaa cgcaccgcca ttcgggaaag 6360 acggtggtgc gctcgtcggg caccaggtgc acgcgccaac cgcggttgtg cagggtgaca 6420 aggtcaacgc tggtggctac ctctccgcgt aggcgctcgt tggtccagca gaggcggccg 6480 cccttgcgcg agcagaatgg cggtaggggg tctagctgcg tctcgtccgg ggggtctgcg 6540 tccacggtaa agaccccggg cagcaggcgc gcgtcgaagt agtctatctt gcatccttgc 6600 aagtctagcg cctgctgcca tgcgcgggcg gcaagcgcgc gctcgtatgg gttgagtggg 6660 ggaccccatg gcatggggtg ggtgagcgcg gaggcgtaca tgccgcaaat gtcgtaaacg 6720 tagaggggct ctctgagtat tccaagatat gtagggtagc atcttccacc gcggatgctg 6780 gcgcgcacgt aatcgtatag ttcgtgcgag ggagcgagga ggtcgggacc gaggttgcta 6840 cgggcgggct gctctgctcg gaagactatc tgcctgaaga tggcatgtga gttggatgat 6900 atggttggac gctggaagac gttgaagctg gcgtctgtga gacctaccgc gtcacgcacg 6960 aaggaggcgt aggagtcgcg cagcttgttg accagctcgg cggtgacctg cacgtctagg 7020 gcgcagtagt ccagggtttc cttgatgatg tcatacttat cctgtccctt ttttttccac 7080 agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt actcttggat cggaaacccg 7140 tcggcctccg aacggtaaga gcctagcatg tagaactggt tgacggcctg gtaggcgcag 7200 catccctttt ctacgggtag cgcgtatgcc tgcgcggcct tccggagcga ggtgtgggtg 7260 agcgcaaagg tgtccctgac catgactttg aggtactggt atttgaagtc agtgtcgtcg 7320 catccgccct gctcccagag caaaaagtcc gtgcgctttt tggaacgcgg atttggcagg 7380 gcgaaggtga catcgttgaa gagtatcttt cccgcgcgag gcataaagtt gcgtgtgatg 7440 cggaagggtc ccggcacctc ggaacggttg ttaattacct gggcggcgag cacgatctcg 7500 tcaaagccgt tgatgttgtg gcccacaatg taaagttcca agaagcgcgg gatgcccttg 7560 atggaaggca attttttaag ttcctcgtag gtgagctctt caggggagct gagcccgtgc 7620 tctgaaaggg cccagtctgc aagatgaggg ttggaagcga cgaatgagct ccacaggtca 7680 cgggccatta gcatttgcag gtggtcgcga aaggtcctaa actggcgacc tatggccatt 7740 ttttctgggg tgatgcagta gaaggtaagc gggtcttgtt cccagcggtc ccatccaagg 7800 ttcgcggcta ggtctcgcgc ggcagtcact agaggctcat ctccgccgaa cttcatgacc 7860 agcatgaagg gcacgagctg cttcccaaag gcccccatcc aagtataggt ctctacatcg 7920 taggtgacaa agagacgctc ggtgcgagga tgcgagccga tcgggaagaa ctggatctcc 7980 cgccaccaat tggaggagtg gctattgatg tggtgaaagt agaagtccct gcgacgggcc 8040 gaacactcgt gctggctttt gtaaaaacgt gcgcagtact ggcagcggtg cacgggctgt 8100 acatcctgca cgaggttgac ctgacgaccg cgcacaagga agcagagtgg gaatttgagc 8160 ccctcgcctg gcgggtttgg ctggtggtct tctacttcgg ctgcttgtcc ttgaccgtct 8220 ggctgctcga ggggagttac ggtggatcgg accaccacgc cgcgcgagcc caaagtccag 8280 atgtccgcgc gcggcggtcg gagcttgatg acaacatcgc gcagatggga gctgtccatg 8340 gtctggagct cccgcggcgt caggtcaggc gggagctcct gcaggtttac ctcgcataga 8400 cgggtcaggg cgcgggctag atccaggtga tacctaattt ccaggggctg gttggtggcg 8460 gcgtcgatgg cttgcaagag gccgcatccc cgcggcgcga ctacggtacc gcgcggcggg 8520 cggtgggccg cgggggtgtc cttggatgat gcatctaaaa gcggtgacgc gggcgagccc 8580 ccggaggtag ggggggctcc ggacccgccg ggagaggggg caggggcacg tcggcgccgc 8640 gcgcgggcag gagctggtgc tgcgcgcgta ggttgctggc gaacgcgacg acgcggcggt 8700 tgatctcctg aatctggcgc ctctgcgtga agacgacggg cccggtgagc ttgagcctga 8760 aagagagttc gacagaatca atttcggtgt cgttgacggc ggcctggcgc aaaatctcct 8820 gcacgtctcc tgagttgtct tgataggcga tctcggccat gaactgctcg atctcttcct 8880 cctggagatc tccgcgtccg gctcgctcca cggtggcggc gaggtcgttg gaaatgcggg 8940 ccatgagctg cgagaaggcg ttgaggcctc cctcgttcca gacgcggctg tagaccacgc 9000 ccccttcggc atcgcgggcg cgcatgacca cctgcgcgag attgagctcc acgtgccggg 9060 cgaagacggc gtagtttcgc aggcgctgaa agaggtagtt gagggtggtg gcggtgtgtt 9120 ctgccacgaa gaagtacata acccagcgtc gcaacgtgga ttcgttgata tcccccaagg 9180 cctcaaggcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc 9240 gcgccgacac ggttaactcc tcctccagaa gacggatgag ctcggcgaca gtgtcgcgca 9300 cctcgcgctc aaaggctaca ggggcctctt cttcttcttc aatctcctct tccataaggg 9360 cctccccttc ttcttcttct ggcggcggtg ggggaggggg gacacggcgg cgacgacggc 9420 gcaccgggag gcggtcgaca aagcgctcga tcatctcccc gcggcgacgg cgcatggtct 9480 cggtgacggc gcggccgttc tcgcgggggc gcagttggaa gacgccgccc gtcatgtccc 9540 ggttatgggt tggcgggggg ctgccatgcg gcagggatac ggcgctaacg atgcatctca 9600 acaattgttg tgtaggtact ccgccgccga gggacctgag cgagtccgca tcgaccggat 9660 cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc gcaaggtagg ctgagcaccg 9720 tggcgggcgg cagcgggcgg cggtcggggt tgtttctggc ggaggtgctg ctgatgatgt 9780 aattaaagta ggcggtcttg agacggcgga tggtcgacag aagcaccatg tccttgggtc 9840 cggcctgctg aatgcgcagg cggtcggcca tgccccaggc ttcgttttga catcggcgca 9900 ggtctttgta gtagtcttgc atgagccttt ctaccggcac ttcttcttct ccttcctctt 9960 gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga gtttggccgt aggtggcgcc 10020 ctcttcctcc catgcgtgtg accccgaagc ccctcatcgg ctgaagcagg gctaggtcgg 10080 cgacaacgcg ctcggctaat atggcctgct gcacctgcgt gagggtagac tggaagtcat 10140 ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt gtaagtgcag ttggccataa 10200 cggaccagtt aacggtctgg tgacccggct gcgagagctc ggtgtacctg agacgcgagt 10260 aagccctcga gtcaaatacg tagtcgttgc aagtccgcac caggtactgg tatcccacca 10320 aaaagtgcgg cggcggctgg cggtagaggg gccagcgtag ggtggccggg gctccggggg 10380 cgagatcttc caacataagg cgatgatatc cgtagatgta cctggacatc caggtgatgc 10440 cggcggcggt ggtggaggcg cgcggaaagt cgcggacgcg gttccagatg ttgcgcagcg 10500 gcaaaaagtg ctccatggtc gggacgctct ggccggtcag gcgcgcgcaa tcgttgacgc 10560 tctagaccgt gcaaaaggag agcctgtaag cgggcactct tccgtggtct ggtggataaa 10620 ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc cgtatccggc cgtccgccgt 10680 gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga caacggggga 10740 gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc gctagctttt ttggccactg 10800 gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc tcgctccctg 10860 tagccggagg gttattttcc aagggttgag tcgcgggacc cccggttcga gtctcggacc 10920 ggccggactg cggcgaacgg gggtttgcct ccccgtcatg caagaccccg cttgcaaatt 10980 cctccggaaa cagggacgag cccctttttt gcttttccca gatgcatccg gtgctgcggc 11040 agatgcgccc ccctcctcag cagcggcaag agcaagagca gcggcagaca tgcagggcac 11100 cctcccctcc tcctaccgcg tcaggagggg cgacatccgc ggttgacgcg gcagcagatg 11160 gtgattacga acccccgcgg cgccgggccc ggcactacct ggacttggag gagggcgagg 11220 gcctggcgcg gctaggagcg ccctctcctg agcggtaccc aagggtgcag ctgaagcgtg 11280 atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg cgaccgcgag ggagaggagc 11340 ccgaggagat gcgggatcga aagttccacg cagggcgcga gctgcggcat ggcctgaatc 11400 gcgagcggtt gctgcgcgag gaggactttg agcccgacgc gcgaaccggg attagtcccg 11460 cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata cgagcagacg gtgaaccagg 11520 agattaactt tcaaaaaagc tttaacaacc acgtgcgtac gcttgtggcg cgcgaggagg 11580 tggctatagg actgatgcat ctgtgggact ttgtaagcgc gctggagcaa aacccaaata 11640 gcaagccgct catggcgcag ctgttcctta tagtgcagca cagcagggac aacgaggcat 11700 tcagggatgc gctgctaaac atagtagagc ccgagggccg ctggctgctc gatttgataa 11760 acatcctgca gagcatagtg gtgcaggagc gcagcttgag cctggctgac aaggtggccg 11820 ccatcaacta ttccatgctt agcctgggca agttttacgc ccgcaagata taccataccc 11880 cttacgttcc catagacaag gaggtaaaga tcgaggggtt ctacatgcgc atggcgctga 11940 aggtgcttac cttgagcgac gacctgggcg tttatcgcaa cgagcgcatc cacaaggccg 12000 tgagcgtgag ccggcggcgc gagctcagcg accgcgagct gatgcacagc ctgcaaaggg 12060 ccctggctgg cacgggcagc ggcgatagag aggccgagtc ctactttgac gcgggcgctg 12120 acctgcgctg ggccccaagc cgacgcgccc tggaggcagc tggggccgga cctgggctgg 12180 cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga ggaatatgac gaggacgatg 12240 agtacgagcc agaggacggc gagtactaag cggtgatgtt tctgatcaga tgatgcaaga 12300 cgcaacggac ccggcggtgc gggcggcgct gcagagccag ccgtccggcc ttaactccac 12360 ggacgactgg cgccaggtca tggaccgcat catgtcgctg actgcgcgca atcctgacgc 12420 gttccggcag cagccgcagg ccaaccggct ctccgcaatt ctggaagcgg tggtcccggc 12480 gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta aacgcgctgg ccgaaaacag 12540 ggccatccgg cccgacgagg ccggcctggt ctacgacgcg ctgcttcagc gcgtggctcg 12600 ttacaacagc ggcaacgtgc agaccaacct ggaccggctg gtgggggatg tgcgcgaggc 12660 cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg ggctccatgg ttgcactaaa 12720 cgccttcctg agtacacagc ccgccaacgt gccgcgggga caggaggact acaccaactt 12780 tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa agtgaggtgt accagtctgg 12840 gccagactat tttttccaga ccagtagaca aggcctgcag accgtaaacc tgagccaggc 12900 tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc acaggcgacc gcgcgaccgt 12960 gtctagcttg ctgacgccca actcgcgcct gttgctgctg ctaatagcgc ccttcacgga 13020 cagtggcagc gtgtcccggg acacatacct aggtcacttg ctgacactgt accgcgaggc 13080 cataggtcag gcgcatgtgg acgagcatac tttccaggag attacaagtg tcagccgcgc 13140 gctggggcag gaggacacgg gcagcctgga ggcaacccta aactacctgc tgaccaaccg 13200 gcggcagaag atcccctcgt tgcacagttt aaacagcgag gaggagcgca ttttgcgcta 13260 cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg gtaacgccca gcgtggcgct 13320 ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc tcaaaccggc cgtttatcaa 13380 ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac cccgagtatt tcaccaatgc 13440 catcttgaac ccgcactggc taccgccccc tggtttctac accgggggat tcgaggtgcc 13500 cgagggtaac gatggattcc tctgggacga catagacgac agcgtgtttt ccccgcaacc 13560 gcagaccctg ctagagttgc aacagcgcga gcaggcagag gcggcgctgc gaaaggaaag 13620 cttccgcagg ccaagcagct tgtccgatct aggcgctgcg gccccgcggt cagatgctag 13680 tagcccattt ccaagcttga tagggtctct taccagcact cgcaccaccc gcccgcgcct 13740 gctgggcgag gaggagtacc taaacaactc gctgctgcag ccgcagcgcg aaaaaaacct 13800 gcctccggca tttcccaaca acgggataga gagcctagtg gacaagatga gtagatggaa 13860 gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc ccgcccaccc gtcgtcaaag 13920 gcacgaccgt cagcggggtc tggtgtggga ggacgatgac tcggcagacg acagcagcgt 13980 cctggatttg ggagggagtg gcaacccgtt tgcgcacctt cgccccaggc tggggagaat 14040 gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc accaaggcca tggcaccgag 14100 cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg cgatgtatga ggaaggtcct 14160 cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg cggcggcgct gggttctccc 14220 ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt acctgcggcc taccgggggg 14280 agaaacagca tccgttactc tgagttggca cccctattcg acaccacccg tgtgtacctg 14340 gtggacaaca agtcaacgga tgtggcatcc ctgaactacc agaacgacca cagcaacttt 14400 ctgaccacgg tcattcaaaa caatgactac agcccggggg aggcaagcac acagaccatc 14460 aatcttgacg accggtcgca ctggggcggc gacctgaaaa ccatcctgca taccaacatg 14520 ccaaatgtga acgagttcat gtttaccaat aagtttaagg cgcgggtgat ggtgtcgcgc 14580 ttgcctacta aggacaatca ggtggagctg aaatacgagt gggtggagtt cacgctgccc 14640 gagggcaact actccgagac catgaccata gaccttatga acaacgcgat cgtggagcac 14700 tacttgaaag tgggcagaca gaacggggtt ctggaaagcg acatcggggt aaagtttgac 14760 acccgcaact tcagactggg gtttgacccc gtcactggtc ttgtcatgcc tggggtatat 14820 acaaacgaag ccttccatcc agacatcatt ttgctgccag gatgcggggt ggacttcacc 14880 cacagccgcc tgagcaactt gttgggcatc cgcaagcggc aacccttcca ggagggcttt 14940 aggatcacct acgatgatct ggagggtggt aacattcccg cactgttgga tgtggacgcc 15000 taccaggcga gcttgaaaga tgacaccgaa cagggcgggg gtggcgcagg cggcagcaac 15060 agcagtggca gcggcgcgga agagaactcc aacgcggcag ccgcggcaat gcagccggtg 15120 gaggacatga acgatcatgc cattcgcggc gacacctttg ccacacgggc tgaggagaag 15180 cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg ctgcgcaacc cgaggtcgag 15240 aagcctcaga agaaaccggt gatcaaaccc ctgacagagg acagcaagaa acgcagttac 15300 aacctaataa gcaatgacag caccttcacc cagtaccgca gctggtacct tgcatacaac 15360 tacggcgacc ctcagaccgg aatccgctca tggaccctgc tttgcactcc tgacgtaacc 15420 tgcggctcgg agcaggtcta ctggtcgttg ccagacatga tgcaagaccc cgtgaccttc 15480 cgctccacgc gccagatcag caactttccg gtggtgggcg ccgagctgtt gcccgtgcac 15540 tccaagagct tctacaacga ccaggccgtc tactcccaac tcatccgcca gtttacctct 15600 ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc gccagccccc 15660 accatcacca ccgtcagtga aaacgttcct gctctcacag atcacgggac gctaccgctg 15720 cgcaacagca tcggaggagt ccagcgagtg accattactg acgccagacg ccgcacctgc 15780 ccctacgttt acaaggccct gggcatagtc tcgccgcgcg tcctatcgag ccgcactttt 15840 tgagcaagca tgtccatcct tatatcgccc agcaataaca caggctgggg cctgcgcttc 15900 ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc aacacccagt gcgcgtgcgc 15960 gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc gcactgggcg caccaccgtc 16020 gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact acacgcccac gccgccacca 16080 gtgtccacag tggacgcggc cattcagacc gtggtgcgcg gagcccggcg ctatgctaaa 16140 atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc gccgacccgg cactgccgcc 16200 caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca ccggccgacg ggcggccatg 16260 cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc cccccaggtc caggcgacga 16320 gcggccgccg cagcagccgc ggccattagt gctatgactc agggtcgcag gggcaacgtg 16380 tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg tgcgcacccg ccccccgcgc 16440 aactagattg caagaaaaaa ctacttagac tcgtactgtt gtatgtatcc agcggcggcg 16500 gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag agatgctcca ggtcatcgcg 16560 ccggagatct atggcccccc gaagaaggaa gagcaggatt acaagccccg aaagctaaag 16620 cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg acgacgaggt ggaactgctg 16680 cacgctaccg cgcccaggcg acgggtacag tggaaaggtc gacgcgtaaa acgtgttttg 16740 cgacccggca ccaccgtagt ctttacgccc ggtgagcgct ccacccgcac ctacaagcgc 16800 gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc aggccaacga gcgcctcggg 16860 gagtttgcct acggaaagcg gcataaggac atgctggcgt tgccgctgga cgagggcaac 16920 ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc tgcccgcgct tgcaccgtcc 16980 gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg cacccaccgt gcagctgatg 17040 gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa tgaccgtgga acctgggctg 17100 gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc cgggactggg cgtgcagacc 17160 gtggacgttc agatacccac taccagtagc accagtattg ccaccgccac agagggcatg 17220 gagacacaaa cgtccccggt tgcctcagcg gtggcggatg ccgcggtgca ggcggtcgct 17280 gcggccgcgt ccaagacctc tacggaggtg caaacggacc cgtggatgtt tcgcgtttca 17340 gccccccggc gcccgcgcgg ttcgaggaag tacggcgccg ccagcgcgct actgcccgaa 17400 tatgccctac atccttccat tgcgcctacc cccggctatc gtggctacac ctaccgcccc 17460 agaagacgag caactacccg acgccgaacc accactggaa cccgccgccg ccgtcgccgt 17520 cgccagcccg tgctggcccc gatttccgtg cgcagggtgg ctcgcgaagg aggcaggacc 17580 ctggtgctgc caacagcgcg ctaccacccc agcatcgttt aaaagccggt ctttgtggtt 17640 cttgcagata tggccctcac ctgccgcctc cgtttcccgg tgccgggatt ccgaggaaga 17700 atgcaccgta ggaggggcat ggccggccac ggcctgacgg gcggcatgcg tcgtgcgcac 17760 caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg gtatcctgcc cctccttatt 17820 ccactgatcg ccgcggcgat tggcgccgtg cccggaattg catccgtggc cttgcaggcg 17880 cagagacact gattaaaaac aagttgcatg tggaaaaatc aaaataaaaa gtctggactc 17940 tcacgctcgc ttggtcctgt aactattttg tagaatggaa gacatcaact ttgcgtctct 18000 ggccccgcga cacggctcgc gcccgttcat gggaaactgg caagatatcg gcaccagcaa 18060 tatgagcggt ggcgccttca gctggggctc gctgtggagc ggcattaaaa atttcggttc 18120 caccgttaag aactatggca gcaaggcctg gaacagcagc acaggccaga tgctgaggga 18180 taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat ggcctggcct ctggcattag 18240 cggggtggtg gacctggcca accaggcagt gcaaaataag attaacagta agcttgatcc 18300 ccgccctccc gtagaggagc ctccaccggc cgtggagaca gtgtctccag aggggcgtgg 18360 cgaaaagcgt ccgcgccccg acagggaaga aactctggtg acgcaaatag acgagcctcc 18420 ctcgtacgag gaggcactaa agcaaggcct gcccaccacc cgtcccatcg cgcccatggc 18480 taccggagtg ctgggccagc acacacccgt aacgctggac ctgcctcccc ccgccgacac 18540 ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt gtaacccgtc ctagccgcgc 18600 gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg cccgtagcca gtggcaactg 18660 gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa tccctgaagc gccgacgatg 18720 cttctgaata gctaacgtgt cgtatgtgtg tcatgtatgc gtccatgtcg ccgccagagg 18780 agctgctgag ccgccgcgcg cccgctttcc aagatggcta ccccttcgat gatgccgcag 18840 tggtcttaca tgcacatctc gggccaggac gcctcggagt acctgagccc cgggctggtg 18900 cagtttgccc gcgccaccga gacgtacttc agcctgaata acaagtttag aaaccccacg 18960 gtggcgccta cgcacgacgt gaccacagac cggtcccagc gtttgacgct gcggttcatc 19020 cctgtggacc gtgaggatac tgcgtactcg tacaaggcgc ggttcaccct agctgtgggt 19080 gataaccgtg tgctggacat ggcttccacg tactttgaca tccgcggcgt gctggacagg 19140 ggccctactt ttaagcccta ctctggcact gcctacaacg ccctggctcc caagggtgcc 19200 ccaaatcctt gcgaatggga tgaagctgct actgctcttg aaataaacct agaagaagag 19260 gacgatgaca acgaagacga agtagacgag caagctgagc agcaaaaaac tcacgtattt 19320 gggcaggcgc cttattctgg tataaatatt acaaaggagg gtattcaaat aggtgtcgaa 19380 ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg aacctcaaat aggagaatct 19440 cagtggtacg aaactgaaat taatcatgca gctgggagag tccttaaaaa gactacccca 19500 atgaaaccat gttacggttc atatgcaaaa cccacaaatg aaaatggagg gcaaggcatt 19560 cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg aaatgcaatt tttctcaact 19620 actgaggcga ccgcaggcaa tggtgataac ttgactccta aagtggtatt gtacagtgaa 19680 gatgtagata tagaaacccc agacactcat atttcttaca tgcccactat taaggaaggt 19740 aactcacgag aactaatggg ccaacaatct atgcccaaca ggcctaatta cattgctttt 19800 agggacaatt ttattggtct aatgtattac aacagcacgg gtaatatggg tgttctggcg 19860 ggccaagcat cgcagttgaa tgctgttgta gatttgcaag acagaaacac agagctttca 19920 taccagcttt tgcttgattc cattggtgat agaaccaggt acttttctat gtggaatcag 19980 gctgttgaca gctatgatcc agatgttaga attattgaaa atcatggaac tgaagatgaa 20040 cttccaaatt actgctttcc actgggaggt gtgattaata cagagactct taccaaggta 20100 aaacctaaaa caggtcagga aaatggatgg gaaaaagatg ctacagaatt ttcagataaa 20160 aatgaaataa gagttggaaa taattttgcc atggaaatca atctaaatgc caacctgtgg 20220 agaaatttcc tgtactccaa catagcgctg tatttgcccg acaagctaaa gtacagtcct 20280 tccaacgtaa aaatttctga taacccaaac acctacgact acatgaacaa gcgagtggtg 20340 gctcccgggt tagtggactg ctacattaac cttggagcac gctggtccct tgactatatg 20400 gacaacgtca acccatttaa ccaccaccgc aatgctggcc tgcgctaccg ctcaatgttg 20460 ctgggcaatg gtcgctatgt gcccttccac atccaggtgc ctcagaagtt ctttgccatt 20520 aaaaacctcc ttctcctgcc gggctcatac acctacgagt ggaacttcag gaaggatgtt 20580 aacatggttc tgcagagctc cctaggaaat gacctaaggg ttgacggagc cagcattaag 20640 tttgatagca tttgccttta cgccaccttc ttccccatgg cccacaacac cgcctccacg 20700 cttgaggcca tgcttagaaa cgacaccaac gaccagtcct ttaacgacta tctctccgcc 20760 gccaacatgc tctaccctat acccgccaac gctaccaacg tgcccatatc catcccctcc 20820 cgcaactggg cggctttccg cggctgggcc ttcacgcgcc ttaagactaa ggaaacccca 20880 tcactgggct cgggctacga cccttattac acctactctg gctctatacc ctacctagat 20940 ggaacctttt acctcaacca cacctttaag aaggtggcca ttacctttga ctcttctgtc 21000 agctggcctg gcaatgaccg cctgcttacc cccaacgagt ttgaaattaa gcgctcagtt 21060 gacggggagg gttacaacgt tgcccagtgt aacatgacca aagactggtt cctggtacaa 21120 atgctagcta actacaacat tggctaccag ggcttctata tcccagagag ctacaaggac 21180 cgcatgtact ccttctttag aaacttccag cccatgagcc gtcaggtggt ggatgatact 21240 aaatacaagg actaccaaca ggtgggcatc ctacaccaac acaacaactc tggatttgtt 21300 ggctaccttg cccccaccat gcgcgaagga caggcctacc ctgctaactt cccctatccg 21360 cttataggca agaccgcagt tgacagcatt acccagaaaa agtttctttg cgatcgcacc 21420 ctttggcgca tcccattctc cagtaacttt atgtccatgg gcgcactcac agacctgggc 21480 caaaaccttc tctacgccaa ctccgcccac gcgctagaca tgacttttga ggtggatccc 21540 atggacgagc ccacccttct ttatgttttg tttgaagtct ttgacgtggt ccgtgtgcac 21600 cggccgcacc gcggcgtcat cgaaaccgtg tacctgcgca cgcccttctc ggccggcaac 21660 gccacaacat aaagaagcaa gcaacatcaa caacagctgc cgccatgggc tccagtgagc 21720 aggaactgaa agccattgtc aaagatcttg gttgtgggcc atattttttg ggcacctatg 21780 acaagcgctt tccaggcttt gtttctccac acaagctcgc ctgcgccata gtcaatacgg 21840 ccggtcgcga gactgggggc gtacactgga tggcctttgc ctggaacccg cactcaaaaa 21900 catgctacct ctttgagccc tttggctttt ctgaccagcg actcaagcag gtttaccagt 21960 ttgagtacga gtcactcctg cgccgtagcg ccattgcttc ttcccccgac cgctgtataa 22020 cgctggaaaa gtccacccaa agcgtacagg ggcccaactc ggccgcctgt ggactattct 22080 gctgcatgtt tctccacgcc tttgccaact ggccccaaac tcccatggat cacaacccca 22140 ccatgaacct tattaccggg gtacccaact ccatgctcaa cagtccccag gtacagccca 22200 ccctgcgtcg caaccaggaa cagctctaca gcttcctgga gcgccactcg ccctacttcc 22260 gcagccacag tgcgcagatt aggagcgcca cttctttttg tcacttgaaa aacatgtaaa 22320 aataatgtac tagagacact ttcaataaag gcaaatgctt ttatttgtac actctcgggt 22380 gattatttac ccccaccctt gccgtctgcg ccgtttaaaa atcaaagggg ttctgccgcg 22440 catcgctatg cgccactggc agggacacgt tgcgatactg gtgtttagtg ctccacttaa 22500 actcaggcac aaccatccgc ggcagctcgg tgaagttttc actccacagg ctgcgcacca 22560 tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa gtcgcagttg gggcctccgc 22620 cctgcgcgcg cgagttgcga tacacagggt tgcagcactg gaacactatc agcgccgggt 22680 ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc cgcgtccagg tcctccgcgt 22740 tgctcagggc gaacggagtc aactttggta gctgccttcc caaaaagggc gcgtgcccag 22800 gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg accgtgcccg gtctgggcgt 22860 taggatacag cgcctgcata aaagccttga tctgcttaaa agccacctga gcctttgcgc 22920 cttcagagaa gaacatgccg caagacttgc cggaaaactg attggccgga caggccgcgt 22980 cgtgcacgca gcaccttgcg tcggtgttgg agatctgcac cacatttcgg ccccaccggt 23040 tcttcacgat cttggccttg ctagactgct ccttcagcgc gcgctgcccg ttttcgctcg 23100 tcacatccat ttcaatcacg tgctccttat ttatcataat gcttccgtgt agacacttaa 23160 gctcgccttc gatctcagcg cagcggtgca gccacaacgc gcagcccgtg ggctcgtgat 23220 gcttgtaggt cacctctgca aacgactgca ggtacgcctg caggaatcgc cccatcatcg 23280 tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc gcggtgctcc tcgttcagcc 23340 aggtcttgca tacggccgcc agagcttcca cttggtcagg cagtagtttg aagttcgcct 23400 ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg cgcagcctcc atgcccttct 23460 cccacgcaga cacgatcggc acactcagcg ggttcatcac cgtaatttca ctttccgctt 23520 cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg cgccactggg tcgtcttcat 23580 tcagccgccg cactgtgcgc ttacctcctt tgccatgctt gattagcacc ggtgggttgc 23640 tgaaacccac catttgtagc gccacatctt ctctttcttc ctcgctgtcc acgattacct 23700 ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt ctttttcttc ttgggcgcaa 23760 tggccaaatc cgccgccgag gtcgatggcc gcgggctggg tgtgcgcggc accagcgcgt 23820 cttgtgatga gtcttcctcg tcctcggact cgatacgccg cctcatccgc ttttttgggg 23880 gcgcccgggg aggcggcggc gacggggacg gggacgacac gtcctccatg gttgggggac 23940 gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg ctgctcctct tcccgactgg 24000 ccatttcctt ctcctatagg cagaaaaaga tcatggagtc agtcgagaag aaggacagcc 24060 taaccgcccc ctctgagttc gccaccaccg cctccaccga tgccgccaac gcgcctacca 24120 ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt gattatcgag caggacccag 24180 gttttgtaag cgaagacgac gaggaccgct cagtaccaac agaggataaa aagcaagacc 24240 aggacaacgc agaggcaaac gaggaacaag tcgggcgggg ggacgaaagg catggcgact 24300 acctagatgt gggagacgac gtgctgttga agcatctgca gcgccagtgc gccattatct 24360 gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat agcggatgtc agccttgcct 24420 acgaacgcca cctattctca ccgcgcgtac cccccaaacg ccaagaaaac ggcacatgcg 24480 agcccaaccc gcgcctcaac ttctaccccg tatttgccgt gccagaggtg cttgccacct 24540 atcacatctt tttccaaaac tgcaagatac ccctatcctg ccgtgccaac cgcagccgag 24600 cggacaagca gctggccttg cggcagggcg ctgtcatacc tgatatcgcc tcgctcaacg 24660 aagtgccaaa aatctttgag ggtcttggac gcgacgagaa gcgcgcggca aacgctctgc 24720 aacaggaaaa cagcgaaaat gaaagtcact ctggagtgtt ggtggaactc gagggtgaca 24780 acgcgcgcct agccgtacta aaacgcagca tcgaggtcac ccactttgcc tacccggcac 24840 ttaacctacc ccccaaggtc atgagcacag tcatgagtga gctgatcgtg cgccgtgcgc 24900 agcccctgga gagggatgca aatttgcaag aacaaacaga ggagggccta cccgcagttg 24960 gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc tgccgacttg gaggagcgac 25020 gcaaactaat gatggccgca gtgctcgtta ccgtggagct tgagtgcatg cagcggttct 25080 ttgctgaccc ggagatgcag cgcaagctag aggaaacatt gcactacacc tttcgacagg 25140 gctacgtacg ccaggcctgc aagatctcca acgtggagct ctgcaacctg gtctcctacc 25200 ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct tcattccacg ctcaagggcg 25260 aggcgcgccg cgactacgtc cgcgactgcg tttacttatt tctatgctac acctggcaga 25320 cggccatggg cgtttggcag cagtgcttgg aggagtgcaa cctcaaggag ctgcagaaac 25380 tgctaaagca aaacttgaag gacctatgga cggccttcaa cgagcgctcc gtggccgcgc 25440 acctggcgga catcattttc cccgaacgcc tgcttaaaac cctgcaacag ggtctgccag 25500 acttcaccag tcaaagcatg ttgcagaact ttaggaactt tatcctagag cgctcaggaa 25560 tcttgcccgc cacctgctgt gcacttccta gcgactttgt gcccattaag taccgcgaat 25620 gccctccgcc gctttggggc cactgctacc ttctgcagct agccaactac cttgcctacc 25680 actctgacat aatggaagac gtgagcggtg acggtctact ggagtgtcac tgtcgctgca 25740 acctatgcac cccgcaccgc tccctggttt gcaattcgca gctgcttaac gaaagtcaaa 25800 ttatcggtac ctttgagctg cagggtccct cgcctgacga aaagtccgcg gctccggggt 25860 tgaaactcac tccggggctg tggacgtcgg cttaccttcg caaatttgta cctgaggact 25920 accacgccca cgagattagg ttctacgaag accaatcccg cccgccaaat gcggagctta 25980 ccgcctgcgt cattacccag ggccacattc ttggccaatt gcaagccatc aacaaagccc 26040 gccaagagtt tctgctacga aagggacggg gggtttactt ggacccccag tccggcgagg 26100 agctcaaccc aatccccccg ccgccgcagc cctatcagca gcagccgcgg gcccttgctt 26160 cccaggatgg cacccaaaaa gaagctgcag ctgccgccgc cacccacgga cgaggaggaa 26220 tactgggaca gtcaggcaga ggaggttttg gacgaggagg aggaggacat gatggaagac 26280 tgggagagcc tagacgagga agcttccgag gtcgaagagg tgtcagacga aacaccgtca 26340 ccctcggtcg cattcccctc gccggcgccc cagaaatcgg caaccggttc cagcatggct 26400 acaacctccg ctcctcaggc gccgccggca ctgcccgttc gccgacccaa ccgtagatgg 26460 gacaccactg gaaccagggc cggtaagtcc aagcagccgc cgccgttagc ccaagagcaa 26520 caacagcgcc aaggctaccg ctcatggcgc gggcacaaga acgccatagt tgcttgcttg 26580 caagactgtg ggggcaacat ctccttcgcc cgccgctttc ttctctacca tcacggcgtg 26640 gccttccccc gtaacatcct gcattactac cgtcatctct acagcccata ctgcaccggc 26700 ggcagcggca gcggcagcaa cagcagcggc cacacagaag caaaggcgac cggatagcaa 26760 gactctgaca aagcccaaga aatccacagc ggcggcagca gcaggaggag gagcgctgcg 26820 tctggcgccc aacgaacccg tatcgacccg cgagcttaga aacaggattt ttcccactct 26880 gtatgctata tttcaacaga gcaggggcca agaacaagag ctgaaaataa aaaacaggtc 26940 tctgcgatcc ctcacccgca gctgcctgta tcacaaaagc gaagatcagc ttcggcgcac 27000 gctggaagac gcggaggctc tcttcagtaa atactgcgcg ctgactctta aggactagtt 27060 tcgcgccctt tctcaaattt aagcgcgaaa actacgtcat ctccagcggc cacacccggc 27120 gccagcacct gtcgtcagcg ccatttatga gcaaggaaat tcccacgccc tacatgtgga 27180 gttaccagcc acaaatggga cttgcggctg gagctgccca agactactca acccgaataa 27240 actacatgag cgcgggaccc cacatgatat cccgggtcaa cggaatacgc gcccaccgaa 27300 accgaattct cctggaacag gcggctatta ccaccacacc tcgtaataac cttaatcccc 27360 gtagttggcc cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc 27420 ccagagacgc ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct 27480 ttcgtcacag ggtgcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag 27540 gtattcagct caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat 27600 ttcagatcgg cggcgccggc cgctcttcat tcacgcctcg tcaggcaatc ctaactctgc 27660 agacctcgtc ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt 27720 ttgtgccatc ggtctacttt aaccccttct cgggacctcc cggccactat ccggatcaat 27780 ttattcctaa ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg 27840 gagaggcaga gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg 27900 cccgcgactc cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg 27960 cgcacggcgt ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta 28020 cccagcgccc cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca 28080 actgtcctaa ccctggatta catcaagatc tttgttgcca tctctgtgct gagtataata 28140 aatacagaaa ttaaaatata ctggggctcc tatcgccatc ctgtaaacgc caccgtcttc 28200 acccgcccaa gcaaaccaag gcgaacctta cctggtactt ttaacatctc tccctctgtg 28260 atttacaaca gtttcaaccc agacggagtg agtctacgag agaacctctc cgagctcagc 28320 tactccatca gaaaaaacac caccctcctt acctgccggg aacgtacgag tgcgtcaccg 28380 gccgctgcac cacacctacc gcctgaccgt aaaccagact ttttccggac agacctcaat 28440 aactctgttt accagaacag gaggtgagct tagaaaaccc ttagggtatt aggccaaagg 28500 cgcagctact gtggggttta tgaacaattc aagcaactct acgggctatt ctaattcagg 28560 tttctctaga atcggggttg gggttattct ctgtcttgtg attctcttta ttcttatact 28620 aacgcttctc tgcctaaggc tcgccgcctg ctgtgtgcac atttgcattt attgtcagct 28680 ttttaaacgc tggggtcgcc acccaagatg attaggtaca taatcctagg tttactcacc 28740 cttgcgtcag cccacggtac cacccaaaag gtggatttta aggagccagc ctgtaatgtt 28800 acattcgcag ctgaagctaa tgagtgcacc actcttataa aatgcaccac agaacatgaa 28860 aagctgctta ttcgccacaa aaacaaaatt ggcaagtatg ctgtttatgc tatttggcag 28920 ccaggtgaca ctacagagta taatgttaca gttttccagg gtaaaagtca taaaactttt 28980 atgtatactt ttccatttta tgaaatgtgc gacattacca tgtacatgag caaacagtat 29040 aagttgtggc ccccacaaaa ttgtgtggaa aacactggca ctttctgctg cactgctatg 29100 ctaattacag tgctcgcttt ggtctgtacc ctactctata ttaaatacaa aagcagacgc 29160 agctttattg aggaaaagaa aatgccttaa tttactaagt tacaaagcta atgtcaccac 29220 taactgcttt actcgctgct tgcaaaacaa attcaaaaag ttagcattat aattagaata 29280 ggatttaaac cccccggtca tttcctgctc aataccattc ccctgaacaa ttgactctat 29340 gtgggatatg ctccagcgct acaaccttga agtcaggctt cctggatgtc agcatctgac 29400 tttggccagc acctgtcccg cggatttgtt ccagtccaac tacagcgacc caccctaaca 29460 gagatgacca acacaaccaa cgcggccgcc gctaccggac ttacatctac cacaaataca 29520 ccccaagttt ctgcctttgt caataactgg gataacttgg gcatgtggtg gttctccata 29580 gcgcttatgt ttgtatgcct tattattatg tggctcatct gctgcctaaa gcgcaaacgc 29640 gcccgaccac ccatctatag tcccatcatt gtgctacacc caaacaatga tggaatccat 29700 agattggacg gactgaaaca catgttcttt tctcttacag tatgattaaa tgagacatga 29760 ttcctcgagt ttttatatta ctgacccttg ttgcgctttt ttgtgcgtgc tccacattgg 29820 ctgcggtttc tcacatcgaa gtagactgca ttccagcctt cacagtctat ttgctttacg 29880 gatttgtcac cctcacgctc atctgcagcc tcatcactgt ggtcatcgcc tttatccagt 29940 gcattgactg ggtctgtgtg cgctttgcat atctcagaca ccatccccag tacagggaca 30000 ggactatagc tgagcttctt agaattcttt aattatgaaa tttactgtga cttttctgct 30060 gattatttgc accctatctg cgttttgttc cccgacctcc aagcctcaaa gacatatatc 30120 atgcagattc actcgtatat ggaatattcc aagttgctac aatgaaaaaa gcgatctttc 30180 cgaagcctgg ttatatgcaa tcatctctgt tatggtgttc tgcagtacca tcttagccct 30240 agctatatat ccctaccttg acattggctg gaacgcaata gatgccatga accacccaac 30300 tttccccgcg cccgctatgc ttccactgca acaagttgtt gccggcggct ttgtcccagc 30360 caatcagcct cgcccacctt ctcccacccc cactgaaatc agctacttta atctaacagg 30420 aggagatgac tgacacccta gatctagaaa tggacggaat tattacagag cagcgcctgc 30480 tagaaagacg cagggcagcg gccgagcaac agcgcatgaa tcaagagctc caagacatgg 30540 ttaacttgca ccagtgcaaa aggggtatct tttgtctggt aaagcaggcc aaagtcacct 30600 acgacagtaa taccaccgga caccgcctta gctacaagtt gccaaccaag cgtcagaaat 30660 tggtggtcat ggtgggagaa aagcccatta ccataactca gcactcggta gaaaccgaag 30720 gctgcattca ctcaccttgt caaggacctg aggatctctg cacccttatt aagaccctgt 30780 gcggtctcaa agatcttatt ccctttaact aataaaaaaa aataataaag catcacttac 30840 ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc 30900 cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg 30960 tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag 31020 cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt 31080 cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt 31140 ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt 31200 gcgctcaaaa tgggcaacgg cctctctctg gacgaggccg gcaaccttac ctcccaaaat 31260 gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct 31320 gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc 31380 gcgggcaaca cactcaccat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt 31440 agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca 31500 ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact 31560 actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa 31620 ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac tttgaccgta 31680 gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc 31740 ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat 31800 tctcaaaaca gacgccttat acttgatgtt agttatccgt ttgatgctca aaaccaacta 31860 aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac 31920 tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac 31980 ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat 32040 gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc 32100 catggcctag aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt 32160 tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg 32220 accacaccag ctccatctcc taactgtaga ctaaatgcag agaaagatgc taaactcact 32280 ttggtcttaa caaaatgtgg cagtcaaata cttgctacag tttcagtttt ggctgttaaa 32340 ggcagtttgg ctccaatatc tggaacagtt caaagtgctc atcttattat aagatttgac 32400 gaaaatggag tgctactaaa caattccttc ctggacccag aatattggaa ctttagaaat 32460 ggagatctta ctgaaggcac agcctataca aacgctgttg gatttatgcc taacctatca 32520 gcttatccaa aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca agtttactta 32580 aacggagaca aaactaaacc tgtaacacta accattacac taaacggtac acaggaaaca 32640 ggagacacaa ctccaagtgc atactctatg tcattttcat gggactggtc tggccacaac 32700 tacattaatg aaatatttgc cacatcctct tacacttttt catacattgc ccaagaataa 32760 agaatcgttt gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcgaatca 32820 tttttcattc agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa 32880 tcaaacctac atgggggtag agtcataatc gtgcatcagg atagggcggt ggtgctgcag 32940 cagcgcgcga ataaactgct gccgccgccg ctccgtcctg caggaataca acatggcagt 33000 ggtctcctca gcgatgattc gcaccgcccg cagcataagg cgccttgtcc tccgggcaca 33060 gcagcgcacc ctgatctcac ttaaatcagc acagtaactg cagcacagca ccacaatatt 33120 gttcaaaatc ccacagtgca aggcgctgta tccaaagctc atggcgggga ccacagaacc 33180 cacgtggcca tcataccaca agcgcaggta gattaagtgg cgacccctca taaacacgct 33240 ggacataaac attacctctt ttggcatgtt gtaattcacc acctcccggt accatataaa 33300 cctctgatta aacatggcgc catccaccac catcctaaac cagctggcca aaacctgccc 33360 gccggctata cactgcaggg aaccgggact ggaacaatga cagtggagag cccaggactc 33420 gtaaccatgg atcatcatgc tcgtcatgat atcaatgttg gcacaacaca ggcacacgtg 33480 catacacttc ctcaggatta caagctcctc ccgcgttaga accatatccc agggaacaac 33540 ccattcctga atcagcgtaa atcccacact gcagggaaga cctcgcacgt aactcacgtt 33600 gtgcattgtc aaagtgttac attcgggcag cagcggatga tcctccagta tggtagcgcg 33660 ggtttctgtc tcaaaaggag gtagacgatc cctactgtac ggagtgcgcc gagacaaccg 33720 agatcgtgtt ggtcgtagtg tcatgccaaa tggaacgccg gacgtagtca tatttcctga 33780 agcaaaacca ggtgcgggcg tgacaaacag atctgcgtct ccggtctcgc cgcttagatc 33840 gctctgtgta gtagttgtag tatatccact ctctcaaagc atccaggcgc cccctggctt 33900 cgggttctat gtaaactcct tcatgcgccg ctgccctgat aacatccacc accgcagaat 33960 aagccacacc cagccaacct acacattcgt tctgcgagtc acacacggga ggagcgggaa 34020 gagctggaag aaccatgttt ttttttttat tccaaaagat tatccaaaac ctcaaaatga 34080 agatctatta agtgaacgcg ctcccctccg gtggcgtggt caaactctac agccaaagaa 34140 cagataatgg catttgtaag atgttgcaca atggcttcca aaaggcaaac ggccctcacg 34200 tccaagtgga cgtaaaggct aaacccttca gggtgaatct cctctataaa cattccagca 34260 ccttcaacca tgcccaaata attctcatct cgccaccttc tcaatatatc tctaagcaaa 34320 tcccgaatat taagtccggc cattgtaaaa atctgctcca gagcgccctc caccttcagc 34380 ctcaagcagc gaatcatgat tgcaaaaatt caggttcctc acagacctgt ataagattca 34440 aaagcggaac attaacaaaa ataccgcgat cccgtaggtc ccttcgcagg gccagctgaa 34500 cataatcgtg caggtctgca cggaccagcg cggccacttc cccgccagga accatgacaa 34560 aagaacccac actgattatg acacgcatac tcggagctat gctaaccagc gtagccccga 34620 tgtaagcttg ttgcatgggc ggcgatataa aatgcaaggt gctgctcaaa aaatcaggca 34680 aagcctcgcg caaaaaagaa agcacatcgt agtcatgctc atgcagataa aggcaggtaa 34740 gctccggaac caccacagaa aaagacacca tttttctctc aaacataaca gtcagcctta 34800 ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac acggcaccag ctcaatcagt 34860 cacagtgtaa aaaagggcca agtgcagagc gagtatatat aggactaaaa aatgacgtaa 34920 cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg aacctacgcc cagaaacgaa 34980 agccaaaaaa cccacaactt cctcaaatcg tcacttccgt tttcccacgt tacgtcactt 35040 cccattttaa gaaaactaca attcccaaca catacaagtt actccgccct aaaacctacg 35100 tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac tccaccccct cattatcata 35160 ttggcttcaa tccaaaataa ggtatattat tgatgatg 35198 <210> 17 <211> 35941 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO238) <400> 17 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgcat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttaccgg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcaagtca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaactcac agaaccctag tattcaacct 32940 gccacctccc tcccaacaca cagagtacac agtcctttct ccccggctgg ccttaaaaag 33000 catcatatca tgggtaacag acatattctt aggtgttata ttccacacgg tttcctgtcg 33060 agccaaacgc tcatcagtga tattaataaa ctccccgggc agctcactta agttcatgtc 33120 gctgtccagc tgctgagcca caggctgctg tccaacttgc ggttgcttaa cgggcggcga 33180 aggagaagtc cacgcctaca tgggggtaga gtcataatcg tgcatcagga tagggcggtg 33240 gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc tccgtcctgc aggaatacaa 33300 catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc gccttgtcct 33360 ccgggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc agcacagcac 33420 cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca tggcggggac 33480 cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc gacccctcat 33540 aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca cctcccggta 33600 ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc agctggccaa 33660 aacctgcccg ccggctatac actgcaggga accgggactg gaacaatgac agtggagagc 33720 ccaggactcg taaccatgga tcatcatgct cgtcatgata tcaatgttgg cacaacacag 33780 gcacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa ccatatccca 33840 gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac ctcgcacgta 33900 actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat cctccagtat 33960 ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg gagtgcgccg 34020 agacaaccga gatcgtgttg gtcgtagtgt catgccaaat ggaacgccgg acgtagtcat 34080 atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc cggtctcgcc 34140 gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca tccaggcgcc 34200 ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata acatccacca 34260 ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca cacacgggag 34320 gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt atccaaaacc 34380 tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc aaactctaca 34440 gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa aaggcaaacg 34500 gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc ctctataaac 34560 attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct caatatatct 34620 ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag agcgccctcc 34680 accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca cagacctgta 34740 taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc cttcgcaggg 34800 ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc ccgccaggaa 34860 ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg ctaaccagcg 34920 tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg ctgctcaaaa 34980 aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta gtcatgctca tgcagataaa 35040 ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca aacatgtctg 35100 cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat tagaagcctg 35160 tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca tgccggcgtg 35220 accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct cggtcatgtc 35280 cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg tcagtgctaa 35340 aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca acattacagc 35400 ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac ctgaaaaacc 35460 ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg cttccacagc 35520 ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa aacaccactc 35580 gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag agcgagtata 35640 tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag aaaaccgcac 35700 gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa tcgtcacttc 35760 cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca acacatacaa 35820 gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg ccacgtcaca 35880 aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat tattgatgat 35940 g 35941 <210> 18 <211> 35662 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO293) <400> 18 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgcat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttaccgg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcgaatca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaacctac atgggggtag agtcataatc 32940 gtgcatcagg atagggcggt ggtgctgcag cagcgcgcga ataaactgct gccgccgccg 33000 ctccgtcctg caggaataca acatggcagt ggtctcctca gcgatgattc gcaccgcccg 33060 cagcataagg cgccttgtcc tccgggcaca gcagcgcacc ctgatctcac ttaaatcagc 33120 acagtaactg cagcacagca ccacaatatt gttcaaaatc ccacagtgca aggcgctgta 33180 tccaaagctc atggcgggga ccacagaacc cacgtggcca tcataccaca agcgcaggta 33240 gattaagtgg cgacccctca taaacacgct ggacataaac attacctctt ttggcatgtt 33300 gtaattcacc acctcccggt accatataaa cctctgatta aacatggcgc catccaccac 33360 catcctaaac cagctggcca aaacctgccc gccggctata cactgcaggg aaccgggact 33420 ggaacaatga cagtggagag cccaggactc gtaaccatgg atcatcatgc tcgtcatgat 33480 atcaatgttg gcacaacaca ggcacacgtg catacacttc ctcaggatta caagctcctc 33540 ccgcgttaga accatatccc agggaacaac ccattcctga atcagcgtaa atcccacact 33600 gcagggaaga cctcgcacgt aactcacgtt gtgcattgtc aaagtgttac attcgggcag 33660 cagcggatga tcctccagta tggtagcgcg ggtttctgtc tcaaaaggag gtagacgatc 33720 cctactgtac ggagtgcgcc gagacaaccg agatcgtgtt ggtcgtagtg tcatgccaaa 33780 tggaacgccg gacgtagtca tatttcctga agcaaaacca ggtgcgggcg tgacaaacag 33840 atctgcgtct ccggtctcgc cgcttagatc gctctgtgta gtagttgtag tatatccact 33900 ctctcaaagc atccaggcgc cccctggctt cgggttctat gtaaactcct tcatgcgccg 33960 ctgccctgat aacatccacc accgcagaat aagccacacc cagccaacct acacattcgt 34020 tctgcgagtc acacacggga ggagcgggaa gagctggaag aaccatgttt ttttttttat 34080 tccaaaagat tatccaaaac ctcaaaatga agatctatta agtgaacgcg ctcccctccg 34140 gtggcgtggt caaactctac agccaaagaa cagataatgg catttgtaag atgttgcaca 34200 atggcttcca aaaggcaaac ggccctcacg tccaagtgga cgtaaaggct aaacccttca 34260 gggtgaatct cctctataaa cattccagca ccttcaacca tgcccaaata attctcatct 34320 cgccaccttc tcaatatatc tctaagcaaa tcccgaatat taagtccggc cattgtaaaa 34380 atctgctcca gagcgccctc caccttcagc ctcaagcagc gaatcatgat tgcaaaaatt 34440 caggttcctc acagacctgt ataagattca aaagcggaac attaacaaaa ataccgcgat 34500 cccgtaggtc ccttcgcagg gccagctgaa cataatcgtg caggtctgca cggaccagcg 34560 cggccacttc cccgccagga accatgacaa aagaacccac actgattatg acacgcatac 34620 tcggagctat gctaaccagc gtagccccga tgtaagcttg ttgcatgggc ggcgatataa 34680 aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg caaaaaagaa agcacatcgt 34740 agtcatgctc atgcagataa aggcaggtaa gctccggaac caccacagaa aaagacacca 34800 tttttctctc aaacatgtct gcgggtttct gcataaacac aaaataaaat aacaaaaaaa 34860 catttaaaca ttagaagcct gtcttacaac aggaaaaaca acccttataa gcataagacg 34920 gactacggcc atgccggcgt gaccgtaaaa aaactggtca ccgtgattaa aaagcaccac 34980 cgacagctcc tcggtcatgt ccggagtcat aatgtaagac tcggtaaaca catcaggttg 35040 attcacatcg gtcagtgcta aaaagcgacc gaaatagccc gggggaatac atacccgcag 35100 gcgtagagac aacattacag cccccatagg aggtataaca aaattaatag gagagaaaaa 35160 cacataaaca cctgaaaaac cctcctgcct aggcaaaata gcaccctccc gctccagaac 35220 aacatacagc gcttccacag cggcagccat aacagtcagc cttaccagta aaaaagaaaa 35280 cctattaaaa aaacaccact cgacacggca ccagctcaat cagtcacagt gtaaaaaagg 35340 gccaagtgca gagcgagtat atataggact aaaaaatgac gtaacggtta aagtccacaa 35400 aaaacaccca gaaaaccgca cgcgaaccta cgcccagaaa cgaaagccaa aaaacccaca 35460 acttcctcaa atcgtcactt ccgttttccc acgttacgtc acttcccatt ttaagaaaac 35520 tacaattccc aacacataca agttactccg ccctaaaacc tacgtcaccc gccccgttcc 35580 cacgccccgc gccacgtcac aaactccacc ccctcattat catattggct tcaatccaaa 35640 ataaggtata ttattgatga tg 35662 <210> 19 <211> 35653 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO294) <400> 19 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgcat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttaccgg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcgaatca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaacctac atgggggtag agtcataatc 32940 gtgcatcagg atagggcggt ggtgctgcag cagcgcgcga ataaactgct gccgccgccg 33000 ctccgtcctg caggaataca acatggcagt ggtctcctca gcgatgattc gcaccgcccg 33060 cagcataagg cgccttgtcc tccgggcaca gcagcgcacc ctgatctcac ttaaatcagc 33120 acagtaactg cagcacagca ccacaatatt gttcaaaatc ccacagtgca aggcgctgta 33180 tccaaagctc atggcgggga ccacagaacc cacgtggcca tcataccaca agcgcaggta 33240 gattaagtgg cgacccctca taaacacgct ggacataaac attacctctt ttggcatgtt 33300 gtaattcacc acctcccggt accatataaa cctctgatta aacatggcgc catccaccac 33360 catcctaaac cagctggcca aaacctgccc gccggctata cactgcaggg aaccgggact 33420 ggaacaatga cagtggagag cccaggactc gtaaccatgg atcatcatgc tcgtcatgat 33480 atcaatgttg gcacaacaca ggcacacgtg catacacttc ctcaggatta caagctcctc 33540 ccgcgttaga accatatccc agggaacaac ccattcctga atcagcgtaa atcccacact 33600 gcagggaaga cctcgcacgt aactcacgtt gtgcattgtc aaagtgttac attcgggcag 33660 cagcggatga tcctccagta tggtagcgcg ggtttctgtc tcaaaaggag gtagacgatc 33720 cctactgtac ggagtgcgcc gagacaaccg agatcgtgtt ggtcgtagtg tcatgccaaa 33780 tggaacgccg gacgtagtca tatttcctga agcaaaacca ggtgcgggcg tgacaaacag 33840 atctgcgtct ccggtctcgc cgcttagatc gctctgtgta gtagttgtag tatatccact 33900 ctctcaaagc atccaggcgc cccctggctt cgggttctat gtaaactcct tcatgcgccg 33960 ctgccctgat aacatccacc accgcagaat aagccacacc cagccaacct acacattcgt 34020 tctgcgagtc acacacggga ggagcgggaa gagctggaag aaccatgttt ttttttttat 34080 tccaaaagat tatccaaaac ctcaaaatga agatctatta agtgaacgcg ctcccctccg 34140 gtggcgtggt caaactctac agccaaagaa cagataatgg catttgtaag atgttgcaca 34200 atggcttcca aaaggcaaac ggccctcacg tccaagtgga cgtaaaggct aaacccttca 34260 gggtgaatct cctctataaa cattccagca ccttcaacca tgcccaaata attctcatct 34320 cgccaccttc tcaatatatc tctaagcaaa tcccgaatat taagtccggc cattgtaaaa 34380 atctgctcca gagcgccctc caccttcagc ctcaagcagc gaatcatgat tgcaaaaatt 34440 caggttcctc acagacctgt ataagattca aaagcggaac attaacaaaa ataccgcgat 34500 cccgtaggtc ccttcgcagg gccagctgaa cataatcgtg caggtctgca cggaccagcg 34560 cggccacttc cccgccagga accatgacaa aagaacccac actgattatg acacgcatac 34620 tcggagctat gctaaccagc gtagccccga tgtaagcttg ttgcatgggc ggcgatataa 34680 aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg caaaaaagaa agcacatcgt 34740 agtcatgctc atgcagataa aggcaggtaa gctccggaac caccacagaa aaagacacca 34800 tttttctctc aaacatgtct gcgggtttct gcataaacac aaaataaaat aacaaaaaaa 34860 catttaagcc tgtcttacaa caggaaaaac aacccttata agcataagac ggactacggc 34920 catgccggcg tgaccgtaaa aaaactggtc accgtgatta aaaagcacca ccgacagctc 34980 ctcggtcatg tccggagtca taatgtaaga ctcggtaaac acatcaggtt gattcacatc 35040 ggtcagtgct aaaaagcgac cgaaatagcc cgggggaata catacccgca ggcgtagaga 35100 caacattaca gcccccatag gaggtataac aaaattaata ggagagaaaa acacataaac 35160 acctgaaaaa ccctcctgcc taggcaaaat agcaccctcc cgctccagaa caacatacag 35220 cgcttccaca gcggcagcca taacagtcag ccttaccagt aaaaaagaaa acctattaaa 35280 aaaacaccac tcgacacggc accagctcaa tcagtcacag tgtaaaaaag ggccaagtgc 35340 agagcgagta tatataggac taaaaaatga cgtaacggtt aaagtccaca aaaaacaccc 35400 agaaaaccgc acgcgaacct acgcccagaa acgaaagcca aaaaacccac aacttcctca 35460 aatcgtcact tccgttttcc cacgttacgt cacttcccat tttaagaaaa ctacaattcc 35520 caacacatac aagttactcc gccctaaaac ctacgtcacc cgccccgttc ccacgccccg 35580 cgccacgtca caaactccac cccctcatta tcatattggc ttcaatccaa aataaggtat 35640 attattgatg atg 35653 <210> 20 <211> 35228 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO295) <400> 20 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgcat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttaccgg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140 gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260 cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440 gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620 gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800 cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920 gccggtgggc ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca 4980 gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040 ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100 agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220 atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280 agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400 ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580 gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760 tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880 tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060 gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180 gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300 agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480 aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660 gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840 ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960 gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020 accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080 tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140 tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260 tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320 aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440 cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620 gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800 gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920 gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100 gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220 tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340 acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520 cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700 ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880 tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000 cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060 cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120 agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180 gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300 gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360 cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480 tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660 gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840 tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960 ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140 gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260 gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380 gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560 ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740 cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920 tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040 gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100 agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160 cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220 ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggtaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340 acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400 cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520 taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700 tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880 agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000 tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180 tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300 cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420 catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600 ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780 gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960 gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080 aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140 tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200 ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260 aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380 catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440 cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560 catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740 taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920 aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040 tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa 14100 taaaaaactc accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg 14160 cggcgcgcgg cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg 14220 gcgccagtgg cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg 14280 cctccgcggt acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca 14340 cccctattcg acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc 14400 ctgaactacc agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac 14460 agcccggggg aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc 14520 gacctgaaaa ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat 14580 aagtttaagg cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg 14640 aaatacgagt gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata 14700 gaccttatga acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt 14760 ctggaaagcg acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc 14820 gtcactggtc ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt 14880 ttgctgccag gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc 14940 cgcaagcggc aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt 15000 aacattcccg cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa 15060 cagggcgggg gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc 15120 aacgcggcag ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc 15180 gacacctttg ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct 15240 gccgcccccg ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc 15300 ctgacagagg acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc 15360 cagtaccgca gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca 15420 tggaccctgc tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg 15480 ccagacatga tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg 15540 gtggtgggcg ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc 15600 tactcccaac tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag 15660 aaccagattt tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct 15720 gctctcacag atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg 15780 accattactg acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc 15840 tcgccgcgcg tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc 15900 agcaataaca caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag 15960 cgctccgacc aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac 16020 aaacgcggcc gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag 16080 gcgcgcaact acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc 16140 gtggtgcgcg gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt 16200 cgccaccgcc gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc 16260 gcacgtcgca ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt 16320 gtcactgtgc cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt 16380 gctatgactc agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg 16440 cgcgtgcccg tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac 16500 tcgtactgtt gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa 16560 atcaaagaag agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa 16620 gagcaggatt acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat 16680 gatgaacttg acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag 16740 tggaaaggtc gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc 16800 ggtgagcgct ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac 16860 ctgcttgagc aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac 16920 atgctggcgt tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg 16980 cagcaggtgc tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct 17040 ggtgacttgg cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc 17100 ttggaaaaaa tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag 17160 caggtggcgc cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc 17220 accagtattg ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg 17280 gtggcggatg ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg 17340 caaacggacc cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag 17400 tacggcgccg ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc 17460 cccggctatc gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc 17520 accactggaa cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg 17580 cgcagggtgg ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc 17640 agcatcgttt aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc 17700 cgtttcccgg tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac 17760 ggcctgacgg gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc 17820 atgcgcggcg gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg 17880 cccggaattg catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg 17940 tggaaaaatc aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg 18000 tagaatggaa gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat 18060 gggaaactgg caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc 18120 gctgtggagc ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg 18180 gaacagcagc acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa 18240 ggtggtagat ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt 18300 gcaaaataag attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc 18360 cgtggagaca gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga 18420 aactctggtg acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct 18480 gcccaccacc cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt 18540 aacgctggac ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac 18600 cgccgttgtt gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg 18660 atcgttgcgg cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct 18720 gggggtgcaa tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg 18780 tcatgtatgc gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc 18840 aagatggcta ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac 18900 gcctcggagt acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc 18960 agcctgaata acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac 19020 cggtcccagc gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg 19080 tacaaggcgc ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg 19140 tactttgaca tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact 19200 gcctacaacg ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct 19260 actgctcttg aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag 19320 caagctgagc agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt 19380 acaaaggagg gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca 19440 tttcaacctg aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca 19500 gctgggagag tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa 19560 cccacaaatg aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa 19620 agtcaagtgg aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac 19680 ttgactccta aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat 19740 atttcttaca tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct 19800 atgcccaaca ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac 19860 aacagcacgg gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta 19920 gatttgcaag acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat 19980 agaaccaggt acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga 20040 attattgaaa atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt 20100 gtgattaata cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg 20160 gaaaaagatg ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc 20220 atggaaatca atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg 20280 tatttgcccg acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac 20340 acctacgact acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac 20400 cttggagcac gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc 20460 aatgctggcc tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac 20520 atccaggtgc ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac 20580 acctacgagt ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat 20640 gacctaaggg ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc 20700 ttccccatgg cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac 20760 gaccagtcct ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac 20820 gctaccaacg tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc 20880 ttcacgcgcc ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac 20940 acctactctg gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag 21000 aaggtggcca ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc 21060 cccaacgagt ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt 21120 aacatgacca aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag 21180 ggcttctata tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag 21240 cccatgagcc gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc 21300 ctacaccaac acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga 21360 caggcctacc ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt 21420 acccagaaaa agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt 21480 atgtccatgg gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac 21540 gcgctagaca tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg 21600 tttgaagtct ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg 21660 tacctgcgca cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa 21720 caacagctgc cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg 21780 gttgtgggcc atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac 21840 acaagctcgc ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga 21900 tggcctttgc ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt 21960 ctgaccagcg actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg 22020 ccattgcttc ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg 22080 ggcccaactc ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact 22140 ggccccaaac tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact 22200 ccatgctcaa cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca 22260 gcttcctgga gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca 22320 cttctttttg tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag 22380 gcaaatgctt ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg 22440 ccgtttaaaa atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt 22500 tgcgatactg gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg 22560 tgaagttttc actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg 22620 atatcttgaa gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt 22680 tgcagcactg gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg 22740 agatcagatc cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta 22800 gctgccttcc caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca 22860 tcaaaaggtg accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga 22920 tctgcttaaa agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc 22980 cggaaaactg attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg 23040 agatctgcac cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct 23100 ccttcagcgc gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat 23160 ttatcataat gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca 23220 gccacaacgc gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca 23280 ggtacgcctg caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca 23340 gctgcaaccc gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca 23400 cttggtcagg cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca 23460 tcagcgcgcg cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg 23520 ggttcatcac cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc 23580 gcataccacg cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt 23640 tgccatgctt gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt 23700 ctctttcttc ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag 23760 aagggcgctt ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc 23820 gcgggctggg tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact 23880 cgatacgccg cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg 23940 gggacgacac gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg 24000 tggtttcgcg ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga 24060 tcatggagtc agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg 24120 cctccaccga tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg 24180 aggaggaagt gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct 24240 cagtaccaac agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag 24300 tcgggcgggg ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga 24360 agcatctgca gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc 24420 ccctcgccat agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac 24480 cccccaaacg ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg 24540 tatttgccgt gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac 24600 ccctatcctg ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg 24660 ctgtcatacc tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac 24720 gcgacgagaa gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact 24780 ctggagtgtt ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca 24840 tcgaggtcac ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag 24900 tcatgagtga gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag 24960 aacaaacaga ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa 25020 cgcgcgagcc tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta 25080 ccgtggagct tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag 25140 aggaaacatt gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca 25200 acgtggagct ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc 25260 aaaacgtgct tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg 25320 tttacttatt tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg 25380 aggagtgcaa cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga 25440 cggccttcaa cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc 25500 tgcttaaaac cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact 25560 ttaggaactt tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta 25620 gcgactttgt gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc 25680 ttctgcagct agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg 25740 acggtctact ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt 25800 gcaattcgca gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct 25860 cgcctgacga aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg 25920 cttaccttcg caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag 25980 accaatcccg cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc 26040 ttggccaatt gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg 26100 gggtttactt ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc 26160 cctatcagca gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag 26220 ctgccgccgc cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg 26280 gacgaggagg aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag 26340 gtcgaagagg tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc 26400 cagaaatcgg caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca 26460 ctgcccgttc gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc 26520 aagcagccgc cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc 26580 gggcacaaga acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc 26640 cgccgctttc ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac 26700 cgtcatctct acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc 26760 cacacagaag caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc 26820 ggcggcagca gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg 26880 cgagcttaga aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca 26940 agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta 27000 tcacaaaagc gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa 27060 atactgcgcg ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa 27120 actacgtcat ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccatttatga 27180 gcaaggaaat tcccacgccc tacatgtgga gttaccagcc acaaatggga cttgcggctg 27240 gagctgccca agactactca acccgaataa actacatgag cgcgggaccc cacatgatat 27300 cccgggtcaa cggaatacgc gcccaccgaa accgaattct cctggaacag gcggctatta 27360 ccaccacacc tcgtaataac cttaatcccc gtagttggcc cgctgccctg gtgtaccagg 27420 aaagtcccgc tcccaccact gtggtacttc ccagagacgc ccaggccgaa gttcagatga 27480 ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg 27540 gtataactca cctgacaatc agagggcgag gtattcagct caacgacgag tcggtgagct 27600 cctcgcttgg tctccgtccg gacgggacat ttcagatcgg cggcgccggc cgctcttcat 27660 tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc ctctgagccg cgctctggag 27720 gcattggaac tctgcaattt attgaggagt ttgtgccatc ggtctacttt aaccccttct 27780 cgggacctcc cggccactat ccggatcaat ttattcctaa ctttgacgcg gtaaaggact 27840 cggcggacgg ctacgactga atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc 27900 tggtccactg tcgccgccac aagtgctttg cccgcgactc cggtgagttt tgctactttg 27960 aattgcccga ggatcatatc gagggcccgg cgcacggcgt ccggcttacc gcccagggag 28020 agcttgcccg tagcctgatt cgggagttta cccagcgccc cctgctagtt gagcgggaca 28080 ggggaccctg tgttctcact gtgatttgca actgtcctaa ccctggatta catcaagatc 28140 tttgttgcca tctctgtgct gagtataata aatacagaaa ttaaaatata ctggggctcc 28200 tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa gcaaaccaag gcgaacctta 28260 cctggtactt ttaacatctc tccctctgtg atttacaaca gtttcaaccc agacggagtg 28320 agtctacgag agaacctctc cgagctcagc tactccatca gaaaaaacac caccctcctt 28380 acctgccggg aacgtacgag tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt 28440 aaaccagact ttttccggac agacctcaat aactctgttt accagaacag gaggtgagct 28500 tagaaaaccc ttagggtatt aggccaaagg cgcagctact gtggggttta tgaacaattc 28560 aagcaactct acgggctatt ctaattcagg tttctctaga atcggggttg gggttattct 28620 ctgtcttgtg attctcttta ttcttatact aacgcttctc tgcctaaggc tcgccgcctg 28680 ctgtgtgcac atttgcattt attgtcagct ttttaaacgc tggggtcgcc acccaagatg 28740 attaggtaca taatcctagg tttactcacc cttgcgtcag cccacggtac cacccaaaag 28800 gtggatttta aggagccagc ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc 28860 actcttataa aatgcaccac agaacatgaa aagctgctta ttcgccacaa aaacaaaatt 28920 ggcaagtatg ctgtttatgc tatttggcag ccaggtgaca ctacagagta taatgttaca 28980 gttttccagg gtaaaagtca taaaactttt atgtatactt ttccatttta tgaaatgtgc 29040 gacattacca tgtacatgag caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa 29100 aacactggca ctttctgctg cactgctatg ctaattacag tgctcgcttt ggtctgtacc 29160 ctactctata ttaaatacaa aagcagacgc agctttattg aggaaaagaa aatgccttaa 29220 tttactaagt tacaaagcta atgtcaccac taactgcttt actcgctgct tgcaaaacaa 29280 attcaaaaag ttagcattat aattagaata ggatttaaac cccccggtca tttcctgctc 29340 aataccattc ccctgaacaa ttgactctat gtgggatatg ctccagcgct acaaccttga 29400 agtcaggctt cctggatgtc agcatctgac tttggccagc acctgtcccg cggatttgtt 29460 ccagtccaac tacagcgacc caccctaaca gagatgacca acacaaccaa cgcggccgcc 29520 gctaccggac ttacatctac cacaaataca ccccaagttt ctgcctttgt caataactgg 29580 gataacttgg gcatgtggtg gttctccata gcgcttatgt ttgtatgcct tattattatg 29640 tggctcatct gctgcctaaa gcgcaaacgc gcccgaccac ccatctatag tcccatcatt 29700 gtgctacacc caaacaatga tggaatccat agattggacg gactgaaaca catgttcttt 29760 tctcttacag tatgattaaa tgagacatga ttcctcgagt ttttatatta ctgacccttg 29820 ttgcgctttt ttgtgcgtgc tccacattgg ctgcggtttc tcacatcgaa gtagactgca 29880 ttccagcctt cacagtctat ttgctttacg gatttgtcac cctcacgctc atctgcagcc 29940 tcatcactgt ggtcatcgcc tttatccagt gcattgactg ggtctgtgtg cgctttgcat 30000 atctcagaca ccatccccag tacagggaca ggactatagc tgagcttctt agaattcttt 30060 aattatgaaa tttactgtga cttttctgct gattatttgc accctatctg cgttttgttc 30120 cccgacctcc aagcctcaaa gacatatatc atgcagattc actcgtatat ggaatattcc 30180 aagttgctac aatgaaaaaa gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt 30240 tatggtgttc tgcagtacca tcttagccct agctatatat ccctaccttg acattggctg 30300 gaacgcaata gatgccatga accacccaac tttccccgcg cccgctatgc ttccactgca 30360 acaagttgtt gccggcggct ttgtcccagc caatcagcct cgcccacctt ctcccacccc 30420 cactgaaatc agctacttta atctaacagg aggagatgac tgacacccta gatctagaaa 30480 tggacggaat tattacagag cagcgcctgc tagaaagacg cagggcagcg gccgagcaac 30540 agcgcatgaa tcaagagctc caagacatgg ttaacttgca ccagtgcaaa aggggtatct 30600 tttgtctggt aaagcaggcc aaagtcacct acgacagtaa taccaccgga caccgcctta 30660 gctacaagtt gccaaccaag cgtcagaaat tggtggtcat ggtgggagaa aagcccatta 30720 ccataactca gcactcggta gaaaccgaag gctgcattca ctcaccttgt caaggacctg 30780 aggatctctg cacccttatt aagaccctgt gcggtctcaa agatcttatt ccctttaact 30840 aataaaaaaa aataataaag catcacttac ttaaaatcag ttagcaaatt tctgtccagt 30900 ttattcagca gcacctcctt gccctcctcc cagctctggt attgcagctt cctcctggct 30960 gcaaactttc tccacaatct aaatggaatg tcagtttcct cctgttcctg tccatccgca 31020 cccactatct tcatgttgtt gcagatgaag cgcgcaagac cgtctgaaga taccttcaac 31080 cccgtgtatc catatgacac ggaaaccggt cctccaactg tgccttttct tactcctccc 31140 tttgtatccc ccaatgggtt tcaagagagt ccccctgggg tactctcttt gcgcctatcc 31200 gaacctctag ttacctccaa tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg 31260 gacgaggccg gcaaccttac ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa 31320 accaagtcaa acataaacct ggaaatatct gcacccctca cagttacctc agaagcccta 31380 actgtggctg ccgccgcacc tctaatggtc gcgggcaaca cactcaccat gcaatcacag 31440 gccccgctaa ccgtgcacga ctccaaactt agcattgcca cccaaggacc cctcacagtg 31500 tcagaaggaa agctagccct gcaaacatca ggccccctca ccaccaccga tagcagtacc 31560 cttactatca ctgcctcacc ccctctaact actgccactg gtagcttggg cattgacttg 31620 aaagagccca tttatacaca aaatggaaaa ctaggactaa agtacggggc tcctttgcat 31680 gtaacagacg acctaaacac tttgaccgta gcaactggtc caggtgtgac tattaataat 31740 acttccttgc aaactaaagt tactggagcc ttgggttttg attcacaagg caatatgcaa 31800 cttaatgtag caggaggact aaggattgat tctcaaaaca gacgccttat acttgatgtt 31860 agttatccgt ttgatgctca aaaccaacta aatctaagac taggacaggg ccctcttttt 31920 ataaactcag cccacaactt ggatattaac tacaacaaag gcctttactt gtttacagct 31980 tcaaacaatt ccaaaaagct tgaggttaac ctaagcactg ccaaggggtt gatgtttgac 32040 gctacagcca tagccattaa tgcaggagat gggcttgaat ttggttcacc taatgcacca 32100 aacacaaatc ccctcaaaac aaaaattggc catggcctag aatttgattc aaacaaggct 32160 atggttccta aactaggaac tggccttagt tttgacagca caggtgccat tacagtagga 32220 aacaaaaata atgataagct aactttgtgg accacaccag ctccatctcc taactgtaga 32280 ctaaatgcag agaaagatgc taaactcact ttggtcttaa caaaatgtgg cagtcaaata 32340 cttgctacag tttcagtttt ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt 32400 caaagtgctc atcttattat aagatttgac gaaaatggag tgctactaaa caattccttc 32460 ctggacccag aatattggaa ctttagaaat ggagatctta ctgaaggcac agcctataca 32520 aacgctgttg gatttatgcc taacctatca gcttatccaa aatctcacgg taaaactgcc 32580 aaaagtaaca ttgtcagtca agtttactta aacggagaca aaactaaacc tgtaacacta 32640 accattacac taaacggtac acaggaaaca ggagacacaa ctccaagtgc atactctatg 32700 tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc cacatcctct 32760 tacacttttt catacattgc ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt 32820 tatttttcaa ttgcagaaaa tttcgaatca tttttcattc agtagtatag ccccaccacc 32880 acatagctta tacagatcac cgtaccttaa tcaaacctac atgggggtag agtcataatc 32940 gtgcatcagg atagggcggt ggtgctgcag cagcgcgcga ataaactgct gccgccgccg 33000 ctccgtcctg caggaataca acatggcagt ggtctcctca gcgatgattc gcaccgcccg 33060 cagcataagg cgccttgtcc tccgggcaca gcagcgcacc ctgatctcac ttaaatcagc 33120 acagtaactg cagcacagca ccacaatatt gttcaaaatc ccacagtgca aggcgctgta 33180 tccaaagctc atggcgggga ccacagaacc cacgtggcca tcataccaca agcgcaggta 33240 gattaagtgg cgacccctca taaacacgct ggacataaac attacctctt ttggcatgtt 33300 gtaattcacc acctcccggt accatataaa cctctgatta aacatggcgc catccaccac 33360 catcctaaac cagctggcca aaacctgccc gccggctata cactgcaggg aaccgggact 33420 ggaacaatga cagtggagag cccaggactc gtaaccatgg atcatcatgc tcgtcatgat 33480 atcaatgttg gcacaacaca ggcacacgtg catacacttc ctcaggatta caagctcctc 33540 ccgcgttaga accatatccc agggaacaac ccattcctga atcagcgtaa atcccacact 33600 gcagggaaga cctcgcacgt aactcacgtt gtgcattgtc aaagtgttac attcgggcag 33660 cagcggatga tcctccagta tggtagcgcg ggtttctgtc tcaaaaggag gtagacgatc 33720 cctactgtac ggagtgcgcc gagacaaccg agatcgtgtt ggtcgtagtg tcatgccaaa 33780 tggaacgccg gacgtagtca tatttcctga agcaaaacca ggtgcgggcg tgacaaacag 33840 atctgcgtct ccggtctcgc cgcttagatc gctctgtgta gtagttgtag tatatccact 33900 ctctcaaagc atccaggcgc cccctggctt cgggttctat gtaaactcct tcatgcgccg 33960 ctgccctgat aacatccacc accgcagaat aagccacacc cagccaacct acacattcgt 34020 tctgcgagtc acacacggga ggagcgggaa gagctggaag aaccatgttt ttttttttat 34080 tccaaaagat tatccaaaac ctcaaaatga agatctatta agtgaacgcg ctcccctccg 34140 gtggcgtggt caaactctac agccaaagaa cagataatgg catttgtaag atgttgcaca 34200 atggcttcca aaaggcaaac ggccctcacg tccaagtgga cgtaaaggct aaacccttca 34260 gggtgaatct cctctataaa cattccagca ccttcaacca tgcccaaata attctcatct 34320 cgccaccttc tcaatatatc tctaagcaaa tcccgaatat taagtccggc cattgtaaaa 34380 atctgctcca gagcgccctc caccttcagc ctcaagcagc gaatcatgat tgcaaaaatt 34440 caggttcctc acagacctgt ataagattca aaagcggaac attaacaaaa ataccgcgat 34500 cccgtaggtc ccttcgcagg gccagctgaa cataatcgtg caggtctgca cggaccagcg 34560 cggccacttc cccgccagga accatgacaa aagaacccac actgattatg acacgcatac 34620 tcggagctat gctaaccagc gtagccccga tgtaagcttg ttgcatgggc ggcgatataa 34680 aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg caaaaaagaa agcacatcgt 34740 agtcatgctc atgcagataa aggcaggtaa gctccggaac caccacagaa aaagacacca 34800 tttttctctc aaacataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac 34860 accactcgac acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc 34920 gagtatatat aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa 34980 accgcacgcg aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg 35040 tcacttccgt tttcccacgt tacgtcactt cccattttaa gaaaactaca attcccaaca 35100 catacaagtt actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca 35160 cgtcacaaac tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat 35220 tgatgatg 35228 <210> 21 <211> 35911 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO244) <400> 21 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgaccgaaga aatggccgcc agtcttttgg accagctgat 600 cgaagaggta ctggctgata atcttccacc tcctagccat tttgaaccac ctacccttca 660 cgaactgcat gatttagacg tgacggcccc cgaagatccc aacgaggagg cggtttcgca 720 gatttttccc gactctgtaa tgttggcggt gcaggaaggg attgacttac tcacttttcc 780 gccggcgccc ggttctccgg agccgcctca cctttcccgg cagcccgagc agccggagca 840 gagagccttg ggtccggttt ctatgccaaa ccttgtaccg gaggtgatcg atcttaccgg 900 ccacgaggct ggctttccac ccagtgacga cgaggatgaa gagggtgagg agtttgtgtt 960 agattatgtg gagcaccccg ggcacggttg caggtcttgt cattatcacc ggaggaatac 1020 gggggaccca gatattatgt gttcgctttg ctatatgagg acctgtggca tgtttgtcta 1080 cagtaagtga aaattatggg cagtgggtga tagagtggtg ggtttggtgt ggtaattttt 1140 tttttaattt ttacagtttt gtggtttaaa gaattttgta ttgtgatttt tttaaaaggt 1200 cctgtgtctg aacctgagcc tgagcccgag ccagaaccgg agcctgcaag acctacccgc 1260 cgtcctaaaa tggcgcctgc tatcctgaga cgcccgacat cacctgtgtc tagagaatgc 1320 aatagtagta cggatagctg tgactccggt ccttctaaca cacctcctga gatacacccg 1380 gtggtcccgc tgtgccccat taaaccagtt gccgtgagag ttggtgggcg tcgccaggct 1440 gtggaatgta tcgaggactt gcttaacgag cctgggcaac ctttggactt gagctgtaaa 1500 cgccccaggc cataaggtgt aaacctgtga ttgcgtgtgt ggttaacgcc tttgtttgct 1560 gaatgagttg atgtaagttt aataaagggt gagataatgt ttaacttgca tggcgtgtta 1620 aatggggcgg ggcttaaagg gtatataatg cgccgtgggc taatcttggt tacatctgac 1680 ctcatggagg cttgggagtg tttggaagat ttttctgctg tgcgtaactt gctggaacag 1740 agctctaaca gtacctcttg gttttggagg tttctgtggg gctcatccca ggcaaagtta 1800 gtctgcagaa ttaaggagga ttacaagtgg gaatttgaag agcttttgaa atcctgtggt 1860 gagctgtttg attctttgaa tctgggtcac caggcgcttt tccaagagaa ggtcatcaag 1920 actttggatt tttccacacc ggggcgcgct gcggctgctg ttgctttttt gagttttata 1980 aaggataaat ggagcgaaga aacccatctg agcggggggt acctgctgga ttttctggcc 2040 atgcatctgt ggagagcggt tgtgagacac aagaatcgcc tgctactgtt gtcttccgtc 2100 cgcccggcga taataccgac ggaggagcag cagcagcagc aggaggaagc caggcggcgg 2160 cggcaggagc agagcccatg gaacccgaga gccggcctgg accctcggga atgaatgttg 2220 tacaggtggc tgaactgtat ccagaactga gacgcatttt gacaattaca gaggatgggc 2280 aggggctaaa gggggtaaag agggagcggg gggcttgtga ggctacagag gaggctagga 2340 atctagcttt tagcttaatg accagacacc gtcctgagtg tattactttt caacagatca 2400 aggataattg cgctaatgag cttgatctgc tggcgcagaa gtattccata gagcagctga 2460 ccacttactg gctgcagcca ggggatgatt ttgaggaggc tattagggta tatgcaaagg 2520 tggcacttag gccagattgc aagtacaaga tcagcaaact tgtaaatatc aggaattgtt 2580 gctacatttc tgggaacggg gccgaggtgg agatagatac ggaggatagg gtggccttta 2640 gatgtagcat gataaatatg tggccggggg tgcttggcat ggacggggtg gttattatga 2700 atgtaaggtt tactggcccc aattttagcg gtacggtttt cctggccaat accaacctta 2760 tcctacacgg tgtaagcttc tatgggttta acaatacctg tgtggaagcc tggaccgatg 2820 taagggttcg gggctgtgcc ttttactgct gctggaaggg ggtggtgtgt cgccccaaaa 2880 gcagggcttc aattaagaaa tgcctctttg aaaggtgtac cttgggtatc ctgtctgagg 2940 gtaactccag ggtgcgccac aatgtggcct ccgactgtgg ttgcttcatg ctagtgaaaa 3000 gcgtggctgt gattaagcat aacatggtat gtggcaactg cgaggacagg gcctctcaga 3060 tgctgacctg ctcggacggc aactgtcacc tgctgaagac cattcacgta gccagccact 3120 ctcgcaaggc ctggccagtg tttgagcata acatactgac ccgctgttcc ttgcatttgg 3180 gtaacaggag gggggtgttc ctaccttacc aatgcaattt gagtcacact aagatattgc 3240 ttgagcccga gagcatgtcc aaggtgaacc tgaacggggt gtttgacatg accatgaaga 3300 tctggaaggt gctgaggtac gatgagaccc gcaccaggtg cagaccctgc gagtgtggcg 3360 gtaaacatat taggaaccag cctgtgatgc tggatgtgac cgaggagctg aggcccgatc 3420 acttggtgct ggcctgcacc cgcgctgagt ttggctctag cgatgaagat acagattgag 3480 gtactgaaat gtgtgggcgt ggcttaaggg tgggaaagaa tatataaggt gggggtctta 3540 tgtagttttg tatctgtttt gcagcagccg ccgccgccat gagcaccaac tcgtttgatg 3600 gaagcattgt gagctcatat ttgacaacgc gcatgccccc atgggccggg gtgcgtcaga 3660 atgtgatggg ctccagcatt gatggtcgcc ccgtcctgcc cgcaaactct actaccttga 3720 cctacgagac cgtgtctgga acgccgttgg agactgcagc ctccgccgcc gcttcagccg 3780 ctgcagccac cgcccgcggg attgtgactg actttgcttt cctgagcccg cttgcaagca 3840 gtgcagcttc ccgttcatcc gcccgcgatg acaagttgac ggctcttttg gcacaattgg 3900 attctttgac ccgggaactt aatgtcgttt ctcagcagct gttggatctg cgccagcagg 3960 tttctgccct gaaggcttcc tcccctccca atgcggttta aaacataaat aaaaaaccag 4020 actctgtttg gatttggatc aagcataagt gtcttgctgt ctttatttag gggttttgcg 4080 cgcgcggtag gcccgggacc agcggtctcg gtcgttgagg gtcctgtgta ttttttccag 4140 gacgtggtaa aggtgactct ggatgttcag atacatgggc ataagcccgt ctctggggtg 4200 gaggtagcac cactgcagag cttcatgctg cggggtggtg ttgtagatga tccagtcgta 4260 gcaggagcgc tgggcgtggt gcctaaaaat gtctttcagt agcaagctga ttgccagggg 4320 caggcccttg gtgtaagtgt ttacaaagcg gttaagctgg gatgggtgca tacgtgggga 4380 tatgagatgc atcttggact gtatttttag gttggctatg ttcccagcca tatccctccg 4440 gggattcatg ttgtgcagaa ccaccagcac agtgtatccg gtgcacttgg gaaatttgtc 4500 atgtagctta gaaggaaatg cgtggaagaa cttggagacg cccttgtgac ctccaagatt 4560 ttccatgcat tcgtccataa tgatggcaat gggcccacgg gcggcggcct gggcgaagat 4620 atttctggga tcactaacgt catagttgtg ttccaggatg agatcgtcat aggccatttt 4680 tacaaagcgc gggcggaggg tgccagactg cggtataatg gttccatccg gcccaggggc 4740 gtagttaccc tcacagattt gcatttccca cgctttgagt tcagatgggg ggatcatgtc 4800 tacctgcggg gcgatgaaga aaacggtttc cggggtaggg gagatcagct gggaagaaag 4860 caggttcctg agcagctgcg acttaccgca gccggtgggc ccgtaaatca cacctattac 4920 cgggtgcaac tggtagttaa gagagctgca gctgccgtca tccctgagca ggggggccac 4980 ttcgttaagc atgtccctga ctcgcatgtt ttccctgacc aaatccgcca gaaggcgctc 5040 gccgcccagc gatagcagtt cttgcaagga agcaaagttt ttcaacggtt tgagaccgtc 5100 cgccgtaggc atgcttttga gcgtttgacc aagcagttcc aggcggtccc acagctcggt 5160 cacctgctct acggcatctc gatccagcat atctcctcgt ttcgcgggtt ggggcggctt 5220 tcgctgtacg gcagtagtcg gtgctcgtcc agacgggcca gggtcatgtc tttccacggg 5280 cgcagggtcc tcgtcagcgt agtctgggtc acggtgaagg ggtgcgctcc gggctgcgcg 5340 ctggccaggg tgcgcttgag gctggtcctg ctggtgctga agcgctgccg gtcttcgccc 5400 tgcgcgtcgg ccaggtagca tttgaccatg gtgtcatagt ccagcccctc cgcggcgtgg 5460 cccttggcgc gcagcttgcc cttggaggag gcgccgcacg aggggcagtg cagacttttg 5520 agggcgtaga gcttgggcgc gagaaatacc gattccgggg agtaggcatc cgcgccgcag 5580 gccccgcaga cggtctcgca ttccacgagc caggtgagct ctggccgttc ggggtcaaaa 5640 accaggtttc ccccatgctt tttgatgcgt ttcttacctc tggtttccat gagccggtgt 5700 ccacgctcgg tgacgaaaag gctgtccgtg tccccgtata cagacttgag aggcctgtcc 5760 tcgagcggtg ttccgcggtc ctcctcgtat agaaactcgg accactctga gacaaaggct 5820 cgcgtccagg ccagcacgaa ggaggctaag tgggaggggt agcggtcgtt gtccactagg 5880 gggtccactc gctccagggt gtgaagacac atgtcgccct cttcggcatc aaggaaggtg 5940 attggtttgt aggtgtaggc cacgtgaccg ggtgttcctg aaggggggct ataaaagggg 6000 gtgggggcgc gttcgtcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg 6060 ggtgagtact ccctctgaaa agcgggcatg acttctgcgc taagattgtc agtttccaaa 6120 aacgaggagg atttgatatt cacctggccc gcggtgatgc ctttgagggt ggccgcatcc 6180 atctggtcag aaaagacaat ctttttgttg tcaagcttgg tggcaaacga cccgtagagg 6240 gcgttggaca gcaacttggc gatggagcgc agggtttggt ttttgtcgcg atcggcgcgc 6300 tccttggccg cgatgtttag ctgcacgtat tcgcgcgcaa cgcaccgcca ttcgggaaag 6360 acggtggtgc gctcgtcggg caccaggtgc acgcgccaac cgcggttgtg cagggtgaca 6420 aggtcaacgc tggtggctac ctctccgcgt aggcgctcgt tggtccagca gaggcggccg 6480 cccttgcgcg agcagaatgg cggtaggggg tctagctgcg tctcgtccgg ggggtctgcg 6540 tccacggtaa agaccccggg cagcaggcgc gcgtcgaagt agtctatctt gcatccttgc 6600 aagtctagcg cctgctgcca tgcgcgggcg gcaagcgcgc gctcgtatgg gttgagtggg 6660 ggaccccatg gcatggggtg ggtgagcgcg gaggcgtaca tgccgcaaat gtcgtaaacg 6720 tagaggggct ctctgagtat tccaagatat gtagggtagc atcttccacc gcggatgctg 6780 gcgcgcacgt aatcgtatag ttcgtgcgag ggagcgagga ggtcgggacc gaggttgcta 6840 cgggcgggct gctctgctcg gaagactatc tgcctgaaga tggcatgtga gttggatgat 6900 atggttggac gctggaagac gttgaagctg gcgtctgtga gacctaccgc gtcacgcacg 6960 aaggaggcgt aggagtcgcg cagcttgttg accagctcgg cggtgacctg cacgtctagg 7020 gcgcagtagt ccagggtttc cttgatgatg tcatacttat cctgtccctt ttttttccac 7080 agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt actcttggat cggaaacccg 7140 tcggcctccg aacggtaaga gcctagcatg tagaactggt tgacggcctg gtaggcgcag 7200 catccctttt ctacgggtag cgcgtatgcc tgcgcggcct tccggagcga ggtgtgggtg 7260 agcgcaaagg tgtccctgac catgactttg aggtactggt atttgaagtc agtgtcgtcg 7320 catccgccct gctcccagag caaaaagtcc gtgcgctttt tggaacgcgg atttggcagg 7380 gcgaaggtga catcgttgaa gagtatcttt cccgcgcgag gcataaagtt gcgtgtgatg 7440 cggaagggtc ccggcacctc ggaacggttg ttaattacct gggcggcgag cacgatctcg 7500 tcaaagccgt tgatgttgtg gcccacaatg taaagttcca agaagcgcgg gatgcccttg 7560 atggaaggca attttttaag ttcctcgtag gtgagctctt caggggagct gagcccgtgc 7620 tctgaaaggg cccagtctgc aagatgaggg ttggaagcga cgaatgagct ccacaggtca 7680 cgggccatta gcatttgcag gtggtcgcga aaggtcctaa actggcgacc tatggccatt 7740 ttttctgggg tgatgcagta gaaggtaagc gggtcttgtt cccagcggtc ccatccaagg 7800 ttcgcggcta ggtctcgcgc ggcagtcact agaggctcat ctccgccgaa cttcatgacc 7860 agcatgaagg gcacgagctg cttcccaaag gcccccatcc aagtataggt ctctacatcg 7920 taggtgacaa agagacgctc ggtgcgagga tgcgagccga tcgggaagaa ctggatctcc 7980 cgccaccaat tggaggagtg gctattgatg tggtgaaagt agaagtccct gcgacgggcc 8040 gaacactcgt gctggctttt gtaaaaacgt gcgcagtact ggcagcggtg cacgggctgt 8100 acatcctgca cgaggttgac ctgacgaccg cgcacaagga agcagagtgg gaatttgagc 8160 ccctcgcctg gcgggtttgg ctggtggtct tctacttcgg ctgcttgtcc ttgaccgtct 8220 ggctgctcga ggggagttac ggtggatcgg accaccacgc cgcgcgagcc caaagtccag 8280 atgtccgcgc gcggcggtcg gagcttgatg acaacatcgc gcagatggga gctgtccatg 8340 gtctggagct cccgcggcgt caggtcaggc gggagctcct gcaggtttac ctcgcataga 8400 cgggtcaggg cgcgggctag atccaggtga tacctaattt ccaggggctg gttggtggcg 8460 gcgtcgatgg cttgcaagag gccgcatccc cgcggcgcga ctacggtacc gcgcggcggg 8520 cggtgggccg cgggggtgtc cttggatgat gcatctaaaa gcggtgacgc gggcgagccc 8580 ccggaggtag ggggggctcc ggacccgccg ggagaggggg caggggcacg tcggcgccgc 8640 gcgcgggcag gagctggtgc tgcgcgcgta ggttgctggc gaacgcgacg acgcggcggt 8700 tgatctcctg aatctggcgc ctctgcgtga agacgacggg cccggtgagc ttgagcctga 8760 aagagagttc gacagaatca atttcggtgt cgttgacggc ggcctggcgc aaaatctcct 8820 gcacgtctcc tgagttgtct tgataggcga tctcggccat gaactgctcg atctcttcct 8880 cctggagatc tccgcgtccg gctcgctcca cggtggcggc gaggtcgttg gaaatgcggg 8940 ccatgagctg cgagaaggcg ttgaggcctc cctcgttcca gacgcggctg tagaccacgc 9000 ccccttcggc atcgcgggcg cgcatgacca cctgcgcgag attgagctcc acgtgccggg 9060 cgaagacggc gtagtttcgc aggcgctgaa agaggtagtt gagggtggtg gcggtgtgtt 9120 ctgccacgaa gaagtacata acccagcgtc gcaacgtgga ttcgttgata tcccccaagg 9180 cctcaaggcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc 9240 gcgccgacac ggttaactcc tcctccagaa gacggatgag ctcggcgaca gtgtcgcgca 9300 cctcgcgctc aaaggctaca ggggcctctt cttcttcttc aatctcctct tccataaggg 9360 cctccccttc ttcttcttct ggcggcggtg ggggaggggg gacacggcgg cgacgacggc 9420 gcaccgggag gcggtcgaca aagcgctcga tcatctcccc gcggcgacgg cgcatggtct 9480 cggtgacggc gcggccgttc tcgcgggggc gcagttggaa gacgccgccc gtcatgtccc 9540 ggttatgggt tggcgggggg ctgccatgcg gcagggatac ggcgctaacg atgcatctca 9600 acaattgttg tgtaggtact ccgccgccga gggacctgag cgagtccgca tcgaccggat 9660 cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc gcaaggtagg ctgagcaccg 9720 tggcgggcgg cagcgggcgg cggtcggggt tgtttctggc ggaggtgctg ctgatgatgt 9780 aattaaagta ggcggtcttg agacggcgga tggtcgacag aagcaccatg tccttgggtc 9840 cggcctgctg aatgcgcagg cggtcggcca tgccccaggc ttcgttttga catcggcgca 9900 ggtctttgta gtagtcttgc atgagccttt ctaccggcac ttcttcttct ccttcctctt 9960 gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga gtttggccgt aggtggcgcc 10020 ctcttcctcc catgcgtgtg accccgaagc ccctcatcgg ctgaagcagg gctaggtcgg 10080 cgacaacgcg ctcggctaat atggcctgct gcacctgcgt gagggtagac tggaagtcat 10140 ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt gtaagtgcag ttggccataa 10200 cggaccagtt aacggtctgg tgacccggct gcgagagctc ggtgtacctg agacgcgagt 10260 aagccctcga gtcaaatacg tagtcgttgc aagtccgcac caggtactgg tatcccacca 10320 aaaagtgcgg cggcggctgg cggtagaggg gccagcgtag ggtggccggg gctccggggg 10380 cgagatcttc caacataagg cgatgatatc cgtagatgta cctggacatc caggtgatgc 10440 cggcggcggt ggtggaggcg cgcggaaagt cgcggacgcg gttccagatg ttgcgcagcg 10500 gcaaaaagtg ctccatggtc gggacgctct ggccggtcag gcgcgcgcaa tcgttgacgc 10560 tctagaccgt gcaaaaggag agcctgtaag cgggcactct tccgtggtct ggtggataaa 10620 ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc cgtatccggc cgtccgccgt 10680 gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga caacggggga 10740 gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc gctagctttt ttggccactg 10800 gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc tcgctccctg 10860 tagccggagg gttattttcc aagggttgag tcgcgggacc cccggttcga gtctcggacc 10920 ggccggactg cggcgaacgg gggtttgcct ccccgtcatg caagaccccg cttgcaaatt 10980 cctccggaaa cagggacgag cccctttttt gcttttccca gatgcatccg gtgctgcggc 11040 agatgcgccc ccctcctcag cagcggcaag agcaagagca gcggcagaca tgcagggcac 11100 cctcccctcc tcctaccgcg tcaggagggg cgacatccgc ggttgacgcg gcagcagatg 11160 gtgattacga acccccgcgg cgccgggccc ggcactacct ggacttggag gagggcgagg 11220 gcctggcgcg gctaggagcg ccctctcctg agcggtaccc aagggtgcag ctgaagcgtg 11280 atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg cgaccgcgag ggagaggagc 11340 ccgaggagat gcgggatcga aagttccacg cagggcgcga gctgcggcat ggcctgaatc 11400 gcgagcggtt gctgcgcgag gaggactttg agcccgacgc gcgaaccggg attagtcccg 11460 cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata cgagcagacg gtgaaccagg 11520 agattaactt tcaaaaaagc tttaacaacc acgtgcgtac gcttgtggcg cgcgaggagg 11580 tggctatagg actgatgcat ctgtgggact ttgtaagcgc gctggagcaa aacccaaata 11640 gcaagccgct catggcgcag ctgttcctta tagtgcagca cagcagggac aacgaggcat 11700 tcagggatgc gctgctaaac atagtagagc ccgagggccg ctggctgctc gatttgataa 11760 acatcctgca gagcatagtg gtgcaggagc gcagcttgag cctggctgac aaggtggccg 11820 ccatcaacta ttccatgctt agcctgggca agttttacgc ccgcaagata taccataccc 11880 cttacgttcc catagacaag gaggtaaaga tcgaggggtt ctacatgcgc atggcgctga 11940 aggtgcttac cttgagcgac gacctgggcg tttatcgcaa cgagcgcatc cacaaggccg 12000 tgagcgtgag ccggcggcgc gagctcagcg accgcgagct gatgcacagc ctgcaaaggg 12060 ccctggctgg cacgggcagc ggcgatagag aggccgagtc ctactttgac gcgggcgctg 12120 acctgcgctg ggccccaagc cgacgcgccc tggaggcagc tggggccgga cctgggctgg 12180 cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga ggaatatgac gaggacgatg 12240 agtacgagcc agaggacggc gagtactaag cggtgatgtt tctgatcaga tgatgcaaga 12300 cgcaacggac ccggcggtgc gggcggcgct gcagagccag ccgtccggcc ttaactccac 12360 ggacgactgg cgccaggtca tggaccgcat catgtcgctg actgcgcgca atcctgacgc 12420 gttccggcag cagccgcagg ccaaccggct ctccgcaatt ctggaagcgg tggtcccggc 12480 gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta aacgcgctgg ccgaaaacag 12540 ggccatccgg cccgacgagg ccggcctggt ctacgacgcg ctgcttcagc gcgtggctcg 12600 ttacaacagc ggcaacgtgc agaccaacct ggaccggctg gtgggggatg tgcgcgaggc 12660 cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg ggctccatgg ttgcactaaa 12720 cgccttcctg agtacacagc ccgccaacgt gccgcgggga caggaggact acaccaactt 12780 tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa agtgaggtgt accagtctgg 12840 gccagactat tttttccaga ccagtagaca aggcctgcag accgtaaacc tgagccaggc 12900 tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc acaggcgacc gcgcgaccgt 12960 gtctagcttg ctgacgccca actcgcgcct gttgctgctg ctaatagcgc ccttcacgga 13020 cagtggcagc gtgtcccggg acacatacct aggtcacttg ctgacactgt accgcgaggc 13080 cataggtcag gcgcatgtgg acgagcatac tttccaggag attacaagtg tcagccgcgc 13140 gctggggcag gaggacacgg gcagcctgga ggcaacccta aactacctgc tgaccaaccg 13200 gcggcagaag atcccctcgt tgcacagttt aaacagcgag gaggagcgca ttttgcgcta 13260 cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg gtaacgccca gcgtggcgct 13320 ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc tcaaaccggc cgtttatcaa 13380 ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac cccgagtatt tcaccaatgc 13440 catcttgaac ccgcactggc taccgccccc tggtttctac accgggggat tcgaggtgcc 13500 cgagggtaac gatggattcc tctgggacga catagacgac agcgtgtttt ccccgcaacc 13560 gcagaccctg ctagagttgc aacagcgcga gcaggcagag gcggcgctgc gaaaggaaag 13620 cttccgcagg ccaagcagct tgtccgatct aggcgctgcg gccccgcggt cagatgctag 13680 tagcccattt ccaagcttga tagggtctct taccagcact cgcaccaccc gcccgcgcct 13740 gctgggcgag gaggagtacc taaacaactc gctgctgcag ccgcagcgcg aaaaaaacct 13800 gcctccggca tttcccaaca acgggataga gagcctagtg gacaagatga gtagatggaa 13860 gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc ccgcccaccc gtcgtcaaag 13920 gcacgaccgt cagcggggtc tggtgtggga ggacgatgac tcggcagacg acagcagcgt 13980 cctggatttg ggagggagtg gcaacccgtt tgcgcacctt cgccccaggc tggggagaat 14040 gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc accaaggcca tggcaccgag 14100 cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg cgatgtatga ggaaggtcct 14160 cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg cggcggcgct gggttctccc 14220 ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt acctgcggcc taccgggggg 14280 agaaacagca tccgttactc tgagttggca cccctattcg acaccacccg tgtgtacctg 14340 gtggacaaca agtcaacgga tgtggcatcc ctgaactacc agaacgacca cagcaacttt 14400 ctgaccacgg tcattcaaaa caatgactac agcccggggg aggcaagcac acagaccatc 14460 aatcttgacg accggtcgca ctggggcggc gacctgaaaa ccatcctgca taccaacatg 14520 ccaaatgtga acgagttcat gtttaccaat aagtttaagg cgcgggtgat ggtgtcgcgc 14580 ttgcctacta aggacaatca ggtggagctg aaatacgagt gggtggagtt cacgctgccc 14640 gagggcaact actccgagac catgaccata gaccttatga acaacgcgat cgtggagcac 14700 tacttgaaag tgggcagaca gaacggggtt ctggaaagcg acatcggggt aaagtttgac 14760 acccgcaact tcagactggg gtttgacccc gtcactggtc ttgtcatgcc tggggtatat 14820 acaaacgaag ccttccatcc agacatcatt ttgctgccag gatgcggggt ggacttcacc 14880 cacagccgcc tgagcaactt gttgggcatc cgcaagcggc aacccttcca ggagggcttt 14940 aggatcacct acgatgatct ggagggtggt aacattcccg cactgttgga tgtggacgcc 15000 taccaggcga gcttgaaaga tgacaccgaa cagggcgggg gtggcgcagg cggcagcaac 15060 agcagtggca gcggcgcgga agagaactcc aacgcggcag ccgcggcaat gcagccggtg 15120 gaggacatga acgatcatgc cattcgcggc gacacctttg ccacacgggc tgaggagaag 15180 cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg ctgcgcaacc cgaggtcgag 15240 aagcctcaga agaaaccggt gatcaaaccc ctgacagagg acagcaagaa acgcagttac 15300 aacctaataa gcaatgacag caccttcacc cagtaccgca gctggtacct tgcatacaac 15360 tacggcgacc ctcagaccgg aatccgctca tggaccctgc tttgcactcc tgacgtaacc 15420 tgcggctcgg agcaggtcta ctggtcgttg ccagacatga tgcaagaccc cgtgaccttc 15480 cgctccacgc gccagatcag caactttccg gtggtgggcg ccgagctgtt gcccgtgcac 15540 tccaagagct tctacaacga ccaggccgtc tactcccaac tcatccgcca gtttacctct 15600 ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc gccagccccc 15660 accatcacca ccgtcagtga aaacgttcct gctctcacag atcacgggac gctaccgctg 15720 cgcaacagca tcggaggagt ccagcgagtg accattactg acgccagacg ccgcacctgc 15780 ccctacgttt acaaggccct gggcatagtc tcgccgcgcg tcctatcgag ccgcactttt 15840 tgagcaagca tgtccatcct tatatcgccc agcaataaca caggctgggg cctgcgcttc 15900 ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc aacacccagt gcgcgtgcgc 15960 gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc gcactgggcg caccaccgtc 16020 gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact acacgcccac gccgccacca 16080 gtgtccacag tggacgcggc cattcagacc gtggtgcgcg gagcccggcg ctatgctaaa 16140 atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc gccgacccgg cactgccgcc 16200 caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca ccggccgacg ggcggccatg 16260 cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc cccccaggtc caggcgacga 16320 gcggccgccg cagcagccgc ggccattagt gctatgactc agggtcgcag gggcaacgtg 16380 tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg tgcgcacccg ccccccgcgc 16440 aactagattg caagaaaaaa ctacttagac tcgtactgtt gtatgtatcc agcggcggcg 16500 gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag agatgctcca ggtcatcgcg 16560 ccggagatct atggcccccc gaagaaggaa gagcaggatt acaagccccg aaagctaaag 16620 cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg acgacgaggt ggaactgctg 16680 cacgctaccg cgcccaggcg acgggtacag tggaaaggtc gacgcgtaaa acgtgttttg 16740 cgacccggca ccaccgtagt ctttacgccc ggtgagcgct ccacccgcac ctacaagcgc 16800 gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc aggccaacga gcgcctcggg 16860 gagtttgcct acggaaagcg gcataaggac atgctggcgt tgccgctgga cgagggcaac 16920 ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc tgcccgcgct tgcaccgtcc 16980 gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg cacccaccgt gcagctgatg 17040 gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa tgaccgtgga acctgggctg 17100 gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc cgggactggg cgtgcagacc 17160 gtggacgttc agatacccac taccagtagc accagtattg ccaccgccac agagggcatg 17220 gagacacaaa cgtccccggt tgcctcagcg gtggcggatg ccgcggtgca ggcggtcgct 17280 gcggccgcgt ccaagacctc tacggaggtg caaacggacc cgtggatgtt tcgcgtttca 17340 gccccccggc gcccgcgcgg ttcgaggaag tacggcgccg ccagcgcgct actgcccgaa 17400 tatgccctac atccttccat tgcgcctacc cccggctatc gtggctacac ctaccgcccc 17460 agaagacgag caactacccg acgccgaacc accactggaa cccgccgccg ccgtcgccgt 17520 cgccagcccg tgctggcccc gatttccgtg cgcagggtgg ctcgcgaagg aggcaggacc 17580 ctggtgctgc caacagcgcg ctaccacccc agcatcgttt aaaagccggt ctttgtggtt 17640 cttgcagata tggccctcac ctgccgcctc cgtttcccgg tgccgggatt ccgaggaaga 17700 atgcaccgta ggaggggcat ggccggccac ggcctgacgg gcggcatgcg tcgtgcgcac 17760 caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg gtatcctgcc cctccttatt 17820 ccactgatcg ccgcggcgat tggcgccgtg cccggaattg catccgtggc cttgcaggcg 17880 cagagacact gattaaaaac aagttgcatg tggaaaaatc aaaataaaaa gtctggactc 17940 tcacgctcgc ttggtcctgt aactattttg tagaatggaa gacatcaact ttgcgtctct 18000 ggccccgcga cacggctcgc gcccgttcat gggaaactgg caagatatcg gcaccagcaa 18060 tatgagcggt ggcgccttca gctggggctc gctgtggagc ggcattaaaa atttcggttc 18120 caccgttaag aactatggca gcaaggcctg gaacagcagc acaggccaga tgctgaggga 18180 taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat ggcctggcct ctggcattag 18240 cggggtggtg gacctggcca accaggcagt gcaaaataag attaacagta agcttgatcc 18300 ccgccctccc gtagaggagc ctccaccggc cgtggagaca gtgtctccag aggggcgtgg 18360 cgaaaagcgt ccgcgccccg acagggaaga aactctggtg acgcaaatag acgagcctcc 18420 ctcgtacgag gaggcactaa agcaaggcct gcccaccacc cgtcccatcg cgcccatggc 18480 taccggagtg ctgggccagc acacacccgt aacgctggac ctgcctcccc ccgccgacac 18540 ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt gtaacccgtc ctagccgcgc 18600 gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg cccgtagcca gtggcaactg 18660 gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa tccctgaagc gccgacgatg 18720 cttctgaata gctaacgtgt cgtatgtgtg tcatgtatgc gtccatgtcg ccgccagagg 18780 agctgctgag ccgccgcgcg cccgctttcc aagatggcta ccccttcgat gatgccgcag 18840 tggtcttaca tgcacatctc gggccaggac gcctcggagt acctgagccc cgggctggtg 18900 cagtttgccc gcgccaccga gacgtacttc agcctgaata acaagtttag aaaccccacg 18960 gtggcgccta cgcacgacgt gaccacagac cggtcccagc gtttgacgct gcggttcatc 19020 cctgtggacc gtgaggatac tgcgtactcg tacaaggcgc ggttcaccct agctgtgggt 19080 gataaccgtg tgctggacat ggcttccacg tactttgaca tccgcggcgt gctggacagg 19140 ggccctactt ttaagcccta ctctggcact gcctacaacg ccctggctcc caagggtgcc 19200 ccaaatcctt gcgaatggga tgaagctgct actgctcttg aaataaacct agaagaagag 19260 gacgatgaca acgaagacga agtagacgag caagctgagc agcaaaaaac tcacgtattt 19320 gggcaggcgc cttattctgg tataaatatt acaaaggagg gtattcaaat aggtgtcgaa 19380 ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg aacctcaaat aggagaatct 19440 cagtggtacg aaactgaaat taatcatgca gctgggagag tccttaaaaa gactacccca 19500 atgaaaccat gttacggttc atatgcaaaa cccacaaatg aaaatggagg gcaaggcatt 19560 cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg aaatgcaatt tttctcaact 19620 actgaggcga ccgcaggcaa tggtgataac ttgactccta aagtggtatt gtacagtgaa 19680 gatgtagata tagaaacccc agacactcat atttcttaca tgcccactat taaggaaggt 19740 aactcacgag aactaatggg ccaacaatct atgcccaaca ggcctaatta cattgctttt 19800 agggacaatt ttattggtct aatgtattac aacagcacgg gtaatatggg tgttctggcg 19860 ggccaagcat cgcagttgaa tgctgttgta gatttgcaag acagaaacac agagctttca 19920 taccagcttt tgcttgattc cattggtgat agaaccaggt acttttctat gtggaatcag 19980 gctgttgaca gctatgatcc agatgttaga attattgaaa atcatggaac tgaagatgaa 20040 cttccaaatt actgctttcc actgggaggt gtgattaata cagagactct taccaaggta 20100 aaacctaaaa caggtcagga aaatggatgg gaaaaagatg ctacagaatt ttcagataaa 20160 aatgaaataa gagttggaaa taattttgcc atggaaatca atctaaatgc caacctgtgg 20220 agaaatttcc tgtactccaa catagcgctg tatttgcccg acaagctaaa gtacagtcct 20280 tccaacgtaa aaatttctga taacccaaac acctacgact acatgaacaa gcgagtggtg 20340 gctcccgggt tagtggactg ctacattaac cttggagcac gctggtccct tgactatatg 20400 gacaacgtca acccatttaa ccaccaccgc aatgctggcc tgcgctaccg ctcaatgttg 20460 ctgggcaatg gtcgctatgt gcccttccac atccaggtgc ctcagaagtt ctttgccatt 20520 aaaaacctcc ttctcctgcc gggctcatac acctacgagt ggaacttcag gaaggatgtt 20580 aacatggttc tgcagagctc cctaggaaat gacctaaggg ttgacggagc cagcattaag 20640 tttgatagca tttgccttta cgccaccttc ttccccatgg cccacaacac cgcctccacg 20700 cttgaggcca tgcttagaaa cgacaccaac gaccagtcct ttaacgacta tctctccgcc 20760 gccaacatgc tctaccctat acccgccaac gctaccaacg tgcccatatc catcccctcc 20820 cgcaactggg cggctttccg cggctgggcc ttcacgcgcc ttaagactaa ggaaacccca 20880 tcactgggct cgggctacga cccttattac acctactctg gctctatacc ctacctagat 20940 ggaacctttt acctcaacca cacctttaag aaggtggcca ttacctttga ctcttctgtc 21000 agctggcctg gcaatgaccg cctgcttacc cccaacgagt ttgaaattaa gcgctcagtt 21060 gacggggagg gttacaacgt tgcccagtgt aacatgacca aagactggtt cctggtacaa 21120 atgctagcta actacaacat tggctaccag ggcttctata tcccagagag ctacaaggac 21180 cgcatgtact ccttctttag aaacttccag cccatgagcc gtcaggtggt ggatgatact 21240 aaatacaagg actaccaaca ggtgggcatc ctacaccaac acaacaactc tggatttgtt 21300 ggctaccttg cccccaccat gcgcgaagga caggcctacc ctgctaactt cccctatccg 21360 cttataggca agaccgcagt tgacagcatt acccagaaaa agtttctttg cgatcgcacc 21420 ctttggcgca tcccattctc cagtaacttt atgtccatgg gcgcactcac agacctgggc 21480 caaaaccttc tctacgccaa ctccgcccac gcgctagaca tgacttttga ggtggatccc 21540 atggacgagc ccacccttct ttatgttttg tttgaagtct ttgacgtggt ccgtgtgcac 21600 cggccgcacc gcggcgtcat cgaaaccgtg tacctgcgca cgcccttctc ggccggcaac 21660 gccacaacat aaagaagcaa gcaacatcaa caacagctgc cgccatgggc tccagtgagc 21720 aggaactgaa agccattgtc aaagatcttg gttgtgggcc atattttttg ggcacctatg 21780 acaagcgctt tccaggcttt gtttctccac acaagctcgc ctgcgccata gtcaatacgg 21840 ccggtcgcga gactgggggc gtacactgga tggcctttgc ctggaacccg cactcaaaaa 21900 catgctacct ctttgagccc tttggctttt ctgaccagcg actcaagcag gtttaccagt 21960 ttgagtacga gtcactcctg cgccgtagcg ccattgcttc ttcccccgac cgctgtataa 22020 cgctggaaaa gtccacccaa agcgtacagg ggcccaactc ggccgcctgt ggactattct 22080 gctgcatgtt tctccacgcc tttgccaact ggccccaaac tcccatggat cacaacccca 22140 ccatgaacct tattaccggg gtacccaact ccatgctcaa cagtccccag gtacagccca 22200 ccctgcgtcg caaccaggaa cagctctaca gcttcctgga gcgccactcg ccctacttcc 22260 gcagccacag tgcgcagatt aggagcgcca cttctttttg tcacttgaaa aacatgtaaa 22320 aataatgtac tagagacact ttcaataaag gcaaatgctt ttatttgtac actctcgggt 22380 gattatttac ccccaccctt gccgtctgcg ccgtttaaaa atcaaagggg ttctgccgcg 22440 catcgctatg cgccactggc agggacacgt tgcgatactg gtgtttagtg ctccacttaa 22500 actcaggcac aaccatccgc ggcagctcgg tgaagttttc actccacagg ctgcgcacca 22560 tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa gtcgcagttg gggcctccgc 22620 cctgcgcgcg cgagttgcga tacacagggt tgcagcactg gaacactatc agcgccgggt 22680 ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc cgcgtccagg tcctccgcgt 22740 tgctcagggc gaacggagtc aactttggta gctgccttcc caaaaagggc gcgtgcccag 22800 gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg accgtgcccg gtctgggcgt 22860 taggatacag cgcctgcata aaagccttga tctgcttaaa agccacctga gcctttgcgc 22920 cttcagagaa gaacatgccg caagacttgc cggaaaactg attggccgga caggccgcgt 22980 cgtgcacgca gcaccttgcg tcggtgttgg agatctgcac cacatttcgg ccccaccggt 23040 tcttcacgat cttggccttg ctagactgct ccttcagcgc gcgctgcccg ttttcgctcg 23100 tcacatccat ttcaatcacg tgctccttat ttatcataat gcttccgtgt agacacttaa 23160 gctcgccttc gatctcagcg cagcggtgca gccacaacgc gcagcccgtg ggctcgtgat 23220 gcttgtaggt cacctctgca aacgactgca ggtacgcctg caggaatcgc cccatcatcg 23280 tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc gcggtgctcc tcgttcagcc 23340 aggtcttgca tacggccgcc agagcttcca cttggtcagg cagtagtttg aagttcgcct 23400 ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg cgcagcctcc atgcccttct 23460 cccacgcaga cacgatcggc acactcagcg ggttcatcac cgtaatttca ctttccgctt 23520 cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg cgccactggg tcgtcttcat 23580 tcagccgccg cactgtgcgc ttacctcctt tgccatgctt gattagcacc ggtgggttgc 23640 tgaaacccac catttgtagc gccacatctt ctctttcttc ctcgctgtcc acgattacct 23700 ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt ctttttcttc ttgggcgcaa 23760 tggccaaatc cgccgccgag gtcgatggcc gcgggctggg tgtgcgcggc accagcgcgt 23820 cttgtgatga gtcttcctcg tcctcggact cgatacgccg cctcatccgc ttttttgggg 23880 gcgcccgggg aggcggcggc gacggggacg gggacgacac gtcctccatg gttgggggac 23940 gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg ctgctcctct tcccgactgg 24000 ccatttcctt ctcctatagg cagaaaaaga tcatggagtc agtcgagaag aaggacagcc 24060 taaccgcccc ctctgagttc gccaccaccg cctccaccga tgccgccaac gcgcctacca 24120 ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt gattatcgag caggacccag 24180 gttttgtaag cgaagacgac gaggaccgct cagtaccaac agaggataaa aagcaagacc 24240 aggacaacgc agaggcaaac gaggaacaag tcgggcgggg ggacgaaagg catggcgact 24300 acctagatgt gggagacgac gtgctgttga agcatctgca gcgccagtgc gccattatct 24360 gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat agcggatgtc agccttgcct 24420 acgaacgcca cctattctca ccgcgcgtac cccccaaacg ccaagaaaac ggcacatgcg 24480 agcccaaccc gcgcctcaac ttctaccccg tatttgccgt gccagaggtg cttgccacct 24540 atcacatctt tttccaaaac tgcaagatac ccctatcctg ccgtgccaac cgcagccgag 24600 cggacaagca gctggccttg cggcagggcg ctgtcatacc tgatatcgcc tcgctcaacg 24660 aagtgccaaa aatctttgag ggtcttggac gcgacgagaa gcgcgcggca aacgctctgc 24720 aacaggaaaa cagcgaaaat gaaagtcact ctggagtgtt ggtggaactc gagggtgaca 24780 acgcgcgcct agccgtacta aaacgcagca tcgaggtcac ccactttgcc tacccggcac 24840 ttaacctacc ccccaaggtc atgagcacag tcatgagtga gctgatcgtg cgccgtgcgc 24900 agcccctgga gagggatgca aatttgcaag aacaaacaga ggagggccta cccgcagttg 24960 gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc tgccgacttg gaggagcgac 25020 gcaaactaat gatggccgca gtgctcgtta ccgtggagct tgagtgcatg cagcggttct 25080 ttgctgaccc ggagatgcag cgcaagctag aggaaacatt gcactacacc tttcgacagg 25140 gctacgtacg ccaggcctgc aagatctcca acgtggagct ctgcaacctg gtctcctacc 25200 ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct tcattccacg ctcaagggcg 25260 aggcgcgccg cgactacgtc cgcgactgcg tttacttatt tctatgctac acctggcaga 25320 cggccatggg cgtttggcag cagtgcttgg aggagtgcaa cctcaaggag ctgcagaaac 25380 tgctaaagca aaacttgaag gacctatgga cggccttcaa cgagcgctcc gtggccgcgc 25440 acctggcgga catcattttc cccgaacgcc tgcttaaaac cctgcaacag ggtctgccag 25500 acttcaccag tcaaagcatg ttgcagaact ttaggaactt tatcctagag cgctcaggaa 25560 tcttgcccgc cacctgctgt gcacttccta gcgactttgt gcccattaag taccgcgaat 25620 gccctccgcc gctttggggc cactgctacc ttctgcagct agccaactac cttgcctacc 25680 actctgacat aatggaagac gtgagcggtg acggtctact ggagtgtcac tgtcgctgca 25740 acctatgcac cccgcaccgc tccctggttt gcaattcgca gctgcttaac gaaagtcaaa 25800 ttatcggtac ctttgagctg cagggtccct cgcctgacga aaagtccgcg gctccggggt 25860 tgaaactcac tccggggctg tggacgtcgg cttaccttcg caaatttgta cctgaggact 25920 accacgccca cgagattagg ttctacgaag accaatcccg cccgccaaat gcggagctta 25980 ccgcctgcgt cattacccag ggccacattc ttggccaatt gcaagccatc aacaaagccc 26040 gccaagagtt tctgctacga aagggacggg gggtttactt ggacccccag tccggcgagg 26100 agctcaaccc aatccccccg ccgccgcagc cctatcagca gcagccgcgg gcccttgctt 26160 cccaggatgg cacccaaaaa gaagctgcag ctgccgccgc cacccacgga cgaggaggaa 26220 tactgggaca gtcaggcaga ggaggttttg gacgaggagg aggaggacat gatggaagac 26280 tgggagagcc tagacgagga agcttccgag gtcgaagagg tgtcagacga aacaccgtca 26340 ccctcggtcg cattcccctc gccggcgccc cagaaatcgg caaccggttc cagcatggct 26400 acaacctccg ctcctcaggc gccgccggca ctgcccgttc gccgacccaa ccgtagatgg 26460 gacaccactg gaaccagggc cggtaagtcc aagcagccgc cgccgttagc ccaagagcaa 26520 caacagcgcc aaggctaccg ctcatggcgc gggcacaaga acgccatagt tgcttgcttg 26580 caagactgtg ggggcaacat ctccttcgcc cgccgctttc ttctctacca tcacggcgtg 26640 gccttccccc gtaacatcct gcattactac cgtcatctct acagcccata ctgcaccggc 26700 ggcagcggca gcggcagcaa cagcagcggc cacacagaag caaaggcgac cggatagcaa 26760 gactctgaca aagcccaaga aatccacagc ggcggcagca gcaggaggag gagcgctgcg 26820 tctggcgccc aacgaacccg tatcgacccg cgagcttaga aacaggattt ttcccactct 26880 gtatgctata tttcaacaga gcaggggcca agaacaagag ctgaaaataa aaaacaggtc 26940 tctgcgatcc ctcacccgca gctgcctgta tcacaaaagc gaagatcagc ttcggcgcac 27000 gctggaagac gcggaggctc tcttcagtaa atactgcgcg ctgactctta aggactagtt 27060 tcgcgccctt tctcaaattt aagcgcgaaa actacgtcat ctccagcggc cacacccggc 27120 gccagcacct gtcgtcagcg ccatttatga gcaaggaaat tcccacgccc tacatgtgga 27180 gttaccagcc acaaatggga cttgcggctg gagctgccca agactactca acccgaataa 27240 actacatgag cgcgggaccc cacatgatat cccgggtcaa cggaatacgc gcccaccgaa 27300 accgaattct cctggaacag gcggctatta ccaccacacc tcgtaataac cttaatcccc 27360 gtagttggcc cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc 27420 ccagagacgc ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct 27480 ttcgtcacag ggtgcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag 27540 gtattcagct caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat 27600 ttcagatcgg cggcgccggc cgctcttcat tcacgcctcg tcaggcaatc ctaactctgc 27660 agacctcgtc ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt 27720 ttgtgccatc ggtctacttt aaccccttct cgggacctcc cggccactat ccggatcaat 27780 ttattcctaa ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg 27840 gagaggcaga gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg 27900 cccgcgactc cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg 27960 cgcacggcgt ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta 28020 cccagcgccc cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca 28080 actgtcctaa ccctggatta catcaagatc tttgttgcca tctctgtgct gagtataata 28140 aatacagaaa ttaaaatata ctggggctcc tatcgccatc ctgtaaacgc caccgtcttc 28200 acccgcccaa gcaaaccaag gcgaacctta cctggtactt ttaacatctc tccctctgtg 28260 atttacaaca gtttcaaccc agacggagtg agtctacgag agaacctctc cgagctcagc 28320 tactccatca gaaaaaacac caccctcctt acctgccggg aacgtacgag tgcgtcaccg 28380 gccgctgcac cacacctacc gcctgaccgt aaaccagact ttttccggac agacctcaat 28440 aactctgttt accagaacag gaggtgagct tagaaaaccc ttagggtatt aggccaaagg 28500 cgcagctact gtggggttta tgaacaattc aagcaactct acgggctatt ctaattcagg 28560 tttctctaga atcggggttg gggttattct ctgtcttgtg attctcttta ttcttatact 28620 aacgcttctc tgcctaaggc tcgccgcctg ctgtgtgcac atttgcattt attgtcagct 28680 ttttaaacgc tggggtcgcc acccaagatg attaggtaca taatcctagg tttactcacc 28740 cttgcgtcag cccacggtac cacccaaaag gtggatttta aggagccagc ctgtaatgtt 28800 acattcgcag ctgaagctaa tgagtgcacc actcttataa aatgcaccac agaacatgaa 28860 aagctgctta ttcgccacaa aaacaaaatt ggcaagtatg ctgtttatgc tatttggcag 28920 ccaggtgaca ctacagagta taatgttaca gttttccagg gtaaaagtca taaaactttt 28980 atgtatactt ttccatttta tgaaatgtgc gacattacca tgtacatgag caaacagtat 29040 aagttgtggc ccccacaaaa ttgtgtggaa aacactggca ctttctgctg cactgctatg 29100 ctaattacag tgctcgcttt ggtctgtacc ctactctata ttaaatacaa aagcagacgc 29160 agctttattg aggaaaagaa aatgccttaa tttactaagt tacaaagcta atgtcaccac 29220 taactgcttt actcgctgct tgcaaaacaa attcaaaaag ttagcattat aattagaata 29280 ggatttaaac cccccggtca tttcctgctc aataccattc ccctgaacaa ttgactctat 29340 gtgggatatg ctccagcgct acaaccttga agtcaggctt cctggatgtc agcatctgac 29400 tttggccagc acctgtcccg cggatttgtt ccagtccaac tacagcgacc caccctaaca 29460 gagatgacca acacaaccaa cgcggccgcc gctaccggac ttacatctac cacaaataca 29520 ccccaagttt ctgcctttgt caataactgg gataacttgg gcatgtggtg gttctccata 29580 gcgcttatgt ttgtatgcct tattattatg tggctcatct gctgcctaaa gcgcaaacgc 29640 gcccgaccac ccatctatag tcccatcatt gtgctacacc caaacaatga tggaatccat 29700 agattggacg gactgaaaca catgttcttt tctcttacag tatgattaaa tgagacatga 29760 ttcctcgagt ttttatatta ctgacccttg ttgcgctttt ttgtgcgtgc tccacattgg 29820 ctgcggtttc tcacatcgaa gtagactgca ttccagcctt cacagtctat ttgctttacg 29880 gatttgtcac cctcacgctc atctgcagcc tcatcactgt ggtcatcgcc tttatccagt 29940 gcattgactg ggtctgtgtg cgctttgcat atctcagaca ccatccccag tacagggaca 30000 ggactatagc tgagcttctt agaattcttt aattatgaaa tttactgtga cttttctgct 30060 gattatttgc accctatctg cgttttgttc cccgacctcc aagcctcaaa gacatatatc 30120 atgcagattc actcgtatat ggaatattcc aagttgctac aatgaaaaaa gcgatctttc 30180 cgaagcctgg ttatatgcaa tcatctctgt tatggtgttc tgcagtacca tcttagccct 30240 agctatatat ccctaccttg acattggctg gaacgcaata gatgccatga accacccaac 30300 tttccccgcg cccgctatgc ttccactgca acaagttgtt gccggcggct ttgtcccagc 30360 caatcagcct cgcccacctt ctcccacccc cactgaaatc agctacttta atctaacagg 30420 aggagatgac tgacacccta gatctagaaa tggacggaat tattacagag cagcgcctgc 30480 tagaaagacg cagggcagcg gccgagcaac agcgcatgaa tcaagagctc caagacatgg 30540 ttaacttgca ccagtgcaaa aggggtatct tttgtctggt aaagcaggcc aaagtcacct 30600 acgacagtaa taccaccgga caccgcctta gctacaagtt gccaaccaag cgtcagaaat 30660 tggtggtcat ggtgggagaa aagcccatta ccataactca gcactcggta gaaaccgaag 30720 gctgcattca ctcaccttgt caaggacctg aggatctctg cacccttatt aagaccctgt 30780 gcggtctcaa agatcttatt ccctttaact aataaaaaaa aataataaag catcacttac 30840 ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc 30900 cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg 30960 tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag 31020 cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt 31080 cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt 31140 ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt 31200 gcgctcaaaa tgggcaacgg cctctctctg gacgaggccg gcaaccttac ctcccaaaat 31260 gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct 31320 gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc 31380 gcgggcaaca cactcaccat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt 31440 agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca 31500 ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact 31560 actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa 31620 ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac tttgaccgta 31680 gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc 31740 ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat 31800 tctcaaaaca gacgccttat acttgatgtt agttatccgt ttgatgctca aaaccaacta 31860 aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac 31920 tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac 31980 ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat 32040 gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc 32100 catggcctag aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt 32160 tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg 32220 accacaccag ctccatctcc taactgtaga ctaaatgcag agaaagatgc taaactcact 32280 ttggtcttaa caaaatgtgg cagtcaaata cttgctacag tttcagtttt ggctgttaaa 32340 ggcagtttgg ctccaatatc tggaacagtt caaagtgctc atcttattat aagatttgac 32400 gaaaatggag tgctactaaa caattccttc ctggacccag aatattggaa ctttagaaat 32460 ggagatctta ctgaaggcac agcctataca aacgctgttg gatttatgcc taacctatca 32520 gcttatccaa aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca agtttactta 32580 aacggagaca aaactaaacc tgtaacacta accattacac taaacggtac acaggaaaca 32640 ggagacacaa ctccaagtgc atactctatg tcattttcat gggactggtc tggccacaac 32700 tacattaatg aaatatttgc cacatcctct tacacttttt catacattgc ccaagaataa 32760 agaatcgttt gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcaagtca 32820 tttttcattc agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa 32880 tcaaactcac agaaccctag tattcaacct gccacctccc tcccaacaca cagagtacac 32940 agtcctttct ccccggctgg ccttaaaaag catcatatca tgggtaacag acatattctt 33000 aggtgttata ttccacacgg tttcctgtcg agccaaacgc tcatcagtga tattaataaa 33060 ctccccgggc agctcactta agttcatgtc gctgtccagc tgctgagcca caggctgctg 33120 tccaacttgc ggttgcttaa cgggcggcga aggagaagtc cacgcctaca tgggggtaga 33180 gtcataatcg tgcatcagga tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg 33240 ccgccgccgc tccgtcctgc aggaatacaa catggcagtg gtctcctcag cgatgattcg 33300 caccgcccgc agcataaggc gccttgtcct ccgggcacag cagcgcaccc tgatctcact 33360 taaatcagca cagtaactgc agcacagcac cacaatattg ttcaaaatcc cacagtgcaa 33420 ggcgctgtat ccaaagctca tggcggggac cacagaaccc acgtggccat cataccacaa 33480 gcgcaggtag attaagtggc gacccctcat aaacacgctg gacataaaca ttacctcttt 33540 tggcatgttg taattcacca cctcccggta ccatataaac ctctgattaa acatggcgcc 33600 atccaccacc atcctaaacc agctggccaa aacctgcccg ccggctatac actgcaggga 33660 accgggactg gaacaatgac agtggagagc ccaggactcg taaccatgga tcatcatgct 33720 cgtcatgata tcaatgttgg cacaacacag gcacacgtgc atacacttcc tcaggattac 33780 aagctcctcc cgcgttagaa ccatatccca gggaacaacc cattcctgaa tcagcgtaaa 33840 tcccacactg cagggaagac ctcgcacgta actcacgttg tgcattgtca aagtgttaca 33900 ttcgggcagc agcggatgat cctccagtat ggtagcgcgg gtttctgtct caaaaggagg 33960 tagacgatcc ctactgtacg gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt 34020 catgccaaat ggaacgccgg acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt 34080 gacaaacaga tctgcgtctc cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt 34140 atatccactc tctcaaagca tccaggcgcc ccctggcttc gggttctatg taaactcctt 34200 catgcgccgc tgccctgata acatccacca ccgcagaata agccacaccc agccaaccta 34260 cacattcgtt ctgcgagtca cacacgggag gagcgggaag agctggaaga accatgtttt 34320 tttttttatt ccaaaagatt atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc 34380 tcccctccgg tggcgtggtc aaactctaca gccaaagaac agataatggc atttgtaaga 34440 tgttgcacaa tggcttccaa aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta 34500 aacccttcag ggtgaatctc ctctataaac attccagcac cttcaaccat gcccaaataa 34560 ttctcatctc gccaccttct caatatatct ctaagcaaat cccgaatatt aagtccggcc 34620 attgtaaaaa tctgctccag agcgccctcc accttcagcc tcaagcagcg aatcatgatt 34680 gcaaaaattc aggttcctca cagacctgta taagattcaa aagcggaaca ttaacaaaaa 34740 taccgcgatc ccgtaggtcc cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac 34800 ggaccagcgc ggccacttcc ccgccaggaa ccatgacaaa agaacccaca ctgattatga 34860 cacgcatact cggagctatg ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg 34920 gcgatataaa atgcaaggtg ctgctcaaaa aatcaggcaa agcctcgcgc aaaaaagaaa 34980 gcacatcgta gtcatgctca tgcagataaa ggcaggtaag ctccggaacc accacagaaa 35040 aagacaccat ttttctctca aacatgtctg cgggtttctg cataaacaca aaataaaata 35100 acaaaaaaac atttaaacat tagaagcctg tcttacaaca ggaaaaacaa cccttataag 35160 cataagacgg actacggcca tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa 35220 aagcaccacc gacagctcct cggtcatgtc cggagtcata atgtaagact cggtaaacac 35280 atcaggttga ttcacatcgg tcagtgctaa aaagcgaccg aaatagcccg ggggaataca 35340 tacccgcagg cgtagagaca acattacagc ccccatagga ggtataacaa aattaatagg 35400 agagaaaaac acataaacac ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg 35460 ctccagaaca acatacagcg cttccacagc ggcagccata acagtcagcc ttaccagtaa 35520 aaaagaaaac ctattaaaaa aacaccactc gacacggcac cagctcaatc agtcacagtg 35580 taaaaaaggg ccaagtgcag agcgagtata tataggacta aaaaatgacg taacggttaa 35640 agtccacaaa aaacacccag aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa 35700 aaacccacaa cttcctcaaa tcgtcacttc cgttttccca cgttacgtca cttcccattt 35760 taagaaaact acaattccca acacatacaa gttactccgc cctaaaacct acgtcacccg 35820 ccccgttccc acgccccgcg ccacgtcaca aactccaccc cctcattatc atattggctt 35880 caatccaaaa taaggtatat tattgatgat g 35911 <210> 22 <211> 35632 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO296) <400> 22 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgaccgaaga aatggccgcc agtcttttgg accagctgat 600 cgaagaggta ctggctgata atcttccacc tcctagccat tttgaaccac ctacccttca 660 cgaactgcat gatttagacg tgacggcccc cgaagatccc aacgaggagg cggtttcgca 720 gatttttccc gactctgtaa tgttggcggt gcaggaaggg attgacttac tcacttttcc 780 gccggcgccc ggttctccgg agccgcctca cctttcccgg cagcccgagc agccggagca 840 gagagccttg ggtccggttt ctatgccaaa ccttgtaccg gaggtgatcg atcttaccgg 900 ccacgaggct ggctttccac ccagtgacga cgaggatgaa gagggtgagg agtttgtgtt 960 agattatgtg gagcaccccg ggcacggttg caggtcttgt cattatcacc ggaggaatac 1020 gggggaccca gatattatgt gttcgctttg ctatatgagg acctgtggca tgtttgtcta 1080 cagtaagtga aaattatggg cagtgggtga tagagtggtg ggtttggtgt ggtaattttt 1140 tttttaattt ttacagtttt gtggtttaaa gaattttgta ttgtgatttt tttaaaaggt 1200 cctgtgtctg aacctgagcc tgagcccgag ccagaaccgg agcctgcaag acctacccgc 1260 cgtcctaaaa tggcgcctgc tatcctgaga cgcccgacat cacctgtgtc tagagaatgc 1320 aatagtagta cggatagctg tgactccggt ccttctaaca cacctcctga gatacacccg 1380 gtggtcccgc tgtgccccat taaaccagtt gccgtgagag ttggtgggcg tcgccaggct 1440 gtggaatgta tcgaggactt gcttaacgag cctgggcaac ctttggactt gagctgtaaa 1500 cgccccaggc cataaggtgt aaacctgtga ttgcgtgtgt ggttaacgcc tttgtttgct 1560 gaatgagttg atgtaagttt aataaagggt gagataatgt ttaacttgca tggcgtgtta 1620 aatggggcgg ggcttaaagg gtatataatg cgccgtgggc taatcttggt tacatctgac 1680 ctcatggagg cttgggagtg tttggaagat ttttctgctg tgcgtaactt gctggaacag 1740 agctctaaca gtacctcttg gttttggagg tttctgtggg gctcatccca ggcaaagtta 1800 gtctgcagaa ttaaggagga ttacaagtgg gaatttgaag agcttttgaa atcctgtggt 1860 gagctgtttg attctttgaa tctgggtcac caggcgcttt tccaagagaa ggtcatcaag 1920 actttggatt tttccacacc ggggcgcgct gcggctgctg ttgctttttt gagttttata 1980 aaggataaat ggagcgaaga aacccatctg agcggggggt acctgctgga ttttctggcc 2040 atgcatctgt ggagagcggt tgtgagacac aagaatcgcc tgctactgtt gtcttccgtc 2100 cgcccggcga taataccgac ggaggagcag cagcagcagc aggaggaagc caggcggcgg 2160 cggcaggagc agagcccatg gaacccgaga gccggcctgg accctcggga atgaatgttg 2220 tacaggtggc tgaactgtat ccagaactga gacgcatttt gacaattaca gaggatgggc 2280 aggggctaaa gggggtaaag agggagcggg gggcttgtga ggctacagag gaggctagga 2340 atctagcttt tagcttaatg accagacacc gtcctgagtg tattactttt caacagatca 2400 aggataattg cgctaatgag cttgatctgc tggcgcagaa gtattccata gagcagctga 2460 ccacttactg gctgcagcca ggggatgatt ttgaggaggc tattagggta tatgcaaagg 2520 tggcacttag gccagattgc aagtacaaga tcagcaaact tgtaaatatc aggaattgtt 2580 gctacatttc tgggaacggg gccgaggtgg agatagatac ggaggatagg gtggccttta 2640 gatgtagcat gataaatatg tggccggggg tgcttggcat ggacggggtg gttattatga 2700 atgtaaggtt tactggcccc aattttagcg gtacggtttt cctggccaat accaacctta 2760 tcctacacgg tgtaagcttc tatgggttta acaatacctg tgtggaagcc tggaccgatg 2820 taagggttcg gggctgtgcc ttttactgct gctggaaggg ggtggtgtgt cgccccaaaa 2880 gcagggcttc aattaagaaa tgcctctttg aaaggtgtac cttgggtatc ctgtctgagg 2940 gtaactccag ggtgcgccac aatgtggcct ccgactgtgg ttgcttcatg ctagtgaaaa 3000 gcgtggctgt gattaagcat aacatggtat gtggcaactg cgaggacagg gcctctcaga 3060 tgctgacctg ctcggacggc aactgtcacc tgctgaagac cattcacgta gccagccact 3120 ctcgcaaggc ctggccagtg tttgagcata acatactgac ccgctgttcc ttgcatttgg 3180 gtaacaggag gggggtgttc ctaccttacc aatgcaattt gagtcacact aagatattgc 3240 ttgagcccga gagcatgtcc aaggtgaacc tgaacggggt gtttgacatg accatgaaga 3300 tctggaaggt gctgaggtac gatgagaccc gcaccaggtg cagaccctgc gagtgtggcg 3360 gtaaacatat taggaaccag cctgtgatgc tggatgtgac cgaggagctg aggcccgatc 3420 acttggtgct ggcctgcacc cgcgctgagt ttggctctag cgatgaagat acagattgag 3480 gtactgaaat gtgtgggcgt ggcttaaggg tgggaaagaa tatataaggt gggggtctta 3540 tgtagttttg tatctgtttt gcagcagccg ccgccgccat gagcaccaac tcgtttgatg 3600 gaagcattgt gagctcatat ttgacaacgc gcatgccccc atgggccggg gtgcgtcaga 3660 atgtgatggg ctccagcatt gatggtcgcc ccgtcctgcc cgcaaactct actaccttga 3720 cctacgagac cgtgtctgga acgccgttgg agactgcagc ctccgccgcc gcttcagccg 3780 ctgcagccac cgcccgcggg attgtgactg actttgcttt cctgagcccg cttgcaagca 3840 gtgcagcttc ccgttcatcc gcccgcgatg acaagttgac ggctcttttg gcacaattgg 3900 attctttgac ccgggaactt aatgtcgttt ctcagcagct gttggatctg cgccagcagg 3960 tttctgccct gaaggcttcc tcccctccca atgcggttta aaacataaat aaaaaaccag 4020 actctgtttg gatttggatc aagcataagt gtcttgctgt ctttatttag gggttttgcg 4080 cgcgcggtag gcccgggacc agcggtctcg gtcgttgagg gtcctgtgta ttttttccag 4140 gacgtggtaa aggtgactct ggatgttcag atacatgggc ataagcccgt ctctggggtg 4200 gaggtagcac cactgcagag cttcatgctg cggggtggtg ttgtagatga tccagtcgta 4260 gcaggagcgc tgggcgtggt gcctaaaaat gtctttcagt agcaagctga ttgccagggg 4320 caggcccttg gtgtaagtgt ttacaaagcg gttaagctgg gatgggtgca tacgtgggga 4380 tatgagatgc atcttggact gtatttttag gttggctatg ttcccagcca tatccctccg 4440 gggattcatg ttgtgcagaa ccaccagcac agtgtatccg gtgcacttgg gaaatttgtc 4500 atgtagctta gaaggaaatg cgtggaagaa cttggagacg cccttgtgac ctccaagatt 4560 ttccatgcat tcgtccataa tgatggcaat gggcccacgg gcggcggcct gggcgaagat 4620 atttctggga tcactaacgt catagttgtg ttccaggatg agatcgtcat aggccatttt 4680 tacaaagcgc gggcggaggg tgccagactg cggtataatg gttccatccg gcccaggggc 4740 gtagttaccc tcacagattt gcatttccca cgctttgagt tcagatgggg ggatcatgtc 4800 tacctgcggg gcgatgaaga aaacggtttc cggggtaggg gagatcagct gggaagaaag 4860 caggttcctg agcagctgcg acttaccgca gccggtgggc ccgtaaatca cacctattac 4920 cgggtgcaac tggtagttaa gagagctgca gctgccgtca tccctgagca ggggggccac 4980 ttcgttaagc atgtccctga ctcgcatgtt ttccctgacc aaatccgcca gaaggcgctc 5040 gccgcccagc gatagcagtt cttgcaagga agcaaagttt ttcaacggtt tgagaccgtc 5100 cgccgtaggc atgcttttga gcgtttgacc aagcagttcc aggcggtccc acagctcggt 5160 cacctgctct acggcatctc gatccagcat atctcctcgt ttcgcgggtt ggggcggctt 5220 tcgctgtacg gcagtagtcg gtgctcgtcc agacgggcca gggtcatgtc tttccacggg 5280 cgcagggtcc tcgtcagcgt agtctgggtc acggtgaagg ggtgcgctcc gggctgcgcg 5340 ctggccaggg tgcgcttgag gctggtcctg ctggtgctga agcgctgccg gtcttcgccc 5400 tgcgcgtcgg ccaggtagca tttgaccatg gtgtcatagt ccagcccctc cgcggcgtgg 5460 cccttggcgc gcagcttgcc cttggaggag gcgccgcacg aggggcagtg cagacttttg 5520 agggcgtaga gcttgggcgc gagaaatacc gattccgggg agtaggcatc cgcgccgcag 5580 gccccgcaga cggtctcgca ttccacgagc caggtgagct ctggccgttc ggggtcaaaa 5640 accaggtttc ccccatgctt tttgatgcgt ttcttacctc tggtttccat gagccggtgt 5700 ccacgctcgg tgacgaaaag gctgtccgtg tccccgtata cagacttgag aggcctgtcc 5760 tcgagcggtg ttccgcggtc ctcctcgtat agaaactcgg accactctga gacaaaggct 5820 cgcgtccagg ccagcacgaa ggaggctaag tgggaggggt agcggtcgtt gtccactagg 5880 gggtccactc gctccagggt gtgaagacac atgtcgccct cttcggcatc aaggaaggtg 5940 attggtttgt aggtgtaggc cacgtgaccg ggtgttcctg aaggggggct ataaaagggg 6000 gtgggggcgc gttcgtcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg 6060 ggtgagtact ccctctgaaa agcgggcatg acttctgcgc taagattgtc agtttccaaa 6120 aacgaggagg atttgatatt cacctggccc gcggtgatgc ctttgagggt ggccgcatcc 6180 atctggtcag aaaagacaat ctttttgttg tcaagcttgg tggcaaacga cccgtagagg 6240 gcgttggaca gcaacttggc gatggagcgc agggtttggt ttttgtcgcg atcggcgcgc 6300 tccttggccg cgatgtttag ctgcacgtat tcgcgcgcaa cgcaccgcca ttcgggaaag 6360 acggtggtgc gctcgtcggg caccaggtgc acgcgccaac cgcggttgtg cagggtgaca 6420 aggtcaacgc tggtggctac ctctccgcgt aggcgctcgt tggtccagca gaggcggccg 6480 cccttgcgcg agcagaatgg cggtaggggg tctagctgcg tctcgtccgg ggggtctgcg 6540 tccacggtaa agaccccggg cagcaggcgc gcgtcgaagt agtctatctt gcatccttgc 6600 aagtctagcg cctgctgcca tgcgcgggcg gcaagcgcgc gctcgtatgg gttgagtggg 6660 ggaccccatg gcatggggtg ggtgagcgcg gaggcgtaca tgccgcaaat gtcgtaaacg 6720 tagaggggct ctctgagtat tccaagatat gtagggtagc atcttccacc gcggatgctg 6780 gcgcgcacgt aatcgtatag ttcgtgcgag ggagcgagga ggtcgggacc gaggttgcta 6840 cgggcgggct gctctgctcg gaagactatc tgcctgaaga tggcatgtga gttggatgat 6900 atggttggac gctggaagac gttgaagctg gcgtctgtga gacctaccgc gtcacgcacg 6960 aaggaggcgt aggagtcgcg cagcttgttg accagctcgg cggtgacctg cacgtctagg 7020 gcgcagtagt ccagggtttc cttgatgatg tcatacttat cctgtccctt ttttttccac 7080 agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt actcttggat cggaaacccg 7140 tcggcctccg aacggtaaga gcctagcatg tagaactggt tgacggcctg gtaggcgcag 7200 catccctttt ctacgggtag cgcgtatgcc tgcgcggcct tccggagcga ggtgtgggtg 7260 agcgcaaagg tgtccctgac catgactttg aggtactggt atttgaagtc agtgtcgtcg 7320 catccgccct gctcccagag caaaaagtcc gtgcgctttt tggaacgcgg atttggcagg 7380 gcgaaggtga catcgttgaa gagtatcttt cccgcgcgag gcataaagtt gcgtgtgatg 7440 cggaagggtc ccggcacctc ggaacggttg ttaattacct gggcggcgag cacgatctcg 7500 tcaaagccgt tgatgttgtg gcccacaatg taaagttcca agaagcgcgg gatgcccttg 7560 atggaaggca attttttaag ttcctcgtag gtgagctctt caggggagct gagcccgtgc 7620 tctgaaaggg cccagtctgc aagatgaggg ttggaagcga cgaatgagct ccacaggtca 7680 cgggccatta gcatttgcag gtggtcgcga aaggtcctaa actggcgacc tatggccatt 7740 ttttctgggg tgatgcagta gaaggtaagc gggtcttgtt cccagcggtc ccatccaagg 7800 ttcgcggcta ggtctcgcgc ggcagtcact agaggctcat ctccgccgaa cttcatgacc 7860 agcatgaagg gcacgagctg cttcccaaag gcccccatcc aagtataggt ctctacatcg 7920 taggtgacaa agagacgctc ggtgcgagga tgcgagccga tcgggaagaa ctggatctcc 7980 cgccaccaat tggaggagtg gctattgatg tggtgaaagt agaagtccct gcgacgggcc 8040 gaacactcgt gctggctttt gtaaaaacgt gcgcagtact ggcagcggtg cacgggctgt 8100 acatcctgca cgaggttgac ctgacgaccg cgcacaagga agcagagtgg gaatttgagc 8160 ccctcgcctg gcgggtttgg ctggtggtct tctacttcgg ctgcttgtcc ttgaccgtct 8220 ggctgctcga ggggagttac ggtggatcgg accaccacgc cgcgcgagcc caaagtccag 8280 atgtccgcgc gcggcggtcg gagcttgatg acaacatcgc gcagatggga gctgtccatg 8340 gtctggagct cccgcggcgt caggtcaggc gggagctcct gcaggtttac ctcgcataga 8400 cgggtcaggg cgcgggctag atccaggtga tacctaattt ccaggggctg gttggtggcg 8460 gcgtcgatgg cttgcaagag gccgcatccc cgcggcgcga ctacggtacc gcgcggcggg 8520 cggtgggccg cgggggtgtc cttggatgat gcatctaaaa gcggtgacgc gggcgagccc 8580 ccggaggtag ggggggctcc ggacccgccg ggagaggggg caggggcacg tcggcgccgc 8640 gcgcgggcag gagctggtgc tgcgcgcgta ggttgctggc gaacgcgacg acgcggcggt 8700 tgatctcctg aatctggcgc ctctgcgtga agacgacggg cccggtgagc ttgagcctga 8760 aagagagttc gacagaatca atttcggtgt cgttgacggc ggcctggcgc aaaatctcct 8820 gcacgtctcc tgagttgtct tgataggcga tctcggccat gaactgctcg atctcttcct 8880 cctggagatc tccgcgtccg gctcgctcca cggtggcggc gaggtcgttg gaaatgcggg 8940 ccatgagctg cgagaaggcg ttgaggcctc cctcgttcca gacgcggctg tagaccacgc 9000 ccccttcggc atcgcgggcg cgcatgacca cctgcgcgag attgagctcc acgtgccggg 9060 cgaagacggc gtagtttcgc aggcgctgaa agaggtagtt gagggtggtg gcggtgtgtt 9120 ctgccacgaa gaagtacata acccagcgtc gcaacgtgga ttcgttgata tcccccaagg 9180 cctcaaggcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc 9240 gcgccgacac ggttaactcc tcctccagaa gacggatgag ctcggcgaca gtgtcgcgca 9300 cctcgcgctc aaaggctaca ggggcctctt cttcttcttc aatctcctct tccataaggg 9360 cctccccttc ttcttcttct ggcggcggtg ggggaggggg gacacggcgg cgacgacggc 9420 gcaccgggag gcggtcgaca aagcgctcga tcatctcccc gcggcgacgg cgcatggtct 9480 cggtgacggc gcggccgttc tcgcgggggc gcagttggaa gacgccgccc gtcatgtccc 9540 ggttatgggt tggcgggggg ctgccatgcg gcagggatac ggcgctaacg atgcatctca 9600 acaattgttg tgtaggtact ccgccgccga gggacctgag cgagtccgca tcgaccggat 9660 cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc gcaaggtagg ctgagcaccg 9720 tggcgggcgg cagcgggcgg cggtcggggt tgtttctggc ggaggtgctg ctgatgatgt 9780 aattaaagta ggcggtcttg agacggcgga tggtcgacag aagcaccatg tccttgggtc 9840 cggcctgctg aatgcgcagg cggtcggcca tgccccaggc ttcgttttga catcggcgca 9900 ggtctttgta gtagtcttgc atgagccttt ctaccggcac ttcttcttct ccttcctctt 9960 gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga gtttggccgt aggtggcgcc 10020 ctcttcctcc catgcgtgtg accccgaagc ccctcatcgg ctgaagcagg gctaggtcgg 10080 cgacaacgcg ctcggctaat atggcctgct gcacctgcgt gagggtagac tggaagtcat 10140 ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt gtaagtgcag ttggccataa 10200 cggaccagtt aacggtctgg tgacccggct gcgagagctc ggtgtacctg agacgcgagt 10260 aagccctcga gtcaaatacg tagtcgttgc aagtccgcac caggtactgg tatcccacca 10320 aaaagtgcgg cggcggctgg cggtagaggg gccagcgtag ggtggccggg gctccggggg 10380 cgagatcttc caacataagg cgatgatatc cgtagatgta cctggacatc caggtgatgc 10440 cggcggcggt ggtggaggcg cgcggaaagt cgcggacgcg gttccagatg ttgcgcagcg 10500 gcaaaaagtg ctccatggtc gggacgctct ggccggtcag gcgcgcgcaa tcgttgacgc 10560 tctagaccgt gcaaaaggag agcctgtaag cgggcactct tccgtggtct ggtggataaa 10620 ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc cgtatccggc cgtccgccgt 10680 gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga caacggggga 10740 gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc gctagctttt ttggccactg 10800 gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc tcgctccctg 10860 tagccggagg gttattttcc aagggttgag tcgcgggacc cccggttcga gtctcggacc 10920 ggccggactg cggcgaacgg gggtttgcct ccccgtcatg caagaccccg cttgcaaatt 10980 cctccggaaa cagggacgag cccctttttt gcttttccca gatgcatccg gtgctgcggc 11040 agatgcgccc ccctcctcag cagcggcaag agcaagagca gcggcagaca tgcagggcac 11100 cctcccctcc tcctaccgcg tcaggagggg cgacatccgc ggttgacgcg gcagcagatg 11160 gtgattacga acccccgcgg cgccgggccc ggcactacct ggacttggag gagggcgagg 11220 gcctggcgcg gctaggagcg ccctctcctg agcggtaccc aagggtgcag ctgaagcgtg 11280 atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg cgaccgcgag ggagaggagc 11340 ccgaggagat gcgggatcga aagttccacg cagggcgcga gctgcggcat ggcctgaatc 11400 gcgagcggtt gctgcgcgag gaggactttg agcccgacgc gcgaaccggg attagtcccg 11460 cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata cgagcagacg gtgaaccagg 11520 agattaactt tcaaaaaagc tttaacaacc acgtgcgtac gcttgtggcg cgcgaggagg 11580 tggctatagg actgatgcat ctgtgggact ttgtaagcgc gctggagcaa aacccaaata 11640 gcaagccgct catggcgcag ctgttcctta tagtgcagca cagcagggac aacgaggcat 11700 tcagggatgc gctgctaaac atagtagagc ccgagggccg ctggctgctc gatttgataa 11760 acatcctgca gagcatagtg gtgcaggagc gcagcttgag cctggctgac aaggtggccg 11820 ccatcaacta ttccatgctt agcctgggca agttttacgc ccgcaagata taccataccc 11880 cttacgttcc catagacaag gaggtaaaga tcgaggggtt ctacatgcgc atggcgctga 11940 aggtgcttac cttgagcgac gacctgggcg tttatcgcaa cgagcgcatc cacaaggccg 12000 tgagcgtgag ccggcggcgc gagctcagcg accgcgagct gatgcacagc ctgcaaaggg 12060 ccctggctgg cacgggcagc ggcgatagag aggccgagtc ctactttgac gcgggcgctg 12120 acctgcgctg ggccccaagc cgacgcgccc tggaggcagc tggggccgga cctgggctgg 12180 cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga ggaatatgac gaggacgatg 12240 agtacgagcc agaggacggc gagtactaag cggtgatgtt tctgatcaga tgatgcaaga 12300 cgcaacggac ccggcggtgc gggcggcgct gcagagccag ccgtccggcc ttaactccac 12360 ggacgactgg cgccaggtca tggaccgcat catgtcgctg actgcgcgca atcctgacgc 12420 gttccggcag cagccgcagg ccaaccggct ctccgcaatt ctggaagcgg tggtcccggc 12480 gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta aacgcgctgg ccgaaaacag 12540 ggccatccgg cccgacgagg ccggcctggt ctacgacgcg ctgcttcagc gcgtggctcg 12600 ttacaacagc ggcaacgtgc agaccaacct ggaccggctg gtgggggatg tgcgcgaggc 12660 cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg ggctccatgg ttgcactaaa 12720 cgccttcctg agtacacagc ccgccaacgt gccgcgggga caggaggact acaccaactt 12780 tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa agtgaggtgt accagtctgg 12840 gccagactat tttttccaga ccagtagaca aggcctgcag accgtaaacc tgagccaggc 12900 tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc acaggcgacc gcgcgaccgt 12960 gtctagcttg ctgacgccca actcgcgcct gttgctgctg ctaatagcgc ccttcacgga 13020 cagtggcagc gtgtcccggg acacatacct aggtcacttg ctgacactgt accgcgaggc 13080 cataggtcag gcgcatgtgg acgagcatac tttccaggag attacaagtg tcagccgcgc 13140 gctggggcag gaggacacgg gcagcctgga ggcaacccta aactacctgc tgaccaaccg 13200 gcggcagaag atcccctcgt tgcacagttt aaacagcgag gaggagcgca ttttgcgcta 13260 cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg gtaacgccca gcgtggcgct 13320 ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc tcaaaccggc cgtttatcaa 13380 ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac cccgagtatt tcaccaatgc 13440 catcttgaac ccgcactggc taccgccccc tggtttctac accgggggat tcgaggtgcc 13500 cgagggtaac gatggattcc tctgggacga catagacgac agcgtgtttt ccccgcaacc 13560 gcagaccctg ctagagttgc aacagcgcga gcaggcagag gcggcgctgc gaaaggaaag 13620 cttccgcagg ccaagcagct tgtccgatct aggcgctgcg gccccgcggt cagatgctag 13680 tagcccattt ccaagcttga tagggtctct taccagcact cgcaccaccc gcccgcgcct 13740 gctgggcgag gaggagtacc taaacaactc gctgctgcag ccgcagcgcg aaaaaaacct 13800 gcctccggca tttcccaaca acgggataga gagcctagtg gacaagatga gtagatggaa 13860 gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc ccgcccaccc gtcgtcaaag 13920 gcacgaccgt cagcggggtc tggtgtggga ggacgatgac tcggcagacg acagcagcgt 13980 cctggatttg ggagggagtg gcaacccgtt tgcgcacctt cgccccaggc tggggagaat 14040 gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc accaaggcca tggcaccgag 14100 cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg cgatgtatga ggaaggtcct 14160 cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg cggcggcgct gggttctccc 14220 ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt acctgcggcc taccgggggg 14280 agaaacagca tccgttactc tgagttggca cccctattcg acaccacccg tgtgtacctg 14340 gtggacaaca agtcaacgga tgtggcatcc ctgaactacc agaacgacca cagcaacttt 14400 ctgaccacgg tcattcaaaa caatgactac agcccggggg aggcaagcac acagaccatc 14460 aatcttgacg accggtcgca ctggggcggc gacctgaaaa ccatcctgca taccaacatg 14520 ccaaatgtga acgagttcat gtttaccaat aagtttaagg cgcgggtgat ggtgtcgcgc 14580 ttgcctacta aggacaatca ggtggagctg aaatacgagt gggtggagtt cacgctgccc 14640 gagggcaact actccgagac catgaccata gaccttatga acaacgcgat cgtggagcac 14700 tacttgaaag tgggcagaca gaacggggtt ctggaaagcg acatcggggt aaagtttgac 14760 acccgcaact tcagactggg gtttgacccc gtcactggtc ttgtcatgcc tggggtatat 14820 acaaacgaag ccttccatcc agacatcatt ttgctgccag gatgcggggt ggacttcacc 14880 cacagccgcc tgagcaactt gttgggcatc cgcaagcggc aacccttcca ggagggcttt 14940 aggatcacct acgatgatct ggagggtggt aacattcccg cactgttgga tgtggacgcc 15000 taccaggcga gcttgaaaga tgacaccgaa cagggcgggg gtggcgcagg cggcagcaac 15060 agcagtggca gcggcgcgga agagaactcc aacgcggcag ccgcggcaat gcagccggtg 15120 gaggacatga acgatcatgc cattcgcggc gacacctttg ccacacgggc tgaggagaag 15180 cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg ctgcgcaacc cgaggtcgag 15240 aagcctcaga agaaaccggt gatcaaaccc ctgacagagg acagcaagaa acgcagttac 15300 aacctaataa gcaatgacag caccttcacc cagtaccgca gctggtacct tgcatacaac 15360 tacggcgacc ctcagaccgg aatccgctca tggaccctgc tttgcactcc tgacgtaacc 15420 tgcggctcgg agcaggtcta ctggtcgttg ccagacatga tgcaagaccc cgtgaccttc 15480 cgctccacgc gccagatcag caactttccg gtggtgggcg ccgagctgtt gcccgtgcac 15540 tccaagagct tctacaacga ccaggccgtc tactcccaac tcatccgcca gtttacctct 15600 ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc gccagccccc 15660 accatcacca ccgtcagtga aaacgttcct gctctcacag atcacgggac gctaccgctg 15720 cgcaacagca tcggaggagt ccagcgagtg accattactg acgccagacg ccgcacctgc 15780 ccctacgttt acaaggccct gggcatagtc tcgccgcgcg tcctatcgag ccgcactttt 15840 tgagcaagca tgtccatcct tatatcgccc agcaataaca caggctgggg cctgcgcttc 15900 ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc aacacccagt gcgcgtgcgc 15960 gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc gcactgggcg caccaccgtc 16020 gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact acacgcccac gccgccacca 16080 gtgtccacag tggacgcggc cattcagacc gtggtgcgcg gagcccggcg ctatgctaaa 16140 atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc gccgacccgg cactgccgcc 16200 caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca ccggccgacg ggcggccatg 16260 cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc cccccaggtc caggcgacga 16320 gcggccgccg cagcagccgc ggccattagt gctatgactc agggtcgcag gggcaacgtg 16380 tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg tgcgcacccg ccccccgcgc 16440 aactagattg caagaaaaaa ctacttagac tcgtactgtt gtatgtatcc agcggcggcg 16500 gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag agatgctcca ggtcatcgcg 16560 ccggagatct atggcccccc gaagaaggaa gagcaggatt acaagccccg aaagctaaag 16620 cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg acgacgaggt ggaactgctg 16680 cacgctaccg cgcccaggcg acgggtacag tggaaaggtc gacgcgtaaa acgtgttttg 16740 cgacccggca ccaccgtagt ctttacgccc ggtgagcgct ccacccgcac ctacaagcgc 16800 gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc aggccaacga gcgcctcggg 16860 gagtttgcct acggaaagcg gcataaggac atgctggcgt tgccgctgga cgagggcaac 16920 ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc tgcccgcgct tgcaccgtcc 16980 gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg cacccaccgt gcagctgatg 17040 gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa tgaccgtgga acctgggctg 17100 gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc cgggactggg cgtgcagacc 17160 gtggacgttc agatacccac taccagtagc accagtattg ccaccgccac agagggcatg 17220 gagacacaaa cgtccccggt tgcctcagcg gtggcggatg ccgcggtgca ggcggtcgct 17280 gcggccgcgt ccaagacctc tacggaggtg caaacggacc cgtggatgtt tcgcgtttca 17340 gccccccggc gcccgcgcgg ttcgaggaag tacggcgccg ccagcgcgct actgcccgaa 17400 tatgccctac atccttccat tgcgcctacc cccggctatc gtggctacac ctaccgcccc 17460 agaagacgag caactacccg acgccgaacc accactggaa cccgccgccg ccgtcgccgt 17520 cgccagcccg tgctggcccc gatttccgtg cgcagggtgg ctcgcgaagg aggcaggacc 17580 ctggtgctgc caacagcgcg ctaccacccc agcatcgttt aaaagccggt ctttgtggtt 17640 cttgcagata tggccctcac ctgccgcctc cgtttcccgg tgccgggatt ccgaggaaga 17700 atgcaccgta ggaggggcat ggccggccac ggcctgacgg gcggcatgcg tcgtgcgcac 17760 caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg gtatcctgcc cctccttatt 17820 ccactgatcg ccgcggcgat tggcgccgtg cccggaattg catccgtggc cttgcaggcg 17880 cagagacact gattaaaaac aagttgcatg tggaaaaatc aaaataaaaa gtctggactc 17940 tcacgctcgc ttggtcctgt aactattttg tagaatggaa gacatcaact ttgcgtctct 18000 ggccccgcga cacggctcgc gcccgttcat gggaaactgg caagatatcg gcaccagcaa 18060 tatgagcggt ggcgccttca gctggggctc gctgtggagc ggcattaaaa atttcggttc 18120 caccgttaag aactatggca gcaaggcctg gaacagcagc acaggccaga tgctgaggga 18180 taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat ggcctggcct ctggcattag 18240 cggggtggtg gacctggcca accaggcagt gcaaaataag attaacagta agcttgatcc 18300 ccgccctccc gtagaggagc ctccaccggc cgtggagaca gtgtctccag aggggcgtgg 18360 cgaaaagcgt ccgcgccccg acagggaaga aactctggtg acgcaaatag acgagcctcc 18420 ctcgtacgag gaggcactaa agcaaggcct gcccaccacc cgtcccatcg cgcccatggc 18480 taccggagtg ctgggccagc acacacccgt aacgctggac ctgcctcccc ccgccgacac 18540 ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt gtaacccgtc ctagccgcgc 18600 gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg cccgtagcca gtggcaactg 18660 gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa tccctgaagc gccgacgatg 18720 cttctgaata gctaacgtgt cgtatgtgtg tcatgtatgc gtccatgtcg ccgccagagg 18780 agctgctgag ccgccgcgcg cccgctttcc aagatggcta ccccttcgat gatgccgcag 18840 tggtcttaca tgcacatctc gggccaggac gcctcggagt acctgagccc cgggctggtg 18900 cagtttgccc gcgccaccga gacgtacttc agcctgaata acaagtttag aaaccccacg 18960 gtggcgccta cgcacgacgt gaccacagac cggtcccagc gtttgacgct gcggttcatc 19020 cctgtggacc gtgaggatac tgcgtactcg tacaaggcgc ggttcaccct agctgtgggt 19080 gataaccgtg tgctggacat ggcttccacg tactttgaca tccgcggcgt gctggacagg 19140 ggccctactt ttaagcccta ctctggcact gcctacaacg ccctggctcc caagggtgcc 19200 ccaaatcctt gcgaatggga tgaagctgct actgctcttg aaataaacct agaagaagag 19260 gacgatgaca acgaagacga agtagacgag caagctgagc agcaaaaaac tcacgtattt 19320 gggcaggcgc cttattctgg tataaatatt acaaaggagg gtattcaaat aggtgtcgaa 19380 ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg aacctcaaat aggagaatct 19440 cagtggtacg aaactgaaat taatcatgca gctgggagag tccttaaaaa gactacccca 19500 atgaaaccat gttacggttc atatgcaaaa cccacaaatg aaaatggagg gcaaggcatt 19560 cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg aaatgcaatt tttctcaact 19620 actgaggcga ccgcaggcaa tggtgataac ttgactccta aagtggtatt gtacagtgaa 19680 gatgtagata tagaaacccc agacactcat atttcttaca tgcccactat taaggaaggt 19740 aactcacgag aactaatggg ccaacaatct atgcccaaca ggcctaatta cattgctttt 19800 agggacaatt ttattggtct aatgtattac aacagcacgg gtaatatggg tgttctggcg 19860 ggccaagcat cgcagttgaa tgctgttgta gatttgcaag acagaaacac agagctttca 19920 taccagcttt tgcttgattc cattggtgat agaaccaggt acttttctat gtggaatcag 19980 gctgttgaca gctatgatcc agatgttaga attattgaaa atcatggaac tgaagatgaa 20040 cttccaaatt actgctttcc actgggaggt gtgattaata cagagactct taccaaggta 20100 aaacctaaaa caggtcagga aaatggatgg gaaaaagatg ctacagaatt ttcagataaa 20160 aatgaaataa gagttggaaa taattttgcc atggaaatca atctaaatgc caacctgtgg 20220 agaaatttcc tgtactccaa catagcgctg tatttgcccg acaagctaaa gtacagtcct 20280 tccaacgtaa aaatttctga taacccaaac acctacgact acatgaacaa gcgagtggtg 20340 gctcccgggt tagtggactg ctacattaac cttggagcac gctggtccct tgactatatg 20400 gacaacgtca acccatttaa ccaccaccgc aatgctggcc tgcgctaccg ctcaatgttg 20460 ctgggcaatg gtcgctatgt gcccttccac atccaggtgc ctcagaagtt ctttgccatt 20520 aaaaacctcc ttctcctgcc gggctcatac acctacgagt ggaacttcag gaaggatgtt 20580 aacatggttc tgcagagctc cctaggaaat gacctaaggg ttgacggagc cagcattaag 20640 tttgatagca tttgccttta cgccaccttc ttccccatgg cccacaacac cgcctccacg 20700 cttgaggcca tgcttagaaa cgacaccaac gaccagtcct ttaacgacta tctctccgcc 20760 gccaacatgc tctaccctat acccgccaac gctaccaacg tgcccatatc catcccctcc 20820 cgcaactggg cggctttccg cggctgggcc ttcacgcgcc ttaagactaa ggaaacccca 20880 tcactgggct cgggctacga cccttattac acctactctg gctctatacc ctacctagat 20940 ggaacctttt acctcaacca cacctttaag aaggtggcca ttacctttga ctcttctgtc 21000 agctggcctg gcaatgaccg cctgcttacc cccaacgagt ttgaaattaa gcgctcagtt 21060 gacggggagg gttacaacgt tgcccagtgt aacatgacca aagactggtt cctggtacaa 21120 atgctagcta actacaacat tggctaccag ggcttctata tcccagagag ctacaaggac 21180 cgcatgtact ccttctttag aaacttccag cccatgagcc gtcaggtggt ggatgatact 21240 aaatacaagg actaccaaca ggtgggcatc ctacaccaac acaacaactc tggatttgtt 21300 ggctaccttg cccccaccat gcgcgaagga caggcctacc ctgctaactt cccctatccg 21360 cttataggca agaccgcagt tgacagcatt acccagaaaa agtttctttg cgatcgcacc 21420 ctttggcgca tcccattctc cagtaacttt atgtccatgg gcgcactcac agacctgggc 21480 caaaaccttc tctacgccaa ctccgcccac gcgctagaca tgacttttga ggtggatccc 21540 atggacgagc ccacccttct ttatgttttg tttgaagtct ttgacgtggt ccgtgtgcac 21600 cggccgcacc gcggcgtcat cgaaaccgtg tacctgcgca cgcccttctc ggccggcaac 21660 gccacaacat aaagaagcaa gcaacatcaa caacagctgc cgccatgggc tccagtgagc 21720 aggaactgaa agccattgtc aaagatcttg gttgtgggcc atattttttg ggcacctatg 21780 acaagcgctt tccaggcttt gtttctccac acaagctcgc ctgcgccata gtcaatacgg 21840 ccggtcgcga gactgggggc gtacactgga tggcctttgc ctggaacccg cactcaaaaa 21900 catgctacct ctttgagccc tttggctttt ctgaccagcg actcaagcag gtttaccagt 21960 ttgagtacga gtcactcctg cgccgtagcg ccattgcttc ttcccccgac cgctgtataa 22020 cgctggaaaa gtccacccaa agcgtacagg ggcccaactc ggccgcctgt ggactattct 22080 gctgcatgtt tctccacgcc tttgccaact ggccccaaac tcccatggat cacaacccca 22140 ccatgaacct tattaccggg gtacccaact ccatgctcaa cagtccccag gtacagccca 22200 ccctgcgtcg caaccaggaa cagctctaca gcttcctgga gcgccactcg ccctacttcc 22260 gcagccacag tgcgcagatt aggagcgcca cttctttttg tcacttgaaa aacatgtaaa 22320 aataatgtac tagagacact ttcaataaag gcaaatgctt ttatttgtac actctcgggt 22380 gattatttac ccccaccctt gccgtctgcg ccgtttaaaa atcaaagggg ttctgccgcg 22440 catcgctatg cgccactggc agggacacgt tgcgatactg gtgtttagtg ctccacttaa 22500 actcaggcac aaccatccgc ggcagctcgg tgaagttttc actccacagg ctgcgcacca 22560 tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa gtcgcagttg gggcctccgc 22620 cctgcgcgcg cgagttgcga tacacagggt tgcagcactg gaacactatc agcgccgggt 22680 ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc cgcgtccagg tcctccgcgt 22740 tgctcagggc gaacggagtc aactttggta gctgccttcc caaaaagggc gcgtgcccag 22800 gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg accgtgcccg gtctgggcgt 22860 taggatacag cgcctgcata aaagccttga tctgcttaaa agccacctga gcctttgcgc 22920 cttcagagaa gaacatgccg caagacttgc cggaaaactg attggccgga caggccgcgt 22980 cgtgcacgca gcaccttgcg tcggtgttgg agatctgcac cacatttcgg ccccaccggt 23040 tcttcacgat cttggccttg ctagactgct ccttcagcgc gcgctgcccg ttttcgctcg 23100 tcacatccat ttcaatcacg tgctccttat ttatcataat gcttccgtgt agacacttaa 23160 gctcgccttc gatctcagcg cagcggtgca gccacaacgc gcagcccgtg ggctcgtgat 23220 gcttgtaggt cacctctgca aacgactgca ggtacgcctg caggaatcgc cccatcatcg 23280 tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc gcggtgctcc tcgttcagcc 23340 aggtcttgca tacggccgcc agagcttcca cttggtcagg cagtagtttg aagttcgcct 23400 ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg cgcagcctcc atgcccttct 23460 cccacgcaga cacgatcggc acactcagcg ggttcatcac cgtaatttca ctttccgctt 23520 cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg cgccactggg tcgtcttcat 23580 tcagccgccg cactgtgcgc ttacctcctt tgccatgctt gattagcacc ggtgggttgc 23640 tgaaacccac catttgtagc gccacatctt ctctttcttc ctcgctgtcc acgattacct 23700 ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt ctttttcttc ttgggcgcaa 23760 tggccaaatc cgccgccgag gtcgatggcc gcgggctggg tgtgcgcggc accagcgcgt 23820 cttgtgatga gtcttcctcg tcctcggact cgatacgccg cctcatccgc ttttttgggg 23880 gcgcccgggg aggcggcggc gacggggacg gggacgacac gtcctccatg gttgggggac 23940 gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg ctgctcctct tcccgactgg 24000 ccatttcctt ctcctatagg cagaaaaaga tcatggagtc agtcgagaag aaggacagcc 24060 taaccgcccc ctctgagttc gccaccaccg cctccaccga tgccgccaac gcgcctacca 24120 ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt gattatcgag caggacccag 24180 gttttgtaag cgaagacgac gaggaccgct cagtaccaac agaggataaa aagcaagacc 24240 aggacaacgc agaggcaaac gaggaacaag tcgggcgggg ggacgaaagg catggcgact 24300 acctagatgt gggagacgac gtgctgttga agcatctgca gcgccagtgc gccattatct 24360 gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat agcggatgtc agccttgcct 24420 acgaacgcca cctattctca ccgcgcgtac cccccaaacg ccaagaaaac ggcacatgcg 24480 agcccaaccc gcgcctcaac ttctaccccg tatttgccgt gccagaggtg cttgccacct 24540 atcacatctt tttccaaaac tgcaagatac ccctatcctg ccgtgccaac cgcagccgag 24600 cggacaagca gctggccttg cggcagggcg ctgtcatacc tgatatcgcc tcgctcaacg 24660 aagtgccaaa aatctttgag ggtcttggac gcgacgagaa gcgcgcggca aacgctctgc 24720 aacaggaaaa cagcgaaaat gaaagtcact ctggagtgtt ggtggaactc gagggtgaca 24780 acgcgcgcct agccgtacta aaacgcagca tcgaggtcac ccactttgcc tacccggcac 24840 ttaacctacc ccccaaggtc atgagcacag tcatgagtga gctgatcgtg cgccgtgcgc 24900 agcccctgga gagggatgca aatttgcaag aacaaacaga ggagggccta cccgcagttg 24960 gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc tgccgacttg gaggagcgac 25020 gcaaactaat gatggccgca gtgctcgtta ccgtggagct tgagtgcatg cagcggttct 25080 ttgctgaccc ggagatgcag cgcaagctag aggaaacatt gcactacacc tttcgacagg 25140 gctacgtacg ccaggcctgc aagatctcca acgtggagct ctgcaacctg gtctcctacc 25200 ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct tcattccacg ctcaagggcg 25260 aggcgcgccg cgactacgtc cgcgactgcg tttacttatt tctatgctac acctggcaga 25320 cggccatggg cgtttggcag cagtgcttgg aggagtgcaa cctcaaggag ctgcagaaac 25380 tgctaaagca aaacttgaag gacctatgga cggccttcaa cgagcgctcc gtggccgcgc 25440 acctggcgga catcattttc cccgaacgcc tgcttaaaac cctgcaacag ggtctgccag 25500 acttcaccag tcaaagcatg ttgcagaact ttaggaactt tatcctagag cgctcaggaa 25560 tcttgcccgc cacctgctgt gcacttccta gcgactttgt gcccattaag taccgcgaat 25620 gccctccgcc gctttggggc cactgctacc ttctgcagct agccaactac cttgcctacc 25680 actctgacat aatggaagac gtgagcggtg acggtctact ggagtgtcac tgtcgctgca 25740 acctatgcac cccgcaccgc tccctggttt gcaattcgca gctgcttaac gaaagtcaaa 25800 ttatcggtac ctttgagctg cagggtccct cgcctgacga aaagtccgcg gctccggggt 25860 tgaaactcac tccggggctg tggacgtcgg cttaccttcg caaatttgta cctgaggact 25920 accacgccca cgagattagg ttctacgaag accaatcccg cccgccaaat gcggagctta 25980 ccgcctgcgt cattacccag ggccacattc ttggccaatt gcaagccatc aacaaagccc 26040 gccaagagtt tctgctacga aagggacggg gggtttactt ggacccccag tccggcgagg 26100 agctcaaccc aatccccccg ccgccgcagc cctatcagca gcagccgcgg gcccttgctt 26160 cccaggatgg cacccaaaaa gaagctgcag ctgccgccgc cacccacgga cgaggaggaa 26220 tactgggaca gtcaggcaga ggaggttttg gacgaggagg aggaggacat gatggaagac 26280 tgggagagcc tagacgagga agcttccgag gtcgaagagg tgtcagacga aacaccgtca 26340 ccctcggtcg cattcccctc gccggcgccc cagaaatcgg caaccggttc cagcatggct 26400 acaacctccg ctcctcaggc gccgccggca ctgcccgttc gccgacccaa ccgtagatgg 26460 gacaccactg gaaccagggc cggtaagtcc aagcagccgc cgccgttagc ccaagagcaa 26520 caacagcgcc aaggctaccg ctcatggcgc gggcacaaga acgccatagt tgcttgcttg 26580 caagactgtg ggggcaacat ctccttcgcc cgccgctttc ttctctacca tcacggcgtg 26640 gccttccccc gtaacatcct gcattactac cgtcatctct acagcccata ctgcaccggc 26700 ggcagcggca gcggcagcaa cagcagcggc cacacagaag caaaggcgac cggatagcaa 26760 gactctgaca aagcccaaga aatccacagc ggcggcagca gcaggaggag gagcgctgcg 26820 tctggcgccc aacgaacccg tatcgacccg cgagcttaga aacaggattt ttcccactct 26880 gtatgctata tttcaacaga gcaggggcca agaacaagag ctgaaaataa aaaacaggtc 26940 tctgcgatcc ctcacccgca gctgcctgta tcacaaaagc gaagatcagc ttcggcgcac 27000 gctggaagac gcggaggctc tcttcagtaa atactgcgcg ctgactctta aggactagtt 27060 tcgcgccctt tctcaaattt aagcgcgaaa actacgtcat ctccagcggc cacacccggc 27120 gccagcacct gtcgtcagcg ccatttatga gcaaggaaat tcccacgccc tacatgtgga 27180 gttaccagcc acaaatggga cttgcggctg gagctgccca agactactca acccgaataa 27240 actacatgag cgcgggaccc cacatgatat cccgggtcaa cggaatacgc gcccaccgaa 27300 accgaattct cctggaacag gcggctatta ccaccacacc tcgtaataac cttaatcccc 27360 gtagttggcc cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc 27420 ccagagacgc ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct 27480 ttcgtcacag ggtgcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag 27540 gtattcagct caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat 27600 ttcagatcgg cggcgccggc cgctcttcat tcacgcctcg tcaggcaatc ctaactctgc 27660 agacctcgtc ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt 27720 ttgtgccatc ggtctacttt aaccccttct cgggacctcc cggccactat ccggatcaat 27780 ttattcctaa ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg 27840 gagaggcaga gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg 27900 cccgcgactc cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg 27960 cgcacggcgt ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta 28020 cccagcgccc cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca 28080 actgtcctaa ccctggatta catcaagatc tttgttgcca tctctgtgct gagtataata 28140 aatacagaaa ttaaaatata ctggggctcc tatcgccatc ctgtaaacgc caccgtcttc 28200 acccgcccaa gcaaaccaag gcgaacctta cctggtactt ttaacatctc tccctctgtg 28260 atttacaaca gtttcaaccc agacggagtg agtctacgag agaacctctc cgagctcagc 28320 tactccatca gaaaaaacac caccctcctt acctgccggg aacgtacgag tgcgtcaccg 28380 gccgctgcac cacacctacc gcctgaccgt aaaccagact ttttccggac agacctcaat 28440 aactctgttt accagaacag gaggtgagct tagaaaaccc ttagggtatt aggccaaagg 28500 cgcagctact gtggggttta tgaacaattc aagcaactct acgggctatt ctaattcagg 28560 tttctctaga atcggggttg gggttattct ctgtcttgtg attctcttta ttcttatact 28620 aacgcttctc tgcctaaggc tcgccgcctg ctgtgtgcac atttgcattt attgtcagct 28680 ttttaaacgc tggggtcgcc acccaagatg attaggtaca taatcctagg tttactcacc 28740 cttgcgtcag cccacggtac cacccaaaag gtggatttta aggagccagc ctgtaatgtt 28800 acattcgcag ctgaagctaa tgagtgcacc actcttataa aatgcaccac agaacatgaa 28860 aagctgctta ttcgccacaa aaacaaaatt ggcaagtatg ctgtttatgc tatttggcag 28920 ccaggtgaca ctacagagta taatgttaca gttttccagg gtaaaagtca taaaactttt 28980 atgtatactt ttccatttta tgaaatgtgc gacattacca tgtacatgag caaacagtat 29040 aagttgtggc ccccacaaaa ttgtgtggaa aacactggca ctttctgctg cactgctatg 29100 ctaattacag tgctcgcttt ggtctgtacc ctactctata ttaaatacaa aagcagacgc 29160 agctttattg aggaaaagaa aatgccttaa tttactaagt tacaaagcta atgtcaccac 29220 taactgcttt actcgctgct tgcaaaacaa attcaaaaag ttagcattat aattagaata 29280 ggatttaaac cccccggtca tttcctgctc aataccattc ccctgaacaa ttgactctat 29340 gtgggatatg ctccagcgct acaaccttga agtcaggctt cctggatgtc agcatctgac 29400 tttggccagc acctgtcccg cggatttgtt ccagtccaac tacagcgacc caccctaaca 29460 gagatgacca acacaaccaa cgcggccgcc gctaccggac ttacatctac cacaaataca 29520 ccccaagttt ctgcctttgt caataactgg gataacttgg gcatgtggtg gttctccata 29580 gcgcttatgt ttgtatgcct tattattatg tggctcatct gctgcctaaa gcgcaaacgc 29640 gcccgaccac ccatctatag tcccatcatt gtgctacacc caaacaatga tggaatccat 29700 agattggacg gactgaaaca catgttcttt tctcttacag tatgattaaa tgagacatga 29760 ttcctcgagt ttttatatta ctgacccttg ttgcgctttt ttgtgcgtgc tccacattgg 29820 ctgcggtttc tcacatcgaa gtagactgca ttccagcctt cacagtctat ttgctttacg 29880 gatttgtcac cctcacgctc atctgcagcc tcatcactgt ggtcatcgcc tttatccagt 29940 gcattgactg ggtctgtgtg cgctttgcat atctcagaca ccatccccag tacagggaca 30000 ggactatagc tgagcttctt agaattcttt aattatgaaa tttactgtga cttttctgct 30060 gattatttgc accctatctg cgttttgttc cccgacctcc aagcctcaaa gacatatatc 30120 atgcagattc actcgtatat ggaatattcc aagttgctac aatgaaaaaa gcgatctttc 30180 cgaagcctgg ttatatgcaa tcatctctgt tatggtgttc tgcagtacca tcttagccct 30240 agctatatat ccctaccttg acattggctg gaacgcaata gatgccatga accacccaac 30300 tttccccgcg cccgctatgc ttccactgca acaagttgtt gccggcggct ttgtcccagc 30360 caatcagcct cgcccacctt ctcccacccc cactgaaatc agctacttta atctaacagg 30420 aggagatgac tgacacccta gatctagaaa tggacggaat tattacagag cagcgcctgc 30480 tagaaagacg cagggcagcg gccgagcaac agcgcatgaa tcaagagctc caagacatgg 30540 ttaacttgca ccagtgcaaa aggggtatct tttgtctggt aaagcaggcc aaagtcacct 30600 acgacagtaa taccaccgga caccgcctta gctacaagtt gccaaccaag cgtcagaaat 30660 tggtggtcat ggtgggagaa aagcccatta ccataactca gcactcggta gaaaccgaag 30720 gctgcattca ctcaccttgt caaggacctg aggatctctg cacccttatt aagaccctgt 30780 gcggtctcaa agatcttatt ccctttaact aataaaaaaa aataataaag catcacttac 30840 ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc 30900 cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg 30960 tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag 31020 cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt 31080 cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt 31140 ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt 31200 gcgctcaaaa tgggcaacgg cctctctctg gacgaggccg gcaaccttac ctcccaaaat 31260 gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct 31320 gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc 31380 gcgggcaaca cactcaccat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt 31440 agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca 31500 ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact 31560 actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa 31620 ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac tttgaccgta 31680 gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc 31740 ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat 31800 tctcaaaaca gacgccttat acttgatgtt agttatccgt ttgatgctca aaaccaacta 31860 aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac 31920 tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac 31980 ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat 32040 gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc 32100 catggcctag aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt 32160 tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg 32220 accacaccag ctccatctcc taactgtaga ctaaatgcag agaaagatgc taaactcact 32280 ttggtcttaa caaaatgtgg cagtcaaata cttgctacag tttcagtttt ggctgttaaa 32340 ggcagtttgg ctccaatatc tggaacagtt caaagtgctc atcttattat aagatttgac 32400 gaaaatggag tgctactaaa caattccttc ctggacccag aatattggaa ctttagaaat 32460 ggagatctta ctgaaggcac agcctataca aacgctgttg gatttatgcc taacctatca 32520 gcttatccaa aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca agtttactta 32580 aacggagaca aaactaaacc tgtaacacta accattacac taaacggtac acaggaaaca 32640 ggagacacaa ctccaagtgc atactctatg tcattttcat gggactggtc tggccacaac 32700 tacattaatg aaatatttgc cacatcctct tacacttttt catacattgc ccaagaataa 32760 agaatcgttt gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcgaatca 32820 tttttcattc agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa 32880 tcaaacctac atgggggtag agtcataatc gtgcatcagg atagggcggt ggtgctgcag 32940 cagcgcgcga ataaactgct gccgccgccg ctccgtcctg caggaataca acatggcagt 33000 ggtctcctca gcgatgattc gcaccgcccg cagcataagg cgccttgtcc tccgggcaca 33060 gcagcgcacc ctgatctcac ttaaatcagc acagtaactg cagcacagca ccacaatatt 33120 gttcaaaatc ccacagtgca aggcgctgta tccaaagctc atggcgggga ccacagaacc 33180 cacgtggcca tcataccaca agcgcaggta gattaagtgg cgacccctca taaacacgct 33240 ggacataaac attacctctt ttggcatgtt gtaattcacc acctcccggt accatataaa 33300 cctctgatta aacatggcgc catccaccac catcctaaac cagctggcca aaacctgccc 33360 gccggctata cactgcaggg aaccgggact ggaacaatga cagtggagag cccaggactc 33420 gtaaccatgg atcatcatgc tcgtcatgat atcaatgttg gcacaacaca ggcacacgtg 33480 catacacttc ctcaggatta caagctcctc ccgcgttaga accatatccc agggaacaac 33540 ccattcctga atcagcgtaa atcccacact gcagggaaga cctcgcacgt aactcacgtt 33600 gtgcattgtc aaagtgttac attcgggcag cagcggatga tcctccagta tggtagcgcg 33660 ggtttctgtc tcaaaaggag gtagacgatc cctactgtac ggagtgcgcc gagacaaccg 33720 agatcgtgtt ggtcgtagtg tcatgccaaa tggaacgccg gacgtagtca tatttcctga 33780 agcaaaacca ggtgcgggcg tgacaaacag atctgcgtct ccggtctcgc cgcttagatc 33840 gctctgtgta gtagttgtag tatatccact ctctcaaagc atccaggcgc cccctggctt 33900 cgggttctat gtaaactcct tcatgcgccg ctgccctgat aacatccacc accgcagaat 33960 aagccacacc cagccaacct acacattcgt tctgcgagtc acacacggga ggagcgggaa 34020 gagctggaag aaccatgttt ttttttttat tccaaaagat tatccaaaac ctcaaaatga 34080 agatctatta agtgaacgcg ctcccctccg gtggcgtggt caaactctac agccaaagaa 34140 cagataatgg catttgtaag atgttgcaca atggcttcca aaaggcaaac ggccctcacg 34200 tccaagtgga cgtaaaggct aaacccttca gggtgaatct cctctataaa cattccagca 34260 ccttcaacca tgcccaaata attctcatct cgccaccttc tcaatatatc tctaagcaaa 34320 tcccgaatat taagtccggc cattgtaaaa atctgctcca gagcgccctc caccttcagc 34380 ctcaagcagc gaatcatgat tgcaaaaatt caggttcctc acagacctgt ataagattca 34440 aaagcggaac attaacaaaa ataccgcgat cccgtaggtc ccttcgcagg gccagctgaa 34500 cataatcgtg caggtctgca cggaccagcg cggccacttc cccgccagga accatgacaa 34560 aagaacccac actgattatg acacgcatac tcggagctat gctaaccagc gtagccccga 34620 tgtaagcttg ttgcatgggc ggcgatataa aatgcaaggt gctgctcaaa aaatcaggca 34680 aagcctcgcg caaaaaagaa agcacatcgt agtcatgctc atgcagataa aggcaggtaa 34740 gctccggaac caccacagaa aaagacacca tttttctctc aaacatgtct gcgggtttct 34800 gcataaacac aaaataaaat aacaaaaaaa catttaaaca ttagaagcct gtcttacaac 34860 aggaaaaaca acccttataa gcataagacg gactacggcc atgccggcgt gaccgtaaaa 34920 aaactggtca ccgtgattaa aaagcaccac cgacagctcc tcggtcatgt ccggagtcat 34980 aatgtaagac tcggtaaaca catcaggttg attcacatcg gtcagtgcta aaaagcgacc 35040 gaaatagccc gggggaatac atacccgcag gcgtagagac aacattacag cccccatagg 35100 aggtataaca aaattaatag gagagaaaaa cacataaaca cctgaaaaac cctcctgcct 35160 aggcaaaata gcaccctccc gctccagaac aacatacagc gcttccacag cggcagccat 35220 aacagtcagc cttaccagta aaaaagaaaa cctattaaaa aaacaccact cgacacggca 35280 ccagctcaat cagtcacagt gtaaaaaagg gccaagtgca gagcgagtat atataggact 35340 aaaaaatgac gtaacggtta aagtccacaa aaaacaccca gaaaaccgca cgcgaaccta 35400 cgcccagaaa cgaaagccaa aaaacccaca acttcctcaa atcgtcactt ccgttttccc 35460 acgttacgtc acttcccatt ttaagaaaac tacaattccc aacacataca agttactccg 35520 ccctaaaacc tacgtcaccc gccccgttcc cacgccccgc gccacgtcac aaactccacc 35580 ccctcattat catattggct tcaatccaaa ataaggtata ttattgatga tg 35632 <210> 23 <211> 35623 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO297) <400> 23 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgaccgaaga aatggccgcc agtcttttgg accagctgat 600 cgaagaggta ctggctgata atcttccacc tcctagccat tttgaaccac ctacccttca 660 cgaactgcat gatttagacg tgacggcccc cgaagatccc aacgaggagg cggtttcgca 720 gatttttccc gactctgtaa tgttggcggt gcaggaaggg attgacttac tcacttttcc 780 gccggcgccc ggttctccgg agccgcctca cctttcccgg cagcccgagc agccggagca 840 gagagccttg ggtccggttt ctatgccaaa ccttgtaccg gaggtgatcg atcttaccgg 900 ccacgaggct ggctttccac ccagtgacga cgaggatgaa gagggtgagg agtttgtgtt 960 agattatgtg gagcaccccg ggcacggttg caggtcttgt cattatcacc ggaggaatac 1020 gggggaccca gatattatgt gttcgctttg ctatatgagg acctgtggca tgtttgtcta 1080 cagtaagtga aaattatggg cagtgggtga tagagtggtg ggtttggtgt ggtaattttt 1140 tttttaattt ttacagtttt gtggtttaaa gaattttgta ttgtgatttt tttaaaaggt 1200 cctgtgtctg aacctgagcc tgagcccgag ccagaaccgg agcctgcaag acctacccgc 1260 cgtcctaaaa tggcgcctgc tatcctgaga cgcccgacat cacctgtgtc tagagaatgc 1320 aatagtagta cggatagctg tgactccggt ccttctaaca cacctcctga gatacacccg 1380 gtggtcccgc tgtgccccat taaaccagtt gccgtgagag ttggtgggcg tcgccaggct 1440 gtggaatgta tcgaggactt gcttaacgag cctgggcaac ctttggactt gagctgtaaa 1500 cgccccaggc cataaggtgt aaacctgtga ttgcgtgtgt ggttaacgcc tttgtttgct 1560 gaatgagttg atgtaagttt aataaagggt gagataatgt ttaacttgca tggcgtgtta 1620 aatggggcgg ggcttaaagg gtatataatg cgccgtgggc taatcttggt tacatctgac 1680 ctcatggagg cttgggagtg tttggaagat ttttctgctg tgcgtaactt gctggaacag 1740 agctctaaca gtacctcttg gttttggagg tttctgtggg gctcatccca ggcaaagtta 1800 gtctgcagaa ttaaggagga ttacaagtgg gaatttgaag agcttttgaa atcctgtggt 1860 gagctgtttg attctttgaa tctgggtcac caggcgcttt tccaagagaa ggtcatcaag 1920 actttggatt tttccacacc ggggcgcgct gcggctgctg ttgctttttt gagttttata 1980 aaggataaat ggagcgaaga aacccatctg agcggggggt acctgctgga ttttctggcc 2040 atgcatctgt ggagagcggt tgtgagacac aagaatcgcc tgctactgtt gtcttccgtc 2100 cgcccggcga taataccgac ggaggagcag cagcagcagc aggaggaagc caggcggcgg 2160 cggcaggagc agagcccatg gaacccgaga gccggcctgg accctcggga atgaatgttg 2220 tacaggtggc tgaactgtat ccagaactga gacgcatttt gacaattaca gaggatgggc 2280 aggggctaaa gggggtaaag agggagcggg gggcttgtga ggctacagag gaggctagga 2340 atctagcttt tagcttaatg accagacacc gtcctgagtg tattactttt caacagatca 2400 aggataattg cgctaatgag cttgatctgc tggcgcagaa gtattccata gagcagctga 2460 ccacttactg gctgcagcca ggggatgatt ttgaggaggc tattagggta tatgcaaagg 2520 tggcacttag gccagattgc aagtacaaga tcagcaaact tgtaaatatc aggaattgtt 2580 gctacatttc tgggaacggg gccgaggtgg agatagatac ggaggatagg gtggccttta 2640 gatgtagcat gataaatatg tggccggggg tgcttggcat ggacggggtg gttattatga 2700 atgtaaggtt tactggcccc aattttagcg gtacggtttt cctggccaat accaacctta 2760 tcctacacgg tgtaagcttc tatgggttta acaatacctg tgtggaagcc tggaccgatg 2820 taagggttcg gggctgtgcc ttttactgct gctggaaggg ggtggtgtgt cgccccaaaa 2880 gcagggcttc aattaagaaa tgcctctttg aaaggtgtac cttgggtatc ctgtctgagg 2940 gtaactccag ggtgcgccac aatgtggcct ccgactgtgg ttgcttcatg ctagtgaaaa 3000 gcgtggctgt gattaagcat aacatggtat gtggcaactg cgaggacagg gcctctcaga 3060 tgctgacctg ctcggacggc aactgtcacc tgctgaagac cattcacgta gccagccact 3120 ctcgcaaggc ctggccagtg tttgagcata acatactgac ccgctgttcc ttgcatttgg 3180 gtaacaggag gggggtgttc ctaccttacc aatgcaattt gagtcacact aagatattgc 3240 ttgagcccga gagcatgtcc aaggtgaacc tgaacggggt gtttgacatg accatgaaga 3300 tctggaaggt gctgaggtac gatgagaccc gcaccaggtg cagaccctgc gagtgtggcg 3360 gtaaacatat taggaaccag cctgtgatgc tggatgtgac cgaggagctg aggcccgatc 3420 acttggtgct ggcctgcacc cgcgctgagt ttggctctag cgatgaagat acagattgag 3480 gtactgaaat gtgtgggcgt ggcttaaggg tgggaaagaa tatataaggt gggggtctta 3540 tgtagttttg tatctgtttt gcagcagccg ccgccgccat gagcaccaac tcgtttgatg 3600 gaagcattgt gagctcatat ttgacaacgc gcatgccccc atgggccggg gtgcgtcaga 3660 atgtgatggg ctccagcatt gatggtcgcc ccgtcctgcc cgcaaactct actaccttga 3720 cctacgagac cgtgtctgga acgccgttgg agactgcagc ctccgccgcc gcttcagccg 3780 ctgcagccac cgcccgcggg attgtgactg actttgcttt cctgagcccg cttgcaagca 3840 gtgcagcttc ccgttcatcc gcccgcgatg acaagttgac ggctcttttg gcacaattgg 3900 attctttgac ccgggaactt aatgtcgttt ctcagcagct gttggatctg cgccagcagg 3960 tttctgccct gaaggcttcc tcccctccca atgcggttta aaacataaat aaaaaaccag 4020 actctgtttg gatttggatc aagcataagt gtcttgctgt ctttatttag gggttttgcg 4080 cgcgcggtag gcccgggacc agcggtctcg gtcgttgagg gtcctgtgta ttttttccag 4140 gacgtggtaa aggtgactct ggatgttcag atacatgggc ataagcccgt ctctggggtg 4200 gaggtagcac cactgcagag cttcatgctg cggggtggtg ttgtagatga tccagtcgta 4260 gcaggagcgc tgggcgtggt gcctaaaaat gtctttcagt agcaagctga ttgccagggg 4320 caggcccttg gtgtaagtgt ttacaaagcg gttaagctgg gatgggtgca tacgtgggga 4380 tatgagatgc atcttggact gtatttttag gttggctatg ttcccagcca tatccctccg 4440 gggattcatg ttgtgcagaa ccaccagcac agtgtatccg gtgcacttgg gaaatttgtc 4500 atgtagctta gaaggaaatg cgtggaagaa cttggagacg cccttgtgac ctccaagatt 4560 ttccatgcat tcgtccataa tgatggcaat gggcccacgg gcggcggcct gggcgaagat 4620 atttctggga tcactaacgt catagttgtg ttccaggatg agatcgtcat aggccatttt 4680 tacaaagcgc gggcggaggg tgccagactg cggtataatg gttccatccg gcccaggggc 4740 gtagttaccc tcacagattt gcatttccca cgctttgagt tcagatgggg ggatcatgtc 4800 tacctgcggg gcgatgaaga aaacggtttc cggggtaggg gagatcagct gggaagaaag 4860 caggttcctg agcagctgcg acttaccgca gccggtgggc ccgtaaatca cacctattac 4920 cgggtgcaac tggtagttaa gagagctgca gctgccgtca tccctgagca ggggggccac 4980 ttcgttaagc atgtccctga ctcgcatgtt ttccctgacc aaatccgcca gaaggcgctc 5040 gccgcccagc gatagcagtt cttgcaagga agcaaagttt ttcaacggtt tgagaccgtc 5100 cgccgtaggc atgcttttga gcgtttgacc aagcagttcc aggcggtccc acagctcggt 5160 cacctgctct acggcatctc gatccagcat atctcctcgt ttcgcgggtt ggggcggctt 5220 tcgctgtacg gcagtagtcg gtgctcgtcc agacgggcca gggtcatgtc tttccacggg 5280 cgcagggtcc tcgtcagcgt agtctgggtc acggtgaagg ggtgcgctcc gggctgcgcg 5340 ctggccaggg tgcgcttgag gctggtcctg ctggtgctga agcgctgccg gtcttcgccc 5400 tgcgcgtcgg ccaggtagca tttgaccatg gtgtcatagt ccagcccctc cgcggcgtgg 5460 cccttggcgc gcagcttgcc cttggaggag gcgccgcacg aggggcagtg cagacttttg 5520 agggcgtaga gcttgggcgc gagaaatacc gattccgggg agtaggcatc cgcgccgcag 5580 gccccgcaga cggtctcgca ttccacgagc caggtgagct ctggccgttc ggggtcaaaa 5640 accaggtttc ccccatgctt tttgatgcgt ttcttacctc tggtttccat gagccggtgt 5700 ccacgctcgg tgacgaaaag gctgtccgtg tccccgtata cagacttgag aggcctgtcc 5760 tcgagcggtg ttccgcggtc ctcctcgtat agaaactcgg accactctga gacaaaggct 5820 cgcgtccagg ccagcacgaa ggaggctaag tgggaggggt agcggtcgtt gtccactagg 5880 gggtccactc gctccagggt gtgaagacac atgtcgccct cttcggcatc aaggaaggtg 5940 attggtttgt aggtgtaggc cacgtgaccg ggtgttcctg aaggggggct ataaaagggg 6000 gtgggggcgc gttcgtcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg 6060 ggtgagtact ccctctgaaa agcgggcatg acttctgcgc taagattgtc agtttccaaa 6120 aacgaggagg atttgatatt cacctggccc gcggtgatgc ctttgagggt ggccgcatcc 6180 atctggtcag aaaagacaat ctttttgttg tcaagcttgg tggcaaacga cccgtagagg 6240 gcgttggaca gcaacttggc gatggagcgc agggtttggt ttttgtcgcg atcggcgcgc 6300 tccttggccg cgatgtttag ctgcacgtat tcgcgcgcaa cgcaccgcca ttcgggaaag 6360 acggtggtgc gctcgtcggg caccaggtgc acgcgccaac cgcggttgtg cagggtgaca 6420 aggtcaacgc tggtggctac ctctccgcgt aggcgctcgt tggtccagca gaggcggccg 6480 cccttgcgcg agcagaatgg cggtaggggg tctagctgcg tctcgtccgg ggggtctgcg 6540 tccacggtaa agaccccggg cagcaggcgc gcgtcgaagt agtctatctt gcatccttgc 6600 aagtctagcg cctgctgcca tgcgcgggcg gcaagcgcgc gctcgtatgg gttgagtggg 6660 ggaccccatg gcatggggtg ggtgagcgcg gaggcgtaca tgccgcaaat gtcgtaaacg 6720 tagaggggct ctctgagtat tccaagatat gtagggtagc atcttccacc gcggatgctg 6780 gcgcgcacgt aatcgtatag ttcgtgcgag ggagcgagga ggtcgggacc gaggttgcta 6840 cgggcgggct gctctgctcg gaagactatc tgcctgaaga tggcatgtga gttggatgat 6900 atggttggac gctggaagac gttgaagctg gcgtctgtga gacctaccgc gtcacgcacg 6960 aaggaggcgt aggagtcgcg cagcttgttg accagctcgg cggtgacctg cacgtctagg 7020 gcgcagtagt ccagggtttc cttgatgatg tcatacttat cctgtccctt ttttttccac 7080 agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt actcttggat cggaaacccg 7140 tcggcctccg aacggtaaga gcctagcatg tagaactggt tgacggcctg gtaggcgcag 7200 catccctttt ctacgggtag cgcgtatgcc tgcgcggcct tccggagcga ggtgtgggtg 7260 agcgcaaagg tgtccctgac catgactttg aggtactggt atttgaagtc agtgtcgtcg 7320 catccgccct gctcccagag caaaaagtcc gtgcgctttt tggaacgcgg atttggcagg 7380 gcgaaggtga catcgttgaa gagtatcttt cccgcgcgag gcataaagtt gcgtgtgatg 7440 cggaagggtc ccggcacctc ggaacggttg ttaattacct gggcggcgag cacgatctcg 7500 tcaaagccgt tgatgttgtg gcccacaatg taaagttcca agaagcgcgg gatgcccttg 7560 atggaaggca attttttaag ttcctcgtag gtgagctctt caggggagct gagcccgtgc 7620 tctgaaaggg cccagtctgc aagatgaggg ttggaagcga cgaatgagct ccacaggtca 7680 cgggccatta gcatttgcag gtggtcgcga aaggtcctaa actggcgacc tatggccatt 7740 ttttctgggg tgatgcagta gaaggtaagc gggtcttgtt cccagcggtc ccatccaagg 7800 ttcgcggcta ggtctcgcgc ggcagtcact agaggctcat ctccgccgaa cttcatgacc 7860 agcatgaagg gcacgagctg cttcccaaag gcccccatcc aagtataggt ctctacatcg 7920 taggtgacaa agagacgctc ggtgcgagga tgcgagccga tcgggaagaa ctggatctcc 7980 cgccaccaat tggaggagtg gctattgatg tggtgaaagt agaagtccct gcgacgggcc 8040 gaacactcgt gctggctttt gtaaaaacgt gcgcagtact ggcagcggtg cacgggctgt 8100 acatcctgca cgaggttgac ctgacgaccg cgcacaagga agcagagtgg gaatttgagc 8160 ccctcgcctg gcgggtttgg ctggtggtct tctacttcgg ctgcttgtcc ttgaccgtct 8220 ggctgctcga ggggagttac ggtggatcgg accaccacgc cgcgcgagcc caaagtccag 8280 atgtccgcgc gcggcggtcg gagcttgatg acaacatcgc gcagatggga gctgtccatg 8340 gtctggagct cccgcggcgt caggtcaggc gggagctcct gcaggtttac ctcgcataga 8400 cgggtcaggg cgcgggctag atccaggtga tacctaattt ccaggggctg gttggtggcg 8460 gcgtcgatgg cttgcaagag gccgcatccc cgcggcgcga ctacggtacc gcgcggcggg 8520 cggtgggccg cgggggtgtc cttggatgat gcatctaaaa gcggtgacgc gggcgagccc 8580 ccggaggtag ggggggctcc ggacccgccg ggagaggggg caggggcacg tcggcgccgc 8640 gcgcgggcag gagctggtgc tgcgcgcgta ggttgctggc gaacgcgacg acgcggcggt 8700 tgatctcctg aatctggcgc ctctgcgtga agacgacggg cccggtgagc ttgagcctga 8760 aagagagttc gacagaatca atttcggtgt cgttgacggc ggcctggcgc aaaatctcct 8820 gcacgtctcc tgagttgtct tgataggcga tctcggccat gaactgctcg atctcttcct 8880 cctggagatc tccgcgtccg gctcgctcca cggtggcggc gaggtcgttg gaaatgcggg 8940 ccatgagctg cgagaaggcg ttgaggcctc cctcgttcca gacgcggctg tagaccacgc 9000 ccccttcggc atcgcgggcg cgcatgacca cctgcgcgag attgagctcc acgtgccggg 9060 cgaagacggc gtagtttcgc aggcgctgaa agaggtagtt gagggtggtg gcggtgtgtt 9120 ctgccacgaa gaagtacata acccagcgtc gcaacgtgga ttcgttgata tcccccaagg 9180 cctcaaggcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc 9240 gcgccgacac ggttaactcc tcctccagaa gacggatgag ctcggcgaca gtgtcgcgca 9300 cctcgcgctc aaaggctaca ggggcctctt cttcttcttc aatctcctct tccataaggg 9360 cctccccttc ttcttcttct ggcggcggtg ggggaggggg gacacggcgg cgacgacggc 9420 gcaccgggag gcggtcgaca aagcgctcga tcatctcccc gcggcgacgg cgcatggtct 9480 cggtgacggc gcggccgttc tcgcgggggc gcagttggaa gacgccgccc gtcatgtccc 9540 ggttatgggt tggcgggggg ctgccatgcg gcagggatac ggcgctaacg atgcatctca 9600 acaattgttg tgtaggtact ccgccgccga gggacctgag cgagtccgca tcgaccggat 9660 cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc gcaaggtagg ctgagcaccg 9720 tggcgggcgg cagcgggcgg cggtcggggt tgtttctggc ggaggtgctg ctgatgatgt 9780 aattaaagta ggcggtcttg agacggcgga tggtcgacag aagcaccatg tccttgggtc 9840 cggcctgctg aatgcgcagg cggtcggcca tgccccaggc ttcgttttga catcggcgca 9900 ggtctttgta gtagtcttgc atgagccttt ctaccggcac ttcttcttct ccttcctctt 9960 gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga gtttggccgt aggtggcgcc 10020 ctcttcctcc catgcgtgtg accccgaagc ccctcatcgg ctgaagcagg gctaggtcgg 10080 cgacaacgcg ctcggctaat atggcctgct gcacctgcgt gagggtagac tggaagtcat 10140 ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt gtaagtgcag ttggccataa 10200 cggaccagtt aacggtctgg tgacccggct gcgagagctc ggtgtacctg agacgcgagt 10260 aagccctcga gtcaaatacg tagtcgttgc aagtccgcac caggtactgg tatcccacca 10320 aaaagtgcgg cggcggctgg cggtagaggg gccagcgtag ggtggccggg gctccggggg 10380 cgagatcttc caacataagg cgatgatatc cgtagatgta cctggacatc caggtgatgc 10440 cggcggcggt ggtggaggcg cgcggaaagt cgcggacgcg gttccagatg ttgcgcagcg 10500 gcaaaaagtg ctccatggtc gggacgctct ggccggtcag gcgcgcgcaa tcgttgacgc 10560 tctagaccgt gcaaaaggag agcctgtaag cgggcactct tccgtggtct ggtggataaa 10620 ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc cgtatccggc cgtccgccgt 10680 gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga caacggggga 10740 gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc gctagctttt ttggccactg 10800 gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc tcgctccctg 10860 tagccggagg gttattttcc aagggttgag tcgcgggacc cccggttcga gtctcggacc 10920 ggccggactg cggcgaacgg gggtttgcct ccccgtcatg caagaccccg cttgcaaatt 10980 cctccggaaa cagggacgag cccctttttt gcttttccca gatgcatccg gtgctgcggc 11040 agatgcgccc ccctcctcag cagcggcaag agcaagagca gcggcagaca tgcagggcac 11100 cctcccctcc tcctaccgcg tcaggagggg cgacatccgc ggttgacgcg gcagcagatg 11160 gtgattacga acccccgcgg cgccgggccc ggcactacct ggacttggag gagggcgagg 11220 gcctggcgcg gctaggagcg ccctctcctg agcggtaccc aagggtgcag ctgaagcgtg 11280 atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg cgaccgcgag ggagaggagc 11340 ccgaggagat gcgggatcga aagttccacg cagggcgcga gctgcggcat ggcctgaatc 11400 gcgagcggtt gctgcgcgag gaggactttg agcccgacgc gcgaaccggg attagtcccg 11460 cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata cgagcagacg gtgaaccagg 11520 agattaactt tcaaaaaagc tttaacaacc acgtgcgtac gcttgtggcg cgcgaggagg 11580 tggctatagg actgatgcat ctgtgggact ttgtaagcgc gctggagcaa aacccaaata 11640 gcaagccgct catggcgcag ctgttcctta tagtgcagca cagcagggac aacgaggcat 11700 tcagggatgc gctgctaaac atagtagagc ccgagggccg ctggctgctc gatttgataa 11760 acatcctgca gagcatagtg gtgcaggagc gcagcttgag cctggctgac aaggtggccg 11820 ccatcaacta ttccatgctt agcctgggca agttttacgc ccgcaagata taccataccc 11880 cttacgttcc catagacaag gaggtaaaga tcgaggggtt ctacatgcgc atggcgctga 11940 aggtgcttac cttgagcgac gacctgggcg tttatcgcaa cgagcgcatc cacaaggccg 12000 tgagcgtgag ccggcggcgc gagctcagcg accgcgagct gatgcacagc ctgcaaaggg 12060 ccctggctgg cacgggcagc ggcgatagag aggccgagtc ctactttgac gcgggcgctg 12120 acctgcgctg ggccccaagc cgacgcgccc tggaggcagc tggggccgga cctgggctgg 12180 cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga ggaatatgac gaggacgatg 12240 agtacgagcc agaggacggc gagtactaag cggtgatgtt tctgatcaga tgatgcaaga 12300 cgcaacggac ccggcggtgc gggcggcgct gcagagccag ccgtccggcc ttaactccac 12360 ggacgactgg cgccaggtca tggaccgcat catgtcgctg actgcgcgca atcctgacgc 12420 gttccggcag cagccgcagg ccaaccggct ctccgcaatt ctggaagcgg tggtcccggc 12480 gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta aacgcgctgg ccgaaaacag 12540 ggccatccgg cccgacgagg ccggcctggt ctacgacgcg ctgcttcagc gcgtggctcg 12600 ttacaacagc ggcaacgtgc agaccaacct ggaccggctg gtgggggatg tgcgcgaggc 12660 cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg ggctccatgg ttgcactaaa 12720 cgccttcctg agtacacagc ccgccaacgt gccgcgggga caggaggact acaccaactt 12780 tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa agtgaggtgt accagtctgg 12840 gccagactat tttttccaga ccagtagaca aggcctgcag accgtaaacc tgagccaggc 12900 tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc acaggcgacc gcgcgaccgt 12960 gtctagcttg ctgacgccca actcgcgcct gttgctgctg ctaatagcgc ccttcacgga 13020 cagtggcagc gtgtcccggg acacatacct aggtcacttg ctgacactgt accgcgaggc 13080 cataggtcag gcgcatgtgg acgagcatac tttccaggag attacaagtg tcagccgcgc 13140 gctggggcag gaggacacgg gcagcctgga ggcaacccta aactacctgc tgaccaaccg 13200 gcggcagaag atcccctcgt tgcacagttt aaacagcgag gaggagcgca ttttgcgcta 13260 cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg gtaacgccca gcgtggcgct 13320 ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc tcaaaccggc cgtttatcaa 13380 ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac cccgagtatt tcaccaatgc 13440 catcttgaac ccgcactggc taccgccccc tggtttctac accgggggat tcgaggtgcc 13500 cgagggtaac gatggattcc tctgggacga catagacgac agcgtgtttt ccccgcaacc 13560 gcagaccctg ctagagttgc aacagcgcga gcaggcagag gcggcgctgc gaaaggaaag 13620 cttccgcagg ccaagcagct tgtccgatct aggcgctgcg gccccgcggt cagatgctag 13680 tagcccattt ccaagcttga tagggtctct taccagcact cgcaccaccc gcccgcgcct 13740 gctgggcgag gaggagtacc taaacaactc gctgctgcag ccgcagcgcg aaaaaaacct 13800 gcctccggca tttcccaaca acgggataga gagcctagtg gacaagatga gtagatggaa 13860 gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc ccgcccaccc gtcgtcaaag 13920 gcacgaccgt cagcggggtc tggtgtggga ggacgatgac tcggcagacg acagcagcgt 13980 cctggatttg ggagggagtg gcaacccgtt tgcgcacctt cgccccaggc tggggagaat 14040 gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc accaaggcca tggcaccgag 14100 cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg cgatgtatga ggaaggtcct 14160 cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg cggcggcgct gggttctccc 14220 ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt acctgcggcc taccgggggg 14280 agaaacagca tccgttactc tgagttggca cccctattcg acaccacccg tgtgtacctg 14340 gtggacaaca agtcaacgga tgtggcatcc ctgaactacc agaacgacca cagcaacttt 14400 ctgaccacgg tcattcaaaa caatgactac agcccggggg aggcaagcac acagaccatc 14460 aatcttgacg accggtcgca ctggggcggc gacctgaaaa ccatcctgca taccaacatg 14520 ccaaatgtga acgagttcat gtttaccaat aagtttaagg cgcgggtgat ggtgtcgcgc 14580 ttgcctacta aggacaatca ggtggagctg aaatacgagt gggtggagtt cacgctgccc 14640 gagggcaact actccgagac catgaccata gaccttatga acaacgcgat cgtggagcac 14700 tacttgaaag tgggcagaca gaacggggtt ctggaaagcg acatcggggt aaagtttgac 14760 acccgcaact tcagactggg gtttgacccc gtcactggtc ttgtcatgcc tggggtatat 14820 acaaacgaag ccttccatcc agacatcatt ttgctgccag gatgcggggt ggacttcacc 14880 cacagccgcc tgagcaactt gttgggcatc cgcaagcggc aacccttcca ggagggcttt 14940 aggatcacct acgatgatct ggagggtggt aacattcccg cactgttgga tgtggacgcc 15000 taccaggcga gcttgaaaga tgacaccgaa cagggcgggg gtggcgcagg cggcagcaac 15060 agcagtggca gcggcgcgga agagaactcc aacgcggcag ccgcggcaat gcagccggtg 15120 gaggacatga acgatcatgc cattcgcggc gacacctttg ccacacgggc tgaggagaag 15180 cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg ctgcgcaacc cgaggtcgag 15240 aagcctcaga agaaaccggt gatcaaaccc ctgacagagg acagcaagaa acgcagttac 15300 aacctaataa gcaatgacag caccttcacc cagtaccgca gctggtacct tgcatacaac 15360 tacggcgacc ctcagaccgg aatccgctca tggaccctgc tttgcactcc tgacgtaacc 15420 tgcggctcgg agcaggtcta ctggtcgttg ccagacatga tgcaagaccc cgtgaccttc 15480 cgctccacgc gccagatcag caactttccg gtggtgggcg ccgagctgtt gcccgtgcac 15540 tccaagagct tctacaacga ccaggccgtc tactcccaac tcatccgcca gtttacctct 15600 ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc gccagccccc 15660 accatcacca ccgtcagtga aaacgttcct gctctcacag atcacgggac gctaccgctg 15720 cgcaacagca tcggaggagt ccagcgagtg accattactg acgccagacg ccgcacctgc 15780 ccctacgttt acaaggccct gggcatagtc tcgccgcgcg tcctatcgag ccgcactttt 15840 tgagcaagca tgtccatcct tatatcgccc agcaataaca caggctgggg cctgcgcttc 15900 ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc aacacccagt gcgcgtgcgc 15960 gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc gcactgggcg caccaccgtc 16020 gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact acacgcccac gccgccacca 16080 gtgtccacag tggacgcggc cattcagacc gtggtgcgcg gagcccggcg ctatgctaaa 16140 atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc gccgacccgg cactgccgcc 16200 caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca ccggccgacg ggcggccatg 16260 cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc cccccaggtc caggcgacga 16320 gcggccgccg cagcagccgc ggccattagt gctatgactc agggtcgcag gggcaacgtg 16380 tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg tgcgcacccg ccccccgcgc 16440 aactagattg caagaaaaaa ctacttagac tcgtactgtt gtatgtatcc agcggcggcg 16500 gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag agatgctcca ggtcatcgcg 16560 ccggagatct atggcccccc gaagaaggaa gagcaggatt acaagccccg aaagctaaag 16620 cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg acgacgaggt ggaactgctg 16680 cacgctaccg cgcccaggcg acgggtacag tggaaaggtc gacgcgtaaa acgtgttttg 16740 cgacccggca ccaccgtagt ctttacgccc ggtgagcgct ccacccgcac ctacaagcgc 16800 gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc aggccaacga gcgcctcggg 16860 gagtttgcct acggaaagcg gcataaggac atgctggcgt tgccgctgga cgagggcaac 16920 ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc tgcccgcgct tgcaccgtcc 16980 gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg cacccaccgt gcagctgatg 17040 gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa tgaccgtgga acctgggctg 17100 gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc cgggactggg cgtgcagacc 17160 gtggacgttc agatacccac taccagtagc accagtattg ccaccgccac agagggcatg 17220 gagacacaaa cgtccccggt tgcctcagcg gtggcggatg ccgcggtgca ggcggtcgct 17280 gcggccgcgt ccaagacctc tacggaggtg caaacggacc cgtggatgtt tcgcgtttca 17340 gccccccggc gcccgcgcgg ttcgaggaag tacggcgccg ccagcgcgct actgcccgaa 17400 tatgccctac atccttccat tgcgcctacc cccggctatc gtggctacac ctaccgcccc 17460 agaagacgag caactacccg acgccgaacc accactggaa cccgccgccg ccgtcgccgt 17520 cgccagcccg tgctggcccc gatttccgtg cgcagggtgg ctcgcgaagg aggcaggacc 17580 ctggtgctgc caacagcgcg ctaccacccc agcatcgttt aaaagccggt ctttgtggtt 17640 cttgcagata tggccctcac ctgccgcctc cgtttcccgg tgccgggatt ccgaggaaga 17700 atgcaccgta ggaggggcat ggccggccac ggcctgacgg gcggcatgcg tcgtgcgcac 17760 caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg gtatcctgcc cctccttatt 17820 ccactgatcg ccgcggcgat tggcgccgtg cccggaattg catccgtggc cttgcaggcg 17880 cagagacact gattaaaaac aagttgcatg tggaaaaatc aaaataaaaa gtctggactc 17940 tcacgctcgc ttggtcctgt aactattttg tagaatggaa gacatcaact ttgcgtctct 18000 ggccccgcga cacggctcgc gcccgttcat gggaaactgg caagatatcg gcaccagcaa 18060 tatgagcggt ggcgccttca gctggggctc gctgtggagc ggcattaaaa atttcggttc 18120 caccgttaag aactatggca gcaaggcctg gaacagcagc acaggccaga tgctgaggga 18180 taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat ggcctggcct ctggcattag 18240 cggggtggtg gacctggcca accaggcagt gcaaaataag attaacagta agcttgatcc 18300 ccgccctccc gtagaggagc ctccaccggc cgtggagaca gtgtctccag aggggcgtgg 18360 cgaaaagcgt ccgcgccccg acagggaaga aactctggtg acgcaaatag acgagcctcc 18420 ctcgtacgag gaggcactaa agcaaggcct gcccaccacc cgtcccatcg cgcccatggc 18480 taccggagtg ctgggccagc acacacccgt aacgctggac ctgcctcccc ccgccgacac 18540 ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt gtaacccgtc ctagccgcgc 18600 gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg cccgtagcca gtggcaactg 18660 gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa tccctgaagc gccgacgatg 18720 cttctgaata gctaacgtgt cgtatgtgtg tcatgtatgc gtccatgtcg ccgccagagg 18780 agctgctgag ccgccgcgcg cccgctttcc aagatggcta ccccttcgat gatgccgcag 18840 tggtcttaca tgcacatctc gggccaggac gcctcggagt acctgagccc cgggctggtg 18900 cagtttgccc gcgccaccga gacgtacttc agcctgaata acaagtttag aaaccccacg 18960 gtggcgccta cgcacgacgt gaccacagac cggtcccagc gtttgacgct gcggttcatc 19020 cctgtggacc gtgaggatac tgcgtactcg tacaaggcgc ggttcaccct agctgtgggt 19080 gataaccgtg tgctggacat ggcttccacg tactttgaca tccgcggcgt gctggacagg 19140 ggccctactt ttaagcccta ctctggcact gcctacaacg ccctggctcc caagggtgcc 19200 ccaaatcctt gcgaatggga tgaagctgct actgctcttg aaataaacct agaagaagag 19260 gacgatgaca acgaagacga agtagacgag caagctgagc agcaaaaaac tcacgtattt 19320 gggcaggcgc cttattctgg tataaatatt acaaaggagg gtattcaaat aggtgtcgaa 19380 ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg aacctcaaat aggagaatct 19440 cagtggtacg aaactgaaat taatcatgca gctgggagag tccttaaaaa gactacccca 19500 atgaaaccat gttacggttc atatgcaaaa cccacaaatg aaaatggagg gcaaggcatt 19560 cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg aaatgcaatt tttctcaact 19620 actgaggcga ccgcaggcaa tggtgataac ttgactccta aagtggtatt gtacagtgaa 19680 gatgtagata tagaaacccc agacactcat atttcttaca tgcccactat taaggaaggt 19740 aactcacgag aactaatggg ccaacaatct atgcccaaca ggcctaatta cattgctttt 19800 agggacaatt ttattggtct aatgtattac aacagcacgg gtaatatggg tgttctggcg 19860 ggccaagcat cgcagttgaa tgctgttgta gatttgcaag acagaaacac agagctttca 19920 taccagcttt tgcttgattc cattggtgat agaaccaggt acttttctat gtggaatcag 19980 gctgttgaca gctatgatcc agatgttaga attattgaaa atcatggaac tgaagatgaa 20040 cttccaaatt actgctttcc actgggaggt gtgattaata cagagactct taccaaggta 20100 aaacctaaaa caggtcagga aaatggatgg gaaaaagatg ctacagaatt ttcagataaa 20160 aatgaaataa gagttggaaa taattttgcc atggaaatca atctaaatgc caacctgtgg 20220 agaaatttcc tgtactccaa catagcgctg tatttgcccg acaagctaaa gtacagtcct 20280 tccaacgtaa aaatttctga taacccaaac acctacgact acatgaacaa gcgagtggtg 20340 gctcccgggt tagtggactg ctacattaac cttggagcac gctggtccct tgactatatg 20400 gacaacgtca acccatttaa ccaccaccgc aatgctggcc tgcgctaccg ctcaatgttg 20460 ctgggcaatg gtcgctatgt gcccttccac atccaggtgc ctcagaagtt ctttgccatt 20520 aaaaacctcc ttctcctgcc gggctcatac acctacgagt ggaacttcag gaaggatgtt 20580 aacatggttc tgcagagctc cctaggaaat gacctaaggg ttgacggagc cagcattaag 20640 tttgatagca tttgccttta cgccaccttc ttccccatgg cccacaacac cgcctccacg 20700 cttgaggcca tgcttagaaa cgacaccaac gaccagtcct ttaacgacta tctctccgcc 20760 gccaacatgc tctaccctat acccgccaac gctaccaacg tgcccatatc catcccctcc 20820 cgcaactggg cggctttccg cggctgggcc ttcacgcgcc ttaagactaa ggaaacccca 20880 tcactgggct cgggctacga cccttattac acctactctg gctctatacc ctacctagat 20940 ggaacctttt acctcaacca cacctttaag aaggtggcca ttacctttga ctcttctgtc 21000 agctggcctg gcaatgaccg cctgcttacc cccaacgagt ttgaaattaa gcgctcagtt 21060 gacggggagg gttacaacgt tgcccagtgt aacatgacca aagactggtt cctggtacaa 21120 atgctagcta actacaacat tggctaccag ggcttctata tcccagagag ctacaaggac 21180 cgcatgtact ccttctttag aaacttccag cccatgagcc gtcaggtggt ggatgatact 21240 aaatacaagg actaccaaca ggtgggcatc ctacaccaac acaacaactc tggatttgtt 21300 ggctaccttg cccccaccat gcgcgaagga caggcctacc ctgctaactt cccctatccg 21360 cttataggca agaccgcagt tgacagcatt acccagaaaa agtttctttg cgatcgcacc 21420 ctttggcgca tcccattctc cagtaacttt atgtccatgg gcgcactcac agacctgggc 21480 caaaaccttc tctacgccaa ctccgcccac gcgctagaca tgacttttga ggtggatccc 21540 atggacgagc ccacccttct ttatgttttg tttgaagtct ttgacgtggt ccgtgtgcac 21600 cggccgcacc gcggcgtcat cgaaaccgtg tacctgcgca cgcccttctc ggccggcaac 21660 gccacaacat aaagaagcaa gcaacatcaa caacagctgc cgccatgggc tccagtgagc 21720 aggaactgaa agccattgtc aaagatcttg gttgtgggcc atattttttg ggcacctatg 21780 acaagcgctt tccaggcttt gtttctccac acaagctcgc ctgcgccata gtcaatacgg 21840 ccggtcgcga gactgggggc gtacactgga tggcctttgc ctggaacccg cactcaaaaa 21900 catgctacct ctttgagccc tttggctttt ctgaccagcg actcaagcag gtttaccagt 21960 ttgagtacga gtcactcctg cgccgtagcg ccattgcttc ttcccccgac cgctgtataa 22020 cgctggaaaa gtccacccaa agcgtacagg ggcccaactc ggccgcctgt ggactattct 22080 gctgcatgtt tctccacgcc tttgccaact ggccccaaac tcccatggat cacaacccca 22140 ccatgaacct tattaccggg gtacccaact ccatgctcaa cagtccccag gtacagccca 22200 ccctgcgtcg caaccaggaa cagctctaca gcttcctgga gcgccactcg ccctacttcc 22260 gcagccacag tgcgcagatt aggagcgcca cttctttttg tcacttgaaa aacatgtaaa 22320 aataatgtac tagagacact ttcaataaag gcaaatgctt ttatttgtac actctcgggt 22380 gattatttac ccccaccctt gccgtctgcg ccgtttaaaa atcaaagggg ttctgccgcg 22440 catcgctatg cgccactggc agggacacgt tgcgatactg gtgtttagtg ctccacttaa 22500 actcaggcac aaccatccgc ggcagctcgg tgaagttttc actccacagg ctgcgcacca 22560 tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa gtcgcagttg gggcctccgc 22620 cctgcgcgcg cgagttgcga tacacagggt tgcagcactg gaacactatc agcgccgggt 22680 ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc cgcgtccagg tcctccgcgt 22740 tgctcagggc gaacggagtc aactttggta gctgccttcc caaaaagggc gcgtgcccag 22800 gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg accgtgcccg gtctgggcgt 22860 taggatacag cgcctgcata aaagccttga tctgcttaaa agccacctga gcctttgcgc 22920 cttcagagaa gaacatgccg caagacttgc cggaaaactg attggccgga caggccgcgt 22980 cgtgcacgca gcaccttgcg tcggtgttgg agatctgcac cacatttcgg ccccaccggt 23040 tcttcacgat cttggccttg ctagactgct ccttcagcgc gcgctgcccg ttttcgctcg 23100 tcacatccat ttcaatcacg tgctccttat ttatcataat gcttccgtgt agacacttaa 23160 gctcgccttc gatctcagcg cagcggtgca gccacaacgc gcagcccgtg ggctcgtgat 23220 gcttgtaggt cacctctgca aacgactgca ggtacgcctg caggaatcgc cccatcatcg 23280 tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc gcggtgctcc tcgttcagcc 23340 aggtcttgca tacggccgcc agagcttcca cttggtcagg cagtagtttg aagttcgcct 23400 ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg cgcagcctcc atgcccttct 23460 cccacgcaga cacgatcggc acactcagcg ggttcatcac cgtaatttca ctttccgctt 23520 cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg cgccactggg tcgtcttcat 23580 tcagccgccg cactgtgcgc ttacctcctt tgccatgctt gattagcacc ggtgggttgc 23640 tgaaacccac catttgtagc gccacatctt ctctttcttc ctcgctgtcc acgattacct 23700 ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt ctttttcttc ttgggcgcaa 23760 tggccaaatc cgccgccgag gtcgatggcc gcgggctggg tgtgcgcggc accagcgcgt 23820 cttgtgatga gtcttcctcg tcctcggact cgatacgccg cctcatccgc ttttttgggg 23880 gcgcccgggg aggcggcggc gacggggacg gggacgacac gtcctccatg gttgggggac 23940 gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg ctgctcctct tcccgactgg 24000 ccatttcctt ctcctatagg cagaaaaaga tcatggagtc agtcgagaag aaggacagcc 24060 taaccgcccc ctctgagttc gccaccaccg cctccaccga tgccgccaac gcgcctacca 24120 ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt gattatcgag caggacccag 24180 gttttgtaag cgaagacgac gaggaccgct cagtaccaac agaggataaa aagcaagacc 24240 aggacaacgc agaggcaaac gaggaacaag tcgggcgggg ggacgaaagg catggcgact 24300 acctagatgt gggagacgac gtgctgttga agcatctgca gcgccagtgc gccattatct 24360 gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat agcggatgtc agccttgcct 24420 acgaacgcca cctattctca ccgcgcgtac cccccaaacg ccaagaaaac ggcacatgcg 24480 agcccaaccc gcgcctcaac ttctaccccg tatttgccgt gccagaggtg cttgccacct 24540 atcacatctt tttccaaaac tgcaagatac ccctatcctg ccgtgccaac cgcagccgag 24600 cggacaagca gctggccttg cggcagggcg ctgtcatacc tgatatcgcc tcgctcaacg 24660 aagtgccaaa aatctttgag ggtcttggac gcgacgagaa gcgcgcggca aacgctctgc 24720 aacaggaaaa cagcgaaaat gaaagtcact ctggagtgtt ggtggaactc gagggtgaca 24780 acgcgcgcct agccgtacta aaacgcagca tcgaggtcac ccactttgcc tacccggcac 24840 ttaacctacc ccccaaggtc atgagcacag tcatgagtga gctgatcgtg cgccgtgcgc 24900 agcccctgga gagggatgca aatttgcaag aacaaacaga ggagggccta cccgcagttg 24960 gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc tgccgacttg gaggagcgac 25020 gcaaactaat gatggccgca gtgctcgtta ccgtggagct tgagtgcatg cagcggttct 25080 ttgctgaccc ggagatgcag cgcaagctag aggaaacatt gcactacacc tttcgacagg 25140 gctacgtacg ccaggcctgc aagatctcca acgtggagct ctgcaacctg gtctcctacc 25200 ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct tcattccacg ctcaagggcg 25260 aggcgcgccg cgactacgtc cgcgactgcg tttacttatt tctatgctac acctggcaga 25320 cggccatggg cgtttggcag cagtgcttgg aggagtgcaa cctcaaggag ctgcagaaac 25380 tgctaaagca aaacttgaag gacctatgga cggccttcaa cgagcgctcc gtggccgcgc 25440 acctggcgga catcattttc cccgaacgcc tgcttaaaac cctgcaacag ggtctgccag 25500 acttcaccag tcaaagcatg ttgcagaact ttaggaactt tatcctagag cgctcaggaa 25560 tcttgcccgc cacctgctgt gcacttccta gcgactttgt gcccattaag taccgcgaat 25620 gccctccgcc gctttggggc cactgctacc ttctgcagct agccaactac cttgcctacc 25680 actctgacat aatggaagac gtgagcggtg acggtctact ggagtgtcac tgtcgctgca 25740 acctatgcac cccgcaccgc tccctggttt gcaattcgca gctgcttaac gaaagtcaaa 25800 ttatcggtac ctttgagctg cagggtccct cgcctgacga aaagtccgcg gctccggggt 25860 tgaaactcac tccggggctg tggacgtcgg cttaccttcg caaatttgta cctgaggact 25920 accacgccca cgagattagg ttctacgaag accaatcccg cccgccaaat gcggagctta 25980 ccgcctgcgt cattacccag ggccacattc ttggccaatt gcaagccatc aacaaagccc 26040 gccaagagtt tctgctacga aagggacggg gggtttactt ggacccccag tccggcgagg 26100 agctcaaccc aatccccccg ccgccgcagc cctatcagca gcagccgcgg gcccttgctt 26160 cccaggatgg cacccaaaaa gaagctgcag ctgccgccgc cacccacgga cgaggaggaa 26220 tactgggaca gtcaggcaga ggaggttttg gacgaggagg aggaggacat gatggaagac 26280 tgggagagcc tagacgagga agcttccgag gtcgaagagg tgtcagacga aacaccgtca 26340 ccctcggtcg cattcccctc gccggcgccc cagaaatcgg caaccggttc cagcatggct 26400 acaacctccg ctcctcaggc gccgccggca ctgcccgttc gccgacccaa ccgtagatgg 26460 gacaccactg gaaccagggc cggtaagtcc aagcagccgc cgccgttagc ccaagagcaa 26520 caacagcgcc aaggctaccg ctcatggcgc gggcacaaga acgccatagt tgcttgcttg 26580 caagactgtg ggggcaacat ctccttcgcc cgccgctttc ttctctacca tcacggcgtg 26640 gccttccccc gtaacatcct gcattactac cgtcatctct acagcccata ctgcaccggc 26700 ggcagcggca gcggcagcaa cagcagcggc cacacagaag caaaggcgac cggatagcaa 26760 gactctgaca aagcccaaga aatccacagc ggcggcagca gcaggaggag gagcgctgcg 26820 tctggcgccc aacgaacccg tatcgacccg cgagcttaga aacaggattt ttcccactct 26880 gtatgctata tttcaacaga gcaggggcca agaacaagag ctgaaaataa aaaacaggtc 26940 tctgcgatcc ctcacccgca gctgcctgta tcacaaaagc gaagatcagc ttcggcgcac 27000 gctggaagac gcggaggctc tcttcagtaa atactgcgcg ctgactctta aggactagtt 27060 tcgcgccctt tctcaaattt aagcgcgaaa actacgtcat ctccagcggc cacacccggc 27120 gccagcacct gtcgtcagcg ccatttatga gcaaggaaat tcccacgccc tacatgtgga 27180 gttaccagcc acaaatggga cttgcggctg gagctgccca agactactca acccgaataa 27240 actacatgag cgcgggaccc cacatgatat cccgggtcaa cggaatacgc gcccaccgaa 27300 accgaattct cctggaacag gcggctatta ccaccacacc tcgtaataac cttaatcccc 27360 gtagttggcc cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc 27420 ccagagacgc ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct 27480 ttcgtcacag ggtgcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag 27540 gtattcagct caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat 27600 ttcagatcgg cggcgccggc cgctcttcat tcacgcctcg tcaggcaatc ctaactctgc 27660 agacctcgtc ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt 27720 ttgtgccatc ggtctacttt aaccccttct cgggacctcc cggccactat ccggatcaat 27780 ttattcctaa ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg 27840 gagaggcaga gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg 27900 cccgcgactc cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg 27960 cgcacggcgt ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta 28020 cccagcgccc cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca 28080 actgtcctaa ccctggatta catcaagatc tttgttgcca tctctgtgct gagtataata 28140 aatacagaaa ttaaaatata ctggggctcc tatcgccatc ctgtaaacgc caccgtcttc 28200 acccgcccaa gcaaaccaag gcgaacctta cctggtactt ttaacatctc tccctctgtg 28260 atttacaaca gtttcaaccc agacggagtg agtctacgag agaacctctc cgagctcagc 28320 tactccatca gaaaaaacac caccctcctt acctgccggg aacgtacgag tgcgtcaccg 28380 gccgctgcac cacacctacc gcctgaccgt aaaccagact ttttccggac agacctcaat 28440 aactctgttt accagaacag gaggtgagct tagaaaaccc ttagggtatt aggccaaagg 28500 cgcagctact gtggggttta tgaacaattc aagcaactct acgggctatt ctaattcagg 28560 tttctctaga atcggggttg gggttattct ctgtcttgtg attctcttta ttcttatact 28620 aacgcttctc tgcctaaggc tcgccgcctg ctgtgtgcac atttgcattt attgtcagct 28680 ttttaaacgc tggggtcgcc acccaagatg attaggtaca taatcctagg tttactcacc 28740 cttgcgtcag cccacggtac cacccaaaag gtggatttta aggagccagc ctgtaatgtt 28800 acattcgcag ctgaagctaa tgagtgcacc actcttataa aatgcaccac agaacatgaa 28860 aagctgctta ttcgccacaa aaacaaaatt ggcaagtatg ctgtttatgc tatttggcag 28920 ccaggtgaca ctacagagta taatgttaca gttttccagg gtaaaagtca taaaactttt 28980 atgtatactt ttccatttta tgaaatgtgc gacattacca tgtacatgag caaacagtat 29040 aagttgtggc ccccacaaaa ttgtgtggaa aacactggca ctttctgctg cactgctatg 29100 ctaattacag tgctcgcttt ggtctgtacc ctactctata ttaaatacaa aagcagacgc 29160 agctttattg aggaaaagaa aatgccttaa tttactaagt tacaaagcta atgtcaccac 29220 taactgcttt actcgctgct tgcaaaacaa attcaaaaag ttagcattat aattagaata 29280 ggatttaaac cccccggtca tttcctgctc aataccattc ccctgaacaa ttgactctat 29340 gtgggatatg ctccagcgct acaaccttga agtcaggctt cctggatgtc agcatctgac 29400 tttggccagc acctgtcccg cggatttgtt ccagtccaac tacagcgacc caccctaaca 29460 gagatgacca acacaaccaa cgcggccgcc gctaccggac ttacatctac cacaaataca 29520 ccccaagttt ctgcctttgt caataactgg gataacttgg gcatgtggtg gttctccata 29580 gcgcttatgt ttgtatgcct tattattatg tggctcatct gctgcctaaa gcgcaaacgc 29640 gcccgaccac ccatctatag tcccatcatt gtgctacacc caaacaatga tggaatccat 29700 agattggacg gactgaaaca catgttcttt tctcttacag tatgattaaa tgagacatga 29760 ttcctcgagt ttttatatta ctgacccttg ttgcgctttt ttgtgcgtgc tccacattgg 29820 ctgcggtttc tcacatcgaa gtagactgca ttccagcctt cacagtctat ttgctttacg 29880 gatttgtcac cctcacgctc atctgcagcc tcatcactgt ggtcatcgcc tttatccagt 29940 gcattgactg ggtctgtgtg cgctttgcat atctcagaca ccatccccag tacagggaca 30000 ggactatagc tgagcttctt agaattcttt aattatgaaa tttactgtga cttttctgct 30060 gattatttgc accctatctg cgttttgttc cccgacctcc aagcctcaaa gacatatatc 30120 atgcagattc actcgtatat ggaatattcc aagttgctac aatgaaaaaa gcgatctttc 30180 cgaagcctgg ttatatgcaa tcatctctgt tatggtgttc tgcagtacca tcttagccct 30240 agctatatat ccctaccttg acattggctg gaacgcaata gatgccatga accacccaac 30300 tttccccgcg cccgctatgc ttccactgca acaagttgtt gccggcggct ttgtcccagc 30360 caatcagcct cgcccacctt ctcccacccc cactgaaatc agctacttta atctaacagg 30420 aggagatgac tgacacccta gatctagaaa tggacggaat tattacagag cagcgcctgc 30480 tagaaagacg cagggcagcg gccgagcaac agcgcatgaa tcaagagctc caagacatgg 30540 ttaacttgca ccagtgcaaa aggggtatct tttgtctggt aaagcaggcc aaagtcacct 30600 acgacagtaa taccaccgga caccgcctta gctacaagtt gccaaccaag cgtcagaaat 30660 tggtggtcat ggtgggagaa aagcccatta ccataactca gcactcggta gaaaccgaag 30720 gctgcattca ctcaccttgt caaggacctg aggatctctg cacccttatt aagaccctgt 30780 gcggtctcaa agatcttatt ccctttaact aataaaaaaa aataataaag catcacttac 30840 ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc 30900 cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg 30960 tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag 31020 cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt 31080 cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt 31140 ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt 31200 gcgctcaaaa tgggcaacgg cctctctctg gacgaggccg gcaaccttac ctcccaaaat 31260 gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct 31320 gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc 31380 gcgggcaaca cactcaccat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt 31440 agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca 31500 ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact 31560 actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa 31620 ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac tttgaccgta 31680 gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc 31740 ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat 31800 tctcaaaaca gacgccttat acttgatgtt agttatccgt ttgatgctca aaaccaacta 31860 aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac 31920 tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac 31980 ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat 32040 gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc 32100 catggcctag aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt 32160 tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg 32220 accacaccag ctccatctcc taactgtaga ctaaatgcag agaaagatgc taaactcact 32280 ttggtcttaa caaaatgtgg cagtcaaata cttgctacag tttcagtttt ggctgttaaa 32340 ggcagtttgg ctccaatatc tggaacagtt caaagtgctc atcttattat aagatttgac 32400 gaaaatggag tgctactaaa caattccttc ctggacccag aatattggaa ctttagaaat 32460 ggagatctta ctgaaggcac agcctataca aacgctgttg gatttatgcc taacctatca 32520 gcttatccaa aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca agtttactta 32580 aacggagaca aaactaaacc tgtaacacta accattacac taaacggtac acaggaaaca 32640 ggagacacaa ctccaagtgc atactctatg tcattttcat gggactggtc tggccacaac 32700 tacattaatg aaatatttgc cacatcctct tacacttttt catacattgc ccaagaataa 32760 agaatcgttt gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcgaatca 32820 tttttcattc agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa 32880 tcaaacctac atgggggtag agtcataatc gtgcatcagg atagggcggt ggtgctgcag 32940 cagcgcgcga ataaactgct gccgccgccg ctccgtcctg caggaataca acatggcagt 33000 ggtctcctca gcgatgattc gcaccgcccg cagcataagg cgccttgtcc tccgggcaca 33060 gcagcgcacc ctgatctcac ttaaatcagc acagtaactg cagcacagca ccacaatatt 33120 gttcaaaatc ccacagtgca aggcgctgta tccaaagctc atggcgggga ccacagaacc 33180 cacgtggcca tcataccaca agcgcaggta gattaagtgg cgacccctca taaacacgct 33240 ggacataaac attacctctt ttggcatgtt gtaattcacc acctcccggt accatataaa 33300 cctctgatta aacatggcgc catccaccac catcctaaac cagctggcca aaacctgccc 33360 gccggctata cactgcaggg aaccgggact ggaacaatga cagtggagag cccaggactc 33420 gtaaccatgg atcatcatgc tcgtcatgat atcaatgttg gcacaacaca ggcacacgtg 33480 catacacttc ctcaggatta caagctcctc ccgcgttaga accatatccc agggaacaac 33540 ccattcctga atcagcgtaa atcccacact gcagggaaga cctcgcacgt aactcacgtt 33600 gtgcattgtc aaagtgttac attcgggcag cagcggatga tcctccagta tggtagcgcg 33660 ggtttctgtc tcaaaaggag gtagacgatc cctactgtac ggagtgcgcc gagacaaccg 33720 agatcgtgtt ggtcgtagtg tcatgccaaa tggaacgccg gacgtagtca tatttcctga 33780 agcaaaacca ggtgcgggcg tgacaaacag atctgcgtct ccggtctcgc cgcttagatc 33840 gctctgtgta gtagttgtag tatatccact ctctcaaagc atccaggcgc cccctggctt 33900 cgggttctat gtaaactcct tcatgcgccg ctgccctgat aacatccacc accgcagaat 33960 aagccacacc cagccaacct acacattcgt tctgcgagtc acacacggga ggagcgggaa 34020 gagctggaag aaccatgttt ttttttttat tccaaaagat tatccaaaac ctcaaaatga 34080 agatctatta agtgaacgcg ctcccctccg gtggcgtggt caaactctac agccaaagaa 34140 cagataatgg catttgtaag atgttgcaca atggcttcca aaaggcaaac ggccctcacg 34200 tccaagtgga cgtaaaggct aaacccttca gggtgaatct cctctataaa cattccagca 34260 ccttcaacca tgcccaaata attctcatct cgccaccttc tcaatatatc tctaagcaaa 34320 tcccgaatat taagtccggc cattgtaaaa atctgctcca gagcgccctc caccttcagc 34380 ctcaagcagc gaatcatgat tgcaaaaatt caggttcctc acagacctgt ataagattca 34440 aaagcggaac attaacaaaa ataccgcgat cccgtaggtc ccttcgcagg gccagctgaa 34500 cataatcgtg caggtctgca cggaccagcg cggccacttc cccgccagga accatgacaa 34560 aagaacccac actgattatg acacgcatac tcggagctat gctaaccagc gtagccccga 34620 tgtaagcttg ttgcatgggc ggcgatataa aatgcaaggt gctgctcaaa aaatcaggca 34680 aagcctcgcg caaaaaagaa agcacatcgt agtcatgctc atgcagataa aggcaggtaa 34740 gctccggaac caccacagaa aaagacacca tttttctctc aaacatgtct gcgggtttct 34800 gcataaacac aaaataaaat aacaaaaaaa catttaagcc tgtcttacaa caggaaaaac 34860 aacccttata agcataagac ggactacggc catgccggcg tgaccgtaaa aaaactggtc 34920 accgtgatta aaaagcacca ccgacagctc ctcggtcatg tccggagtca taatgtaaga 34980 ctcggtaaac acatcaggtt gattcacatc ggtcagtgct aaaaagcgac cgaaatagcc 35040 cgggggaata catacccgca ggcgtagaga caacattaca gcccccatag gaggtataac 35100 aaaattaata ggagagaaaa acacataaac acctgaaaaa ccctcctgcc taggcaaaat 35160 agcaccctcc cgctccagaa caacatacag cgcttccaca gcggcagcca taacagtcag 35220 ccttaccagt aaaaaagaaa acctattaaa aaaacaccac tcgacacggc accagctcaa 35280 tcagtcacag tgtaaaaaag ggccaagtgc agagcgagta tatataggac taaaaaatga 35340 cgtaacggtt aaagtccaca aaaaacaccc agaaaaccgc acgcgaacct acgcccagaa 35400 acgaaagcca aaaaacccac aacttcctca aatcgtcact tccgttttcc cacgttacgt 35460 cacttcccat tttaagaaaa ctacaattcc caacacatac aagttactcc gccctaaaac 35520 ctacgtcacc cgccccgttc ccacgccccg cgccacgtca caaactccac cccctcatta 35580 tcatattggc ttcaatccaa aataaggtat attattgatg atg 35623 <210> 24 <211> 35198 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO298) <400> 24 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgaccgaaga aatggccgcc agtcttttgg accagctgat 600 cgaagaggta ctggctgata atcttccacc tcctagccat tttgaaccac ctacccttca 660 cgaactgcat gatttagacg tgacggcccc cgaagatccc aacgaggagg cggtttcgca 720 gatttttccc gactctgtaa tgttggcggt gcaggaaggg attgacttac tcacttttcc 780 gccggcgccc ggttctccgg agccgcctca cctttcccgg cagcccgagc agccggagca 840 gagagccttg ggtccggttt ctatgccaaa ccttgtaccg gaggtgatcg atcttaccgg 900 ccacgaggct ggctttccac ccagtgacga cgaggatgaa gagggtgagg agtttgtgtt 960 agattatgtg gagcaccccg ggcacggttg caggtcttgt cattatcacc ggaggaatac 1020 gggggaccca gatattatgt gttcgctttg ctatatgagg acctgtggca tgtttgtcta 1080 cagtaagtga aaattatggg cagtgggtga tagagtggtg ggtttggtgt ggtaattttt 1140 tttttaattt ttacagtttt gtggtttaaa gaattttgta ttgtgatttt tttaaaaggt 1200 cctgtgtctg aacctgagcc tgagcccgag ccagaaccgg agcctgcaag acctacccgc 1260 cgtcctaaaa tggcgcctgc tatcctgaga cgcccgacat cacctgtgtc tagagaatgc 1320 aatagtagta cggatagctg tgactccggt ccttctaaca cacctcctga gatacacccg 1380 gtggtcccgc tgtgccccat taaaccagtt gccgtgagag ttggtgggcg tcgccaggct 1440 gtggaatgta tcgaggactt gcttaacgag cctgggcaac ctttggactt gagctgtaaa 1500 cgccccaggc cataaggtgt aaacctgtga ttgcgtgtgt ggttaacgcc tttgtttgct 1560 gaatgagttg atgtaagttt aataaagggt gagataatgt ttaacttgca tggcgtgtta 1620 aatggggcgg ggcttaaagg gtatataatg cgccgtgggc taatcttggt tacatctgac 1680 ctcatggagg cttgggagtg tttggaagat ttttctgctg tgcgtaactt gctggaacag 1740 agctctaaca gtacctcttg gttttggagg tttctgtggg gctcatccca ggcaaagtta 1800 gtctgcagaa ttaaggagga ttacaagtgg gaatttgaag agcttttgaa atcctgtggt 1860 gagctgtttg attctttgaa tctgggtcac caggcgcttt tccaagagaa ggtcatcaag 1920 actttggatt tttccacacc ggggcgcgct gcggctgctg ttgctttttt gagttttata 1980 aaggataaat ggagcgaaga aacccatctg agcggggggt acctgctgga ttttctggcc 2040 atgcatctgt ggagagcggt tgtgagacac aagaatcgcc tgctactgtt gtcttccgtc 2100 cgcccggcga taataccgac ggaggagcag cagcagcagc aggaggaagc caggcggcgg 2160 cggcaggagc agagcccatg gaacccgaga gccggcctgg accctcggga atgaatgttg 2220 tacaggtggc tgaactgtat ccagaactga gacgcatttt gacaattaca gaggatgggc 2280 aggggctaaa gggggtaaag agggagcggg gggcttgtga ggctacagag gaggctagga 2340 atctagcttt tagcttaatg accagacacc gtcctgagtg tattactttt caacagatca 2400 aggataattg cgctaatgag cttgatctgc tggcgcagaa gtattccata gagcagctga 2460 ccacttactg gctgcagcca ggggatgatt ttgaggaggc tattagggta tatgcaaagg 2520 tggcacttag gccagattgc aagtacaaga tcagcaaact tgtaaatatc aggaattgtt 2580 gctacatttc tgggaacggg gccgaggtgg agatagatac ggaggatagg gtggccttta 2640 gatgtagcat gataaatatg tggccggggg tgcttggcat ggacggggtg gttattatga 2700 atgtaaggtt tactggcccc aattttagcg gtacggtttt cctggccaat accaacctta 2760 tcctacacgg tgtaagcttc tatgggttta acaatacctg tgtggaagcc tggaccgatg 2820 taagggttcg gggctgtgcc ttttactgct gctggaaggg ggtggtgtgt cgccccaaaa 2880 gcagggcttc aattaagaaa tgcctctttg aaaggtgtac cttgggtatc ctgtctgagg 2940 gtaactccag ggtgcgccac aatgtggcct ccgactgtgg ttgcttcatg ctagtgaaaa 3000 gcgtggctgt gattaagcat aacatggtat gtggcaactg cgaggacagg gcctctcaga 3060 tgctgacctg ctcggacggc aactgtcacc tgctgaagac cattcacgta gccagccact 3120 ctcgcaaggc ctggccagtg tttgagcata acatactgac ccgctgttcc ttgcatttgg 3180 gtaacaggag gggggtgttc ctaccttacc aatgcaattt gagtcacact aagatattgc 3240 ttgagcccga gagcatgtcc aaggtgaacc tgaacggggt gtttgacatg accatgaaga 3300 tctggaaggt gctgaggtac gatgagaccc gcaccaggtg cagaccctgc gagtgtggcg 3360 gtaaacatat taggaaccag cctgtgatgc tggatgtgac cgaggagctg aggcccgatc 3420 acttggtgct ggcctgcacc cgcgctgagt ttggctctag cgatgaagat acagattgag 3480 gtactgaaat gtgtgggcgt ggcttaaggg tgggaaagaa tatataaggt gggggtctta 3540 tgtagttttg tatctgtttt gcagcagccg ccgccgccat gagcaccaac tcgtttgatg 3600 gaagcattgt gagctcatat ttgacaacgc gcatgccccc atgggccggg gtgcgtcaga 3660 atgtgatggg ctccagcatt gatggtcgcc ccgtcctgcc cgcaaactct actaccttga 3720 cctacgagac cgtgtctgga acgccgttgg agactgcagc ctccgccgcc gcttcagccg 3780 ctgcagccac cgcccgcggg attgtgactg actttgcttt cctgagcccg cttgcaagca 3840 gtgcagcttc ccgttcatcc gcccgcgatg acaagttgac ggctcttttg gcacaattgg 3900 attctttgac ccgggaactt aatgtcgttt ctcagcagct gttggatctg cgccagcagg 3960 tttctgccct gaaggcttcc tcccctccca atgcggttta aaacataaat aaaaaaccag 4020 actctgtttg gatttggatc aagcataagt gtcttgctgt ctttatttag gggttttgcg 4080 cgcgcggtag gcccgggacc agcggtctcg gtcgttgagg gtcctgtgta ttttttccag 4140 gacgtggtaa aggtgactct ggatgttcag atacatgggc ataagcccgt ctctggggtg 4200 gaggtagcac cactgcagag cttcatgctg cggggtggtg ttgtagatga tccagtcgta 4260 gcaggagcgc tgggcgtggt gcctaaaaat gtctttcagt agcaagctga ttgccagggg 4320 caggcccttg gtgtaagtgt ttacaaagcg gttaagctgg gatgggtgca tacgtgggga 4380 tatgagatgc atcttggact gtatttttag gttggctatg ttcccagcca tatccctccg 4440 gggattcatg ttgtgcagaa ccaccagcac agtgtatccg gtgcacttgg gaaatttgtc 4500 atgtagctta gaaggaaatg cgtggaagaa cttggagacg cccttgtgac ctccaagatt 4560 ttccatgcat tcgtccataa tgatggcaat gggcccacgg gcggcggcct gggcgaagat 4620 atttctggga tcactaacgt catagttgtg ttccaggatg agatcgtcat aggccatttt 4680 tacaaagcgc gggcggaggg tgccagactg cggtataatg gttccatccg gcccaggggc 4740 gtagttaccc tcacagattt gcatttccca cgctttgagt tcagatgggg ggatcatgtc 4800 tacctgcggg gcgatgaaga aaacggtttc cggggtaggg gagatcagct gggaagaaag 4860 caggttcctg agcagctgcg acttaccgca gccggtgggc ccgtaaatca cacctattac 4920 cgggtgcaac tggtagttaa gagagctgca gctgccgtca tccctgagca ggggggccac 4980 ttcgttaagc atgtccctga ctcgcatgtt ttccctgacc aaatccgcca gaaggcgctc 5040 gccgcccagc gatagcagtt cttgcaagga agcaaagttt ttcaacggtt tgagaccgtc 5100 cgccgtaggc atgcttttga gcgtttgacc aagcagttcc aggcggtccc acagctcggt 5160 cacctgctct acggcatctc gatccagcat atctcctcgt ttcgcgggtt ggggcggctt 5220 tcgctgtacg gcagtagtcg gtgctcgtcc agacgggcca gggtcatgtc tttccacggg 5280 cgcagggtcc tcgtcagcgt agtctgggtc acggtgaagg ggtgcgctcc gggctgcgcg 5340 ctggccaggg tgcgcttgag gctggtcctg ctggtgctga agcgctgccg gtcttcgccc 5400 tgcgcgtcgg ccaggtagca tttgaccatg gtgtcatagt ccagcccctc cgcggcgtgg 5460 cccttggcgc gcagcttgcc cttggaggag gcgccgcacg aggggcagtg cagacttttg 5520 agggcgtaga gcttgggcgc gagaaatacc gattccgggg agtaggcatc cgcgccgcag 5580 gccccgcaga cggtctcgca ttccacgagc caggtgagct ctggccgttc ggggtcaaaa 5640 accaggtttc ccccatgctt tttgatgcgt ttcttacctc tggtttccat gagccggtgt 5700 ccacgctcgg tgacgaaaag gctgtccgtg tccccgtata cagacttgag aggcctgtcc 5760 tcgagcggtg ttccgcggtc ctcctcgtat agaaactcgg accactctga gacaaaggct 5820 cgcgtccagg ccagcacgaa ggaggctaag tgggaggggt agcggtcgtt gtccactagg 5880 gggtccactc gctccagggt gtgaagacac atgtcgccct cttcggcatc aaggaaggtg 5940 attggtttgt aggtgtaggc cacgtgaccg ggtgttcctg aaggggggct ataaaagggg 6000 gtgggggcgc gttcgtcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg 6060 ggtgagtact ccctctgaaa agcgggcatg acttctgcgc taagattgtc agtttccaaa 6120 aacgaggagg atttgatatt cacctggccc gcggtgatgc ctttgagggt ggccgcatcc 6180 atctggtcag aaaagacaat ctttttgttg tcaagcttgg tggcaaacga cccgtagagg 6240 gcgttggaca gcaacttggc gatggagcgc agggtttggt ttttgtcgcg atcggcgcgc 6300 tccttggccg cgatgtttag ctgcacgtat tcgcgcgcaa cgcaccgcca ttcgggaaag 6360 acggtggtgc gctcgtcggg caccaggtgc acgcgccaac cgcggttgtg cagggtgaca 6420 aggtcaacgc tggtggctac ctctccgcgt aggcgctcgt tggtccagca gaggcggccg 6480 cccttgcgcg agcagaatgg cggtaggggg tctagctgcg tctcgtccgg ggggtctgcg 6540 tccacggtaa agaccccggg cagcaggcgc gcgtcgaagt agtctatctt gcatccttgc 6600 aagtctagcg cctgctgcca tgcgcgggcg gcaagcgcgc gctcgtatgg gttgagtggg 6660 ggaccccatg gcatggggtg ggtgagcgcg gaggcgtaca tgccgcaaat gtcgtaaacg 6720 tagaggggct ctctgagtat tccaagatat gtagggtagc atcttccacc gcggatgctg 6780 gcgcgcacgt aatcgtatag ttcgtgcgag ggagcgagga ggtcgggacc gaggttgcta 6840 cgggcgggct gctctgctcg gaagactatc tgcctgaaga tggcatgtga gttggatgat 6900 atggttggac gctggaagac gttgaagctg gcgtctgtga gacctaccgc gtcacgcacg 6960 aaggaggcgt aggagtcgcg cagcttgttg accagctcgg cggtgacctg cacgtctagg 7020 gcgcagtagt ccagggtttc cttgatgatg tcatacttat cctgtccctt ttttttccac 7080 agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt actcttggat cggaaacccg 7140 tcggcctccg aacggtaaga gcctagcatg tagaactggt tgacggcctg gtaggcgcag 7200 catccctttt ctacgggtag cgcgtatgcc tgcgcggcct tccggagcga ggtgtgggtg 7260 agcgcaaagg tgtccctgac catgactttg aggtactggt atttgaagtc agtgtcgtcg 7320 catccgccct gctcccagag caaaaagtcc gtgcgctttt tggaacgcgg atttggcagg 7380 gcgaaggtga catcgttgaa gagtatcttt cccgcgcgag gcataaagtt gcgtgtgatg 7440 cggaagggtc ccggcacctc ggaacggttg ttaattacct gggcggcgag cacgatctcg 7500 tcaaagccgt tgatgttgtg gcccacaatg taaagttcca agaagcgcgg gatgcccttg 7560 atggaaggca attttttaag ttcctcgtag gtgagctctt caggggagct gagcccgtgc 7620 tctgaaaggg cccagtctgc aagatgaggg ttggaagcga cgaatgagct ccacaggtca 7680 cgggccatta gcatttgcag gtggtcgcga aaggtcctaa actggcgacc tatggccatt 7740 ttttctgggg tgatgcagta gaaggtaagc gggtcttgtt cccagcggtc ccatccaagg 7800 ttcgcggcta ggtctcgcgc ggcagtcact agaggctcat ctccgccgaa cttcatgacc 7860 agcatgaagg gcacgagctg cttcccaaag gcccccatcc aagtataggt ctctacatcg 7920 taggtgacaa agagacgctc ggtgcgagga tgcgagccga tcgggaagaa ctggatctcc 7980 cgccaccaat tggaggagtg gctattgatg tggtgaaagt agaagtccct gcgacgggcc 8040 gaacactcgt gctggctttt gtaaaaacgt gcgcagtact ggcagcggtg cacgggctgt 8100 acatcctgca cgaggttgac ctgacgaccg cgcacaagga agcagagtgg gaatttgagc 8160 ccctcgcctg gcgggtttgg ctggtggtct tctacttcgg ctgcttgtcc ttgaccgtct 8220 ggctgctcga ggggagttac ggtggatcgg accaccacgc cgcgcgagcc caaagtccag 8280 atgtccgcgc gcggcggtcg gagcttgatg acaacatcgc gcagatggga gctgtccatg 8340 gtctggagct cccgcggcgt caggtcaggc gggagctcct gcaggtttac ctcgcataga 8400 cgggtcaggg cgcgggctag atccaggtga tacctaattt ccaggggctg gttggtggcg 8460 gcgtcgatgg cttgcaagag gccgcatccc cgcggcgcga ctacggtacc gcgcggcggg 8520 cggtgggccg cgggggtgtc cttggatgat gcatctaaaa gcggtgacgc gggcgagccc 8580 ccggaggtag ggggggctcc ggacccgccg ggagaggggg caggggcacg tcggcgccgc 8640 gcgcgggcag gagctggtgc tgcgcgcgta ggttgctggc gaacgcgacg acgcggcggt 8700 tgatctcctg aatctggcgc ctctgcgtga agacgacggg cccggtgagc ttgagcctga 8760 aagagagttc gacagaatca atttcggtgt cgttgacggc ggcctggcgc aaaatctcct 8820 gcacgtctcc tgagttgtct tgataggcga tctcggccat gaactgctcg atctcttcct 8880 cctggagatc tccgcgtccg gctcgctcca cggtggcggc gaggtcgttg gaaatgcggg 8940 ccatgagctg cgagaaggcg ttgaggcctc cctcgttcca gacgcggctg tagaccacgc 9000 ccccttcggc atcgcgggcg cgcatgacca cctgcgcgag attgagctcc acgtgccggg 9060 cgaagacggc gtagtttcgc aggcgctgaa agaggtagtt gagggtggtg gcggtgtgtt 9120 ctgccacgaa gaagtacata acccagcgtc gcaacgtgga ttcgttgata tcccccaagg 9180 cctcaaggcg ctccatggcc tcgtagaagt ccacggcgaa gttgaaaaac tgggagttgc 9240 gcgccgacac ggttaactcc tcctccagaa gacggatgag ctcggcgaca gtgtcgcgca 9300 cctcgcgctc aaaggctaca ggggcctctt cttcttcttc aatctcctct tccataaggg 9360 cctccccttc ttcttcttct ggcggcggtg ggggaggggg gacacggcgg cgacgacggc 9420 gcaccgggag gcggtcgaca aagcgctcga tcatctcccc gcggcgacgg cgcatggtct 9480 cggtgacggc gcggccgttc tcgcgggggc gcagttggaa gacgccgccc gtcatgtccc 9540 ggttatgggt tggcgggggg ctgccatgcg gcagggatac ggcgctaacg atgcatctca 9600 acaattgttg tgtaggtact ccgccgccga gggacctgag cgagtccgca tcgaccggat 9660 cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc gcaaggtagg ctgagcaccg 9720 tggcgggcgg cagcgggcgg cggtcggggt tgtttctggc ggaggtgctg ctgatgatgt 9780 aattaaagta ggcggtcttg agacggcgga tggtcgacag aagcaccatg tccttgggtc 9840 cggcctgctg aatgcgcagg cggtcggcca tgccccaggc ttcgttttga catcggcgca 9900 ggtctttgta gtagtcttgc atgagccttt ctaccggcac ttcttcttct ccttcctctt 9960 gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga gtttggccgt aggtggcgcc 10020 ctcttcctcc catgcgtgtg accccgaagc ccctcatcgg ctgaagcagg gctaggtcgg 10080 cgacaacgcg ctcggctaat atggcctgct gcacctgcgt gagggtagac tggaagtcat 10140 ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt gtaagtgcag ttggccataa 10200 cggaccagtt aacggtctgg tgacccggct gcgagagctc ggtgtacctg agacgcgagt 10260 aagccctcga gtcaaatacg tagtcgttgc aagtccgcac caggtactgg tatcccacca 10320 aaaagtgcgg cggcggctgg cggtagaggg gccagcgtag ggtggccggg gctccggggg 10380 cgagatcttc caacataagg cgatgatatc cgtagatgta cctggacatc caggtgatgc 10440 cggcggcggt ggtggaggcg cgcggaaagt cgcggacgcg gttccagatg ttgcgcagcg 10500 gcaaaaagtg ctccatggtc gggacgctct ggccggtcag gcgcgcgcaa tcgttgacgc 10560 tctagaccgt gcaaaaggag agcctgtaag cgggcactct tccgtggtct ggtggataaa 10620 ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc cgtatccggc cgtccgccgt 10680 gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg cgacgtcaga caacggggga 10740 gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc gctagctttt ttggccactg 10800 gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc attaagtggc tcgctccctg 10860 tagccggagg gttattttcc aagggttgag tcgcgggacc cccggttcga gtctcggacc 10920 ggccggactg cggcgaacgg gggtttgcct ccccgtcatg caagaccccg cttgcaaatt 10980 cctccggaaa cagggacgag cccctttttt gcttttccca gatgcatccg gtgctgcggc 11040 agatgcgccc ccctcctcag cagcggcaag agcaagagca gcggcagaca tgcagggcac 11100 cctcccctcc tcctaccgcg tcaggagggg cgacatccgc ggttgacgcg gcagcagatg 11160 gtgattacga acccccgcgg cgccgggccc ggcactacct ggacttggag gagggcgagg 11220 gcctggcgcg gctaggagcg ccctctcctg agcggtaccc aagggtgcag ctgaagcgtg 11280 atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg cgaccgcgag ggagaggagc 11340 ccgaggagat gcgggatcga aagttccacg cagggcgcga gctgcggcat ggcctgaatc 11400 gcgagcggtt gctgcgcgag gaggactttg agcccgacgc gcgaaccggg attagtcccg 11460 cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata cgagcagacg gtgaaccagg 11520 agattaactt tcaaaaaagc tttaacaacc acgtgcgtac gcttgtggcg cgcgaggagg 11580 tggctatagg actgatgcat ctgtgggact ttgtaagcgc gctggagcaa aacccaaata 11640 gcaagccgct catggcgcag ctgttcctta tagtgcagca cagcagggac aacgaggcat 11700 tcagggatgc gctgctaaac atagtagagc ccgagggccg ctggctgctc gatttgataa 11760 acatcctgca gagcatagtg gtgcaggagc gcagcttgag cctggctgac aaggtggccg 11820 ccatcaacta ttccatgctt agcctgggca agttttacgc ccgcaagata taccataccc 11880 cttacgttcc catagacaag gaggtaaaga tcgaggggtt ctacatgcgc atggcgctga 11940 aggtgcttac cttgagcgac gacctgggcg tttatcgcaa cgagcgcatc cacaaggccg 12000 tgagcgtgag ccggcggcgc gagctcagcg accgcgagct gatgcacagc ctgcaaaggg 12060 ccctggctgg cacgggcagc ggcgatagag aggccgagtc ctactttgac gcgggcgctg 12120 acctgcgctg ggccccaagc cgacgcgccc tggaggcagc tggggccgga cctgggctgg 12180 cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga ggaatatgac gaggacgatg 12240 agtacgagcc agaggacggc gagtactaag cggtgatgtt tctgatcaga tgatgcaaga 12300 cgcaacggac ccggcggtgc gggcggcgct gcagagccag ccgtccggcc ttaactccac 12360 ggacgactgg cgccaggtca tggaccgcat catgtcgctg actgcgcgca atcctgacgc 12420 gttccggcag cagccgcagg ccaaccggct ctccgcaatt ctggaagcgg tggtcccggc 12480 gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta aacgcgctgg ccgaaaacag 12540 ggccatccgg cccgacgagg ccggcctggt ctacgacgcg ctgcttcagc gcgtggctcg 12600 ttacaacagc ggcaacgtgc agaccaacct ggaccggctg gtgggggatg tgcgcgaggc 12660 cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg ggctccatgg ttgcactaaa 12720 cgccttcctg agtacacagc ccgccaacgt gccgcgggga caggaggact acaccaactt 12780 tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa agtgaggtgt accagtctgg 12840 gccagactat tttttccaga ccagtagaca aggcctgcag accgtaaacc tgagccaggc 12900 tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc acaggcgacc gcgcgaccgt 12960 gtctagcttg ctgacgccca actcgcgcct gttgctgctg ctaatagcgc ccttcacgga 13020 cagtggcagc gtgtcccggg acacatacct aggtcacttg ctgacactgt accgcgaggc 13080 cataggtcag gcgcatgtgg acgagcatac tttccaggag attacaagtg tcagccgcgc 13140 gctggggcag gaggacacgg gcagcctgga ggcaacccta aactacctgc tgaccaaccg 13200 gcggcagaag atcccctcgt tgcacagttt aaacagcgag gaggagcgca ttttgcgcta 13260 cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg gtaacgccca gcgtggcgct 13320 ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc tcaaaccggc cgtttatcaa 13380 ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac cccgagtatt tcaccaatgc 13440 catcttgaac ccgcactggc taccgccccc tggtttctac accgggggat tcgaggtgcc 13500 cgagggtaac gatggattcc tctgggacga catagacgac agcgtgtttt ccccgcaacc 13560 gcagaccctg ctagagttgc aacagcgcga gcaggcagag gcggcgctgc gaaaggaaag 13620 cttccgcagg ccaagcagct tgtccgatct aggcgctgcg gccccgcggt cagatgctag 13680 tagcccattt ccaagcttga tagggtctct taccagcact cgcaccaccc gcccgcgcct 13740 gctgggcgag gaggagtacc taaacaactc gctgctgcag ccgcagcgcg aaaaaaacct 13800 gcctccggca tttcccaaca acgggataga gagcctagtg gacaagatga gtagatggaa 13860 gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc ccgcccaccc gtcgtcaaag 13920 gcacgaccgt cagcggggtc tggtgtggga ggacgatgac tcggcagacg acagcagcgt 13980 cctggatttg ggagggagtg gcaacccgtt tgcgcacctt cgccccaggc tggggagaat 14040 gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc accaaggcca tggcaccgag 14100 cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg cgatgtatga ggaaggtcct 14160 cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg cggcggcgct gggttctccc 14220 ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt acctgcggcc taccgggggg 14280 agaaacagca tccgttactc tgagttggca cccctattcg acaccacccg tgtgtacctg 14340 gtggacaaca agtcaacgga tgtggcatcc ctgaactacc agaacgacca cagcaacttt 14400 ctgaccacgg tcattcaaaa caatgactac agcccggggg aggcaagcac acagaccatc 14460 aatcttgacg accggtcgca ctggggcggc gacctgaaaa ccatcctgca taccaacatg 14520 ccaaatgtga acgagttcat gtttaccaat aagtttaagg cgcgggtgat ggtgtcgcgc 14580 ttgcctacta aggacaatca ggtggagctg aaatacgagt gggtggagtt cacgctgccc 14640 gagggcaact actccgagac catgaccata gaccttatga acaacgcgat cgtggagcac 14700 tacttgaaag tgggcagaca gaacggggtt ctggaaagcg acatcggggt aaagtttgac 14760 acccgcaact tcagactggg gtttgacccc gtcactggtc ttgtcatgcc tggggtatat 14820 acaaacgaag ccttccatcc agacatcatt ttgctgccag gatgcggggt ggacttcacc 14880 cacagccgcc tgagcaactt gttgggcatc cgcaagcggc aacccttcca ggagggcttt 14940 aggatcacct acgatgatct ggagggtggt aacattcccg cactgttgga tgtggacgcc 15000 taccaggcga gcttgaaaga tgacaccgaa cagggcgggg gtggcgcagg cggcagcaac 15060 agcagtggca gcggcgcgga agagaactcc aacgcggcag ccgcggcaat gcagccggtg 15120 gaggacatga acgatcatgc cattcgcggc gacacctttg ccacacgggc tgaggagaag 15180 cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg ctgcgcaacc cgaggtcgag 15240 aagcctcaga agaaaccggt gatcaaaccc ctgacagagg acagcaagaa acgcagttac 15300 aacctaataa gcaatgacag caccttcacc cagtaccgca gctggtacct tgcatacaac 15360 tacggcgacc ctcagaccgg aatccgctca tggaccctgc tttgcactcc tgacgtaacc 15420 tgcggctcgg agcaggtcta ctggtcgttg ccagacatga tgcaagaccc cgtgaccttc 15480 cgctccacgc gccagatcag caactttccg gtggtgggcg ccgagctgtt gcccgtgcac 15540 tccaagagct tctacaacga ccaggccgtc tactcccaac tcatccgcca gtttacctct 15600 ctgacccacg tgttcaatcg ctttcccgag aaccagattt tggcgcgccc gccagccccc 15660 accatcacca ccgtcagtga aaacgttcct gctctcacag atcacgggac gctaccgctg 15720 cgcaacagca tcggaggagt ccagcgagtg accattactg acgccagacg ccgcacctgc 15780 ccctacgttt acaaggccct gggcatagtc tcgccgcgcg tcctatcgag ccgcactttt 15840 tgagcaagca tgtccatcct tatatcgccc agcaataaca caggctgggg cctgcgcttc 15900 ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc aacacccagt gcgcgtgcgc 15960 gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc gcactgggcg caccaccgtc 16020 gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact acacgcccac gccgccacca 16080 gtgtccacag tggacgcggc cattcagacc gtggtgcgcg gagcccggcg ctatgctaaa 16140 atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc gccgacccgg cactgccgcc 16200 caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca ccggccgacg ggcggccatg 16260 cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc cccccaggtc caggcgacga 16320 gcggccgccg cagcagccgc ggccattagt gctatgactc agggtcgcag gggcaacgtg 16380 tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg tgcgcacccg ccccccgcgc 16440 aactagattg caagaaaaaa ctacttagac tcgtactgtt gtatgtatcc agcggcggcg 16500 gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag agatgctcca ggtcatcgcg 16560 ccggagatct atggcccccc gaagaaggaa gagcaggatt acaagccccg aaagctaaag 16620 cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg acgacgaggt ggaactgctg 16680 cacgctaccg cgcccaggcg acgggtacag tggaaaggtc gacgcgtaaa acgtgttttg 16740 cgacccggca ccaccgtagt ctttacgccc ggtgagcgct ccacccgcac ctacaagcgc 16800 gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc aggccaacga gcgcctcggg 16860 gagtttgcct acggaaagcg gcataaggac atgctggcgt tgccgctgga cgagggcaac 16920 ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc tgcccgcgct tgcaccgtcc 16980 gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg cacccaccgt gcagctgatg 17040 gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa tgaccgtgga acctgggctg 17100 gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc cgggactggg cgtgcagacc 17160 gtggacgttc agatacccac taccagtagc accagtattg ccaccgccac agagggcatg 17220 gagacacaaa cgtccccggt tgcctcagcg gtggcggatg ccgcggtgca ggcggtcgct 17280 gcggccgcgt ccaagacctc tacggaggtg caaacggacc cgtggatgtt tcgcgtttca 17340 gccccccggc gcccgcgcgg ttcgaggaag tacggcgccg ccagcgcgct actgcccgaa 17400 tatgccctac atccttccat tgcgcctacc cccggctatc gtggctacac ctaccgcccc 17460 agaagacgag caactacccg acgccgaacc accactggaa cccgccgccg ccgtcgccgt 17520 cgccagcccg tgctggcccc gatttccgtg cgcagggtgg ctcgcgaagg aggcaggacc 17580 ctggtgctgc caacagcgcg ctaccacccc agcatcgttt aaaagccggt ctttgtggtt 17640 cttgcagata tggccctcac ctgccgcctc cgtttcccgg tgccgggatt ccgaggaaga 17700 atgcaccgta ggaggggcat ggccggccac ggcctgacgg gcggcatgcg tcgtgcgcac 17760 caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg gtatcctgcc cctccttatt 17820 ccactgatcg ccgcggcgat tggcgccgtg cccggaattg catccgtggc cttgcaggcg 17880 cagagacact gattaaaaac aagttgcatg tggaaaaatc aaaataaaaa gtctggactc 17940 tcacgctcgc ttggtcctgt aactattttg tagaatggaa gacatcaact ttgcgtctct 18000 ggccccgcga cacggctcgc gcccgttcat gggaaactgg caagatatcg gcaccagcaa 18060 tatgagcggt ggcgccttca gctggggctc gctgtggagc ggcattaaaa atttcggttc 18120 caccgttaag aactatggca gcaaggcctg gaacagcagc acaggccaga tgctgaggga 18180 taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat ggcctggcct ctggcattag 18240 cggggtggtg gacctggcca accaggcagt gcaaaataag attaacagta agcttgatcc 18300 ccgccctccc gtagaggagc ctccaccggc cgtggagaca gtgtctccag aggggcgtgg 18360 cgaaaagcgt ccgcgccccg acagggaaga aactctggtg acgcaaatag acgagcctcc 18420 ctcgtacgag gaggcactaa agcaaggcct gcccaccacc cgtcccatcg cgcccatggc 18480 taccggagtg ctgggccagc acacacccgt aacgctggac ctgcctcccc ccgccgacac 18540 ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt gtaacccgtc ctagccgcgc 18600 gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg cccgtagcca gtggcaactg 18660 gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa tccctgaagc gccgacgatg 18720 cttctgaata gctaacgtgt cgtatgtgtg tcatgtatgc gtccatgtcg ccgccagagg 18780 agctgctgag ccgccgcgcg cccgctttcc aagatggcta ccccttcgat gatgccgcag 18840 tggtcttaca tgcacatctc gggccaggac gcctcggagt acctgagccc cgggctggtg 18900 cagtttgccc gcgccaccga gacgtacttc agcctgaata acaagtttag aaaccccacg 18960 gtggcgccta cgcacgacgt gaccacagac cggtcccagc gtttgacgct gcggttcatc 19020 cctgtggacc gtgaggatac tgcgtactcg tacaaggcgc ggttcaccct agctgtgggt 19080 gataaccgtg tgctggacat ggcttccacg tactttgaca tccgcggcgt gctggacagg 19140 ggccctactt ttaagcccta ctctggcact gcctacaacg ccctggctcc caagggtgcc 19200 ccaaatcctt gcgaatggga tgaagctgct actgctcttg aaataaacct agaagaagag 19260 gacgatgaca acgaagacga agtagacgag caagctgagc agcaaaaaac tcacgtattt 19320 gggcaggcgc cttattctgg tataaatatt acaaaggagg gtattcaaat aggtgtcgaa 19380 ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg aacctcaaat aggagaatct 19440 cagtggtacg aaactgaaat taatcatgca gctgggagag tccttaaaaa gactacccca 19500 atgaaaccat gttacggttc atatgcaaaa cccacaaatg aaaatggagg gcaaggcatt 19560 cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg aaatgcaatt tttctcaact 19620 actgaggcga ccgcaggcaa tggtgataac ttgactccta aagtggtatt gtacagtgaa 19680 gatgtagata tagaaacccc agacactcat atttcttaca tgcccactat taaggaaggt 19740 aactcacgag aactaatggg ccaacaatct atgcccaaca ggcctaatta cattgctttt 19800 agggacaatt ttattggtct aatgtattac aacagcacgg gtaatatggg tgttctggcg 19860 ggccaagcat cgcagttgaa tgctgttgta gatttgcaag acagaaacac agagctttca 19920 taccagcttt tgcttgattc cattggtgat agaaccaggt acttttctat gtggaatcag 19980 gctgttgaca gctatgatcc agatgttaga attattgaaa atcatggaac tgaagatgaa 20040 cttccaaatt actgctttcc actgggaggt gtgattaata cagagactct taccaaggta 20100 aaacctaaaa caggtcagga aaatggatgg gaaaaagatg ctacagaatt ttcagataaa 20160 aatgaaataa gagttggaaa taattttgcc atggaaatca atctaaatgc caacctgtgg 20220 agaaatttcc tgtactccaa catagcgctg tatttgcccg acaagctaaa gtacagtcct 20280 tccaacgtaa aaatttctga taacccaaac acctacgact acatgaacaa gcgagtggtg 20340 gctcccgggt tagtggactg ctacattaac cttggagcac gctggtccct tgactatatg 20400 gacaacgtca acccatttaa ccaccaccgc aatgctggcc tgcgctaccg ctcaatgttg 20460 ctgggcaatg gtcgctatgt gcccttccac atccaggtgc ctcagaagtt ctttgccatt 20520 aaaaacctcc ttctcctgcc gggctcatac acctacgagt ggaacttcag gaaggatgtt 20580 aacatggttc tgcagagctc cctaggaaat gacctaaggg ttgacggagc cagcattaag 20640 tttgatagca tttgccttta cgccaccttc ttccccatgg cccacaacac cgcctccacg 20700 cttgaggcca tgcttagaaa cgacaccaac gaccagtcct ttaacgacta tctctccgcc 20760 gccaacatgc tctaccctat acccgccaac gctaccaacg tgcccatatc catcccctcc 20820 cgcaactggg cggctttccg cggctgggcc ttcacgcgcc ttaagactaa ggaaacccca 20880 tcactgggct cgggctacga cccttattac acctactctg gctctatacc ctacctagat 20940 ggaacctttt acctcaacca cacctttaag aaggtggcca ttacctttga ctcttctgtc 21000 agctggcctg gcaatgaccg cctgcttacc cccaacgagt ttgaaattaa gcgctcagtt 21060 gacggggagg gttacaacgt tgcccagtgt aacatgacca aagactggtt cctggtacaa 21120 atgctagcta actacaacat tggctaccag ggcttctata tcccagagag ctacaaggac 21180 cgcatgtact ccttctttag aaacttccag cccatgagcc gtcaggtggt ggatgatact 21240 aaatacaagg actaccaaca ggtgggcatc ctacaccaac acaacaactc tggatttgtt 21300 ggctaccttg cccccaccat gcgcgaagga caggcctacc ctgctaactt cccctatccg 21360 cttataggca agaccgcagt tgacagcatt acccagaaaa agtttctttg cgatcgcacc 21420 ctttggcgca tcccattctc cagtaacttt atgtccatgg gcgcactcac agacctgggc 21480 caaaaccttc tctacgccaa ctccgcccac gcgctagaca tgacttttga ggtggatccc 21540 atggacgagc ccacccttct ttatgttttg tttgaagtct ttgacgtggt ccgtgtgcac 21600 cggccgcacc gcggcgtcat cgaaaccgtg tacctgcgca cgcccttctc ggccggcaac 21660 gccacaacat aaagaagcaa gcaacatcaa caacagctgc cgccatgggc tccagtgagc 21720 aggaactgaa agccattgtc aaagatcttg gttgtgggcc atattttttg ggcacctatg 21780 acaagcgctt tccaggcttt gtttctccac acaagctcgc ctgcgccata gtcaatacgg 21840 ccggtcgcga gactgggggc gtacactgga tggcctttgc ctggaacccg cactcaaaaa 21900 catgctacct ctttgagccc tttggctttt ctgaccagcg actcaagcag gtttaccagt 21960 ttgagtacga gtcactcctg cgccgtagcg ccattgcttc ttcccccgac cgctgtataa 22020 cgctggaaaa gtccacccaa agcgtacagg ggcccaactc ggccgcctgt ggactattct 22080 gctgcatgtt tctccacgcc tttgccaact ggccccaaac tcccatggat cacaacccca 22140 ccatgaacct tattaccggg gtacccaact ccatgctcaa cagtccccag gtacagccca 22200 ccctgcgtcg caaccaggaa cagctctaca gcttcctgga gcgccactcg ccctacttcc 22260 gcagccacag tgcgcagatt aggagcgcca cttctttttg tcacttgaaa aacatgtaaa 22320 aataatgtac tagagacact ttcaataaag gcaaatgctt ttatttgtac actctcgggt 22380 gattatttac ccccaccctt gccgtctgcg ccgtttaaaa atcaaagggg ttctgccgcg 22440 catcgctatg cgccactggc agggacacgt tgcgatactg gtgtttagtg ctccacttaa 22500 actcaggcac aaccatccgc ggcagctcgg tgaagttttc actccacagg ctgcgcacca 22560 tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa gtcgcagttg gggcctccgc 22620 cctgcgcgcg cgagttgcga tacacagggt tgcagcactg gaacactatc agcgccgggt 22680 ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc cgcgtccagg tcctccgcgt 22740 tgctcagggc gaacggagtc aactttggta gctgccttcc caaaaagggc gcgtgcccag 22800 gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg accgtgcccg gtctgggcgt 22860 taggatacag cgcctgcata aaagccttga tctgcttaaa agccacctga gcctttgcgc 22920 cttcagagaa gaacatgccg caagacttgc cggaaaactg attggccgga caggccgcgt 22980 cgtgcacgca gcaccttgcg tcggtgttgg agatctgcac cacatttcgg ccccaccggt 23040 tcttcacgat cttggccttg ctagactgct ccttcagcgc gcgctgcccg ttttcgctcg 23100 tcacatccat ttcaatcacg tgctccttat ttatcataat gcttccgtgt agacacttaa 23160 gctcgccttc gatctcagcg cagcggtgca gccacaacgc gcagcccgtg ggctcgtgat 23220 gcttgtaggt cacctctgca aacgactgca ggtacgcctg caggaatcgc cccatcatcg 23280 tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc gcggtgctcc tcgttcagcc 23340 aggtcttgca tacggccgcc agagcttcca cttggtcagg cagtagtttg aagttcgcct 23400 ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg cgcagcctcc atgcccttct 23460 cccacgcaga cacgatcggc acactcagcg ggttcatcac cgtaatttca ctttccgctt 23520 cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg cgccactggg tcgtcttcat 23580 tcagccgccg cactgtgcgc ttacctcctt tgccatgctt gattagcacc ggtgggttgc 23640 tgaaacccac catttgtagc gccacatctt ctctttcttc ctcgctgtcc acgattacct 23700 ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt ctttttcttc ttgggcgcaa 23760 tggccaaatc cgccgccgag gtcgatggcc gcgggctggg tgtgcgcggc accagcgcgt 23820 cttgtgatga gtcttcctcg tcctcggact cgatacgccg cctcatccgc ttttttgggg 23880 gcgcccgggg aggcggcggc gacggggacg gggacgacac gtcctccatg gttgggggac 23940 gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg ctgctcctct tcccgactgg 24000 ccatttcctt ctcctatagg cagaaaaaga tcatggagtc agtcgagaag aaggacagcc 24060 taaccgcccc ctctgagttc gccaccaccg cctccaccga tgccgccaac gcgcctacca 24120 ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt gattatcgag caggacccag 24180 gttttgtaag cgaagacgac gaggaccgct cagtaccaac agaggataaa aagcaagacc 24240 aggacaacgc agaggcaaac gaggaacaag tcgggcgggg ggacgaaagg catggcgact 24300 acctagatgt gggagacgac gtgctgttga agcatctgca gcgccagtgc gccattatct 24360 gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat agcggatgtc agccttgcct 24420 acgaacgcca cctattctca ccgcgcgtac cccccaaacg ccaagaaaac ggcacatgcg 24480 agcccaaccc gcgcctcaac ttctaccccg tatttgccgt gccagaggtg cttgccacct 24540 atcacatctt tttccaaaac tgcaagatac ccctatcctg ccgtgccaac cgcagccgag 24600 cggacaagca gctggccttg cggcagggcg ctgtcatacc tgatatcgcc tcgctcaacg 24660 aagtgccaaa aatctttgag ggtcttggac gcgacgagaa gcgcgcggca aacgctctgc 24720 aacaggaaaa cagcgaaaat gaaagtcact ctggagtgtt ggtggaactc gagggtgaca 24780 acgcgcgcct agccgtacta aaacgcagca tcgaggtcac ccactttgcc tacccggcac 24840 ttaacctacc ccccaaggtc atgagcacag tcatgagtga gctgatcgtg cgccgtgcgc 24900 agcccctgga gagggatgca aatttgcaag aacaaacaga ggagggccta cccgcagttg 24960 gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc tgccgacttg gaggagcgac 25020 gcaaactaat gatggccgca gtgctcgtta ccgtggagct tgagtgcatg cagcggttct 25080 ttgctgaccc ggagatgcag cgcaagctag aggaaacatt gcactacacc tttcgacagg 25140 gctacgtacg ccaggcctgc aagatctcca acgtggagct ctgcaacctg gtctcctacc 25200 ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct tcattccacg ctcaagggcg 25260 aggcgcgccg cgactacgtc cgcgactgcg tttacttatt tctatgctac acctggcaga 25320 cggccatggg cgtttggcag cagtgcttgg aggagtgcaa cctcaaggag ctgcagaaac 25380 tgctaaagca aaacttgaag gacctatgga cggccttcaa cgagcgctcc gtggccgcgc 25440 acctggcgga catcattttc cccgaacgcc tgcttaaaac cctgcaacag ggtctgccag 25500 acttcaccag tcaaagcatg ttgcagaact ttaggaactt tatcctagag cgctcaggaa 25560 tcttgcccgc cacctgctgt gcacttccta gcgactttgt gcccattaag taccgcgaat 25620 gccctccgcc gctttggggc cactgctacc ttctgcagct agccaactac cttgcctacc 25680 actctgacat aatggaagac gtgagcggtg acggtctact ggagtgtcac tgtcgctgca 25740 acctatgcac cccgcaccgc tccctggttt gcaattcgca gctgcttaac gaaagtcaaa 25800 ttatcggtac ctttgagctg cagggtccct cgcctgacga aaagtccgcg gctccggggt 25860 tgaaactcac tccggggctg tggacgtcgg cttaccttcg caaatttgta cctgaggact 25920 accacgccca cgagattagg ttctacgaag accaatcccg cccgccaaat gcggagctta 25980 ccgcctgcgt cattacccag ggccacattc ttggccaatt gcaagccatc aacaaagccc 26040 gccaagagtt tctgctacga aagggacggg gggtttactt ggacccccag tccggcgagg 26100 agctcaaccc aatccccccg ccgccgcagc cctatcagca gcagccgcgg gcccttgctt 26160 cccaggatgg cacccaaaaa gaagctgcag ctgccgccgc cacccacgga cgaggaggaa 26220 tactgggaca gtcaggcaga ggaggttttg gacgaggagg aggaggacat gatggaagac 26280 tgggagagcc tagacgagga agcttccgag gtcgaagagg tgtcagacga aacaccgtca 26340 ccctcggtcg cattcccctc gccggcgccc cagaaatcgg caaccggttc cagcatggct 26400 acaacctccg ctcctcaggc gccgccggca ctgcccgttc gccgacccaa ccgtagatgg 26460 gacaccactg gaaccagggc cggtaagtcc aagcagccgc cgccgttagc ccaagagcaa 26520 caacagcgcc aaggctaccg ctcatggcgc gggcacaaga acgccatagt tgcttgcttg 26580 caagactgtg ggggcaacat ctccttcgcc cgccgctttc ttctctacca tcacggcgtg 26640 gccttccccc gtaacatcct gcattactac cgtcatctct acagcccata ctgcaccggc 26700 ggcagcggca gcggcagcaa cagcagcggc cacacagaag caaaggcgac cggatagcaa 26760 gactctgaca aagcccaaga aatccacagc ggcggcagca gcaggaggag gagcgctgcg 26820 tctggcgccc aacgaacccg tatcgacccg cgagcttaga aacaggattt ttcccactct 26880 gtatgctata tttcaacaga gcaggggcca agaacaagag ctgaaaataa aaaacaggtc 26940 tctgcgatcc ctcacccgca gctgcctgta tcacaaaagc gaagatcagc ttcggcgcac 27000 gctggaagac gcggaggctc tcttcagtaa atactgcgcg ctgactctta aggactagtt 27060 tcgcgccctt tctcaaattt aagcgcgaaa actacgtcat ctccagcggc cacacccggc 27120 gccagcacct gtcgtcagcg ccatttatga gcaaggaaat tcccacgccc tacatgtgga 27180 gttaccagcc acaaatggga cttgcggctg gagctgccca agactactca acccgaataa 27240 actacatgag cgcgggaccc cacatgatat cccgggtcaa cggaatacgc gcccaccgaa 27300 accgaattct cctggaacag gcggctatta ccaccacacc tcgtaataac cttaatcccc 27360 gtagttggcc cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc 27420 ccagagacgc ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct 27480 ttcgtcacag ggtgcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag 27540 gtattcagct caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat 27600 ttcagatcgg cggcgccggc cgctcttcat tcacgcctcg tcaggcaatc ctaactctgc 27660 agacctcgtc ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt 27720 ttgtgccatc ggtctacttt aaccccttct cgggacctcc cggccactat ccggatcaat 27780 ttattcctaa ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg 27840 gagaggcaga gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg 27900 cccgcgactc cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg 27960 cgcacggcgt ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta 28020 cccagcgccc cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca 28080 actgtcctaa ccctggatta catcaagatc tttgttgcca tctctgtgct gagtataata 28140 aatacagaaa ttaaaatata ctggggctcc tatcgccatc ctgtaaacgc caccgtcttc 28200 acccgcccaa gcaaaccaag gcgaacctta cctggtactt ttaacatctc tccctctgtg 28260 atttacaaca gtttcaaccc agacggagtg agtctacgag agaacctctc cgagctcagc 28320 tactccatca gaaaaaacac caccctcctt acctgccggg aacgtacgag tgcgtcaccg 28380 gccgctgcac cacacctacc gcctgaccgt aaaccagact ttttccggac agacctcaat 28440 aactctgttt accagaacag gaggtgagct tagaaaaccc ttagggtatt aggccaaagg 28500 cgcagctact gtggggttta tgaacaattc aagcaactct acgggctatt ctaattcagg 28560 tttctctaga atcggggttg gggttattct ctgtcttgtg attctcttta ttcttatact 28620 aacgcttctc tgcctaaggc tcgccgcctg ctgtgtgcac atttgcattt attgtcagct 28680 ttttaaacgc tggggtcgcc acccaagatg attaggtaca taatcctagg tttactcacc 28740 cttgcgtcag cccacggtac cacccaaaag gtggatttta aggagccagc ctgtaatgtt 28800 acattcgcag ctgaagctaa tgagtgcacc actcttataa aatgcaccac agaacatgaa 28860 aagctgctta ttcgccacaa aaacaaaatt ggcaagtatg ctgtttatgc tatttggcag 28920 ccaggtgaca ctacagagta taatgttaca gttttccagg gtaaaagtca taaaactttt 28980 atgtatactt ttccatttta tgaaatgtgc gacattacca tgtacatgag caaacagtat 29040 aagttgtggc ccccacaaaa ttgtgtggaa aacactggca ctttctgctg cactgctatg 29100 ctaattacag tgctcgcttt ggtctgtacc ctactctata ttaaatacaa aagcagacgc 29160 agctttattg aggaaaagaa aatgccttaa tttactaagt tacaaagcta atgtcaccac 29220 taactgcttt actcgctgct tgcaaaacaa attcaaaaag ttagcattat aattagaata 29280 ggatttaaac cccccggtca tttcctgctc aataccattc ccctgaacaa ttgactctat 29340 gtgggatatg ctccagcgct acaaccttga agtcaggctt cctggatgtc agcatctgac 29400 tttggccagc acctgtcccg cggatttgtt ccagtccaac tacagcgacc caccctaaca 29460 gagatgacca acacaaccaa cgcggccgcc gctaccggac ttacatctac cacaaataca 29520 ccccaagttt ctgcctttgt caataactgg gataacttgg gcatgtggtg gttctccata 29580 gcgcttatgt ttgtatgcct tattattatg tggctcatct gctgcctaaa gcgcaaacgc 29640 gcccgaccac ccatctatag tcccatcatt gtgctacacc caaacaatga tggaatccat 29700 agattggacg gactgaaaca catgttcttt tctcttacag tatgattaaa tgagacatga 29760 ttcctcgagt ttttatatta ctgacccttg ttgcgctttt ttgtgcgtgc tccacattgg 29820 ctgcggtttc tcacatcgaa gtagactgca ttccagcctt cacagtctat ttgctttacg 29880 gatttgtcac cctcacgctc atctgcagcc tcatcactgt ggtcatcgcc tttatccagt 29940 gcattgactg ggtctgtgtg cgctttgcat atctcagaca ccatccccag tacagggaca 30000 ggactatagc tgagcttctt agaattcttt aattatgaaa tttactgtga cttttctgct 30060 gattatttgc accctatctg cgttttgttc cccgacctcc aagcctcaaa gacatatatc 30120 atgcagattc actcgtatat ggaatattcc aagttgctac aatgaaaaaa gcgatctttc 30180 cgaagcctgg ttatatgcaa tcatctctgt tatggtgttc tgcagtacca tcttagccct 30240 agctatatat ccctaccttg acattggctg gaacgcaata gatgccatga accacccaac 30300 tttccccgcg cccgctatgc ttccactgca acaagttgtt gccggcggct ttgtcccagc 30360 caatcagcct cgcccacctt ctcccacccc cactgaaatc agctacttta atctaacagg 30420 aggagatgac tgacacccta gatctagaaa tggacggaat tattacagag cagcgcctgc 30480 tagaaagacg cagggcagcg gccgagcaac agcgcatgaa tcaagagctc caagacatgg 30540 ttaacttgca ccagtgcaaa aggggtatct tttgtctggt aaagcaggcc aaagtcacct 30600 acgacagtaa taccaccgga caccgcctta gctacaagtt gccaaccaag cgtcagaaat 30660 tggtggtcat ggtgggagaa aagcccatta ccataactca gcactcggta gaaaccgaag 30720 gctgcattca ctcaccttgt caaggacctg aggatctctg cacccttatt aagaccctgt 30780 gcggtctcaa agatcttatt ccctttaact aataaaaaaa aataataaag catcacttac 30840 ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc 30900 cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg 30960 tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag 31020 cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt 31080 cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt 31140 ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt 31200 gcgctcaaaa tgggcaacgg cctctctctg gacgaggccg gcaaccttac ctcccaaaat 31260 gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct 31320 gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc 31380 gcgggcaaca cactcaccat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt 31440 agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca 31500 ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact 31560 actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa 31620 ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac tttgaccgta 31680 gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc 31740 ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat 31800 tctcaaaaca gacgccttat acttgatgtt agttatccgt ttgatgctca aaaccaacta 31860 aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac 31920 tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac 31980 ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat 32040 gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc 32100 catggcctag aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt 32160 tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg 32220 accacaccag ctccatctcc taactgtaga ctaaatgcag agaaagatgc taaactcact 32280 ttggtcttaa caaaatgtgg cagtcaaata cttgctacag tttcagtttt ggctgttaaa 32340 ggcagtttgg ctccaatatc tggaacagtt caaagtgctc atcttattat aagatttgac 32400 gaaaatggag tgctactaaa caattccttc ctggacccag aatattggaa ctttagaaat 32460 ggagatctta ctgaaggcac agcctataca aacgctgttg gatttatgcc taacctatca 32520 gcttatccaa aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca agtttactta 32580 aacggagaca aaactaaacc tgtaacacta accattacac taaacggtac acaggaaaca 32640 ggagacacaa ctccaagtgc atactctatg tcattttcat gggactggtc tggccacaac 32700 tacattaatg aaatatttgc cacatcctct tacacttttt catacattgc ccaagaataa 32760 agaatcgttt gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcgaatca 32820 tttttcattc agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa 32880 tcaaacctac atgggggtag agtcataatc gtgcatcagg atagggcggt ggtgctgcag 32940 cagcgcgcga ataaactgct gccgccgccg ctccgtcctg caggaataca acatggcagt 33000 ggtctcctca gcgatgattc gcaccgcccg cagcataagg cgccttgtcc tccgggcaca 33060 gcagcgcacc ctgatctcac ttaaatcagc acagtaactg cagcacagca ccacaatatt 33120 gttcaaaatc ccacagtgca aggcgctgta tccaaagctc atggcgggga ccacagaacc 33180 cacgtggcca tcataccaca agcgcaggta gattaagtgg cgacccctca taaacacgct 33240 ggacataaac attacctctt ttggcatgtt gtaattcacc acctcccggt accatataaa 33300 cctctgatta aacatggcgc catccaccac catcctaaac cagctggcca aaacctgccc 33360 gccggctata cactgcaggg aaccgggact ggaacaatga cagtggagag cccaggactc 33420 gtaaccatgg atcatcatgc tcgtcatgat atcaatgttg gcacaacaca ggcacacgtg 33480 catacacttc ctcaggatta caagctcctc ccgcgttaga accatatccc agggaacaac 33540 ccattcctga atcagcgtaa atcccacact gcagggaaga cctcgcacgt aactcacgtt 33600 gtgcattgtc aaagtgttac attcgggcag cagcggatga tcctccagta tggtagcgcg 33660 ggtttctgtc tcaaaaggag gtagacgatc cctactgtac ggagtgcgcc gagacaaccg 33720 agatcgtgtt ggtcgtagtg tcatgccaaa tggaacgccg gacgtagtca tatttcctga 33780 agcaaaacca ggtgcgggcg tgacaaacag atctgcgtct ccggtctcgc cgcttagatc 33840 gctctgtgta gtagttgtag tatatccact ctctcaaagc atccaggcgc cccctggctt 33900 cgggttctat gtaaactcct tcatgcgccg ctgccctgat aacatccacc accgcagaat 33960 aagccacacc cagccaacct acacattcgt tctgcgagtc acacacggga ggagcgggaa 34020 gagctggaag aaccatgttt ttttttttat tccaaaagat tatccaaaac ctcaaaatga 34080 agatctatta agtgaacgcg ctcccctccg gtggcgtggt caaactctac agccaaagaa 34140 cagataatgg catttgtaag atgttgcaca atggcttcca aaaggcaaac ggccctcacg 34200 tccaagtgga cgtaaaggct aaacccttca gggtgaatct cctctataaa cattccagca 34260 ccttcaacca tgcccaaata attctcatct cgccaccttc tcaatatatc tctaagcaaa 34320 tcccgaatat taagtccggc cattgtaaaa atctgctcca gagcgccctc caccttcagc 34380 ctcaagcagc gaatcatgat tgcaaaaatt caggttcctc acagacctgt ataagattca 34440 aaagcggaac attaacaaaa ataccgcgat cccgtaggtc ccttcgcagg gccagctgaa 34500 cataatcgtg caggtctgca cggaccagcg cggccacttc cccgccagga accatgacaa 34560 aagaacccac actgattatg acacgcatac tcggagctat gctaaccagc gtagccccga 34620 tgtaagcttg ttgcatgggc ggcgatataa aatgcaaggt gctgctcaaa aaatcaggca 34680 aagcctcgcg caaaaaagaa agcacatcgt agtcatgctc atgcagataa aggcaggtaa 34740 gctccggaac caccacagaa aaagacacca tttttctctc aaacataaca gtcagcctta 34800 ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac acggcaccag ctcaatcagt 34860 cacagtgtaa aaaagggcca agtgcagagc gagtatatat aggactaaaa aatgacgtaa 34920 cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg aacctacgcc cagaaacgaa 34980 agccaaaaaa cccacaactt cctcaaatcg tcacttccgt tttcccacgt tacgtcactt 35040 cccattttaa gaaaactaca attcccaaca catacaagtt actccgccct aaaacctacg 35100 tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac tccaccccct cattatcata 35160 ttggcttcaa tccaaaataa ggtatattat tgatgatg 35198 <210> 25 <211> 35578 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO312) <400> 25 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagca taagtgtctt gctgtcttta 4080 tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct 4140 gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag 4200 cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta 4260 gatgatccag tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa 4320 gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg 4380 gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc 4440 agccatatcc ctccggggat tcatgttgtg cagaaccacc agcacagtgt atccggtgca 4500 cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt 4560 gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc 4620 ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc 4680 gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcggta taatggttcc 4740 atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga 4800 tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg taggggagat 4860 cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta 4920 aatcacacct attaccgggt gcaactggta gttaagagag ctgcagctgc cgtcatccct 4980 gagcaggggg gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc 5040 cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa 5100 cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg 5160 gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc 5220 gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc 5280 atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc 5340 gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc 5400 tgccggtctt cgccctgcgc gtcggccagg tagcatttga ccatggtgtc atagtccagc 5460 ccctccgcgg cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg 5520 cagtgcagac ttttgagggc gtagagcttg ggcgcgagaa ataccgattc cggggagtag 5580 gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc 5640 cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt 5700 tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac 5760 ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac 5820 tctgagacaa aggctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg 5880 tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg 5940 gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg 6000 gggctataaa agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg 6060 agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga 6120 ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg 6180 agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca 6240 aacgacccgt agagggcgtt ggacagcaac ttggcgatgg agcgcagggt ttggtttttg 6300 tcgcgatcgg cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac 6360 cgccattcgg gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg 6420 ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc 6480 cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg 6540 tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct 6600 atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg 6660 tatgggttga gtgggggacc ccatggcatg gggtgggtga gcgcggaggc gtacatgccg 6720 caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt 6780 ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg 6840 ggaccgaggt tgctacgggc gggctgctct gctcggaaga ctatctgcct gaagatggca 6900 tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct 6960 accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg 7020 acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt 7080 cccttttttt tccacagctc gcggttgagg acaaactctt cgcggtcttt ccagtactct 7140 tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg 7200 gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg 7260 agcgaggtgt gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg 7320 aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa 7380 cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata 7440 aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg 7500 gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag ttccaagaag 7560 cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg 7620 gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat 7680 gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg 7740 cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag 7800 cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg 7860 ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta 7920 taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg 7980 aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag 8040 tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag 8100 cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag 8160 agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct 8220 tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc 8280 gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga 8340 tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg 8400 tttacctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg 8460 ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg 8520 gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt 8580 gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg 8640 gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg 8700 cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg 8760 tgagcttgag cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct 8820 ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact 8880 gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt 8940 cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc 9000 ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga 9060 gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg 9120 tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt 9180 tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga 9240 aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg 9300 cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct 9360 cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac 9420 ggcggcgacg acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc 9480 gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc 9540 cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc 9600 taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt 9660 ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 9720 gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg 9780 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca 9840 ccatgtcctt gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt 9900 tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt 9960 cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg 10020 gccgtaggtg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa 10080 gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg 10140 tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag 10200 tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt 10260 acctgagacg cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt 10320 actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg 10380 ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg 10440 acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc 10500 agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg gtcaggcgcg 10560 cgcaatcgtt gacgctctag accgtgcaaa aggagagcct gtaagcgggc actcttccgt 10620 ggtctggtgg ataaattcgc aagggtatca tggcggacga ccggggttcg agccccgtat 10680 ccggccgtcc gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg 10740 tcagacaacg ggggagtgct ccttttggct tccttccagg cgcggcggct gctgcgctag 10800 cttttttggc cactggccgc gcgcagcgta agcggttagg ctggaaagcg aaagcattaa 10860 gtggctcgct ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg ggacccccgg 10920 ttcgagtctc ggaccggccg gactgcggcg aacgggggtt tgcctccccg tcatgcaaga 10980 ccccgcttgc aaattcctcc ggaaacaggg acgagcccct tttttgcttt tcccagatgc 11040 atccggtgct gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc 11100 agacatgcag ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca tccgcggttg 11160 acgcggcagc agatggtgat tacgaacccc cgcggcgccg ggcccggcac tacctggact 11220 tggaggaggg cgagggcctg gcgcggctag gagcgccctc tcctgagcgg tacccaaggg 11280 tgcagctgaa gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc 11340 gcgagggaga ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc 11400 ggcatggcct gaatcgcgag cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa 11460 ccgggattag tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc gcatacgagc 11520 agacggtgaa ccaggagatt aactttcaaa aaagctttaa caaccacgtg cgtacgcttg 11580 tggcgcgcga ggaggtggct ataggactga tgcatctgtg ggactttgta agcgcgctgg 11640 agcaaaaccc aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg cagcacagca 11700 gggacaacga ggcattcagg gatgcgctgc taaacatagt agagcccgag ggccgctggc 11760 tgctcgattt gataaacatc ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg 11820 ctgacaaggt ggccgccatc aactattcca tgcttagcct gggcaagttt tacgcccgca 11880 agatatacca taccccttac gttcccatag acaaggaggt aaagatcgag gggttctaca 11940 tgcgcatggc gctgaaggtg cttaccttga gcgacgacct gggcgtttat cgcaacgagc 12000 gcatccacaa ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc 12060 acagcctgca aagggccctg gctggcacgg gcagcggcga tagagaggcc gagtcctact 12120 ttgacgcggg cgctgacctg cgctgggccc caagccgacg cgccctggag gcagctgggg 12180 ccggacctgg gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat 12240 atgacgagga cgatgagtac gagccagagg acggcgagta ctaagcggtg atgtttctga 12300 tcagatgatg caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc 12360 cggccttaac tccacggacg actggcgcca ggtcatggac cgcatcatgt cgctgactgc 12420 gcgcaatcct gacgcgttcc ggcagcagcc gcaggccaac cggctctccg caattctgga 12480 agcggtggtc ccggcgcgcg caaaccccac gcacgagaag gtgctggcga tcgtaaacgc 12540 gctggccgaa aacagggcca tccggcccga cgaggccggc ctggtctacg acgcgctgct 12600 tcagcgcgtg gctcgttaca acagcggcaa cgtgcagacc aacctggacc ggctggtggg 12660 ggatgtgcgc gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca acctgggctc 12720 catggttgca ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc ggggacagga 12780 ggactacacc aactttgtga gcgcactgcg gctaatggtg actgagacac cgcaaagtga 12840 ggtgtaccag tctgggccag actatttttt ccagaccagt agacaaggcc tgcagaccgt 12900 aaacctgagc caggctttca aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg 12960 cgaccgcgcg accgtgtcta gcttgctgac gcccaactcg cgcctgttgc tgctgctaat 13020 agcgcccttc acggacagtg gcagcgtgtc ccgggacaca tacctaggtc acttgctgac 13080 actgtaccgc gaggccatag gtcaggcgca tgtggacgag catactttcc aggagattac 13140 aagtgtcagc cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa ccctaaacta 13200 cctgctgacc aaccggcggc agaagatccc ctcgttgcac agtttaaaca gcgaggagga 13260 gcgcattttg cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg acggggtaac 13320 gcccagcgtg gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa 13380 ccggccgttt atcaaccgcc taatggacta cttgcatcgc gcggccgccg tgaaccccga 13440 gtatttcacc aatgccatct tgaacccgca ctggctaccg ccccctggtt tctacaccgg 13500 gggattcgag gtgcccgagg gtaacgatgg attcctctgg gacgacatag acgacagcgt 13560 gttttccccg caaccgcaga ccctgctaga gttgcaacag cgcgagcagg cagaggcggc 13620 gctgcgaaag gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc 13680 gcggtcagat gctagtagcc catttccaag cttgataggg tctcttacca gcactcgcac 13740 cacccgcccg cgcctgctgg gcgaggagga gtacctaaac aactcgctgc tgcagccgca 13800 gcgcgaaaaa aacctgcctc cggcatttcc caacaacggg atagagagcc tagtggacaa 13860 gatgagtaga tggaagacgt acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc 13920 cacccgtcgt caaaggcacg accgtcagcg gggtctggtg tgggaggacg atgactcggc 13980 agacgacagc agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc accttcgccc 14040 caggctgggg agaatgtttt aaaaaaaaaa aagcatgatg caaaataaaa aactcaccaa 14100 ggccatggca ccgagcgttg gttttcttgt attcccctta gtatgcggcg cgcggcgatg 14160 tatgaggaag gtcctcctcc ctcctacgag agtgtggtga gcgcggcgcc agtggcggcg 14220 gcgctgggtt ctcccttcga tgctcccctg gacccgccgt ttgtgcctcc gcggtacctg 14280 cggcctaccg gggggagaaa cagcatccgt tactctgagt tggcacccct attcgacacc 14340 acccgtgtgt acctggtgga caacaagtca acggatgtgg catccctgaa ctaccagaac 14400 gaccacagca actttctgac cacggtcatt caaaacaatg actacagccc gggggaggca 14460 agcacacaga ccatcaatct tgacgaccgg tcgcactggg gcggcgacct gaaaaccatc 14520 ctgcatacca acatgccaaa tgtgaacgag ttcatgttta ccaataagtt taaggcgcgg 14580 gtgatggtgt cgcgcttgcc tactaaggac aatcaggtgg agctgaaata cgagtgggtg 14640 gagttcacgc tgcccgaggg caactactcc gagaccatga ccatagacct tatgaacaac 14700 gcgatcgtgg agcactactt gaaagtgggc agacagaacg gggttctgga aagcgacatc 14760 ggggtaaagt ttgacacccg caacttcaga ctggggtttg accccgtcac tggtcttgtc 14820 atgcctgggg tatatacaaa cgaagccttc catccagaca tcattttgct gccaggatgc 14880 ggggtggact tcacccacag ccgcctgagc aacttgttgg gcatccgcaa gcggcaaccc 14940 ttccaggagg gctttaggat cacctacgat gatctggagg gtggtaacat tcccgcactg 15000 ttggatgtgg acgcctacca ggcgagcttg aaagatgaca ccgaacaggg cgggggtggc 15060 gcaggcggca gcaacagcag tggcagcggc gcggaagaga actccaacgc ggcagccgcg 15120 gcaatgcagc cggtggagga catgaacgat catgccattc gcggcgacac ctttgccaca 15180 cgggctgagg agaagcgcgc tgaggccgaa gcagcggccg aagctgccgc ccccgctgcg 15240 caacccgagg tcgagaagcc tcagaagaaa ccggtgatca aacccctgac agaggacagc 15300 aagaaacgca gttacaacct aataagcaat gacagcacct tcacccagta ccgcagctgg 15360 taccttgcat acaactacgg cgaccctcag accggaatcc gctcatggac cctgctttgc 15420 actcctgacg taacctgcgg ctcggagcag gtctactggt cgttgccaga catgatgcaa 15480 gaccccgtga ccttccgctc cacgcgccag atcagcaact ttccggtggt gggcgccgag 15540 ctgttgcccg tgcactccaa gagcttctac aacgaccagg ccgtctactc ccaactcatc 15600 cgccagttta cctctctgac ccacgtgttc aatcgctttc ccgagaacca gattttggcg 15660 cgcccgccag cccccaccat caccaccgtc agtgaaaacg ttcctgctct cacagatcac 15720 gggacgctac cgctgcgcaa cagcatcgga ggagtccagc gagtgaccat tactgacgcc 15780 agacgccgca cctgccccta cgtttacaag gccctgggca tagtctcgcc gcgcgtccta 15840 tcgagccgca ctttttgagc aagcatgtcc atccttatat cgcccagcaa taacacaggc 15900 tggggcctgc gcttcccaag caagatgttt ggcggggcca agaagcgctc cgaccaacac 15960 ccagtgcgcg tgcgcgggca ctaccgcgcg ccctggggcg cgcacaaacg cggccgcact 16020 gggcgcacca ccgtcgatga cgccatcgac gcggtggtgg aggaggcgcg caactacacg 16080 cccacgccgc caccagtgtc cacagtggac gcggccattc agaccgtggt gcgcggagcc 16140 cggcgctatg ctaaaatgaa gagacggcgg aggcgcgtag cacgtcgcca ccgccgccga 16200 cccggcactg ccgcccaacg cgcggcggcg gccctgctta accgcgcacg tcgcaccggc 16260 cgacgggcgg ccatgcgggc cgctcgaagg ctggccgcgg gtattgtcac tgtgcccccc 16320 aggtccaggc gacgagcggc cgccgcagca gccgcggcca ttagtgctat gactcagggt 16380 cgcaggggca acgtgtattg ggtgcgcgac tcggttagcg gcctgcgcgt gcccgtgcgc 16440 acccgccccc cgcgcaacta gattgcaaga aaaaactact tagactcgta ctgttgtatg 16500 tatccagcgg cggcggcgcg caacgaagct atgtccaagc gcaaaatcaa agaagagatg 16560 ctccaggtca tcgcgccgga gatctatggc cccccgaaga aggaagagca ggattacaag 16620 ccccgaaagc taaagcgggt caaaaagaaa aagaaagatg atgatgatga acttgacgac 16680 gaggtggaac tgctgcacgc taccgcgccc aggcgacggg tacagtggaa aggtcgacgc 16740 gtaaaacgtg ttttgcgacc cggcaccacc gtagtcttta cgcccggtga gcgctccacc 16800 cgcacctaca agcgcgtgta tgatgaggtg tacggcgacg aggacctgct tgagcaggcc 16860 aacgagcgcc tcggggagtt tgcctacgga aagcggcata aggacatgct ggcgttgccg 16920 ctggacgagg gcaacccaac acctagccta aagcccgtaa cactgcagca ggtgctgccc 16980 gcgcttgcac cgtccgaaga aaagcgcggc ctaaagcgcg agtctggtga cttggcaccc 17040 accgtgcagc tgatggtacc caagcgccag cgactggaag atgtcttgga aaaaatgacc 17100 gtggaacctg ggctggagcc cgaggtccgc gtgcggccaa tcaagcaggt ggcgccggga 17160 ctgggcgtgc agaccgtgga cgttcagata cccactacca gtagcaccag tattgccacc 17220 gccacagagg gcatggagac acaaacgtcc ccggttgcct cagcggtggc ggatgccgcg 17280 gtgcaggcgg tcgctgcggc cgcgtccaag acctctacgg aggtgcaaac ggacccgtgg 17340 atgtttcgcg tttcagcccc ccggcgcccg cgcggttcga ggaagtacgg cgccgccagc 17400 gcgctactgc ccgaatatgc cctacatcct tccattgcgc ctacccccgg ctatcgtggc 17460 tacacctacc gccccagaag acgagcaact acccgacgcc gaaccaccac tggaacccgc 17520 cgccgccgtc gccgtcgcca gcccgtgctg gccccgattt ccgtgcgcag ggtggctcgc 17580 gaaggaggca ggaccctggt gctgccaaca gcgcgctacc accccagcat cgtttaaaag 17640 ccggtctttg tggttcttgc agatatggcc ctcacctgcc gcctccgttt cccggtgccg 17700 ggattccgag gaagaatgca ccgtaggagg ggcatggccg gccacggcct gacgggcggc 17760 atgcgtcgtg cgcaccaccg gcggcggcgc gcgtcgcacc gtcgcatgcg cggcggtatc 17820 ctgcccctcc ttattccact gatcgccgcg gcgattggcg ccgtgcccgg aattgcatcc 17880 gtggccttgc aggcgcagag acactgatta aaaacaagtt gcatgtggaa aaatcaaaat 17940 aaaaagtctg gactctcacg ctcgcttggt cctgtaacta ttttgtagaa tggaagacat 18000 caactttgcg tctctggccc cgcgacacgg ctcgcgcccg ttcatgggaa actggcaaga 18060 tatcggcacc agcaatatga gcggtggcgc cttcagctgg ggctcgctgt ggagcggcat 18120 taaaaatttc ggttccaccg ttaagaacta tggcagcaag gcctggaaca gcagcacagg 18180 ccagatgctg agggataagt tgaaagagca aaatttccaa caaaaggtgg tagatggcct 18240 ggcctctggc attagcgggg tggtggacct ggccaaccag gcagtgcaaa ataagattaa 18300 cagtaagctt gatccccgcc ctcccgtaga ggagcctcca ccggccgtgg agacagtgtc 18360 tccagagggg cgtggcgaaa agcgtccgcg ccccgacagg gaagaaactc tggtgacgca 18420 aatagacgag cctccctcgt acgaggaggc actaaagcaa ggcctgccca ccacccgtcc 18480 catcgcgccc atggctaccg gagtgctggg ccagcacaca cccgtaacgc tggacctgcc 18540 tccccccgcc gacacccagc agaaacctgt gctgccaggc ccgaccgccg ttgttgtaac 18600 ccgtcctagc cgcgcgtccc tgcgccgcgc cgccagcggt ccgcgatcgt tgcggcccgt 18660 agccagtggc aactggcaaa gcacactgaa cagcatcgtg ggtctggggg tgcaatccct 18720 gaagcgccga cgatgcttct gaatagctaa cgtgtcgtat gtgtgtcatg tatgcgtcca 18780 tgtcgccgcc agaggagctg ctgagccgcc gcgcgcccgc tttccaagat ggctacccct 18840 tcgatgatgc cgcagtggtc ttacatgcac atctcgggcc aggacgcctc ggagtacctg 18900 agccccgggc tggtgcagtt tgcccgcgcc accgagacgt acttcagcct gaataacaag 18960 tttagaaacc ccacggtggc gcctacgcac gacgtgacca cagaccggtc ccagcgtttg 19020 acgctgcggt tcatccctgt ggaccgtgag gatactgcgt actcgtacaa ggcgcggttc 19080 accctagctg tgggtgataa ccgtgtgctg gacatggctt ccacgtactt tgacatccgc 19140 ggcgtgctgg acaggggccc tacttttaag ccctactctg gcactgccta caacgccctg 19200 gctcccaagg gtgccccaaa tccttgcgaa tgggatgaag ctgctactgc tcttgaaata 19260 aacctagaag aagaggacga tgacaacgaa gacgaagtag acgagcaagc tgagcagcaa 19320 aaaactcacg tatttgggca ggcgccttat tctggtataa atattacaaa ggagggtatt 19380 caaataggtg tcgaaggtca aacacctaaa tatgccgata aaacatttca acctgaacct 19440 caaataggag aatctcagtg gtacgaaact gaaattaatc atgcagctgg gagagtcctt 19500 aaaaagacta ccccaatgaa accatgttac ggttcatatg caaaacccac aaatgaaaat 19560 ggagggcaag gcattcttgt aaagcaacaa aatggaaagc tagaaagtca agtggaaatg 19620 caatttttct caactactga ggcgaccgca ggcaatggtg ataacttgac tcctaaagtg 19680 gtattgtaca gtgaagatgt agatatagaa accccagaca ctcatatttc ttacatgccc 19740 actattaagg aaggtaactc acgagaacta atgggccaac aatctatgcc caacaggcct 19800 aattacattg cttttaggga caattttatt ggtctaatgt attacaacag cacgggtaat 19860 atgggtgttc tggcgggcca agcatcgcag ttgaatgctg ttgtagattt gcaagacaga 19920 aacacagagc tttcatacca gcttttgctt gattccattg gtgatagaac caggtacttt 19980 tctatgtgga atcaggctgt tgacagctat gatccagatg ttagaattat tgaaaatcat 20040 ggaactgaag atgaacttcc aaattactgc tttccactgg gaggtgtgat taatacagag 20100 actcttacca aggtaaaacc taaaacaggt caggaaaatg gatgggaaaa agatgctaca 20160 gaattttcag ataaaaatga aataagagtt ggaaataatt ttgccatgga aatcaatcta 20220 aatgccaacc tgtggagaaa tttcctgtac tccaacatag cgctgtattt gcccgacaag 20280 ctaaagtaca gtccttccaa cgtaaaaatt tctgataacc caaacaccta cgactacatg 20340 aacaagcgag tggtggctcc cgggttagtg gactgctaca ttaaccttgg agcacgctgg 20400 tcccttgact atatggacaa cgtcaaccca tttaaccacc accgcaatgc tggcctgcgc 20460 taccgctcaa tgttgctggg caatggtcgc tatgtgccct tccacatcca ggtgcctcag 20520 aagttctttg ccattaaaaa cctccttctc ctgccgggct catacaccta cgagtggaac 20580 ttcaggaagg atgttaacat ggttctgcag agctccctag gaaatgacct aagggttgac 20640 ggagccagca ttaagtttga tagcatttgc ctttacgcca ccttcttccc catggcccac 20700 aacaccgcct ccacgcttga ggccatgctt agaaacgaca ccaacgacca gtcctttaac 20760 gactatctct ccgccgccaa catgctctac cctatacccg ccaacgctac caacgtgccc 20820 atatccatcc cctcccgcaa ctgggcggct ttccgcggct gggccttcac gcgccttaag 20880 actaaggaaa ccccatcact gggctcgggc tacgaccctt attacaccta ctctggctct 20940 ataccctacc tagatggaac cttttacctc aaccacacct ttaagaaggt ggccattacc 21000 tttgactctt ctgtcagctg gcctggcaat gaccgcctgc ttacccccaa cgagtttgaa 21060 attaagcgct cagttgacgg ggagggttac aacgttgccc agtgtaacat gaccaaagac 21120 tggttcctgg tacaaatgct agctaactac aacattggct accagggctt ctatatccca 21180 gagagctaca aggaccgcat gtactccttc tttagaaact tccagcccat gagccgtcag 21240 gtggtggatg atactaaata caaggactac caacaggtgg gcatcctaca ccaacacaac 21300 aactctggat ttgttggcta ccttgccccc accatgcgcg aaggacaggc ctaccctgct 21360 aacttcccct atccgcttat aggcaagacc gcagttgaca gcattaccca gaaaaagttt 21420 ctttgcgatc gcaccctttg gcgcatccca ttctccagta actttatgtc catgggcgca 21480 ctcacagacc tgggccaaaa ccttctctac gccaactccg cccacgcgct agacatgact 21540 tttgaggtgg atcccatgga cgagcccacc cttctttatg ttttgtttga agtctttgac 21600 gtggtccgtg tgcaccggcc gcaccgcggc gtcatcgaaa ccgtgtacct gcgcacgccc 21660 ttctcggccg gcaacgccac aacataaaga agcaagcaac atcaacaaca gctgccgcca 21720 tgggctccag tgagcaggaa ctgaaagcca ttgtcaaaga tcttggttgt gggccatatt 21780 ttttgggcac ctatgacaag cgctttccag gctttgtttc tccacacaag ctcgcctgcg 21840 ccatagtcaa tacggccggt cgcgagactg ggggcgtaca ctggatggcc tttgcctgga 21900 acccgcactc aaaaacatgc tacctctttg agccctttgg cttttctgac cagcgactca 21960 agcaggttta ccagtttgag tacgagtcac tcctgcgccg tagcgccatt gcttcttccc 22020 ccgaccgctg tataacgctg gaaaagtcca cccaaagcgt acaggggccc aactcggccg 22080 cctgtggact attctgctgc atgtttctcc acgcctttgc caactggccc caaactccca 22140 tggatcacaa ccccaccatg aaccttatta ccggggtacc caactccatg ctcaacagtc 22200 cccaggtaca gcccaccctg cgtcgcaacc aggaacagct ctacagcttc ctggagcgcc 22260 actcgcccta cttccgcagc cacagtgcgc agattaggag cgccacttct ttttgtcact 22320 tgaaaaacat gtaaaaataa tgtactagag acactttcaa taaaggcaaa tgcttttatt 22380 tgtacactct cgggtgatta tttaccccca cccttgccgt ctgcgccgtt taaaaatcaa 22440 aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga tactggtgtt 22500 tagtgctcca cttaaactca ggcacaacca tccgcggcag ctcggtgaag ttttcactcc 22560 acaggctgcg caccatcacc aacgcgttta gcaggtcggg cgccgatatc ttgaagtcgc 22620 agttggggcc tccgccctgc gcgcgcgagt tgcgatacac agggttgcag cactggaaca 22680 ctatcagcgc cgggtggtgc acgctggcca gcacgctctt gtcggagatc agatccgcgt 22740 ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt tggtagctgc cttcccaaaa 22800 agggcgcgtg cccaggcttt gagttgcact cgcaccgtag tggcatcaaa aggtgaccgt 22860 gcccggtctg ggcgttagga tacagcgcct gcataaaagc cttgatctgc ttaaaagcca 22920 cctgagcctt tgcgccttca gagaagaaca tgccgcaaga cttgccggaa aactgattgg 22980 ccggacaggc cgcgtcgtgc acgcagcacc ttgcgtcggt gttggagatc tgcaccacat 23040 ttcggcccca ccggttcttc acgatcttgg ccttgctaga ctgctccttc agcgcgcgct 23100 gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc cttatttatc ataatgcttc 23160 cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg gtgcagccac aacgcgcagc 23220 ccgtgggctc gtgatgcttg taggtcacct ctgcaaacga ctgcaggtac gcctgcagga 23280 atcgccccat catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc aacccgcggt 23340 gctcctcgtt cagccaggtc ttgcatacgg ccgccagagc ttccacttgg tcaggcagta 23400 gtttgaagtt cgcctttaga tcgttatcca cgtggtactt gtccatcagc gcgcgcgcag 23460 cctccatgcc cttctcccac gcagacacga tcggcacact cagcgggttc atcaccgtaa 23520 tttcactttc cgcttcgctg ggctcttcct cttcctcttg cgtccgcata ccacgcgcca 23580 ctgggtcgtc ttcattcagc cgccgcactg tgcgcttacc tcctttgcca tgcttgatta 23640 gcaccggtgg gttgctgaaa cccaccattt gtagcgccac atcttctctt tcttcctcgc 23700 tgtccacgat tacctctggt gatggcgggc gctcgggctt gggagaaggg cgcttctttt 23760 tcttcttggg cgcaatggcc aaatccgccg ccgaggtcga tggccgcggg ctgggtgtgc 23820 gcggcaccag cgcgtcttgt gatgagtctt cctcgtcctc ggactcgata cgccgcctca 23880 tccgcttttt tgggggcgcc cggggaggcg gcggcgacgg ggacggggac gacacgtcct 23940 ccatggttgg gggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt tcgcgctgct 24000 cctcttcccg actggccatt tccttctcct ataggcagaa aaagatcatg gagtcagtcg 24060 agaagaagga cagcctaacc gccccctctg agttcgccac caccgcctcc accgatgccg 24120 ccaacgcgcc taccaccttc cccgtcgagg cacccccgct tgaggaggag gaagtgatta 24180 tcgagcagga cccaggtttt gtaagcgaag acgacgagga ccgctcagta ccaacagagg 24240 ataaaaagca agaccaggac aacgcagagg caaacgagga acaagtcggg cggggggacg 24300 aaaggcatgg cgactaccta gatgtgggag acgacgtgct gttgaagcat ctgcagcgcc 24360 agtgcgccat tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc gccatagcgg 24420 atgtcagcct tgcctacgaa cgccacctat tctcaccgcg cgtacccccc aaacgccaag 24480 aaaacggcac atgcgagccc aacccgcgcc tcaacttcta ccccgtattt gccgtgccag 24540 aggtgcttgc cacctatcac atctttttcc aaaactgcaa gataccccta tcctgccgtg 24600 ccaaccgcag ccgagcggac aagcagctgg ccttgcggca gggcgctgtc atacctgata 24660 tcgcctcgct caacgaagtg ccaaaaatct ttgagggtct tggacgcgac gagaagcgcg 24720 cggcaaacgc tctgcaacag gaaaacagcg aaaatgaaag tcactctgga gtgttggtgg 24780 aactcgaggg tgacaacgcg cgcctagccg tactaaaacg cagcatcgag gtcacccact 24840 ttgcctaccc ggcacttaac ctacccccca aggtcatgag cacagtcatg agtgagctga 24900 tcgtgcgccg tgcgcagccc ctggagaggg atgcaaattt gcaagaacaa acagaggagg 24960 gcctacccgc agttggcgac gagcagctag cgcgctggct tcaaacgcgc gagcctgccg 25020 acttggagga gcgacgcaaa ctaatgatgg ccgcagtgct cgttaccgtg gagcttgagt 25080 gcatgcagcg gttctttgct gacccggaga tgcagcgcaa gctagaggaa acattgcact 25140 acacctttcg acagggctac gtacgccagg cctgcaagat ctccaacgtg gagctctgca 25200 acctggtctc ctaccttgga attttgcacg aaaaccgcct tgggcaaaac gtgcttcatt 25260 ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac ttatttctat 25320 gctacacctg gcagacggcc atgggcgttt ggcagcagtg cttggaggag tgcaacctca 25380 aggagctgca gaaactgcta aagcaaaact tgaaggacct atggacggcc ttcaacgagc 25440 gctccgtggc cgcgcacctg gcggacatca ttttccccga acgcctgctt aaaaccctgc 25500 aacagggtct gccagacttc accagtcaaa gcatgttgca gaactttagg aactttatcc 25560 tagagcgctc aggaatcttg cccgccacct gctgtgcact tcctagcgac tttgtgccca 25620 ttaagtaccg cgaatgccct ccgccgcttt ggggccactg ctaccttctg cagctagcca 25680 actaccttgc ctaccactct gacataatgg aagacgtgag cggtgacggt ctactggagt 25740 gtcactgtcg ctgcaaccta tgcaccccgc accgctccct ggtttgcaat tcgcagctgc 25800 ttaacgaaag tcaaattatc ggtacctttg agctgcaggg tccctcgcct gacgaaaagt 25860 ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac gtcggcttac cttcgcaaat 25920 ttgtacctga ggactaccac gcccacgaga ttaggttcta cgaagaccaa tcccgcccgc 25980 caaatgcgga gcttaccgcc tgcgtcatta cccagggcca cattcttggc caattgcaag 26040 ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg acggggggtt tacttggacc 26100 cccagtccgg cgaggagctc aacccaatcc ccccgccgcc gcagccctat cagcagcagc 26160 cgcgggccct tgcttcccag gatggcaccc aaaaagaagc tgcagctgcc gccgccaccc 26220 acggacgagg aggaatactg ggacagtcag gcagaggagg ttttggacga ggaggaggag 26280 gacatgatgg aagactggga gagcctagac gaggaagctt ccgaggtcga agaggtgtca 26340 gacgaaacac cgtcaccctc ggtcgcattc ccctcgccgg cgccccagaa atcggcaacc 26400 ggttccagca tggctacaac ctccgctcct caggcgccgc cggcactgcc cgttcgccga 26460 cccaaccgta gatgggacac cactggaacc agggccggta agtccaagca gccgccgccg 26520 ttagcccaag agcaacaaca gcgccaaggc taccgctcat ggcgcgggca caagaacgcc 26580 atagttgctt gcttgcaaga ctgtgggggc aacatctcct tcgcccgccg ctttcttctc 26640 taccatcacg gcgtggcctt cccccgtaac atcctgcatt actaccgtca tctctacagc 26700 ccatactgca ccggcggcag cggcagcggc agcaacagca gcggccacac agaagcaaag 26760 gcgaccggat agcaagactc tgacaaagcc caagaaatcc acagcggcgg cagcagcagg 26820 aggaggagcg ctgcgtctgg cgcccaacga acccgtatcg acccgcgagc ttagaaacag 26880 gatttttccc actctgtatg ctatatttca acagagcagg ggccaagaac aagagctgaa 26940 aataaaaaac aggtctctgc gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga 27000 tcagcttcgg cgcacgctgg aagacgcgga ggctctcttc agtaaatact gcgcgctgac 27060 tcttaaggac tagtttcgcg ccctttctca aatttaagcg cgaaaactac gtcatctcca 27120 gcggccacac ccggcgccag cacctgtcgt cagcgccatt tatgagcaag gaaattccca 27180 cgccctacat gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact 27240 actcaacccg aataaactac atgagcgcgg gaccccacat gatatcccgg gtcaacggaa 27300 tacgcgccca ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta 27360 ataaccttaa tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca 27420 ccactgtggt acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc 27480 agcttgcggg cggctttcgt cacagggtgc ggtcgcccgg gcagggtata actcacctga 27540 caatcagagg gcgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc 27600 gtccggacgg gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg 27660 caatcctaac tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactctgc 27720 aatttattga ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc 27780 actatccgga tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg 27840 actgaatgtt aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc 27900 gccacaagtg ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc 27960 atatcgaggg cccggcgcac ggcgtccggc ttaccgccca gggagagctt gcccgtagcc 28020 tgattcggga gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc 28080 tcactgtgat ttgcaactgt cctaaccctg gattacatca agatctttgt tgccatctct 28140 gtgctgagta taataaatac agaaattaaa atatactggg gctcctatcg ccatcctgta 28200 aacgccaccg tcttcacccg cccaagcaaa ccaaggcgaa ccttacctgg tacttttaac 28260 atctctccct ctgtgattta caacagtttc aacccagacg gagtgagtct acgagagaac 28320 ctctccgagc tcagctactc catcagaaaa aacaccaccc tccttacctg ccgggaacgt 28380 acgagtgcgt caccggccgc tgcaccacac ctaccgcctg accgtaaacc agactttttc 28440 cggacagacc tcaataactc tgtttaccag aacaggaggt gagcttagaa aacccttagg 28500 gtattaggcc aaaggcgcag ctactgtggg gtttatgaac aattcaagca actctacggg 28560 ctattctaat tcaggtttct ctagaatcgg ggttggggtt attctctgtc ttgtgattct 28620 ctttattctt atactaacgc ttctctgcct aaggctcgcc gcctgctgtg tgcacatttg 28680 catttattgt cagcttttta aacgctgggg tcgccaccca agatgattag gtacataatc 28740 ctaggtttac tcacccttgc gtcagcccac ggtaccaccc aaaaggtgga ttttaaggag 28800 ccagcctgta atgttacatt cgcagctgaa gctaatgagt gcaccactct tataaaatgc 28860 accacagaac atgaaaagct gcttattcgc cacaaaaaca aaattggcaa gtatgctgtt 28920 tatgctattt ggcagccagg tgacactaca gagtataatg ttacagtttt ccagggtaaa 28980 agtcataaaa cttttatgta tacttttcca ttttatgaaa tgtgcgacat taccatgtac 29040 atgagcaaac agtataagtt gtggccccca caaaattgtg tggaaaacac tggcactttc 29100 tgctgcactg ctatgctaat tacagtgctc gctttggtct gtaccctact ctatattaaa 29160 tacaaaagca gacgcagctt tattgaggaa aagaaaatgc cttaatttac taagttacaa 29220 agctaatgtc accactaact gctttactcg ctgcttgcaa aacaaattca aaaagttagc 29280 attataatta gaataggatt taaacccccc ggtcatttcc tgctcaatac cattcccctg 29340 aacaattgac tctatgtggg atatgctcca gcgctacaac cttgaagtca ggcttcctgg 29400 atgtcagcat ctgactttgg ccagcacctg tcccgcggat ttgttccagt ccaactacag 29460 cgacccaccc taacagagat gaccaacaca accaacgcgg ccgccgctac cggacttaca 29520 tctaccacaa atacacccca agtttctgcc tttgtcaata actgggataa cttgggcatg 29580 tggtggttct ccatagcgct tatgtttgta tgccttatta ttatgtggct catctgctgc 29640 ctaaagcgca aacgcgcccg accacccatc tatagtccca tcattgtgct acacccaaac 29700 aatgatggaa tccatagatt ggacggactg aaacacatgt tcttttctct tacagtatga 29760 ttaaatgaga catggccgtt cagctggtgg aaagtggcgg gggttctgtt caggcgggcg 29820 ggtctctgag gcttacttgc gccgcgagtg gtagaaccag tcggagctac ggaatggggt 29880 ggtttaggca agctcccggg aaagaacgcg aatttgtgag cggcattagc tggcggggcg 29940 attccactgg gtacgcagac tctgtaaagg gaaggtttac catcagccgc gataacgcaa 30000 agaacaccgt tgatctgcag atgaatagct tgagaccgga ggacaccgcc atctactact 30060 gtgcagctgc cgccggaagc acatggtatg ggactctgta tgaatacgac tactggggcc 30120 agggtacaca agttaccgta agcagcggct ctgggtccgg ctcgaccgga gtgcaggtgg 30180 aaaccatctc cccaggagac gggcgcacct tccccaagcg cggccagacc tgcgtggtgc 30240 actacaccgg gatgcttgaa gatggaaaga aatttgattc ctcccgggac agaaacaagc 30300 cctttaagtt tatgctaggc aagcaggagg tgatccgagg ctgggaagaa ggggttgccc 30360 agatgagtgt gggtcagaga gccaaactga ctatatctcc agattatgcc tatggtgcca 30420 ctgggcaccc aggcatcatc ccaccacatg ccactctcgt cttcgatgtg gagcttctaa 30480 aactgtaata aaaaaaaata ataaagcatc acttacttaa aatcagttag caaatttctg 30540 tccagtttat tcagcagcac ctccttgccc tcctcccagc tctggtattg cagcttcctc 30600 ctggctgcaa actttctcca caatctaaat ggaatgtcag tttcctcctg ttcctgtcca 30660 tccgcaccca ctatcttcat gttgttgcag atgaagcgcg caagaccgtc tgaagatacc 30720 ttcaaccccg tgtatccata tgacacggaa accggtcctc caactgtgcc ttttcttact 30780 cctccctttg tatcccccaa tgggtttcaa gagagtcccc ctggggtact ctctttgcgc 30840 ctatccgaac ctctagttac ctccaatggc atgcttgcgc tcaaaatggg caacggcctc 30900 tctctggacg aggccggcaa ccttacctcc caaaatgtaa ccactgtgag cccacctctc 30960 aaaaaaacca agtcaaacat aaacctggaa atatctgcac ccctcacagt tacctcagaa 31020 gccctaactg tggctgccgc cgcacctcta atggtcgcgg gcaacacact caccatgcaa 31080 tcacaggccc cgctaaccgt gcacgactcc aaacttagca ttgccaccca aggacccctc 31140 acagtgtcag aaggaaagct agccctgcaa acatcaggcc ccctcaccac caccgatagc 31200 agtaccctta ctatcactgc ctcaccccct ctaactactg ccactggtag cttgggcatt 31260 gacttgaaag agcccattta tacacaaaat ggaaaactag gactaaagta cggggctcct 31320 ttgcatgtaa cagacgacct aaacactttg accgtagcaa ctggtccagg tgtgactatt 31380 aataatactt ccttgcaaac taaagttact ggagccttgg gttttgattc acaaggcaat 31440 atgcaactta atgtagcagg aggactaagg attgattctc aaaacagacg ccttatactt 31500 gatgttagtt atccgtttga tgctcaaaac caactaaatc taagactagg acagggccct 31560 ctttttataa actcagccca caacttggat attaactaca acaaaggcct ttacttgttt 31620 acagcttcaa acaattccaa aaagcttgag gttaacctaa gcactgccaa ggggttgatg 31680 tttgacgcta cagccatagc cattaatgca ggagatgggc ttgaatttgg ttcacctaat 31740 gcaccaaaca caaatcccct caaaacaaaa attggccatg gcctagaatt tgattcaaac 31800 aaggctatgg ttcctaaact aggaactggc cttagttttg acagcacagg tgccattaca 31860 gtaggaaaca aaaataatga taagctaact ttgtggacca caccagctcc atctcctaac 31920 tgtagactaa atgcagagaa agatgctaaa ctcactttgg tcttaacaaa atgtggcagt 31980 caaatacttg ctacagtttc agttttggct gttaaaggca gtttggctcc aatatctgga 32040 acagttcaaa gtgctcatct tattataaga tttgacgaaa atggagtgct actaaacaat 32100 tccttcctgg acccagaata ttggaacttt agaaatggag atcttactga aggcacagcc 32160 tatacaaacg ctgttggatt tatgcctaac ctatcagctt atccaaaatc tcacggtaaa 32220 actgccaaaa gtaacattgt cagtcaagtt tacttaaacg gagacaaaac taaacctgta 32280 acactaacca ttacactaaa cggtacacag gaaacaggag acacaactga gatgtggcat 32340 gaaggcctag aagaggcctc tcgcttgtac tttggggaga ggaacgtcaa aggcatgttt 32400 gaggtgctgg agcccctgca tgctatgatg gaacgcggtc cccagaccct gaaggaaacg 32460 tcctttaatc aggcatatgg tcgagattta atggaggcac aagaatggtg ccgaaagtac 32520 atgaaatcag ggaacgtcaa ggacctcctc caagcctggg acctctacta tcacgtgttc 32580 agacgaatct caaagcagcc aagtgcatac tctatgtcat tttcatggga ctggtctggc 32640 cacaactaca ttaatgaaat atttgccaca tcctcttaca ctttttcata cattgcccaa 32700 gaataaagaa tcgtttgtgt tatgtttcaa cgtgtttatt tttcaattgc agaaaatttc 32760 aagtcatttt tcattcagta gtatagcccc accaccacat agcttataca gatcaccgta 32820 ccttaatcaa acctacatgg gggtagagtc ataatcgtgc atcaggatag ggcggtggtg 32880 ctgcagcagc gcgcgaataa actgctgccg ccgccgctcc gtcctgcagg aatacaacat 32940 ggcagtggtc tcctcagcga tgattcgcac cgcccgcagc ataaggcgcc ttgtcctccg 33000 ggcacagcag cgcaccctga tctcacttaa atcagcacag taactgcagc acagcaccac 33060 aatattgttc aaaatcccac agtgcaaggc gctgtatcca aagctcatgg cggggaccac 33120 agaacccacg tggccatcat accacaagcg caggtagatt aagtggcgac ccctcataaa 33180 cacgctggac ataaacatta cctcttttgg catgttgtaa ttcaccacct cccggtacca 33240 tataaacctc tgattaaaca tggcgccatc caccaccatc ctaaaccagc tggccaaaac 33300 ctgcccgccg gctatacact gcagggaacc gggactggaa caatgacagt ggagagccca 33360 ggactcgtaa ccatggatca tcatgctcgt catgatatca atgttggcac aacacaggca 33420 cacgtgcata cacttcctca ggattacaag ctcctcccgc gttagaacca tatcccaggg 33480 aacaacccat tcctgaatca gcgtaaatcc cacactgcag ggaagacctc gcacgtaact 33540 cacgttgtgc attgtcaaag tgttacattc gggcagcagc ggatgatcct ccagtatggt 33600 agcgcgggtt tctgtctcaa aaggaggtag acgatcccta ctgtacggag tgcgccgaga 33660 caaccgagat cgtgttggtc gtagtgtcat gccaaatgga acgccggacg tagtcatatt 33720 tcctgaagca aaaccaggtg cgggcgtgac aaacagatct gcgtctccgg tctcgccgct 33780 tagatcgctc tgtgtagtag ttgtagtata tccactctct caaagcatcc aggcgccccc 33840 tggcttcggg ttctatgtaa actccttcat gcgccgctgc cctgataaca tccaccaccg 33900 cagaataagc cacacccagc caacctacac attcgttctg cgagtcacac acgggaggag 33960 cgggaagagc tggaagaacc atgttttttt ttttattcca aaagattatc caaaacctca 34020 aaatgaagat ctattaagtg aacgcgctcc cctccggtgg cgtggtcaaa ctctacagcc 34080 aaagaacaga taatggcatt tgtaagatgt tgcacaatgg cttccaaaag gcaaacggcc 34140 ctcacgtcca agtggacgta aaggctaaac ccttcagggt gaatctcctc tataaacatt 34200 ccagcacctt caaccatgcc caaataattc tcatctcgcc accttctcaa tatatctcta 34260 agcaaatccc gaatattaag tccggccatt gtaaaaatct gctccagagc gccctccacc 34320 ttcagcctca agcagcgaat catgattgca aaaattcagg ttcctcacag acctgtataa 34380 gattcaaaag cggaacatta acaaaaatac cgcgatcccg taggtccctt cgcagggcca 34440 gctgaacata atcgtgcagg tctgcacgga ccagcgcggc cacttccccg ccaggaacca 34500 tgacaaaaga acccacactg attatgacac gcatactcgg agctatgcta accagcgtag 34560 ccccgatgta agcttgttgc atgggcggcg atataaaatg caaggtgctg ctcaaaaaat 34620 caggcaaagc ctcgcgcaaa aaagaaagca catcgtagtc atgctcatgc agataaaggc 34680 aggtaagctc cggaaccacc acagaaaaag acaccatttt tctctcaaac atgtctgcgg 34740 gtttctgcat aaacacaaaa taaaataaca aaaaaacatt taaacattag aagcctgtct 34800 tacaacagga aaaacaaccc ttataagcat aagacggact acggccatgc cggcgtgacc 34860 gtaaaaaaac tggtcaccgt gattaaaaag caccaccgac agctcctcgg tcatgtccgg 34920 agtcataatg taagactcgg taaacacatc aggttgattc acatcggtca gtgctaaaaa 34980 gcgaccgaaa tagcccgggg gaatacatac ccgcaggcgt agagacaaca ttacagcccc 35040 cataggaggt ataacaaaat taataggaga gaaaaacaca taaacacctg aaaaaccctc 35100 ctgcctaggc aaaatagcac cctcccgctc cagaacaaca tacagcgctt ccacagcggc 35160 agccataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac 35220 acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc gagtatatat 35280 aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg 35340 aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg tcacttccgt 35400 tttcccacgt tacgtcactt cccattttaa gaaaactaca attcccaaca catacaagtt 35460 actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac 35520 tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat tgatgatg 35578 <210> 26 <211> 35578 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO313) <400> 26 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagca taagtgtctt gctgtcttta 4080 tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct 4140 gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag 4200 cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta 4260 gatgatccag tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa 4320 gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg 4380 gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc 4440 agccatatcc ctccggggat tcatgttgtg cagaaccacc agcacagtgt atccggtgca 4500 cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt 4560 gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc 4620 ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc 4680 gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcggta taatggttcc 4740 atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga 4800 tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg taggggagat 4860 cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta 4920 aatcacacct attaccgggt gcaactggta gttaagagag ctgcagctgc cgtcatccct 4980 gagcaggggg gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc 5040 cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa 5100 cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg 5160 gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc 5220 gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc 5280 atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc 5340 gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc 5400 tgccggtctt cgccctgcgc gtcggccagg tagcatttga ccatggtgtc atagtccagc 5460 ccctccgcgg cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg 5520 cagtgcagac ttttgagggc gtagagcttg ggcgcgagaa ataccgattc cggggagtag 5580 gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc 5640 cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt 5700 tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac 5760 ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac 5820 tctgagacaa aggctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg 5880 tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg 5940 gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg 6000 gggctataaa agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg 6060 agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga 6120 ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg 6180 agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca 6240 aacgacccgt agagggcgtt ggacagcaac ttggcgatgg agcgcagggt ttggtttttg 6300 tcgcgatcgg cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac 6360 cgccattcgg gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg 6420 ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc 6480 cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg 6540 tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct 6600 atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg 6660 tatgggttga gtgggggacc ccatggcatg gggtgggtga gcgcggaggc gtacatgccg 6720 caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt 6780 ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg 6840 ggaccgaggt tgctacgggc gggctgctct gctcggaaga ctatctgcct gaagatggca 6900 tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct 6960 accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg 7020 acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt 7080 cccttttttt tccacagctc gcggttgagg acaaactctt cgcggtcttt ccagtactct 7140 tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg 7200 gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg 7260 agcgaggtgt gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg 7320 aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa 7380 cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata 7440 aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg 7500 gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag ttccaagaag 7560 cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg 7620 gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat 7680 gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg 7740 cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag 7800 cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg 7860 ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta 7920 taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg 7980 aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag 8040 tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag 8100 cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag 8160 agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct 8220 tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc 8280 gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga 8340 tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg 8400 tttacctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg 8460 ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg 8520 gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt 8580 gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg 8640 gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg 8700 cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg 8760 tgagcttgag cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct 8820 ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact 8880 gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt 8940 cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc 9000 ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga 9060 gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg 9120 tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt 9180 tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga 9240 aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg 9300 cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct 9360 cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac 9420 ggcggcgacg acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc 9480 gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc 9540 cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc 9600 taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt 9660 ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 9720 gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg 9780 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca 9840 ccatgtcctt gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt 9900 tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt 9960 cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg 10020 gccgtaggtg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa 10080 gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg 10140 tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag 10200 tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt 10260 acctgagacg cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt 10320 actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg 10380 ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg 10440 acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc 10500 agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg gtcaggcgcg 10560 cgcaatcgtt gacgctctag accgtgcaaa aggagagcct gtaagcgggc actcttccgt 10620 ggtctggtgg ataaattcgc aagggtatca tggcggacga ccggggttcg agccccgtat 10680 ccggccgtcc gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg 10740 tcagacaacg ggggagtgct ccttttggct tccttccagg cgcggcggct gctgcgctag 10800 cttttttggc cactggccgc gcgcagcgta agcggttagg ctggaaagcg aaagcattaa 10860 gtggctcgct ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg ggacccccgg 10920 ttcgagtctc ggaccggccg gactgcggcg aacgggggtt tgcctccccg tcatgcaaga 10980 ccccgcttgc aaattcctcc ggaaacaggg acgagcccct tttttgcttt tcccagatgc 11040 atccggtgct gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc 11100 agacatgcag ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca tccgcggttg 11160 acgcggcagc agatggtgat tacgaacccc cgcggcgccg ggcccggcac tacctggact 11220 tggaggaggg cgagggcctg gcgcggctag gagcgccctc tcctgagcgg tacccaaggg 11280 tgcagctgaa gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc 11340 gcgagggaga ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc 11400 ggcatggcct gaatcgcgag cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa 11460 ccgggattag tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc gcatacgagc 11520 agacggtgaa ccaggagatt aactttcaaa aaagctttaa caaccacgtg cgtacgcttg 11580 tggcgcgcga ggaggtggct ataggactga tgcatctgtg ggactttgta agcgcgctgg 11640 agcaaaaccc aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg cagcacagca 11700 gggacaacga ggcattcagg gatgcgctgc taaacatagt agagcccgag ggccgctggc 11760 tgctcgattt gataaacatc ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg 11820 ctgacaaggt ggccgccatc aactattcca tgcttagcct gggcaagttt tacgcccgca 11880 agatatacca taccccttac gttcccatag acaaggaggt aaagatcgag gggttctaca 11940 tgcgcatggc gctgaaggtg cttaccttga gcgacgacct gggcgtttat cgcaacgagc 12000 gcatccacaa ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc 12060 acagcctgca aagggccctg gctggcacgg gcagcggcga tagagaggcc gagtcctact 12120 ttgacgcggg cgctgacctg cgctgggccc caagccgacg cgccctggag gcagctgggg 12180 ccggacctgg gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat 12240 atgacgagga cgatgagtac gagccagagg acggcgagta ctaagcggtg atgtttctga 12300 tcagatgatg caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc 12360 cggccttaac tccacggacg actggcgcca ggtcatggac cgcatcatgt cgctgactgc 12420 gcgcaatcct gacgcgttcc ggcagcagcc gcaggccaac cggctctccg caattctgga 12480 agcggtggtc ccggcgcgcg caaaccccac gcacgagaag gtgctggcga tcgtaaacgc 12540 gctggccgaa aacagggcca tccggcccga cgaggccggc ctggtctacg acgcgctgct 12600 tcagcgcgtg gctcgttaca acagcggcaa cgtgcagacc aacctggacc ggctggtggg 12660 ggatgtgcgc gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca acctgggctc 12720 catggttgca ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc ggggacagga 12780 ggactacacc aactttgtga gcgcactgcg gctaatggtg actgagacac cgcaaagtga 12840 ggtgtaccag tctgggccag actatttttt ccagaccagt agacaaggcc tgcagaccgt 12900 aaacctgagc caggctttca aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg 12960 cgaccgcgcg accgtgtcta gcttgctgac gcccaactcg cgcctgttgc tgctgctaat 13020 agcgcccttc acggacagtg gcagcgtgtc ccgggacaca tacctaggtc acttgctgac 13080 actgtaccgc gaggccatag gtcaggcgca tgtggacgag catactttcc aggagattac 13140 aagtgtcagc cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa ccctaaacta 13200 cctgctgacc aaccggcggc agaagatccc ctcgttgcac agtttaaaca gcgaggagga 13260 gcgcattttg cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg acggggtaac 13320 gcccagcgtg gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa 13380 ccggccgttt atcaaccgcc taatggacta cttgcatcgc gcggccgccg tgaaccccga 13440 gtatttcacc aatgccatct tgaacccgca ctggctaccg ccccctggtt tctacaccgg 13500 gggattcgag gtgcccgagg gtaacgatgg attcctctgg gacgacatag acgacagcgt 13560 gttttccccg caaccgcaga ccctgctaga gttgcaacag cgcgagcagg cagaggcggc 13620 gctgcgaaag gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc 13680 gcggtcagat gctagtagcc catttccaag cttgataggg tctcttacca gcactcgcac 13740 cacccgcccg cgcctgctgg gcgaggagga gtacctaaac aactcgctgc tgcagccgca 13800 gcgcgaaaaa aacctgcctc cggcatttcc caacaacggg atagagagcc tagtggacaa 13860 gatgagtaga tggaagacgt acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc 13920 cacccgtcgt caaaggcacg accgtcagcg gggtctggtg tgggaggacg atgactcggc 13980 agacgacagc agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc accttcgccc 14040 caggctgggg agaatgtttt aaaaaaaaaa aagcatgatg caaaataaaa aactcaccaa 14100 ggccatggca ccgagcgttg gttttcttgt attcccctta gtatgcggcg cgcggcgatg 14160 tatgaggaag gtcctcctcc ctcctacgag agtgtggtga gcgcggcgcc agtggcggcg 14220 gcgctgggtt ctcccttcga tgctcccctg gacccgccgt ttgtgcctcc gcggtacctg 14280 cggcctaccg gggggagaaa cagcatccgt tactctgagt tggcacccct attcgacacc 14340 acccgtgtgt acctggtgga caacaagtca acggatgtgg catccctgaa ctaccagaac 14400 gaccacagca actttctgac cacggtcatt caaaacaatg actacagccc gggggaggca 14460 agcacacaga ccatcaatct tgacgaccgg tcgcactggg gcggcgacct gaaaaccatc 14520 ctgcatacca acatgccaaa tgtgaacgag ttcatgttta ccaataagtt taaggcgcgg 14580 gtgatggtgt cgcgcttgcc tactaaggac aatcaggtgg agctgaaata cgagtgggtg 14640 gagttcacgc tgcccgaggg caactactcc gagaccatga ccatagacct tatgaacaac 14700 gcgatcgtgg agcactactt gaaagtgggc agacagaacg gggttctgga aagcgacatc 14760 ggggtaaagt ttgacacccg caacttcaga ctggggtttg accccgtcac tggtcttgtc 14820 atgcctgggg tatatacaaa cgaagccttc catccagaca tcattttgct gccaggatgc 14880 ggggtggact tcacccacag ccgcctgagc aacttgttgg gcatccgcaa gcggcaaccc 14940 ttccaggagg gctttaggat cacctacgat gatctggagg gtggtaacat tcccgcactg 15000 ttggatgtgg acgcctacca ggcgagcttg aaagatgaca ccgaacaggg cgggggtggc 15060 gcaggcggca gcaacagcag tggcagcggc gcggaagaga actccaacgc ggcagccgcg 15120 gcaatgcagc cggtggagga catgaacgat catgccattc gcggcgacac ctttgccaca 15180 cgggctgagg agaagcgcgc tgaggccgaa gcagcggccg aagctgccgc ccccgctgcg 15240 caacccgagg tcgagaagcc tcagaagaaa ccggtgatca aacccctgac agaggacagc 15300 aagaaacgca gttacaacct aataagcaat gacagcacct tcacccagta ccgcagctgg 15360 taccttgcat acaactacgg cgaccctcag accggaatcc gctcatggac cctgctttgc 15420 actcctgacg taacctgcgg ctcggagcag gtctactggt cgttgccaga catgatgcaa 15480 gaccccgtga ccttccgctc cacgcgccag atcagcaact ttccggtggt gggcgccgag 15540 ctgttgcccg tgcactccaa gagcttctac aacgaccagg ccgtctactc ccaactcatc 15600 cgccagttta cctctctgac ccacgtgttc aatcgctttc ccgagaacca gattttggcg 15660 cgcccgccag cccccaccat caccaccgtc agtgaaaacg ttcctgctct cacagatcac 15720 gggacgctac cgctgcgcaa cagcatcgga ggagtccagc gagtgaccat tactgacgcc 15780 agacgccgca cctgccccta cgtttacaag gccctgggca tagtctcgcc gcgcgtccta 15840 tcgagccgca ctttttgagc aagcatgtcc atccttatat cgcccagcaa taacacaggc 15900 tggggcctgc gcttcccaag caagatgttt ggcggggcca agaagcgctc cgaccaacac 15960 ccagtgcgcg tgcgcgggca ctaccgcgcg ccctggggcg cgcacaaacg cggccgcact 16020 gggcgcacca ccgtcgatga cgccatcgac gcggtggtgg aggaggcgcg caactacacg 16080 cccacgccgc caccagtgtc cacagtggac gcggccattc agaccgtggt gcgcggagcc 16140 cggcgctatg ctaaaatgaa gagacggcgg aggcgcgtag cacgtcgcca ccgccgccga 16200 cccggcactg ccgcccaacg cgcggcggcg gccctgctta accgcgcacg tcgcaccggc 16260 cgacgggcgg ccatgcgggc cgctcgaagg ctggccgcgg gtattgtcac tgtgcccccc 16320 aggtccaggc gacgagcggc cgccgcagca gccgcggcca ttagtgctat gactcagggt 16380 cgcaggggca acgtgtattg ggtgcgcgac tcggttagcg gcctgcgcgt gcccgtgcgc 16440 acccgccccc cgcgcaacta gattgcaaga aaaaactact tagactcgta ctgttgtatg 16500 tatccagcgg cggcggcgcg caacgaagct atgtccaagc gcaaaatcaa agaagagatg 16560 ctccaggtca tcgcgccgga gatctatggc cccccgaaga aggaagagca ggattacaag 16620 ccccgaaagc taaagcgggt caaaaagaaa aagaaagatg atgatgatga acttgacgac 16680 gaggtggaac tgctgcacgc taccgcgccc aggcgacggg tacagtggaa aggtcgacgc 16740 gtaaaacgtg ttttgcgacc cggcaccacc gtagtcttta cgcccggtga gcgctccacc 16800 cgcacctaca agcgcgtgta tgatgaggtg tacggcgacg aggacctgct tgagcaggcc 16860 aacgagcgcc tcggggagtt tgcctacgga aagcggcata aggacatgct ggcgttgccg 16920 ctggacgagg gcaacccaac acctagccta aagcccgtaa cactgcagca ggtgctgccc 16980 gcgcttgcac cgtccgaaga aaagcgcggc ctaaagcgcg agtctggtga cttggcaccc 17040 accgtgcagc tgatggtacc caagcgccag cgactggaag atgtcttgga aaaaatgacc 17100 gtggaacctg ggctggagcc cgaggtccgc gtgcggccaa tcaagcaggt ggcgccggga 17160 ctgggcgtgc agaccgtgga cgttcagata cccactacca gtagcaccag tattgccacc 17220 gccacagagg gcatggagac acaaacgtcc ccggttgcct cagcggtggc ggatgccgcg 17280 gtgcaggcgg tcgctgcggc cgcgtccaag acctctacgg aggtgcaaac ggacccgtgg 17340 atgtttcgcg tttcagcccc ccggcgcccg cgcggttcga ggaagtacgg cgccgccagc 17400 gcgctactgc ccgaatatgc cctacatcct tccattgcgc ctacccccgg ctatcgtggc 17460 tacacctacc gccccagaag acgagcaact acccgacgcc gaaccaccac tggaacccgc 17520 cgccgccgtc gccgtcgcca gcccgtgctg gccccgattt ccgtgcgcag ggtggctcgc 17580 gaaggaggca ggaccctggt gctgccaaca gcgcgctacc accccagcat cgtttaaaag 17640 ccggtctttg tggttcttgc agatatggcc ctcacctgcc gcctccgttt cccggtgccg 17700 ggattccgag gaagaatgca ccgtaggagg ggcatggccg gccacggcct gacgggcggc 17760 atgcgtcgtg cgcaccaccg gcggcggcgc gcgtcgcacc gtcgcatgcg cggcggtatc 17820 ctgcccctcc ttattccact gatcgccgcg gcgattggcg ccgtgcccgg aattgcatcc 17880 gtggccttgc aggcgcagag acactgatta aaaacaagtt gcatgtggaa aaatcaaaat 17940 aaaaagtctg gactctcacg ctcgcttggt cctgtaacta ttttgtagaa tggaagacat 18000 caactttgcg tctctggccc cgcgacacgg ctcgcgcccg ttcatgggaa actggcaaga 18060 tatcggcacc agcaatatga gcggtggcgc cttcagctgg ggctcgctgt ggagcggcat 18120 taaaaatttc ggttccaccg ttaagaacta tggcagcaag gcctggaaca gcagcacagg 18180 ccagatgctg agggataagt tgaaagagca aaatttccaa caaaaggtgg tagatggcct 18240 ggcctctggc attagcgggg tggtggacct ggccaaccag gcagtgcaaa ataagattaa 18300 cagtaagctt gatccccgcc ctcccgtaga ggagcctcca ccggccgtgg agacagtgtc 18360 tccagagggg cgtggcgaaa agcgtccgcg ccccgacagg gaagaaactc tggtgacgca 18420 aatagacgag cctccctcgt acgaggaggc actaaagcaa ggcctgccca ccacccgtcc 18480 catcgcgccc atggctaccg gagtgctggg ccagcacaca cccgtaacgc tggacctgcc 18540 tccccccgcc gacacccagc agaaacctgt gctgccaggc ccgaccgccg ttgttgtaac 18600 ccgtcctagc cgcgcgtccc tgcgccgcgc cgccagcggt ccgcgatcgt tgcggcccgt 18660 agccagtggc aactggcaaa gcacactgaa cagcatcgtg ggtctggggg tgcaatccct 18720 gaagcgccga cgatgcttct gaatagctaa cgtgtcgtat gtgtgtcatg tatgcgtcca 18780 tgtcgccgcc agaggagctg ctgagccgcc gcgcgcccgc tttccaagat ggctacccct 18840 tcgatgatgc cgcagtggtc ttacatgcac atctcgggcc aggacgcctc ggagtacctg 18900 agccccgggc tggtgcagtt tgcccgcgcc accgagacgt acttcagcct gaataacaag 18960 tttagaaacc ccacggtggc gcctacgcac gacgtgacca cagaccggtc ccagcgtttg 19020 acgctgcggt tcatccctgt ggaccgtgag gatactgcgt actcgtacaa ggcgcggttc 19080 accctagctg tgggtgataa ccgtgtgctg gacatggctt ccacgtactt tgacatccgc 19140 ggcgtgctgg acaggggccc tacttttaag ccctactctg gcactgccta caacgccctg 19200 gctcccaagg gtgccccaaa tccttgcgaa tgggatgaag ctgctactgc tcttgaaata 19260 aacctagaag aagaggacga tgacaacgaa gacgaagtag acgagcaagc tgagcagcaa 19320 aaaactcacg tatttgggca ggcgccttat tctggtataa atattacaaa ggagggtatt 19380 caaataggtg tcgaaggtca aacacctaaa tatgccgata aaacatttca acctgaacct 19440 caaataggag aatctcagtg gtacgaaact gaaattaatc atgcagctgg gagagtcctt 19500 aaaaagacta ccccaatgaa accatgttac ggttcatatg caaaacccac aaatgaaaat 19560 ggagggcaag gcattcttgt aaagcaacaa aatggaaagc tagaaagtca agtggaaatg 19620 caatttttct caactactga ggcgaccgca ggcaatggtg ataacttgac tcctaaagtg 19680 gtattgtaca gtgaagatgt agatatagaa accccagaca ctcatatttc ttacatgccc 19740 actattaagg aaggtaactc acgagaacta atgggccaac aatctatgcc caacaggcct 19800 aattacattg cttttaggga caattttatt ggtctaatgt attacaacag cacgggtaat 19860 atgggtgttc tggcgggcca agcatcgcag ttgaatgctg ttgtagattt gcaagacaga 19920 aacacagagc tttcatacca gcttttgctt gattccattg gtgatagaac caggtacttt 19980 tctatgtgga atcaggctgt tgacagctat gatccagatg ttagaattat tgaaaatcat 20040 ggaactgaag atgaacttcc aaattactgc tttccactgg gaggtgtgat taatacagag 20100 actcttacca aggtaaaacc taaaacaggt caggaaaatg gatgggaaaa agatgctaca 20160 gaattttcag ataaaaatga aataagagtt ggaaataatt ttgccatgga aatcaatcta 20220 aatgccaacc tgtggagaaa tttcctgtac tccaacatag cgctgtattt gcccgacaag 20280 ctaaagtaca gtccttccaa cgtaaaaatt tctgataacc caaacaccta cgactacatg 20340 aacaagcgag tggtggctcc cgggttagtg gactgctaca ttaaccttgg agcacgctgg 20400 tcccttgact atatggacaa cgtcaaccca tttaaccacc accgcaatgc tggcctgcgc 20460 taccgctcaa tgttgctggg caatggtcgc tatgtgccct tccacatcca ggtgcctcag 20520 aagttctttg ccattaaaaa cctccttctc ctgccgggct catacaccta cgagtggaac 20580 ttcaggaagg atgttaacat ggttctgcag agctccctag gaaatgacct aagggttgac 20640 ggagccagca ttaagtttga tagcatttgc ctttacgcca ccttcttccc catggcccac 20700 aacaccgcct ccacgcttga ggccatgctt agaaacgaca ccaacgacca gtcctttaac 20760 gactatctct ccgccgccaa catgctctac cctatacccg ccaacgctac caacgtgccc 20820 atatccatcc cctcccgcaa ctgggcggct ttccgcggct gggccttcac gcgccttaag 20880 actaaggaaa ccccatcact gggctcgggc tacgaccctt attacaccta ctctggctct 20940 ataccctacc tagatggaac cttttacctc aaccacacct ttaagaaggt ggccattacc 21000 tttgactctt ctgtcagctg gcctggcaat gaccgcctgc ttacccccaa cgagtttgaa 21060 attaagcgct cagttgacgg ggagggttac aacgttgccc agtgtaacat gaccaaagac 21120 tggttcctgg tacaaatgct agctaactac aacattggct accagggctt ctatatccca 21180 gagagctaca aggaccgcat gtactccttc tttagaaact tccagcccat gagccgtcag 21240 gtggtggatg atactaaata caaggactac caacaggtgg gcatcctaca ccaacacaac 21300 aactctggat ttgttggcta ccttgccccc accatgcgcg aaggacaggc ctaccctgct 21360 aacttcccct atccgcttat aggcaagacc gcagttgaca gcattaccca gaaaaagttt 21420 ctttgcgatc gcaccctttg gcgcatccca ttctccagta actttatgtc catgggcgca 21480 ctcacagacc tgggccaaaa ccttctctac gccaactccg cccacgcgct agacatgact 21540 tttgaggtgg atcccatgga cgagcccacc cttctttatg ttttgtttga agtctttgac 21600 gtggtccgtg tgcaccggcc gcaccgcggc gtcatcgaaa ccgtgtacct gcgcacgccc 21660 ttctcggccg gcaacgccac aacataaaga agcaagcaac atcaacaaca gctgccgcca 21720 tgggctccag tgagcaggaa ctgaaagcca ttgtcaaaga tcttggttgt gggccatatt 21780 ttttgggcac ctatgacaag cgctttccag gctttgtttc tccacacaag ctcgcctgcg 21840 ccatagtcaa tacggccggt cgcgagactg ggggcgtaca ctggatggcc tttgcctgga 21900 acccgcactc aaaaacatgc tacctctttg agccctttgg cttttctgac cagcgactca 21960 agcaggttta ccagtttgag tacgagtcac tcctgcgccg tagcgccatt gcttcttccc 22020 ccgaccgctg tataacgctg gaaaagtcca cccaaagcgt acaggggccc aactcggccg 22080 cctgtggact attctgctgc atgtttctcc acgcctttgc caactggccc caaactccca 22140 tggatcacaa ccccaccatg aaccttatta ccggggtacc caactccatg ctcaacagtc 22200 cccaggtaca gcccaccctg cgtcgcaacc aggaacagct ctacagcttc ctggagcgcc 22260 actcgcccta cttccgcagc cacagtgcgc agattaggag cgccacttct ttttgtcact 22320 tgaaaaacat gtaaaaataa tgtactagag acactttcaa taaaggcaaa tgcttttatt 22380 tgtacactct cgggtgatta tttaccccca cccttgccgt ctgcgccgtt taaaaatcaa 22440 aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga tactggtgtt 22500 tagtgctcca cttaaactca ggcacaacca tccgcggcag ctcggtgaag ttttcactcc 22560 acaggctgcg caccatcacc aacgcgttta gcaggtcggg cgccgatatc ttgaagtcgc 22620 agttggggcc tccgccctgc gcgcgcgagt tgcgatacac agggttgcag cactggaaca 22680 ctatcagcgc cgggtggtgc acgctggcca gcacgctctt gtcggagatc agatccgcgt 22740 ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt tggtagctgc cttcccaaaa 22800 agggcgcgtg cccaggcttt gagttgcact cgcaccgtag tggcatcaaa aggtgaccgt 22860 gcccggtctg ggcgttagga tacagcgcct gcataaaagc cttgatctgc ttaaaagcca 22920 cctgagcctt tgcgccttca gagaagaaca tgccgcaaga cttgccggaa aactgattgg 22980 ccggacaggc cgcgtcgtgc acgcagcacc ttgcgtcggt gttggagatc tgcaccacat 23040 ttcggcccca ccggttcttc acgatcttgg ccttgctaga ctgctccttc agcgcgcgct 23100 gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc cttatttatc ataatgcttc 23160 cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg gtgcagccac aacgcgcagc 23220 ccgtgggctc gtgatgcttg taggtcacct ctgcaaacga ctgcaggtac gcctgcagga 23280 atcgccccat catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc aacccgcggt 23340 gctcctcgtt cagccaggtc ttgcatacgg ccgccagagc ttccacttgg tcaggcagta 23400 gtttgaagtt cgcctttaga tcgttatcca cgtggtactt gtccatcagc gcgcgcgcag 23460 cctccatgcc cttctcccac gcagacacga tcggcacact cagcgggttc atcaccgtaa 23520 tttcactttc cgcttcgctg ggctcttcct cttcctcttg cgtccgcata ccacgcgcca 23580 ctgggtcgtc ttcattcagc cgccgcactg tgcgcttacc tcctttgcca tgcttgatta 23640 gcaccggtgg gttgctgaaa cccaccattt gtagcgccac atcttctctt tcttcctcgc 23700 tgtccacgat tacctctggt gatggcgggc gctcgggctt gggagaaggg cgcttctttt 23760 tcttcttggg cgcaatggcc aaatccgccg ccgaggtcga tggccgcggg ctgggtgtgc 23820 gcggcaccag cgcgtcttgt gatgagtctt cctcgtcctc ggactcgata cgccgcctca 23880 tccgcttttt tgggggcgcc cggggaggcg gcggcgacgg ggacggggac gacacgtcct 23940 ccatggttgg gggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt tcgcgctgct 24000 cctcttcccg actggccatt tccttctcct ataggcagaa aaagatcatg gagtcagtcg 24060 agaagaagga cagcctaacc gccccctctg agttcgccac caccgcctcc accgatgccg 24120 ccaacgcgcc taccaccttc cccgtcgagg cacccccgct tgaggaggag gaagtgatta 24180 tcgagcagga cccaggtttt gtaagcgaag acgacgagga ccgctcagta ccaacagagg 24240 ataaaaagca agaccaggac aacgcagagg caaacgagga acaagtcggg cggggggacg 24300 aaaggcatgg cgactaccta gatgtgggag acgacgtgct gttgaagcat ctgcagcgcc 24360 agtgcgccat tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc gccatagcgg 24420 atgtcagcct tgcctacgaa cgccacctat tctcaccgcg cgtacccccc aaacgccaag 24480 aaaacggcac atgcgagccc aacccgcgcc tcaacttcta ccccgtattt gccgtgccag 24540 aggtgcttgc cacctatcac atctttttcc aaaactgcaa gataccccta tcctgccgtg 24600 ccaaccgcag ccgagcggac aagcagctgg ccttgcggca gggcgctgtc atacctgata 24660 tcgcctcgct caacgaagtg ccaaaaatct ttgagggtct tggacgcgac gagaagcgcg 24720 cggcaaacgc tctgcaacag gaaaacagcg aaaatgaaag tcactctgga gtgttggtgg 24780 aactcgaggg tgacaacgcg cgcctagccg tactaaaacg cagcatcgag gtcacccact 24840 ttgcctaccc ggcacttaac ctacccccca aggtcatgag cacagtcatg agtgagctga 24900 tcgtgcgccg tgcgcagccc ctggagaggg atgcaaattt gcaagaacaa acagaggagg 24960 gcctacccgc agttggcgac gagcagctag cgcgctggct tcaaacgcgc gagcctgccg 25020 acttggagga gcgacgcaaa ctaatgatgg ccgcagtgct cgttaccgtg gagcttgagt 25080 gcatgcagcg gttctttgct gacccggaga tgcagcgcaa gctagaggaa acattgcact 25140 acacctttcg acagggctac gtacgccagg cctgcaagat ctccaacgtg gagctctgca 25200 acctggtctc ctaccttgga attttgcacg aaaaccgcct tgggcaaaac gtgcttcatt 25260 ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac ttatttctat 25320 gctacacctg gcagacggcc atgggcgttt ggcagcagtg cttggaggag tgcaacctca 25380 aggagctgca gaaactgcta aagcaaaact tgaaggacct atggacggcc ttcaacgagc 25440 gctccgtggc cgcgcacctg gcggacatca ttttccccga acgcctgctt aaaaccctgc 25500 aacagggtct gccagacttc accagtcaaa gcatgttgca gaactttagg aactttatcc 25560 tagagcgctc aggaatcttg cccgccacct gctgtgcact tcctagcgac tttgtgccca 25620 ttaagtaccg cgaatgccct ccgccgcttt ggggccactg ctaccttctg cagctagcca 25680 actaccttgc ctaccactct gacataatgg aagacgtgag cggtgacggt ctactggagt 25740 gtcactgtcg ctgcaaccta tgcaccccgc accgctccct ggtttgcaat tcgcagctgc 25800 ttaacgaaag tcaaattatc ggtacctttg agctgcaggg tccctcgcct gacgaaaagt 25860 ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac gtcggcttac cttcgcaaat 25920 ttgtacctga ggactaccac gcccacgaga ttaggttcta cgaagaccaa tcccgcccgc 25980 caaatgcgga gcttaccgcc tgcgtcatta cccagggcca cattcttggc caattgcaag 26040 ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg acggggggtt tacttggacc 26100 cccagtccgg cgaggagctc aacccaatcc ccccgccgcc gcagccctat cagcagcagc 26160 cgcgggccct tgcttcccag gatggcaccc aaaaagaagc tgcagctgcc gccgccaccc 26220 acggacgagg aggaatactg ggacagtcag gcagaggagg ttttggacga ggaggaggag 26280 gacatgatgg aagactggga gagcctagac gaggaagctt ccgaggtcga agaggtgtca 26340 gacgaaacac cgtcaccctc ggtcgcattc ccctcgccgg cgccccagaa atcggcaacc 26400 ggttccagca tggctacaac ctccgctcct caggcgccgc cggcactgcc cgttcgccga 26460 cccaaccgta gatgggacac cactggaacc agggccggta agtccaagca gccgccgccg 26520 ttagcccaag agcaacaaca gcgccaaggc taccgctcat ggcgcgggca caagaacgcc 26580 atagttgctt gcttgcaaga ctgtgggggc aacatctcct tcgcccgccg ctttcttctc 26640 taccatcacg gcgtggcctt cccccgtaac atcctgcatt actaccgtca tctctacagc 26700 ccatactgca ccggcggcag cggcagcggc agcaacagca gcggccacac agaagcaaag 26760 gcgaccggat agcaagactc tgacaaagcc caagaaatcc acagcggcgg cagcagcagg 26820 aggaggagcg ctgcgtctgg cgcccaacga acccgtatcg acccgcgagc ttagaaacag 26880 gatttttccc actctgtatg ctatatttca acagagcagg ggccaagaac aagagctgaa 26940 aataaaaaac aggtctctgc gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga 27000 tcagcttcgg cgcacgctgg aagacgcgga ggctctcttc agtaaatact gcgcgctgac 27060 tcttaaggac tagtttcgcg ccctttctca aatttaagcg cgaaaactac gtcatctcca 27120 gcggccacac ccggcgccag cacctgtcgt cagcgccatt tatgagcaag gaaattccca 27180 cgccctacat gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact 27240 actcaacccg aataaactac atgagcgcgg gaccccacat gatatcccgg gtcaacggaa 27300 tacgcgccca ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta 27360 ataaccttaa tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca 27420 ccactgtggt acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc 27480 agcttgcggg cggctttcgt cacagggtgc ggtcgcccgg gcagggtata actcacctga 27540 caatcagagg gcgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc 27600 gtccggacgg gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg 27660 caatcctaac tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactctgc 27720 aatttattga ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc 27780 actatccgga tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg 27840 actgaatgtt aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc 27900 gccacaagtg ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc 27960 atatcgaggg cccggcgcac ggcgtccggc ttaccgccca gggagagctt gcccgtagcc 28020 tgattcggga gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc 28080 tcactgtgat ttgcaactgt cctaaccctg gattacatca agatctttgt tgccatctct 28140 gtgctgagta taataaatac agaaattaaa atatactggg gctcctatcg ccatcctgta 28200 aacgccaccg tcttcacccg cccaagcaaa ccaaggcgaa ccttacctgg tacttttaac 28260 atctctccct ctgtgattta caacagtttc aacccagacg gagtgagtct acgagagaac 28320 ctctccgagc tcagctactc catcagaaaa aacaccaccc tccttacctg ccgggaacgt 28380 acgagtgcgt caccggccgc tgcaccacac ctaccgcctg accgtaaacc agactttttc 28440 cggacagacc tcaataactc tgtttaccag aacaggaggt gagcttagaa aacccttagg 28500 gtattaggcc aaaggcgcag ctactgtggg gtttatgaac aattcaagca actctacggg 28560 ctattctaat tcaggtttct ctagaatcgg ggttggggtt attctctgtc ttgtgattct 28620 ctttattctt atactaacgc ttctctgcct aaggctcgcc gcctgctgtg tgcacatttg 28680 catttattgt cagcttttta aacgctgggg tcgccaccca agatgattag gtacataatc 28740 ctaggtttac tcacccttgc gtcagcccac ggtaccaccc aaaaggtgga ttttaaggag 28800 ccagcctgta atgttacatt cgcagctgaa gctaatgagt gcaccactct tataaaatgc 28860 accacagaac atgaaaagct gcttattcgc cacaaaaaca aaattggcaa gtatgctgtt 28920 tatgctattt ggcagccagg tgacactaca gagtataatg ttacagtttt ccagggtaaa 28980 agtcataaaa cttttatgta tacttttcca ttttatgaaa tgtgcgacat taccatgtac 29040 atgagcaaac agtataagtt gtggccccca caaaattgtg tggaaaacac tggcactttc 29100 tgctgcactg ctatgctaat tacagtgctc gctttggtct gtaccctact ctatattaaa 29160 tacaaaagca gacgcagctt tattgaggaa aagaaaatgc cttaatttac taagttacaa 29220 agctaatgtc accactaact gctttactcg ctgcttgcaa aacaaattca aaaagttagc 29280 attataatta gaataggatt taaacccccc ggtcatttcc tgctcaatac cattcccctg 29340 aacaattgac tctatgtggg atatgctcca gcgctacaac cttgaagtca ggcttcctgg 29400 atgtcagcat ctgactttgg ccagcacctg tcccgcggat ttgttccagt ccaactacag 29460 cgacccaccc taacagagat gaccaacaca accaacgcgg ccgccgctac cggacttaca 29520 tctaccacaa atacacccca agtttctgcc tttgtcaata actgggataa cttgggcatg 29580 tggtggttct ccatagcgct tatgtttgta tgccttatta ttatgtggct catctgctgc 29640 ctaaagcgca aacgcgcccg accacccatc tatagtccca tcattgtgct acacccaaac 29700 aatgatggaa tccatagatt ggacggactg aaacacatgt tcttttctct tacagtatga 29760 ttaaatgaga catggccgtt cagctggtgg aaagtggcgg gggttctgtt caggcgggcg 29820 ggtctctgag gcttacttgc gccgcgagtg gtagaaccag tcggagctac ggaatggggt 29880 ggtttaggca agctcccggg aaagaacgcg aatttgtgag cggcattagc tggcggggcg 29940 attccactgg gtacgcagac tctgtaaagg gaaggtttac catcagccgc gataacgcaa 30000 agaacaccgt tgatctgcag atgaatagct tgagaccgga ggacaccgcc atctactact 30060 gtgcagctgc cgccggaagc acatggtatg ggactctgta tgaatacgac tactggggcc 30120 agggtacaca agttaccgta agcagcggct ctgggtccgg ctcgaccgga gtgcaggtgg 30180 aaaccatctc cccaggagac gggcgcacct tccccaagcg cggccagacc tgcgtggtgc 30240 actacaccgg gatgcttgaa gatggaaaga aatttgattc ctcccgggac agaaacaagc 30300 cctttaagtt tatgctaggc aagcaggagg tgatccgagg ctgggaagaa ggggttgccc 30360 agatgagtgt gggtcagaga gccaaactga ctatatctcc agattatgcc tatggtgcca 30420 ctgggcaccc aggcatcatc ccaccacatg ccactctcgt cttcgatgtg gagcttctaa 30480 aactgtaata aaaaaaaata ataaagcatc acttacttaa aatcagttag caaatttctg 30540 tccagtttat tcagcagcac ctccttgccc tcctcccagc tctggtattg cagcttcctc 30600 ctggctgcaa actttctcca caatctaaat ggaatgtcag tttcctcctg ttcctgtcca 30660 tccgcaccca ctatcttcat gttgttgcag atgaagcgcg caagaccgtc tgaagatacc 30720 ttcaaccccg tgtatccata tgacacggaa accggtcctc caactgtgcc ttttcttact 30780 cctccctttg tatcccccaa tgggtttcaa gagagtcccc ctggggtact ctctttgcgc 30840 ctatccgaac ctctagttac ctccaatggc atgcttgcgc tcaaaatggg caacggcctc 30900 tctctggacg aggccggcaa ccttacctcc caaaatgtaa ccactgtgag cccacctctc 30960 aaaaaaacca agtcaaacat aaacctggaa atatctgcac ccctcacagt tacctcagaa 31020 gccctaactg tggctgccgc cgcacctcta atggtcgcgg gcaacacact caccatgcaa 31080 tcacaggccc cgctaaccgt gcacgactcc aaacttagca ttgccaccca aggacccctc 31140 acagtgtcag aaggaaagct agccctgcaa acatcaggcc ccctcaccac caccgatagc 31200 agtaccctta ctatcactgc ctcaccccct ctaactactg ccactggtag cttgggcatt 31260 gacttgaaag agcccattta tacacaaaat ggaaaactag gactaaagta cggggctcct 31320 ttgcatgtaa cagacgacct aaacactttg accgtagcaa ctggtccagg tgtgactatt 31380 aataatactt ccttgcaaac taaagttact ggagccttgg gttttgattc acaaggcaat 31440 atgcaactta atgtagcagg aggactaagg attgattctc aaaacagacg ccttatactt 31500 gatgttagtt atccgtttga tgctcaaaac caactaaatc taagactagg acagggccct 31560 ctttttataa actcagccca caacttggat attaactaca acaaaggcct ttacttgttt 31620 acagcttcaa acaattccaa aaagcttgag gttaacctaa gcactgccaa ggggttgatg 31680 tttgacgcta cagccatagc cattaatgca ggagatgggc ttgaatttgg ttcacctaat 31740 gcaccaaaca caaatcccct caaaacaaaa attggccatg gcctagaatt tgattcaaac 31800 aaggctatgg ttcctaaact aggaactggc cttagttttg acagcacagg tgccattaca 31860 gtaggaaaca aaaataatga taagctaact ttgtggacca caccagctcc atctcctaac 31920 tgtagactaa atgcagagaa agatgctaaa ctcactttgg tcttaacaaa atgtggcagt 31980 caaatacttg ctacagtttc agttttggct gttaaaggca gtttggctcc aatatctgga 32040 acagttcaaa gtgctcatct tattataaga tttgacgaaa atggagtgct actaaacaat 32100 tccttcctgg acccagaata ttggaacttt agaaatggag atcttactga aggcacagcc 32160 tatacaaacg ctgttggatt tatgcctaac ctatcagctt atccaaaatc tcacggtaaa 32220 actgccaaaa gtaacattgt cagtcaagtt tacttaaacg gagacaaaac taaacctgta 32280 acactaacca ttacactaaa cggtacacag gaaacaggag acacaactga gatgtggcat 32340 gaaggcctag aagaggcctc tcgcttgtac tttggggaga ggaacgtcaa aggcatgttt 32400 gaggtgctgg agcccctgca tgctatgatg gaacgcggtc cccagaccct gaaggaaacg 32460 tcctttaatc aggcatatgg tcgagattta atggaggcac aagaatggtg ccgaaagtac 32520 atgaaatcag ggaacgtcaa ggacctcacc caagcctggg acctctacta tcacgtgttc 32580 agacgaatct caaagcagcc aagtgcatac tctatgtcat tttcatggga ctggtctggc 32640 cacaactaca ttaatgaaat atttgccaca tcctcttaca ctttttcata cattgcccaa 32700 gaataaagaa tcgtttgtgt tatgtttcaa cgtgtttatt tttcaattgc agaaaatttc 32760 aagtcatttt tcattcagta gtatagcccc accaccacat agcttataca gatcaccgta 32820 ccttaatcaa acctacatgg gggtagagtc ataatcgtgc atcaggatag ggcggtggtg 32880 ctgcagcagc gcgcgaataa actgctgccg ccgccgctcc gtcctgcagg aatacaacat 32940 ggcagtggtc tcctcagcga tgattcgcac cgcccgcagc ataaggcgcc ttgtcctccg 33000 ggcacagcag cgcaccctga tctcacttaa atcagcacag taactgcagc acagcaccac 33060 aatattgttc aaaatcccac agtgcaaggc gctgtatcca aagctcatgg cggggaccac 33120 agaacccacg tggccatcat accacaagcg caggtagatt aagtggcgac ccctcataaa 33180 cacgctggac ataaacatta cctcttttgg catgttgtaa ttcaccacct cccggtacca 33240 tataaacctc tgattaaaca tggcgccatc caccaccatc ctaaaccagc tggccaaaac 33300 ctgcccgccg gctatacact gcagggaacc gggactggaa caatgacagt ggagagccca 33360 ggactcgtaa ccatggatca tcatgctcgt catgatatca atgttggcac aacacaggca 33420 cacgtgcata cacttcctca ggattacaag ctcctcccgc gttagaacca tatcccaggg 33480 aacaacccat tcctgaatca gcgtaaatcc cacactgcag ggaagacctc gcacgtaact 33540 cacgttgtgc attgtcaaag tgttacattc gggcagcagc ggatgatcct ccagtatggt 33600 agcgcgggtt tctgtctcaa aaggaggtag acgatcccta ctgtacggag tgcgccgaga 33660 caaccgagat cgtgttggtc gtagtgtcat gccaaatgga acgccggacg tagtcatatt 33720 tcctgaagca aaaccaggtg cgggcgtgac aaacagatct gcgtctccgg tctcgccgct 33780 tagatcgctc tgtgtagtag ttgtagtata tccactctct caaagcatcc aggcgccccc 33840 tggcttcggg ttctatgtaa actccttcat gcgccgctgc cctgataaca tccaccaccg 33900 cagaataagc cacacccagc caacctacac attcgttctg cgagtcacac acgggaggag 33960 cgggaagagc tggaagaacc atgttttttt ttttattcca aaagattatc caaaacctca 34020 aaatgaagat ctattaagtg aacgcgctcc cctccggtgg cgtggtcaaa ctctacagcc 34080 aaagaacaga taatggcatt tgtaagatgt tgcacaatgg cttccaaaag gcaaacggcc 34140 ctcacgtcca agtggacgta aaggctaaac ccttcagggt gaatctcctc tataaacatt 34200 ccagcacctt caaccatgcc caaataattc tcatctcgcc accttctcaa tatatctcta 34260 agcaaatccc gaatattaag tccggccatt gtaaaaatct gctccagagc gccctccacc 34320 ttcagcctca agcagcgaat catgattgca aaaattcagg ttcctcacag acctgtataa 34380 gattcaaaag cggaacatta acaaaaatac cgcgatcccg taggtccctt cgcagggcca 34440 gctgaacata atcgtgcagg tctgcacgga ccagcgcggc cacttccccg ccaggaacca 34500 tgacaaaaga acccacactg attatgacac gcatactcgg agctatgcta accagcgtag 34560 ccccgatgta agcttgttgc atgggcggcg atataaaatg caaggtgctg ctcaaaaaat 34620 caggcaaagc ctcgcgcaaa aaagaaagca catcgtagtc atgctcatgc agataaaggc 34680 aggtaagctc cggaaccacc acagaaaaag acaccatttt tctctcaaac atgtctgcgg 34740 gtttctgcat aaacacaaaa taaaataaca aaaaaacatt taaacattag aagcctgtct 34800 tacaacagga aaaacaaccc ttataagcat aagacggact acggccatgc cggcgtgacc 34860 gtaaaaaaac tggtcaccgt gattaaaaag caccaccgac agctcctcgg tcatgtccgg 34920 agtcataatg taagactcgg taaacacatc aggttgattc acatcggtca gtgctaaaaa 34980 gcgaccgaaa tagcccgggg gaatacatac ccgcaggcgt agagacaaca ttacagcccc 35040 cataggaggt ataacaaaat taataggaga gaaaaacaca taaacacctg aaaaaccctc 35100 ctgcctaggc aaaatagcac cctcccgctc cagaacaaca tacagcgctt ccacagcggc 35160 agccataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac 35220 acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc gagtatatat 35280 aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg 35340 aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg tcacttccgt 35400 tttcccacgt tacgtcactt cccattttaa gaaaactaca attcccaaca catacaagtt 35460 actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac 35520 tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat tgatgatg 35578 <210> 27 <211> 36900 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO199) <400> 27 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattaaac cgtattaccg ccatgcatta gttattaata 480 gtaatcaatt acggggtcat tagttcttaa tggagtgcct cgtgaggctc cggtgcccgt 540 cagtgggcag agcgcacatc gcccacagtc cccgagaagt tggggggagg ggtcggcaat 600 tgaaccggtg cctagagaag gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg 660 ctccgccttt ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac 720 gttctttttc gcaacgggtt tgccgccaga acacaggtaa gtgccgtgtg tggttcccgc 780 gggcctggcc tctttacggg ttatggccct tgcgtgcctt gaattacttc cacctggctg 840 cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag ttcgaggcct 900 tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcctgg gcgctggggc 960 cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga taagtctcta 1020 gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga tagtcttgta 1080 aatgcgggcc aagatctgca cactggtatt tcggtttttg gggccgcggg cggcgacggg 1140 gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg gccaccgaga 1200 atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct cgcgccgccg 1260 tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc gtgagcggaa 1320 agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg gcgctcggga 1380 gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc agccgtcgct 1440 tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt ctcgagcttt 1500 tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt tccccacact 1560 gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc cttggaattt 1620 gccctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt tcaaagtttt 1680 tttcttccat ttcaggtgtc gtgacgctag cgctaccgga ctcagatctc gagctcaagc 1740 ttcgaattct gcagtcgacg gtaccggatc catggaagac gccaaaaaca taaagaaagg 1800 cccggcgcca ttctatccgc tggaagatgg aaccgctgga gagcaactgc ataaggctat 1860 gaagagatac gccctggttc ctggaacaat tgcttttaca gatgcacata tcgaggtgga 1920 catcacttac gctgagtact tcgaaatgtc cgttcggttg gcagaagcta tgaaacgata 1980 tgggctgaat acaaatcaca gaatcgtcgt atgcagtgaa aactctcttc aattctttat 2040 gccggtgttg ggcgcgttat ttatcggagt tgcagttgcg cccgcgaacg acatttataa 2100 tgaacgtgaa ttgctcaaca gtatgggcat ttcgcagcct accgtggtgt tcgtttccaa 2160 aaaggggttg caaaaaattt tgaacgtgca aaaaaagctc ccaatcatcc aaaaaattat 2220 tatcatggat tctaaaacgg attaccaggg atttcagtcg atgtacacgt tcgtcacatc 2280 tcatctacct cccggtttta atgaatacga ttttgtgcca gagtccttcg atagggacaa 2340 gacaattgca ctgatcatga actcctctgg atctactggt ctgcctaaag gtgtcgctct 2400 gcctcataga actgcctgcg tgagattctc gcatgccaga gatcctattt ttggcaatca 2460 aatcattccg gatactgcga ttttaagtgt tgttccattc catcacggtt ttggaatgtt 2520 tactacactc ggatatttga tatgtggatt tcgagtcgtc ttaatgtata gatttgaaga 2580 agagctgttt ctgaggagcc ttcaggatta caagattcaa agtgcgctgc tggtgccaac 2640 cctattctcc ttcttcgcca aaagcactct gattgacaaa tacgatttat ctaatttaca 2700 cgaaattgct tctggtggcg ctcccctctc taaggaagtc ggggaagcgg ttgccaagag 2760 gttccatctg ccaggtatca ggcaaggata tgggctcact gagactacat cagctattct 2820 gattacaccc gagggggatg ataaaccggg cgcggtcggt aaagttgttc cattttttga 2880 agcgaaggtt gtggatctgg ataccgggaa aacgctgggc gttaatcaaa gaggcgaact 2940 gtgtgtgaga ggtcctatga ttatgtccgg ttatgtaaac aatccggaag cgaccaacgc 3000 cttgattgac aaggatggat ggctacattc tggagacata gcttactggg acgaagacga 3060 acacttcttc atcgttgacc gcctgaagtc tctgattaag tacaaaggct atcaggtggc 3120 tcccgctgaa ttggaatcca tcttgctcca acaccccaac atcttcgacg caggtgtcgc 3180 aggtcttccc gacgatgacg ccggtgaact tcccgccgcc gttgttgttt tggagcacgg 3240 aaagacgatg acggaaaaag agatcgtgga ttacgtcgcc agtcaagtaa caaccgcgaa 3300 aaagttgcgc ggaggagttg tgtttgtgga cgaagtaccg aaaggtctta ccggaaaact 3360 cgacgcaaga aaaatcagag agatcctcat aaaggccaag aagggcggaa agatcgccgt 3420 ggcagccgca gccaccatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat 3480 cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga 3540 gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc 3600 cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta 3660 ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca 3720 ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt 3780 cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg 3840 caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc 3900 cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg 3960 cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct 4020 gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa 4080 gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga 4140 cgagctgtac aagtaaagcg actctagatc ataatcagcc ataccacatt tgtagaggtt 4200 ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca 4260 attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc 4320 acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc 4380 atcaatgtaa gtttaaacgg cgcgcctgaa atgtgtgggc gtggcttaag ggtgggaaag 4440 aatatataag gtgggggtct tatgtagttt tgtatctgtt ttgcagcagc cgccgccgcc 4500 atgagcacca actcgtttga tggaagcatt gtgagctcat atttgacaac gcgcatgccc 4560 ccatgggccg gggtgcgtca gaatgtgatg ggctccagca ttgatggtcg ccccgtcctg 4620 cccgcaaact ctactacctt gacctacgag accgtgtctg gaacgccgtt ggagactgca 4680 gcctccgccg ccgcttcagc cgctgcagcc accgcccgcg ggattgtgac tgactttgct 4740 ttcctgagcc cgcttgcaag cagtgcagct tcccgttcat ccgcccgcga tgacaagttg 4800 acggctcttt tggcacaatt ggattctttg acccgggaac ttaatgtcgt ttctcagcag 4860 ctgttggatc tgcgccagca ggtttctgcc ctgaaggctt cctcccctcc caatgcggtt 4920 taaaacacaa cttttctata caaagttgta aataaaaaac cagactctgt ttggatttgg 4980 atcaagctaa gtgtcttgct gtctttattt aggggttttg cgcgcgcggt aggcccggga 5040 ccagcggtct cggtcgttga gggtcctgtg tattttttcc aggacgtggt aaaggtgact 5100 ctggatgttc agatacatgg gcataagccc gtctctgggg tggaggtagc accactgcag 5160 agcttcatgc tgcggggtgg tgttgtagat gatccagtcg tagcaggagc gctgggcgtg 5220 gtgcctaaaa atgtctttca gtagcaagct gattgccagg ggcaggccct tggtgtaagt 5280 gtttacaaag cggttaagct gggatgggtg catacgtggg gatatgagat gcatcttgga 5340 ctgtattttt aggttggcta tgttcccagc catatccctc cggggattca tgttgtgcag 5400 aaccaccagc acagtgtatc cggtgcactt gggaaatttg tcatgtagct tagaaggaaa 5460 tgcgtggaag aacttggaga cgcccttgtg acctccaaga ttttccatgc attcgtccat 5520 aatgatggca atgggcccac gggcggcggc ctgggcgaag atatttctgg gatcactaac 5580 gtcatagttg tgttccagga tgagatcgtc ataggccatt tttacaaagc gcgggcggag 5640 ggtgccagac tgcggtataa tggttccatc cggcccaggg gcgtagttac cctcacagat 5700 ttgcatttcc cacgctttga gttcagatgg ggggatcatg tctacctgcg gggcgatgaa 5760 gaaaacggtt tccggggtag gggagatcag ctgggaagaa agcaggttcc tgagcagctg 5820 cgacttaccg cagccggtgg gcccgtaaat cacacctatt accggctgca actggtagtt 5880 aagagagctg cagctgccgt catccctgag caggggggcc acttcgttaa gcatgtccct 5940 gactcgcatg ttttccctga ccaaatccgc cagaaggcgc tcgccgccca gcgatagcag 6000 ttcttgcaag gaagcaaagt ttttcaacgg tttgagaccg tccgccgtag gcatgctttt 6060 gagcgtttga ccaagcagtt ccaggcggtc ccacagctcg gtcacctgct ctacggcatc 6120 tcgatccagc atatctcctc gtttcgcggg ttggggcggc tttcgctgta cggcagtagt 6180 cggtgctcgt ccagacgggc cagggtcatg tctttccacg ggcgcagggt cctcgtcagc 6240 gtagtctggg tcacggtgaa ggggtgcgct ccgggctgcg cgctggccag ggtgcgcttg 6300 aggctggtcc tgctggtgct gaagcgctgc cggtcttcgc cctgcgcgtc ggccaggtag 6360 catttgacca tggtgtcata gtccagcccc tccgcggcgt ggcccttggc gcgcagcttg 6420 cccttggagg aggcgccgca cgaggggcag tgcagacttt tgagggcgta gagcttgggc 6480 gcgagaaata ccgattccgg ggagtaggca tccgcgccgc aggccccgca gacggtctcg 6540 cattccacga gccaggtgag ctctggccgt tcggggtcaa aaaccaggtt tcccccatgc 6600 tttttgatgc gtttcttacc tctggtttcc atgagccggt gtccacgctc ggtgacgaaa 6660 aggctgtccg tgtccccgta tacagacttg agaggcctgt cctcgagcgg tgttccgcgg 6720 tcctcctcgt atagaaactc ggaccactct gagacaaagg ctcgcgtcca ggccagcacg 6780 aaggaggcta agtgggaggg gtagcggtcg ttgtccacta gggggtccac tcgctccagg 6840 gtgtgaagac acatgtcgcc ctcttcggca tcaaggaagg tgattggttt gtaggtgtag 6900 gccacgtgac cgggtgttcc tgaagggggg ctataaaagg gggtgggggc gcgttcgtcc 6960 tcactctctt ccgcatcgct gtctgcgagg gccagctgtt ggggtgagta ctccctctga 7020 aaagcgggca tgacttctgc gctaagattg tcagtttcca aaaacgagga ggatttgata 7080 ttcacctggc ccgcggtgat gcctttgagg gtggccgcat ccatctggtc agaaaagaca 7140 atctttttgt tgtcaagctt ggtggcaaac gacccgtaga gggcgttgga cagcaacttg 7200 gcgatggagc gcagggtttg gtttttgtcg cgatcggcgc gctccttggc cgcgatgttt 7260 agctgcacgt attcgcgcgc aacgcaccgc cattcgggaa agacggtggt gcgctcgtcg 7320 ggcaccaggt gcacgcgcca accgcggttg tgcagggtga caaggtcaac gctggtggct 7380 acctctccgc gtaggcgctc gttggtccag cagaggcggc cgcccttgcg cgagcagaat 7440 ggcggtaggg ggtctagctg cgtctcgtcc ggggggtctg cgtccacggt aaagaccccg 7500 ggcagcaggc gcgcgtcgaa gtagtctatc ttgcatcctt gcaagtctag cgcctgctgc 7560 catgcgcggg cggcaagcgc gcgctcgtat gggttgagtg ggggacccca tggcatgggg 7620 tgggtgagcg cggaggcgta catgccgcaa atgtcgtaaa cgtagagggg ctctctgagt 7680 attccaagat atgtagggta gcatcttcca ccgcggatgc tggcgcgcac gtaatcgtat 7740 agttcgtgcg agggagcgag gaggtcggga ccgaggttgc tacgggcggg ctgctctgct 7800 cggaagacta tctgcctgaa gatggcatgt gagttggatg atatggttgg acgctggaag 7860 acgttgaagc tggcgtctgt gagacctacc gcgtcacgca cgaaggaggc gtaggagtcg 7920 cgcagcttgt tgaccagctc ggcggtgacc tgcacgtcta gggcgcagta gtccagggtt 7980 tccttgatga tgtcatactt atcctgtccc ttttttttcc acagctcgcg gttgaggaca 8040 aactcttcgc ggtctttcca gtactcttgg atcggaaacc cgtcggcctc cgaacggtaa 8100 gagcctagca tgtagaactg gttgacggcc tggtaggcgc agcatccctt ttctacgggt 8160 agcgcgtatg cctgcgcggc cttccggagc gaggtgtggg tgagcgcaaa ggtgtccctg 8220 accatgactt tgaggtactg gtatttgaag tcagtgtcgt cgcatccgcc ctgctcccag 8280 agcaaaaagt ccgtgcgctt tttggaacgc ggatttggca gggcgaaggt gacatcgttg 8340 aagagtatct ttcccgcgcg aggcataaag ttgcgtgtga tgcggaaggg tcccggcacc 8400 tcggaacggt tgttaattac ctgggcggcg agcacgatct cgtcaaagcc gttgatgttg 8460 tggcccacaa tgtaaagttc caagaagcgc gggatgccct tgatggaagg caatttttta 8520 agttcctcgt aggtgagctc ttcaggggag ctgagcccgt gctctgaaag ggcccagtct 8580 gcaagatgag ggttggaagc gacgaatgag ctccacaggt cacgggccat tagcatttgc 8640 aggtggtcgc gaaaggtcct aaactggcga cctatggcca ttttttctgg ggtgatgcag 8700 tagaaggtaa gcgggtcttg ttcccagcgg tcccatccaa ggttcgcggc taggtctcgc 8760 gcggcagtca ctagaggctc atctccgccg aacttcatga ccagcatgaa gggcacgagc 8820 tgcttcccaa aggcccccat ccaagtatag gtctctacat cgtaggtgac aaagagacgc 8880 tcggtgcgag gatgcgagcc gatcgggaag aactggatct cccgccacca attggaggag 8940 tggctattga tgtggtgaaa gtagaagtcc ctgcgacggg ccgaacactc gtgctggctt 9000 ttgtaaaaac gtgcgcagta ctggcagcgg tgcacgggct gtacatcctg cacgaggttg 9060 acctgacgac cgcgcacaag gaagcagagt gggaatttga gcccctcgcc tggcgggttt 9120 ggctggtggt cttctacttc ggctgcttgt ccttgaccgt ctggctgctc gaggggagtt 9180 acggtggatc ggaccaccac gccgcgcgag cccaaagtcc agatgtccgc gcgcggcggt 9240 cggagcttga tgacaacatc gcgcagatgg gagctgtcca tggtctggag ctcccgcggc 9300 gtcaggtcag gcgggagctc ctgcaggttt acctcgcata gacgggtcag ggcgcgggct 9360 agatccaggt gatacctaat ttccaggggc tggttggtgg cggcgtcgat ggcttgcaag 9420 aggccgcatc cccgcggcgc gactacggta ccgcgcggcg ggcggtgggc cgcgggggtg 9480 tccttggatg atgcatctaa aagcggtgac gcgggcgagc ccccggaggt agggggggct 9540 ccggacccgc cgggagaggg ggcaggggca cgtcggcgcc gcgcgcgggc aggagctggt 9600 gctgcgcgcg taggttgctg gcgaacgcga cgacgcggcg gttgatctcc tgaatctggc 9660 gcctctgcgt gaagacgacg ggcccggtga gcttgaacct gaaagagagt tcgacagaat 9720 caatttcggt gtcgttgacg gcggcctggc gcaaaatctc ctgcacgtct cctgagttgt 9780 cttgataggc gatctcggcc atgaactgct cgatctcttc ctcctggaga tctccgcgtc 9840 cggctcgctc cacggtggcg gcgaggtcgt tggaaatgcg ggccatgagc tgcgagaagg 9900 cgttgaggcc tccctcgttc cagacgcggc tgtagaccac gcccccttcg gcatcgcggg 9960 cgcgcatgac cacctgcgcg agattgagct ccacgtgccg ggcgaagacg gcgtagtttc 10020 gcaggcgctg aaagaggtag ttgagggtgg tggcggtgtg ttctgccacg aagaagtaca 10080 taacccagcg tcgcaacgtg gattcgttga tatcccccaa ggcctcaagg cgctccatgg 10140 cctcgtagaa gtccacggcg aagttgaaaa actgggagtt gcgcgccgac acggttaact 10200 cctcctccag aagacggatg agctcggcga cagtgtcgcg cacctcgcgc tcaaaggcta 10260 caggggcctc ttcttcttct tcaatctcct cttccataag ggcctcccct tcttcttctt 10320 ctggcggcgg tgggggaggg gggacacggc ggcgacgacg gcgcaccggg aggcggtcga 10380 caaagcgctc gatcatctcc ccgcggcgac ggcgcatggt ctcggtgacg gcgcggccgt 10440 tctcgcgggg gcgcagttgg aagacgccgc ccgtcatgtc ccggttatgg gttggcgggg 10500 ggctgccatg cggcagggat acggcgctaa cgatgcatct caacaattgt tgtgtaggta 10560 ctccgccgcc gagggacctg agcgagtccg catcgaccgg atcggaaaac ctctcgagaa 10620 aggcgtctaa ccagtcacag tcgcaaggta ggctgagcac cgtggcgggc ggcagcgggc 10680 ggcggtcggg gttgtttctg gcggaggtgc tgctgatgat gtaattaaag taggcggtct 10740 tgagacggcg gatggtcgac agaagcacca tgtccttggg tccggcctgc tgaatgcgca 10800 ggcggtcggc catgccccag gcttcgtttt gacatcggcg caggtctttg tagtagtctt 10860 gcatgagcct ttctaccggc acttcttctt ctccttcctc ttgtcctgca tctcttgcat 10920 ctatcgctgc ggcggcggcg gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg 10980 tgaccccgaa gcccctcatc ggctgaagca gggctaggtc ggcgacaacg cgctcggcta 11040 atatggcctg ctgcacctgc gtgagggtag actggaagtc atccatgtcc acaaagcggt 11100 ggtatgcgcc cgtgttgatg gtgtaagtgc agttggccat aacggaccag ttaacggtct 11160 ggtgacccgg ctgcgagagc tcggtgtacc tgagacgcga gtaagccctc gagtcaaata 11220 cgtagtcgtt gcaagtccgc accaggtact ggtatcccac caaaaagtgc ggcggcggct 11280 ggcggtagag gggccagcgt agggtggccg gggctccggg ggcgagatct tccaacataa 11340 ggcgatgata tccgtagatg tacctggaca tccaggtgat gccggcggcg gtggtggagg 11400 cgcgcggaaa gtcgcggacg cggttccaga tgttgcgcag cggcaaaaag tgctccatgg 11460 tcgggacgct ctggccggtc aggcgcgcgc aatcgttgac gctctagacc gtgcaaaagg 11520 agagcctgta agcgggcact cttccgtggt ctggtggata aattcgcaag ggtatcatgg 11580 cggacgaccg gggttcgagc cccgtatccg gccgtccgcc gtgatccatg cggttaccgc 11640 ccgcgtgtcg aacccaggtg tgcgacgtca gacaacgggg gagtgctcct tttggcttcc 11700 ttccaggcgc ggcggctgct gcgctagctt ttttggccac tggccgcgcg cagcgtaagc 11760 ggttaggctg gaaagcgaaa gcattaagtg gctcgctccc tgtagccgga gggttatttt 11820 ccaagggttg agtcgcggga cccccggttc gagtctcgga ccggccggac tgcggcgaac 11880 gggggtttgc ctccccgtca tgcaagaccc cgcttgcaaa ttcctccgga aacagggacg 11940 agcccctttt ttgcttttcc cagatgcatc cggtgctgcg gcagatgcgc ccccctcctc 12000 agcagcggca agagcaagag cagcggcaga catgcagggc accctcccct cctcctaccg 12060 cgtcaggagg ggcgacatcc gcggttgacg cggcagcaga tggtgattac gaacccccgc 12120 ggcgccgggc ccggcactac ctggacttgg aggagggcga gggcctggcg cggctaggag 12180 cgccctctcc tgagcggcac ccaagggtgc agctgaagcg tgatacgcgt gaggcgtacg 12240 tgccgcggca gaacctgttt cgcgaccgcg agggagagga gcccgaggag atgcgggatc 12300 gaaagttcca cgcagggcgc gagctgcggc atggcctgaa tcgcgagcgg ttgctgcgcg 12360 aggaggactt tgagcccgac gcgcgaaccg ggattagtcc cgcgcgcgca cacgtggcgg 12420 ccgccgacct ggtaaccgca tacgagcaga cggtgaacca ggagattaac tttcaaaaaa 12480 gctttaacaa ccacgtgcgt acgcttgtgg cgcgcgagga ggtggctata ggactgatgc 12540 atctgtggga ctttgtaagc gcgctggagc aaaacccaaa tagcaagccg ctcatggcgc 12600 agctgttcct tatagtgcag cacagcaggg acaacgaggc attcagggat gcgctgctaa 12660 acatagtaga gcccgagggc cgctggctgc tcgatttgat aaacatcctg cagagcatag 12720 tggtgcagga gcgcagcttg agcctggctg acaaggtggc cgccatcaac tattccatgc 12780 ttagcctggg caagttttac gcccgcaaga tataccatac cccttacgtt cccatagaca 12840 aggaggtaaa gatcgagggg ttctacatgc gcatggcgct gaaggtgctt accttgagcg 12900 acgacctggg cgtttatcgc aacgagcgca tccacaaggc cgtgagcgtg agccggcggc 12960 gcgagctcag cgaccgcgag ctgatgcaca gcctgcaaag ggccctggct ggcacgggca 13020 gcggcgatag agaggccgag tcctactttg acgcgggcgc tgacctgcgc tgggccccaa 13080 gccgacgcgc cctggaggca gctggggccg gacctgggct ggcggtggca cccgcgcgcg 13140 ctggcaacgt cggcggcgtg gaggaatatg acgaggacga tgagtacgag ccagaggacg 13200 gcgagtacta agcggtgatg tttctgatca gatgatgcaa gacgcaacgg acccggcggt 13260 gcgggcggcg ctgcagagcc agccgtccgg ccttaactcc acggacgact ggcgccaggt 13320 catggaccgc atcatgtcgc tgactgcgcg caatcctgac gcgttccggc agcagccgca 13380 ggccaaccgg ctctccgcaa ttctggaagc ggtggtcccg gcgcgcgcaa accccacgca 13440 cgagaaggtg ctggcgatcg taaacgcgct ggccgaaaac agggccatcc ggcccgacga 13500 ggccggcctg gtctacgacg cgctgcttca gcgcgtggct cgttacaaca gcggcaacgt 13560 gcagaccaac ctggaccggc tggtggggga tgtgcgcgag gccgtggcgc agcgtgagcg 13620 cgcgcagcag cagggcaacc tgggctccat ggttgcacta aacgccttcc tgagtacaca 13680 gcccgccaac gtgccgcggg gacaggagga ctacaccaac tttgtgagcg cactgcggct 13740 aatggtgact gagacaccgc aaagtgaggt gtaccagtct gggccagact attttttcca 13800 gaccagtaga caaggcctgc agaccgtaaa cctgagccag gctttcaaaa acttgcaggg 13860 gctgtggggg gtgcgggctc ccacaggcga ccgcgcgacc gtgtctagct tgctgacgcc 13920 caactcgcgc ctgttgctgc tgctaatagc gcccttcacg gacagtggca gcgtgtcccg 13980 ggacacatac ctaggtcact tgctgacact gtaccgcgag gccataggtc aggcgcatgt 14040 ggacgagcat actttccagg agattacaag tgtcagccgc gcgctggggc aggaggacac 14100 gggcagcctg gaggcaaccc taaactacct gctgaccaac cggcggcaga agatcccctc 14160 gttgcacagt ttaaacagcg aggaggagcg cattttgcgc tacgtgcagc agagcgtgag 14220 ccttaacctg atgcgcgacg gggtaacgcc cagcgtggcg ctggacatga ccgcgcgcaa 14280 catggaaccg ggcatgtatg cctcaaaccg gccgtttatc aaccgcctaa tggactactt 14340 gcatcgcgcg gccgccgtga accccgagta tttcaccaat gccatcttga acccgcactg 14400 gctaccgccc cctggtttct acaccggggg attcgaggtg cccgagggta acgatggatt 14460 cctctgggac gacatagacg acagcgtgtt ttccccgcaa ccgcagaccc tgctagagtt 14520 gcaacagcgc gagcaggcag aggcggcgct gcgaaaggaa agcttccgca ggccaagcag 14580 cttgtccgat ctaggcgctg cggccccgcg gtcagatgct agtagcccat ttccaagctt 14640 gatagggtct cttaccagca ctcgcaccac ccgcccgcgc ctgctgggcg aggaggagta 14700 cctaaacaac tcgctgctgc agccgcagcg cgaaaaaaac ctgcctccgg catttcccaa 14760 caacgggata gagagcctag tggacaagat gagtagatgg aagacgtacg cgcaggagca 14820 cagggacgtg ccaggcccgc gcccgcccac ccgtcgtcaa aggcacgacc gtcagcgggg 14880 tctggtgtgg gaggacgatg actcggcaga cgacagcagc gtcctggatt tgggagggag 14940 tggcaacccg tttgcgcacc ttcgccccag gctggggaga atgttttaaa aaaaaaaaaa 15000 aagcatgatg caaaataaaa aactcaccaa ggccatggca ccgagcgttg gttttcttgt 15060 attcccctta gtatgcggcg cgcggcgatg tatgaggaag gtcctcctcc ctcctacgag 15120 agtgtggtga gcgcggcgcc agtggcggcg gcgctgggtt ctcccttcga tgctcccctg 15180 gacccgccgt ttgtgcctcc gcggtacctg cggcctaccg gggggagaaa cagcatccgt 15240 tactctgagt tggcacccct attcgacacc acccgtgtgt acctggtgga caacaagtca 15300 acggatgtgg catccctgaa ctaccagaac gaccacagca actttctgac cacggtcatt 15360 caaaacaatg actacagccc gggggaggca agcacacaga ccatcaatct tgacgaccgg 15420 tcgcactggg gcggcgacct gaaaaccatc ctgcatacca acatgccaaa tgtgaacgag 15480 ttcatgttta ccaataagtt taaggcgcgg gtgatggtgt cgcgcttgcc tactaaggac 15540 aatcaggtgg agctgaaata cgagtgggtg gagttcacgc tgcccgaggg caactactcc 15600 gagaccatga ccatagacct tatgaacaac gcgatcgtgg agcactactt gaaagtgggc 15660 agacagaacg gggttctgga aagcgacatc ggggtaaagt ttgacacccg caacttcaga 15720 ctggggtttg accccgtcac tggtcttgtc atgcctgggg tatatacaaa cgaagccttc 15780 catccagaca tcattttgct gccaggatgc ggggtggact tcacccacag ccgcctgagc 15840 aacttgttgg gcatccgcaa gcggcaaccc ttccaggagg gctttaggat cacctacgat 15900 gatctggagg gtggtaacat tcccgcactg ttggatgtgg acgcctacca ggcgagcttg 15960 aaagatgaca ccgaacaggg cgggggtggc gcaggcggca gcaacagcag tggcagcggc 16020 gcggaagaga actccaacgc ggcagccgcg gcaatgcagc cggtggagga catgaacgat 16080 catgccattc gcggcgacac ctttgccaca cgggctgagg agaagcgcgc tgaggccgaa 16140 gcagcggccg aagctgccgc ccccgctgcg caacccgagg tcgagaagcc tcagaagaaa 16200 ccggtgatca aacccctgac agaggacagc aagaaacgca gttacaacct aataagcaat 16260 gacagcacct tcacccagta ccgcagctgg taccttgcat acaactacgg cgaccctcag 16320 accggaatcc gctcatggac cctgctttgc actcctgacg taacctgcgg ctcggagcag 16380 gtctactggt cgttgccaga catgatgcaa gaccccgtga ccttccgctc cacgcgccag 16440 atcagcaact ttccggtggt gggcgccgag ctgttgcccg tgcactccaa gagcttctac 16500 aacgaccagg ccgtctactc ccaactcatc cgccagttta cctctctgac ccacgtgttc 16560 aatcgctttc ccgagaacca gattttggcg cgcccgccag cccccaccat caccaccgtc 16620 agtgaaaacg ttcctgctct cacagatcac gggacgctac cgctgcgcaa cagcatcgga 16680 ggagtccagc gagtgaccat tactgacgcc agacgccgca cctgccccta cgtttacaag 16740 gccctgggca tagtctcgcc gcgcgtccta tcgagccgca ctttttgagc aagcatgtcc 16800 atccttatat cgcccagcaa taacacaggc tggggcctgc gcttcccaag caagatgttt 16860 ggcggggcca agaagcgctc cgaccaacac ccagtgcgcg tgcgcgggca ctaccgcgcg 16920 ccctggggcg cgcacaaacg cggccgcact gggcgcacca ccgtcgatga cgccatcgac 16980 gcggtggtgg aggaggcgcg caactacacg cccacgccgc caccagtgtc cacagtggac 17040 gcggccattc agaccgtggt gcgcggagcc cggcgctatg ctaaaatgaa gagacggcgg 17100 aggcgcgtag cacgtcgcca ccgccgccga cccggcactg ccgcccaacg cgcggcggcg 17160 gccctgctta accgcgcacg tcgcaccggc cgacgggcgg ccatgcgggc cgctcgaagg 17220 ctggccgcgg gtattgtcac tgtgcccccc aggtccaggc gacgagcggc cgccgcagca 17280 gccgcggcca ttagtgctat gactcagggt cgcaggggca acgtgtattg ggtgcgcgac 17340 tcggttagcg gcctgcgcgt gcccgtgcgc acccgccccc cgcgcaacta gattgcaaga 17400 aaaaactact tagactcgta ctgttgtatg tatccagcgg cggcggcgcg caacgaagct 17460 atgtccaagc gcaaaatcaa agaagagatg ctccaggtca tcgcgccgga gatctatggc 17520 cccccgaaga aggaagagca ggattacaag ccccgaaagc taaagcgggt caaaaagaaa 17580 aagaaagatg atgatgatga acttgacgac gaggtggaac tgctgcacgc taccgcgccc 17640 aggcgacggg tacagtggaa aggtcgacgc gtaaaacgtg ttttgcgacc cggcaccacc 17700 gtagtcttta cgcccggtga gcgctccacc cgcacctaca agcgcgtgta tgatgaggtg 17760 tacggcgacg aggacctgct tgagcaggcc aacgagcgcc tcggggagtt tgcctacgga 17820 aagcggcata aggacatgct ggcgttgccg ctggacgagg gcaacccaac acctagccta 17880 aagcccgtaa cactgcagca ggtgctgccc gcgcttgcac cgtccgaaga aaagcgcggc 17940 ctaaagcgcg agtctggtga cttggcaccc accgtgcagc tgatggtacc caagcgccag 18000 cgactggaag atgtcttgga aaaaatgacc gtggaacctg ggctggagcc cgaggtccgc 18060 gtgcggccaa tcaagcaggt ggcgccggga ctgggcgtgc agaccgtgga cgttcagata 18120 cccactacca gtagcaccag tattgccacc gccacagagg gcatggagac acaaacgtcc 18180 ccggttgcct cagcggtggc ggatgccgcg gtgcaggcgg tcgctgcggc cgcgtccaag 18240 acctctacgg aggtgcaaac ggacccgtgg atgtttcgcg tttcagcccc ccggcgcccg 18300 cgccgttcga ggaagtacgg cgccgccagc gcgctactgc ccgaatatgc cctacatcct 18360 tccattgcgc ctacccccgg ctatcgtggc tacacctacc gccccagaag acgagcaact 18420 acccgacgcc gaaccaccac tggaacccgc cgccgccgtc gccgtcgcca gcccgtgctg 18480 gccccgattt ccgtgcgcag ggtggctcgc gaaggaggca ggaccctggt gctgccaaca 18540 gcgcgctacc accccagcat cgtttaaaag ccggtctttg tggttcttgc agatatggcc 18600 ctcacctgcc gcctccgttt cccggtgccg ggattccgag gaagaatgca ccgtaggagg 18660 ggcatggccg gccacggcct gacgggcggc atgcgtcgtg cgcaccaccg gcggcggcgc 18720 gcgtcgcacc gtcgcatgcg cggcggtatc ctgcccctcc ttattccact gatcgccgcg 18780 gcgattggcg ccgtgcccgg aattgcatcc gtggccttgc aggcgcagag acactgatta 18840 aaaacaagtt gcatgtggaa aaatcaaaat aaaaagtctg gactctcacg ctcgcttggt 18900 cctgtaacta ttttgtagaa tggaagacat caactttgcg tctctggccc cgcgacacgg 18960 ctcgcgcccg ttcatgggaa actggcaaga tatcggcacc agcaatatga gcggtggcgc 19020 cttcagctgg ggctcgctgt ggagcggcat taaaaatttc ggttccaccg ttaagaacta 19080 tggcagcaag gcctggaaca gcagcacagg ccagatgctg agggataagt tgaaagagca 19140 aaatttccaa caaaaggtgg tagatggcct ggcctctggc attagcgggg tggtggacct 19200 ggccaaccag gcagtgcaaa ataagattaa cagtaagctt gatccccgcc ctcccgtaga 19260 ggagcctcca ccggccgtgg agacagtgtc tccagagggg cgtggcgaaa agcgtccgcg 19320 ccccgacagg gaagaaactc tggtgacgca aatagacgag cctccctcgt acgaggaggc 19380 actaaagcaa ggcctgccca ccacccgtcc catcgcgccc atggctaccg gagtgctggg 19440 ccagcacaca cccgtaacgc tggacctgcc tccccccgcc gacacccagc agaaacctgt 19500 gctgccaggc ccgaccgccg ttgttgtaac ccgtcctagc cgcgcgtccc tgcgccgcgc 19560 cgccagcggt ccgcgatcgt tgcggcccgt agccagtggc aactggcaaa gcacactgaa 19620 cagcatcgtg ggtctggggg tgcaatccct gaagcgccga cgatgcttct gaatagctaa 19680 cgtgtcgtat gtgtgtcatg tatgcgtcca tgtcgccgcc agaggagctg ctgagccgcc 19740 gcgcgcccgc tttccaagat ggctacccct tcgatgatgc cgcagtggtc ttacatgcac 19800 atctcgggcc aggacgcctc ggagtacctg agccccgggc tggtgcagtt tgcccgcgcc 19860 accgagacgt acttcagcct gaataacaag tttagaaacc ccacggtggc gcctacgcac 19920 gacgtgacca cagaccggtc ccagcgtttg acgctgcggt tcatccctgt ggaccgtgag 19980 gatactgcgt actcgtacaa ggcgcggttc accctagctg tgggtgataa ccgtgtgctg 20040 gacatggctt ccacgtactt tgacatccgc ggcgtgctgg acaggggccc tacttttaag 20100 ccctactctg gcactgccta caacgccctg gctcccaagg gtgccccaaa tccttgcgaa 20160 tgggatgaag ctgctactgc tcttgaaata aacctagaag aagaggacga tgacaacgaa 20220 gacgaagtag acgagcaagc tgagcagcaa aaaactcacg tatttgggca ggcgccttat 20280 tctggtataa atattacaaa ggagggtatt caaataggtg tcgaaggtca aacacctaaa 20340 tatgccgata aaacatttca acctgaacct caaataggag aatctcagtg gtacgaaact 20400 gaaattaatc atgcagctgg gagagtcctt aaaaagacta ccccaatgaa accatgttac 20460 ggttcatatg caaaacccac aaatgaaaat ggagggcaag gcattcttgt aaagcaacaa 20520 aatggaaagc tagaaagtca agtggaaatg caatttttct caactactga ggcgaccgca 20580 ggcaatggtg ataacttgac tcctaaagtg gtattgtaca gtgaagatgt agatatagaa 20640 accccagaca ctcatatttc ttacatgccc actattaagg aaggtaactc acgagaacta 20700 atgggccaac aatctatgcc caacaggcct aattacattg cttttaggga caattttatt 20760 ggtctaatgt attacaacag cacgggtaat atgggtgttc tggcgggcca agcatcgcag 20820 ttgaatgctg ttgtagattt gcaagacaga aacacagagc tttcatacca gcttttgctt 20880 gattccattg gtgatagaac caggtacttt tctatgtgga atcaggctgt tgacagctat 20940 gatccagatg ttagaattat tgaaaatcat ggaactgaag atgaacttcc aaattactgc 21000 tttccactgg gaggtgtgat taatacagag actcttacca aggtaaaacc taaaacaggt 21060 caggaaaatg gatgggaaaa agatgctaca gaattttcag ataaaaatga aataagagtt 21120 ggaaataatt ttgccatgga aatcaatcta aatgccaacc tgtggagaaa tttcctgtac 21180 tccaacatag cgctgtattt gcccgacaag ctaaagtaca gtccttccaa cgtaaaaatt 21240 tctgataacc caaacaccta cgactacatg aacaagcgag tggtggctcc cgggttagtg 21300 gactgctaca ttaaccttgg agcacgctgg tcccttgact atatggacaa cgtcaaccca 21360 tttaaccacc accgcaatgc tggcctgcgc taccgctcaa tgttgctggg caatggtcgc 21420 tatgtgccct tccacatcca ggtgcctcag aagttctttg ccattaaaaa cctccttctc 21480 ctgccgggct catacaccta cgagtggaac ttcaggaagg atgttaacat ggttctgcag 21540 agctccctag gaaatgacct aagggttgac ggagccagca ttaagtttga tagcatttgc 21600 ctttacgcca ccttcttccc catggcccac aacaccgcct ccacgcttga ggccatgctt 21660 agaaacgaca ccaacgacca gtcctttaac gactatctct ccgccgccaa catgctctac 21720 cctatacccg ccaacgctac caacgtgccc atatccatcc cctcccgcaa ctgggcggct 21780 ttccgcggct gggccttcac gcgccttaag actaaggaaa ccccatcact gggctcgggc 21840 tacgaccctt attacaccta ctctggctct ataccctacc tagatggaac cttttacctc 21900 aaccacacct ttaagaaggt ggccattacc tttgactctt ctgtcagctg gcctggcaat 21960 gaccgcctgc ttacccccaa cgagtttgaa attaagcgct cagttgacgg ggagggttac 22020 aacgttgccc agtgtaacat gaccaaagac tggttcctgg tacaaatgct agctaactac 22080 aacattggct accagggctt ctatatccca gagagctaca aggaccgcat gtactccttc 22140 tttagaaact tccagcccat gagccgtcag gtggtggatg atactaaata caaggactac 22200 caacaggtgg gcatcctaca ccaacacaac aactctggat ttgttggcta ccttgccccc 22260 accatgcgcg aaggacaggc ctaccctgct aacttcccct atccgcttat aggcaagacc 22320 gcagttgaca gcattaccca gaaaaagttt ctttgcgatc gcaccctttg gcgcatccca 22380 ttctccagta actttatgtc catgggcgca ctcacagacc tgggccaaaa ccttctctac 22440 gccaactccg cccacgcgct agacatgact tttgaggtgg atcccatgga cgagcccacc 22500 cttctttatg ttttgtttga agtctttgac gtggtccgtg tgcaccggcc gcaccgcggc 22560 gtcatcgaaa ccgtgtacct gcgcacgccc ttctcggccg gcaacgccac aacataaaga 22620 agcaagcaac atcaacaaca gctgccgcca tgggctccag tgagcaggaa ctgaaagcca 22680 ttgtcaaaga tcttggttgt gggccatatt ttttgggcac ctatgacaag cgctttccag 22740 gctttgtttc tccacacaag ctcgcctgcg ccatagtcaa tacggccggt cgcgagactg 22800 ggggcgtaca ctggatggcc tttgcctgga acccgcactc aaaaacatgc tacctctttg 22860 agccctttgg cttttctgac cagcgactca agcaggttta ccagtttgag tacgagtcac 22920 tcctgcgccg tagcgccatt gcttcttccc ccgaccgctg tataacgctg gaaaagtcca 22980 cccaaagcgt acaggggccc aactcggccg cctgtggact attctgctgc atgtttctcc 23040 acgcctttgc caactggccc caaactccca tggatcacaa ccccaccatg aaccttatta 23100 ccggggtacc caactccatg ctcaacagtc cccaggtaca gcccaccctg cgtcgcaacc 23160 aggaacagct ctacagcttc ctggagcgcc actcgcccta cttccgcagc cacagtgcgc 23220 agattaggag cgccacttct ttttgtcact tgaaaaacat gtaaaaataa tgtactagag 23280 acactttcaa taaaggcaaa tgcttttatt tgtacactct cgggtgatta tttaccccca 23340 cccttgccgt ctgcgccgtt taaaaatcaa aggggttctg ccgcgcatcg ctatgcgcca 23400 ctggcaggga cacgttgcga tactggtgtt tagtgctcca cttaaactca ggcacaacca 23460 tccgcggcag ctcggtgaag ttttcactcc acaggctgcg caccatcacc aacgcgttta 23520 gcaggtcggg cgccgatatc ttgaagtcgc agttggggcc tccgccctgc gcgcgcgagt 23580 tgcgatacac agggttgcag cactggaaca ctatcagcgc cgggtggtgc acgctggcca 23640 gcacgctctt gtcggagatc agatccgcgt ccaggtcctc cgcgttgctc agggcgaacg 23700 gagtcaactt tggtagctgc cttcccaaaa agggcgcgtg cccaggcttt gagttgcact 23760 cgcaccgtag tggcatcaaa aggtgaccgt gcccggtctg ggcgttagga tacagcgcct 23820 gcataaaagc cttgatctgc ttaaaagcca cctgagcctt tgcgccttca gagaagaaca 23880 tgccgcaaga cttgccggaa aactgattgg ccggacaggc cgcgtcgtgc acgcagcacc 23940 ttgcgtcggt gttggagatc tgcaccacat ttcggcccca ccggttcttc acgatcttgg 24000 ccttgctaga ctgctccttc agcgcgcgct gcccgttttc gctcgtcaca tccatttcaa 24060 tcacgtgctc cttatttatc ataatgcttc cgtgtagaca cttaagctcg ccttcgatct 24120 cagcgcagcg gtgcagccac aacgcgcagc ccgtgggctc gtgatgcttg taggtcacct 24180 ctgcaaacga ctgcaggtac gcctgcagga atcgccccat catcgtcaca aaggtcttgt 24240 tgctggtgaa ggtcagctgc aacccgcggt gctcctcgtt cagccaggtc ttgcatacgg 24300 ccgccagagc ttccacttgg tcaggcagta gtttgaagtt cgcctttaga tcgttatcca 24360 cgtggtactt gtccatcagc gcgcgcgcag cctccatgcc cttctcccac gcagacacga 24420 tcggcacact cagcgggttc atcaccgtaa tttcactttc cgcttcgctg ggctcttcct 24480 cttcctcttg cgtccgcata ccacgcgcca ctgggtcgtc ttcattcagc cgccgcactg 24540 tgcgcttacc tcctttgcca tgcttgatta gcaccggtgg gttgctgaaa cccaccattt 24600 gtagcgccac atcttctctt tcttcctcgc tgtccacgat tacctctggt gatggcgggc 24660 gctcgggctt gggagaaggg cgcttctttt tcttcttggg cgcaatggcc aaatccgccg 24720 ccgaggtcga tggccgcggg ctgggtgtgc gcggcaccag cgcgtcttgt gatgagtctt 24780 cctcgtcctc ggactcgata cgccgcctca tccgcttttt tgggggcgcc cggggaggcg 24840 gcggcgacgg ggacggggac gacacgtcct ccatggttgg gggacgtcgc gccgcaccgc 24900 gtccgcgctc gggggtggtt tcgcgctgct cctcttcccg actggccatt tccttctcct 24960 ataggcagaa aaagatcatg gagtcagtcg agaagaagga cagcctaacc gccccctctg 25020 agttcgccac caccgcctcc accgatgccg ccaacgcgcc taccaccttc cccgtcgagg 25080 cacccccgct tgaggaggag gaagtgatta tcgagcagga cccaggtttt gtaagcgaag 25140 acgacgagga ccgctcagta ccaacagagg ataaaaagca agaccaggac aacgcagagg 25200 caaacgagga acaagtcggg cggggggacg aaaggcatgg cgactaccta gatgtgggag 25260 acgacgtgct gttgaagcat ctgcagcgcc agtgcgccat tatctgcgac gcgttgcaag 25320 agcgcagcga tgtgcccctc gccatagcgg atgtcagcct tgcctacgaa cgccacctat 25380 tctcaccgcg cgtacccccc aaacgccaag aaaacggcac atgcgagccc aacccgcgcc 25440 tcaacttcta ccccgtattt gccgtgccag aggtgcttgc cacctatcac atctttttcc 25500 aaaactgcaa gataccccta tcctgccgtg ccaaccgcag ccgagcggac aagcagctgg 25560 ccttgcggca gggcgctgtc atacctgata tcgcctcgct caacgaagtg ccaaaaatct 25620 ttgagggtct tggacgcgac gagaagcgcg cggcaaacgc tctgcaacag gaaaacagcg 25680 aaaatgaaag tcactctgga gtgttggtgg aactcgaggg tgacaacgcg cgcctagccg 25740 tactaaaacg cagcatcgag gtcacccact ttgcctaccc ggcacttaac ctacccccca 25800 aggtcatgag cacagtcatg agtgagctga tcgtgcgccg tgcgcagccc ctggagaggg 25860 atgcaaattt gcaagaacaa acagaggagg gcctacccgc agttggcgac gagcagctag 25920 cgcgctggct tcaaacgcgc gagcctgccg acttggagga gcgacgcaaa ctaatgatgg 25980 ccgcagtgct cgttaccgtg gagcttgagt gcatgcagcg gttctttgct gacccggaga 26040 tgcagcgcaa gctagaggaa acattgcact acacctttcg acagggctac gtacgccagg 26100 cctgcaagat ctccaacgtg gagctctgca acctggtctc ctaccttgga attttgcacg 26160 aaaaccgcct tgggcaaaac gtgcttcatt ccacgctcaa gggcgaggcg cgccgcgact 26220 acgtccgcga ctgcgtttac ttatttctat gctacacctg gcagacggcc atgggcgttt 26280 ggcagcagtg cttggaggag tgcaacctca aggagctgca gaaactgcta aagcaaaact 26340 tgaaggacct atggacggcc ttcaacgagc gctccgtggc cgcgcacctg gcggacatca 26400 ttttccccga acgcctgctt aaaaccctgc aacagggtct gccagacttc accagtcaaa 26460 gcatgttgca gaactttagg aactttatcc tagagcgctc aggaatcttg cccgccacct 26520 gctgtgcact tcctagcgac tttgtgccca ttaagtaccg cgaatgccct ccgccgcttt 26580 ggggccactg ctaccttctg cagctagcca actaccttgc ctaccactct gacataatgg 26640 aagacgtgag cggtgacggt ctactggagt gtcactgtcg ctgcaaccta tgcaccccgc 26700 accgctccct ggtttgcaat tcgcagctgc ttaacgaaag tcaaattatc ggtacctttg 26760 agctgcaggg tccctcgcct gacgaaaagt ccgcggctcc ggggttgaaa ctcactccgg 26820 ggctgtggac gtcggcttac cttcgcaaat ttgtacctga ggactaccac gcccacgaga 26880 ttaggttcta cgaagaccaa tcccgcccgc caaatgcgga gcttaccgcc tgcgtcatta 26940 cccagggcca cattcttggc caattgcaag ccatcaacaa agcccgccaa gagtttctgc 27000 tacgaaaggg acggggggtt tacttggacc cccagtccgg cgaggagctc aacccaatcc 27060 ccccgccgcc gcagccctat cagcagcagc cgcgggccct tgcttcccag gatggcaccc 27120 aaaaagaagc tgcagctgcc gccgccaccc acggacgagg aggaatactg ggacagtcag 27180 gcagaggagg ttttggacga ggaggaggag gacatgatgg aagactggga gagcctagac 27240 gaggaagctt ccgaggtcga agaggtgtca gacgaaacac cgtcaccctc ggtcgcattc 27300 ccctcgccgg cgccccagaa atcggcaacc ggttccagca tggctacaac ctccgctcct 27360 caggcgccgc cggcactgcc cgttcgccga cccaaccgta gatgggacac cactggaacc 27420 agggccggta agtccaagca gccgccgccg ttagcccaag agcaacaaca gcgccaaggc 27480 taccgctcat ggcgcgggca caagaacgcc atagttgctt gcttgcaaga ctgtgggggc 27540 aacatctcct tcgcccgccg ctttcttctc taccatcacg gcgtggcctt cccccgtaac 27600 atcctgcatt actaccgtca tctctacagc ccatactgca ccggcggcag cggcagcggc 27660 agcaacagca gcggccacac agaagcaaag gcgaccggat agcaagactc tgacaaagcc 27720 caagaaatcc acagcggcgg cagcagcagg aggaggagcg ctgcgtctgg cgcccaacga 27780 acccgtatcg acccgcgagc ttagaaacag gatttttccc actctgtatg ctatatttca 27840 acagagcagg ggccaagaac aagagctgaa aataaaaaac aggtctctgc gatccctcac 27900 ccgcagctgc ctgtatcaca aaagcgaaga tcagcttcgg cgcacgctgg aagacgcgga 27960 ggctctcttc agtaaatact gcgcgctgac tcttaaggac tagtttcgcg ccctttctca 28020 aatttaagcg cgaaaactac gtcatctcca gcggccacac ccggcgccag cacctgtcgt 28080 cagcgccatt tcaactttgt atacaaaagt tgtgatgagc aaggaaattc ccacgcccta 28140 catgtggagt taccagccac aaatgggact tgcggctgga gctgcccaag actactcaac 28200 ccgaataaac tacatgagcg cgggacccca catgatatcc cgggtcaacg gaatacgcgc 28260 ccaccgaaac cgaattctcc tggaacaggc ggctattacc accacacctc gtaataacct 28320 taatccccgt agttggcccg ctgccctggt gtaccaggaa agtcccgctc ccaccactgt 28380 ggtacttccc agagacgccc aggccgaagt tcagatgact aactcagggg cgcagcttgc 28440 gggcggcttt cgtcacaggg tgcggtcgcc cgggcagggt ataactcacc tgacaatcag 28500 agggcgaggt attcagctca acgacgagtc ggtgagctcc tcgcttggtc tccgtccgga 28560 cgggacattt cagatcggcg gcgccggccg ctcttcattc acgcctcgtc aggcaatcct 28620 aactctgcag acctcgtcct ctgagccgcg ctctggaggc attggaactc tgcaatttat 28680 tgaggagttt gtgccatcgg tctactttaa ccccttctcg ggacctcccg gccactatcc 28740 ggatcaattt attcctaact ttgacgcggt aaaggactcg gcggacggct acgactgaat 28800 gttaagtgga gaggcagagc aactgcgcct gaaacacctg gtccactgtc gccgccacaa 28860 gtgctttgcc cgcgactccg gtgagttttg ctactttgaa ttgcccgagg atcatatcga 28920 gggcccggcg cacggcgtcc ggcttaccgc ccagggagag cttgcccgta gcctgattcg 28980 ggagtttacc cagcgccccc tgctagttga gcgggacagg ggaccctgtg ttctcactgt 29040 gatttgcaac tgtcctaacc ctggattaca tcaagatctt tgttgccatc tctgtgctga 29100 gtataataaa tacagaaatt aaaatatact ggggctccta tcgccatcct gtaaacgcca 29160 ccgtcttcac ccgcccaagc aaaccaaggc gaaccttacc tggtactttt aacatctctc 29220 cctctgtgat ttacaacagt ttcaacccag acggagtgag tctacgagag aacctctccg 29280 agctcagcta ctccatcaga aaaaacacca ccctccttac ctgccgggaa cgtacgagtg 29340 cgtcaccggc cgctgcacca cacctaccgc ctgaccgtaa accagacttt ttccggacag 29400 acctcaataa ctctgtttac cagaacagga ggtgagctta gaaaaccctt agggtattag 29460 gccaaaggcg cagctactgt ggggtttatg aacaattcaa gcaactctac gggctattct 29520 aattcaggtt tctctagaat cggggttggg gttattctct gtcttgtgat tctctttatt 29580 cttatactaa cgcttctctg cctaaggctc gccgcctgct gtgtgcacat ttgcatttat 29640 tgtcagcttt ttaaacgctg gggtcgccac ccaagatgat taggtacata atcctaggtt 29700 tactcaccct tgcgtcagcc cacggtacca cccaaaaggt ggattttaag gagccagcct 29760 gtaatgttac attcgcagct gaagctaatg agtgcaccac tcttataaaa tgcaccacag 29820 aacatgaaaa gctgcttatt cgccacaaaa acaaaattgg caagtatgct gtttatgcta 29880 tttggcagcc aggtgacact acagagtata atgttacagt tttccagggt aaaagtcata 29940 aaacttttat gtatactttt ccattttatg aaatgtgcga cattaccatg tacatgagca 30000 aacagtataa gttgtggccc ccacaaaatt gtgtggaaaa cactggcact ttctgctgca 30060 ctgctatgct aattacagtg ctcgctttgg tctgtaccct actctatatt aaatacaaaa 30120 gcagacgcag ctttattgag gaaaagaaaa tgccttaatt tactaagtta caaagctaat 30180 gtcaccacta actgctttac tcgctgcttg caaaacaaat tcaaaaagtt agcattataa 30240 ttagaatagg atttaaaccc cccggtcatt tcctgctcaa taccattccc ctgaacaatt 30300 gactctatgt gggatatgct ccagcgctac aaccttgaag tcaggcttcc tggatgtcag 30360 catctgactt tggccagcac ctgtcccgcg gatttgttcc agtccaacta cagcgaccca 30420 ccctaacaga gatgaccaac acaaccaacg cggccgccgc taccggactt acatctacca 30480 caaatacacc ccaagtttct gcctttgtca ataactggga taacttgggc atgtggtggt 30540 tctccatagc gcttatgttt gtatgcctta ttattatgtg gctcatctgc tgcctaaagc 30600 gcaaacgcgc ccgaccaccc atctatagtc ccatcattgt gctacaccca aacaatgatg 30660 gaatccatag attggacgga ctgaaacaca tgttcttttc tcttacagta tgattaaatg 30720 agacatgatt cctcgagttt ttatattact gacccttgtt gcgctttttt gtgcgtgctc 30780 cacattggct gcggtttctc acatcgaagt agactgcatt ccagccttca cagtctattt 30840 gctttacgga tttgtcaccc tcacgctcat ctgcagcctc atcactgtgg tcatcgcctt 30900 tatccagtgc attgactggg tctgtgtgcg ctttgcatat ctcagacacc atccccagta 30960 cagggacagg actatagctg agcttcttag aattctttaa ttatgaaatt tactgtgact 31020 tttctgctga ttatttgcac cctatctgcg ttttgttccc cgacctccaa gcctcaaaga 31080 catatatcat gcagattcac tcgtatatgg aatattccaa gttgctacaa tgaaaaaagc 31140 gatctttccg aagcctggtt atatgcaatc atctctgtta tggtgttctg cagtaccatc 31200 ttagccctag ctatatatcc ctaccttgac attggctgga acgcaataga tgccatgaac 31260 cacccaactt tccccgcgcc cgctatgctt ccactgcaac aagttgttgc cggcggcttt 31320 gtcccagcca atcagcctcg cccaccttct cccaccccca ctgaaatcag ctactttaat 31380 ctaacaggag gagatgactg acaccctaga tctagaaatg gacggaatta ttacagagca 31440 gcgcctgcta gaaagacgca gggcagcggc cgagcaacag cgcatgaatc aagagctcca 31500 agacatggtt aacttgcacc agtgcaaaag gggtatcttt tgtctggtaa agcaggccaa 31560 agtcacctac gacagtaata ccaccggaca ccgccttagc tacaagttgc caaccaagcg 31620 tcagaaattg gtggtcatgg tgggagaaaa gcccattacc ataactcagc actcggtaga 31680 aaccgaaggc tgcattcact caccttgtca aggacctgag gatctctgca cccttattaa 31740 gaccctgtgc ggtctcaaag atcttattcc ctttaactaa taaaaaaaaa taataaagca 31800 tcacttactt aaaatcagtt agcaaatttc tgtccagttt attcagcagc acctccttgc 31860 cctcctccca gctctggtat tgcagcttcc tcctggctgc aaactttctc cacaatctaa 31920 atggaatgtc agtttcctcc tgttcctgtc catccgcacc cactatcttc atgttgttgc 31980 agatgaagcg cgcaagaccg tctgaagata ccttcaaccc cgtgtatcca tatgacacgg 32040 aaaccggtcc tccaactgtg ccttttctta ctcctccctt tgtatccccc aatgggtttc 32100 aagagagtcc ccctggggta ctctctttgc gcctatccga acctctagtt acctccaatg 32160 gcatgcttgc gctcaaaatg ggcaacggcc tctctctgga cgaggccggc aaccttacct 32220 cccaaaatgt aaccactgtg agcccacctc tcaaaaaaac caagtcaaac ataaacctgg 32280 aaatatctgc acccctcaca gttacctcag aagccctaac tgtggctgcc gccgcacctc 32340 taatggtcgc gggcaacaca ctcaccatgc aatcacaggc cccgctaacc gtgcacgact 32400 ccaaacttag cattgccacc caaggacccc tcacagtgtc agaaggaaag ctagccctgc 32460 aaacatcagg ccccctcacc accaccgata gcagtaccct tactatcact gcctcacccc 32520 ctctaactac tgccactggt agcttgggca ttgacttgaa agagcccatt tatacacaaa 32580 atggaaaact aggactaaag tacggggctc ctttgcatgt aacagacgac ctaaacactt 32640 tgaccgtagc aactggtcca ggtgtgacta ttaataatac ttccttgcaa actaaagtta 32700 ctggagcctt gggttttgat tcacaaggca atatgcaact taatgtagca ggaggactaa 32760 ggattgattc tcaaaacaga cgccttatac ttgatgttag ttatccgttt gatgctcaaa 32820 accaactaaa tctaagacta ggacagggcc ctctttttat aaactcagcc cacaacttgg 32880 atattaacta caacaaaggc ctttacttgt ttacagcttc aaacaattcc aaaaagcttg 32940 aggttaacct aagcactgcc aaggggttga tgtttgacgc tacagccata gccattaatg 33000 caggagatgg gcttgaattt ggttcaccta atgcaccaaa cacaaatccc ctcaaaacaa 33060 aaattggcca tggcctagaa tttgattcaa acaaggctat ggttcctaaa ctaggaactg 33120 gccttagttt tgacagcaca ggtgccatta cagtaggaaa caaaaataat gataagctaa 33180 ctttgtggac cacaccagct ccatctccta actgtagact aaatgcagag aaagatgcta 33240 aactcacttt ggtcttaaca aaatgtggca gtcaaatact tgctacagtt tcagttttgg 33300 ctgttaaagg cagtttggct ccaatatctg gaacagttca aagtgctcat cttattataa 33360 gatttgacga aaatggagtg ctactaaaca attccttcct ggacccagaa tattggaact 33420 ttagaaatgg agatcttact gaaggcacag cctatacaaa cgctgttgga tttatgccta 33480 acctatcagc ttatccaaaa tctcacggta aaactgccaa aagtaacatt gtcagtcaag 33540 tttacttaaa cggagacaaa actaaacctg taacactaac cattacacta aacggtacac 33600 aggaaacagg agacacaact ccaagtgcat actctatgtc attttcatgg gactggtctg 33660 gccacaacta cattaatgaa atatttgcca catcctctta cactttttca tacattgccc 33720 aagaataaag aatcgtttgt gttatgtttc aacgtgttta tttttcaatt gcagaaaatt 33780 tcaagtcatt tttcattcag tagtatagcc ccaccaccac atagcttata cagatcaccg 33840 tacctcaact ttgtataata aagttgtaat caaactcaca gaaccctagt attcaacctg 33900 ccacctccct cccaacacac agagtacaca gtcctttctc cccggctggc cttaaaaagc 33960 atcatatcat gggtaacaga catattctta ggtgttatat tccacacggt ttcctgtcga 34020 gccaaacgct catcagtgat attaataaac tccccgggca gctcacttaa gttcatgtcg 34080 ctgtccagct gctgagccac aggctgctgt ccaacttgcg gttgcttaac gggcggcgaa 34140 ggagaagtcc acgcctacat gggggtagag tcataatcgt gcatcaggat agggcggtgg 34200 tgctgcagca gcgcgcgaat aaactgctgc cgccgccgct ccgtcctgca ggaatacaac 34260 atggcagtgg tctcctcagc gatgattcgc accgcccgca gcataaggcg ccttgtcctc 34320 cgggcacagc agcgcaccct gatctcactt aaatcagcac agtaactgca gcacagcacc 34380 acaatattgt tcaaaatccc acagtgcaag gcgctgtatc caaagctcat ggcggggacc 34440 acagaaccca cgtggccatc ataccacaag cgcaggtaga ttaagtggcg acccctcata 34500 aacacgctgg acataaacat tacctctttt ggcatgttgt aattcaccac ctcccggtac 34560 catataaacc tctgattaaa catggcgcca tccaccacca tcctaaacca gctggccaaa 34620 acctgcccgc cggctataca ctgcagggaa ccgggactgg aacaatgaca gtggagagcc 34680 caggactcgt aaccatggat catcatgctc gtcatgatat caatgttggc acaacacagg 34740 cacacgtgca tacacttcct caggattaca agctcctccc gcgttagaac catatcccag 34800 ggaacaaccc attcctgaat cagcgtaaat cccacactgc agggaagacc tcgcacgtaa 34860 ctcacgttgt gcattgtcaa agtgttacat tcgggcagca gcggatgatc ctccagtatg 34920 gtagcgcggg tttctgtctc aaaaggaggt agacgatccc tactgtacgg agtgcgccga 34980 gacaaccgag atcgtgttgg tcgtagtgtc atgccaaatg gaacgccgga cgtagtcata 35040 tttcctgaag caaaaccagg tgcgggcgtg acaaacagat ctgcgtctcc ggtctcgccg 35100 cttagatcgc tctgtgtagt agttgtagta tatccactct ctcaaagcat ccaggcgccc 35160 cctggcttcg ggttctatgt aaactccttc atgcgccgct gccctgataa catccaccac 35220 cgcagaataa gccacaccca gccaacctac acattcgttc tgcgagtcac acacgggagg 35280 agcgggaaga gctggaagaa ccatgttttt ttttttattc caaaagatta tccaaaacct 35340 caaaatgaag atctattaag tgaacgcgct cccctccggt ggcgtggtca aactctacag 35400 ccaaagaaca gataatggca tttgtaagat gttgcacaat ggcttccaaa aggcaaacgg 35460 ccctcacgtc caagtggacg taaaggctaa acccttcagg gtgaatctcc tctataaaca 35520 ttccagcacc ttcaaccatg cccaaataat tctcatctcg ccaccttctc aatatatctc 35580 taagcaaatc ccgaatatta agtccggcca ttgtaaaaat ctgctccaga gcgccctcca 35640 ccttcagcct caagcagcga atcatgattg caaaaattca ggttcctcac agacctgtat 35700 aagattcaaa agcggaacat taacaaaaat accgcgatcc cgtaggtccc ttcgcagggc 35760 cagctgaaca taatcgtgca ggtctgcacg gaccagcgcg gccacttccc cgccaggaac 35820 catgacaaaa gaacccacac tgattatgac acgcatactc ggagctatgc taaccagcgt 35880 agccccgatg taagcttgtt gcatgggcgg cgatataaaa tgcaaggtgc tgctcaaaaa 35940 atcaggcaaa gcctcgcgca aaaaagaaag cacatcgtag tcatgctcat gcagataaag 36000 gcaggtaagc tccggaacca ccacagaaaa agacaccatt tttctctcaa acatgtctgc 36060 gggtttctgc ataaacacaa aataaaataa caaaaaaaca tttaaacatt agaagcctgt 36120 cttacaacag gaaaaacaac ccttataagc ataagacgga ctacggccat gccggcgtga 36180 ccgtaaaaaa actggtcacc gtgattaaaa agcaccaccg acagctcctc ggtcatgtcc 36240 ggagtcataa tgtaagactc ggtaaacaca tcaggttgat tcacatcggt cagtgctaaa 36300 aagcgaccga aatagcccgg gggaatacat acccgcaggc gtagagacaa cattacagcc 36360 cccataggag gtataacaaa attaatagga gagaaaaaca cataaacacc tgaaaaaccc 36420 tcctgcctag gcaaaatagc accctcccgc tccagaacaa catacagcgc ttccacagcg 36480 gcagccataa cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa acaccactcg 36540 acacggcacc agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat 36600 ataggactaa aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg 36660 cgaacctacg cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc 36720 gttttcccac gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag 36780 ttactccgcc ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa 36840 actccacccc ctcattatca tattggcttc aatccaaaat aaggtatatt attgatgatg 36900 <210> 28 <211> 36913 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO200) <400> 28 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattaaac cgtattaccg ccatgcattt aatggagtgc 480 ctcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa 540 gttgggggga ggggtcggca attgaaccgg tgcctagaga aggtggcgcg gggtaaactg 600 ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat 660 aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacaggt 720 aagtgccgtg tgtggttccc gcgggcctgg cctctttacg ggttatggcc cttgcgtgcc 780 ttgaattact tccacctggc tgcagtacgt gattcttgat cccgagcttc gggttggaag 840 tgggtgggag agttcgaggc cttgcgctta aggagcccct tcgcctcgtg cttgagttga 900 ggcctggcct gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct 960 cgctgctttc gataagtctc tagccattta aaatttttga tgacctgctg cgacgctttt 1020 tttctggcaa gatagtcttg taaatgcggg ccaagatctg cacactggta tttcggtttt 1080 tggggccgcg ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg 1140 cctgcgagcg cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct 1200 ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc 1260 ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag ggagctcaaa 1320 atggaggacg cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc 1380 ctttccgtcc tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca 1440 cctcgattag ttctcgagct tttggagtac gtcgtcttta ggttgggggg aggggtttta 1500 tgcgatggag tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt 1560 gatgtaattc tccttggaat ttgccctttt tgagtttgga tcttggttca ttctcaagcc 1620 tcagacagtg gttcaaagtt tttttcttcc atttcaggtg tcgtgacgct agcgctaccg 1680 gactcagatc tcgagctcaa gcttcgaatt ctgcagtcga cggtaccgga tccatggaag 1740 acgccaaaaa cataaagaaa ggcccggcgc cattctatcc gctggaagat ggaaccgctg 1800 gagagcaact gcataaggct atgaagagat acgccctggt tcctggaaca attgctttta 1860 cagatgcaca tatcgaggtg gacatcactt acgctgagta cttcgaaatg tccgttcggt 1920 tggcagaagc tatgaaacga tatgggctga atacaaatca cagaatcgtc gtatgcagtg 1980 aaaactctct tcaattcttt atgccggtgt tgggcgcgtt atttatcgga gttgcagttg 2040 cgcccgcgaa cgacatttat aatgaacgtg aattgctcaa cagtatgggc atttcgcagc 2100 ctaccgtggt gttcgtttcc aaaaaggggt tgcaaaaaat tttgaacgtg caaaaaaagc 2160 tcccaatcat ccaaaaaatt attatcatgg attctaaaac ggattaccag ggatttcagt 2220 cgatgtacac gttcgtcaca tctcatctac ctcccggttt taatgaatac gattttgtgc 2280 cagagtcctt cgatagggac aagacaattg cactgatcat gaactcctct ggatctactg 2340 gtctgcctaa aggtgtcgct ctgcctcata gaactgcctg cgtgagattc tcgcatgcca 2400 gagatcctat ttttggcaat caaatcattc cggatactgc gattttaagt gttgttccat 2460 tccatcacgg ttttggaatg tttactacac tcggatattt gatatgtgga tttcgagtcg 2520 tcttaatgta tagatttgaa gaagagctgt ttctgaggag ccttcaggat tacaagattc 2580 aaagtgcgct gctggtgcca accctattct ccttcttcgc caaaagcact ctgattgaca 2640 aatacgattt atctaattta cacgaaattg cttctggtgg cgctcccctc tctaaggaag 2700 tcggggaagc ggttgccaag aggttccatc tgccaggtat caggcaagga tatgggctca 2760 ctgagactac atcagctatt ctgattacac ccgaggggga tgataaaccg ggcgcggtcg 2820 gtaaagttgt tccatttttt gaagcgaagg ttgtggatct ggataccggg aaaacgctgg 2880 gcgttaatca aagaggcgaa ctgtgtgtga gaggtcctat gattatgtcc ggttatgtaa 2940 acaatccgga agcgaccaac gccttgattg acaaggatgg atggctacat tctggagaca 3000 tagcttactg ggacgaagac gaacacttct tcatcgttga ccgcctgaag tctctgatta 3060 agtacaaagg ctatcaggtg gctcccgctg aattggaatc catcttgctc caacacccca 3120 acatcttcga cgcaggtgtc gcaggtcttc ccgacgatga cgccggtgaa cttcccgccg 3180 ccgttgttgt tttggagcac ggaaagacga tgacggaaaa agagatcgtg gattacgtcg 3240 ccagtcaagt aacaaccgcg aaaaagttgc gcggaggagt tgtgtttgtg gacgaagtac 3300 cgaaaggtct taccggaaaa ctcgacgcaa gaaaaatcag agagatcctc ataaaggcca 3360 agaagggcgg aaagatcgcc gtggcagccg cagccaccat ggtgagcaag ggcgaggagc 3420 tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt 3480 tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca 3540 tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg 3600 gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg 3660 ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca 3720 agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg 3780 gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca 3840 gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga 3900 tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc 3960 ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc 4020 tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg 4080 ccgggatcac tctcggcatg gacgagctgt acaagtaaag cgactctaga tcataatcag 4140 ccatacccaa acaccattgt cacactccaa tcgattcaaa caccattgtc acactccaac 4200 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4260 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4320 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4380 tttgtccaaa ctcatcaatg taagtttaaa cggcgcgcct gaaatgtgtg ggcgtggctt 4440 aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct gttttgcagc 4500 agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct catatttgac 4560 aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca gcattgatgg 4620 tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt ctggaacgcc 4680 gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc gcgggattgt 4740 gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt catccgcccg 4800 cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg aacttaatgt 4860 cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg cttcctcccc 4920 tcccaatgcg gtttaaaaca caacttttct atacaaagtt gtaaataaaa aaccagactc 4980 tgtttggatt tggatcaagc taagtgtctt gctgtcttta tttaggggtt ttgcgcgcgc 5040 ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct gtgtattttt tccaggacgt 5100 ggtaaaggtg actctggatg ttcagataca tgggcataag cccgtctctg gggtggaggt 5160 agcaccactg cagagcttca tgctgcgggg tggtgttgta gatgatccag tcgtagcagg 5220 agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa gctgattgcc aggggcaggc 5280 ccttggtgta agtgtttaca aagcggttaa gctgggatgg gtgcatacgt ggggatatga 5340 gatgcatctt ggactgtatt tttaggttgg ctatgttccc agccatatcc ctccggggat 5400 tcatgttgtg cagaaccacc agcacagtgt atccggtgca cttgggaaat ttgtcatgta 5460 gcttagaagg aaatgcgtgg aagaacttgg agacgccctt gtgacctcca agattttcca 5520 tgcattcgtc cataatgatg gcaatgggcc cacgggcggc ggcctgggcg aagatatttc 5580 tgggatcact aacgtcatag ttgtgttcca ggatgagatc gtcataggcc atttttacaa 5640 agcgcgggcg gagggtgcca gactgcggta taatggttcc atccggccca ggggcgtagt 5700 taccctcaca gatttgcatt tcccacgctt tgagttcaga tggggggatc atgtctacct 5760 gcggggcgat gaagaaaacg gtttccgggg taggggagat cagctgggaa gaaagcaggt 5820 tcctgagcag ctgcgactta ccgcagccgg tgggcccgta aatcacacct attaccggct 5880 gcaactggta gttaagagag ctgcagctgc cgtcatccct gagcaggggg gccacttcgt 5940 taagcatgtc cctgactcgc atgttttccc tgaccaaatc cgccagaagg cgctcgccgc 6000 ccagcgatag cagttcttgc aaggaagcaa agtttttcaa cggtttgaga ccgtccgccg 6060 taggcatgct tttgagcgtt tgaccaagca gttccaggcg gtcccacagc tcggtcacct 6120 gctctacggc atctcgatcc agcatatctc ctcgtttcgc gggttggggc ggctttcgct 6180 gtacggcagt agtcggtgct cgtccagacg ggccagggtc atgtctttcc acgggcgcag 6240 ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc gctccgggct gcgcgctggc 6300 cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc tgccggtctt cgccctgcgc 6360 gtcggccagg tagcatttga ccatggtgtc atagtccagc ccctccgcgg cgtggccctt 6420 ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg cagtgcagac ttttgagggc 6480 gtagagcttg ggcgcgagaa ataccgattc cggggagtag gcatccgcgc cgcaggcccc 6540 gcagacggtc tcgcattcca cgagccaggt gagctctggc cgttcggggt caaaaaccag 6600 gtttccccca tgctttttga tgcgtttctt acctctggtt tccatgagcc ggtgtccacg 6660 ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac ttgagaggcc tgtcctcgag 6720 cggtgttccg cggtcctcct cgtatagaaa ctcggaccac tctgagacaa aggctcgcgt 6780 ccaggccagc acgaaggagg ctaagtggga ggggtagcgg tcgttgtcca ctagggggtc 6840 cactcgctcc agggtgtgaa gacacatgtc gccctcttcg gcatcaagga aggtgattgg 6900 tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg gggctataaa agggggtggg 6960 ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg agggccagct gttggggtga 7020 gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga ttgtcagttt ccaaaaacga 7080 ggaggatttg atattcacct ggcccgcggt gatgcctttg agggtggccg catccatctg 7140 gtcagaaaag acaatctttt tgttgtcaag cttggtggca aacgacccgt agagggcgtt 7200 ggacagcaac ttggcgatgg agcgcagggt ttggtttttg tcgcgatcgg cgcgctcctt 7260 ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac cgccattcgg gaaagacggt 7320 ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg ttgtgcaggg tgacaaggtc 7380 aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc cagcagaggc ggccgccctt 7440 gcgcgagcag aatggcggta gggggtctag ctgcgtctcg tccggggggt ctgcgtccac 7500 ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct atcttgcatc cttgcaagtc 7560 tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg tatgggttga gtgggggacc 7620 ccatggcatg gggtgggtga gcgcggaggc gtacatgccg caaatgtcgt aaacgtagag 7680 gggctctctg agtattccaa gatatgtagg gtagcatctt ccaccgcgga tgctggcgcg 7740 cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg ggaccgaggt tgctacgggc 7800 gggctgctct gctcggaaga ctatctgcct gaagatggca tgtgagttgg atgatatggt 7860 tggacgctgg aagacgttga agctggcgtc tgtgagacct accgcgtcac gcacgaagga 7920 ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg acctgcacgt ctagggcgca 7980 gtagtccagg gtttccttga tgatgtcata cttatcctgt cccttttttt tccacagctc 8040 gcggttgagg acaaactctt cgcggtcttt ccagtactct tggatcggaa acccgtcggc 8100 ctccgaacgg taagagccta gcatgtagaa ctggttgacg gcctggtagg cgcagcatcc 8160 cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg agcgaggtgt gggtgagcgc 8220 aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg aagtcagtgt cgtcgcatcc 8280 gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa cgcggatttg gcagggcgaa 8340 ggtgacatcg ttgaagagta tctttcccgc gcgaggcata aagttgcgtg tgatgcggaa 8400 gggtcccggc acctcggaac ggttgttaat tacctgggcg gcgagcacga tctcgtcaaa 8460 gccgttgatg ttgtggccca caatgtaaag ttccaagaag cgcgggatgc ccttgatgga 8520 aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg gagctgagcc cgtgctctga 8580 aagggcccag tctgcaagat gagggttgga agcgacgaat gagctccaca ggtcacgggc 8640 cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg cgacctatgg ccattttttc 8700 tggggtgatg cagtagaagg taagcgggtc ttgttcccag cggtcccatc caaggttcgc 8760 ggctaggtct cgcgcggcag tcactagagg ctcatctccg ccgaacttca tgaccagcat 8820 gaagggcacg agctgcttcc caaaggcccc catccaagta taggtctcta catcgtaggt 8880 gacaaagaga cgctcggtgc gaggatgcga gccgatcggg aagaactgga tctcccgcca 8940 ccaattggag gagtggctat tgatgtggtg aaagtagaag tccctgcgac gggccgaaca 9000 ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag cggtgcacgg gctgtacatc 9060 ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag agtgggaatt tgagcccctc 9120 gcctggcggg tttggctggt ggtcttctac ttcggctgct tgtccttgac cgtctggctg 9180 ctcgagggga gttacggtgg atcggaccac cacgccgcgc gagcccaaag tccagatgtc 9240 cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga tgggagctgt ccatggtctg 9300 gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg tttacctcgc atagacgggt 9360 cagggcgcgg gctagatcca ggtgatacct aatttccagg ggctggttgg tggcggcgtc 9420 gatggcttgc aagaggccgc atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg 9480 ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt gacgcgggcg agcccccgga 9540 ggtagggggg gctccggacc cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg 9600 ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc 9660 tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag 9720 agttcgacag aatcaatttc ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg 9780 tctcctgagt tgtcttgata ggcgatctcg gccatgaact gctcgatctc ttcctcctgg 9840 agatctccgc gtccggctcg ctccacggtg gcggcgaggt cgttggaaat gcgggccatg 9900 agctgcgaga aggcgttgag gcctccctcg ttccagacgc ggctgtagac cacgccccct 9960 tcggcatcgc gggcgcgcat gaccacctgc gcgagattga gctccacgtg ccgggcgaag 10020 acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc 10080 acgaagaagt acataaccca gcgtcgcaac gtggattcgt tgatatcccc caaggcctca 10140 aggcgctcca tggcctcgta gaagtccacg gcgaagttga aaaactggga gttgcgcgcc 10200 gacacggtta actcctcctc cagaagacgg atgagctcgg cgacagtgtc gcgcacctcg 10260 cgctcaaagg ctacaggggc ctcttcttct tcttcaatct cctcttccat aagggcctcc 10320 ccttcttctt cttctggcgg cggtggggga ggggggacac ggcggcgacg acggcgcacc 10380 gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc gacggcgcat ggtctcggtg 10440 acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc cgcccgtcat gtcccggtta 10500 tgggttggcg gggggctgcc atgcggcagg gatacggcgc taacgatgca tctcaacaat 10560 tgttgtgtag gtactccgcc gccgagggac ctgagcgagt ccgcatcgac cggatcggaa 10620 aacctctcga gaaaggcgtc taaccagtca cagtcgcaag gtaggctgag caccgtggcg 10680 ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg tgctgctgat gatgtaatta 10740 aagtaggcgg tcttgagacg gcggatggtc gacagaagca ccatgtcctt gggtccggcc 10800 tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt tttgacatcg gcgcaggtct 10860 ttgtagtagt cttgcatgag cctttctacc ggcacttctt cttctccttc ctcttgtcct 10920 gcatctcttg catctatcgc tgcggcggcg gcggagtttg gccgtaggtg gcgccctctt 10980 cctcccatgc gtgtgacccc gaagcccctc atcggctgaa gcagggctag gtcggcgaca 11040 acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg tagactggaa gtcatccatg 11100 tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag tgcagttggc cataacggac 11160 cagttaacgg tctggtgacc cggctgcgag agctcggtgt acctgagacg cgagtaagcc 11220 ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt actggtatcc caccaaaaag 11280 tgcggcggcg gctggcggta gaggggccag cgtagggtgg ccggggctcc gggggcgaga 11340 tcttccaaca taaggcgatg atatccgtag atgtacctgg acatccaggt gatgccggcg 11400 gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc agatgttgcg cagcggcaaa 11460 aagtgctcca tggtcgggac gctctggccg gtcaggcgcg cgcaatcgtt gacgctctag 11520 accgtgcaaa aggagagcct gtaagcgggc actcttccgt ggtctggtgg ataaattcgc 11580 aagggtatca tggcggacga ccggggttcg agccccgtat ccggccgtcc gccgtgatcc 11640 atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg tcagacaacg ggggagtgct 11700 ccttttggct tccttccagg cgcggcggct gctgcgctag cttttttggc cactggccgc 11760 gcgcagcgta agcggttagg ctggaaagcg aaagcattaa gtggctcgct ccctgtagcc 11820 ggagggttat tttccaaggg ttgagtcgcg ggacccccgg ttcgagtctc ggaccggccg 11880 gactgcggcg aacgggggtt tgcctccccg tcatgcaaga ccccgcttgc aaattcctcc 11940 ggaaacaggg acgagcccct tttttgcttt tcccagatgc atccggtgct gcggcagatg 12000 cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc agacatgcag ggcaccctcc 12060 cctcctccta ccgcgtcagg aggggcgaca tccgcggttg acgcggcagc agatggtgat 12120 tacgaacccc cgcggcgccg ggcccggcac tacctggact tggaggaggg cgagggcctg 12180 gcgcggctag gagcgccctc tcctgagcgg cacccaaggg tgcagctgaa gcgtgatacg 12240 cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc gcgagggaga ggagcccgag 12300 gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc ggcatggcct gaatcgcgag 12360 cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa ccgggattag tcccgcgcgc 12420 gcacacgtgg cggccgccga cctggtaacc gcatacgagc agacggtgaa ccaggagatt 12480 aactttcaaa aaagctttaa caaccacgtg cgtacgcttg tggcgcgcga ggaggtggct 12540 ataggactga tgcatctgtg ggactttgta agcgcgctgg agcaaaaccc aaatagcaag 12600 ccgctcatgg cgcagctgtt ccttatagtg cagcacagca gggacaacga ggcattcagg 12660 gatgcgctgc taaacatagt agagcccgag ggccgctggc tgctcgattt gataaacatc 12720 ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg ctgacaaggt ggccgccatc 12780 aactattcca tgcttagcct gggcaagttt tacgcccgca agatatacca taccccttac 12840 gttcccatag acaaggaggt aaagatcgag gggttctaca tgcgcatggc gctgaaggtg 12900 cttaccttga gcgacgacct gggcgtttat cgcaacgagc gcatccacaa ggccgtgagc 12960 gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc acagcctgca aagggccctg 13020 gctggcacgg gcagcggcga tagagaggcc gagtcctact ttgacgcggg cgctgacctg 13080 cgctgggccc caagccgacg cgccctggag gcagctgggg ccggacctgg gctggcggtg 13140 gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat atgacgagga cgatgagtac 13200 gagccagagg acggcgagta ctaagcggtg atgtttctga tcagatgatg caagacgcaa 13260 cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc cggccttaac tccacggacg 13320 actggcgcca ggtcatggac cgcatcatgt cgctgactgc gcgcaatcct gacgcgttcc 13380 ggcagcagcc gcaggccaac cggctctccg caattctgga agcggtggtc ccggcgcgcg 13440 caaaccccac gcacgagaag gtgctggcga tcgtaaacgc gctggccgaa aacagggcca 13500 tccggcccga cgaggccggc ctggtctacg acgcgctgct tcagcgcgtg gctcgttaca 13560 acagcggcaa cgtgcagacc aacctggacc ggctggtggg ggatgtgcgc gaggccgtgg 13620 cgcagcgtga gcgcgcgcag cagcagggca acctgggctc catggttgca ctaaacgcct 13680 tcctgagtac acagcccgcc aacgtgccgc ggggacagga ggactacacc aactttgtga 13740 gcgcactgcg gctaatggtg actgagacac cgcaaagtga ggtgtaccag tctgggccag 13800 actatttttt ccagaccagt agacaaggcc tgcagaccgt aaacctgagc caggctttca 13860 aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg cgaccgcgcg accgtgtcta 13920 gcttgctgac gcccaactcg cgcctgttgc tgctgctaat agcgcccttc acggacagtg 13980 gcagcgtgtc ccgggacaca tacctaggtc acttgctgac actgtaccgc gaggccatag 14040 gtcaggcgca tgtggacgag catactttcc aggagattac aagtgtcagc cgcgcgctgg 14100 ggcaggagga cacgggcagc ctggaggcaa ccctaaacta cctgctgacc aaccggcggc 14160 agaagatccc ctcgttgcac agtttaaaca gcgaggagga gcgcattttg cgctacgtgc 14220 agcagagcgt gagccttaac ctgatgcgcg acggggtaac gcccagcgtg gcgctggaca 14280 tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa ccggccgttt atcaaccgcc 14340 taatggacta cttgcatcgc gcggccgccg tgaaccccga gtatttcacc aatgccatct 14400 tgaacccgca ctggctaccg ccccctggtt tctacaccgg gggattcgag gtgcccgagg 14460 gtaacgatgg attcctctgg gacgacatag acgacagcgt gttttccccg caaccgcaga 14520 ccctgctaga gttgcaacag cgcgagcagg cagaggcggc gctgcgaaag gaaagcttcc 14580 gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc gcggtcagat gctagtagcc 14640 catttccaag cttgataggg tctcttacca gcactcgcac cacccgcccg cgcctgctgg 14700 gcgaggagga gtacctaaac aactcgctgc tgcagccgca gcgcgaaaaa aacctgcctc 14760 cggcatttcc caacaacggg atagagagcc tagtggacaa gatgagtaga tggaagacgt 14820 acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc cacccgtcgt caaaggcacg 14880 accgtcagcg gggtctggtg tgggaggacg atgactcggc agacgacagc agcgtcctgg 14940 atttgggagg gagtggcaac ccgtttgcgc accttcgccc caggctgggg agaatgtttt 15000 aaaaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg gcaccgagcg 15060 ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg aaggtcctcc 15120 tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg gttctccctt 15180 cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta ccggggggag 15240 aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg tgtacctggt 15300 ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca gcaactttct 15360 gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac agaccatcaa 15420 tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata ccaacatgcc 15480 aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg tgtcgcgctt 15540 gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca cgctgcccga 15600 gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg tggagcacta 15660 cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa agtttgacac 15720 ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg gggtatatac 15780 aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg acttcaccca 15840 cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg agggctttag 15900 gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg tggacgccta 15960 ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg gcagcaacag 16020 cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc agccggtgga 16080 ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg aggagaagcg 16140 cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg aggtcgagaa 16200 gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac gcagttacaa 16260 cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg catacaacta 16320 cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg acgtaacctg 16380 cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg tgaccttccg 16440 ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc ccgtgcactc 16500 caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt ttacctctct 16560 gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc cagcccccac 16620 catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc taccgctgcg 16680 caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc gcacctgccc 16740 ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc gcactttttg 16800 agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc tgcgcttccc 16860 aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc gcgtgcgcgg 16920 gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca ccaccgtcga 16980 tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc cgccaccagt 17040 gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct atgctaaaat 17100 gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca ctgccgccca 17160 acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg cggccatgcg 17220 ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca ggcgacgagc 17280 ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg gcaacgtgta 17340 ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc ccccgcgcaa 17400 ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag cggcggcggc 17460 gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg tcatcgcgcc 17520 ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa agctaaagcg 17580 ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg aactgctgca 17640 cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac gtgttttgcg 17700 acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct acaagcgcgt 17760 gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc gcctcgggga 17820 gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg agggcaaccc 17880 aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg caccgtccga 17940 agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc agctgatggt 18000 acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac ctgggctgga 18060 gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg tgcagaccgt 18120 ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag agggcatgga 18180 gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg cggtcgctgc 18240 ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc gcgtttcagc 18300 cccccggcgc ccgcgccgtt cgaggaagta cggcgccgcc agcgcgctac tgcccgaata 18360 tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct accgccccag 18420 aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc gtcgccgtcg 18480 ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag gcaggaccct 18540 ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct ttgtggttct 18600 tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc gaggaagaat 18660 gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc gtgcgcacca 18720 ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc tccttattcc 18780 actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct tgcaggcgca 18840 gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt ctggactctc 18900 acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt gcgtctctgg 18960 ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc accagcaata 19020 tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat ttcggttcca 19080 ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg ctgagggata 19140 agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct ggcattagcg 19200 gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag cttgatcccc 19260 gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag gggcgtggcg 19320 aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac gagcctccct 19380 cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg cccatggcta 19440 ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc gccgacaccc 19500 agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct agccgcgcgt 19560 ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt ggcaactggc 19620 aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc cgacgatgct 19680 tctgaatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc gccagaggag 19740 ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga tgccgcagtg 19800 gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg ggctggtgca 19860 gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa accccacggt 19920 ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc ggttcatccc 19980 tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag ctgtgggtga 20040 taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc tggacagggg 20100 ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca agggtgcccc 20160 aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag aagaagagga 20220 cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc acgtatttgg 20280 gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag gtgtcgaagg 20340 tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag gagaatctca 20400 gtggtacgaa actgaaatta atcatgcagc tgggagagtc cttaaaaaga ctaccccaat 20460 gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc aaggcattct 20520 tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt tctcaactac 20580 tgaggcgacc gcaggcaatg gtgataactt gactcctaaa gtggtattgt acagtgaaga 20640 tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta aggaaggtaa 20700 ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca ttgcttttag 20760 ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg ttctggcggg 20820 ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag agctttcata 20880 ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt ggaatcaggc 20940 tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg aagatgaact 21000 tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta ccaaggtaaa 21060 acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt cagataaaaa 21120 tgaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca acctgtggag 21180 aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt acagtccttc 21240 caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc gagtggtggc 21300 tcccgggtta gtggactgct acattaacct tggagcacgc tggtcccttg actatatgga 21360 caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct caatgttgct 21420 gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct ttgccattaa 21480 aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga aggatgttaa 21540 catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca gcattaagtt 21600 tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg cctccacgct 21660 tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc tctccgccgc 21720 caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca tcccctcccg 21780 caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg aaaccccatc 21840 actgggctcg ggctacgacc cttattacac ctactctggc tctataccct acctagatgg 21900 aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact cttctgtcag 21960 ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc gctcagttga 22020 cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc tggtacaaat 22080 gctagctaac tacaacattg gctaccaggg cttctatatc ccagagagct acaaggaccg 22140 catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg atgatactaa 22200 atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg gatttgttgg 22260 ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc cctatccgct 22320 tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg atcgcaccct 22380 ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag acctgggcca 22440 aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg tggatcccat 22500 ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc gtgtgcaccg 22560 gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg ccggcaacgc 22620 cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc cagtgagcag 22680 gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg cacctatgac 22740 aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt caatacggcc 22800 ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca ctcaaaaaca 22860 tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt ttaccagttt 22920 gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg ctgtataacg 22980 ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg actattctgc 23040 tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca caaccccacc 23100 atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt acagcccacc 23160 ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc ctacttccgc 23220 agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa catgtaaaaa 23280 taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac tctcgggtga 23340 ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt ctgccgcgca 23400 tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct ccacttaaac 23460 tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct gcgcaccatc 23520 accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg gcctccgccc 23580 tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag cgccgggtgg 23640 tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc ctccgcgttg 23700 ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc gtgcccaggc 23760 tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt ctgggcgtta 23820 ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc ctttgcgcct 23880 tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca ggccgcgtcg 23940 tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc ccaccggttc 24000 ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt ttcgctcgtc 24060 acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag acacttaagc 24120 tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg ctcgtgatgc 24180 ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc catcatcgtc 24240 acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc gttcagccag 24300 gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa gttcgccttt 24360 agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat gcccttctcc 24420 cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact ttccgcttcg 24480 ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc gtcttcattc 24540 agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg tgggttgctg 24600 aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac gattacctct 24660 ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt gggcgcaatg 24720 gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac cagcgcgtct 24780 tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt ttttgggggc 24840 gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt tgggggacgt 24900 cgcgccgcac cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc ccgactggcc 24960 atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa ggacagccta 25020 accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc gcctaccacc 25080 ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca ggacccaggt 25140 tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa gcaagaccag 25200 gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca tggcgactac 25260 ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc cattatctgc 25320 gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag ccttgcctac 25380 gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg cacatgcgag 25440 cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct tgccacctat 25500 cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg cagccgagcg 25560 gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc gctcaacgaa 25620 gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa cgctctgcaa 25680 caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga gggtgacaac 25740 gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta cccggcactt 25800 aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg ccgtgcgcag 25860 cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc cgcagttggc 25920 gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga ggagcgacgc 25980 aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca gcggttcttt 26040 gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt tcgacagggc 26100 tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt ctcctacctt 26160 ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct caagggcgag 26220 gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac ctggcagacg 26280 gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct gcagaaactg 26340 ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt ggccgcgcac 26400 ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg tctgccagac 26460 ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg ctcaggaatc 26520 ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta ccgcgaatgc 26580 cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct tgcctaccac 26640 tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg tcgctgcaac 26700 ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga aagtcaaatt 26760 atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc tccggggttg 26820 aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc tgaggactac 26880 cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccaaatgc ggagcttacc 26940 gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa caaagcccgc 27000 caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc cggcgaggag 27060 ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc ccttgcttcc 27120 caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg aggaggaata 27180 ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga tggaagactg 27240 ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa caccgtcacc 27300 ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca gcatggctac 27360 aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc gtagatggga 27420 caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc aagagcaaca 27480 acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg cttgcttgca 27540 agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc acggcgtggc 27600 cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact gcaccggcgg 27660 cagcggcagc ggcagcaaca gcagcggcca cacagaagca aaggcgaccg gatagcaaga 27720 ctctgacaaa gcccaagaaa tccacagcgg cggcagcagc aggaggagga gcgctgcgtc 27780 tggcgcccaa cgaacccgta tcgacccgcg agcttagaaa caggattttt cccactctgt 27840 atgctatatt tcaacagagc aggggccaag aacaagagct gaaaataaaa aacaggtctc 27900 tgcgatccct cacccgcagc tgcctgtatc acaaaagcga agatcagctt cggcgcacgc 27960 tggaagacgc ggaggctctc ttcagtaaat actgcgcgct gactcttaag gactagtttc 28020 gcgccctttc tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca cacccggcgc 28080 cagcacctgt cgtcagcgcc atttcaactt tgtatacaaa agttgtgatg agcaaggaaa 28140 ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct ggagctgccc 28200 aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata tcccgggtca 28260 acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt accaccacac 28320 ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg 28380 ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg actaactcag 28440 gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag ggtataactc 28500 acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg 28560 gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca ttcacgcctc 28620 gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga ggcattggaa 28680 ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc tcgggacctc 28740 ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac tcggcggacg 28800 gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact 28860 gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt gaattgcccg 28920 aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga gagcttgccc 28980 gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac aggggaccct 29040 gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat ctttgttgcc 29100 atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc ctatcgccat 29160 cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt acctggtact 29220 tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt gagtctacga 29280 gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct tacctgccgg 29340 gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg taaaccagac 29400 tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc ttagaaaacc 29460 cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt caagcaactc 29520 tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc tctgtcttgt 29580 gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct gctgtgtgca 29640 catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat gattaggtac 29700 ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa ggtggatttt 29760 aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac cactcttata 29820 aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat tggcaagtat 29880 gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac agttttccag 29940 ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg cgacattacc 30000 atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga aaacactggc 30060 actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac cctactctat 30120 attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta atttactaag 30180 ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca aattcaaaaa 30240 gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct caataccatt 30300 cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg aagtcaggct 30360 tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt tccagtccaa 30420 ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc cgctaccgga 30480 cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg ggataacttg 30540 ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat gtggctcatc 30600 tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat tgtgctacac 30660 ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt ttctcttaca 30720 gtatgattaa atgagacatg attcctcgag tttttatatt actgaccctt gttgcgcttt 30780 tttgtgcgtg ctccacattg gctgcggttt ctcacatcga agtagactgc attccagcct 30840 tcacagtcta tttgctttac ggatttgtca ccctcacgct catctgcagc ctcatcactg 30900 tggtcatcgc ctttatccag tgcattgact gggtctgtgt gcgctttgca tatctcagac 30960 accatcccca gtacagggac aggactatag ctgagcttct tagaattctt taattatgaa 31020 atttactgtg acttttctgc tgattatttg caccctatct gcgttttgtt ccccgacctc 31080 caagcctcaa agacatatat catgcagatt cactcgtata tggaatattc caagttgcta 31140 caatgaaaaa agcgatcttt ccgaagcctg gttatatgca atcatctctg ttatggtgtt 31200 ctgcagtacc atcttagccc tagctatata tccctacctt gacattggct ggaacgcaat 31260 agatgccatg aaccacccaa ctttccccgc gcccgctatg cttccactgc aacaagttgt 31320 tgccggcggc tttgtcccag ccaatcagcc tcgcccacct tctcccaccc ccactgaaat 31380 cagctacttt aatctaacag gaggagatga ctgacaccct agatctagaa atggacggaa 31440 ttattacaga gcagcgcctg ctagaaagac gcagggcagc ggccgagcaa cagcgcatga 31500 atcaagagct ccaagacatg gttaacttgc accagtgcaa aaggggtatc ttttgtctgg 31560 taaagcaggc caaagtcacc tacgacagta ataccaccgg acaccgcctt agctacaagt 31620 tgccaaccaa gcgtcagaaa ttggtggtca tggtgggaga aaagcccatt accataactc 31680 agcactcggt agaaaccgaa ggctgcattc actcaccttg tcaaggacct gaggatctct 31740 gcacccttat taagaccctg tgcggtctca aagatcttat tccctttaac taataaaaaa 31800 aaataataaa gcatcactta cttaaaatca gttagcaaat ttctgtccag tttattcagc 31860 agcacctcct tgccctcctc ccagctctgg tattgcagct tcctcctggc tgcaaacttt 31920 ctccacaatc taaatggaat gtcagtttcc tcctgttcct gtccatccgc acccactatc 31980 ttcatgttgt tgcagatgaa gcgcgcaaga ccgtctgaag ataccttcaa ccccgtgtat 32040 ccatatgaca cggaaaccgg tcctccaact gtgccttttc ttactcctcc ctttgtatcc 32100 cccaatgggt ttcaagagag tccccctggg gtactctctt tgcgcctatc cgaacctcta 32160 gttacctcca atggcatgct tgcgctcaaa atgggcaacg gcctctctct ggacgaggcc 32220 ggcaacctta cctcccaaaa tgtaaccact gtgagcccac ctctcaaaaa aaccaagtca 32280 aacataaacc tggaaatatc tgcacccctc acagttacct cagaagccct aactgtggct 32340 gccgccgcac ctctaatggt cgcgggcaac acactcacca tgcaatcaca ggccccgcta 32400 accgtgcacg actccaaact tagcattgcc acccaaggac ccctcacagt gtcagaagga 32460 aagctagccc tgcaaacatc aggccccctc accaccaccg atagcagtac ccttactatc 32520 actgcctcac cccctctaac tactgccact ggtagcttgg gcattgactt gaaagagccc 32580 atttatacac aaaatggaaa actaggacta aagtacgggg ctcctttgca tgtaacagac 32640 gacctaaaca ctttgaccgt agcaactggt ccaggtgtga ctattaataa tacttccttg 32700 caaactaaag ttactggagc cttgggtttt gattcacaag gcaatatgca acttaatgta 32760 gcaggaggac taaggattga ttctcaaaac agacgcctta tacttgatgt tagttatccg 32820 tttgatgctc aaaaccaact aaatctaaga ctaggacagg gccctctttt tataaactca 32880 gcccacaact tggatattaa ctacaacaaa ggcctttact tgtttacagc ttcaaacaat 32940 tccaaaaagc ttgaggttaa cctaagcact gccaaggggt tgatgtttga cgctacagcc 33000 atagccatta atgcaggaga tgggcttgaa tttggttcac ctaatgcacc aaacacaaat 33060 cccctcaaaa caaaaattgg ccatggccta gaatttgatt caaacaaggc tatggttcct 33120 aaactaggaa ctggccttag ttttgacagc acaggtgcca ttacagtagg aaacaaaaat 33180 aatgataagc taactttgtg gaccacacca gctccatctc ctaactgtag actaaatgca 33240 gagaaagatg ctaaactcac tttggtctta acaaaatgtg gcagtcaaat acttgctaca 33300 gtttcagttt tggctgttaa aggcagtttg gctccaatat ctggaacagt tcaaagtgct 33360 catcttatta taagatttga cgaaaatgga gtgctactaa acaattcctt cctggaccca 33420 gaatattgga actttagaaa tggagatctt actgaaggca cagcctatac aaacgctgtt 33480 ggatttatgc ctaacctatc agcttatcca aaatctcacg gtaaaactgc caaaagtaac 33540 attgtcagtc aagtttactt aaacggagac aaaactaaac ctgtaacact aaccattaca 33600 ctaaacggta cacaggaaac aggagacaca actccaagtg catactctat gtcattttca 33660 tgggactggt ctggccacaa ctacattaat gaaatatttg ccacatcctc ttacactttt 33720 tcatacattg cccaagaata aagaatcgtt tgtgttatgt ttcaacgtgt ttatttttca 33780 attgcagaaa atttcaagtc atttttcatt cagtagtata gccccaccac cacatagctt 33840 atacagatca ccgtacctca actttgtata ataaagttgt aatcaaactc acagaaccct 33900 agtattcaac ctgccacctc cctcccaaca cacagagtac acagtccttt ctccccggct 33960 ggccttaaaa agcatcatat catgggtaac agacatattc ttaggtgtta tattccacac 34020 ggtttcctgt cgagccaaac gctcatcagt gatattaata aactccccgg gcagctcact 34080 taagttcatg tcgctgtcca gctgctgagc cacaggctgc tgtccaactt gcggttgctt 34140 aacgggcggc gaaggagaag tccacgccta catgggggta gagtcataat cgtgcatcag 34200 gatagggcgg tggtgctgca gcagcgcgcg aataaactgc tgccgccgcc gctccgtcct 34260 gcaggaatac aacatggcag tggtctcctc agcgatgatt cgcaccgccc gcagcataag 34320 gcgccttgtc ctccgggcac agcagcgcac cctgatctca cttaaatcag cacagtaact 34380 gcagcacagc accacaatat tgttcaaaat cccacagtgc aaggcgctgt atccaaagct 34440 catggcgggg accacagaac ccacgtggcc atcataccac aagcgcaggt agattaagtg 34500 gcgacccctc ataaacacgc tggacataaa cattacctct tttggcatgt tgtaattcac 34560 cacctcccgg taccatataa acctctgatt aaacatggcg ccatccacca ccatcctaaa 34620 ccagctggcc aaaacctgcc cgccggctat acactgcagg gaaccgggac tggaacaatg 34680 acagtggaga gcccaggact cgtaaccatg gatcatcatg ctcgtcatga tatcaatgtt 34740 ggcacaacac aggcacacgt gcatacactt cctcaggatt acaagctcct cccgcgttag 34800 aaccatatcc cagggaacaa cccattcctg aatcagcgta aatcccacac tgcagggaag 34860 acctcgcacg taactcacgt tgtgcattgt caaagtgtta cattcgggca gcagcggatg 34920 atcctccagt atggtagcgc gggtttctgt ctcaaaagga ggtagacgat ccctactgta 34980 cggagtgcgc cgagacaacc gagatcgtgt tggtcgtagt gtcatgccaa atggaacgcc 35040 ggacgtagtc atatttcctg aagcaaaacc aggtgcgggc gtgacaaaca gatctgcgtc 35100 tccggtctcg ccgcttagat cgctctgtgt agtagttgta gtatatccac tctctcaaag 35160 catccaggcg ccccctggct tcgggttcta tgtaaactcc ttcatgcgcc gctgccctga 35220 taacatccac caccgcagaa taagccacac ccagccaacc tacacattcg ttctgcgagt 35280 cacacacggg aggagcggga agagctggaa gaaccatgtt ttttttttta ttccaaaaga 35340 ttatccaaaa cctcaaaatg aagatctatt aagtgaacgc gctcccctcc ggtggcgtgg 35400 tcaaactcta cagccaaaga acagataatg gcatttgtaa gatgttgcac aatggcttcc 35460 aaaaggcaaa cggccctcac gtccaagtgg acgtaaaggc taaacccttc agggtgaatc 35520 tcctctataa acattccagc accttcaacc atgcccaaat aattctcatc tcgccacctt 35580 ctcaatatat ctctaagcaa atcccgaata ttaagtccgg ccattgtaaa aatctgctcc 35640 agagcgccct ccaccttcag cctcaagcag cgaatcatga ttgcaaaaat tcaggttcct 35700 cacagacctg tataagattc aaaagcggaa cattaacaaa aataccgcga tcccgtaggt 35760 cccttcgcag ggccagctga acataatcgt gcaggtctgc acggaccagc gcggccactt 35820 ccccgccagg aaccatgaca aaagaaccca cactgattat gacacgcata ctcggagcta 35880 tgctaaccag cgtagccccg atgtaagctt gttgcatggg cggcgatata aaatgcaagg 35940 tgctgctcaa aaaatcaggc aaagcctcgc gcaaaaaaga aagcacatcg tagtcatgct 36000 catgcagata aaggcaggta agctccggaa ccaccacaga aaaagacacc atttttctct 36060 caaacatgtc tgcgggtttc tgcataaaca caaaataaaa taacaaaaaa acatttaaac 36120 attagaagcc tgtcttacaa caggaaaaac aacccttata agcataagac ggactacggc 36180 catgccggcg tgaccgtaaa aaaactggtc accgtgatta aaaagcacca ccgacagctc 36240 ctcggtcatg tccggagtca taatgtaaga ctcggtaaac acatcaggtt gattcacatc 36300 ggtcagtgct aaaaagcgac cgaaatagcc cgggggaata catacccgca ggcgtagaga 36360 caacattaca gcccccatag gaggtataac aaaattaata ggagagaaaa acacataaac 36420 acctgaaaaa ccctcctgcc taggcaaaat agcaccctcc cgctccagaa caacatacag 36480 cgcttccaca gcggcagcca taacagtcag ccttaccagt aaaaaagaaa acctattaaa 36540 aaaacaccac tcgacacggc accagctcaa tcagtcacag tgtaaaaaag ggccaagtgc 36600 agagcgagta tatataggac taaaaaatga cgtaacggtt aaagtccaca aaaaacaccc 36660 agaaaaccgc acgcgaacct acgcccagaa acgaaagcca aaaaacccac aacttcctca 36720 aatcgtcact tccgttttcc cacgttacgt cacttcccat tttaagaaaa ctacaattcc 36780 caacacatac aagttactcc gccctaaaac ctacgtcacc cgccccgttc ccacgccccg 36840 cgccacgtca caaactccac cccctcatta tcatattggc ttcaatccaa aataaggtat 36900 attattgatg atg 36913 <210> 29 <211> 36913 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO171) <400> 29 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattaaac cgtattaccg ccatgcattt aatggagtgc 480 ctcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa 540 gttgggggga ggggtcggca attgaaccgg tgcctagaga aggtggcgcg gggtaaactg 600 ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat 660 aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacaggt 720 aagtgccgtg tgtggttccc gcgggcctgg cctctttacg ggttatggcc cttgcgtgcc 780 ttgaattact tccacctggc tgcagtacgt gattcttgat cccgagcttc gggttggaag 840 tgggtgggag agttcgaggc cttgcgctta aggagcccct tcgcctcgtg cttgagttga 900 ggcctggcct gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct 960 cgctgctttc gataagtctc tagccattta aaatttttga tgacctgctg cgacgctttt 1020 tttctggcaa gatagtcttg taaatgcggg ccaagatctg cacactggta tttcggtttt 1080 tggggccgcg ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg 1140 cctgcgagcg cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct 1200 ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc 1260 ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag ggagctcaaa 1320 atggaggacg cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc 1380 ctttccgtcc tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca 1440 cctcgattag ttctcgagct tttggagtac gtcgtcttta ggttgggggg aggggtttta 1500 tgcgatggag tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt 1560 gatgtaattc tccttggaat ttgccctttt tgagtttgga tcttggttca ttctcaagcc 1620 tcagacagtg gttcaaagtt tttttcttcc atttcaggtg tcgtgacgct agcgctaccg 1680 gactcagatc tcgagctcaa gcttcgaatt ctgcagtcga cggtaccgga tccatggaag 1740 acgccaaaaa cataaagaaa ggcccggcgc cattctatcc gctggaagat ggaaccgctg 1800 gagagcaact gcataaggct atgaagagat acgccctggt tcctggaaca attgctttta 1860 cagatgcaca tatcgaggtg gacatcactt acgctgagta cttcgaaatg tccgttcggt 1920 tggcagaagc tatgaaacga tatgggctga atacaaatca cagaatcgtc gtatgcagtg 1980 aaaactctct tcaattcttt atgccggtgt tgggcgcgtt atttatcgga gttgcagttg 2040 cgcccgcgaa cgacatttat aatgaacgtg aattgctcaa cagtatgggc atttcgcagc 2100 ctaccgtggt gttcgtttcc aaaaaggggt tgcaaaaaat tttgaacgtg caaaaaaagc 2160 tcccaatcat ccaaaaaatt attatcatgg attctaaaac ggattaccag ggatttcagt 2220 cgatgtacac gttcgtcaca tctcatctac ctcccggttt taatgaatac gattttgtgc 2280 cagagtcctt cgatagggac aagacaattg cactgatcat gaactcctct ggatctactg 2340 gtctgcctaa aggtgtcgct ctgcctcata gaactgcctg cgtgagattc tcgcatgcca 2400 gagatcctat ttttggcaat caaatcattc cggatactgc gattttaagt gttgttccat 2460 tccatcacgg ttttggaatg tttactacac tcggatattt gatatgtgga tttcgagtcg 2520 tcttaatgta tagatttgaa gaagagctgt ttctgaggag ccttcaggat tacaagattc 2580 aaagtgcgct gctggtgcca accctattct ccttcttcgc caaaagcact ctgattgaca 2640 aatacgattt atctaattta cacgaaattg cttctggtgg cgctcccctc tctaaggaag 2700 tcggggaagc ggttgccaag aggttccatc tgccaggtat caggcaagga tatgggctca 2760 ctgagactac atcagctatt ctgattacac ccgaggggga tgataaaccg ggcgcggtcg 2820 gtaaagttgt tccatttttt gaagcgaagg ttgtggatct ggataccggg aaaacgctgg 2880 gcgttaatca aagaggcgaa ctgtgtgtga gaggtcctat gattatgtcc ggttatgtaa 2940 acaatccgga agcgaccaac gccttgattg acaaggatgg atggctacat tctggagaca 3000 tagcttactg ggacgaagac gaacacttct tcatcgttga ccgcctgaag tctctgatta 3060 agtacaaagg ctatcaggtg gctcccgctg aattggaatc catcttgctc caacacccca 3120 acatcttcga cgcaggtgtc gcaggtcttc ccgacgatga cgccggtgaa cttcccgccg 3180 ccgttgttgt tttggagcac ggaaagacga tgacggaaaa agagatcgtg gattacgtcg 3240 ccagtcaagt aacaaccgcg aaaaagttgc gcggaggagt tgtgtttgtg gacgaagtac 3300 cgaaaggtct taccggaaaa ctcgacgcaa gaaaaatcag agagatcctc ataaaggcca 3360 agaagggcgg aaagatcgcc gtggcagccg cagccaccat ggtgagcaag ggcgaggagc 3420 tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt 3480 tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca 3540 tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg 3600 gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg 3660 ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca 3720 agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg 3780 gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca 3840 gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga 3900 tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc 3960 ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc 4020 tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg 4080 ccgggatcac tctcggcatg gacgagctgt acaagtaaag cgactctaga tcataatcag 4140 ccatacccaa acaccattgt cacactccaa tcgattcaaa caccattgtc acactccaac 4200 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4260 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4320 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4380 tttgtccaaa ctcatcaatg taagtttaaa cggcgcgcct gaaatgtgtg ggcgtggctt 4440 aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct gttttgcagc 4500 agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct catatttgac 4560 aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca gcattgatgg 4620 tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt ctggaacgcc 4680 gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc gcgggattgt 4740 gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt catccgcccg 4800 cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg aacttaatgt 4860 cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg cttcctcccc 4920 tcccaatgcg gtttaaaaca caacttttct atacaaagtt gtaaataaaa aaccagactc 4980 tgtttggatt tggatcaagc taagtgtctt gctgtcttta tttaggggtt ttgcgcgcgc 5040 ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct gtgtattttt tccaggacgt 5100 ggtaaaggtg actctggatg ttcagataca tgggcataag cccgtctctg gggtggaggt 5160 agcaccactg cagagcttca tgctgcgggg tggtgttgta gatgatccag tcgtagcagg 5220 agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa gctgattgcc aggggcaggc 5280 ccttggtgta agtgtttaca aagcggttaa gctgggatgg gtgcatacgt ggggatatga 5340 gatgcatctt ggactgtatt tttaggttgg ctatgttccc agccatatcc ctccggggat 5400 tcatgttgtg cagaaccacc agcacagtgt atccggtgca cttgggaaat ttgtcatgta 5460 gcttagaagg aaatgcgtgg aagaacttgg agacgccctt gtgacctcca agattttcca 5520 tgcattcgtc cataatgatg gcaatgggcc cacgggcggc ggcctgggcg aagatatttc 5580 tgggatcact aacgtcatag ttgtgttcca ggatgagatc gtcataggcc atttttacaa 5640 agcgcgggcg gagggtgcca gactgcggta taatggttcc atccggccca ggggcgtagt 5700 taccctcaca gatttgcatt tcccacgctt tgagttcaga tggggggatc atgtctacct 5760 gcggggcgat gaagaaaacg gtttccgggg taggggagat cagctgggaa gaaagcaggt 5820 tcctgagcag ctgcgactta ccgcagccgg tgggcccgta aatcacacct attaccggct 5880 gcaactggta gttaagagag ctgcagctgc cgtcatccct gagcaggggg gccacttcgt 5940 taagcatgtc cctgactcgc atgttttccc tgaccaaatc cgccagaagg cgctcgccgc 6000 ccagcgatag cagttcttgc aaggaagcaa agtttttcaa cggtttgaga ccgtccgccg 6060 taggcatgct tttgagcgtt tgaccaagca gttccaggcg gtcccacagc tcggtcacct 6120 gctctacggc atctcgatcc agcatatctc ctcgtttcgc gggttggggc ggctttcgct 6180 gtacggcagt agtcggtgct cgtccagacg ggccagggtc atgtctttcc acgggcgcag 6240 ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc gctccgggct gcgcgctggc 6300 cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc tgccggtctt cgccctgcgc 6360 gtcggccagg tagcatttga ccatggtgtc atagtccagc ccctccgcgg cgtggccctt 6420 ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg cagtgcagac ttttgagggc 6480 gtagagcttg ggcgcgagaa ataccgattc cggggagtag gcatccgcgc cgcaggcccc 6540 gcagacggtc tcgcattcca cgagccaggt gagctctggc cgttcggggt caaaaaccag 6600 gtttccccca tgctttttga tgcgtttctt acctctggtt tccatgagcc ggtgtccacg 6660 ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac ttgagaggcc tgtcctcgag 6720 cggtgttccg cggtcctcct cgtatagaaa ctcggaccac tctgagacaa aggctcgcgt 6780 ccaggccagc acgaaggagg ctaagtggga ggggtagcgg tcgttgtcca ctagggggtc 6840 cactcgctcc agggtgtgaa gacacatgtc gccctcttcg gcatcaagga aggtgattgg 6900 tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg gggctataaa agggggtggg 6960 ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg agggccagct gttggggtga 7020 gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga ttgtcagttt ccaaaaacga 7080 ggaggatttg atattcacct ggcccgcggt gatgcctttg agggtggccg catccatctg 7140 gtcagaaaag acaatctttt tgttgtcaag cttggtggca aacgacccgt agagggcgtt 7200 ggacagcaac ttggcgatgg agcgcagggt ttggtttttg tcgcgatcgg cgcgctcctt 7260 ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac cgccattcgg gaaagacggt 7320 ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg ttgtgcaggg tgacaaggtc 7380 aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc cagcagaggc ggccgccctt 7440 gcgcgagcag aatggcggta gggggtctag ctgcgtctcg tccggggggt ctgcgtccac 7500 ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct atcttgcatc cttgcaagtc 7560 tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg tatgggttga gtgggggacc 7620 ccatggcatg gggtgggtga gcgcggaggc gtacatgccg caaatgtcgt aaacgtagag 7680 gggctctctg agtattccaa gatatgtagg gtagcatctt ccaccgcgga tgctggcgcg 7740 cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg ggaccgaggt tgctacgggc 7800 gggctgctct gctcggaaga ctatctgcct gaagatggca tgtgagttgg atgatatggt 7860 tggacgctgg aagacgttga agctggcgtc tgtgagacct accgcgtcac gcacgaagga 7920 ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg acctgcacgt ctagggcgca 7980 gtagtccagg gtttccttga tgatgtcata cttatcctgt cccttttttt tccacagctc 8040 gcggttgagg acaaactctt cgcggtcttt ccagtactct tggatcggaa acccgtcggc 8100 ctccgaacgg taagagccta gcatgtagaa ctggttgacg gcctggtagg cgcagcatcc 8160 cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg agcgaggtgt gggtgagcgc 8220 aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg aagtcagtgt cgtcgcatcc 8280 gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa cgcggatttg gcagggcgaa 8340 ggtgacatcg ttgaagagta tctttcccgc gcgaggcata aagttgcgtg tgatgcggaa 8400 gggtcccggc acctcggaac ggttgttaat tacctgggcg gcgagcacga tctcgtcaaa 8460 gccgttgatg ttgtggccca caatgtaaag ttccaagaag cgcgggatgc ccttgatgga 8520 aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg gagctgagcc cgtgctctga 8580 aagggcccag tctgcaagat gagggttgga agcgacgaat gagctccaca ggtcacgggc 8640 cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg cgacctatgg ccattttttc 8700 tggggtgatg cagtagaagg taagcgggtc ttgttcccag cggtcccatc caaggttcgc 8760 ggctaggtct cgcgcggcag tcactagagg ctcatctccg ccgaacttca tgaccagcat 8820 gaagggcacg agctgcttcc caaaggcccc catccaagta taggtctcta catcgtaggt 8880 gacaaagaga cgctcggtgc gaggatgcga gccgatcggg aagaactgga tctcccgcca 8940 ccaattggag gagtggctat tgatgtggtg aaagtagaag tccctgcgac gggccgaaca 9000 ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag cggtgcacgg gctgtacatc 9060 ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag agtgggaatt tgagcccctc 9120 gcctggcggg tttggctggt ggtcttctac ttcggctgct tgtccttgac cgtctggctg 9180 ctcgagggga gttacggtgg atcggaccac cacgccgcgc gagcccaaag tccagatgtc 9240 cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga tgggagctgt ccatggtctg 9300 gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg tttacctcgc atagacgggt 9360 cagggcgcgg gctagatcca ggtgatacct aatttccagg ggctggttgg tggcggcgtc 9420 gatggcttgc aagaggccgc atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg 9480 ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt gacgcgggcg agcccccgga 9540 ggtagggggg gctccggacc cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg 9600 ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc 9660 tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag 9720 agttcgacag aatcaatttc ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg 9780 tctcctgagt tgtcttgata ggcgatctcg gccatgaact gctcgatctc ttcctcctgg 9840 agatctccgc gtccggctcg ctccacggtg gcggcgaggt cgttggaaat gcgggccatg 9900 agctgcgaga aggcgttgag gcctccctcg ttccagacgc ggctgtagac cacgccccct 9960 tcggcatcgc gggcgcgcat gaccacctgc gcgagattga gctccacgtg ccgggcgaag 10020 acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc 10080 acgaagaagt acataaccca gcgtcgcaac gtggattcgt tgatatcccc caaggcctca 10140 aggcgctcca tggcctcgta gaagtccacg gcgaagttga aaaactggga gttgcgcgcc 10200 gacacggtta actcctcctc cagaagacgg atgagctcgg cgacagtgtc gcgcacctcg 10260 cgctcaaagg ctacaggggc ctcttcttct tcttcaatct cctcttccat aagggcctcc 10320 ccttcttctt cttctggcgg cggtggggga ggggggacac ggcggcgacg acggcgcacc 10380 gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc gacggcgcat ggtctcggtg 10440 acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc cgcccgtcat gtcccggtta 10500 tgggttggcg gggggctgcc atgcggcagg gatacggcgc taacgatgca tctcaacaat 10560 tgttgtgtag gtactccgcc gccgagggac ctgagcgagt ccgcatcgac cggatcggaa 10620 aacctctcga gaaaggcgtc taaccagtca cagtcgcaag gtaggctgag caccgtggcg 10680 ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg tgctgctgat gatgtaatta 10740 aagtaggcgg tcttgagacg gcggatggtc gacagaagca ccatgtcctt gggtccggcc 10800 tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt tttgacatcg gcgcaggtct 10860 ttgtagtagt cttgcatgag cctttctacc ggcacttctt cttctccttc ctcttgtcct 10920 gcatctcttg catctatcgc tgcggcggcg gcggagtttg gccgtaggtg gcgccctctt 10980 cctcccatgc gtgtgacccc gaagcccctc atcggctgaa gcagggctag gtcggcgaca 11040 acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg tagactggaa gtcatccatg 11100 tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag tgcagttggc cataacggac 11160 cagttaacgg tctggtgacc cggctgcgag agctcggtgt acctgagacg cgagtaagcc 11220 ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt actggtatcc caccaaaaag 11280 tgcggcggcg gctggcggta gaggggccag cgtagggtgg ccggggctcc gggggcgaga 11340 tcttccaaca taaggcgatg atatccgtag atgtacctgg acatccaggt gatgccggcg 11400 gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc agatgttgcg cagcggcaaa 11460 aagtgctcca tggtcgggac gctctggccg gtcaggcgcg cgcaatcgtt gacgctctag 11520 accgtgcaaa aggagagcct gtaagcgggc actcttccgt ggtctggtgg ataaattcgc 11580 aagggtatca tggcggacga ccggggttcg agccccgtat ccggccgtcc gccgtgatcc 11640 atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg tcagacaacg ggggagtgct 11700 ccttttggct tccttccagg cgcggcggct gctgcgctag cttttttggc cactggccgc 11760 gcgcagcgta agcggttagg ctggaaagcg aaagcattaa gtggctcgct ccctgtagcc 11820 ggagggttat tttccaaggg ttgagtcgcg ggacccccgg ttcgagtctc ggaccggccg 11880 gactgcggcg aacgggggtt tgcctccccg tcatgcaaga ccccgcttgc aaattcctcc 11940 ggaaacaggg acgagcccct tttttgcttt tcccagatgc atccggtgct gcggcagatg 12000 cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc agacatgcag ggcaccctcc 12060 cctcctccta ccgcgtcagg aggggcgaca tccgcggttg acgcggcagc agatggtgat 12120 tacgaacccc cgcggcgccg ggcccggcac tacctggact tggaggaggg cgagggcctg 12180 gcgcggctag gagcgccctc tcctgagcgg cacccaaggg tgcagctgaa gcgtgatacg 12240 cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc gcgagggaga ggagcccgag 12300 gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc ggcatggcct gaatcgcgag 12360 cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa ccgggattag tcccgcgcgc 12420 gcacacgtgg cggccgccga cctggtaacc gcatacgagc agacggtgaa ccaggagatt 12480 aactttcaaa aaagctttaa caaccacgtg cgtacgcttg tggcgcgcga ggaggtggct 12540 ataggactga tgcatctgtg ggactttgta agcgcgctgg agcaaaaccc aaatagcaag 12600 ccgctcatgg cgcagctgtt ccttatagtg cagcacagca gggacaacga ggcattcagg 12660 gatgcgctgc taaacatagt agagcccgag ggccgctggc tgctcgattt gataaacatc 12720 ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg ctgacaaggt ggccgccatc 12780 aactattcca tgcttagcct gggcaagttt tacgcccgca agatatacca taccccttac 12840 gttcccatag acaaggaggt aaagatcgag gggttctaca tgcgcatggc gctgaaggtg 12900 cttaccttga gcgacgacct gggcgtttat cgcaacgagc gcatccacaa ggccgtgagc 12960 gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc acagcctgca aagggccctg 13020 gctggcacgg gcagcggcga tagagaggcc gagtcctact ttgacgcggg cgctgacctg 13080 cgctgggccc caagccgacg cgccctggag gcagctgggg ccggacctgg gctggcggtg 13140 gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat atgacgagga cgatgagtac 13200 gagccagagg acggcgagta ctaagcggtg atgtttctga tcagatgatg caagacgcaa 13260 cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc cggccttaac tccacggacg 13320 actggcgcca ggtcatggac cgcatcatgt cgctgactgc gcgcaatcct gacgcgttcc 13380 ggcagcagcc gcaggccaac cggctctccg caattctgga agcggtggtc ccggcgcgcg 13440 caaaccccac gcacgagaag gtgctggcga tcgtaaacgc gctggccgaa aacagggcca 13500 tccggcccga cgaggccggc ctggtctacg acgcgctgct tcagcgcgtg gctcgttaca 13560 acagcggcaa cgtgcagacc aacctggacc ggctggtggg ggatgtgcgc gaggccgtgg 13620 cgcagcgtga gcgcgcgcag cagcagggca acctgggctc catggttgca ctaaacgcct 13680 tcctgagtac acagcccgcc aacgtgccgc ggggacagga ggactacacc aactttgtga 13740 gcgcactgcg gctaatggtg actgagacac cgcaaagtga ggtgtaccag tctgggccag 13800 actatttttt ccagaccagt agacaaggcc tgcagaccgt aaacctgagc caggctttca 13860 aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg cgaccgcgcg accgtgtcta 13920 gcttgctgac gcccaactcg cgcctgttgc tgctgctaat agcgcccttc acggacagtg 13980 gcagcgtgtc ccgggacaca tacctaggtc acttgctgac actgtaccgc gaggccatag 14040 gtcaggcgca tgtggacgag catactttcc aggagattac aagtgtcagc cgcgcgctgg 14100 ggcaggagga cacgggcagc ctggaggcaa ccctaaacta cctgctgacc aaccggcggc 14160 agaagatccc ctcgttgcac agtttaaaca gcgaggagga gcgcattttg cgctacgtgc 14220 agcagagcgt gagccttaac ctgatgcgcg acggggtaac gcccagcgtg gcgctggaca 14280 tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa ccggccgttt atcaaccgcc 14340 taatggacta cttgcatcgc gcggccgccg tgaaccccga gtatttcacc aatgccatct 14400 tgaacccgca ctggctaccg ccccctggtt tctacaccgg gggattcgag gtgcccgagg 14460 gtaacgatgg attcctctgg gacgacatag acgacagcgt gttttccccg caaccgcaga 14520 ccctgctaga gttgcaacag cgcgagcagg cagaggcggc gctgcgaaag gaaagcttcc 14580 gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc gcggtcagat gctagtagcc 14640 catttccaag cttgataggg tctcttacca gcactcgcac cacccgcccg cgcctgctgg 14700 gcgaggagga gtacctaaac aactcgctgc tgcagccgca gcgcgaaaaa aacctgcctc 14760 cggcatttcc caacaacggg atagagagcc tagtggacaa gatgagtaga tggaagacgt 14820 acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc cacccgtcgt caaaggcacg 14880 accgtcagcg gggtctggtg tgggaggacg atgactcggc agacgacagc agcgtcctgg 14940 atttgggagg gagtggcaac ccgtttgcgc accttcgccc caggctgggg agaatgtttt 15000 aaaaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg gcaccgagcg 15060 ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg aaggtcctcc 15120 tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg gttctccctt 15180 cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta ccggggggag 15240 aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg tgtacctggt 15300 ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca gcaactttct 15360 gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac agaccatcaa 15420 tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata ccaacatgcc 15480 aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg tgtcgcgctt 15540 gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca cgctgcccga 15600 gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg tggagcacta 15660 cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa agtttgacac 15720 ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg gggtatatac 15780 aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg acttcaccca 15840 cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg agggctttag 15900 gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg tggacgccta 15960 ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg gcagcaacag 16020 cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc agccggtgga 16080 ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg aggagaagcg 16140 cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg aggtcgagaa 16200 gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac gcagttacaa 16260 cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg catacaacta 16320 cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg acgtaacctg 16380 cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg tgaccttccg 16440 ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc ccgtgcactc 16500 caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt ttacctctct 16560 gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc cagcccccac 16620 catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc taccgctgcg 16680 caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc gcacctgccc 16740 ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc gcactttttg 16800 agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc tgcgcttccc 16860 aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc gcgtgcgcgg 16920 gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca ccaccgtcga 16980 tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc cgccaccagt 17040 gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct atgctaaaat 17100 gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca ctgccgccca 17160 acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg cggccatgcg 17220 ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca ggcgacgagc 17280 ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg gcaacgtgta 17340 ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc ccccgcgcaa 17400 ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag cggcggcggc 17460 gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg tcatcgcgcc 17520 ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa agctaaagcg 17580 ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg aactgctgca 17640 cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac gtgttttgcg 17700 acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct acaagcgcgt 17760 gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc gcctcgggga 17820 gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg agggcaaccc 17880 aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg caccgtccga 17940 agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc agctgatggt 18000 acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac ctgggctgga 18060 gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg tgcagaccgt 18120 ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag agggcatgga 18180 gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg cggtcgctgc 18240 ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc gcgtttcagc 18300 cccccggcgc ccgcgccgtt cgaggaagta cggcgccgcc agcgcgctac tgcccgaata 18360 tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct accgccccag 18420 aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc gtcgccgtcg 18480 ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag gcaggaccct 18540 ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct ttgtggttct 18600 tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc gaggaagaat 18660 gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc gtgcgcacca 18720 ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc tccttattcc 18780 actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct tgcaggcgca 18840 gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt ctggactctc 18900 acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt gcgtctctgg 18960 ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc accagcaata 19020 tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat ttcggttcca 19080 ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg ctgagggata 19140 agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct ggcattagcg 19200 gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag cttgatcccc 19260 gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag gggcgtggcg 19320 aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac gagcctccct 19380 cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg cccatggcta 19440 ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc gccgacaccc 19500 agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct agccgcgcgt 19560 ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt ggcaactggc 19620 aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc cgacgatgct 19680 tctgaatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc gccagaggag 19740 ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga tgccgcagtg 19800 gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg ggctggtgca 19860 gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa accccacggt 19920 ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc ggttcatccc 19980 tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag ctgtgggtga 20040 taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc tggacagggg 20100 ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca agggtgcccc 20160 aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag aagaagagga 20220 cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc acgtatttgg 20280 gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag gtgtcgaagg 20340 tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag gagaatctca 20400 gtggtacgaa actgaaatta atcatgcagc tgggagagtc cttaaaaaga ctaccccaat 20460 gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc aaggcattct 20520 tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt tctcaactac 20580 tgaggcgacc gcaggcaatg gtgataactt gactcctaaa gtggtattgt acagtgaaga 20640 tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta aggaaggtaa 20700 ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca ttgcttttag 20760 ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg ttctggcggg 20820 ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag agctttcata 20880 ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt ggaatcaggc 20940 tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg aagatgaact 21000 tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta ccaaggtaaa 21060 acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt cagataaaaa 21120 tcaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca acctgtggag 21180 aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt acagtccttc 21240 caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc gagtggtggc 21300 tcccgggtta gtggactgct acattaacct tggagcacgc tggtcccttg actatatgga 21360 caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct caatgttgct 21420 gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct ttgccattaa 21480 aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga aggatgttaa 21540 catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca gcattaagtt 21600 tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg cctccacgct 21660 tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc tctccgccgc 21720 caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca tcccctcccg 21780 caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg aaaccccatc 21840 actgggctcg ggctacgacc cttattacac ctactctggc tctataccct acctagatgg 21900 aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact cttctgtcag 21960 ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc gctcagttga 22020 cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc tggtacaaat 22080 gctagctaac tacaacattg gctaccaggg cttctatatc ccagagagct acaaggaccg 22140 catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg atgatactaa 22200 atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg gatttgttgg 22260 ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc cctatccgct 22320 tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg atcgcaccct 22380 ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag acctgggcca 22440 aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg tggatcccat 22500 ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc gtgtgcaccg 22560 gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg ccggcaacgc 22620 cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc cagtgagcag 22680 gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg cacctatgac 22740 aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt caatacggcc 22800 ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca ctcaaaaaca 22860 tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt ttaccagttt 22920 gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg ctgtataacg 22980 ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg actattctgc 23040 tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca caaccccacc 23100 atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt acagcccacc 23160 ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc ctacttccgc 23220 agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa catgtaaaaa 23280 taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac tctcgggtga 23340 ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt ctgccgcgca 23400 tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct ccacttaaac 23460 tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct gcgcaccatc 23520 accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg gcctccgccc 23580 tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag cgccgggtgg 23640 tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc ctccgcgttg 23700 ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc gtgcccaggc 23760 tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt ctgggcgtta 23820 ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc ctttgcgcct 23880 tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca ggccgcgtcg 23940 tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc ccaccggttc 24000 ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt ttcgctcgtc 24060 acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag acacttaagc 24120 tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg ctcgtgatgc 24180 ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc catcatcgtc 24240 acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc gttcagccag 24300 gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa gttcgccttt 24360 agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat gcccttctcc 24420 cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact ttccgcttcg 24480 ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc gtcttcattc 24540 agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg tgggttgctg 24600 aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac gattacctct 24660 ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt gggcgcaatg 24720 gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac cagcgcgtct 24780 tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt ttttgggggc 24840 gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt tgggggacgt 24900 cgcgccgcac cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc ccgactggcc 24960 atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa ggacagccta 25020 accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc gcctaccacc 25080 ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca ggacccaggt 25140 tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa gcaagaccag 25200 gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca tggcgactac 25260 ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc cattatctgc 25320 gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag ccttgcctac 25380 gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg cacatgcgag 25440 cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct tgccacctat 25500 cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg cagccgagcg 25560 gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc gctcaacgaa 25620 gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa cgctctgcaa 25680 caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga gggtgacaac 25740 gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta cccggcactt 25800 aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg ccgtgcgcag 25860 cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc cgcagttggc 25920 gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga ggagcgacgc 25980 aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca gcggttcttt 26040 gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt tcgacagggc 26100 tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt ctcctacctt 26160 ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct caagggcgag 26220 gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac ctggcagacg 26280 gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct gcagaaactg 26340 ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt ggccgcgcac 26400 ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg tctgccagac 26460 ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg ctcaggaatc 26520 ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta ccgcgaatgc 26580 cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct tgcctaccac 26640 tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg tcgctgcaac 26700 ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga aagtcaaatt 26760 atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc tccggggttg 26820 aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc tgaggactac 26880 cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccaaatgc ggagcttacc 26940 gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa caaagcccgc 27000 caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc cggcgaggag 27060 ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc ccttgcttcc 27120 caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg aggaggaata 27180 ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga tggaagactg 27240 ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa caccgtcacc 27300 ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca gcatggctac 27360 aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc gtagatggga 27420 caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc aagagcaaca 27480 acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg cttgcttgca 27540 agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc acggcgtggc 27600 cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact gcaccggcgg 27660 cagcggcagc ggcagcaaca gcagcggcca cacagaagca aaggcgaccg gatagcaaga 27720 ctctgacaaa gcccaagaaa tccacagcgg cggcagcagc aggaggagga gcgctgcgtc 27780 tggcgcccaa cgaacccgta tcgacccgcg agcttagaaa caggattttt cccactctgt 27840 atgctatatt tcaacagagc aggggccaag aacaagagct gaaaataaaa aacaggtctc 27900 tgcgatccct cacccgcagc tgcctgtatc acaaaagcga agatcagctt cggcgcacgc 27960 tggaagacgc ggaggctctc ttcagtaaat actgcgcgct gactcttaag gactagtttc 28020 gcgccctttc tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca cacccggcgc 28080 cagcacctgt cgtcagcgcc atttcaactt tgtatacaaa agttgtgatg agcaaggaaa 28140 ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct ggagctgccc 28200 aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata tcccgggtca 28260 acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt accaccacac 28320 ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg 28380 ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg actaactcag 28440 gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag ggtataactc 28500 acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg 28560 gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca ttcacgcctc 28620 gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga ggcattggaa 28680 ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc tcgggacctc 28740 ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac tcggcggacg 28800 gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact 28860 gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt gaattgcccg 28920 aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga gagcttgccc 28980 gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac aggggaccct 29040 gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat ctttgttgcc 29100 atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc ctatcgccat 29160 cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt acctggtact 29220 tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt gagtctacga 29280 gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct tacctgccgg 29340 gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg taaaccagac 29400 tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc ttagaaaacc 29460 cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt caagcaactc 29520 tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc tctgtcttgt 29580 gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct gctgtgtgca 29640 catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat gattaggtac 29700 ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa ggtggatttt 29760 aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac cactcttata 29820 aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat tggcaagtat 29880 gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac agttttccag 29940 ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg cgacattacc 30000 atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga aaacactggc 30060 actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac cctactctat 30120 attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta atttactaag 30180 ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca aattcaaaaa 30240 gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct caataccatt 30300 cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg aagtcaggct 30360 tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt tccagtccaa 30420 ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc cgctaccgga 30480 cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg ggataacttg 30540 ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat gtggctcatc 30600 tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat tgtgctacac 30660 ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt ttctcttaca 30720 gtatgattaa atgagacatg attcctcgag tttttatatt actgaccctt gttgcgcttt 30780 tttgtgcgtg ctccacattg gctgcggttt ctcacatcga agtagactgc attccagcct 30840 tcacagtcta tttgctttac ggatttgtca ccctcacgct catctgcagc ctcatcactg 30900 tggtcatcgc ctttatccag tgcattgact gggtctgtgt gcgctttgca tatctcagac 30960 accatcccca gtacagggac aggactatag ctgagcttct tagaattctt taattatgaa 31020 atttactgtg acttttctgc tgattatttg caccctatct gcgttttgtt ccccgacctc 31080 caagcctcaa agacatatat catgcagatt cactcgtata tggaatattc caagttgcta 31140 caatgaaaaa agcgatcttt ccgaagcctg gttatatgca atcatctctg ttatggtgtt 31200 ctgcagtacc atcttagccc tagctatata tccctacctt gacattggct ggaacgcaat 31260 agatgccatg aaccacccaa ctttccccgc gcccgctatg cttccactgc aacaagttgt 31320 tgccggcggc tttgtcccag ccaatcagcc tcgcccacct tctcccaccc ccactgaaat 31380 cagctacttt aatctaacag gaggagatga ctgacaccct agatctagaa atggacggaa 31440 ttattacaga gcagcgcctg ctagaaagac gcagggcagc ggccgagcaa cagcgcatga 31500 atcaagagct ccaagacatg gttaacttgc accagtgcaa aaggggtatc ttttgtctgg 31560 taaagcaggc caaagtcacc tacgacagta ataccaccgg acaccgcctt agctacaagt 31620 tgccaaccaa gcgtcagaaa ttggtggtca tggtgggaga aaagcccatt accataactc 31680 agcactcggt agaaaccgaa ggctgcattc actcaccttg tcaaggacct gaggatctct 31740 gcacccttat taagaccctg tgcggtctca aagatcttat tccctttaac taataaaaaa 31800 aaataataaa gcatcactta cttaaaatca gttagcaaat ttctgtccag tttattcagc 31860 agcacctcct tgccctcctc ccagctctgg tattgcagct tcctcctggc tgcaaacttt 31920 ctccacaatc taaatggaat gtcagtttcc tcctgttcct gtccatccgc acccactatc 31980 ttcatgttgt tgcagatgaa gcgcgcaaga ccgtctgaag ataccttcaa ccccgtgtat 32040 ccatatgaca cggaaaccgg tcctccaact gtgccttttc ttactcctcc ctttgtatcc 32100 cccaatgggt ttcaagagag tccccctggg gtactctctt tgcgcctatc cgaacctcta 32160 gttacctcca atggcatgct tgcgctcaaa atgggcaacg gcctctctct ggacgaggcc 32220 ggcaacctta cctcccaaaa tgtaaccact gtgagcccac ctctcaaaaa aaccaagtca 32280 aacataaacc tggaaatatc tgcacccctc acagttacct cagaagccct aactgtggct 32340 gccgccgcac ctctaatggt cgcgggcaac acactcacca tgcaatcaca ggccccgcta 32400 accgtgcacg actccaaact tagcattgcc acccaaggac ccctcacagt gtcagaagga 32460 aagctagccc tgcaaacatc aggccccctc accaccaccg atagcagtac ccttactatc 32520 actgcctcac cccctctaac tactgccact ggtagcttgg gcattgactt gaaagagccc 32580 atttatacac aaaatggaaa actaggacta aagtacgggg ctcctttgca tgtaacagac 32640 gacctaaaca ctttgaccgt agcaactggt ccaggtgtga ctattaataa tacttccttg 32700 caaactaaag ttactggagc cttgggtttt gattcacaag gcaatatgca acttaatgta 32760 gcaggaggac taaggattga ttctcaaaac agacgcctta tacttgatgt tagttatccg 32820 tttgatgctc aaaaccaact aaatctaaga ctaggacagg gccctctttt tataaactca 32880 gcccacaact tggatattaa ctacaacaaa ggcctttact tgtttacagc ttcaaacaat 32940 tccaaaaagc ttgaggttaa cctaagcact gccaaggggt tgatgtttga cgctacagcc 33000 atagccatta atgcaggaga tgggcttgaa tttggttcac ctaatgcacc aaacacaaat 33060 cccctcaaaa caaaaattgg ccatggccta gaatttgatt caaacaaggc tatggttcct 33120 aaactaggaa ctggccttag ttttgacagc acaggtgcca ttacagtagg aaacaaaaat 33180 aatgataagc taactttgtg gaccacacca gctccatctc ctaactgtag actaaatgca 33240 gagaaagatg ctaaactcac tttggtctta acaaaatgtg gcagtcaaat acttgctaca 33300 gtttcagttt tggctgttaa aggcagtttg gctccaatat ctggaacagt tcaaagtgct 33360 catcttatta taagatttga cgaaaatgga gtgctactaa acaattcctt cctggaccca 33420 gaatattgga actttagaaa tggagatctt actgaaggca cagcctatac aaacgctgtt 33480 ggatttatgc ctaacctatc agcttatcca aaatctcacg gtaaaactgc caaaagtaac 33540 attgtcagtc aagtttactt aaacggagac aaaactaaac ctgtaacact aaccattaca 33600 ctaaacggta cacaggaaac aggagacaca actccaagtg catactctat gtcattttca 33660 tgggactggt ctggccacaa ctacattaat gaaatatttg ccacatcctc ttacactttt 33720 tcatacattg cccaagaata aagaatcgtt tgtgttatgt ttcaacgtgt ttatttttca 33780 attgcagaaa atttcaagtc atttttcatt cagtagtata gccccaccac cacatagctt 33840 atacagatca ccgtacctca actttgtata ataaagttgt aatcaaactc acagaaccct 33900 agtattcaac ctgccacctc cctcccaaca cacagagtac acagtccttt ctccccggct 33960 ggccttaaaa agcatcatat catgggtaac agacatattc ttaggtgtta tattccacac 34020 ggtttcctgt cgagccaaac gctcatcagt gatattaata aactccccgg gcagctcact 34080 taagttcatg tcgctgtcca gctgctgagc cacaggctgc tgtccaactt gcggttgctt 34140 aacgggcggc gaaggagaag tccacgccta catgggggta gagtcataat cgtgcatcag 34200 gatagggcgg tggtgctgca gcagcgcgcg aataaactgc tgccgccgcc gctccgtcct 34260 gcaggaatac aacatggcag tggtctcctc agcgatgatt cgcaccgccc gcagcataag 34320 gcgccttgtc ctccgggcac agcagcgcac cctgatctca cttaaatcag cacagtaact 34380 gcagcacagc accacaatat tgttcaaaat cccacagtgc aaggcgctgt atccaaagct 34440 catggcgggg accacagaac ccacgtggcc atcataccac aagcgcaggt agattaagtg 34500 gcgacccctc ataaacacgc tggacataaa cattacctct tttggcatgt tgtaattcac 34560 cacctcccgg taccatataa acctctgatt aaacatggcg ccatccacca ccatcctaaa 34620 ccagctggcc aaaacctgcc cgccggctat acactgcagg gaaccgggac tggaacaatg 34680 acagtggaga gcccaggact cgtaaccatg gatcatcatg ctcgtcatga tatcaatgtt 34740 ggcacaacac aggcacacgt gcatacactt cctcaggatt acaagctcct cccgcgttag 34800 aaccatatcc cagggaacaa cccattcctg aatcagcgta aatcccacac tgcagggaag 34860 acctcgcacg taactcacgt tgtgcattgt caaagtgtta cattcgggca gcagcggatg 34920 atcctccagt atggtagcgc gggtttctgt ctcaaaagga ggtagacgat ccctactgta 34980 cggagtgcgc cgagacaacc gagatcgtgt tggtcgtagt gtcatgccaa atggaacgcc 35040 ggacgtagtc atatttcctg aagcaaaacc aggtgcgggc gtgacaaaca gatctgcgtc 35100 tccggtctcg ccgcttagat cgctctgtgt agtagttgta gtatatccac tctctcaaag 35160 catccaggcg ccccctggct tcgggttcta tgtaaactcc ttcatgcgcc gctgccctga 35220 taacatccac caccgcagaa taagccacac ccagccaacc tacacattcg ttctgcgagt 35280 cacacacggg aggagcggga agagctggaa gaaccatgtt ttttttttta ttccaaaaga 35340 ttatccaaaa cctcaaaatg aagatctatt aagtgaacgc gctcccctcc ggtggcgtgg 35400 tcaaactcta cagccaaaga acagataatg gcatttgtaa gatgttgcac aatggcttcc 35460 aaaaggcaaa cggccctcac gtccaagtgg acgtaaaggc taaacccttc agggtgaatc 35520 tcctctataa acattccagc accttcaacc atgcccaaat aattctcatc tcgccacctt 35580 ctcaatatat ctctaagcaa atcccgaata ttaagtccgg ccattgtaaa aatctgctcc 35640 agagcgccct ccaccttcag cctcaagcag cgaatcatga ttgcaaaaat tcaggttcct 35700 cacagacctg tataagattc aaaagcggaa cattaacaaa aataccgcga tcccgtaggt 35760 cccttcgcag ggccagctga acataatcgt gcaggtctgc acggaccagc gcggccactt 35820 ccccgccagg aaccatgaca aaagaaccca cactgattat gacacgcata ctcggagcta 35880 tgctaaccag cgtagccccg atgtaagctt gttgcatggg cggcgatata aaatgcaagg 35940 tgctgctcaa aaaatcaggc aaagcctcgc gcaaaaaaga aagcacatcg tagtcatgct 36000 catgcagata aaggcaggta agctccggaa ccaccacaga aaaagacacc atttttctct 36060 caaacatgtc tgcgggtttc tgcataaaca caaaataaaa taacaaaaaa acatttaaac 36120 attagaagcc tgtcttacaa caggaaaaac aacccttata agcataagac ggactacggc 36180 catgccggcg tgaccgtaaa aaaactggtc accgtgatta aaaagcacca ccgacagctc 36240 ctcggtcatg tccggagtca taatgtaaga ctcggtaaac acatcaggtt gattcacatc 36300 ggtcagtgct aaaaagcgac cgaaatagcc cgggggaata catacccgca ggcgtagaga 36360 caacattaca gcccccatag gaggtataac aaaattaata ggagagaaaa acacataaac 36420 acctgaaaaa ccctcctgcc taggcaaaat agcaccctcc cgctccagaa caacatacag 36480 cgcttccaca gcggcagcca taacagtcag ccttaccagt aaaaaagaaa acctattaaa 36540 aaaacaccac tcgacacggc accagctcaa tcagtcacag tgtaaaaaag ggccaagtgc 36600 agagcgagta tatataggac taaaaaatga cgtaacggtt aaagtccaca aaaaacaccc 36660 agaaaaccgc acgcgaacct acgcccagaa acgaaagcca aaaaacccac aacttcctca 36720 aatcgtcact tccgttttcc cacgttacgt cacttcccat tttaagaaaa ctacaattcc 36780 caacacatac aagttactcc gccctaaaac ctacgtcacc cgccccgttc ccacgccccg 36840 cgccacgtca caaactccac cccctcatta tcatattggc ttcaatccaa aataaggtat 36900 attattgatg atg 36913 <210> 30 <211> 35577 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO335) <400> 30 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagct aagtgtcttg ctgtctttat 4080 ttaggggttt tgcgcgcgcg gtaggcccgg gaccagcggt ctcggtcgtt gagggtcctg 4140 tgtatttttt ccaggacgtg gtaaaggtga ctctggatgt tcagatacat gggcataagc 4200 ccgtctctgg ggtggaggta gcaccactgc agagcttcat gctgcggggt ggtgttgtag 4260 atgatccagt cgtagcagga gcgctgggcg tggtgcctaa aaatgtcttt cagtagcaag 4320 ctgattgcca ggggcaggcc cttggtgtaa gtgtttacaa agcggttaag ctgggatggg 4380 tgcatacgtg gggatatgag atgcatcttg gactgtattt ttaggttggc tatgttccca 4440 gccatatccc tccggggatt catgttgtgc agaaccacca gcacagtgta tccggtgcac 4500 ttgggaaatt tgtcatgtag cttagaagga aatgcgtgga agaacttgga gacgcccttg 4560 tgacctccaa gattttccat gcattcgtcc ataatgatgg caatgggccc acgggcggcg 4620 gcctgggcga agatatttct gggatcacta acgtcatagt tgtgttccag gatgagatcg 4680 tcataggcca tttttacaaa gcgcgggcgg agggtgccag actgcggtat aatggttcca 4740 tccggcccag gggcgtagtt accctcacag atttgcattt cccacgcttt gagttcagat 4800 ggggggatca tgtctacctg cggggcgatg aagaaaacgg tttccggggt aggggagatc 4860 agctgggaag aaagcaggtt cctgagcagc tgcgacttac cgcagccggt gggcccgtaa 4920 atcacaccta ttaccgggtg caactggtag ttaagagagc tgcagctgcc gtcatccctg 4980 agcagggggg ccacttcgtt aagcatgtcc ctgactcgca tgttttccct gaccaaatcc 5040 gccagaaggc gctcgccgcc cagcgatagc agttcttgca aggaagcaaa gtttttcaac 5100 ggtttgagac cgtccgccgt aggcatgctt ttgagcgttt gaccaagcag ttccaggcgg 5160 tcccacagct cggtcacctg ctctacggca tctcgatcca gcatatctcc tcgtttcgcg 5220 ggttggggcg gctttcgctg tacggcagta gtcggtgctc gtccagacgg gccagggtca 5280 tgtctttcca cgggcgcagg gtcctcgtca gcgtagtctg ggtcacggtg aaggggtgcg 5340 ctccgggctg cgcgctggcc agggtgcgct tgaggctggt cctgctggtg ctgaagcgct 5400 gccggtcttc gccctgcgcg tcggccaggt agcatttgac catggtgtca tagtccagcc 5460 cctccgcggc gtggcccttg gcgcgcagct tgcccttgga ggaggcgccg cacgaggggc 5520 agtgcagact tttgagggcg tagagcttgg gcgcgagaaa taccgattcc ggggagtagg 5580 catccgcgcc gcaggccccg cagacggtct cgcattccac gagccaggtg agctctggcc 5640 gttcggggtc aaaaaccagg tttcccccat gctttttgat gcgtttctta cctctggttt 5700 ccatgagccg gtgtccacgc tcggtgacga aaaggctgtc cgtgtccccg tatacagact 5760 tgagaggcct gtcctcgagc ggtgttccgc ggtcctcctc gtatagaaac tcggaccact 5820 ctgagacaaa ggctcgcgtc caggccagca cgaaggaggc taagtgggag gggtagcggt 5880 cgttgtccac tagggggtcc actcgctcca gggtgtgaag acacatgtcg ccctcttcgg 5940 catcaaggaa ggtgattggt ttgtaggtgt aggccacgtg accgggtgtt cctgaagggg 6000 ggctataaaa gggggtgggg gcgcgttcgt cctcactctc ttccgcatcg ctgtctgcga 6060 gggccagctg ttggggtgag tactccctct gaaaagcggg catgacttct gcgctaagat 6120 tgtcagtttc caaaaacgag gaggatttga tattcacctg gcccgcggtg atgcctttga 6180 gggtggccgc atccatctgg tcagaaaaga caatcttttt gttgtcaagc ttggtggcaa 6240 acgacccgta gagggcgttg gacagcaact tggcgatgga gcgcagggtt tggtttttgt 6300 cgcgatcggc gcgctccttg gccgcgatgt ttagctgcac gtattcgcgc gcaacgcacc 6360 gccattcggg aaagacggtg gtgcgctcgt cgggcaccag gtgcacgcgc caaccgcggt 6420 tgtgcagggt gacaaggtca acgctggtgg ctacctctcc gcgtaggcgc tcgttggtcc 6480 agcagaggcg gccgcccttg cgcgagcaga atggcggtag ggggtctagc tgcgtctcgt 6540 ccggggggtc tgcgtccacg gtaaagaccc cgggcagcag gcgcgcgtcg aagtagtcta 6600 tcttgcatcc ttgcaagtct agcgcctgct gccatgcgcg ggcggcaagc gcgcgctcgt 6660 atgggttgag tgggggaccc catggcatgg ggtgggtgag cgcggaggcg tacatgccgc 6720 aaatgtcgta aacgtagagg ggctctctga gtattccaag atatgtaggg tagcatcttc 6780 caccgcggat gctggcgcgc acgtaatcgt atagttcgtg cgagggagcg aggaggtcgg 6840 gaccgaggtt gctacgggcg ggctgctctg ctcggaagac tatctgcctg aagatggcat 6900 gtgagttgga tgatatggtt ggacgctgga agacgttgaa gctggcgtct gtgagaccta 6960 ccgcgtcacg cacgaaggag gcgtaggagt cgcgcagctt gttgaccagc tcggcggtga 7020 cctgcacgtc tagggcgcag tagtccaggg tttccttgat gatgtcatac ttatcctgtc 7080 cctttttttt ccacagctcg cggttgagga caaactcttc gcggtctttc cagtactctt 7140 ggatcggaaa cccgtcggcc tccgaacggt aagagcctag catgtagaac tggttgacgg 7200 cctggtaggc gcagcatccc ttttctacgg gtagcgcgta tgcctgcgcg gccttccgga 7260 gcgaggtgtg ggtgagcgca aaggtgtccc tgaccatgac tttgaggtac tggtatttga 7320 agtcagtgtc gtcgcatccg ccctgctccc agagcaaaaa gtccgtgcgc tttttggaac 7380 gcggatttgg cagggcgaag gtgacatcgt tgaagagtat ctttcccgcg cgaggcataa 7440 agttgcgtgt gatgcggaag ggtcccggca cctcggaacg gttgttaatt acctgggcgg 7500 cgagcacgat ctcgtcaaag ccgttgatgt tgtggcccac aatgtaaagt tccaagaagc 7560 gcgggatgcc cttgatggaa ggcaattttt taagttcctc gtaggtgagc tcttcagggg 7620 agctgagccc gtgctctgaa agggcccagt ctgcaagatg agggttggaa gcgacgaatg 7680 agctccacag gtcacgggcc attagcattt gcaggtggtc gcgaaaggtc ctaaactggc 7740 gacctatggc cattttttct ggggtgatgc agtagaaggt aagcgggtct tgttcccagc 7800 ggtcccatcc aaggttcgcg gctaggtctc gcgcggcagt cactagaggc tcatctccgc 7860 cgaacttcat gaccagcatg aagggcacga gctgcttccc aaaggccccc atccaagtat 7920 aggtctctac atcgtaggtg acaaagagac gctcggtgcg aggatgcgag ccgatcggga 7980 agaactggat ctcccgccac caattggagg agtggctatt gatgtggtga aagtagaagt 8040 ccctgcgacg ggccgaacac tcgtgctggc ttttgtaaaa acgtgcgcag tactggcagc 8100 ggtgcacggg ctgtacatcc tgcacgaggt tgacctgacg accgcgcaca aggaagcaga 8160 gtgggaattt gagcccctcg cctggcgggt ttggctggtg gtcttctact tcggctgctt 8220 gtccttgacc gtctggctgc tcgaggggag ttacggtgga tcggaccacc acgccgcgcg 8280 agcccaaagt ccagatgtcc gcgcgcggcg gtcggagctt gatgacaaca tcgcgcagat 8340 gggagctgtc catggtctgg agctcccgcg gcgtcaggtc aggcgggagc tcctgcaggt 8400 ttacctcgca tagacgggtc agggcgcggg ctagatccag gtgataccta atttccaggg 8460 gctggttggt ggcggcgtcg atggcttgca agaggccgca tccccgcggc gcgactacgg 8520 taccgcgcgg cgggcggtgg gccgcggggg tgtccttgga tgatgcatct aaaagcggtg 8580 acgcgggcga gcccccggag gtaggggggg ctccggaccc gccgggagag ggggcagggg 8640 cacgtcggcg ccgcgcgcgg gcaggagctg gtgctgcgcg cgtaggttgc tggcgaacgc 8700 gacgacgcgg cggttgatct cctgaatctg gcgcctctgc gtgaagacga cgggcccggt 8760 gagcttgagc ctgaaagaga gttcgacaga atcaatttcg gtgtcgttga cggcggcctg 8820 gcgcaaaatc tcctgcacgt ctcctgagtt gtcttgatag gcgatctcgg ccatgaactg 8880 ctcgatctct tcctcctgga gatctccgcg tccggctcgc tccacggtgg cggcgaggtc 8940 gttggaaatg cgggccatga gctgcgagaa ggcgttgagg cctccctcgt tccagacgcg 9000 gctgtagacc acgccccctt cggcatcgcg ggcgcgcatg accacctgcg cgagattgag 9060 ctccacgtgc cgggcgaaga cggcgtagtt tcgcaggcgc tgaaagaggt agttgagggt 9120 ggtggcggtg tgttctgcca cgaagaagta cataacccag cgtcgcaacg tggattcgtt 9180 gatatccccc aaggcctcaa ggcgctccat ggcctcgtag aagtccacgg cgaagttgaa 9240 aaactgggag ttgcgcgccg acacggttaa ctcctcctcc agaagacgga tgagctcggc 9300 gacagtgtcg cgcacctcgc gctcaaaggc tacaggggcc tcttcttctt cttcaatctc 9360 ctcttccata agggcctccc cttcttcttc ttctggcggc ggtgggggag gggggacacg 9420 gcggcgacga cggcgcaccg ggaggcggtc gacaaagcgc tcgatcatct ccccgcggcg 9480 acggcgcatg gtctcggtga cggcgcggcc gttctcgcgg gggcgcagtt ggaagacgcc 9540 gcccgtcatg tcccggttat gggttggcgg ggggctgcca tgcggcaggg atacggcgct 9600 aacgatgcat ctcaacaatt gttgtgtagg tactccgccg ccgagggacc tgagcgagtc 9660 cgcatcgacc ggatcggaaa acctctcgag aaaggcgtct aaccagtcac agtcgcaagg 9720 taggctgagc accgtggcgg gcggcagcgg gcggcggtcg gggttgtttc tggcggaggt 9780 gctgctgatg atgtaattaa agtaggcggt cttgagacgg cggatggtcg acagaagcac 9840 catgtccttg ggtccggcct gctgaatgcg caggcggtcg gccatgcccc aggcttcgtt 9900 ttgacatcgg cgcaggtctt tgtagtagtc ttgcatgagc ctttctaccg gcacttcttc 9960 ttctccttcc tcttgtcctg catctcttgc atctatcgct gcggcggcgg cggagtttgg 10020 ccgtaggtgg cgccctcttc ctcccatgcg tgtgaccccg aagcccctca tcggctgaag 10080 cagggctagg tcggcgacaa cgcgctcggc taatatggcc tgctgcacct gcgtgagggt 10140 agactggaag tcatccatgt ccacaaagcg gtggtatgcg cccgtgttga tggtgtaagt 10200 gcagttggcc ataacggacc agttaacggt ctggtgaccc ggctgcgaga gctcggtgta 10260 cctgagacgc gagtaagccc tcgagtcaaa tacgtagtcg ttgcaagtcc gcaccaggta 10320 ctggtatccc accaaaaagt gcggcggcgg ctggcggtag aggggccagc gtagggtggc 10380 cggggctccg ggggcgagat cttccaacat aaggcgatga tatccgtaga tgtacctgga 10440 catccaggtg atgccggcgg cggtggtgga ggcgcgcgga aagtcgcgga cgcggttcca 10500 gatgttgcgc agcggcaaaa agtgctccat ggtcgggacg ctctggccgg tcaggcgcgc 10560 gcaatcgttg acgctctaga ccgtgcaaaa ggagagcctg taagcgggca ctcttccgtg 10620 gtctggtgga taaattcgca agggtatcat ggcggacgac cggggttcga gccccgtatc 10680 cggccgtccg ccgtgatcca tgcggttacc gcccgcgtgt cgaacccagg tgtgcgacgt 10740 cagacaacgg gggagtgctc cttttggctt ccttccaggc gcggcggctg ctgcgctagc 10800 ttttttggcc actggccgcg cgcagcgtaa gcggttaggc tggaaagcga aagcattaag 10860 tggctcgctc cctgtagccg gagggttatt ttccaagggt tgagtcgcgg gacccccggt 10920 tcgagtctcg gaccggccgg actgcggcga acgggggttt gcctccccgt catgcaagac 10980 cccgcttgca aattcctccg gaaacaggga cgagcccctt ttttgctttt cccagatgca 11040 tccggtgctg cggcagatgc gcccccctcc tcagcagcgg caagagcaag agcagcggca 11100 gacatgcagg gcaccctccc ctcctcctac cgcgtcagga ggggcgacat ccgcggttga 11160 cgcggcagca gatggtgatt acgaaccccc gcggcgccgg gcccggcact acctggactt 11220 ggaggagggc gagggcctgg cgcggctagg agcgccctct cctgagcggt acccaagggt 11280 gcagctgaag cgtgatacgc gtgaggcgta cgtgccgcgg cagaacctgt ttcgcgaccg 11340 cgagggagag gagcccgagg agatgcggga tcgaaagttc cacgcagggc gcgagctgcg 11400 gcatggcctg aatcgcgagc ggttgctgcg cgaggaggac tttgagcccg acgcgcgaac 11460 cgggattagt cccgcgcgcg cacacgtggc ggccgccgac ctggtaaccg catacgagca 11520 gacggtgaac caggagatta actttcaaaa aagctttaac aaccacgtgc gtacgcttgt 11580 ggcgcgcgag gaggtggcta taggactgat gcatctgtgg gactttgtaa gcgcgctgga 11640 gcaaaaccca aatagcaagc cgctcatggc gcagctgttc cttatagtgc agcacagcag 11700 ggacaacgag gcattcaggg atgcgctgct aaacatagta gagcccgagg gccgctggct 11760 gctcgatttg ataaacatcc tgcagagcat agtggtgcag gagcgcagct tgagcctggc 11820 tgacaaggtg gccgccatca actattccat gcttagcctg ggcaagtttt acgcccgcaa 11880 gatataccat accccttacg ttcccataga caaggaggta aagatcgagg ggttctacat 11940 gcgcatggcg ctgaaggtgc ttaccttgag cgacgacctg ggcgtttatc gcaacgagcg 12000 catccacaag gccgtgagcg tgagccggcg gcgcgagctc agcgaccgcg agctgatgca 12060 cagcctgcaa agggccctgg ctggcacggg cagcggcgat agagaggccg agtcctactt 12120 tgacgcgggc gctgacctgc gctgggcccc aagccgacgc gccctggagg cagctggggc 12180 cggacctggg ctggcggtgg cacccgcgcg cgctggcaac gtcggcggcg tggaggaata 12240 tgacgaggac gatgagtacg agccagagga cggcgagtac taagcggtga tgtttctgat 12300 cagatgatgc aagacgcaac ggacccggcg gtgcgggcgg cgctgcagag ccagccgtcc 12360 ggccttaact ccacggacga ctggcgccag gtcatggacc gcatcatgtc gctgactgcg 12420 cgcaatcctg acgcgttccg gcagcagccg caggccaacc ggctctccgc aattctggaa 12480 gcggtggtcc cggcgcgcgc aaaccccacg cacgagaagg tgctggcgat cgtaaacgcg 12540 ctggccgaaa acagggccat ccggcccgac gaggccggcc tggtctacga cgcgctgctt 12600 cagcgcgtgg ctcgttacaa cagcggcaac gtgcagacca acctggaccg gctggtgggg 12660 gatgtgcgcg aggccgtggc gcagcgtgag cgcgcgcagc agcagggcaa cctgggctcc 12720 atggttgcac taaacgcctt cctgagtaca cagcccgcca acgtgccgcg gggacaggag 12780 gactacacca actttgtgag cgcactgcgg ctaatggtga ctgagacacc gcaaagtgag 12840 gtgtaccagt ctgggccaga ctattttttc cagaccagta gacaaggcct gcagaccgta 12900 aacctgagcc aggctttcaa aaacttgcag gggctgtggg gggtgcgggc tcccacaggc 12960 gaccgcgcga ccgtgtctag cttgctgacg cccaactcgc gcctgttgct gctgctaata 13020 gcgcccttca cggacagtgg cagcgtgtcc cgggacacat acctaggtca cttgctgaca 13080 ctgtaccgcg aggccatagg tcaggcgcat gtggacgagc atactttcca ggagattaca 13140 agtgtcagcc gcgcgctggg gcaggaggac acgggcagcc tggaggcaac cctaaactac 13200 ctgctgacca accggcggca gaagatcccc tcgttgcaca gtttaaacag cgaggaggag 13260 cgcattttgc gctacgtgca gcagagcgtg agccttaacc tgatgcgcga cggggtaacg 13320 cccagcgtgg cgctggacat gaccgcgcgc aacatggaac cgggcatgta tgcctcaaac 13380 cggccgttta tcaaccgcct aatggactac ttgcatcgcg cggccgccgt gaaccccgag 13440 tatttcacca atgccatctt gaacccgcac tggctaccgc cccctggttt ctacaccggg 13500 ggattcgagg tgcccgaggg taacgatgga ttcctctggg acgacataga cgacagcgtg 13560 ttttccccgc aaccgcagac cctgctagag ttgcaacagc gcgagcaggc agaggcggcg 13620 ctgcgaaagg aaagcttccg caggccaagc agcttgtccg atctaggcgc tgcggccccg 13680 cggtcagatg ctagtagccc atttccaagc ttgatagggt ctcttaccag cactcgcacc 13740 acccgcccgc gcctgctggg cgaggaggag tacctaaaca actcgctgct gcagccgcag 13800 cgcgaaaaaa acctgcctcc ggcatttccc aacaacggga tagagagcct agtggacaag 13860 atgagtagat ggaagacgta cgcgcaggag cacagggacg tgccaggccc gcgcccgccc 13920 acccgtcgtc aaaggcacga ccgtcagcgg ggtctggtgt gggaggacga tgactcggca 13980 gacgacagca gcgtcctgga tttgggaggg agtggcaacc cgtttgcgca ccttcgcccc 14040 aggctgggga gaatgtttta aaaaaaaaaa agcatgatgc aaaataaaaa actcaccaag 14100 gccatggcac cgagcgttgg ttttcttgta ttccccttag tatgcggcgc gcggcgatgt 14160 atgaggaagg tcctcctccc tcctacgaga gtgtggtgag cgcggcgcca gtggcggcgg 14220 cgctgggttc tcccttcgat gctcccctgg acccgccgtt tgtgcctccg cggtacctgc 14280 ggcctaccgg ggggagaaac agcatccgtt actctgagtt ggcaccccta ttcgacacca 14340 cccgtgtgta cctggtggac aacaagtcaa cggatgtggc atccctgaac taccagaacg 14400 accacagcaa ctttctgacc acggtcattc aaaacaatga ctacagcccg ggggaggcaa 14460 gcacacagac catcaatctt gacgaccggt cgcactgggg cggcgacctg aaaaccatcc 14520 tgcataccaa catgccaaat gtgaacgagt tcatgtttac caataagttt aaggcgcggg 14580 tgatggtgtc gcgcttgcct actaaggaca atcaggtgga gctgaaatac gagtgggtgg 14640 agttcacgct gcccgagggc aactactccg agaccatgac catagacctt atgaacaacg 14700 cgatcgtgga gcactacttg aaagtgggca gacagaacgg ggttctggaa agcgacatcg 14760 gggtaaagtt tgacacccgc aacttcagac tggggtttga ccccgtcact ggtcttgtca 14820 tgcctggggt atatacaaac gaagccttcc atccagacat cattttgctg ccaggatgcg 14880 gggtggactt cacccacagc cgcctgagca acttgttggg catccgcaag cggcaaccct 14940 tccaggaggg ctttaggatc acctacgatg atctggaggg tggtaacatt cccgcactgt 15000 tggatgtgga cgcctaccag gcgagcttga aagatgacac cgaacagggc gggggtggcg 15060 caggcggcag caacagcagt ggcagcggcg cggaagagaa ctccaacgcg gcagccgcgg 15120 caatgcagcc ggtggaggac atgaacgatc atgccattcg cggcgacacc tttgccacac 15180 gggctgagga gaagcgcgct gaggccgaag cagcggccga agctgccgcc cccgctgcgc 15240 aacccgaggt cgagaagcct cagaagaaac cggtgatcaa acccctgaca gaggacagca 15300 agaaacgcag ttacaaccta ataagcaatg acagcacctt cacccagtac cgcagctggt 15360 accttgcata caactacggc gaccctcaga ccggaatccg ctcatggacc ctgctttgca 15420 ctcctgacgt aacctgcggc tcggagcagg tctactggtc gttgccagac atgatgcaag 15480 accccgtgac cttccgctcc acgcgccaga tcagcaactt tccggtggtg ggcgccgagc 15540 tgttgcccgt gcactccaag agcttctaca acgaccaggc cgtctactcc caactcatcc 15600 gccagtttac ctctctgacc cacgtgttca atcgctttcc cgagaaccag attttggcgc 15660 gcccgccagc ccccaccatc accaccgtca gtgaaaacgt tcctgctctc acagatcacg 15720 ggacgctacc gctgcgcaac agcatcggag gagtccagcg agtgaccatt actgacgcca 15780 gacgccgcac ctgcccctac gtttacaagg ccctgggcat agtctcgccg cgcgtcctat 15840 cgagccgcac tttttgagca agcatgtcca tccttatatc gcccagcaat aacacaggct 15900 ggggcctgcg cttcccaagc aagatgtttg gcggggccaa gaagcgctcc gaccaacacc 15960 cagtgcgcgt gcgcgggcac taccgcgcgc cctggggcgc gcacaaacgc ggccgcactg 16020 ggcgcaccac cgtcgatgac gccatcgacg cggtggtgga ggaggcgcgc aactacacgc 16080 ccacgccgcc accagtgtcc acagtggacg cggccattca gaccgtggtg cgcggagccc 16140 ggcgctatgc taaaatgaag agacggcgga ggcgcgtagc acgtcgccac cgccgccgac 16200 ccggcactgc cgcccaacgc gcggcggcgg ccctgcttaa ccgcgcacgt cgcaccggcc 16260 gacgggcggc catgcgggcc gctcgaaggc tggccgcggg tattgtcact gtgcccccca 16320 ggtccaggcg acgagcggcc gccgcagcag ccgcggccat tagtgctatg actcagggtc 16380 gcaggggcaa cgtgtattgg gtgcgcgact cggttagcgg cctgcgcgtg cccgtgcgca 16440 cccgcccccc gcgcaactag attgcaagaa aaaactactt agactcgtac tgttgtatgt 16500 atccagcggc ggcggcgcgc aacgaagcta tgtccaagcg caaaatcaaa gaagagatgc 16560 tccaggtcat cgcgccggag atctatggcc ccccgaagaa ggaagagcag gattacaagc 16620 cccgaaagct aaagcgggtc aaaaagaaaa agaaagatga tgatgatgaa cttgacgacg 16680 aggtggaact gctgcacgct accgcgccca ggcgacgggt acagtggaaa ggtcgacgcg 16740 taaaacgtgt tttgcgaccc ggcaccaccg tagtctttac gcccggtgag cgctccaccc 16800 gcacctacaa gcgcgtgtat gatgaggtgt acggcgacga ggacctgctt gagcaggcca 16860 acgagcgcct cggggagttt gcctacggaa agcggcataa ggacatgctg gcgttgccgc 16920 tggacgaggg caacccaaca cctagcctaa agcccgtaac actgcagcag gtgctgcccg 16980 cgcttgcacc gtccgaagaa aagcgcggcc taaagcgcga gtctggtgac ttggcaccca 17040 ccgtgcagct gatggtaccc aagcgccagc gactggaaga tgtcttggaa aaaatgaccg 17100 tggaacctgg gctggagccc gaggtccgcg tgcggccaat caagcaggtg gcgccgggac 17160 tgggcgtgca gaccgtggac gttcagatac ccactaccag tagcaccagt attgccaccg 17220 ccacagaggg catggagaca caaacgtccc cggttgcctc agcggtggcg gatgccgcgg 17280 tgcaggcggt cgctgcggcc gcgtccaaga cctctacgga ggtgcaaacg gacccgtgga 17340 tgtttcgcgt ttcagccccc cggcgcccgc gcggttcgag gaagtacggc gccgccagcg 17400 cgctactgcc cgaatatgcc ctacatcctt ccattgcgcc tacccccggc tatcgtggct 17460 acacctaccg ccccagaaga cgagcaacta cccgacgccg aaccaccact ggaacccgcc 17520 gccgccgtcg ccgtcgccag cccgtgctgg ccccgatttc cgtgcgcagg gtggctcgcg 17580 aaggaggcag gaccctggtg ctgccaacag cgcgctacca ccccagcatc gtttaaaagc 17640 cggtctttgt ggttcttgca gatatggccc tcacctgccg cctccgtttc ccggtgccgg 17700 gattccgagg aagaatgcac cgtaggaggg gcatggccgg ccacggcctg acgggcggca 17760 tgcgtcgtgc gcaccaccgg cggcggcgcg cgtcgcaccg tcgcatgcgc ggcggtatcc 17820 tgcccctcct tattccactg atcgccgcgg cgattggcgc cgtgcccgga attgcatccg 17880 tggccttgca ggcgcagaga cactgattaa aaacaagttg catgtggaaa aatcaaaata 17940 aaaagtctgg actctcacgc tcgcttggtc ctgtaactat tttgtagaat ggaagacatc 18000 aactttgcgt ctctggcccc gcgacacggc tcgcgcccgt tcatgggaaa ctggcaagat 18060 atcggcacca gcaatatgag cggtggcgcc ttcagctggg gctcgctgtg gagcggcatt 18120 aaaaatttcg gttccaccgt taagaactat ggcagcaagg cctggaacag cagcacaggc 18180 cagatgctga gggataagtt gaaagagcaa aatttccaac aaaaggtggt agatggcctg 18240 gcctctggca ttagcggggt ggtggacctg gccaaccagg cagtgcaaaa taagattaac 18300 agtaagcttg atccccgccc tcccgtagag gagcctccac cggccgtgga gacagtgtct 18360 ccagaggggc gtggcgaaaa gcgtccgcgc cccgacaggg aagaaactct ggtgacgcaa 18420 atagacgagc ctccctcgta cgaggaggca ctaaagcaag gcctgcccac cacccgtccc 18480 atcgcgccca tggctaccgg agtgctgggc cagcacacac ccgtaacgct ggacctgcct 18540 ccccccgccg acacccagca gaaacctgtg ctgccaggcc cgaccgccgt tgttgtaacc 18600 cgtcctagcc gcgcgtccct gcgccgcgcc gccagcggtc cgcgatcgtt gcggcccgta 18660 gccagtggca actggcaaag cacactgaac agcatcgtgg gtctgggggt gcaatccctg 18720 aagcgccgac gatgcttctg aatagctaac gtgtcgtatg tgtgtcatgt atgcgtccat 18780 gtcgccgcca gaggagctgc tgagccgccg cgcgcccgct ttccaagatg gctacccctt 18840 cgatgatgcc gcagtggtct tacatgcaca tctcgggcca ggacgcctcg gagtacctga 18900 gccccgggct ggtgcagttt gcccgcgcca ccgagacgta cttcagcctg aataacaagt 18960 ttagaaaccc cacggtggcg cctacgcacg acgtgaccac agaccggtcc cagcgtttga 19020 cgctgcggtt catccctgtg gaccgtgagg atactgcgta ctcgtacaag gcgcggttca 19080 ccctagctgt gggtgataac cgtgtgctgg acatggcttc cacgtacttt gacatccgcg 19140 gcgtgctgga caggggccct acttttaagc cctactctgg cactgcctac aacgccctgg 19200 ctcccaaggg tgccccaaat ccttgcgaat gggatgaagc tgctactgct cttgaaataa 19260 acctagaaga agaggacgat gacaacgaag acgaagtaga cgagcaagct gagcagcaaa 19320 aaactcacgt atttgggcag gcgccttatt ctggtataaa tattacaaag gagggtattc 19380 aaataggtgt cgaaggtcaa acacctaaat atgccgataa aacatttcaa cctgaacctc 19440 aaataggaga atctcagtgg tacgaaactg aaattaatca tgcagctggg agagtcctta 19500 aaaagactac cccaatgaaa ccatgttacg gttcatatgc aaaacccaca aatgaaaatg 19560 gagggcaagg cattcttgta aagcaacaaa atggaaagct agaaagtcaa gtggaaatgc 19620 aatttttctc aactactgag gcgaccgcag gcaatggtga taacttgact cctaaagtgg 19680 tattgtacag tgaagatgta gatatagaaa ccccagacac tcatatttct tacatgccca 19740 ctattaagga aggtaactca cgagaactaa tgggccaaca atctatgccc aacaggccta 19800 attacattgc ttttagggac aattttattg gtctaatgta ttacaacagc acgggtaata 19860 tgggtgttct ggcgggccaa gcatcgcagt tgaatgctgt tgtagatttg caagacagaa 19920 acacagagct ttcataccag cttttgcttg attccattgg tgatagaacc aggtactttt 19980 ctatgtggaa tcaggctgtt gacagctatg atccagatgt tagaattatt gaaaatcatg 20040 gaactgaaga tgaacttcca aattactgct ttccactggg aggtgtgatt aatacagaga 20100 ctcttaccaa ggtaaaacct aaaacaggtc aggaaaatgg atgggaaaaa gatgctacag 20160 aattttcaga taaaaatcaa ataagagttg gaaataattt tgccatggaa atcaatctaa 20220 atgccaacct gtggagaaat ttcctgtact ccaacatagc gctgtatttg cccgacaagc 20280 taaagtacag tccttccaac gtaaaaattt ctgataaccc aaacacctac gactacatga 20340 acaagcgagt ggtggctccc gggttagtgg actgctacat taaccttgga gcacgctggt 20400 cccttgacta tatggacaac gtcaacccat ttaaccacca ccgcaatgct ggcctgcgct 20460 accgctcaat gttgctgggc aatggtcgct atgtgccctt ccacatccag gtgcctcaga 20520 agttctttgc cattaaaaac ctccttctcc tgccgggctc atacacctac gagtggaact 20580 tcaggaagga tgttaacatg gttctgcaga gctccctagg aaatgaccta agggttgacg 20640 gagccagcat taagtttgat agcatttgcc tttacgccac cttcttcccc atggcccaca 20700 acaccgcctc cacgcttgag gccatgctta gaaacgacac caacgaccag tcctttaacg 20760 actatctctc cgccgccaac atgctctacc ctatacccgc caacgctacc aacgtgccca 20820 tatccatccc ctcccgcaac tgggcggctt tccgcggctg ggccttcacg cgccttaaga 20880 ctaaggaaac cccatcactg ggctcgggct acgaccctta ttacacctac tctggctcta 20940 taccctacct agatggaacc ttttacctca accacacctt taagaaggtg gccattacct 21000 ttgactcttc tgtcagctgg cctggcaatg accgcctgct tacccccaac gagtttgaaa 21060 ttaagcgctc agttgacggg gagggttaca acgttgccca gtgtaacatg accaaagact 21120 ggttcctggt acaaatgcta gctaactaca acattggcta ccagggcttc tatatcccag 21180 agagctacaa ggaccgcatg tactccttct ttagaaactt ccagcccatg agccgtcagg 21240 tggtggatga tactaaatac aaggactacc aacaggtggg catcctacac caacacaaca 21300 actctggatt tgttggctac cttgccccca ccatgcgcga aggacaggcc taccctgcta 21360 acttccccta tccgcttata ggcaagaccg cagttgacag cattacccag aaaaagtttc 21420 tttgcgatcg caccctttgg cgcatcccat tctccagtaa ctttatgtcc atgggcgcac 21480 tcacagacct gggccaaaac cttctctacg ccaactccgc ccacgcgcta gacatgactt 21540 ttgaggtgga tcccatggac gagcccaccc ttctttatgt tttgtttgaa gtctttgacg 21600 tggtccgtgt gcaccggccg caccgcggcg tcatcgaaac cgtgtacctg cgcacgccct 21660 tctcggccgg caacgccaca acataaagaa gcaagcaaca tcaacaacag ctgccgccat 21720 gggctccagt gagcaggaac tgaaagccat tgtcaaagat cttggttgtg ggccatattt 21780 tttgggcacc tatgacaagc gctttccagg ctttgtttct ccacacaagc tcgcctgcgc 21840 catagtcaat acggccggtc gcgagactgg gggcgtacac tggatggcct ttgcctggaa 21900 cccgcactca aaaacatgct acctctttga gccctttggc ttttctgacc agcgactcaa 21960 gcaggtttac cagtttgagt acgagtcact cctgcgccgt agcgccattg cttcttcccc 22020 cgaccgctgt ataacgctgg aaaagtccac ccaaagcgta caggggccca actcggccgc 22080 ctgtggacta ttctgctgca tgtttctcca cgcctttgcc aactggcccc aaactcccat 22140 ggatcacaac cccaccatga accttattac cggggtaccc aactccatgc tcaacagtcc 22200 ccaggtacag cccaccctgc gtcgcaacca ggaacagctc tacagcttcc tggagcgcca 22260 ctcgccctac ttccgcagcc acagtgcgca gattaggagc gccacttctt tttgtcactt 22320 gaaaaacatg taaaaataat gtactagaga cactttcaat aaaggcaaat gcttttattt 22380 gtacactctc gggtgattat ttacccccac ccttgccgtc tgcgccgttt aaaaatcaaa 22440 ggggttctgc cgcgcatcgc tatgcgccac tggcagggac acgttgcgat actggtgttt 22500 agtgctccac ttaaactcag gcacaaccat ccgcggcagc tcggtgaagt tttcactcca 22560 caggctgcgc accatcacca acgcgtttag caggtcgggc gccgatatct tgaagtcgca 22620 gttggggcct ccgccctgcg cgcgcgagtt gcgatacaca gggttgcagc actggaacac 22680 tatcagcgcc gggtggtgca cgctggccag cacgctcttg tcggagatca gatccgcgtc 22740 caggtcctcc gcgttgctca gggcgaacgg agtcaacttt ggtagctgcc ttcccaaaaa 22800 gggcgcgtgc ccaggctttg agttgcactc gcaccgtagt ggcatcaaaa ggtgaccgtg 22860 cccggtctgg gcgttaggat acagcgcctg cataaaagcc ttgatctgct taaaagccac 22920 ctgagccttt gcgccttcag agaagaacat gccgcaagac ttgccggaaa actgattggc 22980 cggacaggcc gcgtcgtgca cgcagcacct tgcgtcggtg ttggagatct gcaccacatt 23040 tcggccccac cggttcttca cgatcttggc cttgctagac tgctccttca gcgcgcgctg 23100 cccgttttcg ctcgtcacat ccatttcaat cacgtgctcc ttatttatca taatgcttcc 23160 gtgtagacac ttaagctcgc cttcgatctc agcgcagcgg tgcagccaca acgcgcagcc 23220 cgtgggctcg tgatgcttgt aggtcacctc tgcaaacgac tgcaggtacg cctgcaggaa 23280 tcgccccatc atcgtcacaa aggtcttgtt gctggtgaag gtcagctgca acccgcggtg 23340 ctcctcgttc agccaggtct tgcatacggc cgccagagct tccacttggt caggcagtag 23400 tttgaagttc gcctttagat cgttatccac gtggtacttg tccatcagcg cgcgcgcagc 23460 ctccatgccc ttctcccacg cagacacgat cggcacactc agcgggttca tcaccgtaat 23520 ttcactttcc gcttcgctgg gctcttcctc ttcctcttgc gtccgcatac cacgcgccac 23580 tgggtcgtct tcattcagcc gccgcactgt gcgcttacct cctttgccat gcttgattag 23640 caccggtggg ttgctgaaac ccaccatttg tagcgccaca tcttctcttt cttcctcgct 23700 gtccacgatt acctctggtg atggcgggcg ctcgggcttg ggagaagggc gcttcttttt 23760 cttcttgggc gcaatggcca aatccgccgc cgaggtcgat ggccgcgggc tgggtgtgcg 23820 cggcaccagc gcgtcttgtg atgagtcttc ctcgtcctcg gactcgatac gccgcctcat 23880 ccgctttttt gggggcgccc ggggaggcgg cggcgacggg gacggggacg acacgtcctc 23940 catggttggg ggacgtcgcg ccgcaccgcg tccgcgctcg ggggtggttt cgcgctgctc 24000 ctcttcccga ctggccattt ccttctccta taggcagaaa aagatcatgg agtcagtcga 24060 gaagaaggac agcctaaccg ccccctctga gttcgccacc accgcctcca ccgatgccgc 24120 caacgcgcct accaccttcc ccgtcgaggc acccccgctt gaggaggagg aagtgattat 24180 cgagcaggac ccaggttttg taagcgaaga cgacgaggac cgctcagtac caacagagga 24240 taaaaagcaa gaccaggaca acgcagaggc aaacgaggaa caagtcgggc ggggggacga 24300 aaggcatggc gactacctag atgtgggaga cgacgtgctg ttgaagcatc tgcagcgcca 24360 gtgcgccatt atctgcgacg cgttgcaaga gcgcagcgat gtgcccctcg ccatagcgga 24420 tgtcagcctt gcctacgaac gccacctatt ctcaccgcgc gtacccccca aacgccaaga 24480 aaacggcaca tgcgagccca acccgcgcct caacttctac cccgtatttg ccgtgccaga 24540 ggtgcttgcc acctatcaca tctttttcca aaactgcaag atacccctat cctgccgtgc 24600 caaccgcagc cgagcggaca agcagctggc cttgcggcag ggcgctgtca tacctgatat 24660 cgcctcgctc aacgaagtgc caaaaatctt tgagggtctt ggacgcgacg agaagcgcgc 24720 ggcaaacgct ctgcaacagg aaaacagcga aaatgaaagt cactctggag tgttggtgga 24780 actcgagggt gacaacgcgc gcctagccgt actaaaacgc agcatcgagg tcacccactt 24840 tgcctacccg gcacttaacc taccccccaa ggtcatgagc acagtcatga gtgagctgat 24900 cgtgcgccgt gcgcagcccc tggagaggga tgcaaatttg caagaacaaa cagaggaggg 24960 cctacccgca gttggcgacg agcagctagc gcgctggctt caaacgcgcg agcctgccga 25020 cttggaggag cgacgcaaac taatgatggc cgcagtgctc gttaccgtgg agcttgagtg 25080 catgcagcgg ttctttgctg acccggagat gcagcgcaag ctagaggaaa cattgcacta 25140 cacctttcga cagggctacg tacgccaggc ctgcaagatc tccaacgtgg agctctgcaa 25200 cctggtctcc taccttggaa ttttgcacga aaaccgcctt gggcaaaacg tgcttcattc 25260 cacgctcaag ggcgaggcgc gccgcgacta cgtccgcgac tgcgtttact tatttctatg 25320 ctacacctgg cagacggcca tgggcgtttg gcagcagtgc ttggaggagt gcaacctcaa 25380 ggagctgcag aaactgctaa agcaaaactt gaaggaccta tggacggcct tcaacgagcg 25440 ctccgtggcc gcgcacctgg cggacatcat tttccccgaa cgcctgctta aaaccctgca 25500 acagggtctg ccagacttca ccagtcaaag catgttgcag aactttagga actttatcct 25560 agagcgctca ggaatcttgc ccgccacctg ctgtgcactt cctagcgact ttgtgcccat 25620 taagtaccgc gaatgccctc cgccgctttg gggccactgc taccttctgc agctagccaa 25680 ctaccttgcc taccactctg acataatgga agacgtgagc ggtgacggtc tactggagtg 25740 tcactgtcgc tgcaacctat gcaccccgca ccgctccctg gtttgcaatt cgcagctgct 25800 taacgaaagt caaattatcg gtacctttga gctgcagggt ccctcgcctg acgaaaagtc 25860 cgcggctccg gggttgaaac tcactccggg gctgtggacg tcggcttacc ttcgcaaatt 25920 tgtacctgag gactaccacg cccacgagat taggttctac gaagaccaat cccgcccgcc 25980 aaatgcggag cttaccgcct gcgtcattac ccagggccac attcttggcc aattgcaagc 26040 catcaacaaa gcccgccaag agtttctgct acgaaaggga cggggggttt acttggaccc 26100 ccagtccggc gaggagctca acccaatccc cccgccgccg cagccctatc agcagcagcc 26160 gcgggccctt gcttcccagg atggcaccca aaaagaagct gcagctgccg ccgccaccca 26220 cggacgagga ggaatactgg gacagtcagg cagaggaggt tttggacgag gaggaggagg 26280 acatgatgga agactgggag agcctagacg aggaagcttc cgaggtcgaa gaggtgtcag 26340 acgaaacacc gtcaccctcg gtcgcattcc cctcgccggc gccccagaaa tcggcaaccg 26400 gttccagcat ggctacaacc tccgctcctc aggcgccgcc ggcactgccc gttcgccgac 26460 ccaaccgtag atgggacacc actggaacca gggccggtaa gtccaagcag ccgccgccgt 26520 tagcccaaga gcaacaacag cgccaaggct accgctcatg gcgcgggcac aagaacgcca 26580 tagttgcttg cttgcaagac tgtgggggca acatctcctt cgcccgccgc tttcttctct 26640 accatcacgg cgtggccttc ccccgtaaca tcctgcatta ctaccgtcat ctctacagcc 26700 catactgcac cggcggcagc ggcagcggca gcaacagcag cggccacaca gaagcaaagg 26760 cgaccggata gcaagactct gacaaagccc aagaaatcca cagcggcggc agcagcagga 26820 ggaggagcgc tgcgtctggc gcccaacgaa cccgtatcga cccgcgagct tagaaacagg 26880 atttttccca ctctgtatgc tatatttcaa cagagcaggg gccaagaaca agagctgaaa 26940 ataaaaaaca ggtctctgcg atccctcacc cgcagctgcc tgtatcacaa aagcgaagat 27000 cagcttcggc gcacgctgga agacgcggag gctctcttca gtaaatactg cgcgctgact 27060 cttaaggact agtttcgcgc cctttctcaa atttaagcgc gaaaactacg tcatctccag 27120 cggccacacc cggcgccagc acctgtcgtc agcgccattt atgagcaagg aaattcccac 27180 gccctacatg tggagttacc agccacaaat gggacttgcg gctggagctg cccaagacta 27240 ctcaacccga ataaactaca tgagcgcggg accccacatg atatcccggg tcaacggaat 27300 acgcgcccac cgaaaccgaa ttctcctgga acaggcggct attaccacca cacctcgtaa 27360 taaccttaat ccccgtagtt ggcccgctgc cctggtgtac caggaaagtc ccgctcccac 27420 cactgtggta cttcccagag acgcccaggc cgaagttcag atgactaact caggggcgca 27480 gcttgcgggc ggctttcgtc acagggtgcg gtcgcccggg cagggtataa ctcacctgac 27540 aatcagaggg cgaggtattc agctcaacga cgagtcggtg agctcctcgc ttggtctccg 27600 tccggacggg acatttcaga tcggcggcgc cggccgctct tcattcacgc ctcgtcaggc 27660 aatcctaact ctgcagacct cgtcctctga gccgcgctct ggaggcattg gaactctgca 27720 atttattgag gagtttgtgc catcggtcta ctttaacccc ttctcgggac ctcccggcca 27780 ctatccggat caatttattc ctaactttga cgcggtaaag gactcggcgg acggctacga 27840 ctgaatgtta agtggagagg cagagcaact gcgcctgaaa cacctggtcc actgtcgccg 27900 ccacaagtgc tttgcccgcg actccggtga gttttgctac tttgaattgc ccgaggatca 27960 tatcgagggc ccggcgcacg gcgtccggct taccgcccag ggagagcttg cccgtagcct 28020 gattcgggag tttacccagc gccccctgct agttgagcgg gacaggggac cctgtgttct 28080 cactgtgatt tgcaactgtc ctaaccctgg attacatcaa gatctttgtt gccatctctg 28140 tgctgagtat aataaataca gaaattaaaa tatactgggg ctcctatcgc catcctgtaa 28200 acgccaccgt cttcacccgc ccaagcaaac caaggcgaac cttacctggt acttttaaca 28260 tctctccctc tgtgatttac aacagtttca acccagacgg agtgagtcta cgagagaacc 28320 tctccgagct cagctactcc atcagaaaaa acaccaccct ccttacctgc cgggaacgta 28380 cgagtgcgtc accggccgct gcaccacacc taccgcctga ccgtaaacca gactttttcc 28440 ggacagacct caataactct gtttaccaga acaggaggtg agcttagaaa acccttaggg 28500 tattaggcca aaggcgcagc tactgtgggg tttatgaaca attcaagcaa ctctacgggc 28560 tattctaatt caggtttctc tagaatcggg gttggggtta ttctctgtct tgtgattctc 28620 tttattctta tactaacgct tctctgccta aggctcgccg cctgctgtgt gcacatttgc 28680 atttattgtc agctttttaa acgctggggt cgccacccaa gatgattagg tacataatcc 28740 taggtttact cacccttgcg tcagcccacg gtaccaccca aaaggtggat tttaaggagc 28800 cagcctgtaa tgttacattc gcagctgaag ctaatgagtg caccactctt ataaaatgca 28860 ccacagaaca tgaaaagctg cttattcgcc acaaaaacaa aattggcaag tatgctgttt 28920 atgctatttg gcagccaggt gacactacag agtataatgt tacagttttc cagggtaaaa 28980 gtcataaaac ttttatgtat acttttccat tttatgaaat gtgcgacatt accatgtaca 29040 tgagcaaaca gtataagttg tggcccccac aaaattgtgt ggaaaacact ggcactttct 29100 gctgcactgc tatgctaatt acagtgctcg ctttggtctg taccctactc tatattaaat 29160 acaaaagcag acgcagcttt attgaggaaa agaaaatgcc ttaatttact aagttacaaa 29220 gctaatgtca ccactaactg ctttactcgc tgcttgcaaa acaaattcaa aaagttagca 29280 ttataattag aataggattt aaaccccccg gtcatttcct gctcaatacc attcccctga 29340 acaattgact ctatgtggga tatgctccag cgctacaacc ttgaagtcag gcttcctgga 29400 tgtcagcatc tgactttggc cagcacctgt cccgcggatt tgttccagtc caactacagc 29460 gacccaccct aacagagatg accaacacaa ccaacgcggc cgccgctacc ggacttacat 29520 ctaccacaaa tacaccccaa gtttctgcct ttgtcaataa ctgggataac ttgggcatgt 29580 ggtggttctc catagcgctt atgtttgtat gccttattat tatgtggctc atctgctgcc 29640 taaagcgcaa acgcgcccga ccacccatct atagtcccat cattgtgcta cacccaaaca 29700 atgatggaat ccatagattg gacggactga aacacatgtt cttttctctt acagtatgat 29760 taaatgagac atggccgttc agctggtgga aagtggcggg ggttctgttc aggcgggcgg 29820 gtctctgagg cttacttgcg ccgcgagtgg tagaaccagt cggagctacg gaatggggtg 29880 gtttaggcaa gctcccggga aagaacgcga atttgtgagc ggcattagct ggcggggcga 29940 ttccactggg tacgcagact ctgtaaaggg aaggtttacc atcagccgcg ataacgcaaa 30000 gaacaccgtt gatctgcaga tgaatagctt gagaccggag gacaccgcca tctactactg 30060 tgcagctgcc gccggaagca catggtatgg gactctgtat gaatacgact actggggcca 30120 gggtacacaa gttaccgtaa gcagcggctc tgggtccggc tcgaccggag tgcaggtgga 30180 aaccatctcc ccaggagacg ggcgcacctt ccccaagcgc ggccagacct gcgtggtgca 30240 ctacaccggg atgcttgaag atggaaagaa atttgattcc tcccgggaca gaaacaagcc 30300 ctttaagttt atgctaggca agcaggaggt gatccgaggc tgggaagaag gggttgccca 30360 gatgagtgtg ggtcagagag ccaaactgac tatatctcca gattatgcct atggtgccac 30420 tgggcaccca ggcatcatcc caccacatgc cactctcgtc ttcgatgtgg agcttctaaa 30480 actgtaataa aaaaaaataa taaagcatca cttacttaaa atcagttagc aaatttctgt 30540 ccagtttatt cagcagcacc tccttgccct cctcccagct ctggtattgc agcttcctcc 30600 tggctgcaaa ctttctccac aatctaaatg gaatgtcagt ttcctcctgt tcctgtccat 30660 ccgcacccac tatcttcatg ttgttgcaga tgaagcgcgc aagaccgtct gaagatacct 30720 tcaaccccgt gtatccatat gacacggaaa ccggtcctcc aactgtgcct tttcttactc 30780 ctccctttgt atcccccaat gggtttcaag agagtccccc tggggtactc tctttgcgcc 30840 tatccgaacc tctagttacc tccaatggca tgcttgcgct caaaatgggc aacggcctct 30900 ctctggacga ggccggcaac cttacctccc aaaatgtaac cactgtgagc ccacctctca 30960 aaaaaaccaa gtcaaacata aacctggaaa tatctgcacc cctcacagtt acctcagaag 31020 ccctaactgt ggctgccgcc gcacctctaa tggtcgcggg caacacactc accatgcaat 31080 cacaggcccc gctaaccgtg cacgactcca aacttagcat tgccacccaa ggacccctca 31140 cagtgtcaga aggaaagcta gccctgcaaa catcaggccc cctcaccacc accgatagca 31200 gtacccttac tatcactgcc tcaccccctc taactactgc cactggtagc ttgggcattg 31260 acttgaaaga gcccatttat acacaaaatg gaaaactagg actaaagtac ggggctcctt 31320 tgcatgtaac agacgaccta aacactttga ccgtagcaac tggtccaggt gtgactatta 31380 ataatacttc cttgcaaact aaagttactg gagccttggg ttttgattca caaggcaata 31440 tgcaacttaa tgtagcagga ggactaagga ttgattctca aaacagacgc cttatacttg 31500 atgttagtta tccgtttgat gctcaaaacc aactaaatct aagactagga cagggccctc 31560 tttttataaa ctcagcccac aacttggata ttaactacaa caaaggcctt tacttgttta 31620 cagcttcaaa caattccaaa aagcttgagg ttaacctaag cactgccaag gggttgatgt 31680 ttgacgctac agccatagcc attaatgcag gagatgggct tgaatttggt tcacctaatg 31740 caccaaacac aaatcccctc aaaacaaaaa ttggccatgg cctagaattt gattcaaaca 31800 aggctatggt tcctaaacta ggaactggcc ttagttttga cagcacaggt gccattacag 31860 taggaaacaa aaataatgat aagctaactt tgtggaccac accagctcca tctcctaact 31920 gtagactaaa tgcagagaaa gatgctaaac tcactttggt cttaacaaaa tgtggcagtc 31980 aaatacttgc tacagtttca gttttggctg ttaaaggcag tttggctcca atatctggaa 32040 cagttcaaag tgctcatctt attataagat ttgacgaaaa tggagtgcta ctaaacaatt 32100 ccttcctgga cccagaatat tggaacttta gaaatggaga tcttactgaa ggcacagcct 32160 atacaaacgc tgttggattt atgcctaacc tatcagctta tccaaaatct cacggtaaaa 32220 ctgccaaaag taacattgtc agtcaagttt acttaaacgg agacaaaact aaacctgtaa 32280 cactaaccat tacactaaac ggtacacagg aaacaggaga cacaactgag atgtggcatg 32340 aaggcctaga agaggcctct cgcttgtact ttggggagag gaacgtcaaa ggcatgtttg 32400 aggtgctgga gcccctgcat gctatgatgg aacgcggtcc ccagaccctg aaggaaacgt 32460 cctttaatca ggcatatggt cgagatttaa tggaggcaca agaatggtgc cgaaagtaca 32520 tgaaatcagg gaacgtcaag gacctcctcc aagcctggga cctctactat cacgtgttca 32580 gacgaatctc aaagcagcca agtgcatact ctatgtcatt ttcatgggac tggtctggcc 32640 acaactacat taatgaaata tttgccacat cctcttacac tttttcatac attgcccaag 32700 aataaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca gaaaatttcg 32760 aatcattttt cattcagtag tatagcccca ccaccacata gcttatacag atcaccgtac 32820 cttaatcaaa cctacatggg ggtagagtca taatcgtgca tcaggatagg gcggtggtgc 32880 tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga atacaacatg 32940 gcagtggtct cctcagcgat gattcgcacc gcccgcagca taaggcgcct tgtcctccgg 33000 gcacagcagc gcaccctgat ctcacttaaa tcagcacagt aactgcagca cagcaccaca 33060 atattgttca aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc ggggaccaca 33120 gaacccacgt ggccatcata ccacaagcgc aggtagatta agtggcgacc cctcataaac 33180 acgctggaca taaacattac ctcttttggc atgttgtaat tcaccacctc ccggtaccat 33240 ataaacctct gattaaacat ggcgccatcc accaccatcc taaaccagct ggccaaaacc 33300 tgcccgccgg ctatacactg cagggaaccg ggactggaac aatgacagtg gagagcccag 33360 gactcgtaac catggatcat catgctcgtc atgatatcaa tgttggcaca acacaggcac 33420 acgtgcatac acttcctcag gattacaagc tcctcccgcg ttagaaccat atcccaggga 33480 acaacccatt cctgaatcag cgtaaatccc acactgcagg gaagacctcg cacgtaactc 33540 acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc cagtatggta 33600 gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac tgtacggagt gcgccgagac 33660 aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt agtcatattt 33720 cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg cgtctccggt ctcgccgctt 33780 agatcgctct gtgtagtagt tgtagtatat ccactctctc aaagcatcca ggcgccccct 33840 ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc ctgataacat ccaccaccgc 33900 agaataagcc acacccagcc aacctacaca ttcgttctgc gagtcacaca cgggaggagc 33960 gggaagagct ggaagaacca tgtttttttt tttattccaa aagattatcc aaaacctcaa 34020 aatgaagatc tattaagtga acgcgctccc ctccggtggc gtggtcaaac tctacagcca 34080 aagaacagat aatggcattt gtaagatgtt gcacaatggc ttccaaaagg caaacggccc 34140 tcacgtccaa gtggacgtaa aggctaaacc cttcagggtg aatctcctct ataaacattc 34200 cagcaccttc aaccatgccc aaataattct catctcgcca ccttctcaat atatctctaa 34260 gcaaatcccg aatattaagt ccggccattg taaaaatctg ctccagagcg ccctccacct 34320 tcagcctcaa gcagcgaatc atgattgcaa aaattcaggt tcctcacaga cctgtataag 34380 attcaaaagc ggaacattaa caaaaatacc gcgatcccgt aggtcccttc gcagggccag 34440 ctgaacataa tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc caggaaccat 34500 gacaaaagaa cccacactga ttatgacacg catactcgga gctatgctaa ccagcgtagc 34560 cccgatgtaa gcttgttgca tgggcggcga tataaaatgc aaggtgctgc tcaaaaaatc 34620 aggcaaagcc tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca gataaaggca 34680 ggtaagctcc ggaaccacca cagaaaaaga caccattttt ctctcaaaca tgtctgcggg 34740 tttctgcata aacacaaaat aaaataacaa aaaaacattt aaacattaga agcctgtctt 34800 acaacaggaa aaacaaccct tataagcata agacggacta cggccatgcc ggcgtgaccg 34860 taaaaaaact ggtcaccgtg attaaaaagc accaccgaca gctcctcggt catgtccgga 34920 gtcataatgt aagactcggt aaacacatca ggttgattca catcggtcag tgctaaaaag 34980 cgaccgaaat agcccggggg aatacatacc cgcaggcgta gagacaacat tacagccccc 35040 ataggaggta taacaaaatt aataggagag aaaaacacat aaacacctga aaaaccctcc 35100 tgcctaggca aaatagcacc ctcccgctcc agaacaacat acagcgcttc cacagcggca 35160 gccataacag tcagccttac cagtaaaaaa gaaaacctat taaaaaaaca ccactcgaca 35220 cggcaccagc tcaatcagtc acagtgtaaa aaagggccaa gtgcagagcg agtatatata 35280 ggactaaaaa atgacgtaac ggttaaagtc cacaaaaaac acccagaaaa ccgcacgcga 35340 acctacgccc agaaacgaaa gccaaaaaac ccacaacttc ctcaaatcgt cacttccgtt 35400 ttcccacgtt acgtcacttc ccattttaag aaaactacaa ttcccaacac atacaagtta 35460 ctccgcccta aaacctacgt cacccgcccc gttcccacgc cccgcgccac gtcacaaact 35520 ccaccccctc attatcatat tggcttcaat ccaaaataag gtatattatt gatgatg 35577 <210> 31 <211> 35916 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO442) <400> 31 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagct aagtgtcttg ctgtctttat 4080 ttaggggttt tgcgcgcgcg gtaggcccgg gaccagcggt ctcggtcgtt gagggtcctg 4140 tgtatttttt ccaggacgtg gtaaaggtga ctctggatgt tcagatacat gggcataagc 4200 ccgtctctgg ggtggaggta gcaccactgc agagcttcat gctgcggggt ggtgttgtag 4260 atgatccagt cgtagcagga gcgctgggcg tggtgcctaa aaatgtcttt cagtagcaag 4320 ctgattgcca ggggcaggcc cttggtgtaa gtgtttacaa agcggttaag ctgggatggg 4380 tgcatacgtg gggatatgag atgcatcttg gactgtattt ttaggttggc tatgttccca 4440 gccatatccc tccggggatt catgttgtgc agaaccacca gcacagtgta tccggtgcac 4500 ttgggaaatt tgtcatgtag cttagaagga aatgcgtgga agaacttgga gacgcccttg 4560 tgacctccaa gattttccat gcattcgtcc ataatgatgg caatgggccc acgggcggcg 4620 gcctgggcga agatatttct gggatcacta acgtcatagt tgtgttccag gatgagatcg 4680 tcataggcca tttttacaaa gcgcgggcgg agggtgccag actgcggtat aatggttcca 4740 tccggcccag gggcgtagtt accctcacag atttgcattt cccacgcttt gagttcagat 4800 ggggggatca tgtctacctg cggggcgatg aagaaaacgg tttccggggt aggggagatc 4860 agctgggaag aaagcaggtt cctgagcagc tgcgacttac cgcagccggt gggcccgtaa 4920 atcacaccta ttaccgggtg caactggtag ttaagagagc tgcagctgcc gtcatccctg 4980 agcagggggg ccacttcgtt aagcatgtcc ctgactcgca tgttttccct gaccaaatcc 5040 gccagaaggc gctcgccgcc cagcgatagc agttcttgca aggaagcaaa gtttttcaac 5100 ggtttgagac cgtccgccgt aggcatgctt ttgagcgttt gaccaagcag ttccaggcgg 5160 tcccacagct cggtcacctg ctctacggca tctcgatcca gcatatctcc tcgtttcgcg 5220 ggttggggcg gctttcgctg tacggcagta gtcggtgctc gtccagacgg gccagggtca 5280 tgtctttcca cgggcgcagg gtcctcgtca gcgtagtctg ggtcacggtg aaggggtgcg 5340 ctccgggctg cgcgctggcc agggtgcgct tgaggctggt cctgctggtg ctgaagcgct 5400 gccggtcttc gccctgcgcg tcggccaggt agcatttgac catggtgtca tagtccagcc 5460 cctccgcggc gtggcccttg gcgcgcagct tgcccttgga ggaggcgccg cacgaggggc 5520 agtgcagact tttgagggcg tagagcttgg gcgcgagaaa taccgattcc ggggagtagg 5580 catccgcgcc gcaggccccg cagacggtct cgcattccac gagccaggtg agctctggcc 5640 gttcggggtc aaaaaccagg tttcccccat gctttttgat gcgtttctta cctctggttt 5700 ccatgagccg gtgtccacgc tcggtgacga aaaggctgtc cgtgtccccg tatacagact 5760 tgagaggcct gtcctcgagc ggtgttccgc ggtcctcctc gtatagaaac tcggaccact 5820 ctgagacaaa ggctcgcgtc caggccagca cgaaggaggc taagtgggag gggtagcggt 5880 cgttgtccac tagggggtcc actcgctcca gggtgtgaag acacatgtcg ccctcttcgg 5940 catcaaggaa ggtgattggt ttgtaggtgt aggccacgtg accgggtgtt cctgaagggg 6000 ggctataaaa gggggtgggg gcgcgttcgt cctcactctc ttccgcatcg ctgtctgcga 6060 gggccagctg ttggggtgag tactccctct gaaaagcggg catgacttct gcgctaagat 6120 tgtcagtttc caaaaacgag gaggatttga tattcacctg gcccgcggtg atgcctttga 6180 gggtggccgc atccatctgg tcagaaaaga caatcttttt gttgtcaagc ttggtggcaa 6240 acgacccgta gagggcgttg gacagcaact tggcgatgga gcgcagggtt tggtttttgt 6300 cgcgatcggc gcgctccttg gccgcgatgt ttagctgcac gtattcgcgc gcaacgcacc 6360 gccattcggg aaagacggtg gtgcgctcgt cgggcaccag gtgcacgcgc caaccgcggt 6420 tgtgcagggt gacaaggtca acgctggtgg ctacctctcc gcgtaggcgc tcgttggtcc 6480 agcagaggcg gccgcccttg cgcgagcaga atggcggtag ggggtctagc tgcgtctcgt 6540 ccggggggtc tgcgtccacg gtaaagaccc cgggcagcag gcgcgcgtcg aagtagtcta 6600 tcttgcatcc ttgcaagtct agcgcctgct gccatgcgcg ggcggcaagc gcgcgctcgt 6660 atgggttgag tgggggaccc catggcatgg ggtgggtgag cgcggaggcg tacatgccgc 6720 aaatgtcgta aacgtagagg ggctctctga gtattccaag atatgtaggg tagcatcttc 6780 caccgcggat gctggcgcgc acgtaatcgt atagttcgtg cgagggagcg aggaggtcgg 6840 gaccgaggtt gctacgggcg ggctgctctg ctcggaagac tatctgcctg aagatggcat 6900 gtgagttgga tgatatggtt ggacgctgga agacgttgaa gctggcgtct gtgagaccta 6960 ccgcgtcacg cacgaaggag gcgtaggagt cgcgcagctt gttgaccagc tcggcggtga 7020 cctgcacgtc tagggcgcag tagtccaggg tttccttgat gatgtcatac ttatcctgtc 7080 cctttttttt ccacagctcg cggttgagga caaactcttc gcggtctttc cagtactctt 7140 ggatcggaaa cccgtcggcc tccgaacggt aagagcctag catgtagaac tggttgacgg 7200 cctggtaggc gcagcatccc ttttctacgg gtagcgcgta tgcctgcgcg gccttccgga 7260 gcgaggtgtg ggtgagcgca aaggtgtccc tgaccatgac tttgaggtac tggtatttga 7320 agtcagtgtc gtcgcatccg ccctgctccc agagcaaaaa gtccgtgcgc tttttggaac 7380 gcggatttgg cagggcgaag gtgacatcgt tgaagagtat ctttcccgcg cgaggcataa 7440 agttgcgtgt gatgcggaag ggtcccggca cctcggaacg gttgttaatt acctgggcgg 7500 cgagcacgat ctcgtcaaag ccgttgatgt tgtggcccac aatgtaaagt tccaagaagc 7560 gcgggatgcc cttgatggaa ggcaattttt taagttcctc gtaggtgagc tcttcagggg 7620 agctgagccc gtgctctgaa agggcccagt ctgcaagatg agggttggaa gcgacgaatg 7680 agctccacag gtcacgggcc attagcattt gcaggtggtc gcgaaaggtc ctaaactggc 7740 gacctatggc cattttttct ggggtgatgc agtagaaggt aagcgggtct tgttcccagc 7800 ggtcccatcc aaggttcgcg gctaggtctc gcgcggcagt cactagaggc tcatctccgc 7860 cgaacttcat gaccagcatg aagggcacga gctgcttccc aaaggccccc atccaagtat 7920 aggtctctac atcgtaggtg acaaagagac gctcggtgcg aggatgcgag ccgatcggga 7980 agaactggat ctcccgccac caattggagg agtggctatt gatgtggtga aagtagaagt 8040 ccctgcgacg ggccgaacac tcgtgctggc ttttgtaaaa acgtgcgcag tactggcagc 8100 ggtgcacggg ctgtacatcc tgcacgaggt tgacctgacg accgcgcaca aggaagcaga 8160 gtgggaattt gagcccctcg cctggcgggt ttggctggtg gtcttctact tcggctgctt 8220 gtccttgacc gtctggctgc tcgaggggag ttacggtgga tcggaccacc acgccgcgcg 8280 agcccaaagt ccagatgtcc gcgcgcggcg gtcggagctt gatgacaaca tcgcgcagat 8340 gggagctgtc catggtctgg agctcccgcg gcgtcaggtc aggcgggagc tcctgcaggt 8400 ttacctcgca tagacgggtc agggcgcggg ctagatccag gtgataccta atttccaggg 8460 gctggttggt ggcggcgtcg atggcttgca agaggccgca tccccgcggc gcgactacgg 8520 taccgcgcgg cgggcggtgg gccgcggggg tgtccttgga tgatgcatct aaaagcggtg 8580 acgcgggcga gcccccggag gtaggggggg ctccggaccc gccgggagag ggggcagggg 8640 cacgtcggcg ccgcgcgcgg gcaggagctg gtgctgcgcg cgtaggttgc tggcgaacgc 8700 gacgacgcgg cggttgatct cctgaatctg gcgcctctgc gtgaagacga cgggcccggt 8760 gagcttgagc ctgaaagaga gttcgacaga atcaatttcg gtgtcgttga cggcggcctg 8820 gcgcaaaatc tcctgcacgt ctcctgagtt gtcttgatag gcgatctcgg ccatgaactg 8880 ctcgatctct tcctcctgga gatctccgcg tccggctcgc tccacggtgg cggcgaggtc 8940 gttggaaatg cgggccatga gctgcgagaa ggcgttgagg cctccctcgt tccagacgcg 9000 gctgtagacc acgccccctt cggcatcgcg ggcgcgcatg accacctgcg cgagattgag 9060 ctccacgtgc cgggcgaaga cggcgtagtt tcgcaggcgc tgaaagaggt agttgagggt 9120 ggtggcggtg tgttctgcca cgaagaagta cataacccag cgtcgcaacg tggattcgtt 9180 gatatccccc aaggcctcaa ggcgctccat ggcctcgtag aagtccacgg cgaagttgaa 9240 aaactgggag ttgcgcgccg acacggttaa ctcctcctcc agaagacgga tgagctcggc 9300 gacagtgtcg cgcacctcgc gctcaaaggc tacaggggcc tcttcttctt cttcaatctc 9360 ctcttccata agggcctccc cttcttcttc ttctggcggc ggtgggggag gggggacacg 9420 gcggcgacga cggcgcaccg ggaggcggtc gacaaagcgc tcgatcatct ccccgcggcg 9480 acggcgcatg gtctcggtga cggcgcggcc gttctcgcgg gggcgcagtt ggaagacgcc 9540 gcccgtcatg tcccggttat gggttggcgg ggggctgcca tgcggcaggg atacggcgct 9600 aacgatgcat ctcaacaatt gttgtgtagg tactccgccg ccgagggacc tgagcgagtc 9660 cgcatcgacc ggatcggaaa acctctcgag aaaggcgtct aaccagtcac agtcgcaagg 9720 taggctgagc accgtggcgg gcggcagcgg gcggcggtcg gggttgtttc tggcggaggt 9780 gctgctgatg atgtaattaa agtaggcggt cttgagacgg cggatggtcg acagaagcac 9840 catgtccttg ggtccggcct gctgaatgcg caggcggtcg gccatgcccc aggcttcgtt 9900 ttgacatcgg cgcaggtctt tgtagtagtc ttgcatgagc ctttctaccg gcacttcttc 9960 ttctccttcc tcttgtcctg catctcttgc atctatcgct gcggcggcgg cggagtttgg 10020 ccgtaggtgg cgccctcttc ctcccatgcg tgtgaccccg aagcccctca tcggctgaag 10080 cagggctagg tcggcgacaa cgcgctcggc taatatggcc tgctgcacct gcgtgagggt 10140 agactggaag tcatccatgt ccacaaagcg gtggtatgcg cccgtgttga tggtgtaagt 10200 gcagttggcc ataacggacc agttaacggt ctggtgaccc ggctgcgaga gctcggtgta 10260 cctgagacgc gagtaagccc tcgagtcaaa tacgtagtcg ttgcaagtcc gcaccaggta 10320 ctggtatccc accaaaaagt gcggcggcgg ctggcggtag aggggccagc gtagggtggc 10380 cggggctccg ggggcgagat cttccaacat aaggcgatga tatccgtaga tgtacctgga 10440 catccaggtg atgccggcgg cggtggtgga ggcgcgcgga aagtcgcgga cgcggttcca 10500 gatgttgcgc agcggcaaaa agtgctccat ggtcgggacg ctctggccgg tcaggcgcgc 10560 gcaatcgttg acgctctaga ccgtgcaaaa ggagagcctg taagcgggca ctcttccgtg 10620 gtctggtgga taaattcgca agggtatcat ggcggacgac cggggttcga gccccgtatc 10680 cggccgtccg ccgtgatcca tgcggttacc gcccgcgtgt cgaacccagg tgtgcgacgt 10740 cagacaacgg gggagtgctc cttttggctt ccttccaggc gcggcggctg ctgcgctagc 10800 ttttttggcc actggccgcg cgcagcgtaa gcggttaggc tggaaagcga aagcattaag 10860 tggctcgctc cctgtagccg gagggttatt ttccaagggt tgagtcgcgg gacccccggt 10920 tcgagtctcg gaccggccgg actgcggcga acgggggttt gcctccccgt catgcaagac 10980 cccgcttgca aattcctccg gaaacaggga cgagcccctt ttttgctttt cccagatgca 11040 tccggtgctg cggcagatgc gcccccctcc tcagcagcgg caagagcaag agcagcggca 11100 gacatgcagg gcaccctccc ctcctcctac cgcgtcagga ggggcgacat ccgcggttga 11160 cgcggcagca gatggtgatt acgaaccccc gcggcgccgg gcccggcact acctggactt 11220 ggaggagggc gagggcctgg cgcggctagg agcgccctct cctgagcggt acccaagggt 11280 gcagctgaag cgtgatacgc gtgaggcgta cgtgccgcgg cagaacctgt ttcgcgaccg 11340 cgagggagag gagcccgagg agatgcggga tcgaaagttc cacgcagggc gcgagctgcg 11400 gcatggcctg aatcgcgagc ggttgctgcg cgaggaggac tttgagcccg acgcgcgaac 11460 cgggattagt cccgcgcgcg cacacgtggc ggccgccgac ctggtaaccg catacgagca 11520 gacggtgaac caggagatta actttcaaaa aagctttaac aaccacgtgc gtacgcttgt 11580 ggcgcgcgag gaggtggcta taggactgat gcatctgtgg gactttgtaa gcgcgctgga 11640 gcaaaaccca aatagcaagc cgctcatggc gcagctgttc cttatagtgc agcacagcag 11700 ggacaacgag gcattcaggg atgcgctgct aaacatagta gagcccgagg gccgctggct 11760 gctcgatttg ataaacatcc tgcagagcat agtggtgcag gagcgcagct tgagcctggc 11820 tgacaaggtg gccgccatca actattccat gcttagcctg ggcaagtttt acgcccgcaa 11880 gatataccat accccttacg ttcccataga caaggaggta aagatcgagg ggttctacat 11940 gcgcatggcg ctgaaggtgc ttaccttgag cgacgacctg ggcgtttatc gcaacgagcg 12000 catccacaag gccgtgagcg tgagccggcg gcgcgagctc agcgaccgcg agctgatgca 12060 cagcctgcaa agggccctgg ctggcacggg cagcggcgat agagaggccg agtcctactt 12120 tgacgcgggc gctgacctgc gctgggcccc aagccgacgc gccctggagg cagctggggc 12180 cggacctggg ctggcggtgg cacccgcgcg cgctggcaac gtcggcggcg tggaggaata 12240 tgacgaggac gatgagtacg agccagagga cggcgagtac taagcggtga tgtttctgat 12300 cagatgatgc aagacgcaac ggacccggcg gtgcgggcgg cgctgcagag ccagccgtcc 12360 ggccttaact ccacggacga ctggcgccag gtcatggacc gcatcatgtc gctgactgcg 12420 cgcaatcctg acgcgttccg gcagcagccg caggccaacc ggctctccgc aattctggaa 12480 gcggtggtcc cggcgcgcgc aaaccccacg cacgagaagg tgctggcgat cgtaaacgcg 12540 ctggccgaaa acagggccat ccggcccgac gaggccggcc tggtctacga cgcgctgctt 12600 cagcgcgtgg ctcgttacaa cagcggcaac gtgcagacca acctggaccg gctggtgggg 12660 gatgtgcgcg aggccgtggc gcagcgtgag cgcgcgcagc agcagggcaa cctgggctcc 12720 atggttgcac taaacgcctt cctgagtaca cagcccgcca acgtgccgcg gggacaggag 12780 gactacacca actttgtgag cgcactgcgg ctaatggtga ctgagacacc gcaaagtgag 12840 gtgtaccagt ctgggccaga ctattttttc cagaccagta gacaaggcct gcagaccgta 12900 aacctgagcc aggctttcaa aaacttgcag gggctgtggg gggtgcgggc tcccacaggc 12960 gaccgcgcga ccgtgtctag cttgctgacg cccaactcgc gcctgttgct gctgctaata 13020 gcgcccttca cggacagtgg cagcgtgtcc cgggacacat acctaggtca cttgctgaca 13080 ctgtaccgcg aggccatagg tcaggcgcat gtggacgagc atactttcca ggagattaca 13140 agtgtcagcc gcgcgctggg gcaggaggac acgggcagcc tggaggcaac cctaaactac 13200 ctgctgacca accggcggca gaagatcccc tcgttgcaca gtttaaacag cgaggaggag 13260 cgcattttgc gctacgtgca gcagagcgtg agccttaacc tgatgcgcga cggggtaacg 13320 cccagcgtgg cgctggacat gaccgcgcgc aacatggaac cgggcatgta tgcctcaaac 13380 cggccgttta tcaaccgcct aatggactac ttgcatcgcg cggccgccgt gaaccccgag 13440 tatttcacca atgccatctt gaacccgcac tggctaccgc cccctggttt ctacaccggg 13500 ggattcgagg tgcccgaggg taacgatgga ttcctctggg acgacataga cgacagcgtg 13560 ttttccccgc aaccgcagac cctgctagag ttgcaacagc gcgagcaggc agaggcggcg 13620 ctgcgaaagg aaagcttccg caggccaagc agcttgtccg atctaggcgc tgcggccccg 13680 cggtcagatg ctagtagccc atttccaagc ttgatagggt ctcttaccag cactcgcacc 13740 acccgcccgc gcctgctggg cgaggaggag tacctaaaca actcgctgct gcagccgcag 13800 cgcgaaaaaa acctgcctcc ggcatttccc aacaacggga tagagagcct agtggacaag 13860 atgagtagat ggaagacgta cgcgcaggag cacagggacg tgccaggccc gcgcccgccc 13920 acccgtcgtc aaaggcacga ccgtcagcgg ggtctggtgt gggaggacga tgactcggca 13980 gacgacagca gcgtcctgga tttgggaggg agtggcaacc cgtttgcgca ccttcgcccc 14040 aggctgggga gaatgtttta aaaaaaaaaa agcatgatgc aaaataaaaa actcaccaag 14100 gccatggcac cgagcgttgg ttttcttgta ttccccttag tatgcggcgc gcggcgatgt 14160 atgaggaagg tcctcctccc tcctacgaga gtgtggtgag cgcggcgcca gtggcggcgg 14220 cgctgggttc tcccttcgat gctcccctgg acccgccgtt tgtgcctccg cggtacctgc 14280 ggcctaccgg ggggagaaac agcatccgtt actctgagtt ggcaccccta ttcgacacca 14340 cccgtgtgta cctggtggac aacaagtcaa cggatgtggc atccctgaac taccagaacg 14400 accacagcaa ctttctgacc acggtcattc aaaacaatga ctacagcccg ggggaggcaa 14460 gcacacagac catcaatctt gacgaccggt cgcactgggg cggcgacctg aaaaccatcc 14520 tgcataccaa catgccaaat gtgaacgagt tcatgtttac caataagttt aaggcgcggg 14580 tgatggtgtc gcgcttgcct actaaggaca atcaggtgga gctgaaatac gagtgggtgg 14640 agttcacgct gcccgagggc aactactccg agaccatgac catagacctt atgaacaacg 14700 cgatcgtgga gcactacttg aaagtgggca gacagaacgg ggttctggaa agcgacatcg 14760 gggtaaagtt tgacacccgc aacttcagac tggggtttga ccccgtcact ggtcttgtca 14820 tgcctggggt atatacaaac gaagccttcc atccagacat cattttgctg ccaggatgcg 14880 gggtggactt cacccacagc cgcctgagca acttgttggg catccgcaag cggcaaccct 14940 tccaggaggg ctttaggatc acctacgatg atctggaggg tggtaacatt cccgcactgt 15000 tggatgtgga cgcctaccag gcgagcttga aagatgacac cgaacagggc gggggtggcg 15060 caggcggcag caacagcagt ggcagcggcg cggaagagaa ctccaacgcg gcagccgcgg 15120 caatgcagcc ggtggaggac atgaacgatc atgccattcg cggcgacacc tttgccacac 15180 gggctgagga gaagcgcgct gaggccgaag cagcggccga agctgccgcc cccgctgcgc 15240 aacccgaggt cgagaagcct cagaagaaac cggtgatcaa acccctgaca gaggacagca 15300 agaaacgcag ttacaaccta ataagcaatg acagcacctt cacccagtac cgcagctggt 15360 accttgcata caactacggc gaccctcaga ccggaatccg ctcatggacc ctgctttgca 15420 ctcctgacgt aacctgcggc tcggagcagg tctactggtc gttgccagac atgatgcaag 15480 accccgtgac cttccgctcc acgcgccaga tcagcaactt tccggtggtg ggcgccgagc 15540 tgttgcccgt gcactccaag agcttctaca acgaccaggc cgtctactcc caactcatcc 15600 gccagtttac ctctctgacc cacgtgttca atcgctttcc cgagaaccag attttggcgc 15660 gcccgccagc ccccaccatc accaccgtca gtgaaaacgt tcctgctctc acagatcacg 15720 ggacgctacc gctgcgcaac agcatcggag gagtccagcg agtgaccatt actgacgcca 15780 gacgccgcac ctgcccctac gtttacaagg ccctgggcat agtctcgccg cgcgtcctat 15840 cgagccgcac tttttgagca agcatgtcca tccttatatc gcccagcaat aacacaggct 15900 ggggcctgcg cttcccaagc aagatgtttg gcggggccaa gaagcgctcc gaccaacacc 15960 cagtgcgcgt gcgcgggcac taccgcgcgc cctggggcgc gcacaaacgc ggccgcactg 16020 ggcgcaccac cgtcgatgac gccatcgacg cggtggtgga ggaggcgcgc aactacacgc 16080 ccacgccgcc accagtgtcc acagtggacg cggccattca gaccgtggtg cgcggagccc 16140 ggcgctatgc taaaatgaag agacggcgga ggcgcgtagc acgtcgccac cgccgccgac 16200 ccggcactgc cgcccaacgc gcggcggcgg ccctgcttaa ccgcgcacgt cgcaccggcc 16260 gacgggcggc catgcgggcc gctcgaaggc tggccgcggg tattgtcact gtgcccccca 16320 ggtccaggcg acgagcggcc gccgcagcag ccgcggccat tagtgctatg actcagggtc 16380 gcaggggcaa cgtgtattgg gtgcgcgact cggttagcgg cctgcgcgtg cccgtgcgca 16440 cccgcccccc gcgcaactag attgcaagaa aaaactactt agactcgtac tgttgtatgt 16500 atccagcggc ggcggcgcgc aacgaagcta tgtccaagcg caaaatcaaa gaagagatgc 16560 tccaggtcat cgcgccggag atctatggcc ccccgaagaa ggaagagcag gattacaagc 16620 cccgaaagct aaagcgggtc aaaaagaaaa agaaagatga tgatgatgaa cttgacgacg 16680 aggtggaact gctgcacgct accgcgccca ggcgacgggt acagtggaaa ggtcgacgcg 16740 taaaacgtgt tttgcgaccc ggcaccaccg tagtctttac gcccggtgag cgctccaccc 16800 gcacctacaa gcgcgtgtat gatgaggtgt acggcgacga ggacctgctt gagcaggcca 16860 acgagcgcct cggggagttt gcctacggaa agcggcataa ggacatgctg gcgttgccgc 16920 tggacgaggg caacccaaca cctagcctaa agcccgtaac actgcagcag gtgctgcccg 16980 cgcttgcacc gtccgaagaa aagcgcggcc taaagcgcga gtctggtgac ttggcaccca 17040 ccgtgcagct gatggtaccc aagcgccagc gactggaaga tgtcttggaa aaaatgaccg 17100 tggaacctgg gctggagccc gaggtccgcg tgcggccaat caagcaggtg gcgccgggac 17160 tgggcgtgca gaccgtggac gttcagatac ccactaccag tagcaccagt attgccaccg 17220 ccacagaggg catggagaca caaacgtccc cggttgcctc agcggtggcg gatgccgcgg 17280 tgcaggcggt cgctgcggcc gcgtccaaga cctctacgga ggtgcaaacg gacccgtgga 17340 tgtttcgcgt ttcagccccc cggcgcccgc gcggttcgag gaagtacggc gccgccagcg 17400 cgctactgcc cgaatatgcc ctacatcctt ccattgcgcc tacccccggc tatcgtggct 17460 acacctaccg ccccagaaga cgagcaacta cccgacgccg aaccaccact ggaacccgcc 17520 gccgccgtcg ccgtcgccag cccgtgctgg ccccgatttc cgtgcgcagg gtggctcgcg 17580 aaggaggcag gaccctggtg ctgccaacag cgcgctacca ccccagcatc gtttaaaagc 17640 cggtctttgt ggttcttgca gatatggccc tcacctgccg cctccgtttc ccggtgccgg 17700 gattccgagg aagaatgcac cgtaggaggg gcatggccgg ccacggcctg acgggcggca 17760 tgcgtcgtgc gcaccaccgg cggcggcgcg cgtcgcaccg tcgcatgcgc ggcggtatcc 17820 tgcccctcct tattccactg atcgccgcgg cgattggcgc cgtgcccgga attgcatccg 17880 tggccttgca ggcgcagaga cactgattaa aaacaagttg catgtggaaa aatcaaaata 17940 aaaagtctgg actctcacgc tcgcttggtc ctgtaactat tttgtagaat ggaagacatc 18000 aactttgcgt ctctggcccc gcgacacggc tcgcgcccgt tcatgggaaa ctggcaagat 18060 atcggcacca gcaatatgag cggtggcgcc ttcagctggg gctcgctgtg gagcggcatt 18120 aaaaatttcg gttccaccgt taagaactat ggcagcaagg cctggaacag cagcacaggc 18180 cagatgctga gggataagtt gaaagagcaa aatttccaac aaaaggtggt agatggcctg 18240 gcctctggca ttagcggggt ggtggacctg gccaaccagg cagtgcaaaa taagattaac 18300 agtaagcttg atccccgccc tcccgtagag gagcctccac cggccgtgga gacagtgtct 18360 ccagaggggc gtggcgaaaa gcgtccgcgc cccgacaggg aagaaactct ggtgacgcaa 18420 atagacgagc ctccctcgta cgaggaggca ctaaagcaag gcctgcccac cacccgtccc 18480 atcgcgccca tggctaccgg agtgctgggc cagcacacac ccgtaacgct ggacctgcct 18540 ccccccgccg acacccagca gaaacctgtg ctgccaggcc cgaccgccgt tgttgtaacc 18600 cgtcctagcc gcgcgtccct gcgccgcgcc gccagcggtc cgcgatcgtt gcggcccgta 18660 gccagtggca actggcaaag cacactgaac agcatcgtgg gtctgggggt gcaatccctg 18720 aagcgccgac gatgcttctg aatagctaac gtgtcgtatg tgtgtcatgt atgcgtccat 18780 gtcgccgcca gaggagctgc tgagccgccg cgcgcccgct ttccaagatg gctacccctt 18840 cgatgatgcc gcagtggtct tacatgcaca tctcgggcca ggacgcctcg gagtacctga 18900 gccccgggct ggtgcagttt gcccgcgcca ccgagacgta cttcagcctg aataacaagt 18960 ttagaaaccc cacggtggcg cctacgcacg acgtgaccac agaccggtcc cagcgtttga 19020 cgctgcggtt catccctgtg gaccgtgagg atactgcgta ctcgtacaag gcgcggttca 19080 ccctagctgt gggtgataac cgtgtgctgg acatggcttc cacgtacttt gacatccgcg 19140 gcgtgctgga caggggccct acttttaagc cctactctgg cactgcctac aacgccctgg 19200 ctcccaaggg tgccccaaat ccttgcgaat gggatgaagc tgctactgct cttgaaataa 19260 acctagaaga agaggacgat gacaacgaag acgaagtaga cgagcaagct gagcagcaaa 19320 aaactcacgt atttgggcag gcgccttatt ctggtataaa tattacaaag gagggtattc 19380 aaataggtgt cgaaggtcaa acacctaaat atgccgataa aacatttcaa cctgaacctc 19440 aaataggaga atctcagtgg tacgaaactg aaattaatca tgcagctggg agagtcctta 19500 aaaagactac cccaatgaaa ccatgttacg gttcatatgc aaaacccaca aatgaaaatg 19560 gagggcaagg cattcttgta aagcaacaaa atggaaagct agaaagtcaa gtggaaatgc 19620 aatttttctc aactactgag gcgaccgcag gcaatggtga taacttgact cctaaagtgg 19680 tattgtacag tgaagatgta gatatagaaa ccccagacac tcatatttct tacatgccca 19740 ctattaagga aggtaactca cgagaactaa tgggccaaca atctatgccc aacaggccta 19800 attacattgc ttttagggac aattttattg gtctaatgta ttacaacagc acgggtaata 19860 tgggtgttct ggcgggccaa gcatcgcagt tgaatgctgt tgtagatttg caagacagaa 19920 acacagagct ttcataccag cttttgcttg attccattgg tgatagaacc aggtactttt 19980 ctatgtggaa tcaggctgtt gacagctatg atccagatgt tagaattatt gaaaatcatg 20040 gaactgaaga tgaacttcca aattactgct ttccactggg aggtgtgatt aatacagaga 20100 ctcttaccaa ggtaaaacct aaaacaggtc aggaaaatgg atgggaaaaa gatgctacag 20160 aattttcaga taaaaatcaa ataagagttg gaaataattt tgccatggaa atcaatctaa 20220 atgccaacct gtggagaaat ttcctgtact ccaacatagc gctgtatttg cccgacaagc 20280 taaagtacag tccttccaac gtaaaaattt ctgataaccc aaacacctac gactacatga 20340 acaagcgagt ggtggctccc gggttagtgg actgctacat taaccttgga gcacgctggt 20400 cccttgacta tatggacaac gtcaacccat ttaaccacca ccgcaatgct ggcctgcgct 20460 accgctcaat gttgctgggc aatggtcgct atgtgccctt ccacatccag gtgcctcaga 20520 agttctttgc cattaaaaac ctccttctcc tgccgggctc atacacctac gagtggaact 20580 tcaggaagga tgttaacatg gttctgcaga gctccctagg aaatgaccta agggttgacg 20640 gagccagcat taagtttgat agcatttgcc tttacgccac cttcttcccc atggcccaca 20700 acaccgcctc cacgcttgag gccatgctta gaaacgacac caacgaccag tcctttaacg 20760 actatctctc cgccgccaac atgctctacc ctatacccgc caacgctacc aacgtgccca 20820 tatccatccc ctcccgcaac tgggcggctt tccgcggctg ggccttcacg cgccttaaga 20880 ctaaggaaac cccatcactg ggctcgggct acgaccctta ttacacctac tctggctcta 20940 taccctacct agatggaacc ttttacctca accacacctt taagaaggtg gccattacct 21000 ttgactcttc tgtcagctgg cctggcaatg accgcctgct tacccccaac gagtttgaaa 21060 ttaagcgctc agttgacggg gagggttaca acgttgccca gtgtaacatg accaaagact 21120 ggttcctggt acaaatgcta gctaactaca acattggcta ccagggcttc tatatcccag 21180 agagctacaa ggaccgcatg tactccttct ttagaaactt ccagcccatg agccgtcagg 21240 tggtggatga tactaaatac aaggactacc aacaggtggg catcctacac caacacaaca 21300 actctggatt tgttggctac cttgccccca ccatgcgcga aggacaggcc taccctgcta 21360 acttccccta tccgcttata ggcaagaccg cagttgacag cattacccag aaaaagtttc 21420 tttgcgatcg caccctttgg cgcatcccat tctccagtaa ctttatgtcc atgggcgcac 21480 tcacagacct gggccaaaac cttctctacg ccaactccgc ccacgcgcta gacatgactt 21540 ttgaggtgga tcccatggac gagcccaccc ttctttatgt tttgtttgaa gtctttgacg 21600 tggtccgtgt gcaccggccg caccgcggcg tcatcgaaac cgtgtacctg cgcacgccct 21660 tctcggccgg caacgccaca acataaagaa gcaagcaaca tcaacaacag ctgccgccat 21720 gggctccagt gagcaggaac tgaaagccat tgtcaaagat cttggttgtg ggccatattt 21780 tttgggcacc tatgacaagc gctttccagg ctttgtttct ccacacaagc tcgcctgcgc 21840 catagtcaat acggccggtc gcgagactgg gggcgtacac tggatggcct ttgcctggaa 21900 cccgcactca aaaacatgct acctctttga gccctttggc ttttctgacc agcgactcaa 21960 gcaggtttac cagtttgagt acgagtcact cctgcgccgt agcgccattg cttcttcccc 22020 cgaccgctgt ataacgctgg aaaagtccac ccaaagcgta caggggccca actcggccgc 22080 ctgtggacta ttctgctgca tgtttctcca cgcctttgcc aactggcccc aaactcccat 22140 ggatcacaac cccaccatga accttattac cggggtaccc aactccatgc tcaacagtcc 22200 ccaggtacag cccaccctgc gtcgcaacca ggaacagctc tacagcttcc tggagcgcca 22260 ctcgccctac ttccgcagcc acagtgcgca gattaggagc gccacttctt tttgtcactt 22320 gaaaaacatg taaaaataat gtactagaga cactttcaat aaaggcaaat gcttttattt 22380 gtacactctc gggtgattat ttacccccac ccttgccgtc tgcgccgttt aaaaatcaaa 22440 ggggttctgc cgcgcatcgc tatgcgccac tggcagggac acgttgcgat actggtgttt 22500 agtgctccac ttaaactcag gcacaaccat ccgcggcagc tcggtgaagt tttcactcca 22560 caggctgcgc accatcacca acgcgtttag caggtcgggc gccgatatct tgaagtcgca 22620 gttggggcct ccgccctgcg cgcgcgagtt gcgatacaca gggttgcagc actggaacac 22680 tatcagcgcc gggtggtgca cgctggccag cacgctcttg tcggagatca gatccgcgtc 22740 caggtcctcc gcgttgctca gggcgaacgg agtcaacttt ggtagctgcc ttcccaaaaa 22800 gggcgcgtgc ccaggctttg agttgcactc gcaccgtagt ggcatcaaaa ggtgaccgtg 22860 cccggtctgg gcgttaggat acagcgcctg cataaaagcc ttgatctgct taaaagccac 22920 ctgagccttt gcgccttcag agaagaacat gccgcaagac ttgccggaaa actgattggc 22980 cggacaggcc gcgtcgtgca cgcagcacct tgcgtcggtg ttggagatct gcaccacatt 23040 tcggccccac cggttcttca cgatcttggc cttgctagac tgctccttca gcgcgcgctg 23100 cccgttttcg ctcgtcacat ccatttcaat cacgtgctcc ttatttatca taatgcttcc 23160 gtgtagacac ttaagctcgc cttcgatctc agcgcagcgg tgcagccaca acgcgcagcc 23220 cgtgggctcg tgatgcttgt aggtcacctc tgcaaacgac tgcaggtacg cctgcaggaa 23280 tcgccccatc atcgtcacaa aggtcttgtt gctggtgaag gtcagctgca acccgcggtg 23340 ctcctcgttc agccaggtct tgcatacggc cgccagagct tccacttggt caggcagtag 23400 tttgaagttc gcctttagat cgttatccac gtggtacttg tccatcagcg cgcgcgcagc 23460 ctccatgccc ttctcccacg cagacacgat cggcacactc agcgggttca tcaccgtaat 23520 ttcactttcc gcttcgctgg gctcttcctc ttcctcttgc gtccgcatac cacgcgccac 23580 tgggtcgtct tcattcagcc gccgcactgt gcgcttacct cctttgccat gcttgattag 23640 caccggtggg ttgctgaaac ccaccatttg tagcgccaca tcttctcttt cttcctcgct 23700 gtccacgatt acctctggtg atggcgggcg ctcgggcttg ggagaagggc gcttcttttt 23760 cttcttgggc gcaatggcca aatccgccgc cgaggtcgat ggccgcgggc tgggtgtgcg 23820 cggcaccagc gcgtcttgtg atgagtcttc ctcgtcctcg gactcgatac gccgcctcat 23880 ccgctttttt gggggcgccc ggggaggcgg cggcgacggg gacggggacg acacgtcctc 23940 catggttggg ggacgtcgcg ccgcaccgcg tccgcgctcg ggggtggttt cgcgctgctc 24000 ctcttcccga ctggccattt ccttctccta taggcagaaa aagatcatgg agtcagtcga 24060 gaagaaggac agcctaaccg ccccctctga gttcgccacc accgcctcca ccgatgccgc 24120 caacgcgcct accaccttcc ccgtcgaggc acccccgctt gaggaggagg aagtgattat 24180 cgagcaggac ccaggttttg taagcgaaga cgacgaggac cgctcagtac caacagagga 24240 taaaaagcaa gaccaggaca acgcagaggc aaacgaggaa caagtcgggc ggggggacga 24300 aaggcatggc gactacctag atgtgggaga cgacgtgctg ttgaagcatc tgcagcgcca 24360 gtgcgccatt atctgcgacg cgttgcaaga gcgcagcgat gtgcccctcg ccatagcgga 24420 tgtcagcctt gcctacgaac gccacctatt ctcaccgcgc gtacccccca aacgccaaga 24480 aaacggcaca tgcgagccca acccgcgcct caacttctac cccgtatttg ccgtgccaga 24540 ggtgcttgcc acctatcaca tctttttcca aaactgcaag atacccctat cctgccgtgc 24600 caaccgcagc cgagcggaca agcagctggc cttgcggcag ggcgctgtca tacctgatat 24660 cgcctcgctc aacgaagtgc caaaaatctt tgagggtctt ggacgcgacg agaagcgcgc 24720 ggcaaacgct ctgcaacagg aaaacagcga aaatgaaagt cactctggag tgttggtgga 24780 actcgagggt gacaacgcgc gcctagccgt actaaaacgc agcatcgagg tcacccactt 24840 tgcctacccg gcacttaacc taccccccaa ggtcatgagc acagtcatga gtgagctgat 24900 cgtgcgccgt gcgcagcccc tggagaggga tgcaaatttg caagaacaaa cagaggaggg 24960 cctacccgca gttggcgacg agcagctagc gcgctggctt caaacgcgcg agcctgccga 25020 cttggaggag cgacgcaaac taatgatggc cgcagtgctc gttaccgtgg agcttgagtg 25080 catgcagcgg ttctttgctg acccggagat gcagcgcaag ctagaggaaa cattgcacta 25140 cacctttcga cagggctacg tacgccaggc ctgcaagatc tccaacgtgg agctctgcaa 25200 cctggtctcc taccttggaa ttttgcacga aaaccgcctt gggcaaaacg tgcttcattc 25260 cacgctcaag ggcgaggcgc gccgcgacta cgtccgcgac tgcgtttact tatttctatg 25320 ctacacctgg cagacggcca tgggcgtttg gcagcagtgc ttggaggagt gcaacctcaa 25380 ggagctgcag aaactgctaa agcaaaactt gaaggaccta tggacggcct tcaacgagcg 25440 ctccgtggcc gcgcacctgg cggacatcat tttccccgaa cgcctgctta aaaccctgca 25500 acagggtctg ccagacttca ccagtcaaag catgttgcag aactttagga actttatcct 25560 agagcgctca ggaatcttgc ccgccacctg ctgtgcactt cctagcgact ttgtgcccat 25620 taagtaccgc gaatgccctc cgccgctttg gggccactgc taccttctgc agctagccaa 25680 ctaccttgcc taccactctg acataatgga agacgtgagc ggtgacggtc tactggagtg 25740 tcactgtcgc tgcaacctat gcaccccgca ccgctccctg gtttgcaatt cgcagctgct 25800 taacgaaagt caaattatcg gtacctttga gctgcagggt ccctcgcctg acgaaaagtc 25860 cgcggctccg gggttgaaac tcactccggg gctgtggacg tcggcttacc ttcgcaaatt 25920 tgtacctgag gactaccacg cccacgagat taggttctac gaagaccaat cccgcccgcc 25980 aaatgcggag cttaccgcct gcgtcattac ccagggccac attcttggcc aattgcaagc 26040 catcaacaaa gcccgccaag agtttctgct acgaaaggga cggggggttt acttggaccc 26100 ccagtccggc gaggagctca acccaatccc cccgccgccg cagccctatc agcagcagcc 26160 gcgggccctt gcttcccagg atggcaccca aaaagaagct gcagctgccg ccgccaccca 26220 cggacgagga ggaatactgg gacagtcagg cagaggaggt tttggacgag gaggaggagg 26280 acatgatgga agactgggag agcctagacg aggaagcttc cgaggtcgaa gaggtgtcag 26340 acgaaacacc gtcaccctcg gtcgcattcc cctcgccggc gccccagaaa tcggcaaccg 26400 gttccagcat ggctacaacc tccgctcctc aggcgccgcc ggcactgccc gttcgccgac 26460 ccaaccgtag atgggacacc actggaacca gggccggtaa gtccaagcag ccgccgccgt 26520 tagcccaaga gcaacaacag cgccaaggct accgctcatg gcgcgggcac aagaacgcca 26580 tagttgcttg cttgcaagac tgtgggggca acatctcctt cgcccgccgc tttcttctct 26640 accatcacgg cgtggccttc ccccgtaaca tcctgcatta ctaccgtcat ctctacagcc 26700 catactgcac cggcggcagc ggcagcggca gcaacagcag cggccacaca gaagcaaagg 26760 cgaccggata gcaagactct gacaaagccc aagaaatcca cagcggcggc agcagcagga 26820 ggaggagcgc tgcgtctggc gcccaacgaa cccgtatcga cccgcgagct tagaaacagg 26880 atttttccca ctctgtatgc tatatttcaa cagagcaggg gccaagaaca agagctgaaa 26940 ataaaaaaca ggtctctgcg atccctcacc cgcagctgcc tgtatcacaa aagcgaagat 27000 cagcttcggc gcacgctgga agacgcggag gctctcttca gtaaatactg cgcgctgact 27060 cttaaggact agtttcgcgc cctttctcaa atttaagcgc gaaaactacg tcatctccag 27120 cggccacacc cggcgccagc acctgtcgtc agcgccattt atgagcaagg aaattcccac 27180 gccctacatg tggagttacc agccacaaat gggacttgcg gctggagctg cccaagacta 27240 ctcaacccga ataaactaca tgagcgcggg accccacatg atatcccggg tcaacggaat 27300 acgcgcccac cgaaaccgaa ttctcctgga acaggcggct attaccacca cacctcgtaa 27360 taaccttaat ccccgtagtt ggcccgctgc cctggtgtac caggaaagtc ccgctcccac 27420 cactgtggta cttcccagag acgcccaggc cgaagttcag atgactaact caggggcgca 27480 gcttgcgggc ggctttcgtc acagggtgcg gtcgcccggg cagggtataa ctcacctgac 27540 aatcagaggg cgaggtattc agctcaacga cgagtcggtg agctcctcgc ttggtctccg 27600 tccggacggg acatttcaga tcggcggcgc cggccgctct tcattcacgc ctcgtcaggc 27660 aatcctaact ctgcagacct cgtcctctga gccgcgctct ggaggcattg gaactctgca 27720 atttattgag gagtttgtgc catcggtcta ctttaacccc ttctcgggac ctcccggcca 27780 ctatccggat caatttattc ctaactttga cgcggtaaag gactcggcgg acggctacga 27840 ctgaatgtta agtggagagg cagagcaact gcgcctgaaa cacctggtcc actgtcgccg 27900 ccacaagtgc tttgcccgcg actccggtga gttttgctac tttgaattgc ccgaggatca 27960 tatcgagggc ccggcgcacg gcgtccggct taccgcccag ggagagcttg cccgtagcct 28020 gattcgggag tttacccagc gccccctgct agttgagcgg gacaggggac cctgtgttct 28080 cactgtgatt tgcaactgtc ctaaccctgg attacatcaa gatctttgtt gccatctctg 28140 tgctgagtat aataaataca gaaattaaaa tatactgggg ctcctatcgc catcctgtaa 28200 acgccaccgt cttcacccgc ccaagcaaac caaggcgaac cttacctggt acttttaaca 28260 tctctccctc tgtgatttac aacagtttca acccagacgg agtgagtcta cgagagaacc 28320 tctccgagct cagctactcc atcagaaaaa acaccaccct ccttacctgc cgggaacgta 28380 cgagtgcgtc accggccgct gcaccacacc taccgcctga ccgtaaacca gactttttcc 28440 ggacagacct caataactct gtttaccaga acaggaggtg agcttagaaa acccttaggg 28500 tattaggcca aaggcgcagc tactgtgggg tttatgaaca attcaagcaa ctctacgggc 28560 tattctaatt caggtttctc tagaatcggg gttggggtta ttctctgtct tgtgattctc 28620 tttattctta tactaacgct tctctgccta aggctcgccg cctgctgtgt gcacatttgc 28680 atttattgtc agctttttaa acgctggggt cgccacccaa gatgattagg tacataatcc 28740 taggtttact cacccttgcg tcagcccacg gtaccaccca aaaggtggat tttaaggagc 28800 cagcctgtaa tgttacattc gcagctgaag ctaatgagtg caccactctt ataaaatgca 28860 ccacagaaca tgaaaagctg cttattcgcc acaaaaacaa aattggcaag tatgctgttt 28920 atgctatttg gcagccaggt gacactacag agtataatgt tacagttttc cagggtaaaa 28980 gtcataaaac ttttatgtat acttttccat tttatgaaat gtgcgacatt accatgtaca 29040 tgagcaaaca gtataagttg tggcccccac aaaattgtgt ggaaaacact ggcactttct 29100 gctgcactgc tatgctaatt acagtgctcg ctttggtctg taccctactc tatattaaat 29160 acaaaagcag acgcagcttt attgaggaaa agaaaatgcc ttaatttact aagttacaaa 29220 gctaatgtca ccactaactg ctttactcgc tgcttgcaaa acaaattcaa aaagttagca 29280 ttataattag aataggattt aaaccccccg gtcatttcct gctcaatacc attcccctga 29340 acaattgact ctatgtggga tatgctccag cgctacaacc ttgaagtcag gcttcctgga 29400 tgtcagcatc tgactttggc cagcacctgt cccgcggatt tgttccagtc caactacagc 29460 gacccaccct aacagagatg accaacacaa ccaacgcggc cgccgctacc ggacttacat 29520 ctaccacaaa tacaccccaa gtttctgcct ttgtcaataa ctgggataac ttgggcatgt 29580 ggtggttctc catagcgctt atgtttgtat gccttattat tatgtggctc atctgctgcc 29640 taaagcgcaa acgcgcccga ccacccatct atagtcccat cattgtgcta cacccaaaca 29700 atgatggaat ccatagattg gacggactga aacacatgtt cttttctctt acagtatgat 29760 taaatgagac atgattcctc gagtttttat attactgacc cttgttgcgc ttttttgtgc 29820 gtgctccaca ttggctgcgg tttctcacat cgaagtagac tgcattccag ccttcacagt 29880 ctatttgctt tacggatttg tcaccctcac gctcatctgc agcctcatca ctgtggtcat 29940 cgcctttatc cagtgcattg actgggtctg tgtgcgcttt gcatatctca gacaccatcc 30000 ccagtacagg gacaggacta tagctgagct tcttagaatt ctttaattat gaaatttact 30060 gtgacttttc tgctgattat ttgcacccta tctgcgtttt gttccccgac ctccaagcct 30120 caaagacata tatcatgcag attcactcgt atatggaata ttccaagttg ctacaatgaa 30180 aaaagcgatc tttccgaagc ctggttatat gcaatcatct ctgttatggt gttctgcagt 30240 accatcttag ccctagctat atatccctac cttgacattg gctggaacgc aatagatgcc 30300 atgaaccacc caactttccc cgcgcccgct atgcttccac tgcaacaagt tgttgccggc 30360 ggctttgtcc cagccaatca gcctcgccca ccttctccca cccccactga aatcagctac 30420 tttaatctaa caggaggaga tgactgacac cctagatcta gaaatggacg gaattattac 30480 agagcagcgc ctgctagaaa gacgcagggc agcggccgag caacagcgca tgaatcaaga 30540 gctccaagac atggttaact tgcaccagtg caaaaggggt atcttttgtc tggtaaagca 30600 ggccaaagtc acctacgaca gtaataccac cggacaccgc cttagctaca agttgccaac 30660 caagcgtcag aaattggtgg tcatggtggg agaaaagccc attaccataa ctcagcactc 30720 ggtagaaacc gaaggctgca ttcactcacc ttgtcaagga cctgaggatc tctgcaccct 30780 tattaagacc ctgtgcggtc tcaaagatct tattcccttt aactaataaa aaaaaataat 30840 aaagcatcac ttacttaaaa tcagttagca aatttctgtc cagtttattc agcagcacct 30900 ccttgccctc ctcccagctc tggtattgca gcttcctcct ggctgcaaac tttctccaca 30960 atctaaatgg aatgtcagtt tcctcctgtt cctgtccatc cgcacccact atcttcatgt 31020 tgttgcagat gaagcgcgca agaccgtctg aagatacctt caaccccgtg tatccatatg 31080 acacggaaac cggtcctcca actgtgcctt ttcttactcc tccctttgta tcccccaatg 31140 ggtttcaaga gagtccccct ggggtactct ctttgcgcct atccgaacct ctagttacct 31200 ccaatggcat gcttgcgctc aaaatgggca acggcctctc tctggacgag gccggcaacc 31260 ttacctccca aaatgtaacc actgtgagcc cacctctcaa aaaaaccaag tcaaacataa 31320 acctggaaat atctgcaccc ctcacagtta cctcagaagc cctaactgtg gctgccgccg 31380 cacctctaat ggtcgcgggc aacacactca ccatgcaatc acaggccccg ctaaccgtgc 31440 acgactccaa acttagcatt gccacccaag gacccctcac agtgtcagaa ggaaagctag 31500 ccctgcaaac atcaggcccc ctcaccacca ccgatagcag tacccttact atcactgcct 31560 caccccctct aactactgcc actggtagct tgggcattga cttgaaagag cccatttata 31620 cacaaaatgg aaaactagga ctaaagtacg gggctccttt gcatgtaaca gacgacctaa 31680 acactttgac cgtagcaact ggtccaggtg tgactattaa taatacttcc ttgcaaacta 31740 aagttactgg agccttgggt tttgattcac aaggcaatat gcaacttaat gtagcaggag 31800 gactaaggat tgattctcaa aacagacgcc ttatacttga tgttagttat ccgtttgatg 31860 ctcaaaacca actaaatcta agactaggac agggccctct ttttataaac tcagcccaca 31920 acttggatat taactacaac aaaggccttt acttgtttac agcttcaaac aattccaaaa 31980 agcttgaggt taacctaagc actgccaagg ggttgatgtt tgacgctaca gccatagcca 32040 ttaatgcagg agatgggctt gaatttggtt cacctaatgc accaaacaca aatcccctca 32100 aaacaaaaat tggccatggc ctagaatttg attcaaacaa ggctatggtt cctaaactag 32160 gaactggcct tagttttgac agcacaggtg ccattacagt aggaaacaaa aataatgata 32220 agctaacttt gtggaccaca ccagctccat ctcctaactg tagactaaat gcagagaaag 32280 atgctaaact cactttggtc ttaacaaaat gtggcagtca aatacttgct acagtttcag 32340 ttttggctgt taaaggcagt ttggctccaa tatctggaac agttcaaagt gctcatctta 32400 ttataagatt tgacgaaaat ggagtgctac taaacaattc cttcctggac ccagaatatt 32460 ggaactttag aaatggagat cttactgaag gcacagccta tacaaacgct gttggattta 32520 tgcctaacct atcagcttat ccaaaatctc acggtaaaac tgccaaaagt aacattgtca 32580 gtcaagttta cttaaacgga gacaaaacta aacctgtaac actaaccatt acactaaacg 32640 gtacacagga aacaggagac acaactgaga tgtggcatga aggcctagaa gaggcctctc 32700 gcttgtactt tggggagagg aacgtcaaag gcatgtttga ggtgctggag cccctgcatg 32760 ctatgatgga acgcggtccc cagaccctga aggaaacgtc ctttaatcag gcatatggtc 32820 gagatttaat ggaggcacaa gaatggtgcc gaaagtacat gaaatcaggg aacgtcaagg 32880 acctcctcca agcctgggac ctctactatc acgtgttcag acgaatctca aagcagccaa 32940 gtgcatactc tatgtcattt tcatgggact ggtctggcca caactacatt aatgaaatat 33000 ttgccacatc ctcttacact ttttcataca ttgcccaaga ataaagaatc gtttgtgtta 33060 tgtttcaacg tgtttatttt tcaattgcag aaaatttcga atcatttttc attcagtagt 33120 atagccccac caccacatag cttatacaga tcaccgtacc ttaatcaaac ctacatgggg 33180 gtagagtcat aatcgtgcat caggataggg cggtggtgct gcagcagcgc gcgaataaac 33240 tgctgccgcc gccgctccgt cctgcaggaa tacaacatgg cagtggtctc ctcagcgatg 33300 attcgcaccg cccgcagcat aaggcgcctt gtcctccggg cacagcagcg caccctgatc 33360 tcacttaaat cagcacagta actgcagcac agcaccacaa tattgttcaa aatcccacag 33420 tgcaaggcgc tgtatccaaa gctcatggcg gggaccacag aacccacgtg gccatcatac 33480 cacaagcgca ggtagattaa gtggcgaccc ctcataaaca cgctggacat aaacattacc 33540 tcttttggca tgttgtaatt caccacctcc cggtaccata taaacctctg attaaacatg 33600 gcgccatcca ccaccatcct aaaccagctg gccaaaacct gcccgccggc tatacactgc 33660 agggaaccgg gactggaaca atgacagtgg agagcccagg actcgtaacc atggatcatc 33720 atgctcgtca tgatatcaat gttggcacaa cacaggcaca cgtgcataca cttcctcagg 33780 attacaagct cctcccgcgt tagaaccata tcccagggaa caacccattc ctgaatcagc 33840 gtaaatccca cactgcaggg aagacctcgc acgtaactca cgttgtgcat tgtcaaagtg 33900 ttacattcgg gcagcagcgg atgatcctcc agtatggtag cgcgggtttc tgtctcaaaa 33960 ggaggtagac gatccctact gtacggagtg cgccgagaca accgagatcg tgttggtcgt 34020 agtgtcatgc caaatggaac gccggacgta gtcatatttc ctgaagcaaa accaggtgcg 34080 ggcgtgacaa acagatctgc gtctccggtc tcgccgctta gatcgctctg tgtagtagtt 34140 gtagtatatc cactctctca aagcatccag gcgccccctg gcttcgggtt ctatgtaaac 34200 tccttcatgc gccgctgccc tgataacatc caccaccgca gaataagcca cacccagcca 34260 acctacacat tcgttctgcg agtcacacac gggaggagcg ggaagagctg gaagaaccat 34320 gttttttttt ttattccaaa agattatcca aaacctcaaa atgaagatct attaagtgaa 34380 cgcgctcccc tccggtggcg tggtcaaact ctacagccaa agaacagata atggcatttg 34440 taagatgttg cacaatggct tccaaaaggc aaacggccct cacgtccaag tggacgtaaa 34500 ggctaaaccc ttcagggtga atctcctcta taaacattcc agcaccttca accatgccca 34560 aataattctc atctcgccac cttctcaata tatctctaag caaatcccga atattaagtc 34620 cggccattgt aaaaatctgc tccagagcgc cctccacctt cagcctcaag cagcgaatca 34680 tgattgcaaa aattcaggtt cctcacagac ctgtataaga ttcaaaagcg gaacattaac 34740 aaaaataccg cgatcccgta ggtcccttcg cagggccagc tgaacataat cgtgcaggtc 34800 tgcacggacc agcgcggcca cttccccgcc aggaaccatg acaaaagaac ccacactgat 34860 tatgacacgc atactcggag ctatgctaac cagcgtagcc ccgatgtaag cttgttgcat 34920 gggcggcgat ataaaatgca aggtgctgct caaaaaatca ggcaaagcct cgcgcaaaaa 34980 agaaagcaca tcgtagtcat gctcatgcag ataaaggcag gtaagctccg gaaccaccac 35040 agaaaaagac accatttttc tctcaaacat gtctgcgggt ttctgcataa acacaaaata 35100 aaataacaaa aaaacattta aacattagaa gcctgtctta caacaggaaa aacaaccctt 35160 ataagcataa gacggactac ggccatgccg gcgtgaccgt aaaaaaactg gtcaccgtga 35220 ttaaaaagca ccaccgacag ctcctcggtc atgtccggag tcataatgta agactcggta 35280 aacacatcag gttgattcac atcggtcagt gctaaaaagc gaccgaaata gcccggggga 35340 atacataccc gcaggcgtag agacaacatt acagccccca taggaggtat aacaaaatta 35400 ataggagaga aaaacacata aacacctgaa aaaccctcct gcctaggcaa aatagcaccc 35460 tcccgctcca gaacaacata cagcgcttcc acagcggcag ccataacagt cagccttacc 35520 agtaaaaaag aaaacctatt aaaaaaacac cactcgacac ggcaccagct caatcagtca 35580 cagtgtaaaa aagggccaag tgcagagcga gtatatatag gactaaaaaa tgacgtaacg 35640 gttaaagtcc acaaaaaaca cccagaaaac cgcacgcgaa cctacgccca gaaacgaaag 35700 ccaaaaaacc cacaacttcc tcaaatcgtc acttccgttt tcccacgtta cgtcacttcc 35760 cattttaaga aaactacaat tcccaacaca tacaagttac tccgccctaa aacctacgtc 35820 acccgccccg ttcccacgcc ccgcgccacg tcacaaactc caccccctca ttatcatatt 35880 ggcttcaatc caaaataagg tatattattg atgatg 35916 <210> 32 <211> 289 <212> PRT <213> Human adenovirus type 5 <400> 32 Met Arg His Ile Ile Cys His Gly Gly Val Ile Thr Glu Glu Met Ala 1 5 10 15 Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val Leu Ala Asp Asn Leu 20 25 30 Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu His Glu Leu Tyr Asp 35 40 45 Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu Glu Ala Val Ser Gln 50 55 60 Ile Phe Pro Asp Ser Val Met Leu Ala Val Gln Glu Gly Ile Asp Leu 65 70 75 80 Leu Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu Pro Pro His Leu Ser 85 90 95 Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu Gly Pro Val Ser Met 100 105 110 Pro Asn Leu Val Pro Glu Val Ile Asp Leu Thr Cys His Glu Ala Gly 115 120 125 Phe Pro Pro Ser Asp Asp Glu Asp Glu Glu Gly Glu Glu Phe Val Leu 130 135 140 Asp Tyr Val Glu His Pro Gly His Gly Cys Arg Ser Cys His Tyr His 145 150 155 160 Arg Arg Asn Thr Gly Asp Pro Asp Ile Met Cys Ser Leu Cys Tyr Met 165 170 175 Arg Thr Cys Gly Met Phe Val Tyr Ser Pro Val Ser Glu Pro Glu Pro 180 185 190 Glu Pro Glu Pro Glu Pro Glu Pro Ala Arg Pro Thr Arg Arg Pro Lys 195 200 205 Met Ala Pro Ala Ile Leu Arg Arg Pro Thr Ser Pro Val Ser Arg Glu 210 215 220 Cys Asn Ser Ser Thr Asp Ser Cys Asp Ser Gly Pro Ser Asn Thr Pro 225 230 235 240 Pro Glu Ile His Pro Val Val Pro Leu Cys Pro Ile Lys Pro Val Ala 245 250 255 Val Arg Val Gly Gly Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu 260 265 270 Leu Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg 275 280 285 Pro <210> 33 <211> 284 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 33 Met Arg His Ile Ile Cys His Gly Gly Val Ile Thr Glu Glu Met Ala 1 5 10 15 Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val Leu Ala Asp Asn Leu 20 25 30 Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu His Glu Leu Tyr Asp 35 40 45 Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu Glu Ala Val Ser Gln 50 55 60 Ile Phe Pro Asp Ser Val Met Leu Ala Val Gln Glu Gly Ile Asp Leu 65 70 75 80 Leu Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu Pro Pro His Leu Ser 85 90 95 Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu Gly Pro Val Ser Met 100 105 110 Pro Asn Leu Val Pro Glu Val Ile Asp Ala Gly Phe Pro Pro Ser Asp 115 120 125 Asp Glu Asp Glu Glu Gly Glu Glu Phe Val Leu Asp Tyr Val Glu His 130 135 140 Pro Gly His Gly Cys Arg Ser Cys His Tyr His Arg Arg Asn Thr Gly 145 150 155 160 Asp Pro Asp Ile Met Cys Ser Leu Cys Tyr Met Arg Thr Cys Gly Met 165 170 175 Phe Val Tyr Ser Pro Val Ser Glu Pro Glu Pro Glu Pro Glu Pro Glu 180 185 190 Pro Glu Pro Ala Arg Pro Thr Arg Arg Pro Lys Met Ala Pro Ala Ile 195 200 205 Leu Arg Arg Pro Thr Ser Pro Val Ser Arg Glu Cys Asn Ser Ser Thr 210 215 220 Asp Ser Cys Asp Ser Gly Pro Ser Asn Thr Pro Pro Glu Ile His Pro 225 230 235 240 Val Val Pro Leu Cys Pro Ile Lys Pro Val Ala Val Arg Val Gly Gly 245 250 255 Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu Leu Asn Glu Pro Gly 260 265 270 Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg Pro 275 280 <210> 34 <211> 289 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 34 Met Arg His Ile Ile Cys His Gly Gly Val Ile Thr Glu Glu Met Ala 1 5 10 15 Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val Leu Ala Asp Asn Leu 20 25 30 Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu His Glu Leu Tyr Asp 35 40 45 Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu Glu Ala Val Ser Gln 50 55 60 Ile Phe Pro Asp Ser Val Met Leu Ala Val Gln Glu Gly Ile Asp Leu 65 70 75 80 Leu Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu Pro Pro His Leu Ser 85 90 95 Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu Gly Pro Val Ser Met 100 105 110 Pro Asn Leu Val Pro Glu Val Ile Asp Leu Thr Gly His Glu Ala Gly 115 120 125 Phe Pro Pro Ser Asp Asp Glu Asp Glu Glu Gly Glu Glu Phe Val Leu 130 135 140 Asp Tyr Val Glu His Pro Gly His Gly Cys Arg Ser Cys His Tyr His 145 150 155 160 Arg Arg Asn Thr Gly Asp Pro Asp Ile Met Cys Ser Leu Cys Tyr Met 165 170 175 Arg Thr Cys Gly Met Phe Val Tyr Ser Pro Val Ser Glu Pro Glu Pro 180 185 190 Glu Pro Glu Pro Glu Pro Glu Pro Ala Arg Pro Thr Arg Arg Pro Lys 195 200 205 Met Ala Pro Ala Ile Leu Arg Arg Pro Thr Ser Pro Val Ser Arg Glu 210 215 220 Cys Asn Ser Ser Thr Asp Ser Cys Asp Ser Gly Pro Ser Asn Thr Pro 225 230 235 240 Pro Glu Ile His Pro Val Val Pro Leu Cys Pro Ile Lys Pro Val Ala 245 250 255 Val Arg Val Gly Gly Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu 260 265 270 Leu Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg 275 280 285 Pro <210> 35 <211> 278 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 35 Met Glu Glu Met Ala Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val 1 5 10 15 Leu Ala Asp Asn Leu Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu 20 25 30 His Glu Leu Tyr Asp Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu 35 40 45 Glu Ala Val Ser Gln Ile Phe Pro Asp Ser Val Met Leu Ala Val Gln 50 55 60 Glu Gly Ile Asp Leu Leu Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu 65 70 75 80 Pro Pro His Leu Ser Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu 85 90 95 Gly Pro Val Ser Met Pro Asn Leu Val Pro Glu Val Ile Asp Leu Thr 100 105 110 Cys His Glu Ala Gly Phe Pro Pro Ser Asp Asp Glu Asp Glu Glu Gly 115 120 125 Glu Glu Phe Val Leu Asp Tyr Val Glu His Pro Gly His Gly Cys Arg 130 135 140 Ser Cys His Tyr His Arg Arg Asn Thr Gly Asp Pro Asp Ile Met Cys 145 150 155 160 Ser Leu Cys Tyr Met Arg Thr Cys Gly Met Phe Val Tyr Ser Pro Val 165 170 175 Ser Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Ala Arg Pro 180 185 190 Thr Arg Arg Pro Lys Met Ala Pro Ala Ile Leu Arg Arg Pro Thr Ser 195 200 205 Pro Val Ser Arg Glu Cys Asn Ser Ser Thr Asp Ser Cys Asp Ser Gly 210 215 220 Pro Ser Asn Thr Pro Pro Glu Ile His Pro Val Val Pro Leu Cys Pro 225 230 235 240 Ile Lys Pro Val Ala Val Arg Val Gly Gly Arg Arg Gln Ala Val Glu 245 250 255 Cys Ile Glu Asp Leu Leu Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser 260 265 270 Cys Lys Arg Pro Arg Pro 275 <210> 36 <211> 289 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 36 Met Arg His Ile Ile Cys His Gly Gly Val Ile Thr Glu Glu Met Ala 1 5 10 15 Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val Leu Ala Asp Asn Leu 20 25 30 Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu His Glu Leu His Asp 35 40 45 Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu Glu Ala Val Ser Gln 50 55 60 Ile Phe Pro Asp Ser Val Met Leu Ala Val Gln Glu Gly Ile Asp Leu 65 70 75 80 Leu Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu Pro Pro His Leu Ser 85 90 95 Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu Gly Pro Val Ser Met 100 105 110 Pro Asn Leu Val Pro Glu Val Ile Asp Leu Thr Gly His Glu Ala Gly 115 120 125 Phe Pro Pro Ser Asp Asp Glu Asp Glu Glu Gly Glu Glu Phe Val Leu 130 135 140 Asp Tyr Val Glu His Pro Gly His Gly Cys Arg Ser Cys His Tyr His 145 150 155 160 Arg Arg Asn Thr Gly Asp Pro Asp Ile Met Cys Ser Leu Cys Tyr Met 165 170 175 Arg Thr Cys Gly Met Phe Val Tyr Ser Pro Val Ser Glu Pro Glu Pro 180 185 190 Glu Pro Glu Pro Glu Pro Glu Pro Ala Arg Pro Thr Arg Arg Pro Lys 195 200 205 Met Ala Pro Ala Ile Leu Arg Arg Pro Thr Ser Pro Val Ser Arg Glu 210 215 220 Cys Asn Ser Ser Thr Asp Ser Cys Asp Ser Gly Pro Ser Asn Thr Pro 225 230 235 240 Pro Glu Ile His Pro Val Val Pro Leu Cys Pro Ile Lys Pro Val Ala 245 250 255 Val Arg Val Gly Gly Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu 260 265 270 Leu Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg 275 280 285 Pro <210> 37 <211> 278 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 37 Met Glu Glu Met Ala Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val 1 5 10 15 Leu Ala Asp Asn Leu Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu 20 25 30 His Glu Leu His Asp Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu 35 40 45 Glu Ala Val Ser Gln Ile Phe Pro Asp Ser Val Met Leu Ala Val Gln 50 55 60 Glu Gly Ile Asp Leu Leu Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu 65 70 75 80 Pro Pro His Leu Ser Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu 85 90 95 Gly Pro Val Ser Met Pro Asn Leu Val Pro Glu Val Ile Asp Leu Thr 100 105 110 Gly His Glu Ala Gly Phe Pro Pro Ser Asp Asp Glu Asp Glu Glu Gly 115 120 125 Glu Glu Phe Val Leu Asp Tyr Val Glu His Pro Gly His Gly Cys Arg 130 135 140 Ser Cys His Tyr His Arg Arg Asn Thr Gly Asp Pro Asp Ile Met Cys 145 150 155 160 Ser Leu Cys Tyr Met Arg Thr Cys Gly Met Phe Val Tyr Ser Pro Val 165 170 175 Ser Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Ala Arg Pro 180 185 190 Thr Arg Arg Pro Lys Met Ala Pro Ala Ile Leu Arg Arg Pro Thr Ser 195 200 205 Pro Val Ser Arg Glu Cys Asn Ser Ser Thr Asp Ser Cys Asp Ser Gly 210 215 220 Pro Ser Asn Thr Pro Pro Glu Ile His Pro Val Val Pro Leu Cys Pro 225 230 235 240 Ile Lys Pro Val Ala Val Arg Val Gly Gly Arg Arg Gln Ala Val Glu 245 250 255 Cys Ile Glu Asp Leu Leu Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser 260 265 270 Cys Lys Arg Pro Arg Pro 275 <210> 38 <211> 128 <212> PRT <213> Human adenovirus type 5 <400> 38 Met Ala Ala Ala Val Glu Ala Leu Tyr Val Val Leu Glu Arg Glu Gly 1 5 10 15 Ala Ile Leu Pro Arg Gln Glu Gly Phe Ser Gly Val Tyr Val Phe Phe 20 25 30 Ser Pro Ile Asn Phe Val Ile Pro Pro Met Gly Ala Val Met Leu Ser 35 40 45 Leu Arg Leu Arg Val Cys Ile Pro Pro Gly Tyr Phe Gly Arg Phe Leu 50 55 60 Ala Leu Thr Asp Val Asn Gln Pro Asp Val Phe Thr Glu Ser Tyr Ile 65 70 75 80 Met Thr Pro Asp Met Thr Glu Glu Leu Ser Val Val Leu Phe Asn His 85 90 95 Gly Asp Gln Phe Phe Tyr Gly His Ala Gly Met Ala Val Val Arg Leu 100 105 110 Met Leu Ile Arg Val Val Phe Pro Val Val Arg Gln Ala Ser Asn Val 115 120 125 <210> 39 <211> 125 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 39 Met Ala Ala Ala Val Glu Ala Leu Tyr Val Val Leu Glu Arg Glu Gly 1 5 10 15 Ala Ile Leu Pro Arg Gln Glu Gly Phe Ser Gly Val Tyr Val Phe Phe 20 25 30 Ser Pro Ile Asn Phe Val Ile Pro Pro Met Gly Ala Val Met Leu Ser 35 40 45 Leu Arg Leu Arg Val Cys Ile Pro Pro Gly Tyr Phe Gly Arg Phe Leu 50 55 60 Ala Leu Thr Asp Val Asn Gln Pro Asp Val Phe Thr Glu Ser Tyr Ile 65 70 75 80 Met Thr Pro Asp Met Thr Glu Glu Leu Ser Val Val Leu Phe Asn His 85 90 95 Gly Asp Gln Phe Phe Tyr Gly His Ala Gly Met Ala Val Val Arg Leu 100 105 110 Met Leu Ile Arg Val Val Phe Pro Val Val Arg Gln Ala 115 120 125 <210> 40 <211> 150 <212> PRT <213> Human adenovirus type 5 <400> 40 Met Thr Thr Ser Gly Val Pro Phe Gly Met Thr Leu Arg Pro Thr Arg 1 5 10 15 Ser Arg Leu Ser Arg Arg Thr Pro Tyr Ser Arg Asp Arg Leu Pro Pro 20 25 30 Phe Glu Thr Glu Thr Arg Ala Thr Ile Leu Glu Asp His Pro Leu Leu 35 40 45 Pro Glu Cys Asn Thr Leu Thr Met His Asn Ala Trp Thr Ser Pro Ser 50 55 60 Pro Pro Val Lys Gln Pro Gln Val Gly Gln Gln Pro Val Ala Gln Gln 65 70 75 80 Leu Asp Ser Asp Met Asn Leu Ser Glu Leu Pro Gly Glu Phe Ile Asn 85 90 95 Ile Thr Asp Glu Arg Leu Ala Arg Gln Glu Thr Val Trp Asn Ile Thr 100 105 110 Pro Lys Asn Met Ser Val Thr His Asp Met Met Leu Phe Lys Ala Ser 115 120 125 Arg Gly Glu Arg Thr Val Tyr Ser Val Cys Trp Glu Gly Gly Gly Arg 130 135 140 Leu Asn Thr Arg Val Leu 145 150 <210> 41 <211> 581 <212> PRT <213> Human adenovirus type 5 <400> 41 Met Lys Arg Ala Arg Pro Ser Glu Asp Thr Phe Asn Pro Val Tyr Pro 1 5 10 15 Tyr Asp Thr Glu Thr Gly Pro Pro Thr Val Pro Phe Leu Thr Pro Pro 20 25 30 Phe Val Ser Pro Asn Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45 Leu Arg Leu Ser Glu Pro Leu Val Thr Ser Asn Gly Met Leu Ala Leu 50 55 60 Lys Met Gly Asn Gly Leu Ser Leu Asp Glu Ala Gly Asn Leu Thr Ser 65 70 75 80 Gln Asn Val Thr Thr Val Ser Pro Pro Leu Lys Lys Thr Lys Ser Asn 85 90 95 Ile Asn Leu Glu Ile Ser Ala Pro Leu Thr Val Thr Ser Glu Ala Leu 100 105 110 Thr Val Ala Ala Ala Ala Pro Leu Met Val Ala Gly Asn Thr Leu Thr 115 120 125 Met Gln Ser Gln Ala Pro Leu Thr Val His Asp Ser Lys Leu Ser Ile 130 135 140 Ala Thr Gln Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu Gln 145 150 155 160 Thr Ser Gly Pro Leu Thr Thr Thr Asp Ser Ser Thr Leu Thr Ile Thr 165 170 175 Ala Ser Pro Pro Leu Thr Thr Ala Thr Gly Ser Leu Gly Ile Asp Leu 180 185 190 Lys Glu Pro Ile Tyr Thr Gln Asn Gly Lys Leu Gly Leu Lys Tyr Gly 195 200 205 Ala Pro Leu His Val Thr Asp Asp Leu Asn Thr Leu Thr Val Ala Thr 210 215 220 Gly Pro Gly Val Thr Ile Asn Asn Thr Ser Leu Gln Thr Lys Val Thr 225 230 235 240 Gly Ala Leu Gly Phe Asp Ser Gln Gly Asn Met Gln Leu Asn Val Ala 245 250 255 Gly Gly Leu Arg Ile Asp Ser Gln Asn Arg Arg Leu Ile Leu Asp Val 260 265 270 Ser Tyr Pro Phe Asp Ala Gln Asn Gln Leu Asn Leu Arg Leu Gly Gln 275 280 285 Gly Pro Leu Phe Ile Asn Ser Ala His Asn Leu Asp Ile Asn Tyr Asn 290 295 300 Lys Gly Leu Tyr Leu Phe Thr Ala Ser Asn Asn Ser Lys Lys Leu Glu 305 310 315 320 Val Asn Leu Ser Thr Ala Lys Gly Leu Met Phe Asp Ala Thr Ala Ile 325 330 335 Ala Ile Asn Ala Gly Asp Gly Leu Glu Phe Gly Ser Pro Asn Ala Pro 340 345 350 Asn Thr Asn Pro Leu Lys Thr Lys Ile Gly His Gly Leu Glu Phe Asp 355 360 365 Ser Asn Lys Ala Met Val Pro Lys Leu Gly Thr Gly Leu Ser Phe Asp 370 375 380 Ser Thr Gly Ala Ile Thr Val Gly Asn Lys Asn Asn Asp Lys Leu Thr 385 390 395 400 Leu Trp Thr Thr Pro Ala Pro Ser Pro Asn Cys Arg Leu Asn Ala Glu 405 410 415 Lys Asp Ala Lys Leu Thr Leu Val Leu Thr Lys Cys Gly Ser Gln Ile 420 425 430 Leu Ala Thr Val Ser Val Leu Ala Val Lys Gly Ser Leu Ala Pro Ile 435 440 445 Ser Gly Thr Val Gln Ser Ala His Leu Ile Ile Arg Phe Asp Glu Asn 450 455 460 Gly Val Leu Leu Asn Asn Ser Phe Leu Asp Pro Glu Tyr Trp Asn Phe 465 470 475 480 Arg Asn Gly Asp Leu Thr Glu Gly Thr Ala Tyr Thr Asn Ala Val Gly 485 490 495 Phe Met Pro Asn Leu Ser Ala Tyr Pro Lys Ser His Gly Lys Thr Ala 500 505 510 Lys Ser Asn Ile Val Ser Gln Val Tyr Leu Asn Gly Asp Lys Thr Lys 515 520 525 Pro Val Thr Leu Thr Ile Thr Leu Asn Gly Thr Gln Glu Thr Gly Asp 530 535 540 Thr Thr Pro Ser Ala Tyr Ser Met Ser Phe Ser Trp Asp Trp Ser Gly 545 550 555 560 His Asn Tyr Ile Asn Glu Ile Phe Ala Thr Ser Ser Tyr Thr Phe Ser 565 570 575 Tyr Ile Ala Gln Glu 580 <210> 42 <211> 671 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 42 Met Lys Arg Ala Arg Pro Ser Glu Asp Thr Phe Asn Pro Val Tyr Pro 1 5 10 15 Tyr Asp Thr Glu Thr Gly Pro Pro Thr Val Pro Phe Leu Thr Pro Pro 20 25 30 Phe Val Ser Pro Asn Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45 Leu Arg Leu Ser Glu Pro Leu Val Thr Ser Asn Gly Met Leu Ala Leu 50 55 60 Lys Met Gly Asn Gly Leu Ser Leu Asp Glu Ala Gly Asn Leu Thr Ser 65 70 75 80 Gln Asn Val Thr Thr Val Ser Pro Pro Leu Lys Lys Thr Lys Ser Asn 85 90 95 Ile Asn Leu Glu Ile Ser Ala Pro Leu Thr Val Thr Ser Glu Ala Leu 100 105 110 Thr Val Ala Ala Ala Ala Pro Leu Met Val Ala Gly Asn Thr Leu Thr 115 120 125 Met Gln Ser Gln Ala Pro Leu Thr Val His Asp Ser Lys Leu Ser Ile 130 135 140 Ala Thr Gln Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu Gln 145 150 155 160 Thr Ser Gly Pro Leu Thr Thr Thr Asp Ser Ser Thr Leu Thr Ile Thr 165 170 175 Ala Ser Pro Pro Leu Thr Thr Ala Thr Gly Ser Leu Gly Ile Asp Leu 180 185 190 Lys Glu Pro Ile Tyr Thr Gln Asn Gly Lys Leu Gly Leu Lys Tyr Gly 195 200 205 Ala Pro Leu His Val Thr Asp Asp Leu Asn Thr Leu Thr Val Ala Thr 210 215 220 Gly Pro Gly Val Thr Ile Asn Asn Thr Ser Leu Gln Thr Lys Val Thr 225 230 235 240 Gly Ala Leu Gly Phe Asp Ser Gln Gly Asn Met Gln Leu Asn Val Ala 245 250 255 Gly Gly Leu Arg Ile Asp Ser Gln Asn Arg Arg Leu Ile Leu Asp Val 260 265 270 Ser Tyr Pro Phe Asp Ala Gln Asn Gln Leu Asn Leu Arg Leu Gly Gln 275 280 285 Gly Pro Leu Phe Ile Asn Ser Ala His Asn Leu Asp Ile Asn Tyr Asn 290 295 300 Lys Gly Leu Tyr Leu Phe Thr Ala Ser Asn Asn Ser Lys Lys Leu Glu 305 310 315 320 Val Asn Leu Ser Thr Ala Lys Gly Leu Met Phe Asp Ala Thr Ala Ile 325 330 335 Ala Ile Asn Ala Gly Asp Gly Leu Glu Phe Gly Ser Pro Asn Ala Pro 340 345 350 Asn Thr Asn Pro Leu Lys Thr Lys Ile Gly His Gly Leu Glu Phe Asp 355 360 365 Ser Asn Lys Ala Met Val Pro Lys Leu Gly Thr Gly Leu Ser Phe Asp 370 375 380 Ser Thr Gly Ala Ile Thr Val Gly Asn Lys Asn Asn Asp Lys Leu Thr 385 390 395 400 Leu Trp Thr Thr Pro Ala Pro Ser Pro Asn Cys Arg Leu Asn Ala Glu 405 410 415 Lys Asp Ala Lys Leu Thr Leu Val Leu Thr Lys Cys Gly Ser Gln Ile 420 425 430 Leu Ala Thr Val Ser Val Leu Ala Val Lys Gly Ser Leu Ala Pro Ile 435 440 445 Ser Gly Thr Val Gln Ser Ala His Leu Ile Ile Arg Phe Asp Glu Asn 450 455 460 Gly Val Leu Leu Asn Asn Ser Phe Leu Asp Pro Glu Tyr Trp Asn Phe 465 470 475 480 Arg Asn Gly Asp Leu Thr Glu Gly Thr Ala Tyr Thr Asn Ala Val Gly 485 490 495 Phe Met Pro Asn Leu Ser Ala Tyr Pro Lys Ser His Gly Lys Thr Ala 500 505 510 Lys Ser Asn Ile Val Ser Gln Val Tyr Leu Asn Gly Asp Lys Thr Lys 515 520 525 Pro Val Thr Leu Thr Ile Thr Leu Asn Gly Thr Gln Glu Thr Gly Asp 530 535 540 Thr Thr Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr 545 550 555 560 Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu 565 570 575 His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe 580 585 590 Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg 595 600 605 Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Thr Gln Ala Trp Asp 610 615 620 Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Gln Pro Ser Ala Tyr 625 630 635 640 Ser Met Ser Phe Ser Trp Asp Trp Ser Gly His Asn Tyr Ile Asn Glu 645 650 655 Ile Phe Ala Thr Ser Ser Tyr Thr Phe Ser Tyr Ile Ala Gln Glu 660 665 670 <210> 43 <211> 671 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 43 Met Lys Arg Ala Arg Pro Ser Glu Asp Thr Phe Asn Pro Val Tyr Pro 1 5 10 15 Tyr Asp Thr Glu Thr Gly Pro Pro Thr Val Pro Phe Leu Thr Pro Pro 20 25 30 Phe Val Ser Pro Asn Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 35 40 45 Leu Arg Leu Ser Glu Pro Leu Val Thr Ser Asn Gly Met Leu Ala Leu 50 55 60 Lys Met Gly Asn Gly Leu Ser Leu Asp Glu Ala Gly Asn Leu Thr Ser 65 70 75 80 Gln Asn Val Thr Thr Val Ser Pro Pro Leu Lys Lys Thr Lys Ser Asn 85 90 95 Ile Asn Leu Glu Ile Ser Ala Pro Leu Thr Val Thr Ser Glu Ala Leu 100 105 110 Thr Val Ala Ala Ala Ala Pro Leu Met Val Ala Gly Asn Thr Leu Thr 115 120 125 Met Gln Ser Gln Ala Pro Leu Thr Val His Asp Ser Lys Leu Ser Ile 130 135 140 Ala Thr Gln Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu Gln 145 150 155 160 Thr Ser Gly Pro Leu Thr Thr Thr Asp Ser Ser Thr Leu Thr Ile Thr 165 170 175 Ala Ser Pro Pro Leu Thr Thr Ala Thr Gly Ser Leu Gly Ile Asp Leu 180 185 190 Lys Glu Pro Ile Tyr Thr Gln Asn Gly Lys Leu Gly Leu Lys Tyr Gly 195 200 205 Ala Pro Leu His Val Thr Asp Asp Leu Asn Thr Leu Thr Val Ala Thr 210 215 220 Gly Pro Gly Val Thr Ile Asn Asn Thr Ser Leu Gln Thr Lys Val Thr 225 230 235 240 Gly Ala Leu Gly Phe Asp Ser Gln Gly Asn Met Gln Leu Asn Val Ala 245 250 255 Gly Gly Leu Arg Ile Asp Ser Gln Asn Arg Arg Leu Ile Leu Asp Val 260 265 270 Ser Tyr Pro Phe Asp Ala Gln Asn Gln Leu Asn Leu Arg Leu Gly Gln 275 280 285 Gly Pro Leu Phe Ile Asn Ser Ala His Asn Leu Asp Ile Asn Tyr Asn 290 295 300 Lys Gly Leu Tyr Leu Phe Thr Ala Ser Asn Asn Ser Lys Lys Leu Glu 305 310 315 320 Val Asn Leu Ser Thr Ala Lys Gly Leu Met Phe Asp Ala Thr Ala Ile 325 330 335 Ala Ile Asn Ala Gly Asp Gly Leu Glu Phe Gly Ser Pro Asn Ala Pro 340 345 350 Asn Thr Asn Pro Leu Lys Thr Lys Ile Gly His Gly Leu Glu Phe Asp 355 360 365 Ser Asn Lys Ala Met Val Pro Lys Leu Gly Thr Gly Leu Ser Phe Asp 370 375 380 Ser Thr Gly Ala Ile Thr Val Gly Asn Lys Asn Asn Asp Lys Leu Thr 385 390 395 400 Leu Trp Thr Thr Pro Ala Pro Ser Pro Asn Cys Arg Leu Asn Ala Glu 405 410 415 Lys Asp Ala Lys Leu Thr Leu Val Leu Thr Lys Cys Gly Ser Gln Ile 420 425 430 Leu Ala Thr Val Ser Val Leu Ala Val Lys Gly Ser Leu Ala Pro Ile 435 440 445 Ser Gly Thr Val Gln Ser Ala His Leu Ile Ile Arg Phe Asp Glu Asn 450 455 460 Gly Val Leu Leu Asn Asn Ser Phe Leu Asp Pro Glu Tyr Trp Asn Phe 465 470 475 480 Arg Asn Gly Asp Leu Thr Glu Gly Thr Ala Tyr Thr Asn Ala Val Gly 485 490 495 Phe Met Pro Asn Leu Ser Ala Tyr Pro Lys Ser His Gly Lys Thr Ala 500 505 510 Lys Ser Asn Ile Val Ser Gln Val Tyr Leu Asn Gly Asp Lys Thr Lys 515 520 525 Pro Val Thr Leu Thr Ile Thr Leu Asn Gly Thr Gln Glu Thr Gly Asp 530 535 540 Thr Thr Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr 545 550 555 560 Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu 565 570 575 His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe 580 585 590 Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg 595 600 605 Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp 610 615 620 Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Gln Pro Ser Ala Tyr 625 630 635 640 Ser Met Ser Phe Ser Trp Asp Trp Ser Gly His Asn Tyr Ile Asn Glu 645 650 655 Ile Phe Ala Thr Ser Ser Tyr Thr Phe Ser Tyr Ile Ala Gln Glu 660 665 670 <210> 44 <211> 238 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 44 Met Ala Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 1 5 10 15 Gly Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser 20 25 30 Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 35 40 45 Val Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 65 70 75 80 Asp Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 85 90 95 Cys Ala Ala Ala Ala Gly Ser Thr Trp Tyr Gly Thr Leu Tyr Glu Tyr 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 115 120 125 Ser Gly Ser Thr Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 130 135 140 Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 145 150 155 160 Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 165 170 175 Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 180 185 190 Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 195 200 205 Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 210 215 220 Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 225 230 235 <210> 45 <211> 952 <212> PRT <213> Human adenovirus type 5 <400> 45 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Glu Thr Tyr Phe Ser Leu Asn Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Pro Cys Glu Trp Asp Glu Ala Ala Thr Ala Leu Glu Ile 130 135 140 Asn Leu Glu Glu Glu Asp Asp Asp Asn Glu Asp Glu Val Asp Glu Gln 145 150 155 160 Ala Glu Gln Gln Lys Thr His Val Phe Gly Gln Ala Pro Tyr Ser Gly 165 170 175 Ile Asn Ile Thr Lys Glu Gly Ile Gln Ile Gly Val Glu Gly Gln Thr 180 185 190 Pro Lys Tyr Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln Ile Gly Glu 195 200 205 Ser Gln Trp Tyr Glu Thr Glu Ile Asn His Ala Ala Gly Arg Val Leu 210 215 220 Lys Lys Thr Thr Pro Met Lys Pro Cys Tyr Gly Ser Tyr Ala Lys Pro 225 230 235 240 Thr Asn Glu Asn Gly Gly Gln Gly Ile Leu Val Lys Gln Gln Asn Gly 245 250 255 Lys Leu Glu Ser Gln Val Glu Met Gln Phe Phe Ser Thr Thr Glu Ala 260 265 270 Thr Ala Gly Asn Gly Asp Asn Leu Thr Pro Lys Val Val Leu Tyr Ser 275 280 285 Glu Asp Val Asp Ile Glu Thr Pro Asp Thr His Ile Ser Tyr Met Pro 290 295 300 Thr Ile Lys Glu Gly Asn Ser Arg Glu Leu Met Gly Gln Gln Ser Met 305 310 315 320 Pro Asn Arg Pro Asn Tyr Ile Ala Phe Arg Asp Asn Phe Ile Gly Leu 325 330 335 Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala 340 345 350 Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu 355 360 365 Ser Tyr Gln Leu Leu Leu Asp Ser Ile Gly Asp Arg Thr Arg Tyr Phe 370 375 380 Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile 385 390 395 400 Ile Glu Asn His Gly Thr Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro 405 410 415 Leu Gly Gly Val Ile Asn Thr Glu Thr Leu Thr Lys Val Lys Pro Lys 420 425 430 Thr Gly Gln Glu Asn Gly Trp Glu Lys Asp Ala Thr Glu Phe Ser Asp 435 440 445 Lys Asn Glu Ile Arg Val Gly Asn Asn Phe Ala Met Glu Ile Asn Leu 450 455 460 Asn Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ser Asn Ile Ala Leu Tyr 465 470 475 480 Leu Pro Asp Lys Leu Lys Tyr Ser Pro Ser Asn Val Lys Ile Ser Asp 485 490 495 Asn Pro Asn Thr Tyr Asp Tyr Met Asn Lys Arg Val Val Ala Pro Gly 500 505 510 Leu Val Asp Cys Tyr Ile Asn Leu Gly Ala Arg Trp Ser Leu Asp Tyr 515 520 525 Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg 530 535 540 Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile 545 550 555 560 Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro 565 570 575 Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val 580 585 590 Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile 595 600 605 Lys Phe Asp Ser Ile Cys Leu Tyr Ala Thr Phe Phe Pro Met Ala His 610 615 620 Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp 625 630 635 640 Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile 645 650 655 Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp 660 665 670 Ala Ala Phe Arg Gly Trp Ala Phe Thr Arg Leu Lys Thr Lys Glu Thr 675 680 685 Pro Ser Leu Gly Ser Gly Tyr Asp Pro Tyr Tyr Thr Tyr Ser Gly Ser 690 695 700 Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys 705 710 715 720 Val Ala Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg 725 730 735 Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu 740 745 750 Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val 755 760 765 Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Ile Pro 770 775 780 Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro 785 790 795 800 Met Ser Arg Gln Val Val Asp Asp Thr Lys Tyr Lys Asp Tyr Gln Gln 805 810 815 Val Gly Ile Leu His Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu 820 825 830 Ala Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala Asn Phe Pro Tyr 835 840 845 Pro Leu Ile Gly Lys Thr Ala Val Asp Ser Ile Thr Gln Lys Lys Phe 850 855 860 Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met 865 870 875 880 Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn 885 890 895 Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu 900 905 910 Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Val Arg Val 915 920 925 His Arg Pro His Arg Gly Val Ile Glu Thr Val Tyr Leu Arg Thr Pro 930 935 940 Phe Ser Ala Gly Asn Ala Thr Thr 945 950 <210> 46 <211> 952 <212> PRT <213> Artificial Sequence <220> <223> Synthetic polypeptide <400> 46 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Glu Thr Tyr Phe Ser Leu Asn Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Pro Cys Glu Trp Asp Glu Ala Ala Thr Ala Leu Glu Ile 130 135 140 Asn Leu Glu Glu Glu Asp Asp Asp Asn Glu Asp Glu Val Asp Glu Gln 145 150 155 160 Ala Glu Gln Gln Lys Thr His Val Phe Gly Gln Ala Pro Tyr Ser Gly 165 170 175 Ile Asn Ile Thr Lys Glu Gly Ile Gln Ile Gly Val Glu Gly Gln Thr 180 185 190 Pro Lys Tyr Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln Ile Gly Glu 195 200 205 Ser Gln Trp Tyr Glu Thr Glu Ile Asn His Ala Ala Gly Arg Val Leu 210 215 220 Lys Lys Thr Thr Pro Met Lys Pro Cys Tyr Gly Ser Tyr Ala Lys Pro 225 230 235 240 Thr Asn Glu Asn Gly Gly Gln Gly Ile Leu Val Lys Gln Gln Asn Gly 245 250 255 Lys Leu Glu Ser Gln Val Glu Met Gln Phe Phe Ser Thr Thr Glu Ala 260 265 270 Thr Ala Gly Asn Gly Asp Asn Leu Thr Pro Lys Val Val Leu Tyr Ser 275 280 285 Glu Asp Val Asp Ile Glu Thr Pro Asp Thr His Ile Ser Tyr Met Pro 290 295 300 Thr Ile Lys Glu Gly Asn Ser Arg Glu Leu Met Gly Gln Gln Ser Met 305 310 315 320 Pro Asn Arg Pro Asn Tyr Ile Ala Phe Arg Asp Asn Phe Ile Gly Leu 325 330 335 Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala 340 345 350 Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu 355 360 365 Ser Tyr Gln Leu Leu Leu Asp Ser Ile Gly Asp Arg Thr Arg Tyr Phe 370 375 380 Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile 385 390 395 400 Ile Glu Asn His Gly Thr Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro 405 410 415 Leu Gly Gly Val Ile Asn Thr Glu Thr Leu Thr Lys Val Lys Pro Lys 420 425 430 Thr Gly Gln Glu Asn Gly Trp Glu Lys Asp Ala Thr Glu Phe Ser Asp 435 440 445 Lys Asn Gln Ile Arg Val Gly Asn Asn Phe Ala Met Glu Ile Asn Leu 450 455 460 Asn Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ser Asn Ile Ala Leu Tyr 465 470 475 480 Leu Pro Asp Lys Leu Lys Tyr Ser Pro Ser Asn Val Lys Ile Ser Asp 485 490 495 Asn Pro Asn Thr Tyr Asp Tyr Met Asn Lys Arg Val Val Ala Pro Gly 500 505 510 Leu Val Asp Cys Tyr Ile Asn Leu Gly Ala Arg Trp Ser Leu Asp Tyr 515 520 525 Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg 530 535 540 Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile 545 550 555 560 Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro 565 570 575 Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val 580 585 590 Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile 595 600 605 Lys Phe Asp Ser Ile Cys Leu Tyr Ala Thr Phe Phe Pro Met Ala His 610 615 620 Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp 625 630 635 640 Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile 645 650 655 Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp 660 665 670 Ala Ala Phe Arg Gly Trp Ala Phe Thr Arg Leu Lys Thr Lys Glu Thr 675 680 685 Pro Ser Leu Gly Ser Gly Tyr Asp Pro Tyr Tyr Thr Tyr Ser Gly Ser 690 695 700 Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys 705 710 715 720 Val Ala Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg 725 730 735 Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu 740 745 750 Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val 755 760 765 Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Ile Pro 770 775 780 Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro 785 790 795 800 Met Ser Arg Gln Val Val Asp Asp Thr Lys Tyr Lys Asp Tyr Gln Gln 805 810 815 Val Gly Ile Leu His Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu 820 825 830 Ala Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala Asn Phe Pro Tyr 835 840 845 Pro Leu Ile Gly Lys Thr Ala Val Asp Ser Ile Thr Gln Lys Lys Phe 850 855 860 Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met 865 870 875 880 Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn 885 890 895 Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu 900 905 910 Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Val Arg Val 915 920 925 His Arg Pro His Arg Gly Val Ile Glu Thr Val Tyr Leu Arg Thr Pro 930 935 940 Phe Ser Ala Gly Asn Ala Thr Thr 945 950 <210> 47 <211> 266 <212> PRT <213> Human adenovirus type 12 <400> 47 Met Arg Thr Glu Met Thr Pro Leu Val Leu Ser Tyr Gln Glu Ala Asp 1 5 10 15 Asp Ile Leu Glu His Leu Val Asp Asn Phe Phe Asn Glu Val Pro Ser 20 25 30 Asp Asp Asp Leu Tyr Val Pro Ser Leu Tyr Glu Leu Tyr Asp Leu Asp 35 40 45 Val Glu Ser Ala Gly Glu Asp Asn Asn Glu Gln Ala Val Asn Glu Phe 50 55 60 Phe Pro Glu Ser Leu Ile Leu Ala Ala Ser Glu Gly Leu Phe Leu Pro 65 70 75 80 Glu Pro Pro Val Leu Ser Pro Val Cys Glu Pro Ile Gly Gly Glu Cys 85 90 95 Met Pro Gln Leu His Pro Glu Asp Met Asp Leu Leu Cys Tyr Glu Met 100 105 110 Gly Phe Pro Cys Ser Asp Ser Glu Asp Glu Gln Asp Glu Asn Gly Met 115 120 125 Ala His Val Ser Ala Ser Ala Ala Ala Ala Ala Ala Asp Arg Glu Arg 130 135 140 Glu Glu Phe Gln Leu Asp His Pro Glu Leu Pro Gly His Asn Cys Lys 145 150 155 160 Ser Cys Glu His His Arg Asn Ser Thr Gly Asn Thr Asp Leu Met Cys 165 170 175 Ser Leu Cys Tyr Leu Arg Ala Tyr Asn Met Phe Ile Tyr Ser Pro Val 180 185 190 Ser Asp Asn Glu Pro Glu Pro Asn Ser Thr Leu Asp Gly Asp Glu Arg 195 200 205 Pro Ser Pro Pro Lys Leu Gly Ser Ala Val Pro Glu Gly Val Ile Lys 210 215 220 Pro Val Pro Gln Arg Val Thr Gly Arg Arg Arg Cys Ala Val Glu Ser 225 230 235 240 Ile Leu Asp Leu Ile Gln Glu Glu Glu Arg Glu Gln Thr Val Pro Val 245 250 255 Asp Leu Ser Val Lys Arg Pro Arg Cys Asn 260 265 <210> 48 <211> 261 <212> PRT <213> Human adenovirus type 7 <400> 48 Met Arg His Leu Arg Phe Leu Pro Gln Glu Ile Ile Ser Ser Glu Thr 1 5 10 15 Gly Ile Glu Ile Leu Glu Phe Val Val Asn Thr Leu Met Gly Asp Asp 20 25 30 Pro Glu Pro Pro Val Gln Pro Phe Asp Pro Pro Thr Leu His Asp Leu 35 40 45 Tyr Asp Leu Glu Val Asp Gly Pro Glu Asp Pro Asn Glu Gly Ala Val 50 55 60 Asn Gly Phe Phe Thr Asp Ser Met Leu Leu Ala Ala Asp Glu Gly Leu 65 70 75 80 Asp Ile Asn Pro Pro Pro Glu Thr Leu Val Thr Pro Gly Val Val Val 85 90 95 Glu Ser Gly Arg Gly Gly Lys Lys Leu Pro Asp Leu Gly Ala Ala Glu 100 105 110 Met Asp Leu Arg Cys Tyr Glu Glu Gly Phe Pro Pro Ser Asp Asp Glu 115 120 125 Asp Gly Glu Thr Glu Gln Ser Ile His Thr Ala Val Asn Glu Gly Val 130 135 140 Lys Ala Ala Ser Asp Val Phe Lys Leu Asp Cys Pro Glu Leu Pro Gly 145 150 155 160 His Gly Cys Lys Ser Cys Glu Phe His Arg Asn Asn Thr Gly Met Lys 165 170 175 Glu Leu Leu Cys Ser Leu Cys Tyr Met Arg Met His Cys His Phe Ile 180 185 190 Tyr Ser Pro Val Ser Asp Asp Glu Ser Pro Ser Pro Asp Ser Thr Thr 195 200 205 Ser Pro Pro Glu Ile Gln Ala Pro Ala Pro Ala Asn Val Cys Lys Pro 210 215 220 Ile Pro Val Lys Pro Lys Pro Gly Lys Arg Pro Ala Val Asp Lys Leu 225 230 235 240 Glu Asp Leu Leu Glu Gly Gly Asp Gly Pro Leu Asp Leu Ser Thr Arg 245 250 255 Lys Leu Pro Arg Gln 260 <210> 49 <211> 289 <212> PRT <213> Human adenovirus type 2 <400> 49 Met Arg His Ile Ile Cys His Gly Gly Val Ile Thr Glu Glu Met Ala 1 5 10 15 Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val Leu Ala Asp Asn Leu 20 25 30 Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu His Glu Leu Tyr Asp 35 40 45 Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu Glu Ala Val Ser Gln 50 55 60 Ile Phe Pro Asp Ser Val Met Leu Ala Val Gln Glu Gly Ile Asp Leu 65 70 75 80 Leu Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu Pro Pro His Leu Ser 85 90 95 Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu Gly Pro Val Ser Met 100 105 110 Pro Asn Leu Val Pro Glu Val Ile Asp Leu Thr Cys His Glu Ala Gly 115 120 125 Phe Pro Pro Ser Asp Asp Glu Asp Glu Glu Gly Glu Glu Phe Val Leu 130 135 140 Asp Tyr Val Glu His Pro Gly His Gly Cys Arg Ser Cys His Tyr His 145 150 155 160 Arg Arg Asn Thr Gly Asp Pro Asp Ile Met Cys Ser Leu Cys Tyr Met 165 170 175 Arg Thr Cys Gly Met Phe Val Tyr Ser Pro Val Ser Glu Pro Glu Pro 180 185 190 Glu Pro Glu Pro Glu Pro Glu Pro Ala Arg Pro Thr Arg Arg Pro Lys 195 200 205 Leu Val Pro Ala Ile Leu Arg Arg Pro Thr Ser Pro Val Ser Arg Glu 210 215 220 Cys Asn Ser Ser Thr Asp Ser Cys Asp Ser Gly Pro Ser Asn Thr Pro 225 230 235 240 Pro Glu Ile His Pro Val Val Pro Leu Cys Pro Ile Lys Pro Val Ala 245 250 255 Val Arg Val Gly Gly Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu 260 265 270 Leu Asn Glu Ser Gly Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg 275 280 285 Pro <210> 50 <211> 289 <212> PRT <213> Human adenovirus type 5 <400> 50 Met Arg His Ile Ile Cys His Gly Gly Val Ile Thr Glu Glu Met Ala 1 5 10 15 Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val Leu Ala Asp Asn Leu 20 25 30 Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu His Glu Leu Tyr Asp 35 40 45 Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu Glu Ala Val Ser Gln 50 55 60 Ile Phe Pro Asp Ser Val Met Leu Ala Val Gln Glu Gly Ile Asp Leu 65 70 75 80 Leu Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu Pro Pro His Leu Ser 85 90 95 Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu Gly Pro Val Ser Met 100 105 110 Pro Asn Leu Val Pro Glu Val Ile Asp Leu Thr Cys His Glu Ala Gly 115 120 125 Phe Pro Pro Ser Asp Asp Glu Asp Glu Glu Gly Glu Glu Phe Val Leu 130 135 140 Asp Tyr Val Glu His Pro Gly His Gly Cys Arg Ser Cys His Tyr His 145 150 155 160 Arg Arg Asn Thr Gly Asp Pro Asp Ile Met Cys Ser Leu Cys Tyr Met 165 170 175 Arg Thr Cys Gly Met Phe Val Tyr Ser Pro Val Ser Glu Pro Glu Pro 180 185 190 Glu Pro Glu Pro Glu Pro Glu Pro Ala Arg Pro Thr Arg Arg Pro Lys 195 200 205 Met Ala Pro Ala Ile Leu Arg Arg Pro Thr Ser Pro Val Ser Arg Glu 210 215 220 Cys Asn Ser Ser Thr Asp Ser Cys Asp Ser Gly Pro Ser Asn Thr Pro 225 230 235 240 Pro Glu Ile His Pro Val Val Pro Leu Cys Pro Ile Lys Pro Val Ala 245 250 255 Val Arg Val Gly Gly Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu 260 265 270 Leu Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg 275 280 285 Pro <210> 51 <211> 251 <212> PRT <213> Human adenovirus type 9 <400> 51 Met Arg His Leu Arg Leu Leu Pro Ser Thr Val Pro Gly Glu Leu Ala 1 5 10 15 Val Leu Met Leu Glu Asp Phe Val Asp Thr Val Leu Glu Asp Glu Leu 20 25 30 His Pro Ser Pro Phe Glu Leu Gly Pro Thr Leu Gln Asp Leu Tyr Asp 35 40 45 Leu Glu Val Asp Ala His Asp Asp Asp Pro Asn Glu Glu Ala Val Asn 50 55 60 Leu Ile Phe Pro Glu Ser Met Ile Leu Gln Ala Asp Ile Ala Asn Glu 65 70 75 80 Ser Thr Pro Leu His Thr Pro Thr Leu Ser Pro Ile Pro Glu Leu Glu 85 90 95 Glu Glu Asp Glu Leu Asp Leu Arg Cys Tyr Glu Glu Gly Phe Pro Pro 100 105 110 Ser Asp Ser Glu Asp Glu Arg Gly Glu Gln Thr Met Ala Leu Ile Ser 115 120 125 Asp Tyr Ala Cys Val Ile Val Glu Glu Gln Asp Val Ile Glu Lys Ser 130 135 140 Thr Glu Pro Val Gln Gly Cys Arg Asn Cys Gln Tyr His Arg Asp Lys 145 150 155 160 Ser Gly Asp Val Asn Ala Ser Cys Ala Leu Cys Tyr Met Lys Gln Thr 165 170 175 Phe Ser Phe Ile Tyr Ser Pro Val Ser Glu Asp Glu Leu Ser Pro Ser 180 185 190 Glu Glu Asp His Pro Ser Pro Pro Glu Leu Ser Gly Glu Thr Pro Leu 195 200 205 Gln Val Phe Arg Pro Thr Pro Val Arg Pro Ser Gly Glu Arg Arg Ala 210 215 220 Ala Val Asp Lys Ile Glu Asp Leu Leu Gln Asp Met Gly Gly Asp Glu 225 230 235 240 Pro Leu Asp Leu Ser Leu Lys Arg Pro Arg Asn 245 250 <210> 52 <211> 257 <212> PRT <213> Human adenovirus type 4 <400> 52 Met Arg His Leu Arg Asp Leu Pro Asp Glu Glu Ile Ile Ile Ala Ser 1 5 10 15 Gly Ser Glu Ile Leu Glu Leu Val Val Asn Ala Met Met Gly Asp Asp 20 25 30 His Pro Glu Pro Pro Thr Pro Phe Glu Thr Pro Ser Leu His Asp Leu 35 40 45 Tyr Asp Leu Glu Val Asp Val Pro Glu Asp Asp Pro Asn Glu Lys Ala 50 55 60 Val Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Glu Ala 65 70 75 80 Ser Ser Pro Ser Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg His 85 90 95 Asp Arg Gly Glu Lys Glu Ile Pro Gly Leu Lys Trp Glu Lys Met Asp 100 105 110 Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Asp Glu 115 120 125 Gln Ala Ile Gln Asn Ala Ala Ser His Gly Val Gln Ala Val Ser Glu 130 135 140 Ser Phe Ala Leu Asp Cys Pro Pro Leu Pro Gly His Gly Cys Lys Ser 145 150 155 160 Cys Glu Phe His Arg Ile Asn Thr Gly Asp Lys Ala Val Leu Cys Ala 165 170 175 Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr Ser Pro Val Ser 180 185 190 Asp Ala Asp Asp Glu Thr Pro Thr Thr Glu Ser Thr Leu Ser Pro Pro 195 200 205 Glu Ile Gly Thr Ser Pro Ser Asp Asn Ile Val Arg Pro Val Pro Val 210 215 220 Arg Ala Thr Gly Arg Arg Ala Ala Val Glu Cys Leu Asp Asp Leu Leu 225 230 235 240 Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro Arg 245 250 255 His <210> 53 <211> 249 <212> PRT <213> Human adenovirus type 40 <400> 53 Met Arg Met Leu Pro Asp Phe Phe Thr Gly Asn Trp Asp Asp Met Phe 1 5 10 15 Gln Gly Leu Leu Glu Thr Glu Tyr Val Phe Asp Phe Pro Glu Pro Ser 20 25 30 Glu Ala Ser Glu Glu Met Ser Leu His Asp Leu Phe Asp Val Glu Val 35 40 45 Asp Gly Phe Glu Glu Asp Ala Asn Gln Glu Ala Val Asp Gly Met Phe 50 55 60 Pro Glu Arg Leu Leu Ser Glu Ala Glu Ser Ala Ala Glu Ser Gly Ser 65 70 75 80 Gly Asp Ser Gly Val Gly Glu Glu Leu Leu Pro Val Asp Leu Asp Leu 85 90 95 Lys Cys Tyr Glu Asp Gly Leu Pro Pro Ser Asp Pro Glu Thr Asp Glu 100 105 110 Ala Thr Glu Ala Glu Glu Glu Ala Ala Met Pro Thr Tyr Val Asn Glu 115 120 125 Asn Glu Asn Glu Leu Val Leu Asp Cys Pro Glu Asn Pro Gly Arg Gly 130 135 140 Cys Arg Ala Cys Asp Phe His Arg Gly Thr Ser Gly Asn Pro Glu Ala 145 150 155 160 Met Cys Ala Leu Cys Tyr Met Arg Leu Thr Gly His Cys Ile Tyr Ser 165 170 175 Pro Ile Ser Asp Ala Glu Gly Glu Ser Glu Ser Gly Ser Pro Glu Asp 180 185 190 Thr Asp Phe Pro His Pro Leu Thr Ala Thr Pro Pro His Gly Ile Val 195 200 205 Arg Thr Ile Pro Cys Arg Val Ser Cys Arg Arg Arg Pro Ala Val Glu 210 215 220 Cys Ile Glu Asp Leu Leu Glu Glu Asp Pro Thr Asp Glu Pro Leu Asn 225 230 235 240 Leu Ser Leu Lys Arg Pro Lys Cys Ser 245 <210> 54 <211> 233 <212> PRT <213> Human adenovirus type 52 <400> 54 Met Arg Leu Val Pro Glu Met Tyr Gly Val Phe Cys Ser Glu Thr Val 1 5 10 15 Arg Asn Ser Asp Glu Leu Leu Asn Thr Asp Leu Leu Asp Val Pro Asn 20 25 30 Ser Pro Val Thr Ser Pro Pro Ser Leu His Asp Leu Phe Asp Val Glu 35 40 45 Val Asp Pro Pro Gln Asp Pro Asn Glu Asp Ala Val Asn Ser Met Phe 50 55 60 Pro Glu Cys Leu Phe Glu Ala Ala Glu Glu Gly Ser His Ser Ser Glu 65 70 75 80 Glu Ser Lys Arg Gly Glu Glu Leu Asp Leu Lys Cys Tyr Glu Glu Cys 85 90 95 Leu Pro Ser Ser Asp Ser Glu Thr Glu Gln Thr Gly Gly Asp Gly Cys 100 105 110 Thr Glu Pro Val Val Lys Asn Glu Pro Val Leu Asp Arg Pro Asp Gln 115 120 125 Pro Gly His Gly Cys Arg Ala Cys Ala Phe His Arg Asn Ala Ser Gly 130 135 140 Asn Pro Glu Thr Leu Cys Ala Leu Cys Tyr Leu Arg Leu Thr Ser Asp 145 150 155 160 Phe Val Tyr Ser Asp Val Ser Asp Ala Glu Gly Asp Gly Asp Arg Ser 165 170 175 Gly Ser Ala Asn Ser Pro Cys Thr Leu Gly Ala Val Val Pro Val Gly 180 185 190 Ile Ile Lys Pro Val Ala Val Arg Val Ser Gly Arg Arg Cys Ala Val 195 200 205 Glu Lys Leu Glu Asp Leu Leu Gln Glu Glu Gln Thr Glu Pro Leu Asp 210 215 220 Leu Ser Met Lys Arg Pro Lys Leu Thr 225 230 <210> 55 <211> 127 <212> PRT <213> Human adenovirus type 12 <400> 55 Met Ala Ala Phe Glu Thr Leu Tyr Val Tyr Phe Thr Gly Pro Gly Ala 1 5 10 15 Met Leu Pro Lys Gln Glu Gly Asp Ser Asn Ala Tyr Val Leu Phe Ser 20 25 30 Pro Ala Asn Phe Val Ile Pro Pro His Gly Val Val Leu Leu Tyr Leu 35 40 45 His Ile Ala Val Asp Ile Pro Pro Gly Tyr Leu Gly Thr Leu Phe Ser 50 55 60 Leu Cys Asp Met Asn Ala Arg Gly Val Phe Val Gly Ala Glu Thr Leu 65 70 75 80 Tyr Pro Gly Ser Arg Met Glu Leu Ser Val Leu Leu Phe Asn His Ser 85 90 95 Asp Val Phe Cys Asp Val Arg Ala Lys Gln Pro Val Ala Arg Leu Leu 100 105 110 Leu Ser Arg Val Val Phe Pro Pro Val Cys Gln Ala Ser Leu Ile 115 120 125 <210> 56 <211> 125 <212> PRT <213> Human adenovirus type 7 <400> 56 Met Ala Asp Glu Ala Leu Tyr Val Tyr Leu Glu Gly Pro Gly Ala Thr 1 5 10 15 Leu Pro Glu Gln Gln Gln Arg Asn Asn Tyr Ile Phe Tyr Ser Pro Val 20 25 30 Pro Phe Thr Leu Tyr Pro Arg Gly Val Ala Leu Leu Tyr Leu Arg Leu 35 40 45 Ser Ile Ile Ile Pro Arg Gly Tyr Val Gly Cys Phe Phe Ser Leu Thr 50 55 60 Asp Ala Asn Met Ser Gly Leu Tyr Ala Ser Ser Arg Ile Ile His Ala 65 70 75 80 Gly His Arg Glu Glu Leu Ser Val Leu Leu Phe Asn His Asp Asp Arg 85 90 95 Phe Tyr Glu Gly Arg Ala Gly Asp Pro Val Ala Cys Leu Val Met Glu 100 105 110 Arg Leu Ile Tyr Pro Pro Val Arg Gln Ala Thr Met Ile 115 120 125 <210> 57 <211> 128 <212> PRT <213> Human adenovirus type 2 <400> 57 Met Ala Ala Ala Val Glu Ala Leu Tyr Val Val Leu Glu Arg Glu Gly 1 5 10 15 Ala Ile Leu Pro Arg Gln Glu Gly Phe Ser Gly Val Tyr Val Phe Phe 20 25 30 Ser Pro Ile Asn Phe Val Ile Pro Pro Met Gly Ala Val Met Leu Ser 35 40 45 Leu Arg Leu Arg Val Cys Ile Pro Pro Gly Tyr Phe Gly Arg Phe Leu 50 55 60 Ala Leu Thr Asp Val Asn Gln Pro Asp Val Phe Thr Glu Ser Tyr Ile 65 70 75 80 Met Thr Pro Asp Met Thr Glu Glu Leu Ser Val Val Leu Phe Asn His 85 90 95 Gly Asp Gln Phe Phe Tyr Gly His Ala Gly Met Ala Val Val Arg Leu 100 105 110 Met Leu Ile Arg Val Val Phe Pro Val Val Arg Gln Ala Ser Asn Val 115 120 125 <210> 58 <211> 128 <212> PRT <213> Human adenovirus type 5 <400> 58 Met Ala Ala Ala Val Glu Ala Leu Tyr Val Val Leu Glu Arg Glu Gly 1 5 10 15 Ala Ile Leu Pro Arg Gln Glu Gly Phe Ser Gly Val Tyr Val Phe Phe 20 25 30 Ser Pro Ile Asn Phe Val Ile Pro Pro Met Gly Ala Val Met Leu Ser 35 40 45 Leu Arg Leu Arg Val Cys Ile Pro Pro Gly Tyr Phe Gly Arg Phe Leu 50 55 60 Ala Leu Thr Asp Val Asn Gln Pro Asp Val Phe Thr Glu Ser Tyr Ile 65 70 75 80 Met Thr Pro Asp Met Thr Glu Glu Leu Ser Val Val Leu Phe Asn His 85 90 95 Gly Asp Gln Phe Phe Tyr Gly His Ala Gly Met Ala Val Val Arg Leu 100 105 110 Met Leu Ile Arg Val Val Phe Pro Val Val Arg Gln Ala Ser Asn Val 115 120 125 <210> 59 <211> 125 <212> PRT <213> Human adenovirus type 9 <400> 59 Met Ala Glu Ser Leu Tyr Ala Phe Ile Asp Ser Pro Gly Gly Ile Ala 1 5 10 15 Pro Val Gln Glu Gly Thr Ser Asn Arg Tyr Thr Phe Phe Cys Pro Glu 20 25 30 Ser Phe His Ile Pro Pro His Gly Val Val Leu Leu His Leu Lys Val 35 40 45 Ser Val Leu Val Pro Thr Gly Tyr Gln Gly Arg Phe Met Ala Leu Asn 50 55 60 Asp Tyr His Ala Arg Asp Ile Leu Thr Gln Ser Asp Val Ile Phe Ala 65 70 75 80 Gly Arg Arg Gln Glu Leu Thr Val Leu Leu Phe Asn His Thr Asp Arg 85 90 95 Phe Leu Tyr Val Arg Lys Gly His Pro Val Gly Thr Leu Leu Leu Glu 100 105 110 Arg Val Ile Phe Pro Ser Val Lys Ile Ala Thr Leu Val 115 120 125 <210> 60 <211> 124 <212> PRT <213> Human adenovirus type 4 <400> 60 Met Asp Ala Gln Val Leu Tyr Val Phe Leu Glu Gly Ala Gly Ala Leu 1 5 10 15 Leu Pro Val Gln Lys Gly Ser Asn Tyr Ile Phe Tyr Ala Pro Ala Asn 20 25 30 Phe Val Leu His Pro His Gly Val Ala Leu Leu Glu Leu Arg Leu Ser 35 40 45 Ile Val Val Pro Gln Gly Phe Ile Gly Arg Phe Phe Ser Leu Thr Asp 50 55 60 Ala Asn Val Pro Gly Val Tyr Ala Ser Ser Arg Ile Ile His Ala Gly 65 70 75 80 His Arg Glu Gly Leu Ser Val Met Leu Phe Asn His Asn Val Ser Phe 85 90 95 Tyr Asn Gly Arg Ala Gly Asp Pro Val Ala Cys Leu Val Leu Glu Arg 100 105 110 Val Ile Tyr Pro Pro Val Arg Gln Ala Ser Met Val 115 120 <210> 61 <211> 126 <212> PRT <213> Human adenovirus type 52 <400> 61 Met Ala Asp Gln His Ile Tyr Val His Leu Leu Gly Arg Arg Ala Phe 1 5 10 15 Leu Pro Gln Gln Gln Gly Tyr Ser Asn Met Tyr Val Leu Phe Ser Pro 20 25 30 Glu Asp Phe Val Leu Ala Pro Arg Gly Ile Ile Leu Leu Ser Leu Gln 35 40 45 Leu Ser Leu Asp Ile Pro Thr Gly Tyr Leu Gly Arg Phe Phe Ser Val 50 55 60 Ala Asp Met Asn Val Arg Gly Val Leu Leu Cys Ala Gln Glu Ile Gln 65 70 75 80 Pro Ser Thr Trp Trp Glu Val Ser Val Val Leu Phe Asn His Ser Asp 85 90 95 Glu Phe Tyr Arg Gly Ser Arg Gly Gln Pro Val Ala Cys Leu Leu Leu 100 105 110 Glu Arg Val Ile Tyr Pro Thr Val Arg Gln Ala Ser Leu Val 115 120 125 <210> 62 <211> 35937 <212> DNA <213> Human adenovirus type 2 <400> 62 catcatcata atatacctta ttttggattg aagccaatat gataatgagg gggtggagtt 60 tgtgacgtgg cgcggggcgt gggaacgggg cgggtgacgt agtagtgtgg cggaagtgtg 120 atgttgcaag tgtggcggaa cacatgtaag cgccggatgt ggtaaaagtg acgtttttgg 180 tgtgcgccgg tgtatacggg aagtgacaat tttcgcgcgg ttttaggcgg atgttgtagt 240 aaatttgggc gtaaccaagt aatgtttggc cattttcgcg ggaaaactga ataagaggaa 300 gtgaaatctg aataattctg tgttactcat agcgcgtaat atttgtctag ggccgcgggg 360 actttgaccg tttacgtgga gactcgccca ggtgtttttc tcaggtgttt tccgcgttcc 420 gggtcaaagt tggcgtttta ttattatagt cagctgacgc gcagtgtatt tatacccggt 480 gagttcctca agaggccact cttgagtgcc agcgagtaga gttttctcct ccgagccgct 540 ccgacaccgg gactgaaaat gagacatatt atctgccacg gaggtgttat taccgaagaa 600 atggccgcca gtcttttgga ccagctgatc gaagaggtac tggctgataa tcttccacct 660 cctagccatt ttgaaccacc tacccttcac gaactgtatg atttagacgt gacggccccc 720 gaagatccca acgaggaggc ggtttcgcag atttttcccg agtctgtaat gttggcggtg 780 caggaaggga ttgacttatt cacttttccg ccggcgcccg gttctccgga gccgcctcac 840 ctttcccggc agcccgagca gccggagcag agagccttgg gtccggtttc tatgccaaac 900 cttgtgccgg aggtgatcga tcttacctgc cacgaggctg gctttccacc cagtgacgac 960 gaggatgaag agggtgagga gtttgtgtta gattatgtgg agcaccccgg gcacggttgc 1020 aggtcttgtc attatcaccg gaggaatacg ggggacccag atattatgtg ttcgctttgc 1080 tatatgagga cctgtggcat gtttgtctac agtaagtgaa aattatgggc agtcggtgat 1140 agagtggtgg gtttggtgtg gtaatttttt tttaattttt acagttttgt ggtttaaaga 1200 attttgtatt gtgatttttt aaaaggtcct gtgtctgaac ctgagcctga gcccgagcca 1260 gaaccggagc ctgcaagacc tacccggcgt cctaaattgg tgcctgctat cctgagacgc 1320 ccgacatcac ctgtgtctag agaatgcaat agtagtacgg atagctgtga ctccggtcct 1380 tctaacacac ctcctgagat acacccggtg gtcccgctgt gccccattaa accagttgcc 1440 gtgagagttg gtgggcgtcg ccaggctgtg gaatgtatcg aggacttgct taacgagtct 1500 gggcaacctt tggacttgag ctgtaaacgc cccaggccat aaggtgtaaa cctgtgattg 1560 cgtgtgtggt taacgccttt gtttgctgaa tgagttgatg taagtttaat aaagggtgag 1620 ataatgttta acttgcatgg cgtgttaaat ggggcggggc ttaaagggta tataatgcgc 1680 cgtgggctaa tcttggttac atctgacctc atggaggctt gggagtgttt ggaagatttt 1740 tctgctgtgc gtaacttgct ggaacagagc tctaacagta cctcttggtt ttggaggttt 1800 ctgtggggct cctcccaggc aaagttagtc tgcagaatta aggaggatta caagtgggaa 1860 tttgaagagc ttttgaaatc ctgtggtgag ctgtttgatt ctttgaatct gggtcaccag 1920 gcgcttttcc aagagaaggt catcaagact ttggattttt ccacaccggg gcgcgctgcg 1980 gctgctgttg cttttttgag ttttataaag gataaatgga gcgaagaaac ccatctgagc 2040 ggggggtacc tgctggattt tctggccatg catctgtgga gagcggtggt gagacacaag 2100 aatcgcctgc tactgttgtc ttccgtccgc ccggcaataa taccgacgga ggagcaacag 2160 caggaggaag ccaggcggcg gcggcggcag gagcagagcc catggaaccc gagagccggc 2220 ctggaccctc gggaatgaat gttgtacagg tggctgaact gtttccagaa ctgagacgca 2280 ttttaaccat taacgaggat gggcaggggc taaagggggt aaagagggag cggggggctt 2340 ctgaggctac agaggaggct aggaatctaa cttttagctt aatgaccaga caccgtcctg 2400 agtgtgttac ttttcagcag attaaggata attgcgctaa tgagcttgat ctgctggcgc 2460 agaagtattc catagagcag ctgaccactt actggctgca gccaggggat gattttgagg 2520 aggctattag ggtatatgca aaggtggcac ttaggccaga ttgcaagtac aagattagca 2580 aacttgtaaa tatcaggaat tgttgctaca tttctgggaa cggggccgag gtggagatag 2640 atacggagga tagggtggcc tttagatgta gcatgataaa tatgtggccg ggggtgcttg 2700 gcatggacgg ggtggttatt atgaatgtga ggtttactgg tcccaatttt agcggtacgg 2760 ttttcctggc caataccaat cttatcctac acggtgtaag cttctatggg tttaacaata 2820 cctgtgtgga agcctggacc gatgtaaggg ttcggggctg tgccttttac tgctgctgga 2880 agggggtggt gtgtcgcccc aaaagcaggg cttcaattaa gaaatgcctg tttgaaaggt 2940 gtaccttggg tatcctgtct gagggtaact ccagggtgcg ccacaatgtg gcctccgact 3000 gtggttgctt catgctagtg aaaagcgtgg ctgtgattaa gcataacatg gtgtgtggca 3060 actgcgagga cagggcctct cagatgctga cctgctcgga cggcaactgt cacttgctga 3120 agaccattca cgtagccagc cactctcgca aggcctggcc agtgtttgag cacaacatac 3180 tgacccgctg ttccttgcat ttgggtaaca ggaggggggt gttcctacct taccaatgca 3240 atttgagtca cactaagata ttgcttgagc ccgagagcat gtccaaggtg aacctgaacg 3300 gggtgtttga catgaccatg aagatctgga aggtgctgag gtacgatgag acccgcacca 3360 ggtgcagacc ctgcgagtgt ggcggtaaac atattaggaa ccagcctgtg atgctggatg 3420 tgaccgagga gctgaggccc gatcacttgg tgctggcctg cacccgcgct gagtttggct 3480 ctagcgatga agatacagat tgaggtactg aaatgtgtgg gcgtggctta agggtgggaa 3540 agaatatata aggtgggggt ctcatgtagt tttgtatctg ttttgcagca gccgccgcca 3600 tgagcgccaa ctcgtttgat ggaagcattg tgagctcata tttgacaacg cgcatgcccc 3660 catgggccgg ggtgcgtcag aatgtgatgg gctccagcat tgatggtcgc cccgtcctgc 3720 ccgcaaactc tactaccttg acctacgaga ccgtgtctgg aacgccgttg gagactgcag 3780 cctccgccgc cgcttcagcc gctgcagcca ccgcccgcgg gattgtgact gactttgctt 3840 tcctgagccc gcttgcaagc agtgcagctt cccgttcatc cgcccgcgat gacaagttga 3900 cggctctttt ggcacaattg gattctttga cccgggaact taatgtcgtt tctcagcagc 3960 tgttggatct gcgccagcag gtttctgccc tgaaggcttc ctcccctccc aatgcggttt 4020 aaaacataaa taaaaaccag actctgtttg gattttgatc aagcaagtgt cttgctgtct 4080 ttatttaggg gttttgcgcg cgcggtaggc ccgggaccag cggtctcggt cgttgagggt 4140 cctgtgtatt ttttccagga cgtggtaaag gtgactctgg atgttcagat acatgggcat 4200 aagcccgtct ctggggtgga ggtagcacca ctgcagagct tcatgctgcg gggtggtgtt 4260 gtagatgatc cagtcgtagc aggagcgctg ggcgtggtgc ctaaaaatgt ctttcagtag 4320 caagctgatt gccaggggca ggcccttggt gtaagtgttt acaaagcggt taagctggga 4380 tgggtgcata cgtggggata tgagatgcat cttggactgt atttttaggt tggctatgtt 4440 cccagccata tccctccggg gattcatgtt gtgcagaacc accagcacag tgtatccggt 4500 gcacttggga aatttgtcat gtagcttaga aggaaatgcg tggaagaact tggagacgcc 4560 cttgtgacct ccgagatttt ccatgcattc gtccataatg atggcaatgg gcccacgggc 4620 ggcggcctgg gcgaagatat ttctgggatc actaacgtca tagttgtgtt ccaggatgag 4680 atcgtcatag gccattttta caaagcgcgg gcggagggtg ccagactgcg gtataatggt 4740 tccatccggc ccaggggcgt agttaccctc acagatttgc atttcccacg ctttgagttc 4800 agatgggggg atcatgtcta cctgcggggc gatgaagaaa accgtttccg gggtagggga 4860 gatcagctgg gaagaaagca ggttcctgag cagctgcgac ttaccgcagc cggtgggccc 4920 gtaaatcaca cctattaccg gctgcaactg gtagttaaga gagctgcagc tgccgtcatc 4980 cctgagcagg ggggccactt cgttaagcat gtccctgact tgcatgtttt ccctgaccaa 5040 atgcgccaga aggcgctcgc cgcccagcga tagcagttct tgcaaggaag caaagttttt 5100 caacggtttg aggccgtccg ccgtaggcat gcttttgagc gtttgaccaa gcagttccag 5160 gcggtcccac agctcggtca cgtgctctac ggcatctcga tccagcatat ctcctcgttt 5220 cgcgggttgg ggcggctttc gctgtacggc agtagtcggt gctcgtccag acgggccagg 5280 gtcatgtctt tccacgggcg cagggtcctc gtcagcgtag tctgggtcac ggtgaagggg 5340 tgcgctccgg gctgcgcgct ggccagggtg cgcttgaggc tggtcctgct ggtgctgaag 5400 cgctgccggt cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt gtcatagtcc 5460 agcccctccg cggcgtggcc cttggcgcgc agcttgccct tggaggaggc gccgcacgag 5520 gggcagtgca gacttttaag ggcgtagagc ttgggcgcga gaaataccga ttccggggag 5580 taggcatccg cgccgcaggc cccgcagacg gtctcgcatt ccacgagcca ggtgagctct 5640 ggccgttcgg ggtcaaaaac caggtttccc ccatgctttt tgatgcgttt cttacctctg 5700 gtttccatga gccggtgtcc acgctcggtg acgaaaaggc tgtccgtgtc cccgtataca 5760 gacttgagag gcctgtcctc gagcggtgtt ccgcggtcct cctcgtatag aaactcggac 5820 cactctgaga cgaaggctcg cgtccaggcc agcacgaagg aggctaagtg ggaggggtag 5880 cggtcgttgt ccactagggg gtccactcgc tccagggtgt gaagacacat gtcgccctct 5940 tcggcatcaa ggaaggtgat tggtttatag gtgtaggcca cgtgaccggg tgttcctgaa 6000 ggggggctat aaaagggggt gggggcgcgt tcgtcctcac tctcttccgc atcgctgtct 6060 gcgagggcca gctgttgggg tgagtactcc ctctcaaaag cgggcatgac ttctgcgcta 6120 agattgtcag tttccaaaaa cgaggaggat ttgatattca cctggcccgc ggtgatgcct 6180 ttgagggtgg ccgcgtccat ctggtcagaa aagacaatct ttttgttgtc aagcttggtg 6240 gcaaacgacc cgtagagggc gttggacagc aacttggcga tggagcgcag ggtttggttt 6300 ttgtcgcgat cggcgcgctc cttggccgcg atgtttagct gcacgtattc gcgcgcaacg 6360 caccgccatt cgggaaagac ggtggtgcgc tcgtcgggca ccaggtgcac gcgccaaccg 6420 cggttgtgca gggtgacaag gtcaacgctg gtggctacct ctccgcgtag gcgctcgttg 6480 gtccagcaga ggcggccgcc cttgcgcgaa cagaatggcg gtagtgggtc tagctgcgtc 6540 tcgtccgggg ggtctgcgtc cacggtaaag accccgggca gcaggcgcgc gtcgaagtag 6600 tctatcttgc atccttgcaa gtctagcgcc tgctgccatg cgcgggcggc aagcgcgcgc 6660 tcgtatgggt tgagtggggg accccatggc atggggtggg tgagcgcgga ggcgtacatg 6720 ccgcaaatgt cgtaaacgta gaggggctct ctgagtattc caagatatgt agggtagcat 6780 cttccaccgc ggatgctggc gcgcacgtaa tcgtatagtt cgtgcgaggg agcgaggagg 6840 tcgggaccga ggttgctacg ggcgggctgc tctgctcgga agactatctg cctgaagatg 6900 gcatgtgagt tggatgatat ggttggacgc tggaagacgt tgaagctggc gtctgtgaga 6960 cctaccgcgt cacgcacgaa ggaggcgtag gagtcgcgca gcttgttgac cagctcggcg 7020 gtgacctgca cgtctagggc gcagtagtcc agggtttcct tgatgatgtc atacttatcc 7080 tgtccctttt ttttccacag ctcgcggttg aggacaaact cttcgcggtc tttccagtac 7140 tcttggatcg gaaacccgtc ggcctccgaa cggtaagagc ctagcatgta gaactggttg 7200 acggcctggt aggcgcagca tcccttttct acgggtagcg cgtatgcctg cgcggccttc 7260 cggagcgagg tgtgggtgag cgcaaaggtg tccctaacca tgactttgag gtactggtat 7320 ttgaagtcag tgtcgtcgca tccgccctgc tcccagagca aaaagtccgt gcgctttttg 7380 gaacgcgggt ttggcagggc gaaggtgaca tcgttgaaaa gtatctttcc cgcgcgaggc 7440 ataaagttgc gtgtgatgcg gaagggtccc ggcacctcgg aacggttgtt aattacctgg 7500 gcggcgagca cgatctcgtc gaagccgttg atgttgtggc ccacgatgta aagttccaag 7560 aagcgcgggg tgcccttgat ggagggcaat tttttaagtt cctcgtaggt gagctcctca 7620 ggggagctga gcccgtgttc tgacagggcc cagtctgcaa gatgagggtt ggaagcgacg 7680 aatgagctcc acaggtcacg ggccattagc atttgcaggt ggtcgcgaaa ggtcctaaac 7740 tggcgaccta tggccatttt ttctggggtg atgcagtaga aggtaagcgg gtcttgttcc 7800 cagcggtccc atccaaggtc cacggctagg tctcgcgcgg cggtcaccag aggctcatct 7860 ccgccgaact tcataaccag catgaagggc acgagctgct tcccaaaggc ccccatccaa 7920 gtataggtct ctacatcgta ggtgacaaag agacgctcgg tgcgaggatg cgagccgatc 7980 gggaagaact ggatctcccg ccaccagttg gaggagtggc tgttgatgtg gtgaaagtag 8040 aagtccctgc gacgggccga acactcgtgc tggcttttgt aaaaacgtgc gcagtactgg 8100 cagcggtgca cgggctgtac atcctgcacg aggttgacct gacgaccgcg cacaaggaag 8160 cagagtggga atttgagccc ctcgcctggc gggtttggct ggtggtcttc tacttcggct 8220 gcttgtcctt gaccgtctgg ctgctcgagg ggagttatgg tggatcggac caccacgccg 8280 cgcgagccca aagtccagat gtccgcgcgc ggcggtcgga gcttgatgac aacatcgcgc 8340 agatgggagc tgtccatggt ctggagctcc cgcggcgaca ggtcaggcgg gagctcctgc 8400 aggtttacct cgcatagccg ggtcagggcg cgggctaggt ccaggtgata cctgatttcc 8460 aggggctggt tggtggcggc gtcgatgact tgcaagaggc cgcatccccg cggcgcgact 8520 acggtaccgc gcggcgggcg gtgggccgcg ggggtgtcct tggatgatgc atctaaaagc 8580 ggtgacgcgg gcgggccccc ggaggtaggg ggggctcggg acccgccggg agagggggca 8640 ggggcacgtc ggcgccgcgc gcgggcagga gctggtgctg cgcgcggagg ttgctggcga 8700 acgcgacgac gcggcggttg atctcctgaa tctggcgcct ctgcgtgaag acgacgggcc 8760 cggtgagctt gaacctgaaa gagagttcga cagaatcaat ttcggtgtcg ttgacggcgg 8820 cctggcgcaa aatctcctgc acgtctcctg agttgtcttg ataggcgatt tcggccatga 8880 actgctcgat ctcttcctcc tggagatctc cgcgtccggc tcgctccacg gtggcggcga 8940 ggtcgttgga gatgcgggcc atgagctgcg agaaggcgtt gaggcctccc tcgttccaga 9000 cgcggctgta gaccacgccc ccttcggcat cgcgggcgcg catgaccacc tgcgcgagat 9060 tgagctccac gtgccgggcg aagacggcgt agtttcgcag gcgctgaaag aggtagttga 9120 gggtggtggc ggtgtgttct gccacgaaga agtacataac ccagcgtcgc aacgtggatt 9180 cgttgatatc ccccaaggcc tcaaggcgct ccatggcctc gtagaagtcc acggcgaagt 9240 tgaaaaactg ggagttgcgc gccgacacgg ttaactcctc ctccagaaga cggatgagct 9300 cggcgacagt gtcgcgcacc tcgcgctcaa aggctacagg ggcctcttct tcttcaatct 9360 cctcttccat aagggcctcc ccttcttctt cttcttctgg cggcggtggg ggagggggga 9420 cacggcggcg acgacggcgc accgggaggc ggtcgacaaa gcgctcgatc atctccccgc 9480 ggcgacggcg catggtctcg gtgacggcgc ggccgttctc gcgggggcgc agttggaaga 9540 cgccgcccgt catgtcccgg ttatgggttg gcggggggct gccgtgcggc agggatacgg 9600 cgctaacgat gcatctcaac aattgttgtg taggtactcc gccaccgagg gacctgagcg 9660 agtccgcatc gaccggatcg gaaaacctct cgagaaaggc gtctaaccag tcacagtcgc 9720 aaggtaggct gagcaccgtg gcgggcggca gcgggtggcg gtcggggttg tttctggcgg 9780 aggtgctgct gatgatgtaa ttaaagtagg cggtcttgag acggcggatg gtcgacagaa 9840 gcaccatgtc cttgggtccg gcctgctgaa tgcgcaggcg gtcggccatg ccccaggctt 9900 cgttttgaca tcggcgcagg tctttgtagt agtcttgcat gagcctttct accggcactt 9960 cttcttctcc ttcctcttgt cctgcatctc ttgcatctat cgctacggcg gcggcggagt 10020 ttggccgtag gtggcgccct cttcctccca tgcgtgtgac cccgaagccc ctcatcggct 10080 gaagcagggc caggtcggcg acaacgcgct cggctaatat ggcctgctgc acctgcgtga 10140 gggtagactg gaagtcatcc atgtccacaa agcggtggta tgcgcccgtg ttgatggtgt 10200 aagtgcagtt ggccataacg gaccagttaa cggtctggtg acccggctgc gagagctcgg 10260 tgtacctgag acgcgagtaa gcccttgagt caaagacgta gtcgttgcaa gtccgcacca 10320 ggtactgata tcccaccaaa aagtgcggcg gcggctggcg gtagaggggc cagcgtaggg 10380 tggccggggc tccgggggcg aggtcttcca acataaggcg atgatatccg tagatgtacc 10440 tggacatcca ggtgatgccg gcggcggtgg tggaggcgcg cggaaagtcg cggacgcggt 10500 tccagatgtt gcgcagcggc aaaaagtgct ccatggtcgg gacgctctgg ccggtgaggc 10560 gtgcgcagtc gttgacgctc tagaccgtgc aaaaggagag cctgtaagcg ggcactcttc 10620 cgtggtctgg tggataaatt cgcaagggta tcatggcgga cgaccggggt tcgaaccccg 10680 gatccggccg tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc caggtgtgcg 10740 acgtcagaca acgggggagc gctccttttg gcttccttcc aggcgcggcg gctgctgcgc 10800 tagctttttt ggccactggc cgcgcgcggc gtaagcggtt aggctggaaa gcgaaagcat 10860 taagtggctc gctccctgta gccggagggt tattttccaa gggttgagtc gcaggacccc 10920 cggttcgagt ctcgggccgg ccggactgcg gcgaacgggg gtttgcctcc ccgtcatgca 10980 agaccccgct tgcaaattcc tccggaaaca gggacgagcc ccttttttgc ttttcccaga 11040 tgcatccggt gctgcggcag atgcgccccc ctcctcagca gcggcaagag caagagcagc 11100 ggcagacatg cagggcaccc tccccttctc ctaccgcgtc aggaggggca acatccgcgg 11160 ctgacgcggc ggcagatggt gattacgaac ccccgcggcg ccgggcccgg cactacctgg 11220 acttggagga gggcgagggc ctggcgcggc taggagcgcc ctctcctgag cgacacccaa 11280 gggtgcagct gaagcgtgac acgcgcgagg cgtacgtgcc gcggcagaac ctgtttcgcg 11340 accgcgaggg agaggagccc gaggagatgc gggatcgaaa gttccacgca gggcgcgagt 11400 tgcggcatgg cctgaaccgc gagcggttgc tgcgcgagga ggactttgag cccgacgcgc 11460 ggaccgggat tagtcccgcg cgcgcacacg tggcggccgc cgacctggta accgcgtacg 11520 agcagacggt gaaccaggag attaactttc aaaaaagctt taacaaccac gtgcgcacgc 11580 ttgtggcgcg cgaggaggtg gctataggac tgatgcatct gtgggacttt gtaagcgcgc 11640 tggagcaaaa cccaaatagc aagccgctca tggcgcagct gttccttata gtgcagcaca 11700 gcagggacaa cgaggcattc agggatgcgc tgctaaacat agtagagccc gagggccgct 11760 ggctgctcga tttgataaac attctgcaga gcatagtggt gcaggagcgc agcttgagcc 11820 tggctgacaa ggtggccgcc attaactatt ccatgctcag tctgggcaag ttttacgccc 11880 gcaagatata ccatacccct tacgttccca tagacaagga ggtaaagatc gaggggttct 11940 acatgcgcat ggcgttgaag gtgcttacct tgagcgacga cctgggcgtt tatcgcaacg 12000 agcgcatcca caaggccgtg agcgtgagcc ggcggcgcga gctcagcgac cgcgagctga 12060 tgcacagcct gcaaagggcc ctggctggca cgggcagcgg cgatagagag gccgagtcct 12120 actttgacgc gggcgctgac ctgcgctggg ccccaagccg acgcgccctg gaggcagctg 12180 gggccggacc tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc ggcgtggagg 12240 aatatgacga ggacgatgag tacgagccag aggacggcga gtactaagcg gtgatgtttc 12300 tgatcagatg atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc agagccagcc 12360 gtccggcctt aactccacgg acgactggcg ccaggtcatg gaccgcatca tgtcgctgac 12420 tgcgcgtaac cctgacgcgt tccggcagca gccgcaggcc aaccggctct ccgcaattct 12480 ggaagcggtg gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg cgatcgtaaa 12540 cgcgctggcc gaaaacaggg ccatccggcc cgatgaggcc ggcctggtct acgacgcgct 12600 gcttcagcgc gtggctcgtt acaacagcgg caacgtgcag accaacctgg accggctggt 12660 gggggatgtg cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg gcaacctggg 12720 ctccatggtt gcactaaacg ccttcctgag tacacagccc gccaacgtgc cgcggggaca 12780 ggaggactac accaactttg tgagcgcact gcggctaatg gtgactgaga caccgcaaag 12840 tgaggtgtac cagtccgggc cagactattt tttccagacc agtagacaag gcctgcagac 12900 cgtaaacctg agccaggctt tcaagaactt gcaggggctg tggggggtgc gggctcccac 12960 aggcgaccgc gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt tgctgctgct 13020 aatagcgccc ttcacggaca gtggcagcgt gtcccgggac acatacctag gtcacttgct 13080 gacactgtac cgcgaggcca taggtcaggc gcatgtggac gagcatactt tccaggagat 13140 tacaagtgtc agccgcgcgc tggggcagga ggacacgggc agcctggagg caaccctgaa 13200 ctacctgctg accaaccggc ggcagaagat cccctcgttg cacagtttaa acagcgagga 13260 ggagcgcatc ttgcgctatg tgcagcagag cgtgagcctt aacctgatgc gcgacggggt 13320 aacgcccagc gtggcgctgg acatgaccgc gcgcaacatg gaaccgggca tgtatgcctc 13380 aaaccggccg tttatcaatc gcctaatgga ctacttgcat cgcgcggccg ccgtgaaccc 13440 cgagtatttc accaatgcca tcttgaaccc gcactggcta ccgccccctg gtttctacac 13500 cgggggattt gaggtgcccg agggtaacga tggattcctc tgggacgaca tagacgacag 13560 cgtgttttcc ccgcaaccgc agaccctgct agagttgcaa cagcgcgagc aggcagaggc 13620 ggcgctgcga aaggaaagct tccgcaggcc aagcagcttg tccgatctag gcgctgcggc 13680 cccgcggtca gatgcgagta gcccatttcc aagcttgata gggtctttta ccagcactcg 13740 caccacccgc ccgcgcctgc tgggcgagga ggagtaccta aacaactcgc tgctgcagcc 13800 gcagcgcgaa aagaacctgc ctccggcatt tcccaacaac gggatagaga gcctagtgga 13860 caagatgagt agatggaaga cgtatgcgca ggagcacagg gatgtgcccg gcccgcgccc 13920 gcccacccgt cgtcaaaggc acgaccgtca gcggggtctg gtgtgggagg acgatgactc 13980 ggcagacgac agcagcgtcc tggatttggg agggagtggc aacccgtttg cgcaccttcg 14040 ccccaggctg gggagaatgt tttaaaaaaa aaaaaaaaaa gcatgatgca aaataaaaaa 14100 ctcaccaagg ccatggcacc gagcgttggt tttcttgtat tccccttagt atgcagcgcg 14160 cggcgatgta tgaggaaggt cctcctccct cctacgagag cgtggtgagc gcggcgccag 14220 tggcggcggc gctgggttcc cccttcgatg ctcccctgga cccgccgttt gtgcctccgc 14280 ggtacctgcg gcctaccggg gggagaaaca gcatccgtta ctctgagttg gcacccctat 14340 tcgacaccac ccgtgtgtac cttgtggaca acaagtcaac ggatgtggca tccctgaact 14400 accagaacga ccacagcaac tttctaacca cggtcattca aaacaatgac tacagcccgg 14460 gggaggcaag cacacagacc atcaatcttg acgaccgttc gcactggggc ggcgacctga 14520 aaaccatcct gcataccaac atgccaaatg tgaacgagtt catgtttacc aataagttta 14580 aggcgcgggt gatggtgtcg cgctcgctta ctaaggacaa acaggtggag ctgaaatatg 14640 agtgggtgga gttcacgctg cccgagggca actactccga gaccatgacc atagacctta 14700 tgaacaacgc gatcgtggag cactacttga aagtgggcag gcagaacggg gttctggaaa 14760 gcgacatcgg ggtaaagttt gacacccgca acttcagact ggggtttgac ccagtcactg 14820 gtcttgtcat gcctggggta tatacaaacg aagccttcca tccagacatc attttgctgc 14880 caggatgcgg ggtggacttc acccacagcc gcctgagcaa cttgttgggc atccgcaagc 14940 ggcaaccctt ccaggagggc tttaggatca cctacgatga cctggagggt ggtaacattc 15000 ccgcactgtt ggatgtggac gcctaccagg caagcttaaa agatgacacc gaacagggcg 15060 gggatggcgc aggcggcggc aacaacagtg gcagcggcgc ggaagagaac tccaacgcgg 15120 cagccgcggc aatgcagccg gtggaggaca tgaacgatca tgccattcgc ggcgacacct 15180 ttgccacacg ggcggaggag aagcgcgctg aggccgaggc agcggcagaa gctgccgccc 15240 ccgctgcgca acccgaggtc gagaagcctc agaagaaacc ggtgatcaaa cccctgacag 15300 aggacagcaa gaaacgcagt tacaacctaa taagcaatga cagcaccttc acccagtacc 15360 gcagctggta ccttgcatac aactacggcg accctcagac cgggatccgc tcatggaccc 15420 tcctttgcac tcctgacgta acctgcggct cggagcaggt ctactggtcg ttgccagaca 15480 tgatgcaaga ccccgtgacc ttccgctcca cgagccagat cagcaacttt ccggtggtgg 15540 gcgccgagct gttgcccgtg cactccaaga gcttctacaa cgaccaggcc gtctactccc 15600 agctcatccg ccagtttacc tctctgaccc acgtgttcaa tcgctttccc gagaaccaga 15660 ttttggcgcg cccgccagcc cccaccatca ccaccgtcag tgaaaacgtt cctgctctca 15720 cagatcacgg gacgctaccg ctgcgcaaca gcatcggagg agtccagcga gtgaccatta 15780 ctgacgccag acgccgcacc tgcccctacg tttacaaggc cctgggcata gtctcgccgc 15840 gcgtcctatc gagccgcact ttttgagcaa acatgtccat ccttatatcg cccagcaata 15900 acacaggctg gggcctgcgc ttcccaagca agatgtttgg cggggcaaag aagcgctccg 15960 accaacaccc agtgcgcgtg cgcgggcact accgcgcgcc ctggggcgcg cacaaacgcg 16020 gccgcactgg gcgcaccacc gtcgatgacg ccattgacgc ggtggtggag gaggcgcgca 16080 actacacgcc cacgccgcca ccagtgtcca cagtggacgc ggccattcag accgtggtgc 16140 gcggagcccg gcgttatgct aaaatgaaga gacggcggag gcgcgtagca cgtcgccacc 16200 gccgccgacc cggcactgcc gcccaacgcg cggcggcggc cctgcttaac cgcgcacgtc 16260 gcaccggccg acgggcggcc atgcgggccg ctcgaaggct ggccgcgggt attgtcactg 16320 tgccccccag gtccaggcga cgagcggccg ccgcagcagc cgcggccatt agtgctatga 16380 ctcagggtcg caggggcaac gtgtactggg tgcgcgactc ggttagcggc ctgcgcgtgc 16440 ccgtgcgcac ccgccccccg cgcaactaga ttgcaagaaa aaactactta gactcgtact 16500 gttgtatgta tccagcggcg gcggcgcgca acgaagctat gtccaagcgc aaaatcaaag 16560 aagagatgct ccaggtcatc gcgccggaga tctatggccc cccgaagaag gaagagcagg 16620 attacaagcc ccgaaagcta aagcgggtca aaaagaaaaa gaaagatgat gatgatgatg 16680 aacttgacga cgaggtggaa ctgctgcacg caaccgcgcc caggcggcgg gtacagtgga 16740 aaggtcgacg cgtaagacgt gttttgcgac ccggcaccac cgtagttttt acgcccggtg 16800 agcgctccac ccgcacctac aagcgcgtgt atgatgaggt gtacggcgac gaggacctgc 16860 ttgagcaggc caacgagcgc ctcggggagt ttgcctacgg aaagcggcat aaggacatgt 16920 tggcgttgcc gctggacgag ggcaacccaa cacctagcct aaagcccgtg acactgcagc 16980 aggtgctgcc cacgcttgca ccgtccgaag aaaagcgcgg cctaaagcgc gagtctggtg 17040 acttggcacc caccgtgcag ctgatggtac ccaagcgcca gcgactggaa gatgtcttgg 17100 aaaaaatgac cgtggagcct gggctggagc ccgaggtccg cgtgcggcca atcaagcagg 17160 tggcaccggg actgggcgtg cagaccgtgg acgttcagat acccaccacc agtagcacta 17220 gtattgccac tgccacagag ggcatggaga cacaaacgtc cccggttgcc tcggcggtgg 17280 cagatgccgc ggtgcaggcg gccgctgcgg ccgcgtccaa aacctctacg gaggtgcaaa 17340 cggacccgtg gatgtttcgc gtttcagccc cccggcgccc gcgccgttcc aggaagtacg 17400 gcaccgccag cgcactactg cccgaatatg ccctacatcc ttccatcgcg cctacccccg 17460 gctatcgtgg ctacacctac cgccccagaa gacgagcgac tacccgacgc cgaaccacca 17520 ctggaacccg ccgccgccgt cgccgtcgcc agcccgtgct ggccccgatt tccgtgcgca 17580 gggtggctcg cgaaggaggc aggaccctgg tgctgccaac agcgcgctac caccccagca 17640 tcgtttaaaa gccggtcttt gtggttcttg cagatatggc cctcacctgc cgcctccgtt 17700 tcccggtgcc gggattccga ggaagaatgc accgtaggag gggcatggcc ggccacggcc 17760 tgacgggcgg catgcgtcgt gcgcaccacc ggcggcggcg cgcgtcgcac cgtcgcatgc 17820 gcggcggtat cctgcccctc cttattccac tgatcgccgc ggcgattggc gccgtgcccg 17880 gaattgcatc cgtggccttg caggcgcaga gacactgatt aaaaacaagt tgcatgtgga 17940 aaaatcaaaa taaaaagtct ggagtctcac gctcgcttgg tcctgtaact attttgtaga 18000 atggaagaca tcaactttgc gtctctggcc ccgcgacacg gctcgcgccc gttcatggga 18060 aactggcaag atatcggcac cagcaatatg agcggtggcg ccttcagctg gggctcgctg 18120 tggagcggca ttaaaaattt cggttccacc attaagaact atggcagcaa ggcctggaac 18180 agcagcacag gccagatgct gagggacaag ttgaaagagc aaaatttcca acaaaaggtg 18240 gtagatggcc tggcctctgg cattagcggg gtggtggacc tggccaacca ggcagtgcaa 18300 aataagatta acagtaagct tgatccccgc cctcccgtag aggagcctcc accggccgtg 18360 gagacagtgt ctccagaggg gcgtggcgaa aagcgtccgc ggcccgacag ggaagaaact 18420 ctggtgacgc aaatagatga gcctccctcg tacgaggagg cactaaagca aggcctgccc 18480 accacccgtc ccatcgcgcc catggctacc ggagtgctgg gccagcacac acctgtaacg 18540 ctggacctgc ctccccccgc tgacacccag cagaaacctg tgctgccagg gccgtccgcc 18600 gttgttgtaa cccgccctag ccgcgcgtcc ctgcgccgtg ccgccagcgg tccgcgatcg 18660 atgcggcccg tagccagtgg caactggcaa agcacactga acagcatcgt gggtctgggg 18720 gtgcaatccc tgaagcgccg acgatgcttc taaatagcta acgtgtcgta tgtgtcatgt 18780 atgcgtccat gtcgccgcca gaggagctgc tgagccgccg tgcgcccgct ttccaagatg 18840 gctacccctt cgatgatgcc gcagtggtct tacatgcaca tctcgggcca ggacgcctcg 18900 gagtacctga gccccgggct ggtgcagttt gcccgcgcca ccgagacgta cttcagcctg 18960 aataacaagt ttagaaaccc cacggtggca cctacgcacg acgtaaccac agaccggtcc 19020 cagcgtttga cgctgcggtt catccctgtg gaccgcgagg ataccgcgta ctcgtacaaa 19080 gcgcggttca ccctggctgt gggtgacaac cgtgtgcttg atatggcttc cacgtacttt 19140 gacatccgcg gcgtgctgga cagggggcct acttttaagc cctactccgg cactgcctac 19200 aacgctctag ctcccaaggg cgctcctaac tcctgtgagt gggaacaaac cgaagatagc 19260 ggccgggcag ttgccgagga tgaagaagag gaagatgaag atgaagaaga ggaagaagaa 19320 gagcaaaacg ctcgagatca ggctactaag aaaacacatg tctatgccca ggctcctttg 19380 tctggagaaa caattacaaa aagcgggcta caaataggat cagacaatgc agaaacacaa 19440 gctaaacctg tatacgcaga tccttcctat caaccagaac ctcaaattgg cgaatctcag 19500 tggaacgaag ctgatgctaa tgcggcagga gggagagtgc ttaaaaaaac aactcccatg 19560 aaaccatgct atggatctta tgccaggcct acaaatcctt ttggtggtca atccgttctg 19620 gttccggatg aaaaaggggt gcctcttcca aaggttgact tgcaattctt ctcaaatact 19680 acctctttga acgaccggca aggcaatgct actaaaccaa aagtggtttt gtacagtgaa 19740 gatgtaaata tggaaacccc agacacacat ctgtcttaca aacctggaaa aggtgatgaa 19800 aattctaaag ctatgttggg tcaacaatct atgccaaaca gacccaatta cattgctttc 19860 agggacaatt ttattggcct aatgtattat aacagcactg gcaacatggg tgttcttgct 19920 ggtcaggcat cgcagctaaa tgccgtggta gatttgcaag acagaaacac agagctgtcc 19980 tatcaactct tgcttgattc cataggtgat agaaccagat atttttctat gtggaatcag 20040 gctgtagaca gctatgatcc agatgttaga atcattgaaa accatggaac tgaggatgaa 20100 ttgccaaatt attgttttcc tcttgggggt attggggtaa ctgacaccta tcaagctatt 20160 aaggctaatg gcaatggctc aggcgataat ggagatacta catggacaaa agatgaaact 20220 tttgcaacac gtaatgaaat aggagtgggt aacaactttg ccatggaaat taacctaaat 20280 gccaacctat ggagaaattt cctttactcc aatattgcgc tgtacctgcc agacaagcta 20340 aaatacaacc ccaccaatgt ggaaatatct gacaacccca acacctacga ctacatgaac 20400 aagcgagtgg tggctcccgg gcttgtagac tgctacatta accttggggc gcgctggtct 20460 ctggactaca tggacaacgt taatcccttt aaccaccacc gcaatgcggg cctccgttat 20520 cgctccatgt tgttgggaaa cggccgctac gtgccctttc acattcaggt gccccaaaag 20580 ttttttgcca ttaaaaacct cctcctcctg ccaggctcat atacatatga atggaacttc 20640 aggaaggatg ttaacatggt tctgcagagc tctctgggaa acgatcttag agttgacggg 20700 gctagcatta agtttgacag catttgtctt tacgccacct tcttccccat ggcccacaac 20760 acggcctcca cgctggaagc catgctcaga aatgacacca acgaccagtc ctttaatgac 20820 tacctttccg ccgccaacat gctatacccc atacccgcca acgccaccaa cgtgcccatc 20880 tccatcccat cgcgcaactg ggcagcattt cgcggttggg ccttcacacg cttgaagaca 20940 aaggaaaccc cttccctggg atcaggctac gacccttact acacctactc tggctccata 21000 ccataccttg acggaacctt ctatcttaat cacaccttta agaaggtggc cattaccttt 21060 gactcttctg ttagctggcc gggcaacgac cgcctgctta ctcccaatga gtttgagatt 21120 aaacgctcag ttgacgggga gggctacaac gtagctcagt gcaacatgac caaggactgg 21180 ttcctggtgc agatgttggc caactacaat attggctacc agggcttcta cattccagaa 21240 agctacaagg accgcatgta ctcgttcttc agaaacttcc agcccatgag ccggcaagtg 21300 gttgacgata ctaaatacaa ggagtatcag caggttggaa ttcttcacca gcataacaac 21360 tcaggattcg taggctacct cgctcccacc atgcgcgagg gacaggctta ccccgccaac 21420 gtgccctacc cactaatagg caaaaccgcg gttgacagta ttacccagaa aaagtttctt 21480 tgcgatcgca ccctttggcg catcccattc tccagtaact ttatgtccat gggcgcactc 21540 acagacctgg gccaaaacct tctctacgcc aactccgccc acgcgctaga catgactttt 21600 gaggtggatc ccatggacga gcccaccctt ctttatgttt tgtttgaagt ctttgacgtg 21660 gtccgtgtgc accagccgca ccgcggcgtc atcgagaccg tgtacctgcg cacgcccttc 21720 tcggccggca acgccacaac ataaaagaag caagcaacat caacaacagc tgccgccatg 21780 ggctccagtg agcaggaact gaaagccatt gtcaaagatc ttggttgtgg gccatatttt 21840 ttgggcacct atgacaagcg ctttccaggc tttgtttctc cacacaagct cgcctgcgcc 21900 atagtcaata cggccggtcg cgagactggg ggcgtacact ggatggcctt tgcctggaac 21960 ccgcgctcaa aaacatgcta cctctttgag ccctttggct tttctgacca acgactcaag 22020 caggtttacc agtttgagta cgagtcactc ctgcgccgta gcgccattgc ttcttccccc 22080 gaccgctgta taacgctgga aaagtccacc caaagcgtgc aggggcccaa ctcggccgcc 22140 tgtggactat tctgctgcat gtttctccac gcctttgcca actggcccca aactcccatg 22200 gatcacaacc ccaccatgaa ccttattacc ggggtaccca actccatgct taacagtccc 22260 caggtacagc ccaccctgcg tcgcaaccag gaacagctct acagcttcct ggagcgccac 22320 tcgccctact tccgcagcca cagtgcgcag attaggagcg ccacttcttt ttgtcacttg 22380 aaaaacatgt aaaaataatg tactaggaga cactttcaat aaaggcaaat gtttttattt 22440 gtacactctc gggtgattat ttacccccca cccttgccgt ctgcgccgtt taaaaatcaa 22500 aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga tactggtgtt 22560 tagtgctcca cttaaactca ggcacaacca tccgcggcag ctcggtgaag ttttcactcc 22620 acaggctgcg caccatcacc aacgcgttta gcaggtcggg cgccgatatc ttgaagtcgc 22680 agttggggcc tccgccctgc gcgcgcgagt tgcgatacac agggttgcag cactggaaca 22740 ctatcagcgc cgggtggtgc acgctggcca gcacgctctt gtcggagatc agatccgcgt 22800 ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt tggtagctgc cttcccaaaa 22860 agggtgcatg cccaggcttt gagttgcact cgcaccgtag tggcatcaga aggtgaccgt 22920 gcccggtctg ggcgttagga tacagcgcct gcatgaaagc cttgatctgc ttaaaagcca 22980 cctgagcctt tgcgccttca gagaagaaca tgccgcaaga cttgccggaa aactgattgg 23040 ccggacaggc cgcgtcatgc acgcagcacc ttgcgtcggt gttggagatc tgcaccacat 23100 ttcggcccca ccggttcttc acgatcttgg ccttgctaga ctgctccttc agcgcgcgct 23160 gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc cttatttatc ataatgctcc 23220 cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg gtgcagccac aacgcgcagc 23280 ccgtgggctc gtggtgcttg taggttacct ctgcaaacga ctgcaggtac gcctgcagga 23340 atcgccccat catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc aacccgcggt 23400 gctcctcgtt tagccaggtc ttgcatacgg ccgccagagc ttccacttgg tcaggcagta 23460 gcttgaagtt tgcctttaga tcgttatcca cgtggtactt gtccatcaac gcgcgcgcag 23520 cctccatgcc cttctcccac gcagacacga tcggcaggct cagcgggttt atcaccgtgc 23580 tttcactttc cgcttcactg gactcttcct tttcctcttg cgtccgcata ccccgcgcca 23640 ctgggtcgtc ttcattcagc cgccgcaccg tgcgcttacc tcccttgccg tgcttgatta 23700 gcaccggtgg gttgctgaaa cccaccattt gtagcgccac atcttctctt tcttcctcgc 23760 tgtccacgat cacctctggg gatggcgggc gctcgggctt gggagagggg cgcttctttt 23820 tctttttgga cgcaatggcc aaatccgccg tcgaggtcga tggccgcggg ctgggtgtgc 23880 gcggcaccag cgcatcttgt gacgagtctt cttcgtcctc ggactcgaga cgccgcctca 23940 gccgcttttt tgggggcgcg cggggaggcg gcggcgacgg cgacggggac gacacgtcct 24000 ccatggttgg tggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt tcgcgctgct 24060 cctcttcccg actggccatt tccttctcct ataggcagaa aaagatcatg gagtcagtcg 24120 agaaggagga cagcctaacc gccccctttg agttcgccac caccgcctcc accgatgccg 24180 ccaacgcgcc taccaccttc cccgtcgagg cacccccgct tgaggaggag gaagtgatta 24240 tcgagcagga cccaggtttt gtaagcgaag acgacgagga tcgctcagta ccaacagagg 24300 ataaaaagca agaccaggac gacgcagagg caaacgagga acaagtcggg cggggggacc 24360 aaaggcatgg cgactaccta gatgtgggag acgacgtgct gttgaagcat ctgcagcgcc 24420 agtgcgccat tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc gccatagcgg 24480 atgtcagcct tgcctacgaa cgccacctgt tctcaccgcg cgtacccccc aaacgccaag 24540 aaaacggcac atgcgagccc aacccgcgcc tcaacttcta ccccgtattt gccgtgccag 24600 aggtgcttgc cacctatcac atctttttcc aaaactgcaa gataccccta tcctgccgtg 24660 ccaaccgcag ccgagcggac aagcagctgg ccttgcggca gggcgctgtc atacctgata 24720 tcgcctcgct cgacgaagtg ccaaaaatct ttgagggtct tggacgcgac gagaaacgcg 24780 cggcaaacgc tctgcaacaa gaaaacagcg aaaatgaaag tcactgtgga gtgctggtgg 24840 aacttgaggg tgacaacgcg cgcctagccg tgctgaaacg cagcatcgag gtcacccact 24900 ttgcctaccc ggcacttaac ctacccccca aggttatgag cacagtcatg agcgagctga 24960 tcgtgcgccg tgcacgaccc ctggagaggg atgcaaactt gcaagaacaa accgaggagg 25020 gcctacccgc agttggcgat gagcagctgg cgcgctggct tgagacgcgc gagcctgccg 25080 acttggagga gcgacgcaag ctaatgatgg ccgcagtgct tgttaccgtg gagcttgagt 25140 gcatgcagcg gttctttgct gacccggaga tgcagcgcaa gctagaggaa acgttgcact 25200 acacctttcg ccagggctac gtgcgccagg cctgcaaaat ttccaacgtg gagctctgca 25260 acctggtctc ctaccttgga attttgcacg aaaaccgcct cgggcaaaac gtgcttcatt 25320 ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac ttatttctgt 25380 gctacacctg gcaaacggcc atgggcgtgt ggcagcaatg cctggaggag cgcaacctaa 25440 aggagctgca gaagctgcta aagcaaaact tgaaggacct atggacggcc ttcaacgagc 25500 gctccgtggc cgcgcacctg gcggacatta tcttccccga acgcctgctt aaaaccctgc 25560 aacagggtct gccagacttc accagtcaaa gcatgttgca aaactttagg aactttatcc 25620 tagagcgttc aggaattctg cccgccacct gctgtgcgct tcctagcgac tttgtgccca 25680 ttaagtaccg tgaatgccct ccgccgcttt ggggtcactg ctaccttctg cagctagcca 25740 actaccttgc ctaccactcc gacatcatgg aagacgtgag cggtgacggc ctactggagt 25800 gtcactgtcg ctgcaaccta tgcaccccgc accgctccct ggtctgcaat tcgcaactgc 25860 ttagcgaaag tcaaattatc ggtacctttg agctgcaggg tccctcgcct gacgaaaagt 25920 ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac gtcggcttac cttcgcaaat 25980 ttgtacctga ggactaccac gcccacgaga ttaggttcta cgaagaccaa tcccgcccgc 26040 caaatgcgga gcttaccgcc tgcgtcatta cccagggcca catccttggc caattgcaag 26100 ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg acggggggtt tacctggacc 26160 cccagtccgg cgaggagctc aacccaatcc ccccgccgcc gcagccctat cagcagccgc 26220 gggcccttgc ttcccaggat ggcacccaaa aagaagctgc agctgccgcc gccgccaccc 26280 acggacgagg aggaatactg ggacagtcag gcagaggagg ttttggacga ggaggaggag 26340 atgatggaag actgggacag cctagacgaa gcttccgagg ccgaagaggt gtcagacgaa 26400 acaccgtcac cctcggtcgc attcccctcg ccggcgcccc agaaattggc aaccgttccc 26460 agcatcgcta caacctccgc tcctcaggcg ccgccggcac tgcctgttcg ccgacccaac 26520 cgtagatggg acaccactgg aaccagggcc ggtaagtcta agcagccgcc gccgttagcc 26580 caagagcaac aacagcgcca aggctaccgc tcgtggcgcg ggcacaagaa cgccatagtt 26640 gcttgcttgc aagactgtgg gggcaacatc tccttcgccc gccgctttct tctctaccat 26700 cacggcgtgg ccttcccccg taacatcctg cattactacc gtcatctcta cagcccctac 26760 tgcaccggcg gcagcggcag cggcagcaac agcagcggtc acacagaagc aaaggcgacc 26820 ggatagcaag actctgacaa agcccaagaa atccacagcg gcggcagcag caggaggagg 26880 agcgctgcgt ctggcgccca acgaacccgt atcgacccgc gagcttagaa ataggatttt 26940 tcccactctg tatgctatat ttcaacaaag caggggccaa gaacaagagc tgaaaataaa 27000 aaacaggtct ctgcgctccc tcacccgcag ctgcctgtat cacaaaagcg aagatcagct 27060 tcggcgcacg ctggaagacg cggaggctct cttcagcaaa tactgcgcgc tgactcttaa 27120 ggactagttt cgcgcccttt ctcaaattta agcgcgaaaa ctacgtcatc tccagcggcc 27180 acacccggcg ccagcacctg tcgtcagcgc cattatgagc aaggaaattc ccacgcccta 27240 catgtggagt taccagccac aaatgggact tgcggctgga gctgcccaag actactcaac 27300 ccgaataaac tacatgagcg cgggacccca catgatatcc cgggtcaacg gaatccgcgc 27360 ccaccgaaac cgaattctcc tcgaacaggc ggctattacc accacacctc gtaataacct 27420 taatccccgt agttggcccg ctgccctggt gtaccaggaa agtcccgctc ccaccactgt 27480 ggtacttccc agagacgccc aggccgaagt tcagatgact aactcagggg cgcagcttgc 27540 gggcggcttt cgtcacaggg tgcggtcgcc cgggcagggt ataactcacc tgaaaatcag 27600 agggcgaggt attcagctca acgacgagtc ggtgagctcc tctcttggtc tccgtccgga 27660 cgggacattt cagatcggcg gcgctggccg ctcttcattt acgccccgtc aggcgatcct 27720 aactctgcag acctcgtcct cggagccgcg ctccggaggc attggaactc tacaatttat 27780 tgaggagttc gtgccttcgg tttacttcaa ccccttttct ggacctcccg gccactaccc 27840 ggaccagttt attcccaact ttgacgcggt gaaagactcg gcggacggct acgactgaat 27900 gaccagtgga gaggcagagc gactgcgcct gacacacctc gaccactgcc gccgccacaa 27960 gtgctttgcc cgcggctccg gtgagttttg ttactttgaa ttgcccgaag agcatatcga 28020 gggcccggcg cacggcgtcc ggctcaccac ccaggtagag cttacacgta gcctgattcg 28080 ggagtttacc aagcgccccc tgctagtgga gcgggagcgg ggtccctgtg ttctgaccgt 28140 ggtttgcaac tgtcctaacc ctggattaca tcaagatctt tgttgtcatc tctgtgctga 28200 gtataataaa tacagaaatt agaatctact ggggctcctg tcgccatcct gtgaacgcca 28260 ccgtttttac ccacccaaag cagaccaaag caaacctcac ctccggtttg cacaagcggg 28320 ccaataagta ccttacctgg tactttaacg gctcttcatt tgtaatttac aacagtttcc 28380 agcgagacga agtaagtttg ccacacaacc ttctcggctt caactacacc gtcaagaaaa 28440 acaccaccac caccaccctc ctcacctgcc gggaacgtac gagtgcgtca ccggttgctg 28500 cgcccacacc tacagcctga gcgtaaccag acattactcc catttttcca aaacaggagg 28560 tgagctcaac tcccggaact caggtcaaaa aagcattttg cggggtgctg ggatttttta 28620 attaagtata tgagcaattc aagtaactct acaagcttgt ctaatttttc tggaattggg 28680 gtcggggtta tccttactct tgtaattctg tttattctta tactagcact tctgtgcctt 28740 agggttgccg cctgctgcac gcacgtttgt acctattgtc agctttttaa acgctggggg 28800 caacatccaa gatgaggtac atgattttag gcttgctcgc ccttgcggca gtctgcagcg 28860 ctgccaaaaa ggttgagttt aaggaaccag cttgcaatgt tacatttaaa tcagaagcta 28920 atgaatgcac tactcttata aaatgcacca cagaacatga aaagcttatt attcgccaca 28980 aagacaaaat tggcaagtat gctgtatatg ctatttggca gccaggtgac actaacgact 29040 ataatgtcac agtcttccaa ggtgaaaatc gtaaaacttt tatgtataaa tttccatttt 29100 atgaaatgtg cgatattacc atgtacatga gcaaacagta caagttgtgg cccccacaaa 29160 agtgtttaga gaacactggc accttttgtt ccaccgctct gcttattaca gcgcttgctt 29220 tggtatgtac cttactttat ctcaaataca aaagcagacg cagttttatt gatgaaaaga 29280 aaatgccttg attttccgct tgcttgtatt cccctggaca atttactcta tgtgggatat 29340 gctccaggcg ggcaagatta tacccacaac cttcaaatca aactttcctg gacgttagcg 29400 cctgatttct gccagcgcct gcactgcaaa tttgatcaaa cccagcttca gcttgcctgc 29460 tccagagatg accggctcaa ccatcgcgcc cacaacggac tatcgcaaca ccactgctac 29520 cggactaaca tctgccctaa atttacccca agttcatgcc tttgtcaatg actgggcgag 29580 cttggacatg tggtggtttt ccatagcgct tatgtttgtt tgccttatta ttatgtggct 29640 tatttgttgc ctaaagcgca gacgcgccag accccccatc tataggccta tcattgtgct 29700 caacccacac aatgaaaaaa ttcatagatt ggacggtctg aaaccatgtt ctcttctttt 29760 acagtatgat taaatgagac atgattcctc gagttcttat attattgacc cttgttgcgc 29820 ttttctgtgc gtgctctaca ttggccgcgg tcgctcacat cgaagtagat tgcatcccac 29880 ctttcacagt ttacctgctt tacggatttg tcacccttat cctcatctgc agcctcgtca 29940 ctgtagtcat cgccttcatt cagttcattg actgggtttg tgtgcgcatt gcgtacctca 30000 ggcaccatcc gcaatacaga gacaggacta tagctgatct tctcagaatt ctttaattat 30060 gaaacggagt gtcatttttg ttttgctgat tttttgcgcc ctacctgtgc tttgctccca 30120 aacctcagcg cctcccaaaa gacatatttc ctgcagattc actcaaatat ggaacattcc 30180 cagctgctac aacaaacaga gcgatttgtc agaagcctgg ttatacgcca tcatctctgt 30240 catggttttt tgcagtacca tttttgccct agccatatat ccataccttg acattggctg 30300 gaatgccata gatgccatga accaccctac tttcccagtg cccgctgtca taccactgca 30360 acaggttatt gccccaatca atcagcctcg ccccccttct cccaccccca ctgagattag 30420 ctactttaat ttgacaggtg gagatgactg aatctctaga tctagaattg gatggaatta 30480 acaccgaaca gcgcctacta gaaaggcgca aggcggcgtc cgagcgagaa cgcctaaaac 30540 aagaagttga agacatggtt aacctacacc agtgtaaaag aggtatcttt tgtgtggtca 30600 agcaggccaa acttacctac gaaaaaacca ctaccggcaa ccgcctcagc tacaagctac 30660 ccacccagcg ccaaaaactg gtgcttatgg tgggagaaaa acctatcacc gtcacccagc 30720 actcggcaga aacagagggc tgcctgcact tcccctatca gggtccagag gacctctgca 30780 ctcttattaa aaccatgtgt ggtattagag atcttattcc attcaactaa cataaacaca 30840 caataaatta cttacttaaa atcagtcagc aaatctttgt ccagcttatt cagcatcacc 30900 tcctttcctt cctcccaact ctggtatctc agccgccttt tagctgcaaa ctttctccaa 30960 agtttaaatg ggatgtcaaa ttcctcatgt tcttgtccct ccgcacccac tatcttcata 31020 ttgttgcaga tgaaacgcgc cagaccgtct gaagacacct tcaaccccgt gtatccatat 31080 gacacagaaa ccgggcctcc aactgtgccc tttcttaccc ctccatttgt ttcacccaat 31140 ggtttccaag aaagtccccc tggagttctc tctctacgcg tctccgaacc tttggacacc 31200 tcccacggca tgcttgcgct taaaatgggc agcggtctta ccctagacaa ggccggaaac 31260 ctcacctccc aaaatgtaac cactgttact cagccactta aaaaaacaaa gtcaaacata 31320 agtttggaca cctccgcacc acttacaatt acctcaggcg ccctaacagt ggcaaccacc 31380 gctcctctga tagttactag cggcgctctt agcgtacagt cacaagcccc actgaccgtg 31440 caagactcca aactaagcat tgctactaaa gggcccatta cagtgtcaga tggaaagcta 31500 gccctgcaaa catcagcccc cctctctggc agtgacagcg acacccttac tgtaactgca 31560 tcacccccgc taactactgc cacgggtagc ttgggcatta acatggaaga tcctatttat 31620 gtaaataatg gaaaaatagg aattaaaata agcggtcctt tgcaagtagc acaaaactcc 31680 gatacactaa cagtagttac tggaccaggt gtcaccgttg aacaaaactc ccttagaacc 31740 aaagttgcag gagctattgg ttatgattca tcaaacaaca tggaaattaa aacgggcggt 31800 ggcatgcgta taaataacaa cttgttaatt ctagatgtgg attacccatt tgatgctcaa 31860 acaaaactac gtcttaaact ggggcaggga cccctgtata ttaatgcatc tcataacttg 31920 gacataaact ataacagagg cctatacctt tttaatgcat caaacaatac taaaaaactg 31980 gaagttagca taaaaaaatc cagtggacta aactttgata atactgccat agctataaat 32040 gcaggaaagg gtctggagtt tgatacaaac acatctgagt ctccagatat caacccaata 32100 aaaactaaaa ttggctctgg cattgattac aatgaaaacg gtgccatgat tactaaactt 32160 ggagcgggtt taagctttga caactcaggg gccattacaa taggaaacaa aaatgatgac 32220 aaacttaccc tgtggacaac cccagaccca tctcctaact gcagaattca ttcagataat 32280 gactgcaaat ttactttggt tcttacaaaa tgtgggagtc aagtactagc tactgtagct 32340 gctttggctg tatctggaga tctttcatcc atgacaggca ccgttgcaag tgttagtata 32400 ttccttagat ttgaccaaaa cggtgttcta atggagaact cctcacttaa aaaacattac 32460 tggaacttta gaaatgggaa ctcaactaat gcaaatccat acacaaatgc agttggattt 32520 atgcctaacc ttctagccta tccaaaaacc caaagtcaaa ctgctaaaaa taacattgtc 32580 agtcaagttt acttgcatgg tgataaaact aaacctatga tacttaccat tacacttaat 32640 ggcactagtg aatccacaga aactagcgag gtaagcactt actctatgtc ttttacatgg 32700 tcctgggaaa gtggaaaata caccactgaa acttttgcta ccaactctta caccttctcc 32760 tacattgccc aggaataaag aatcgtgaac ctgttgcatg ttatgtttca acgtgtttat 32820 ttttcaattg cagaaaattt caagtcattt ttcattcagt agtatagccc caccaccaca 32880 tagcttatat tgatcaccgt accttaatca aactcacaga accctagtat tcaacctgcc 32940 acctccctcc caacacacag agtacacagt cctttctccc cggctggcct taaaaagcat 33000 catatcatgg gtaacagaca tattcttagg tgttatattc cacacggttt cctgtcgagc 33060 caaacgctca tcagtgatat taataaactc cccgggcagc tcgcttaagt tcatgtcgct 33120 gtccagctgc tgagccacag gctgctgtcc aacttgcggt tgctcaacgg gcggcgaagg 33180 ggaagtccac gcctacatgg gggtagagtc ataatcgtgc atcaggatag ggcggtggtg 33240 ctgcagcagc gcgcgaataa actgctgccg ccgccgctcc gtcctgcagg aatacaacat 33300 ggcagtggtc tcctcagcga tgattcgcac cgcccgcagc atgagacgcc ttgtcctccg 33360 ggcacagcag cgcaccctga tctcacttaa atcagcacag taactgcagc acagcaccac 33420 aatattgttc aaaatcccac agtgcaaggc gctgtatcca aagctcatgg cggggaccac 33480 agaacccacg tggccatcat accacaagcg caggtagatt aagtggcgac ccctcataaa 33540 cacgctggac ataaacatta cctcttttgg catgttgtaa ttcaccacct cccggtacca 33600 tataaacctc tgattaaaca tggcgccatc caccaccatc ctaaaccagc tggccaaaac 33660 ctgcccgccg gctatgcact gcagggaacc gggactggaa caatgacagt ggagagccca 33720 ggactcgtaa ccatggatca tcatgctcgt catgatatca atgttggcac aacacaggca 33780 cacgtgcata cacttcctca ggattacaag ctcctcccgc gtcagaacca tatcccaggg 33840 aacaacccat tcctgaatca gcgtaaatcc cacactgcag ggaagacctc gcacgtaact 33900 cacgttgtgc attgtcaaag tgttacattc gggcagcagc ggatgatcct ccagtatggt 33960 agcgcgggtc tctgtctcaa aaggaggtag gcgatcccta ctgtacggag tgcgccgaga 34020 caaccgagat cgtgttggtc gtagtgtcat gccaaatgga acgccggacg tagtcatatt 34080 tcctgaagca aaaccaggtg cgggcgtgac aaacagatct gcgtctccgg tctcgtcgct 34140 tagctcgctc tgtgtagtag ttgtagtata tccactctct caaagcatcc aggcgccccc 34200 tggcttcggg ttctatgtaa actccttcat gcgccgctgc cctgataaca tccaccaccg 34260 cagaataagc cacacccagc caacctacac attcgttctg cgagtcacac acgggaggag 34320 cgggaagagc tggaagaacc atgttttttt tttttttatt ccaaaagatt atccaaaacc 34380 tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc aaactctaca 34440 gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa aaggcaaact 34500 gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc ctctataaac 34560 attccagcac cttcaaccat gcccaaataa ttttcatctc gccaccttat caatatgtct 34620 ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag agcgccctcc 34680 accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca cagacctgta 34740 taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc cttcgcaggg 34800 ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc ccgccaggaa 34860 ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg ctaaccagcg 34920 tagcccctat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg ctgctcaaaa 34980 aatcaggcaa agcctcgcgc aaaaaagcaa gcacatcgta gtcatgctca tgcagataaa 35040 ggcaggtaag ttccggaacc accacagaaa aagacaccat ttttctctca aacatgtctg 35100 cgggttcctg cattaaacac aaaataaaat aacaaaaaaa aacatttaaa cattagaagc 35160 ctgtcttaca acaggaaaaa caacccttat aagcataaga cggactacgg ccatgccggc 35220 gtgaccgtaa aaaaactggt caccgtgatt aaaaagcacc accgacagtt cctcggtcat 35280 gtccggagtc ataatgtaag actcggtaaa cacatcaggt tggttaacat cggtcagtgc 35340 taaaaagcga ccgaaatagc ccgggggaat acatacccgc aggcgtagag acaacattac 35400 agcccccata ggaggtataa caaaattaat aggagagaaa aacacataaa cacctgaaaa 35460 accctcctgc ctaggcaaaa tagcaccctc ccgctccaga acaacataca gcgcttccac 35520 agcggcagcc ataacagtca gccttaccag taaaaaaacc tattaaaaaa caccactcga 35580 cacggcacca gctcaatcag tcacagtgta aaaagggcca agtacagagc gagtatatat 35640 aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg 35700 aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatct tcacttccgt 35760 tttcccacga tacgtcactt cccattttaa aaaaactaca attcccaata catgcaagtt 35820 actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac 35880 tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat gatgatg 35937 <210> 63 <211> 35938 <212> DNA <213> Human adenovirus type 5 <400> 63 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcaagtgt 4080 cttgctgtct ttatttaggg gttttgcgcg cgcggtaggc ccgggaccag cggtctcggt 4140 cgttgagggt cctgtgtatt ttttccagga cgtggtaaag gtgactctgg atgttcagat 4200 acatgggcat aagcccgtct ctggggtgga ggtagcacca ctgcagagct tcatgctgcg 4260 gggtggtgtt gtagatgatc cagtcgtagc aggagcgctg ggcgtggtgc ctaaaaatgt 4320 ctttcagtag caagctgatt gccaggggca ggcccttggt gtaagtgttt acaaagcggt 4380 taagctggga tgggtgcata cgtggggata tgagatgcat cttggactgt atttttaggt 4440 tggctatgtt cccagccata tccctccggg gattcatgtt gtgcagaacc accagcacag 4500 tgtatccggt gcacttggga aatttgtcat gtagcttaga aggaaatgcg tggaagaact 4560 tggagacgcc cttgtgacct ccaagatttt ccatgcattc gtccataatg atggcaatgg 4620 gcccacgggc ggcggcctgg gcgaagatat ttctgggatc actaacgtca tagttgtgtt 4680 ccaggatgag atcgtcatag gccattttta caaagcgcgg gcggagggtg ccagactgcg 4740 gtataatggt tccatccggc ccaggggcgt agttaccctc acagatttgc atttcccacg 4800 ctttgagttc agatgggggg atcatgtcta cctgcggggc gatgaagaaa acggtttccg 4860 gggtagggga gatcagctgg gaagaaagca ggttcctgag cagctgcgac ttaccgcagc 4920 cggtgggccc gtaaatcaca cctattaccg ggtgcaactg gtagttaaga gagctgcagc 4980 tgccgtcatc cctgagcagg ggggccactt cgttaagcat gtccctgact cgcatgtttt 5040 ccctgaccaa atccgccaga aggcgctcgc cgcccagcga tagcagttct tgcaaggaag 5100 caaagttttt caacggtttg agaccgtccg ccgtaggcat gcttttgagc gtttgaccaa 5160 gcagttccag gcggtcccac agctcggtca cctgctctac ggcatctcga tccagcatat 5220 ctcctcgttt cgcgggttgg ggcggctttc gctgtacggc agtagtcggt gctcgtccag 5280 acgggccagg gtcatgtctt tccacgggcg cagggtcctc gtcagcgtag tctgggtcac 5340 ggtgaagggg tgcgctccgg gctgcgcgct ggccagggtg cgcttgaggc tggtcctgct 5400 ggtgctgaag cgctgccggt cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt 5460 gtcatagtcc agcccctccg cggcgtggcc cttggcgcgc agcttgccct tggaggaggc 5520 gccgcacgag gggcagtgca gacttttgag ggcgtagagc ttgggcgcga gaaataccga 5580 ttccggggag taggcatccg cgccgcaggc cccgcagacg gtctcgcatt ccacgagcca 5640 ggtgagctct ggccgttcgg ggtcaaaaac caggtttccc ccatgctttt tgatgcgttt 5700 cttacctctg gtttccatga gccggtgtcc acgctcggtg acgaaaaggc tgtccgtgtc 5760 cccgtataca gacttgagag gcctgtcctc gagcggtgtt ccgcggtcct cctcgtatag 5820 aaactcggac cactctgaga caaaggctcg cgtccaggcc agcacgaagg aggctaagtg 5880 ggaggggtag cggtcgttgt ccactagggg gtccactcgc tccagggtgt gaagacacat 5940 gtcgccctct tcggcatcaa ggaaggtgat tggtttgtag gtgtaggcca cgtgaccggg 6000 tgttcctgaa ggggggctat aaaagggggt gggggcgcgt tcgtcctcac tctcttccgc 6060 atcgctgtct gcgagggcca gctgttgggg tgagtactcc ctctgaaaag cgggcatgac 6120 ttctgcgcta agattgtcag tttccaaaaa cgaggaggat ttgatattca cctggcccgc 6180 ggtgatgcct ttgagggtgg ccgcatccat ctggtcagaa aagacaatct ttttgttgtc 6240 aagcttggtg gcaaacgacc cgtagagggc gttggacagc aacttggcga tggagcgcag 6300 ggtttggttt ttgtcgcgat cggcgcgctc cttggccgcg atgtttagct gcacgtattc 6360 gcgcgcaacg caccgccatt cgggaaagac ggtggtgcgc tcgtcgggca ccaggtgcac 6420 gcgccaaccg cggttgtgca gggtgacaag gtcaacgctg gtggctacct ctccgcgtag 6480 gcgctcgttg gtccagcaga ggcggccgcc cttgcgcgag cagaatggcg gtagggggtc 6540 tagctgcgtc tcgtccgggg ggtctgcgtc cacggtaaag accccgggca gcaggcgcgc 6600 gtcgaagtag tctatcttgc atccttgcaa gtctagcgcc tgctgccatg cgcgggcggc 6660 aagcgcgcgc tcgtatgggt tgagtggggg accccatggc atggggtggg tgagcgcgga 6720 ggcgtacatg ccgcaaatgt cgtaaacgta gaggggctct ctgagtattc caagatatgt 6780 agggtagcat cttccaccgc ggatgctggc gcgcacgtaa tcgtatagtt cgtgcgaggg 6840 agcgaggagg tcgggaccga ggttgctacg ggcgggctgc tctgctcgga agactatctg 6900 cctgaagatg gcatgtgagt tggatgatat ggttggacgc tggaagacgt tgaagctggc 6960 gtctgtgaga cctaccgcgt cacgcacgaa ggaggcgtag gagtcgcgca gcttgttgac 7020 cagctcggcg gtgacctgca cgtctagggc gcagtagtcc agggtttcct tgatgatgtc 7080 atacttatcc tgtccctttt ttttccacag ctcgcggttg aggacaaact cttcgcggtc 7140 tttccagtac tcttggatcg gaaacccgtc ggcctccgaa cggtaagagc ctagcatgta 7200 gaactggttg acggcctggt aggcgcagca tcccttttct acgggtagcg cgtatgcctg 7260 cgcggccttc cggagcgagg tgtgggtgag cgcaaaggtg tccctgacca tgactttgag 7320 gtactggtat ttgaagtcag tgtcgtcgca tccgccctgc tcccagagca aaaagtccgt 7380 gcgctttttg gaacgcggat ttggcagggc gaaggtgaca tcgttgaaga gtatctttcc 7440 cgcgcgaggc ataaagttgc gtgtgatgcg gaagggtccc ggcacctcgg aacggttgtt 7500 aattacctgg gcggcgagca cgatctcgtc aaagccgttg atgttgtggc ccacaatgta 7560 aagttccaag aagcgcggga tgcccttgat ggaaggcaat tttttaagtt cctcgtaggt 7620 gagctcttca ggggagctga gcccgtgctc tgaaagggcc cagtctgcaa gatgagggtt 7680 ggaagcgacg aatgagctcc acaggtcacg ggccattagc atttgcaggt ggtcgcgaaa 7740 ggtcctaaac tggcgaccta tggccatttt ttctggggtg atgcagtaga aggtaagcgg 7800 gtcttgttcc cagcggtccc atccaaggtt cgcggctagg tctcgcgcgg cagtcactag 7860 aggctcatct ccgccgaact tcatgaccag catgaagggc acgagctgct tcccaaaggc 7920 ccccatccaa gtataggtct ctacatcgta ggtgacaaag agacgctcgg tgcgaggatg 7980 cgagccgatc gggaagaact ggatctcccg ccaccaattg gaggagtggc tattgatgtg 8040 gtgaaagtag aagtccctgc gacgggccga acactcgtgc tggcttttgt aaaaacgtgc 8100 gcagtactgg cagcggtgca cgggctgtac atcctgcacg aggttgacct gacgaccgcg 8160 cacaaggaag cagagtggga atttgagccc ctcgcctggc gggtttggct ggtggtcttc 8220 tacttcggct gcttgtcctt gaccgtctgg ctgctcgagg ggagttacgg tggatcggac 8280 caccacgccg cgcgagccca aagtccagat gtccgcgcgc ggcggtcgga gcttgatgac 8340 aacatcgcgc agatgggagc tgtccatggt ctggagctcc cgcggcgtca ggtcaggcgg 8400 gagctcctgc aggtttacct cgcatagacg ggtcagggcg cgggctagat ccaggtgata 8460 cctaatttcc aggggctggt tggtggcggc gtcgatggct tgcaagaggc cgcatccccg 8520 cggcgcgact acggtaccgc gcggcgggcg gtgggccgcg ggggtgtcct tggatgatgc 8580 atctaaaagc ggtgacgcgg gcgagccccc ggaggtaggg ggggctccgg acccgccggg 8640 agagggggca ggggcacgtc ggcgccgcgc gcgggcagga gctggtgctg cgcgcgtagg 8700 ttgctggcga acgcgacgac gcggcggttg atctcctgaa tctggcgcct ctgcgtgaag 8760 acgacgggcc cggtgagctt gagcctgaaa gagagttcga cagaatcaat ttcggtgtcg 8820 ttgacggcgg cctggcgcaa aatctcctgc acgtctcctg agttgtcttg ataggcgatc 8880 tcggccatga actgctcgat ctcttcctcc tggagatctc cgcgtccggc tcgctccacg 8940 gtggcggcga ggtcgttgga aatgcgggcc atgagctgcg agaaggcgtt gaggcctccc 9000 tcgttccaga cgcggctgta gaccacgccc ccttcggcat cgcgggcgcg catgaccacc 9060 tgcgcgagat tgagctccac gtgccgggcg aagacggcgt agtttcgcag gcgctgaaag 9120 aggtagttga gggtggtggc ggtgtgttct gccacgaaga agtacataac ccagcgtcgc 9180 aacgtggatt cgttgatatc ccccaaggcc tcaaggcgct ccatggcctc gtagaagtcc 9240 acggcgaagt tgaaaaactg ggagttgcgc gccgacacgg ttaactcctc ctccagaaga 9300 cggatgagct cggcgacagt gtcgcgcacc tcgcgctcaa aggctacagg ggcctcttct 9360 tcttcttcaa tctcctcttc cataagggcc tccccttctt cttcttctgg cggcggtggg 9420 ggagggggga cacggcggcg acgacggcgc accgggaggc ggtcgacaaa gcgctcgatc 9480 atctccccgc ggcgacggcg catggtctcg gtgacggcgc ggccgttctc gcgggggcgc 9540 agttggaaga cgccgcccgt catgtcccgg ttatgggttg gcggggggct gccatgcggc 9600 agggatacgg cgctaacgat gcatctcaac aattgttgtg taggtactcc gccgccgagg 9660 gacctgagcg agtccgcatc gaccggatcg gaaaacctct cgagaaaggc gtctaaccag 9720 tcacagtcgc aaggtaggct gagcaccgtg gcgggcggca gcgggcggcg gtcggggttg 9780 tttctggcgg aggtgctgct gatgatgtaa ttaaagtagg cggtcttgag acggcggatg 9840 gtcgacagaa gcaccatgtc cttgggtccg gcctgctgaa tgcgcaggcg gtcggccatg 9900 ccccaggctt cgttttgaca tcggcgcagg tctttgtagt agtcttgcat gagcctttct 9960 accggcactt cttcttctcc ttcctcttgt cctgcatctc ttgcatctat cgctgcggcg 10020 gcggcggagt ttggccgtag gtggcgccct cttcctccca tgcgtgtgac cccgaagccc 10080 ctcatcggct gaagcagggc taggtcggcg acaacgcgct cggctaatat ggcctgctgc 10140 acctgcgtga gggtagactg gaagtcatcc atgtccacaa agcggtggta tgcgcccgtg 10200 ttgatggtgt aagtgcagtt ggccataacg gaccagttaa cggtctggtg acccggctgc 10260 gagagctcgg tgtacctgag acgcgagtaa gccctcgagt caaatacgta gtcgttgcaa 10320 gtccgcacca ggtactggta tcccaccaaa aagtgcggcg gcggctggcg gtagaggggc 10380 cagcgtaggg tggccggggc tccgggggcg agatcttcca acataaggcg atgatatccg 10440 tagatgtacc tggacatcca ggtgatgccg gcggcggtgg tggaggcgcg cggaaagtcg 10500 cggacgcggt tccagatgtt gcgcagcggc aaaaagtgct ccatggtcgg gacgctctgg 10560 ccggtcaggc gcgcgcaatc gttgacgctc tagaccgtgc aaaaggagag cctgtaagcg 10620 ggcactcttc cgtggtctgg tggataaatt cgcaagggta tcatggcgga cgaccggggt 10680 tcgagccccg tatccggccg tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc 10740 caggtgtgcg acgtcagaca acgggggagt gctccttttg gcttccttcc aggcgcggcg 10800 gctgctgcgc tagctttttt ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa 10860 gcgaaagcat taagtggctc gctccctgta gccggagggt tattttccaa gggttgagtc 10920 gcgggacccc cggttcgagt ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc 10980 ccgtcatgca agaccccgct tgcaaattcc tccggaaaca gggacgagcc ccttttttgc 11040 ttttcccaga tgcatccggt gctgcggcag atgcgccccc ctcctcagca gcggcaagag 11100 caagagcagc ggcagacatg cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg 11160 acatccgcgg ttgacgcggc agcagatggt gattacgaac ccccgcggcg ccgggcccgg 11220 cactacctgg acttggagga gggcgagggc ctggcgcggc taggagcgcc ctctcctgag 11280 cggtacccaa gggtgcagct gaagcgtgat acgcgtgagg cgtacgtgcc gcggcagaac 11340 ctgtttcgcg accgcgaggg agaggagccc gaggagatgc gggatcgaaa gttccacgca 11400 gggcgcgagc tgcggcatgg cctgaatcgc gagcggttgc tgcgcgagga ggactttgag 11460 cccgacgcgc gaaccgggat tagtcccgcg cgcgcacacg tggcggccgc cgacctggta 11520 accgcatacg agcagacggt gaaccaggag attaactttc aaaaaagctt taacaaccac 11580 gtgcgtacgc ttgtggcgcg cgaggaggtg gctataggac tgatgcatct gtgggacttt 11640 gtaagcgcgc tggagcaaaa cccaaatagc aagccgctca tggcgcagct gttccttata 11700 gtgcagcaca gcagggacaa cgaggcattc agggatgcgc tgctaaacat agtagagccc 11760 gagggccgct ggctgctcga tttgataaac atcctgcaga gcatagtggt gcaggagcgc 11820 agcttgagcc tggctgacaa ggtggccgcc atcaactatt ccatgcttag cctgggcaag 11880 ttttacgccc gcaagatata ccatacccct tacgttccca tagacaagga ggtaaagatc 11940 gaggggttct acatgcgcat ggcgctgaag gtgcttacct tgagcgacga cctgggcgtt 12000 tatcgcaacg agcgcatcca caaggccgtg agcgtgagcc ggcggcgcga gctcagcgac 12060 cgcgagctga tgcacagcct gcaaagggcc ctggctggca cgggcagcgg cgatagagag 12120 gccgagtcct actttgacgc gggcgctgac ctgcgctggg ccccaagccg acgcgccctg 12180 gaggcagctg gggccggacc tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc 12240 ggcgtggagg aatatgacga ggacgatgag tacgagccag aggacggcga gtactaagcg 12300 gtgatgtttc tgatcagatg atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc 12360 agagccagcc gtccggcctt aactccacgg acgactggcg ccaggtcatg gaccgcatca 12420 tgtcgctgac tgcgcgcaat cctgacgcgt tccggcagca gccgcaggcc aaccggctct 12480 ccgcaattct ggaagcggtg gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg 12540 cgatcgtaaa cgcgctggcc gaaaacaggg ccatccggcc cgacgaggcc ggcctggtct 12600 acgacgcgct gcttcagcgc gtggctcgtt acaacagcgg caacgtgcag accaacctgg 12660 accggctggt gggggatgtg cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg 12720 gcaacctggg ctccatggtt gcactaaacg ccttcctgag tacacagccc gccaacgtgc 12780 cgcggggaca ggaggactac accaactttg tgagcgcact gcggctaatg gtgactgaga 12840 caccgcaaag tgaggtgtac cagtctgggc cagactattt tttccagacc agtagacaag 12900 gcctgcagac cgtaaacctg agccaggctt tcaaaaactt gcaggggctg tggggggtgc 12960 gggctcccac aggcgaccgc gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt 13020 tgctgctgct aatagcgccc ttcacggaca gtggcagcgt gtcccgggac acatacctag 13080 gtcacttgct gacactgtac cgcgaggcca taggtcaggc gcatgtggac gagcatactt 13140 tccaggagat tacaagtgtc agccgcgcgc tggggcagga ggacacgggc agcctggagg 13200 caaccctaaa ctacctgctg accaaccggc ggcagaagat cccctcgttg cacagtttaa 13260 acagcgagga ggagcgcatt ttgcgctacg tgcagcagag cgtgagcctt aacctgatgc 13320 gcgacggggt aacgcccagc gtggcgctgg acatgaccgc gcgcaacatg gaaccgggca 13380 tgtatgcctc aaaccggccg tttatcaacc gcctaatgga ctacttgcat cgcgcggccg 13440 ccgtgaaccc cgagtatttc accaatgcca tcttgaaccc gcactggcta ccgccccctg 13500 gtttctacac cgggggattc gaggtgcccg agggtaacga tggattcctc tgggacgaca 13560 tagacgacag cgtgttttcc ccgcaaccgc agaccctgct agagttgcaa cagcgcgagc 13620 aggcagaggc ggcgctgcga aaggaaagct tccgcaggcc aagcagcttg tccgatctag 13680 gcgctgcggc cccgcggtca gatgctagta gcccatttcc aagcttgata gggtctctta 13740 ccagcactcg caccacccgc ccgcgcctgc tgggcgagga ggagtaccta aacaactcgc 13800 tgctgcagcc gcagcgcgaa aaaaacctgc ctccggcatt tcccaacaac gggatagaga 13860 gcctagtgga caagatgagt agatggaaga cgtacgcgca ggagcacagg gacgtgccag 13920 gcccgcgccc gcccacccgt cgtcaaaggc acgaccgtca gcggggtctg gtgtgggagg 13980 acgatgactc ggcagacgac agcagcgtcc tggatttggg agggagtggc aacccgtttg 14040 cgcaccttcg ccccaggctg gggagaatgt tttaaaaaaa aaaaagcatg atgcaaaata 14100 aaaaactcac caaggccatg gcaccgagcg ttggttttct tgtattcccc ttagtatgcg 14160 gcgcgcggcg atgtatgagg aaggtcctcc tccctcctac gagagtgtgg tgagcgcggc 14220 gccagtggcg gcggcgctgg gttctccctt cgatgctccc ctggacccgc cgtttgtgcc 14280 tccgcggtac ctgcggccta ccggggggag aaacagcatc cgttactctg agttggcacc 14340 cctattcgac accacccgtg tgtacctggt ggacaacaag tcaacggatg tggcatccct 14400 gaactaccag aacgaccaca gcaactttct gaccacggtc attcaaaaca atgactacag 14460 cccgggggag gcaagcacac agaccatcaa tcttgacgac cggtcgcact ggggcggcga 14520 cctgaaaacc atcctgcata ccaacatgcc aaatgtgaac gagttcatgt ttaccaataa 14580 gtttaaggcg cgggtgatgg tgtcgcgctt gcctactaag gacaatcagg tggagctgaa 14640 atacgagtgg gtggagttca cgctgcccga gggcaactac tccgagacca tgaccataga 14700 ccttatgaac aacgcgatcg tggagcacta cttgaaagtg ggcagacaga acggggttct 14760 ggaaagcgac atcggggtaa agtttgacac ccgcaacttc agactggggt ttgaccccgt 14820 cactggtctt gtcatgcctg gggtatatac aaacgaagcc ttccatccag acatcatttt 14880 gctgccagga tgcggggtgg acttcaccca cagccgcctg agcaacttgt tgggcatccg 14940 caagcggcaa cccttccagg agggctttag gatcacctac gatgatctgg agggtggtaa 15000 cattcccgca ctgttggatg tggacgccta ccaggcgagc ttgaaagatg acaccgaaca 15060 gggcgggggt ggcgcaggcg gcagcaacag cagtggcagc ggcgcggaag agaactccaa 15120 cgcggcagcc gcggcaatgc agccggtgga ggacatgaac gatcatgcca ttcgcggcga 15180 cacctttgcc acacgggctg aggagaagcg cgctgaggcc gaagcagcgg ccgaagctgc 15240 cgcccccgct gcgcaacccg aggtcgagaa gcctcagaag aaaccggtga tcaaacccct 15300 gacagaggac agcaagaaac gcagttacaa cctaataagc aatgacagca ccttcaccca 15360 gtaccgcagc tggtaccttg catacaacta cggcgaccct cagaccggaa tccgctcatg 15420 gaccctgctt tgcactcctg acgtaacctg cggctcggag caggtctact ggtcgttgcc 15480 agacatgatg caagaccccg tgaccttccg ctccacgcgc cagatcagca actttccggt 15540 ggtgggcgcc gagctgttgc ccgtgcactc caagagcttc tacaacgacc aggccgtcta 15600 ctcccaactc atccgccagt ttacctctct gacccacgtg ttcaatcgct ttcccgagaa 15660 ccagattttg gcgcgcccgc cagcccccac catcaccacc gtcagtgaaa acgttcctgc 15720 tctcacagat cacgggacgc taccgctgcg caacagcatc ggaggagtcc agcgagtgac 15780 cattactgac gccagacgcc gcacctgccc ctacgtttac aaggccctgg gcatagtctc 15840 gccgcgcgtc ctatcgagcc gcactttttg agcaagcatg tccatcctta tatcgcccag 15900 caataacaca ggctggggcc tgcgcttccc aagcaagatg tttggcgggg ccaagaagcg 15960 ctccgaccaa cacccagtgc gcgtgcgcgg gcactaccgc gcgccctggg gcgcgcacaa 16020 acgcggccgc actgggcgca ccaccgtcga tgacgccatc gacgcggtgg tggaggaggc 16080 gcgcaactac acgcccacgc cgccaccagt gtccacagtg gacgcggcca ttcagaccgt 16140 ggtgcgcgga gcccggcgct atgctaaaat gaagagacgg cggaggcgcg tagcacgtcg 16200 ccaccgccgc cgacccggca ctgccgccca acgcgcggcg gcggccctgc ttaaccgcgc 16260 acgtcgcacc ggccgacggg cggccatgcg ggccgctcga aggctggccg cgggtattgt 16320 cactgtgccc cccaggtcca ggcgacgagc ggccgccgca gcagccgcgg ccattagtgc 16380 tatgactcag ggtcgcaggg gcaacgtgta ttgggtgcgc gactcggtta gcggcctgcg 16440 cgtgcccgtg cgcacccgcc ccccgcgcaa ctagattgca agaaaaaact acttagactc 16500 gtactgttgt atgtatccag cggcggcggc gcgcaacgaa gctatgtcca agcgcaaaat 16560 caaagaagag atgctccagg tcatcgcgcc ggagatctat ggccccccga agaaggaaga 16620 gcaggattac aagccccgaa agctaaagcg ggtcaaaaag aaaaagaaag atgatgatga 16680 tgaacttgac gacgaggtgg aactgctgca cgctaccgcg cccaggcgac gggtacagtg 16740 gaaaggtcga cgcgtaaaac gtgttttgcg acccggcacc accgtagtct ttacgcccgg 16800 tgagcgctcc acccgcacct acaagcgcgt gtatgatgag gtgtacggcg acgaggacct 16860 gcttgagcag gccaacgagc gcctcgggga gtttgcctac ggaaagcggc ataaggacat 16920 gctggcgttg ccgctggacg agggcaaccc aacacctagc ctaaagcccg taacactgca 16980 gcaggtgctg cccgcgcttg caccgtccga agaaaagcgc ggcctaaagc gcgagtctgg 17040 tgacttggca cccaccgtgc agctgatggt acccaagcgc cagcgactgg aagatgtctt 17100 ggaaaaaatg accgtggaac ctgggctgga gcccgaggtc cgcgtgcggc caatcaagca 17160 ggtggcgccg ggactgggcg tgcagaccgt ggacgttcag atacccacta ccagtagcac 17220 cagtattgcc accgccacag agggcatgga gacacaaacg tccccggttg cctcagcggt 17280 ggcggatgcc gcggtgcagg cggtcgctgc ggccgcgtcc aagacctcta cggaggtgca 17340 aacggacccg tggatgtttc gcgtttcagc cccccggcgc ccgcgcggtt cgaggaagta 17400 cggcgccgcc agcgcgctac tgcccgaata tgccctacat ccttccattg cgcctacccc 17460 cggctatcgt ggctacacct accgccccag aagacgagca actacccgac gccgaaccac 17520 cactggaacc cgccgccgcc gtcgccgtcg ccagcccgtg ctggccccga tttccgtgcg 17580 cagggtggct cgcgaaggag gcaggaccct ggtgctgcca acagcgcgct accaccccag 17640 catcgtttaa aagccggtct ttgtggttct tgcagatatg gccctcacct gccgcctccg 17700 tttcccggtg ccgggattcc gaggaagaat gcaccgtagg aggggcatgg ccggccacgg 17760 cctgacgggc ggcatgcgtc gtgcgcacca ccggcggcgg cgcgcgtcgc accgtcgcat 17820 gcgcggcggt atcctgcccc tccttattcc actgatcgcc gcggcgattg gcgccgtgcc 17880 cggaattgca tccgtggcct tgcaggcgca gagacactga ttaaaaacaa gttgcatgtg 17940 gaaaaatcaa aataaaaagt ctggactctc acgctcgctt ggtcctgtaa ctattttgta 18000 gaatggaaga catcaacttt gcgtctctgg ccccgcgaca cggctcgcgc ccgttcatgg 18060 gaaactggca agatatcggc accagcaata tgagcggtgg cgccttcagc tggggctcgc 18120 tgtggagcgg cattaaaaat ttcggttcca ccgttaagaa ctatggcagc aaggcctgga 18180 acagcagcac aggccagatg ctgagggata agttgaaaga gcaaaatttc caacaaaagg 18240 tggtagatgg cctggcctct ggcattagcg gggtggtgga cctggccaac caggcagtgc 18300 aaaataagat taacagtaag cttgatcccc gccctcccgt agaggagcct ccaccggccg 18360 tggagacagt gtctccagag gggcgtggcg aaaagcgtcc gcgccccgac agggaagaaa 18420 ctctggtgac gcaaatagac gagcctccct cgtacgagga ggcactaaag caaggcctgc 18480 ccaccacccg tcccatcgcg cccatggcta ccggagtgct gggccagcac acacccgtaa 18540 cgctggacct gcctcccccc gccgacaccc agcagaaacc tgtgctgcca ggcccgaccg 18600 ccgttgttgt aacccgtcct agccgcgcgt ccctgcgccg cgccgccagc ggtccgcgat 18660 cgttgcggcc cgtagccagt ggcaactggc aaagcacact gaacagcatc gtgggtctgg 18720 gggtgcaatc cctgaagcgc cgacgatgct tctgaatagc taacgtgtcg tatgtgtgtc 18780 atgtatgcgt ccatgtcgcc gccagaggag ctgctgagcc gccgcgcgcc cgctttccaa 18840 gatggctacc ccttcgatga tgccgcagtg gtcttacatg cacatctcgg gccaggacgc 18900 ctcggagtac ctgagccccg ggctggtgca gtttgcccgc gccaccgaga cgtacttcag 18960 cctgaataac aagtttagaa accccacggt ggcgcctacg cacgacgtga ccacagaccg 19020 gtcccagcgt ttgacgctgc ggttcatccc tgtggaccgt gaggatactg cgtactcgta 19080 caaggcgcgg ttcaccctag ctgtgggtga taaccgtgtg ctggacatgg cttccacgta 19140 ctttgacatc cgcggcgtgc tggacagggg ccctactttt aagccctact ctggcactgc 19200 ctacaacgcc ctggctccca agggtgcccc aaatccttgc gaatgggatg aagctgctac 19260 tgctcttgaa ataaacctag aagaagagga cgatgacaac gaagacgaag tagacgagca 19320 agctgagcag caaaaaactc acgtatttgg gcaggcgcct tattctggta taaatattac 19380 aaaggagggt attcaaatag gtgtcgaagg tcaaacacct aaatatgccg ataaaacatt 19440 tcaacctgaa cctcaaatag gagaatctca gtggtacgaa actgaaatta atcatgcagc 19500 tgggagagtc cttaaaaaga ctaccccaat gaaaccatgt tacggttcat atgcaaaacc 19560 cacaaatgaa aatggagggc aaggcattct tgtaaagcaa caaaatggaa agctagaaag 19620 tcaagtggaa atgcaatttt tctcaactac tgaggcgacc gcaggcaatg gtgataactt 19680 gactcctaaa gtggtattgt acagtgaaga tgtagatata gaaaccccag acactcatat 19740 ttcttacatg cccactatta aggaaggtaa ctcacgagaa ctaatgggcc aacaatctat 19800 gcccaacagg cctaattaca ttgcttttag ggacaatttt attggtctaa tgtattacaa 19860 cagcacgggt aatatgggtg ttctggcggg ccaagcatcg cagttgaatg ctgttgtaga 19920 tttgcaagac agaaacacag agctttcata ccagcttttg cttgattcca ttggtgatag 19980 aaccaggtac ttttctatgt ggaatcaggc tgttgacagc tatgatccag atgttagaat 20040 tattgaaaat catggaactg aagatgaact tccaaattac tgctttccac tgggaggtgt 20100 gattaataca gagactctta ccaaggtaaa acctaaaaca ggtcaggaaa atggatggga 20160 aaaagatgct acagaatttt cagataaaaa tgaaataaga gttggaaata attttgccat 20220 ggaaatcaat ctaaatgcca acctgtggag aaatttcctg tactccaaca tagcgctgta 20280 tttgcccgac aagctaaagt acagtccttc caacgtaaaa atttctgata acccaaacac 20340 ctacgactac atgaacaagc gagtggtggc tcccgggtta gtggactgct acattaacct 20400 tggagcacgc tggtcccttg actatatgga caacgtcaac ccatttaacc accaccgcaa 20460 tgctggcctg cgctaccgct caatgttgct gggcaatggt cgctatgtgc ccttccacat 20520 ccaggtgcct cagaagttct ttgccattaa aaacctcctt ctcctgccgg gctcatacac 20580 ctacgagtgg aacttcagga aggatgttaa catggttctg cagagctccc taggaaatga 20640 cctaagggtt gacggagcca gcattaagtt tgatagcatt tgcctttacg ccaccttctt 20700 ccccatggcc cacaacaccg cctccacgct tgaggccatg cttagaaacg acaccaacga 20760 ccagtccttt aacgactatc tctccgccgc caacatgctc taccctatac ccgccaacgc 20820 taccaacgtg cccatatcca tcccctcccg caactgggcg gctttccgcg gctgggcctt 20880 cacgcgcctt aagactaagg aaaccccatc actgggctcg ggctacgacc cttattacac 20940 ctactctggc tctataccct acctagatgg aaccttttac ctcaaccaca cctttaagaa 21000 ggtggccatt acctttgact cttctgtcag ctggcctggc aatgaccgcc tgcttacccc 21060 caacgagttt gaaattaagc gctcagttga cggggagggt tacaacgttg cccagtgtaa 21120 catgaccaaa gactggttcc tggtacaaat gctagctaac tacaacattg gctaccaggg 21180 cttctatatc ccagagagct acaaggaccg catgtactcc ttctttagaa acttccagcc 21240 catgagccgt caggtggtgg atgatactaa atacaaggac taccaacagg tgggcatcct 21300 acaccaacac aacaactctg gatttgttgg ctaccttgcc cccaccatgc gcgaaggaca 21360 ggcctaccct gctaacttcc cctatccgct tataggcaag accgcagttg acagcattac 21420 ccagaaaaag tttctttgcg atcgcaccct ttggcgcatc ccattctcca gtaactttat 21480 gtccatgggc gcactcacag acctgggcca aaaccttctc tacgccaact ccgcccacgc 21540 gctagacatg acttttgagg tggatcccat ggacgagccc acccttcttt atgttttgtt 21600 tgaagtcttt gacgtggtcc gtgtgcaccg gccgcaccgc ggcgtcatcg aaaccgtgta 21660 cctgcgcacg cccttctcgg ccggcaacgc cacaacataa agaagcaagc aacatcaaca 21720 acagctgccg ccatgggctc cagtgagcag gaactgaaag ccattgtcaa agatcttggt 21780 tgtgggccat attttttggg cacctatgac aagcgctttc caggctttgt ttctccacac 21840 aagctcgcct gcgccatagt caatacggcc ggtcgcgaga ctgggggcgt acactggatg 21900 gcctttgcct ggaacccgca ctcaaaaaca tgctacctct ttgagccctt tggcttttct 21960 gaccagcgac tcaagcaggt ttaccagttt gagtacgagt cactcctgcg ccgtagcgcc 22020 attgcttctt cccccgaccg ctgtataacg ctggaaaagt ccacccaaag cgtacagggg 22080 cccaactcgg ccgcctgtgg actattctgc tgcatgtttc tccacgcctt tgccaactgg 22140 ccccaaactc ccatggatca caaccccacc atgaacctta ttaccggggt acccaactcc 22200 atgctcaaca gtccccaggt acagcccacc ctgcgtcgca accaggaaca gctctacagc 22260 ttcctggagc gccactcgcc ctacttccgc agccacagtg cgcagattag gagcgccact 22320 tctttttgtc acttgaaaaa catgtaaaaa taatgtacta gagacacttt caataaaggc 22380 aaatgctttt atttgtacac tctcgggtga ttatttaccc ccacccttgc cgtctgcgcc 22440 gtttaaaaat caaaggggtt ctgccgcgca tcgctatgcg ccactggcag ggacacgttg 22500 cgatactggt gtttagtgct ccacttaaac tcaggcacaa ccatccgcgg cagctcggtg 22560 aagttttcac tccacaggct gcgcaccatc accaacgcgt ttagcaggtc gggcgccgat 22620 atcttgaagt cgcagttggg gcctccgccc tgcgcgcgcg agttgcgata cacagggttg 22680 cagcactgga acactatcag cgccgggtgg tgcacgctgg ccagcacgct cttgtcggag 22740 atcagatccg cgtccaggtc ctccgcgttg ctcagggcga acggagtcaa ctttggtagc 22800 tgccttccca aaaagggcgc gtgcccaggc tttgagttgc actcgcaccg tagtggcatc 22860 aaaaggtgac cgtgcccggt ctgggcgtta ggatacagcg cctgcataaa agccttgatc 22920 tgcttaaaag ccacctgagc ctttgcgcct tcagagaaga acatgccgca agacttgccg 22980 gaaaactgat tggccggaca ggccgcgtcg tgcacgcagc accttgcgtc ggtgttggag 23040 atctgcacca catttcggcc ccaccggttc ttcacgatct tggccttgct agactgctcc 23100 ttcagcgcgc gctgcccgtt ttcgctcgtc acatccattt caatcacgtg ctccttattt 23160 atcataatgc ttccgtgtag acacttaagc tcgccttcga tctcagcgca gcggtgcagc 23220 cacaacgcgc agcccgtggg ctcgtgatgc ttgtaggtca cctctgcaaa cgactgcagg 23280 tacgcctgca ggaatcgccc catcatcgtc acaaaggtct tgttgctggt gaaggtcagc 23340 tgcaacccgc ggtgctcctc gttcagccag gtcttgcata cggccgccag agcttccact 23400 tggtcaggca gtagtttgaa gttcgccttt agatcgttat ccacgtggta cttgtccatc 23460 agcgcgcgcg cagcctccat gcccttctcc cacgcagaca cgatcggcac actcagcggg 23520 ttcatcaccg taatttcact ttccgcttcg ctgggctctt cctcttcctc ttgcgtccgc 23580 ataccacgcg ccactgggtc gtcttcattc agccgccgca ctgtgcgctt acctcctttg 23640 ccatgcttga ttagcaccgg tgggttgctg aaacccacca tttgtagcgc cacatcttct 23700 ctttcttcct cgctgtccac gattacctct ggtgatggcg ggcgctcggg cttgggagaa 23760 gggcgcttct ttttcttctt gggcgcaatg gccaaatccg ccgccgaggt cgatggccgc 23820 gggctgggtg tgcgcggcac cagcgcgtct tgtgatgagt cttcctcgtc ctcggactcg 23880 atacgccgcc tcatccgctt ttttgggggc gcccggggag gcggcggcga cggggacggg 23940 gacgacacgt cctccatggt tgggggacgt cgcgccgcac cgcgtccgcg ctcgggggtg 24000 gtttcgcgct gctcctcttc ccgactggcc atttccttct cctataggca gaaaaagatc 24060 atggagtcag tcgagaagaa ggacagccta accgccccct ctgagttcgc caccaccgcc 24120 tccaccgatg ccgccaacgc gcctaccacc ttccccgtcg aggcaccccc gcttgaggag 24180 gaggaagtga ttatcgagca ggacccaggt tttgtaagcg aagacgacga ggaccgctca 24240 gtaccaacag aggataaaaa gcaagaccag gacaacgcag aggcaaacga ggaacaagtc 24300 gggcgggggg acgaaaggca tggcgactac ctagatgtgg gagacgacgt gctgttgaag 24360 catctgcagc gccagtgcgc cattatctgc gacgcgttgc aagagcgcag cgatgtgccc 24420 ctcgccatag cggatgtcag ccttgcctac gaacgccacc tattctcacc gcgcgtaccc 24480 cccaaacgcc aagaaaacgg cacatgcgag cccaacccgc gcctcaactt ctaccccgta 24540 tttgccgtgc cagaggtgct tgccacctat cacatctttt tccaaaactg caagataccc 24600 ctatcctgcc gtgccaaccg cagccgagcg gacaagcagc tggccttgcg gcagggcgct 24660 gtcatacctg atatcgcctc gctcaacgaa gtgccaaaaa tctttgaggg tcttggacgc 24720 gacgagaagc gcgcggcaaa cgctctgcaa caggaaaaca gcgaaaatga aagtcactct 24780 ggagtgttgg tggaactcga gggtgacaac gcgcgcctag ccgtactaaa acgcagcatc 24840 gaggtcaccc actttgccta cccggcactt aacctacccc ccaaggtcat gagcacagtc 24900 atgagtgagc tgatcgtgcg ccgtgcgcag cccctggaga gggatgcaaa tttgcaagaa 24960 caaacagagg agggcctacc cgcagttggc gacgagcagc tagcgcgctg gcttcaaacg 25020 cgcgagcctg ccgacttgga ggagcgacgc aaactaatga tggccgcagt gctcgttacc 25080 gtggagcttg agtgcatgca gcggttcttt gctgacccgg agatgcagcg caagctagag 25140 gaaacattgc actacacctt tcgacagggc tacgtacgcc aggcctgcaa gatctccaac 25200 gtggagctct gcaacctggt ctcctacctt ggaattttgc acgaaaaccg ccttgggcaa 25260 aacgtgcttc attccacgct caagggcgag gcgcgccgcg actacgtccg cgactgcgtt 25320 tacttatttc tatgctacac ctggcagacg gccatgggcg tttggcagca gtgcttggag 25380 gagtgcaacc tcaaggagct gcagaaactg ctaaagcaaa acttgaagga cctatggacg 25440 gccttcaacg agcgctccgt ggccgcgcac ctggcggaca tcattttccc cgaacgcctg 25500 cttaaaaccc tgcaacaggg tctgccagac ttcaccagtc aaagcatgtt gcagaacttt 25560 aggaacttta tcctagagcg ctcaggaatc ttgcccgcca cctgctgtgc acttcctagc 25620 gactttgtgc ccattaagta ccgcgaatgc cctccgccgc tttggggcca ctgctacctt 25680 ctgcagctag ccaactacct tgcctaccac tctgacataa tggaagacgt gagcggtgac 25740 ggtctactgg agtgtcactg tcgctgcaac ctatgcaccc cgcaccgctc cctggtttgc 25800 aattcgcagc tgcttaacga aagtcaaatt atcggtacct ttgagctgca gggtccctcg 25860 cctgacgaaa agtccgcggc tccggggttg aaactcactc cggggctgtg gacgtcggct 25920 taccttcgca aatttgtacc tgaggactac cacgcccacg agattaggtt ctacgaagac 25980 caatcccgcc cgccaaatgc ggagcttacc gcctgcgtca ttacccaggg ccacattctt 26040 ggccaattgc aagccatcaa caaagcccgc caagagtttc tgctacgaaa gggacggggg 26100 gtttacttgg acccccagtc cggcgaggag ctcaacccaa tccccccgcc gccgcagccc 26160 tatcagcagc agccgcgggc ccttgcttcc caggatggca cccaaaaaga agctgcagct 26220 gccgccgcca cccacggacg aggaggaata ctgggacagt caggcagagg aggttttgga 26280 cgaggaggag gaggacatga tggaagactg ggagagccta gacgaggaag cttccgaggt 26340 cgaagaggtg tcagacgaaa caccgtcacc ctcggtcgca ttcccctcgc cggcgcccca 26400 gaaatcggca accggttcca gcatggctac aacctccgct cctcaggcgc cgccggcact 26460 gcccgttcgc cgacccaacc gtagatggga caccactgga accagggccg gtaagtccaa 26520 gcagccgccg ccgttagccc aagagcaaca acagcgccaa ggctaccgct catggcgcgg 26580 gcacaagaac gccatagttg cttgcttgca agactgtggg ggcaacatct ccttcgcccg 26640 ccgctttctt ctctaccatc acggcgtggc cttcccccgt aacatcctgc attactaccg 26700 tcatctctac agcccatact gcaccggcgg cagcggcagc ggcagcaaca gcagcggcca 26760 cacagaagca aaggcgaccg gatagcaaga ctctgacaaa gcccaagaaa tccacagcgg 26820 cggcagcagc aggaggagga gcgctgcgtc tggcgcccaa cgaacccgta tcgacccgcg 26880 agcttagaaa caggattttt cccactctgt atgctatatt tcaacagagc aggggccaag 26940 aacaagagct gaaaataaaa aacaggtctc tgcgatccct cacccgcagc tgcctgtatc 27000 acaaaagcga agatcagctt cggcgcacgc tggaagacgc ggaggctctc ttcagtaaat 27060 actgcgcgct gactcttaag gactagtttc gcgccctttc tcaaatttaa gcgcgaaaac 27120 tacgtcatct ccagcggcca cacccggcgc cagcacctgt cgtcagcgcc attatgagca 27180 aggaaattcc cacgccctac atgtggagtt accagccaca aatgggactt gcggctggag 27240 ctgcccaaga ctactcaacc cgaataaact acatgagcgc gggaccccac atgatatccc 27300 gggtcaacgg aatccgcgcc caccgaaacc gaattctctt ggaacaggcg gctattacca 27360 ccacacctcg taataacctt aatccccgta gttggcccgc tgccctggtg taccaggaaa 27420 gtcccgctcc caccactgtg gtacttccca gagacgccca ggccgaagtt cagatgacta 27480 actcaggggc gcagcttgcg ggcggctttc gtcacagggt gcggtcgccc gggcagggta 27540 taactcacct gacaatcaga gggcgaggta ttcagctcaa cgacgagtcg gtgagctcct 27600 cgcttggtct ccgtccggac gggacatttc agatcggcgg cgccggccgt ccttcattca 27660 cgcctcgtca ggcaatccta actctgcaga cctcgtcctc tgagccgcgc tctggaggca 27720 ttggaactct gcaatttatt gaggagtttg tgccatcggt ctactttaac cccttctcgg 27780 gacctcccgg ccactatccg gatcaattta ttcctaactt tgacgcggta aaggactcgg 27840 cggacggcta cgactgaatg ttaagtggag aggcagagca actgcgcctg aaacacctgg 27900 tccactgtcg ccgccacaag tgctttgccc gcgactccgg tgagttttgc tactttgaat 27960 tgcccgagga tcatatcgag ggcccggcgc acggcgtccg gcttaccgcc cagggagagc 28020 ttgcccgtag cctgattcgg gagtttaccc agcgccccct gctagttgag cgggacaggg 28080 gaccctgtgt tctcactgtg atttgcaact gtcctaacct tggattacat caagatcttt 28140 gttgccatct ctgtgctgag tataataaat acagaaatta aaatatactg gggctcctat 28200 cgccatcctg taaacgccac cgtcttcacc cgcccaagca aaccaaggcg aaccttacct 28260 ggtactttta acatctctcc ctctgtgatt tacaacagtt tcaacccaga cggagtgagt 28320 ctacgagaga acctctccga gctcagctac tccatcagaa aaaacaccac cctccttacc 28380 tgccgggaac gtacgagtgc gtcaccggcc gctgcaccac acctaccgcc tgaccgtaaa 28440 ccagactttt tccggacaga cctcaataac tctgtttacc agaacaggag gtgagcttag 28500 aaaaccctta gggtattagg ccaaaggcgc agctactgtg gggtttatga acaattcaag 28560 caactctacg ggctattcta attcaggttt ctctagaatc ggggttgggg ttattctctg 28620 tcttgtgatt ctctttattc ttatactaac gcttctctgc ctaaggctcg ccgcctgctg 28680 tgtgcacatt tgcatttatt gtcagctttt taaacgctgg ggtcgccacc caagatgatt 28740 aggtacataa tcctaggttt actcaccctt gcgtcagccc acggtaccac ccaaaaggtg 28800 gattttaagg agccagcctg taatgttaca ttcgcagctg aagctaatga gtgcaccact 28860 cttataaaat gcaccacaga acatgaaaag ctgcttattc gccacaaaaa caaaattggc 28920 aagtatgctg tttatgctat ttggcagcca ggtgacacta cagagtataa tgttacagtt 28980 ttccagggta aaagtcataa aacttttatg tatacttttc cattttatga aatgtgcgac 29040 attaccatgt acatgagcaa acagtataag ttgtggcccc cacaaaattg tgtggaaaac 29100 actggcactt tctgctgcac tgctatgcta attacagtgc tcgctttggt ctgtacccta 29160 ctctatatta aatacaaaag cagacgcagc tttattgagg aaaagaaaat gccttaattt 29220 actaagttac aaagctaatg tcaccactaa ctgctttact cgctgcttgc aaaacaaatt 29280 caaaaagtta gcattataat tagaatagga tttaaacccc ccggtcattt cctgctcaat 29340 accattcccc tgaacaattg actctatgtg ggatatgctc cagcgctaca accttgaagt 29400 caggcttcct ggatgtcagc atctgacttt ggccagcacc tgtcccgcgg atttgttcca 29460 gtccaactac agcgacccac cctaacagag atgaccaaca caaccaacgc ggccgccgct 29520 accggactta catctaccac aaatacaccc caagtttctg cctttgtcaa taactgggat 29580 aacttgggca tgtggtggtt ctccatagcg cttatgtttg tatgccttat tattatgtgg 29640 ctcatctgct gcctaaagcg caaacgcgcc cgaccaccca tctatagtcc catcattgtg 29700 ctacacccaa acaatgatgg aatccataga ttggacggac tgaaacacat gttcttttct 29760 cttacagtat gattaaatga gacatgattc ctcgagtttt tatattactg acccttgttg 29820 cgcttttttg tgcgtgctcc acattggctg cggtttctca catcgaagta gactgcattc 29880 cagccttcac agtctatttg ctttacggat ttgtcaccct cacgctcatc tgcagcctca 29940 tcactgtggt catcgccttt atccagtgca ttgactgggt ctgtgtgcgc tttgcatatc 30000 tcagacacca tccccagtac agggacagga ctatagctga gcttcttaga attctttaat 30060 tatgaaattt actgtgactt ttctgctgat tatttgcacc ctatctgcgt tttgttcccc 30120 gacctccaag cctcaaagac atatatcatg cagattcact cgtatatgga atattccaag 30180 ttgctacaat gaaaaaagcg atctttccga agcctggtta tatgcaatca tctctgttat 30240 ggtgttctgc agtaccatct tagccctagc tatatatccc taccttgaca ttggctggaa 30300 acgaatagat gccatgaacc acccaacttt ccccgcgccc gctatgcttc cactgcaaca 30360 agttgttgcc ggcggctttg tcccagccaa tcagcctcgc cccacttctc ccacccccac 30420 tgaaatcagc tactttaatc taacaggagg agatgactga caccctagat ctagaaatgg 30480 acggaattat tacagagcag cgcctgctag aaagacgcag ggcagcggcc gagcaacagc 30540 gcatgaatca agagctccaa gacatggtta acttgcacca gtgcaaaagg ggtatctttt 30600 gtctggtaaa gcaggccaaa gtcacctacg acagtaatac caccggacac cgccttagct 30660 acaagttgcc aaccaagcgt cagaaattgg tggtcatggt gggagaaaag cccattacca 30720 taactcagca ctcggtagaa accgaaggct gcattcactc accttgtcaa ggacctgagg 30780 atctctgcac ccttattaag accctgtgcg gtctcaaaga tcttattccc tttaactaat 30840 aaaaaaaaat aataaagcat cacttactta aaatcagtta gcaaatttct gtccagttta 30900 ttcagcagca cctccttgcc ctcctcccag ctctggtatt gcagcttcct cctggctgca 30960 aactttctcc acaatctaaa tggaatgtca gtttcctcct gttcctgtcc atccgcaccc 31020 actatcttca tgttgttgca gatgaagcgc gcaagaccgt ctgaagatac cttcaacccc 31080 gtgtatccat atgacacgga aaccggtcct ccaactgtgc cttttcttac tcctcccttt 31140 gtatccccca atgggtttca agagagtccc cctggggtac tctctttgcg cctatccgaa 31200 cctctagtta cctccaatgg catgcttgcg ctcaaaatgg gcaacggcct ctctctggac 31260 gaggccggca accttacctc ccaaaatgta accactgtga gcccacctct caaaaaaacc 31320 aagtcaaaca taaacctgga aatatctgca cccctcacag ttacctcaga agccctaact 31380 gtggctgccg ccgcacctct aatggtcgcg ggcaacacac tcaccatgca atcacaggcc 31440 ccgctaaccg tgcacgactc caaacttagc attgccaccc aaggacccct cacagtgtca 31500 gaaggaaagc tagccctgca aacatcaggc cccctcacca ccaccgatag cagtaccctt 31560 actatcactg cctcaccccc tctaactact gccactggta gcttgggcat tgacttgaaa 31620 gagcccattt atacacaaaa tggaaaacta ggactaaagt acggggctcc tttgcatgta 31680 acagacgacc taaacacttt gaccgtagca actggtccag gtgtgactat taataatact 31740 tccttgcaaa ctaaagttac tggagccttg ggttttgatt cacaaggcaa tatgcaactt 31800 aatgtagcag gaggactaag gattgattct caaaacagac gccttatact tgatgttagt 31860 tatccgtttg atgctcaaaa ccaactaaat ctaagactag gacagggccc tctttttata 31920 aactcagccc acaacttgga tattaactac aacaaaggcc tttacttgtt tacagcttca 31980 aacaattcca aaaagcttga ggttaaccta agcactgcca aggggttgat gtttgacgct 32040 acagccatag ccattaatgc aggagatggg cttgaatttg gttcacctaa tgcaccaaac 32100 acaaatcccc tcaaaacaaa aattggccat ggcctagaat ttgattcaaa caaggctatg 32160 gttcctaaac taggaactgg ccttagtttt gacagcacag gtgccattac agtaggaaac 32220 aaaaataatg ataagctaac tttgtggacc acaccagctc catctcctaa ctgtagacta 32280 aatgcagaga aagatgctaa actcactttg gtcttaacaa aatgtggcag tcaaatactt 32340 gctacagttt cagttttggc tgttaaaggc agtttggctc caatatctgg aacagttcaa 32400 agtgctcatc ttattataag atttgacgaa aatggagtgc tactaaacaa ttccttcctg 32460 gacccagaat attggaactt tagaaatgga gatcttactg aaggcacagc ctatacaaac 32520 gctgttggat ttatgcctaa cctatcagct tatccaaaat ctcacggtaa aactgccaaa 32580 agtaacattg tcagtcaagt ttacttaaac ggagacaaaa ctaaacctgt aacactaacc 32640 attacactaa acggtacaca ggaaacagga gacacaactc caagtgcata ctctatgtca 32700 ttttcatggg actggtctgg ccacaactac attaatgaaa tatttgccac atcctcttac 32760 actttttcat acattgccca agaataaaga atcgtttgtg ttatgtttca acgtgtttat 32820 ttttcaattg cagaaaattt caagtcattt ttcattcagt agtatagccc caccaccaca 32880 tagcttatac agatcaccgt accttaatca aactcacaga accctagtat tcaacctgcc 32940 acctccctcc caacacacag agtacacagt cctttctccc cggctggcct taaaaagcat 33000 catatcatgg gtaacagaca tattcttagg tgttatattc cacacggttt cctgtcgagc 33060 caaacgctca tcagtgatat taataaactc cccgggcagc tcacttaagt tcatgtcgct 33120 gtccagctgc tgagccacag gctgctgtcc aacttgcggt tgcttaacgg gcggcgaagg 33180 agaagtccac gcctacatgg gggtagagtc ataatcgtgc atcaggatag ggcggtggtg 33240 ctgcagcagc gcgcgaataa actgctgccg ccgccgctcc gtcctgcagg aatacaacat 33300 ggcagtggtc tcctcagcga tgattcgcac cgcccgcagc ataaggcgcc ttgtcctccg 33360 ggcacagcag cgcaccctga tctcacttaa atcagcacag taactgcagc acagcaccac 33420 aatattgttc aaaatcccac agtgcaaggc gctgtatcca aagctcatgg cggggaccac 33480 agaacccacg tggccatcat accacaagcg caggtagatt aagtggcgac ccctcataaa 33540 cacgctggac ataaacatta cctcttttgg catgttgtaa ttcaccacct cccggtacca 33600 tataaacctc tgattaaaca tggcgccatc caccaccatc ctaaaccagc tggccaaaac 33660 ctgcccgccg gctatacact gcagggaacc gggactggaa caatgacagt ggagagccca 33720 ggactcgtaa ccatggatca tcatgctcgt catgatatca atgttggcac aacacaggca 33780 cacgtgcata cacttcctca ggattacaag ctcctcccgc gttagaacca tatcccaggg 33840 aacaacccat tcctgaatca gcgtaaatcc cacactgcag ggaagacctc gcacgtaact 33900 cacgttgtgc attgtcaaag tgttacattc gggcagcagc ggatgatcct ccagtatggt 33960 agcgcgggtt tctgtctcaa aaggaggtag acgatcccta ctgtacggag tgcgccgaga 34020 caaccgagat cgtgttggtc gtagtgtcat gccaaatgga acgccggacg tagtcatatt 34080 tcctgaagca aaaccaggtg cgggcgtgac aaacagatct gcgtctccgg tctcgccgct 34140 tagatcgctc tgtgtagtag ttgtagtata tccactctct caaagcatcc aggcgccccc 34200 tggcttcggg ttctatgtaa actccttcat gcgccgctgc cctgataaca tccaccaccg 34260 cagaataagc cacacccagc caacctacac attcgttctg cgagtcacac acgggaggag 34320 cgggaagagc tggaagaacc atgttttttt ttttattcca aaagattatc caaaacctca 34380 aaatgaagat ctattaagtg aacgcgctcc cctccggtgg cgtggtcaaa ctctacagcc 34440 aaagaacaga taatggcatt tgtaagatgt tgcacaatgg cttccaaaag gcaaacggcc 34500 ctcacgtcca agtggacgta aaggctaaac ccttcagggt gaatctcctc tataaacatt 34560 ccagcacctt caaccatgcc caaataattc tcatctcgcc accttctcaa tatatctcta 34620 agcaaatccc gaatattaag tccggccatt gtaaaaatct gctccagagc gccctccacc 34680 ttcagcctca agcagcgaat catgattgca aaaattcagg ttcctcacag acctgtataa 34740 gattcaaaag cggaacatta acaaaaatac cgcgatcccg taggtccctt cgcagggcca 34800 gctgaacata atcgtgcagg tctgcacgga ccagcgcggc cacttccccg ccaggaacca 34860 tgacaaaaga acccacactg attatgacac gcatactcgg agctatgcta accagcgtag 34920 ccccgatgta agcttgttgc atgggcggcg atataaaatg caaggtgctg ctcaaaaaat 34980 caggcaaagc ctcgcgcaaa aaagaaagca catcgtagtc atgctcatgc agataaaggc 35040 aggtaagctc cggaaccacc acagaaaaag acaccatttt tctctcaaac atgtctgcgg 35100 gtttctgcat aaacacaaaa taaaataaca aaaaaacatt taaacattag aagcctgtct 35160 tacaacagga aaaacaaccc ttataagcat aagacggact acggccatgc cggcgtgacc 35220 gtaaaaaaac tggtcaccgt gattaaaaag caccaccgac agctcctcgg tcatgtccgg 35280 agtcataatg taagactcgg taaacacatc aggttgattc acatcggtca gtgctaaaaa 35340 gcgaccgaaa tagcccgggg gaatacatac ccgcaggcgt agagacaaca ttacagcccc 35400 cataggaggt ataacaaaat taataggaga gaaaaacaca taaacacctg aaaaaccctc 35460 ctgcctaggc aaaatagcac cctcccgctc cagaacaaca tacagcgctt ccacagcggc 35520 agccataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac 35580 acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc gagtatatat 35640 aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg 35700 aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg tcacttccgt 35760 tttcccacgt tacgtaactt cccattttaa gaaaactaca attcccaaca catacaagtt 35820 actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac 35880 tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat tgatgatg 35938 <210> 64 <211> 150 <212> PRT <213> Human adenovirus type 2 <400> 64 Met Thr Thr Ser Gly Val Pro Phe Gly Met Thr Leu Arg Pro Thr Arg 1 5 10 15 Ser Arg Leu Ser Arg Arg Thr Pro Tyr Ser Arg Asp Arg Leu Pro Pro 20 25 30 Phe Glu Thr Glu Thr Arg Ala Thr Ile Leu Glu Asp His Pro Leu Leu 35 40 45 Pro Glu Cys Asn Thr Leu Thr Met His Asn Ala Trp Thr Ser Pro Ser 50 55 60 Pro Pro Val Glu Gln Pro Gln Val Gly Gln Gln Pro Val Ala Gln Gln 65 70 75 80 Leu Asp Ser Asp Met Asn Leu Ser Glu Leu Pro Gly Glu Phe Ile Asn 85 90 95 Ile Thr Asp Glu Arg Leu Ala Arg Gln Glu Thr Val Trp Asn Ile Thr 100 105 110 Pro Lys Asn Met Ser Val Thr His Asp Met Met Leu Phe Lys Ala Ser 115 120 125 Arg Gly Glu Arg Thr Val Tyr Ser Val Cys Trp Glu Gly Gly Gly Arg 130 135 140 Leu Asn Thr Arg Val Leu 145 150 <210> 65 <211> 91 <212> PRT <213> Human adenovirus type 5 <400> 65 Met Ile Pro Arg Val Phe Ile Leu Leu Thr Leu Val Ala Leu Phe Cys 1 5 10 15 Ala Cys Ser Thr Leu Ala Ala Val Ser His Ile Glu Val Asp Cys Ile 20 25 30 Pro Ala Phe Thr Val Tyr Leu Leu Tyr Gly Phe Val Thr Leu Thr Leu 35 40 45 Ile Cys Ser Leu Ile Thr Val Val Ile Ala Phe Ile Gln Cys Ile Asp 50 55 60 Trp Val Cys Val Arg Phe Ala Tyr Leu Arg His His Pro Gln Tyr Arg 65 70 75 80 Asp Arg Thr Ile Ala Glu Leu Leu Arg Ile Leu 85 90 <210> 66 <211> 132 <212> PRT <213> Human adenovirus type 5 <400> 66 Met Lys Phe Thr Val Thr Phe Leu Leu Ile Ile Cys Thr Leu Ser Ala 1 5 10 15 Phe Cys Ser Pro Thr Ser Lys Pro Gln Arg His Ile Ser Cys Arg Phe 20 25 30 Thr Arg Ile Trp Asn Ile Pro Ser Cys Tyr Asn Glu Lys Ser Asp Leu 35 40 45 Ser Glu Ala Trp Leu Tyr Ala Ile Ile Ser Val Met Val Phe Cys Ser 50 55 60 Thr Ile Leu Ala Leu Ala Ile Tyr Pro Tyr Leu Asp Ile Gly Trp Asn 65 70 75 80 Ala Ile Asp Ala Met Asn His Pro Thr Phe Pro Ala Pro Ala Met Leu 85 90 95 Pro Leu Gln Gln Val Val Ala Gly Gly Phe Val Pro Ala Asn Gln Pro 100 105 110 Arg Pro Pro Ser Pro Thr Pro Thr Glu Ile Ser Tyr Phe Asn Leu Thr 115 120 125 Gly Gly Asp Asp 130 <210> 67 <211> 128 <212> PRT <213> Human adenovirus type 5 <400> 67 Met Thr Asp Thr Leu Asp Leu Glu Met Asp Gly Ile Ile Thr Glu Gln 1 5 10 15 Arg Leu Leu Glu Arg Arg Arg Ala Ala Ala Glu Gln Gln Arg Met Asn 20 25 30 Gln Glu Leu Gln Asp Met Val Asn Leu His Gln Cys Lys Arg Gly Ile 35 40 45 Phe Cys Leu Val Lys Gln Ala Lys Val Thr Tyr Asp Ser Asn Thr Thr 50 55 60 Gly His Arg Leu Ser Tyr Lys Leu Pro Thr Lys Arg Gln Lys Leu Val 65 70 75 80 Val Met Val Gly Glu Lys Pro Ile Thr Ile Thr Gln His Ser Val Glu 85 90 95 Thr Glu Gly Cys Ile His Ser Pro Cys Gln Gly Pro Glu Asp Leu Cys 100 105 110 Thr Leu Ile Lys Thr Leu Cys Gly Leu Lys Asp Leu Ile Pro Phe Asn 115 120 125 <210> 68 <211> 36717 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO440) <400> 68 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagatggaa gcggagctac taacttcagc ctgctgaagc 3540 aggctggtga cgtcgaggag aatcctggcc caatggtgag caaaggcgaa gagctgttca 3600 ccggcgtggt gcccatcctg gtggagctgg acggcgacgt gaacggccac aagttcagcg 3660 tgagcggcga gggcgagggc gacgccacct acggcaagct gaccctgaag ctgctgtgca 3720 ccaccggcaa gctgcccgtg ccctggccca ccctggtgac caccctgggc tacggcgtgc 3780 agtgcttcgc ccggtacccc gaccacatga agcagcacga cttcttcaag agcgccatgc 3840 ccgagggcta cgtgcaggag cggaccatct tcttcaagga cgacggcaac tacaagaccc 3900 gggccgaggt gaagttcgag ggcgacaccc tggtgaaccg gatcgagctg aagggcatcg 3960 acttcaagga ggacggcaac atcctgggcc acaagctgga gtacaactac aacagccaca 4020 acgtgtacat caccgccgac aagcagaaga acggcatcaa ggccaacttc aagatccggc 4080 acaacatcga ggacggcggc gtgcagctgg ccgaccacta ccagcagaac acccccatcg 4140 gcgacggccc cgtgctgctg cccgacaacc actacctgag ctaccagagc gccctgttca 4200 aggaccccaa cgagaagcgg gaccacatgg tgctgctgga gttcctgacc gccgccggca 4260 tcaccgaggg catgaacgag ctctataagt gaggtactga aatgtgtggg cgtggcttaa 4320 gggtgggaaa gaatatataa ggtgggggtc ttatgtagtt ttgtatctgt tttgcagcag 4380 ccgccgccgc catgagcacc aactcgtttg atggaagcat tgtgagctca tatttgacaa 4440 cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat gggctccagc attgatggtc 4500 gccccgtcct gcccgcaaac tctactacct tgacctacga gaccgtgtct ggaacgccgt 4560 tggagactgc agcctccgcc gccgcttcag ccgctgcagc caccgcccgc gggattgtga 4620 ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc ttcccgttca tccgcccgcg 4680 atgacaagtt gacggctctt ttggcacaat tggattcttt gacccgggaa cttaatgtcg 4740 tttctcagca gctgttggat ctgcgccagc aggtttctgc cctgaaggct tcctcccctc 4800 ccaatgcggt ttaaaacata aataaaaaac cagactctgt ttggatttgg atcaagcata 4860 agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg taggcccggg accagcggtc 4920 tcggtcgttg agggtcctgt gtattttttc caggacgtgg taaaggtgac tctggatgtt 4980 cagatacatg ggcataagcc cgtctctggg gtggaggtag caccactgca gagcttcatg 5040 ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag cgctgggcgt ggtgcctaaa 5100 aatgtctttc agtagcaagc tgattgccag gggcaggccc ttggtgtaag tgtttacaaa 5160 gcggttaagc tgggatgggt gcatacgtgg ggatatgaga tgcatcttgg actgtatttt 5220 taggttggct atgttcccag ccatatccct ccggggattc atgttgtgca gaaccaccag 5280 cacagtgtat ccggtgcact tgggaaattt gtcatgtagc ttagaaggaa atgcgtggaa 5340 gaacttggag acgcccttgt gacctccaag attttccatg cattcgtcca taatgatggc 5400 aatgggccca cgggcggcgg cctgggcgaa gatatttctg ggatcactaa cgtcatagtt 5460 gtgttccagg atgagatcgt cataggccat ttttacaaag cgcgggcgga gggtgccaga 5520 ctgcggtata atggttccat ccggcccagg ggcgtagtta ccctcacaga tttgcatttc 5580 ccacgctttg agttcagatg gggggatcat gtctacctgc ggggcgatga agaaaacggt 5640 ttccggggta ggggagatca gctgggaaga aagcaggttc ctgagcagct gcgacttacc 5700 gcagccggtg ggcccgtaaa tcacacctat taccggctgc aactggtagt taagagagct 5760 gcagctgccg tcatccctga gcaggggggc cacttcgtta agcatgtccc tgactcgcat 5820 gttttccctg accaaatccg ccagaaggcg ctcgccgccc agcgatagca gttcttgcaa 5880 ggaagcaaag tttttcaacg gtttgagacc gtccgccgta ggcatgcttt tgagcgtttg 5940 accaagcagt tccaggcggt cccacagctc ggtcacctgc tctacggcat ctcgatccag 6000 catatctcct cgtttcgcgg gttggggcgg ctttcgctgt acggcagtag tcggtgctcg 6060 tccagacggg ccagggtcat gtctttccac gggcgcaggg tcctcgtcag cgtagtctgg 6120 gtcacggtga aggggtgcgc tccgggctgc gcgctggcca gggtgcgctt gaggctggtc 6180 ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt cggccaggta gcatttgacc 6240 atggtgtcat agtccagccc ctccgcggcg tggcccttgg cgcgcagctt gcccttggag 6300 gaggcgccgc acgaggggca gtgcagactt ttgagggcgt agagcttggg cgcgagaaat 6360 accgattccg gggagtaggc atccgcgccg caggccccgc agacggtctc gcattccacg 6420 agccaggtga gctctggccg ttcggggtca aaaaccaggt ttcccccatg ctttttgatg 6480 cgtttcttac ctctggtttc catgagccgg tgtccacgct cggtgacgaa aaggctgtcc 6540 gtgtccccgt atacagactt gagaggcctg tcctcgagcg gtgttccgcg gtcctcctcg 6600 tatagaaact cggaccactc tgagacaaag gctcgcgtcc aggccagcac gaaggaggct 6660 aagtgggagg ggtagcggtc gttgtccact agggggtcca ctcgctccag ggtgtgaaga 6720 cacatgtcgc cctcttcggc atcaaggaag gtgattggtt tgtaggtgta ggccacgtga 6780 ccgggtgttc ctgaaggggg gctataaaag ggggtggggg cgcgttcgtc ctcactctct 6840 tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt actccctctg aaaagcgggc 6900 atgacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat attcacctgg 6960 cccgcggtga tgcctttgag ggtggccgca tccatctggt cagaaaagac aatctttttg 7020 ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg acagcaactt ggcgatggag 7080 cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg ccgcgatgtt tagctgcacg 7140 tattcgcgcg caacgcaccg ccattcggga aagacggtgg tgcgctcgtc gggcaccagg 7200 tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa cgctggtggc tacctctccg 7260 cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc gcgagcagaa tggcggtagg 7320 gggtctagct gcgtctcgtc cggggggtct gcgtccacgg taaagacccc gggcagcagg 7380 cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta gcgcctgctg ccatgcgcgg 7440 gcggcaagcg cgcgctcgta tgggttgagt gggggacccc atggcatggg gtgggtgagc 7500 gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg gctctctgag tattccaaga 7560 tatgtagggt agcatcttcc accgcggatg ctggcgcgca cgtaatcgta tagttcgtgc 7620 gagggagcga ggaggtcggg accgaggttg ctacgggcgg gctgctctgc tcggaagact 7680 atctgcctga agatggcatg tgagttggat gatatggttg gacgctggaa gacgttgaag 7740 ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg cgtaggagtc gcgcagcttg 7800 ttgaccagct cggcggtgac ctgcacgtct agggcgcagt agtccagggt ttccttgatg 7860 atgtcatact tatcctgtcc cttttttttc cacagctcgc ggttgaggac aaactcttcg 7920 cggtctttcc agtactcttg gatcggaaac ccgtcggcct ccgaacggta agagcctagc 7980 atgtagaact ggttgacggc ctggtaggcg cagcatccct tttctacggg tagcgcgtat 8040 gcctgcgcgg ccttccggag cgaggtgtgg gtgagcgcaa aggtgtccct gaccatgact 8100 ttgaggtact ggtatttgaa gtcagtgtcg tcgcatccgc cctgctccca gagcaaaaag 8160 tccgtgcgct ttttggaacg cggatttggc agggcgaagg tgacatcgtt gaagagtatc 8220 tttcccgcgc gaggcataaa gttgcgtgtg atgcggaagg gtcccggcac ctcggaacgg 8280 ttgttaatta cctgggcggc gagcacgatc tcgtcaaagc cgttgatgtt gtggcccaca 8340 atgtaaagtt ccaagaagcg cgggatgccc ttgatggaag gcaatttttt aagttcctcg 8400 taggtgagct cttcagggga gctgagcccg tgctctgaaa gggcccagtc tgcaagatga 8460 gggttggaag cgacgaatga gctccacagg tcacgggcca ttagcatttg caggtggtcg 8520 cgaaaggtcc taaactggcg acctatggcc attttttctg gggtgatgca gtagaaggta 8580 agcgggtctt gttcccagcg gtcccatcca aggttcgcgg ctaggtctcg cgcggcagtc 8640 actagaggct catctccgcc gaacttcatg accagcatga agggcacgag ctgcttccca 8700 aaggccccca tccaagtata ggtctctaca tcgtaggtga caaagagacg ctcggtgcga 8760 ggatgcgagc cgatcgggaa gaactggatc tcccgccacc aattggagga gtggctattg 8820 atgtggtgaa agtagaagtc cctgcgacgg gccgaacact cgtgctggct tttgtaaaaa 8880 cgtgcgcagt actggcagcg gtgcacgggc tgtacatcct gcacgaggtt gacctgacga 8940 ccgcgcacaa ggaagcagag tgggaatttg agcccctcgc ctggcgggtt tggctggtgg 9000 tcttctactt cggctgcttg tccttgaccg tctggctgct cgaggggagt tacggtggat 9060 cggaccacca cgccgcgcga gcccaaagtc cagatgtccg cgcgcggcgg tcggagcttg 9120 atgacaacat cgcgcagatg ggagctgtcc atggtctgga gctcccgcgg cgtcaggtca 9180 ggcgggagct cctgcaggtt tacctcgcat agacgggtca gggcgcgggc tagatccagg 9240 tgatacctaa tttccagggg ctggttggtg gcggcgtcga tggcttgcaa gaggccgcat 9300 ccccgcggcg cgactacggt accgcgcggc gggcggtggg ccgcgggggt gtccttggat 9360 gatgcatcta aaagcggtga cgcgggcgag cccccggagg tagggggggc tccggacccg 9420 ccgggagagg gggcaggggc acgtcggcgc cgcgcgcggg caggagctgg tgctgcgcgc 9480 gtaggttgct ggcgaacgcg acgacgcggc ggttgatctc ctgaatctgg cgcctctgcg 9540 tgaagacgac gggcccggtg agcttgaacc tgaaagagag ttcgacagaa tcaatttcgg 9600 tgtcgttgac ggcggcctgg cgcaaaatct cctgcacgtc tcctgagttg tcttgatagg 9660 cgatctcggc catgaactgc tcgatctctt cctcctggag atctccgcgt ccggctcgct 9720 ccacggtggc ggcgaggtcg ttggaaatgc gggccatgag ctgcgagaag gcgttgaggc 9780 ctccctcgtt ccagacgcgg ctgtagacca cgcccccttc ggcatcgcgg gcgcgcatga 9840 ccacctgcgc gagattgagc tccacgtgcc gggcgaagac ggcgtagttt cgcaggcgct 9900 gaaagaggta gttgagggtg gtggcggtgt gttctgccac gaagaagtac ataacccagc 9960 gtcgcaacgt ggattcgttg atatccccca aggcctcaag gcgctccatg gcctcgtaga 10020 agtccacggc gaagttgaaa aactgggagt tgcgcgccga cacggttaac tcctcctcca 10080 gaagacggat gagctcggcg acagtgtcgc gcacctcgcg ctcaaaggct acaggggcct 10140 cttcttcttc ttcaatctcc tcttccataa gggcctcccc ttcttcttct tctggcggcg 10200 gtgggggagg ggggacacgg cggcgacgac ggcgcaccgg gaggcggtcg acaaagcgct 10260 cgatcatctc cccgcggcga cggcgcatgg tctcggtgac ggcgcggccg ttctcgcggg 10320 ggcgcagttg gaagacgccg cccgtcatgt cccggttatg ggttggcggg gggctgccat 10380 gcggcaggga tacggcgcta acgatgcatc tcaacaattg ttgtgtaggt actccgccgc 10440 cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa cctctcgaga aaggcgtcta 10500 accagtcaca gtcgcaaggt aggctgagca ccgtggcggg cggcagcggg cggcggtcgg 10560 ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa gtaggcggtc ttgagacggc 10620 ggatggtcga cagaagcacc atgtccttgg gtccggcctg ctgaatgcgc aggcggtcgg 10680 ccatgcccca ggcttcgttt tgacatcggc gcaggtcttt gtagtagtct tgcatgagcc 10740 tttctaccgg cacttcttct tctccttcct cttgtcctgc atctcttgca tctatcgctg 10800 cggcggcggc ggagtttggc cgtaggtggc gccctcttcc tcccatgcgt gtgaccccga 10860 agcccctcat cggctgaagc agggctaggt cggcgacaac gcgctcggct aatatggcct 10920 gctgcacctg cgtgagggta gactggaagt catccatgtc cacaaagcgg tggtatgcgc 10980 ccgtgttgat ggtgtaagtg cagttggcca taacggacca gttaacggtc tggtgacccg 11040 gctgcgagag ctcggtgtac ctgagacgcg agtaagccct cgagtcaaat acgtagtcgt 11100 tgcaagtccg caccaggtac tggtatccca ccaaaaagtg cggcggcggc tggcggtaga 11160 ggggccagcg tagggtggcc ggggctccgg gggcgagatc ttccaacata aggcgatgat 11220 atccgtagat gtacctggac atccaggtga tgccggcggc ggtggtggag gcgcgcggaa 11280 agtcgcggac gcggttccag atgttgcgca gcggcaaaaa gtgctccatg gtcgggacgc 11340 tctggccggt caggcgcgcg caatcgttga cgctctagac cgtgcaaaag gagagcctgt 11400 aagcgggcac tcttccgtgg tctggtggat aaattcgcaa gggtatcatg gcggacgacc 11460 ggggttcgag ccccgtatcc ggccgtccgc cgtgatccat gcggttaccg cccgcgtgtc 11520 gaacccaggt gtgcgacgtc agacaacggg ggagtgctcc ttttggcttc cttccaggcg 11580 cggcggctgc tgcgctagct tttttggcca ctggccgcgc gcagcgtaag cggttaggct 11640 ggaaagcgaa agcattaagt ggctcgctcc ctgtagccgg agggttattt tccaagggtt 11700 gagtcgcggg acccccggtt cgagtctcgg accggccgga ctgcggcgaa cgggggtttg 11760 cctccccgtc atgcaagacc ccgcttgcaa attcctccgg aaacagggac gagccccttt 11820 tttgcttttc ccagatgcat ccggtgctgc ggcagatgcg cccccctcct cagcagcggc 11880 aagagcaaga gcagcggcag acatgcaggg caccctcccc tcctcctacc gcgtcaggag 11940 gggcgacatc cgcggttgac gcggcagcag atggtgatta cgaacccccg cggcgccggg 12000 cccggcacta cctggacttg gaggagggcg agggcctggc gcggctagga gcgccctctc 12060 ctgagcggca cccaagggtg cagctgaagc gtgatacgcg tgaggcgtac gtgccgcggc 12120 agaacctgtt tcgcgaccgc gagggagagg agcccgagga gatgcgggat cgaaagttcc 12180 acgcagggcg cgagctgcgg catggcctga atcgcgagcg gttgctgcgc gaggaggact 12240 ttgagcccga cgcgcgaacc gggattagtc ccgcgcgcgc acacgtggcg gccgccgacc 12300 tggtaaccgc atacgagcag acggtgaacc aggagattaa ctttcaaaaa agctttaaca 12360 accacgtgcg tacgcttgtg gcgcgcgagg aggtggctat aggactgatg catctgtggg 12420 actttgtaag cgcgctggag caaaacccaa atagcaagcc gctcatggcg cagctgttcc 12480 ttatagtgca gcacagcagg gacaacgagg cattcaggga tgcgctgcta aacatagtag 12540 agcccgaggg ccgctggctg ctcgatttga taaacatcct gcagagcata gtggtgcagg 12600 agcgcagctt gagcctggct gacaaggtgg ccgccatcaa ctattccatg cttagcctgg 12660 gcaagtttta cgcccgcaag atataccata ccccttacgt tcccatagac aaggaggtaa 12720 agatcgaggg gttctacatg cgcatggcgc tgaaggtgct taccttgagc gacgacctgg 12780 gcgtttatcg caacgagcgc atccacaagg ccgtgagcgt gagccggcgg cgcgagctca 12840 gcgaccgcga gctgatgcac agcctgcaaa gggccctggc tggcacgggc agcggcgata 12900 gagaggccga gtcctacttt gacgcgggcg ctgacctgcg ctgggcccca agccgacgcg 12960 ccctggaggc agctggggcc ggacctgggc tggcggtggc acccgcgcgc gctggcaacg 13020 tcggcggcgt ggaggaatat gacgaggacg atgagtacga gccagaggac ggcgagtact 13080 aagcggtgat gtttctgatc agatgatgca agacgcaacg gacccggcgg tgcgggcggc 13140 gctgcagagc cagccgtccg gccttaactc cacggacgac tggcgccagg tcatggaccg 13200 catcatgtcg ctgactgcgc gcaatcctga cgcgttccgg cagcagccgc aggccaaccg 13260 gctctccgca attctggaag cggtggtccc ggcgcgcgca aaccccacgc acgagaaggt 13320 gctggcgatc gtaaacgcgc tggccgaaaa cagggccatc cggcccgacg aggccggcct 13380 ggtctacgac gcgctgcttc agcgcgtggc tcgttacaac agcggcaacg tgcagaccaa 13440 cctggaccgg ctggtggggg atgtgcgcga ggccgtggcg cagcgtgagc gcgcgcagca 13500 gcagggcaac ctgggctcca tggttgcact aaacgccttc ctgagtacac agcccgccaa 13560 cgtgccgcgg ggacaggagg actacaccaa ctttgtgagc gcactgcggc taatggtgac 13620 tgagacaccg caaagtgagg tgtaccagtc tgggccagac tattttttcc agaccagtag 13680 acaaggcctg cagaccgtaa acctgagcca ggctttcaaa aacttgcagg ggctgtgggg 13740 ggtgcgggct cccacaggcg accgcgcgac cgtgtctagc ttgctgacgc ccaactcgcg 13800 cctgttgctg ctgctaatag cgcccttcac ggacagtggc agcgtgtccc gggacacata 13860 cctaggtcac ttgctgacac tgtaccgcga ggccataggt caggcgcatg tggacgagca 13920 tactttccag gagattacaa gtgtcagccg cgcgctgggg caggaggaca cgggcagcct 13980 ggaggcaacc ctaaactacc tgctgaccaa ccggcggcag aagatcccct cgttgcacag 14040 tttaaacagc gaggaggagc gcattttgcg ctacgtgcag cagagcgtga gccttaacct 14100 gatgcgcgac ggggtaacgc ccagcgtggc gctggacatg accgcgcgca acatggaacc 14160 gggcatgtat gcctcaaacc ggccgtttat caaccgccta atggactact tgcatcgcgc 14220 ggccgccgtg aaccccgagt atttcaccaa tgccatcttg aacccgcact ggctaccgcc 14280 ccctggtttc tacaccgggg gattcgaggt gcccgagggt aacgatggat tcctctggga 14340 cgacatagac gacagcgtgt tttccccgca accgcagacc ctgctagagt tgcaacagcg 14400 cgagcaggca gaggcggcgc tgcgaaagga aagcttccgc aggccaagca gcttgtccga 14460 tctaggcgct gcggccccgc ggtcagatgc tagtagccca tttccaagct tgatagggtc 14520 tcttaccagc actcgcacca cccgcccgcg cctgctgggc gaggaggagt acctaaacaa 14580 ctcgctgctg cagccgcagc gcgaaaaaaa cctgcctccg gcatttccca acaacgggat 14640 agagagccta gtggacaaga tgagtagatg gaagacgtac gcgcaggagc acagggacgt 14700 gccaggcccg cgcccgccca cccgtcgtca aaggcacgac cgtcagcggg gtctggtgtg 14760 ggaggacgat gactcggcag acgacagcag cgtcctggat ttgggaggga gtggcaaccc 14820 gtttgcgcac cttcgcccca ggctggggag aatgttttaa aaaaaaaaaa aaagcatgat 14880 gcaaaataaa aaactcacca aggccatggc accgagcgtt ggttttcttg tattcccctt 14940 agtatgcggc gcgcggcgat gtatgaggaa ggtcctcctc cctcctacga gagtgtggtg 15000 agcgcggcgc cagtggcggc ggcgctgggt tctcccttcg atgctcccct ggacccgccg 15060 tttgtgcctc cgcggtacct gcggcctacc ggggggagaa acagcatccg ttactctgag 15120 ttggcacccc tattcgacac cacccgtgtg tacctggtgg acaacaagtc aacggatgtg 15180 gcatccctga actaccagaa cgaccacagc aactttctga ccacggtcat tcaaaacaat 15240 gactacagcc cgggggaggc aagcacacag accatcaatc ttgacgaccg gtcgcactgg 15300 ggcggcgacc tgaaaaccat cctgcatacc aacatgccaa atgtgaacga gttcatgttt 15360 accaataagt ttaaggcgcg ggtgatggtg tcgcgcttgc ctactaagga caatcaggtg 15420 gagctgaaat acgagtgggt ggagttcacg ctgcccgagg gcaactactc cgagaccatg 15480 accatagacc ttatgaacaa cgcgatcgtg gagcactact tgaaagtggg cagacagaac 15540 ggggttctgg aaagcgacat cggggtaaag tttgacaccc gcaacttcag actggggttt 15600 gaccccgtca ctggtcttgt catgcctggg gtatatacaa acgaagcctt ccatccagac 15660 atcattttgc tgccaggatg cggggtggac ttcacccaca gccgcctgag caacttgttg 15720 ggcatccgca agcggcaacc cttccaggag ggctttagga tcacctacga tgatctggag 15780 ggtggtaaca ttcccgcact gttggatgtg gacgcctacc aggcgagctt gaaagatgac 15840 accgaacagg gcgggggtgg cgcaggcggc agcaacagca gtggcagcgg cgcggaagag 15900 aactccaacg cggcagccgc ggcaatgcag ccggtggagg acatgaacga tcatgccatt 15960 cgcggcgaca cctttgccac acgggctgag gagaagcgcg ctgaggccga agcagcggcc 16020 gaagctgccg cccccgctgc gcaacccgag gtcgagaagc ctcagaagaa accggtgatc 16080 aaacccctga cagaggacag caagaaacgc agttacaacc taataagcaa tgacagcacc 16140 ttcacccagt accgcagctg gtaccttgca tacaactacg gcgaccctca gaccggaatc 16200 cgctcatgga ccctgctttg cactcctgac gtaacctgcg gctcggagca ggtctactgg 16260 tcgttgccag acatgatgca agaccccgtg accttccgct ccacgcgcca gatcagcaac 16320 tttccggtgg tgggcgccga gctgttgccc gtgcactcca agagcttcta caacgaccag 16380 gccgtctact cccaactcat ccgccagttt acctctctga cccacgtgtt caatcgcttt 16440 cccgagaacc agattttggc gcgcccgcca gcccccacca tcaccaccgt cagtgaaaac 16500 gttcctgctc tcacagatca cgggacgcta ccgctgcgca acagcatcgg aggagtccag 16560 cgagtgacca ttactgacgc cagacgccgc acctgcccct acgtttacaa ggccctgggc 16620 atagtctcgc cgcgcgtcct atcgagccgc actttttgag caagcatgtc catccttata 16680 tcgcccagca ataacacagg ctggggcctg cgcttcccaa gcaagatgtt tggcggggcc 16740 aagaagcgct ccgaccaaca cccagtgcgc gtgcgcgggc actaccgcgc gccctggggc 16800 gcgcacaaac gcggccgcac tgggcgcacc accgtcgatg acgccatcga cgcggtggtg 16860 gaggaggcgc gcaactacac gcccacgccg ccaccagtgt ccacagtgga cgcggccatt 16920 cagaccgtgg tgcgcggagc ccggcgctat gctaaaatga agagacggcg gaggcgcgta 16980 gcacgtcgcc accgccgccg acccggcact gccgcccaac gcgcggcggc ggccctgctt 17040 aaccgcgcac gtcgcaccgg ccgacgggcg gccatgcggg ccgctcgaag gctggccgcg 17100 ggtattgtca ctgtgccccc caggtccagg cgacgagcgg ccgccgcagc agccgcggcc 17160 attagtgcta tgactcaggg tcgcaggggc aacgtgtatt gggtgcgcga ctcggttagc 17220 ggcctgcgcg tgcccgtgcg cacccgcccc ccgcgcaact agattgcaag aaaaaactac 17280 ttagactcgt actgttgtat gtatccagcg gcggcggcgc gcaacgaagc tatgtccaag 17340 cgcaaaatca aagaagagat gctccaggtc atcgcgccgg agatctatgg ccccccgaag 17400 aaggaagagc aggattacaa gccccgaaag ctaaagcggg tcaaaaagaa aaagaaagat 17460 gatgatgatg aacttgacga cgaggtggaa ctgctgcacg ctaccgcgcc caggcgacgg 17520 gtacagtgga aaggtcgacg cgtaaaacgt gttttgcgac ccggcaccac cgtagtcttt 17580 acgcccggtg agcgctccac ccgcacctac aagcgcgtgt atgatgaggt gtacggcgac 17640 gaggacctgc ttgagcaggc caacgagcgc ctcggggagt ttgcctacgg aaagcggcat 17700 aaggacatgc tggcgttgcc gctggacgag ggcaacccaa cacctagcct aaagcccgta 17760 acactgcagc aggtgctgcc cgcgcttgca ccgtccgaag aaaagcgcgg cctaaagcgc 17820 gagtctggtg acttggcacc caccgtgcag ctgatggtac ccaagcgcca gcgactggaa 17880 gatgtcttgg aaaaaatgac cgtggaacct gggctggagc ccgaggtccg cgtgcggcca 17940 atcaagcagg tggcgccggg actgggcgtg cagaccgtgg acgttcagat acccactacc 18000 agtagcacca gtattgccac cgccacagag ggcatggaga cacaaacgtc cccggttgcc 18060 tcagcggtgg cggatgccgc ggtgcaggcg gtcgctgcgg ccgcgtccaa gacctctacg 18120 gaggtgcaaa cggacccgtg gatgtttcgc gtttcagccc cccggcgccc gcgccgttcg 18180 aggaagtacg gcgccgccag cgcgctactg cccgaatatg ccctacatcc ttccattgcg 18240 cctacccccg gctatcgtgg ctacacctac cgccccagaa gacgagcaac tacccgacgc 18300 cgaaccacca ctggaacccg ccgccgccgt cgccgtcgcc agcccgtgct ggccccgatt 18360 tccgtgcgca gggtggctcg cgaaggaggc aggaccctgg tgctgccaac agcgcgctac 18420 caccccagca tcgtttaaaa gccggtcttt gtggttcttg cagatatggc cctcacctgc 18480 cgcctccgtt tcccggtgcc gggattccga ggaagaatgc accgtaggag gggcatggcc 18540 ggccacggcc tgacgggcgg catgcgtcgt gcgcaccacc ggcggcggcg cgcgtcgcac 18600 cgtcgcatgc gcggcggtat cctgcccctc cttattccac tgatcgccgc ggcgattggc 18660 gccgtgcccg gaattgcatc cgtggccttg caggcgcaga gacactgatt aaaaacaagt 18720 tgcatgtgga aaaatcaaaa taaaaagtct ggactctcac gctcgcttgg tcctgtaact 18780 attttgtaga atggaagaca tcaactttgc gtctctggcc ccgcgacacg gctcgcgccc 18840 gttcatggga aactggcaag atatcggcac cagcaatatg agcggtggcg ccttcagctg 18900 gggctcgctg tggagcggca ttaaaaattt cggttccacc gttaagaact atggcagcaa 18960 ggcctggaac agcagcacag gccagatgct gagggataag ttgaaagagc aaaatttcca 19020 acaaaaggtg gtagatggcc tggcctctgg cattagcggg gtggtggacc tggccaacca 19080 ggcagtgcaa aataagatta acagtaagct tgatccccgc cctcccgtag aggagcctcc 19140 accggccgtg gagacagtgt ctccagaggg gcgtggcgaa aagcgtccgc gccccgacag 19200 ggaagaaact ctggtgacgc aaatagacga gcctccctcg tacgaggagg cactaaagca 19260 aggcctgccc accacccgtc ccatcgcgcc catggctacc ggagtgctgg gccagcacac 19320 acccgtaacg ctggacctgc ctccccccgc cgacacccag cagaaacctg tgctgccagg 19380 cccgaccgcc gttgttgtaa cccgtcctag ccgcgcgtcc ctgcgccgcg ccgccagcgg 19440 tccgcgatcg ttgcggcccg tagccagtgg caactggcaa agcacactga acagcatcgt 19500 gggtctgggg gtgcaatccc tgaagcgccg acgatgcttc tgatagctaa cgtgtcgtat 19560 gtgtgtcatg tatgcgtcca tgtcgccgcc agaggagctg ctgagccgcc gcgcgcccgc 19620 tttccaagat ggctacccct tcgatgatgc cgcagtggtc ttacatgcac atctcgggcc 19680 aggacgcctc ggagtacctg agccccgggc tggtgcagtt tgcccgcgcc accgagacgt 19740 acttcagcct gaataacaag tttagaaacc ccacggtggc gcctacgcac gacgtgacca 19800 cagaccggtc ccagcgtttg acgctgcggt tcatccctgt ggaccgtgag gatactgcgt 19860 actcgtacaa ggcgcggttc accctagctg tgggtgataa ccgtgtgctg gacatggctt 19920 ccacgtactt tgacatccgc ggcgtgctgg acaggggccc tacttttaag ccctactctg 19980 gcactgccta caacgccctg gctcccaagg gtgccccaaa tccttgcgaa tgggatgaag 20040 ctgctactgc tcttgaaata aacctagaag aagaggacga tgacaacgaa gacgaagtag 20100 acgagcaagc tgagcagcaa aaaactcacg tatttgggca ggcgccttat tctggtataa 20160 atattacaaa ggagggtatt caaataggtg tcgaaggtca aacacctaaa tatgccgata 20220 aaacatttca acctgaacct caaataggag aatctcagtg gtacgaaaca gaaattaatc 20280 atgcagctgg gagagtccta aaaaagacta ccccaatgaa accatgttac ggttcatatg 20340 caaaacccac aaatgaaaat ggagggcaag gcattcttgt aaagcaacaa aatggaaagc 20400 tagaaagtca agtggaaatg caatttttct caactactga ggcagccgca ggcaatggtg 20460 ataacttgac tcctaaagtg gtattgtaca gtgaagatgt agatatagaa accccagaca 20520 ctcatatttc ttacatgccc actattaagg aaggtaactc acgagaacta atgggccaac 20580 aatctatgcc caacaggcct aattacattg cttttaggga caattttatt ggtctaatgt 20640 attacaacag cacgggtaat atgggtgttc tggcgggcca agcatcgcag ttgaatgctg 20700 ttgtagattt gcaagacaga aacacagagc tttcatacca gcttttgctt gattccattg 20760 gtgatagaac caggtacttt tctatgtgga atcaggctgt tgacagctat gatccagatg 20820 ttagaattat tgaaaatcat ggaactgaag atgaacttcc aaattactgc tttccactgg 20880 gaggtgtgat taatacagag actcttacca aggtaaaacc taaaacaggt caggaaaatg 20940 gatgggaaaa agatgctaca gaattttcag ataaaaatga aataagagtt ggaaataatt 21000 ttgccatgga aatcaatcta aatgccaacc tgtggagaaa tttcctgtac tccaacatag 21060 cgctgtattt gcccgacaag ctaaagtaca gtccttccaa cgtaaaaatt tctgataacc 21120 caaacaccta cgactacatg aacaagcgag tggtggctcc cgggctagtg gactgctaca 21180 ttaaccttgg agcacgctgg tcccttgact atatggacaa cgtcaaccca tttaaccacc 21240 accgcaatgc tggcctgcgc taccgctcaa tgttgctggg caatggtcgc tatgtgccct 21300 tccacatcca ggtgcctcag aagttctttg ccattaaaaa cctccttctc ctgccgggct 21360 catacaccta cgagtggaac ttcaggaagg atgttaacat ggttctgcag agctccctag 21420 gaaatgacct aagggttgac ggagccagca ttaagtttga tagcatttgc ctttacgcca 21480 ccttcttccc catggcccac aacaccgcct ccacgcttga ggccatgctt agaaacgaca 21540 ccaacgacca gtcctttaac gactatctct ccgccgccaa catgctctac cctatacccg 21600 ccaacgctac caacgtgccc atatccatcc cctcccgcaa ctgggcggct ttccgcggct 21660 gggccttcac gcgccttaag actaaggaaa ccccatcact gggctcgggc tacgaccctt 21720 attacaccta ctctggctct ataccctacc tagatggaac cttttacctc aaccacacct 21780 ttaagaaggt ggccattacc tttgactctt ctgtcagctg gcctggcaat gaccgcctgc 21840 ttacccccaa cgagtttgaa attaagcgct cagttgacgg ggagggttac aacgttgccc 21900 agtgtaacat gaccaaagac tggttcctgg tacaaatgct agctaactat aacattggct 21960 accagggctt ctatatccca gagagctaca aggaccgcat gtactccttc tttagaaact 22020 tccagcccat gagccgtcag gtggtggatg atactaaata caaggactac caacaggtgg 22080 gcatcctaca ccaacacaac aactctggat ttgttggcta ccttgccccc accatgcgcg 22140 aaggacaggc ctaccctgct aacttcccct atccgcttat aggcaagacc gcagttgaca 22200 gcattaccca gaaaaagttt ctttgcgatc gcaccctttg gcgcatccca ttctccagta 22260 actttatgtc catgggcgca ctcacagacc tgggccaaaa ccttctctac gccaactccg 22320 cccacgcgct agacatgact tttgaggtgg atcccatgga cgagcccacc cttctttatg 22380 ttttgtttga agtctttgac gtggtccgtg tgcaccagcc gcaccgcggc gtcatcgaaa 22440 ccgtgtacct gcgcacgccc ttctcggccg gcaacgccac aacataaaga agcaagcaac 22500 atcaacaaca gctgccgcca tgggctccag tgagcaggaa ctgaaagcca ttgtcaaaga 22560 tcttggttgt gggccatatt ttttgggcac ctatgacaag cgctttccag gctttgtttc 22620 tccacacaag ctcgcctgcg ccatagtcaa tacggccggt cgcgagactg ggggcgtaca 22680 ctggatggcc tttgcctgga acccgcactc aaaaacatgc tacctctttg agccctttgg 22740 cttttctgac cagcgactca agcaggttta ccagtttgag tacgagtcac tcctgcgccg 22800 tagcgccatt gcttcttccc ccgaccgctg tataacgctg gaaaagtcca cccaaagcgt 22860 acaggggccc aactcggccg cctgtggact attctgctgc atgtttctcc acgcctttgc 22920 caactggccc caaactccca tggatcacaa ccccaccatg aaccttatta ccggggtacc 22980 caactccatg ctcaacagtc cccaggtaca gcccaccctg cgtcgcaacc aggaacagct 23040 ctacagcttc ctggagcgcc actcgcccta cttccgcagc cacagtgcgc agattaggag 23100 cgccacttct ttttgtcact tgaaaaacat gtaaaaataa tgtactagag acactttcaa 23160 taaaggcaaa tgcttttatt tgtacactct cgggtgatta tttaccccca cccttgccgt 23220 ctgcgccgtt taaaaatcaa aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga 23280 cacgttgcga tactggtgtt tagtgctcca cttaaactca ggcacaacca tccgcggcag 23340 ctcggtgaag ttttcactcc acaggctgcg caccatcacc aacgcgttta gcaggtcggg 23400 cgccgatatc ttgaagtcgc agttggggcc tccgccctgc gcgcgcgagt tgcgatacac 23460 agggttgcag cactggaaca ctatcagcgc cgggtggtgc acgctggcca gcacgctctt 23520 gtcggagatc agatccgcgt ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt 23580 tggtagctgc cttcccaaaa agggcgcgtg cccaggcttt gagttgcact cgcaccgtag 23640 tggcatcaaa aggtgaccgt gcccggtctg ggcgttagga tacagcgcct gcataaaagc 23700 cttgatctgc ttaaaagcca cctgagcctt tgcgccttca gagaagaaca tgccgcaaga 23760 cttgccggaa aactgattgg ccggacaggc cgcgtcgtgc acgcagcacc ttgcgtcggt 23820 gttggagatc tgcaccacat ttcggcccca ccggttcttc acgatcttgg ccttgctaga 23880 ctgctccttc agcgcgcgct gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc 23940 cttatttatc ataatgcttc cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg 24000 gtgcagccac aacgcgcagc ccgtgggctc gtgatgcttg taggtcacct ctgcaaacga 24060 ctgcaggtac gcctgcagga atcgccccat catcgtcaca aaggtcttgt tgctggtgaa 24120 ggtcagctgc aacccgcggt gctcctcgtt cagccaggtc ttgcatacgg ccgccagagc 24180 ttccacttgg tcaggcagta gtttgaagtt cgcctttaga tcgttatcca cgtggtactt 24240 gtccatcagc gcgcgcgcag cctccatgcc cttctcccac gcagacacga tcggcacact 24300 cagcgggttc atcaccgtaa tttcactttc cgcttcgctg ggctcttcct cttcctcttg 24360 cgtccgcata ccacgcgcca ctgggtcgtc ttcattcagc cgccgcactg tgcgcttacc 24420 tcctttgcca tgcttgatta gcaccggtgg gttgctgaaa cccaccattt gtagcgccac 24480 atcttctctt tcttcctcgc tgtccacgat tacctctggt gatggcgggc gctcgggctt 24540 gggagaaggg cgcttctttt tcttcttggg cgcaatggcc aaatccgccg ccgaggtcga 24600 tggccgcggg ctgggtgtgc gcggcaccag cgcgtcttgt gatgagtctt cctcgtcctc 24660 ggactcgata cgccgcctca tccgcttttt tgggggcgcc cggggaggcg gcggcgacgg 24720 ggacggggac gacacgtcct ccatggttgg gggacgtcgc gccgcaccgc gtccgcgctc 24780 gggggtggtt tcgcgctgct cctcttcccg actggccatt tccttctcct ataggcagaa 24840 aaagatcatg gagtcagtcg agaagaagga cagcctaacc gccccctctg agttcgccac 24900 caccgcctcc accgatgccg ccaacgcgcc taccaccttc cccgtcgagg cacccccgct 24960 tgaggaggag gaagtgatta tcgagcagga cccaggtttt gtaagcgaag acgacgagga 25020 ccgctcagta ccaacagagg ataaaaagca agaccaggac aacgcagagg caaacgagga 25080 acaagtcggg cggggggacg aaaggcatgg cgactaccta gatgtgggag acgacgtgct 25140 gttgaagcat ctgcagcgcc agtgcgccat tatctgcgac gcgttgcaag agcgcagcga 25200 tgtgcccctc gccatagcgg atgtcagcct tgcctacgaa cgccacctat tctcaccgcg 25260 cgtacccccc aaacgccaag aaaacggcac atgcgagccc aacccgcgcc tcaacttcta 25320 ccccgtattt gccgtgccag aggtgcttgc cacctatcac atctttttcc aaaactgcaa 25380 gataccccta tcctgccgtg ccaaccgcag ccgagcggac aagcagctgg ccttgcggca 25440 gggcgctgtc atacctgata tcgcctcgct caacgaagtg ccaaaaatct ttgagggtct 25500 tggacgcgac gagaagcgcg cggcaaacgc tctgcaacag gaaaacagcg aaaatgaaag 25560 tcactctgga gtgttggtgg aactcgaggg tgacaacgcg cgcctagccg tactaaaacg 25620 cagcatcgag gtcacccact ttgcctaccc ggcacttaac ctacccccca aggtcatgag 25680 cacagtcatg agtgagctga tcgtgcgccg tgcgcagccc ctggagaggg atgcaaattt 25740 gcaagaacaa acagaggagg gcctacccgc agttggcgac gagcagctag cgcgctggct 25800 tcaaacgcgc gagcctgccg acttggagga gcgacgcaaa ctaatgatgg ccgcagtgct 25860 cgttaccgtg gagcttgagt gcatgcagcg gttctttgct gacccggaga tgcagcgcaa 25920 gctagaggaa acattgcact acacctttcg acagggctac gtacgccagg cctgcaagat 25980 ctccaacgtg gagctctgca acctggtctc ctaccttgga attttgcacg aaaaccgcct 26040 tgggcaaaac gtgcttcatt ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga 26100 ctgcgtttac ttatttctat gctacacctg gcagacggcc atgggcgttt ggcagcagtg 26160 cttggaggag tgcaacctca aggagctgca gaaactgcta aagcaaaact tgaaggacct 26220 atggacggcc ttcaacgagc gctccgtggc cgcgcacctg gcggacatca ttttccccga 26280 acgcctgctt aaaaccctgc aacagggtct gccagacttc accagtcaaa gcatgttgca 26340 gaactttagg aactttatcc tagagcgctc aggaatcttg cccgccacct gctgtgcact 26400 tcctagcgac tttgtgccca ttaagtaccg cgaatgccct ccgccgcttt ggggccactg 26460 ctaccttctg cagctagcca actaccttgc ctaccactct gacataatgg aagacgtgag 26520 cggtgacggt ctactggagt gtcactgtcg ctgcaaccta tgcaccccgc accgctccct 26580 ggtttgcaat tcgcagctgc ttaacgaaag tcaaattatc ggtacctttg agctgcaggg 26640 tccctcgcct gacgaaaagt ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac 26700 gtcggcttac cttcgcaaat ttgtacctga ggactaccac gcccacgaga ttaggttcta 26760 cgaagaccaa tcccgcccgc ctaatgcgga gcttaccgcc tgcgtcatta cccagggcca 26820 cattcttggc caattgcaag ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg 26880 acggggggtt tacttggacc cccagtccgg cgaggagctc aacccaatcc ccccgccgcc 26940 gcagccctat cagcagcagc cgcgggccct tgcttcccag gatggcaccc aaaaagaagc 27000 tgcagctgcc gccgccaccc acggacgagg aggaatactg ggacagtcag gcagaggagg 27060 ttttggacga ggaggaggag gacatgatgg aagactggga gagcctagac gaggaagctt 27120 ccgaggtcga agaggtgtca gacgaaacac cgtcaccctc ggtcgcattc ccctcgccgg 27180 cgccccagaa atcggcaacc ggttccagca tggctacaac ctccgctcct caggcgccgc 27240 cggcactgcc cgttcgccga cccaaccgta gatgggacac cactggaacc agggccggta 27300 agtccaagca gccgccgccg ttagcccaag agcaacaaca gcgccaaggc taccgctcat 27360 ggcgcgggca caagaacgcc atagttgctt gcttgcaaga ctgtgggggc aacatctcct 27420 tcgcccgccg ctttcttctc taccatcacg gcgtggcctt cccccgtaac atcctgcatt 27480 actaccgtca tctctacagc ccatactgca ccggcggcag cggcagcaac agcagcggcc 27540 acacagaagc aaaggcgacc ggatagcaag actctgacaa agcccaagaa atccacagcg 27600 gcggcagcag caggaggagg agcgctgcgt ctggcgccca acgaacccgt atcgacccgc 27660 gagcttagaa acaggatttt tcccactctg tatgctatat ttcaacagag caggggccaa 27720 gaacaagagc tgaaaataaa aaacaggtct ctgcgatccc tcacccgcag ctgcctgtat 27780 cacaaaagcg aagatcagct tcggcgcacg ctggaagacg cggaggctct cttcagtaaa 27840 tactgcgcgc tgactcttaa ggactagttt cgcgcccttt ctcaaattta agcgcgaaaa 27900 ctacgtcatc tccagcggcc acacccggcg ccagcacctg tcgtcagcgc catttatgag 27960 caaggaaatt cccacgccct acatgtggag ttaccagcca caaatgggac ttgcggctgg 28020 agctgcccaa gactactcaa cccgaataaa ctacatgagc gcgggacccc acatgatatc 28080 ccgggtcaac ggaatacgcg cccaccgaaa ccgaattctc ctggaacagg cggctattac 28140 caccacacct cgtaataacc ttaatccccg tagttggccc gctgccctgg tgtaccagga 28200 aagtcccgct cccaccactg tggtacttcc cagagacgcc caggccgaag ttcagatgac 28260 taactcaggg gcgcagcttg cgggcggctt tcgtcacagg gtgcggtcgc ccgggcaggg 28320 tataactcac ctgacaatca gagggcgagg tattcagctc aacgacgagt cggtgagctc 28380 ctcgcttggt ctccgtccgg acgggacatt tcagatcggc ggcgccggcc gctcttcatt 28440 cacgcctcgt caggcaatcc taactctgca gacctcgtcc tctgagccgc gctctggagg 28500 cattggaact ctgcaattta ttgaggagtt tgtgccatcg gtctacttta accccttctc 28560 gggacctccc ggccactatc cggatcaatt tattcctaac tttgacgcgg taaaggactc 28620 ggcggacggc tacgactgaa tgttaagtgg agaggcagag caactgcgcc tgaaacacct 28680 ggtccactgt cgccgccaca agtgctttgc ccgcgactcc ggtgagtttt gctactttga 28740 attgcccgag gatcatatcg agggcccggc gcacggcgtc cggcttaccg cccagggaga 28800 gcttgcccgt agcctgattc gggagtttac ccagcgcccc ctgctagttg agcgggacag 28860 gggaccctgt gttctcactg tgatttgcaa ctgtcctaac cctggattac atcaagatct 28920 ttgttgccat ctctgtgctg agtataataa atacagaaat taaaatatac tggggctcct 28980 atcgccatcc tgtaaacgcc accgtcttca cccgcccaag caaaccaagg cgaaccttac 29040 ctggtacttt taacatctct ccctctgtga tttacaacag tttcaaccca gacggagtga 29100 gtctacgaga gaacctctcc gagctcagct actccatcag aaaaaacacc accctcctta 29160 cctgccggga acgtacgagt gcgtcaccgg ccgctgcacc acacctaccg cctgaccgta 29220 aaccagactt tttccggaca gacctcaata actctgttta ccagaacagg aggtgagctt 29280 agaaaaccct tagggtatta ggccaaaggc gcagctactg tggggtttat gaacaattca 29340 agcaactcta cgggctattc taattcaggt ttctctagaa tcggggttgg ggttattctc 29400 tgtcttgtga ttctctttat tcttatacta acgcttctct gcctaaggct cgccgcctgc 29460 tgtgtgcaca tttgcattta ttgtcagctt tttaaacgct ggggtcgcca cccaagatga 29520 ttaggtacat aatcctaggt ttactcaccc ttgcgtcagc ccacggtacc acccaaaagg 29580 tggattttaa ggagccagcc tgtaatgtta cattcgcagc tgaagctaat gagtgcacca 29640 ctcttataaa atgcaccaca gaacatgaaa agctgcttat tcgccacaaa aacaaaattg 29700 gcaagtatgc tgtttatgct atttggcagc caggtgacac tacagagtat aatgttacag 29760 ttttccaggg taaaagtcat aaaactttta tgtatacttt tccattttat gaaatgtgcg 29820 acattaccat gtacatgagc aaacagtata agttgtggcc cccacaaaat tgtgtggaaa 29880 acactggcac tttctgctgc actgctatgc taattacagt gctcgctttg gtctgtaccc 29940 tactctatat taaatacaaa agcagacgca gctttattga ggaaaagaaa atgccttaat 30000 ttactaagtt acaaagctaa tgtcaccact aactgcttta ctcgctgctt gcaaaacaaa 30060 ttcaaaaagt tagcattata attagaatag gatttaaacc ccccggtcat ttcctgctca 30120 ataccattcc cctgaacaat tgactctatg tgggatatgc tccagcgcta caaccttgaa 30180 gtcaggcttc ctggatgtca gcatctgact ttggccagca cctgtcccgc ggatttgttc 30240 cagtccaact acagcgaccc accctaacag agatggccgt tcagctggtg gaaagtggcg 30300 ggggttctgt tcaggcgggc gggtctctga ggcttacttg cgccgcgagt ggtagaacca 30360 gtcggagcta cggaatgggg tggtttaggc aagctcccgg gaaagaacgc gaatttgtga 30420 gcggcattag ctggcggggc gattccactg ggtacgcaga ctctgtaaag ggaaggttta 30480 ccatcagccg cgataacgca aagaacaccg ttgatctgca gatgaatagc ttgagaccgg 30540 aggacaccgc catctactac tgtgcagctg ccgccggaag cacatggtat gggactctgt 30600 atgaatacga ctactggggc cagggtacac aagttaccgt aagcagcggc tctgggtccg 30660 gctcgaccgg agtgcaggtg gaaaccatct ccccaggaga cgggcgcacc ttccccaagc 30720 gcggccagac ctgcgtggtg cactacaccg ggatgcttga agatggaaag aaatttgatt 30780 cctcccggga cagaaacaag ccctttaagt ttatgctagg caagcaggag gtgatccgag 30840 gctgggaaga aggggttgcc cagatgagtg tgggtcagag agccaaactg actatatctc 30900 cagattatgc ctatggtgcc actgggcacc caggcatcat cccaccacat gccactctcg 30960 tcttcgatgt ggagcttcta aaactgggaa gcggagctac taacttcagc ctgctgaagc 31020 aggctggtga cgtcgaggag aatcctggcc caatgaccaa cacaaccaac gcggccgccg 31080 ctaccggact tacatctacc acaaatacac cccaagtttc tgcctttgtc aataactggg 31140 ataacttggg catgtggtgg ttctccatag cgcttatgtt tgtatgcctt attattatgt 31200 ggctcatctg ctgcctaaag cgcaaacgcg cccgaccacc catctatagt cccatcattg 31260 tgctacaccc aaacaatgat ggaatccata gattggacgg actgaaacac atgttctttt 31320 ctcttacagt atgattaaat gagactaata aaaaaaaata ataaagcatc acttacttaa 31380 aatcagttag caaatttctg tccagtttat tcagcagcac ctccttgccc tcctcccagc 31440 tctggtattg cagcttcctc ctggctgcaa actttctcca caatctaaat ggaatgtcag 31500 tttcctcctg ttcctgtcca tccgcaccca ctatcttcat gttgttgcag atgaagcgcg 31560 caagaccgtc tgaagatacc ttcaaccccg tgtatccata tgacacggaa accggtcctc 31620 caactgtgcc ttttcttact cctccctttg tatcccccaa tgggtttcaa gagagtcccc 31680 ctggggtact ctctttgcgc ctatccgaac ctctagttac ctccaatggc atgcttgcgc 31740 tcaaaatggg caacggcctc tctctggacg aggccggcaa ccttacctcc caaaatgtaa 31800 ccactgtgag cccacctctc aaaaaaacca agtcaaacat aaacctggaa atatctgcac 31860 ccctcacagt tacctcagaa gccctaactg tggctgccgc cgcacctcta atggtcgcgg 31920 gcaacacact caccatgcaa tcacaggccc cgctaaccgt gcacgactcc aaacttagca 31980 ttgccaccca aggacccctc acagtgtcag aaggaaagct agccctgcaa acatcaggcc 32040 ccctcaccac caccgatagc agtaccctta ctatcactgc ctcaccccct ctaactactg 32100 ccactggtag cttgggcatt gacttgaaag agcccattta tacacaaaat ggaaaactag 32160 gactaaagta cggggctcct ttgcatgtaa cagacgacct aaacactttg accgtagcaa 32220 ctggtccagg tgtgactatt aataatactt ccttgcaaac taaagttact ggagccttgg 32280 gttttgattc acaaggcaat atgcaactta atgtagcagg aggactaagg attgattctc 32340 aaaacagacg ccttatactt gatgttagtt atccgtttga tgctcaaaac caactaaatc 32400 taagactagg acagggccct ctttttataa actcagccca caacttggat attaactaca 32460 acaaaggcct ttacttgttt acagcttcaa acaattccaa aaagcttgag gttaacctaa 32520 gcactgccaa ggggttgatg tttgacgcta cagccatagc cattaatgca ggagatgggc 32580 ttgaatttgg ttcacctaat gcaccaaaca caaatcccct caaaacaaaa attggccatg 32640 gcctagaatt tgattcaaac aaggctatgg ttcctaaact aggaactggc cttagttttg 32700 acagcacagg tgccattaca gtaggaaaca aaaataatga taagctaact ttgtggacca 32760 caccagctcc atctcctaac tgtagactaa atgcagagaa agatgctaaa ctcactttgg 32820 tcttaacaaa atgtggcagt caaatacttg ctacagtttc agttttggct gttaaaggca 32880 gtttggctcc aatatctgga acagttcaaa gtgctcatct tattataaga tttgacgaaa 32940 atggagtgct actaaacaat tccttcctgg acccagaata ttggaacttt agaaatggag 33000 atcttactga aggcacagcc tatacaaacg ctgttggatt tatgcctaac ctatcagctt 33060 atccaaaatc tcacggtaaa actgccaaaa gtaacattgt cagtcaagtt tacttaaacg 33120 gagacaaaac taaacctgta acactaacca ttacactaaa cggtacacag gaaacaggag 33180 acacaactga gatgtggcat gaaggcctag aagaggcctc tcgcttgtac tttggggaga 33240 ggaacgtcaa aggcatgttt gaggtgctgg agcccctgca tgctatgatg gaacgcggtc 33300 cccagaccct gaaggaaacg tcctttaatc aggcatatgg tcgagattta atggaggcac 33360 aagaatggtg ccgaaagtac atgaaatcag ggaacgtcaa ggacctcacc caagcctggg 33420 acctctacta tcacgtgttc agacgaatct caaagcagcc aagtgcatac tctatgtcat 33480 tttcatggga ctggtctggc cacaactaca ttaatgaaat atttgccaca tcctcttaca 33540 ctttttcata cattgcccaa gaataaagaa tcgtttgtgt tatgtttcaa cgtgtttatt 33600 tttcaattgc agaaaatttc gaatcatttt tcattcagta gtatagcccc accaccacat 33660 agcttataca gatcaccgta cctaaatcaa actcacagaa ccctagtatt caacctgcca 33720 cctccctccc aacacacaga gtacacagtc ctttctcccc ggctggcctt aaaaagcatc 33780 atatcatggg taacagacat attcttaggt gttatattcc acacggtttc ctgtcgagcc 33840 aaacgctcat cagtgatatt aataaactcc ccgggcagct cacttaagtt catgtcgctg 33900 tccagctgct gagccacagg ctgctgtcca acttgcggtt gcttaacggg cggcgaagga 33960 gaagtccacg cctacatggg ggtagagtca taatcgtgca tcaggatagg gcggtggtgc 34020 tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga atacaacatg 34080 gcagtggtct cctcagcgat gattcgcacc gcccgcagca taaggcgcct tgtcctccgg 34140 gcacagcagc gcaccctgat ctcacttaaa tcagcacagt aactgcagca cagcaccaca 34200 atattgttca aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc ggggaccaca 34260 gaacccacgt ggccatcata ccacaagcgc aggtagatta agtggcgacc cctcataaac 34320 acgctggaca taaacattac ctcttttggc atgttgtaat tcaccacctc ccggtaccat 34380 ataaacctct gattaaacat ggcgccatcc accaccatcc taaaccagct ggccaaaacc 34440 tgcccgccgg ctatacactg cagggaaccg ggactggaac aatgacagtg gagagcccag 34500 gactcgtaac catggatcat catgctcgtc atgatatcaa tgttggcaca acacaggcac 34560 acgtgcatac acttcctcag gattacaagc tcctcccgcg ttagaaccat atcccaggga 34620 acaacccatt cctgaatcag cgtaaatccc acactgcagg gaagacctcg cacgtaactc 34680 acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc cagtatggta 34740 gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac tgtacggagt gcgccgagac 34800 aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt agtcatattt 34860 cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg cgtctccggt ctcgccgctt 34920 agatcgctct gtgtagtagt tgtagtatat ccactctctc aaagcatcca ggcgccccct 34980 ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc ctgataacat ccaccaccgc 35040 agaataagcc acacccagcc aacctacaca ttcgttctgc gagtcacaca cgggaggagc 35100 gggaagagct ggaagaacca tgtttttttt tttattccaa aagattatcc aaaacctcaa 35160 aatgaagatc tattaagtga acgcgctccc ctccggtggc gtggtcaaac tctacagcca 35220 aagaacagat aatggcattt gtaagatgtt gcacaatggc ttccaaaagg caaacggccc 35280 tcacgtccaa gtggacgtaa aggctaaacc cttcagggtg aatctcctct ataaacattc 35340 cagcaccttc aaccatgccc aaataattct catctcgcca ccttctcaat atatctctaa 35400 gcaaatcccg aatattaagt ccggccattg taaaaatctg ctccagagcg ccctccacct 35460 tcagcctcaa gcagcgaatc atgattgcaa aaattcaggt tcctcacaga cctgtataag 35520 attcaaaagc ggaacattaa caaaaatacc gcgatcccgt aggtcccttc gcagggccag 35580 ctgaacataa tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc caggaaccat 35640 gacaaaagaa cccacactga ttatgacacg catactcgga gctatgctaa ccagcgtagc 35700 cccgatgtaa gcttgttgca tgggcggcga tataaaatgc aaggtgctgc tcaaaaaatc 35760 aggcaaagcc tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca gataaaggca 35820 ggtaagctcc ggaaccacca cagaaaaaga caccattttt ctctcaaaca tgtctgcggg 35880 tttctgcata aacacaaaat aaaataacaa aaaaacattt aaacattaga agcctgtctt 35940 acaacaggaa aaacaaccct tataagcata agacggacta cggccatgcc ggcgtgaccg 36000 taaaaaaact ggtcaccgtg attaaaaagc accaccgaca gctcctcggt catgtccgga 36060 gtcataatgt aagactcggt aaacacatca ggttgattca catcggtcag tgctaaaaag 36120 cgaccgaaat agcccggggg aatacatacc cgcaggcgta gagacaacat tacagccccc 36180 ataggaggta taacaaaatt aataggagag aaaaacacat aaacacctga aaaaccctcc 36240 tgcctaggca aaatagcacc ctcccgctcc agaacaacat acagcgcttc cacagcggca 36300 gccataacag tcagccttac cagtaaaaaa gaaaacctat taaaaaaaca ccactcgaca 36360 cggcaccagc tcaatcagtc acagtgtaaa aaagggccaa gtgcagagcg agtatatata 36420 ggactaaaaa atgacgtaac ggttaaagtc cacaaaaaac acccagaaaa ccgcacgcga 36480 acctacgccc agaaacgaaa gccaaaaaac ccacaacttc ctcaaatcgt cacttccgtt 36540 ttcccacgtt acgtcacttc ccattttaag aaaactacaa ttcccaacac atacaagtta 36600 ctccgcccta aaacctacgt cacccgcccc gttcccacgc cccgcgccac gtcacaaact 36660 ccaccccctc attatcatat tggcttcaat ccaaaataag gtatattatt gatgatg 36717 <210> 69 <211> 36934 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO172) <400> 69 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattaaac cgtattaccg ccatgcattt aatggagtgc 480 ctcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa 540 gttgggggga ggggtcggca attgaaccgg tgcctagaga aggtggcgcg gggtaaactg 600 ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat 660 aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacaggt 720 aagtgccgtg tgtggttccc gcgggcctgg cctctttacg ggttatggcc cttgcgtgcc 780 ttgaattact tccacctggc tgcagtacgt gattcttgat cccgagcttc gggttggaag 840 tgggtgggag agttcgaggc cttgcgctta aggagcccct tcgcctcgtg cttgagttga 900 ggcctggcct gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct 960 cgctgctttc gataagtctc tagccattta aaatttttga tgacctgctg cgacgctttt 1020 tttctggcaa gatagtcttg taaatgcggg ccaagatctg cacactggta tttcggtttt 1080 tggggccgcg ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg 1140 cctgcgagcg cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct 1200 ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc 1260 ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag ggagctcaaa 1320 atggaggacg cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc 1380 ctttccgtcc tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca 1440 cctcgattag ttctcgagct tttggagtac gtcgtcttta ggttgggggg aggggtttta 1500 tgcgatggag tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt 1560 gatgtaattc tccttggaat ttgccctttt tgagtttgga tcttggttca ttctcaagcc 1620 tcagacagtg gttcaaagtt tttttcttcc atttcaggtg tcgtgacgct agcgctaccg 1680 gactcagatc tcgagctcaa gcttcgaatt ctgcagtcga cggtaccgga tccatggaag 1740 acgccaaaaa cataaagaaa ggcccggcgc cattctatcc gctggaagat ggaaccgctg 1800 gagagcaact gcataaggct atgaagagat acgccctggt tcctggaaca attgctttta 1860 cagatgcaca tatcgaggtg gacatcactt acgctgagta cttcgaaatg tccgttcggt 1920 tggcagaagc tatgaaacga tatgggctga atacaaatca cagaatcgtc gtatgcagtg 1980 aaaactctct tcaattcttt atgccggtgt tgggcgcgtt atttatcgga gttgcagttg 2040 cgcccgcgaa cgacatttat aatgaacgtg aattgctcaa cagtatgggc atttcgcagc 2100 ctaccgtggt gttcgtttcc aaaaaggggt tgcaaaaaat tttgaacgtg caaaaaaagc 2160 tcccaatcat ccaaaaaatt attatcatgg attctaaaac ggattaccag ggatttcagt 2220 cgatgtacac gttcgtcaca tctcatctac ctcccggttt taatgaatac gattttgtgc 2280 cagagtcctt cgatagggac aagacaattg cactgatcat gaactcctct ggatctactg 2340 gtctgcctaa aggtgtcgct ctgcctcata gaactgcctg cgtgagattc tcgcatgcca 2400 gagatcctat ttttggcaat caaatcattc cggatactgc gattttaagt gttgttccat 2460 tccatcacgg ttttggaatg tttactacac tcggatattt gatatgtgga tttcgagtcg 2520 tcttaatgta tagatttgaa gaagagctgt ttctgaggag ccttcaggat tacaagattc 2580 aaagtgcgct gctggtgcca accctattct ccttcttcgc caaaagcact ctgattgaca 2640 aatacgattt atctaattta cacgaaattg cttctggtgg cgctcccctc tctaaggaag 2700 tcggggaagc ggttgccaag aggttccatc tgccaggtat caggcaagga tatgggctca 2760 ctgagactac atcagctatt ctgattacac ccgaggggga tgataaaccg ggcgcggtcg 2820 gtaaagttgt tccatttttt gaagcgaagg ttgtggatct ggataccggg aaaacgctgg 2880 gcgttaatca aagaggcgaa ctgtgtgtga gaggtcctat gattatgtcc ggttatgtaa 2940 acaatccgga agcgaccaac gccttgattg acaaggatgg atggctacat tctggagaca 3000 tagcttactg ggacgaagac gaacacttct tcatcgttga ccgcctgaag tctctgatta 3060 agtacaaagg ctatcaggtg gctcccgctg aattggaatc catcttgctc caacacccca 3120 acatcttcga cgcaggtgtc gcaggtcttc ccgacgatga cgccggtgaa cttcccgccg 3180 ccgttgttgt tttggagcac ggaaagacga tgacggaaaa agagatcgtg gattacgtcg 3240 ccagtcaagt aacaaccgcg aaaaagttgc gcggaggagt tgtgtttgtg gacgaagtac 3300 cgaaaggtct taccggaaaa ctcgacgcaa gaaaaatcag agagatcctc ataaaggcca 3360 agaagggcgg aaagatcgcc gtggcagccg cagccaccat ggtgagcaag ggcgaggagc 3420 tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt 3480 tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca 3540 tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg 3600 gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg 3660 ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca 3720 agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg 3780 gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca 3840 gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga 3900 tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc 3960 ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc 4020 tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg 4080 ccgggatcac tctcggcatg gacgagctgt acaagtaaag cgactctaga tcataatcag 4140 ccatacccaa acaccattgt cacactccaa tcgattcaaa caccattgtc acactccaac 4200 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4260 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4320 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4380 tttgtccaaa ctcatcaatg taagtttaaa cggcgcgcct gaaatgtgtg ggcgtggctt 4440 aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct gttttgcagc 4500 agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct catatttgac 4560 aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca gcattgatgg 4620 tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt ctggaacgcc 4680 gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc gcgggattgt 4740 gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt catccgcccg 4800 cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg aacttaatgt 4860 cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg cttcctcccc 4920 tcccaatgcg gtttaaaaca caacttttct atacaaagtt gtaaataaaa aaccagactc 4980 tgtttggatt tggatcaagc taagtgtctt gctgtcttta tttaggggtt ttgcgcgcgc 5040 ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct gtgtattttt tccaggacgt 5100 ggtaaaggtg actctggatg ttcagataca tgggcataag cccgtctctg gggtggaggt 5160 agcaccactg cagagcttca tgctgcgggg tggtgttgta gatgatccag tcgtagcagg 5220 agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa gctgattgcc aggggcaggc 5280 ccttggtgta agtgtttaca aagcggttaa gctgggatgg gtgcatacgt ggggatatga 5340 gatgcatctt ggactgtatt tttaggttgg ctatgttccc agccatatcc ctccggggat 5400 tcatgttgtg cagaaccacc agcacagtgt atccggtgca cttgggaaat ttgtcatgta 5460 gcttagaagg aaatgcgtgg aagaacttgg agacgccctt gtgacctcca agattttcca 5520 tgcattcgtc cataatgatg gcaatgggcc cacgggcggc ggcctgggcg aagatatttc 5580 tgggatcact aacgtcatag ttgtgttcca ggatgagatc gtcataggcc atttttacaa 5640 agcgcgggcg gagggtgcca gactgcggta taatggttcc atccggccca ggggcgtagt 5700 taccctcaca gatttgcatt tcccacgctt tgagttcaga tggggggatc atgtctacct 5760 gcggggcgat gaagaaaacg gtttccgggg taggggagat cagctgggaa gaaagcaggt 5820 tcctgagcag ctgcgactta ccgcagccgg tgggcccgta aatcacacct attaccggct 5880 gcaactggta gttaagagag ctgcagctgc cgtcatccct gagcaggggg gccacttcgt 5940 taagcatgtc cctgactcgc atgttttccc tgaccaaatc cgccagaagg cgctcgccgc 6000 ccagcgatag cagttcttgc aaggaagcaa agtttttcaa cggtttgaga ccgtccgccg 6060 taggcatgct tttgagcgtt tgaccaagca gttccaggcg gtcccacagc tcggtcacct 6120 gctctacggc atctcgatcc agcatatctc ctcgtttcgc gggttggggc ggctttcgct 6180 gtacggcagt agtcggtgct cgtccagacg ggccagggtc atgtctttcc acgggcgcag 6240 ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc gctccgggct gcgcgctggc 6300 cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc tgccggtctt cgccctgcgc 6360 gtcggccagg tagcatttga ccatggtgtc atagtccagc ccctccgcgg cgtggccctt 6420 ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg cagtgcagac ttttgagggc 6480 gtagagcttg ggcgcgagaa ataccgattc cggggagtag gcatccgcgc cgcaggcccc 6540 gcagacggtc tcgcattcca cgagccaggt gagctctggc cgttcggggt caaaaaccag 6600 gtttccccca tgctttttga tgcgtttctt acctctggtt tccatgagcc ggtgtccacg 6660 ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac ttgagaggcc tgtcctcgag 6720 cggtgttccg cggtcctcct cgtatagaaa ctcggaccac tctgagacaa aggctcgcgt 6780 ccaggccagc acgaaggagg ctaagtggga ggggtagcgg tcgttgtcca ctagggggtc 6840 cactcgctcc agggtgtgaa gacacatgtc gccctcttcg gcatcaagga aggtgattgg 6900 tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg gggctataaa agggggtggg 6960 ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg agggccagct gttggggtga 7020 gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga ttgtcagttt ccaaaaacga 7080 ggaggatttg atattcacct ggcccgcggt gatgcctttg agggtggccg catccatctg 7140 gtcagaaaag acaatctttt tgttgtcaag cttggtggca aacgacccgt agagggcgtt 7200 ggacagcaac ttggcgatgg agcgcagggt ttggtttttg tcgcgatcgg cgcgctcctt 7260 ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac cgccattcgg gaaagacggt 7320 ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg ttgtgcaggg tgacaaggtc 7380 aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc cagcagaggc ggccgccctt 7440 gcgcgagcag aatggcggta gggggtctag ctgcgtctcg tccggggggt ctgcgtccac 7500 ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct atcttgcatc cttgcaagtc 7560 tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg tatgggttga gtgggggacc 7620 ccatggcatg gggtgggtga gcgcggaggc gtacatgccg caaatgtcgt aaacgtagag 7680 gggctctctg agtattccaa gatatgtagg gtagcatctt ccaccgcgga tgctggcgcg 7740 cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg ggaccgaggt tgctacgggc 7800 gggctgctct gctcggaaga ctatctgcct gaagatggca tgtgagttgg atgatatggt 7860 tggacgctgg aagacgttga agctggcgtc tgtgagacct accgcgtcac gcacgaagga 7920 ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg acctgcacgt ctagggcgca 7980 gtagtccagg gtttccttga tgatgtcata cttatcctgt cccttttttt tccacagctc 8040 gcggttgagg acaaactctt cgcggtcttt ccagtactct tggatcggaa acccgtcggc 8100 ctccgaacgg taagagccta gcatgtagaa ctggttgacg gcctggtagg cgcagcatcc 8160 cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg agcgaggtgt gggtgagcgc 8220 aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg aagtcagtgt cgtcgcatcc 8280 gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa cgcggatttg gcagggcgaa 8340 ggtgacatcg ttgaagagta tctttcccgc gcgaggcata aagttgcgtg tgatgcggaa 8400 gggtcccggc acctcggaac ggttgttaat tacctgggcg gcgagcacga tctcgtcaaa 8460 gccgttgatg ttgtggccca caatgtaaag ttccaagaag cgcgggatgc ccttgatgga 8520 aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg gagctgagcc cgtgctctga 8580 aagggcccag tctgcaagat gagggttgga agcgacgaat gagctccaca ggtcacgggc 8640 cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg cgacctatgg ccattttttc 8700 tggggtgatg cagtagaagg taagcgggtc ttgttcccag cggtcccatc caaggttcgc 8760 ggctaggtct cgcgcggcag tcactagagg ctcatctccg ccgaacttca tgaccagcat 8820 gaagggcacg agctgcttcc caaaggcccc catccaagta taggtctcta catcgtaggt 8880 gacaaagaga cgctcggtgc gaggatgcga gccgatcggg aagaactgga tctcccgcca 8940 ccaattggag gagtggctat tgatgtggtg aaagtagaag tccctgcgac gggccgaaca 9000 ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag cggtgcacgg gctgtacatc 9060 ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag agtgggaatt tgagcccctc 9120 gcctggcggg tttggctggt ggtcttctac ttcggctgct tgtccttgac cgtctggctg 9180 ctcgagggga gttacggtgg atcggaccac cacgccgcgc gagcccaaag tccagatgtc 9240 cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga tgggagctgt ccatggtctg 9300 gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg tttacctcgc atagacgggt 9360 cagggcgcgg gctagatcca ggtgatacct aatttccagg ggctggttgg tggcggcgtc 9420 gatggcttgc aagaggccgc atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg 9480 ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt gacgcgggcg agcccccgga 9540 ggtagggggg gctccggacc cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg 9600 ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc 9660 tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag 9720 agttcgacag aatcaatttc ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg 9780 tctcctgagt tgtcttgata ggcgatctcg gccatgaact gctcgatctc ttcctcctgg 9840 agatctccgc gtccggctcg ctccacggtg gcggcgaggt cgttggaaat gcgggccatg 9900 agctgcgaga aggcgttgag gcctccctcg ttccagacgc ggctgtagac cacgccccct 9960 tcggcatcgc gggcgcgcat gaccacctgc gcgagattga gctccacgtg ccgggcgaag 10020 acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc 10080 acgaagaagt acataaccca gcgtcgcaac gtggattcgt tgatatcccc caaggcctca 10140 aggcgctcca tggcctcgta gaagtccacg gcgaagttga aaaactggga gttgcgcgcc 10200 gacacggtta actcctcctc cagaagacgg atgagctcgg cgacagtgtc gcgcacctcg 10260 cgctcaaagg ctacaggggc ctcttcttct tcttcaatct cctcttccat aagggcctcc 10320 ccttcttctt cttctggcgg cggtggggga ggggggacac ggcggcgacg acggcgcacc 10380 gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc gacggcgcat ggtctcggtg 10440 acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc cgcccgtcat gtcccggtta 10500 tgggttggcg gggggctgcc atgcggcagg gatacggcgc taacgatgca tctcaacaat 10560 tgttgtgtag gtactccgcc gccgagggac ctgagcgagt ccgcatcgac cggatcggaa 10620 aacctctcga gaaaggcgtc taaccagtca cagtcgcaag gtaggctgag caccgtggcg 10680 ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg tgctgctgat gatgtaatta 10740 aagtaggcgg tcttgagacg gcggatggtc gacagaagca ccatgtcctt gggtccggcc 10800 tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt tttgacatcg gcgcaggtct 10860 ttgtagtagt cttgcatgag cctttctacc ggcacttctt cttctccttc ctcttgtcct 10920 gcatctcttg catctatcgc tgcggcggcg gcggagtttg gccgtaggtg gcgccctctt 10980 cctcccatgc gtgtgacccc gaagcccctc atcggctgaa gcagggctag gtcggcgaca 11040 acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg tagactggaa gtcatccatg 11100 tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag tgcagttggc cataacggac 11160 cagttaacgg tctggtgacc cggctgcgag agctcggtgt acctgagacg cgagtaagcc 11220 ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt actggtatcc caccaaaaag 11280 tgcggcggcg gctggcggta gaggggccag cgtagggtgg ccggggctcc gggggcgaga 11340 tcttccaaca taaggcgatg atatccgtag atgtacctgg acatccaggt gatgccggcg 11400 gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc agatgttgcg cagcggcaaa 11460 aagtgctcca tggtcgggac gctctggccg gtcaggcgcg cgcaatcgtt gacgctctag 11520 accgtgcaaa aggagagcct gtaagcgggc actcttccgt ggtctggtgg ataaattcgc 11580 aagggtatca tggcggacga ccggggttcg agccccgtat ccggccgtcc gccgtgatcc 11640 atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg tcagacaacg ggggagtgct 11700 ccttttggct tccttccagg cgcggcggct gctgcgctag cttttttggc cactggccgc 11760 gcgcagcgta agcggttagg ctggaaagcg aaagcattaa gtggctcgct ccctgtagcc 11820 ggagggttat tttccaaggg ttgagtcgcg ggacccccgg ttcgagtctc ggaccggccg 11880 gactgcggcg aacgggggtt tgcctccccg tcatgcaaga ccccgcttgc aaattcctcc 11940 ggaaacaggg acgagcccct tttttgcttt tcccagatgc atccggtgct gcggcagatg 12000 cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc agacatgcag ggcaccctcc 12060 cctcctccta ccgcgtcagg aggggcgaca tccgcggttg acgcggcagc agatggtgat 12120 tacgaacccc cgcggcgccg ggcccggcac tacctggact tggaggaggg cgagggcctg 12180 gcgcggctag gagcgccctc tcctgagcgg cacccaaggg tgcagctgaa gcgtgatacg 12240 cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc gcgagggaga ggagcccgag 12300 gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc ggcatggcct gaatcgcgag 12360 cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa ccgggattag tcccgcgcgc 12420 gcacacgtgg cggccgccga cctggtaacc gcatacgagc agacggtgaa ccaggagatt 12480 aactttcaaa aaagctttaa caaccacgtg cgtacgcttg tggcgcgcga ggaggtggct 12540 ataggactga tgcatctgtg ggactttgta agcgcgctgg agcaaaaccc aaatagcaag 12600 ccgctcatgg cgcagctgtt ccttatagtg cagcacagca gggacaacga ggcattcagg 12660 gatgcgctgc taaacatagt agagcccgag ggccgctggc tgctcgattt gataaacatc 12720 ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg ctgacaaggt ggccgccatc 12780 aactattcca tgcttagcct gggcaagttt tacgcccgca agatatacca taccccttac 12840 gttcccatag acaaggaggt aaagatcgag gggttctaca tgcgcatggc gctgaaggtg 12900 cttaccttga gcgacgacct gggcgtttat cgcaacgagc gcatccacaa ggccgtgagc 12960 gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc acagcctgca aagggccctg 13020 gctggcacgg gcagcggcga tagagaggcc gagtcctact ttgacgcggg cgctgacctg 13080 cgctgggccc caagccgacg cgccctggag gcagctgggg ccggacctgg gctggcggtg 13140 gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat atgacgagga cgatgagtac 13200 gagccagagg acggcgagta ctaagcggtg atgtttctga tcagatgatg caagacgcaa 13260 cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc cggccttaac tccacggacg 13320 actggcgcca ggtcatggac cgcatcatgt cgctgactgc gcgcaatcct gacgcgttcc 13380 ggcagcagcc gcaggccaac cggctctccg caattctgga agcggtggtc ccggcgcgcg 13440 caaaccccac gcacgagaag gtgctggcga tcgtaaacgc gctggccgaa aacagggcca 13500 tccggcccga cgaggccggc ctggtctacg acgcgctgct tcagcgcgtg gctcgttaca 13560 acagcggcaa cgtgcagacc aacctggacc ggctggtggg ggatgtgcgc gaggccgtgg 13620 cgcagcgtga gcgcgcgcag cagcagggca acctgggctc catggttgca ctaaacgcct 13680 tcctgagtac acagcccgcc aacgtgccgc ggggacagga ggactacacc aactttgtga 13740 gcgcactgcg gctaatggtg actgagacac cgcaaagtga ggtgtaccag tctgggccag 13800 actatttttt ccagaccagt agacaaggcc tgcagaccgt aaacctgagc caggctttca 13860 aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg cgaccgcgcg accgtgtcta 13920 gcttgctgac gcccaactcg cgcctgttgc tgctgctaat agcgcccttc acggacagtg 13980 gcagcgtgtc ccgggacaca tacctaggtc acttgctgac actgtaccgc gaggccatag 14040 gtcaggcgca tgtggacgag catactttcc aggagattac aagtgtcagc cgcgcgctgg 14100 ggcaggagga cacgggcagc ctggaggcaa ccctaaacta cctgctgacc aaccggcggc 14160 agaagatccc ctcgttgcac agtttaaaca gcgaggagga gcgcattttg cgctacgtgc 14220 agcagagcgt gagccttaac ctgatgcgcg acggggtaac gcccagcgtg gcgctggaca 14280 tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa ccggccgttt atcaaccgcc 14340 taatggacta cttgcatcgc gcggccgccg tgaaccccga gtatttcacc aatgccatct 14400 tgaacccgca ctggctaccg ccccctggtt tctacaccgg gggattcgag gtgcccgagg 14460 gtaacgatgg attcctctgg gacgacatag acgacagcgt gttttccccg caaccgcaga 14520 ccctgctaga gttgcaacag cgcgagcagg cagaggcggc gctgcgaaag gaaagcttcc 14580 gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc gcggtcagat gctagtagcc 14640 catttccaag cttgataggg tctcttacca gcactcgcac cacccgcccg cgcctgctgg 14700 gcgaggagga gtacctaaac aactcgctgc tgcagccgca gcgcgaaaaa aacctgcctc 14760 cggcatttcc caacaacggg atagagagcc tagtggacaa gatgagtaga tggaagacgt 14820 acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc cacccgtcgt caaaggcacg 14880 accgtcagcg gggtctggtg tgggaggacg atgactcggc agacgacagc agcgtcctgg 14940 atttgggagg gagtggcaac ccgtttgcgc accttcgccc caggctgggg agaatgtttt 15000 aaaaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg gcaccgagcg 15060 ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg aaggtcctcc 15120 tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg gttctccctt 15180 cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta ccggggggag 15240 aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg tgtacctggt 15300 ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca gcaactttct 15360 gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac agaccatcaa 15420 tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata ccaacatgcc 15480 aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg tgtcgcgctt 15540 gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca cgctgcccga 15600 gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg tggagcacta 15660 cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa agtttgacac 15720 ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg gggtatatac 15780 aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg acttcaccca 15840 cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg agggctttag 15900 gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg tggacgccta 15960 ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg gcagcaacag 16020 cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc agccggtgga 16080 ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg aggagaagcg 16140 cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg aggtcgagaa 16200 gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac gcagttacaa 16260 cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg catacaacta 16320 cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg acgtaacctg 16380 cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg tgaccttccg 16440 ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc ccgtgcactc 16500 caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt ttacctctct 16560 gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc cagcccccac 16620 catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc taccgctgcg 16680 caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc gcacctgccc 16740 ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc gcactttttg 16800 agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc tgcgcttccc 16860 aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc gcgtgcgcgg 16920 gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca ccaccgtcga 16980 tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc cgccaccagt 17040 gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct atgctaaaat 17100 gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca ctgccgccca 17160 acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg cggccatgcg 17220 ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca ggcgacgagc 17280 ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg gcaacgtgta 17340 ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc ccccgcgcaa 17400 ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag cggcggcggc 17460 gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg tcatcgcgcc 17520 ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa agctaaagcg 17580 ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg aactgctgca 17640 cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac gtgttttgcg 17700 acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct acaagcgcgt 17760 gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc gcctcgggga 17820 gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg agggcaaccc 17880 aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg caccgtccga 17940 agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc agctgatggt 18000 acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac ctgggctgga 18060 gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg tgcagaccgt 18120 ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag agggcatgga 18180 gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg cggtcgctgc 18240 ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc gcgtttcagc 18300 cccccggcgc ccgcgccgtt cgaggaagta cggcgccgcc agcgcgctac tgcccgaata 18360 tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct accgccccag 18420 aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc gtcgccgtcg 18480 ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag gcaggaccct 18540 ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct ttgtggttct 18600 tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc gaggaagaat 18660 gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc gtgcgcacca 18720 ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc tccttattcc 18780 actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct tgcaggcgca 18840 gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt ctggactctc 18900 acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt gcgtctctgg 18960 ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc accagcaata 19020 tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat ttcggttcca 19080 ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg ctgagggata 19140 agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct ggcattagcg 19200 gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag cttgatcccc 19260 gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag gggcgtggcg 19320 aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac gagcctccct 19380 cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg cccatggcta 19440 ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc gccgacaccc 19500 agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct agccgcgcgt 19560 ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt ggcaactggc 19620 aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc cgacgatgct 19680 tctgaatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc gccagaggag 19740 ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga tgccgcagtg 19800 gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg ggctggtgca 19860 gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa accccacggt 19920 ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc ggttcatccc 19980 tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag ctgtgggtga 20040 taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc tggacagggg 20100 ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca agggtgcccc 20160 aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag aagaagagga 20220 cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc acgtatttgg 20280 gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag gtgtcgaagg 20340 tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag gagaatctca 20400 gtggtacgaa actgaaatta atcatgcagc tgggagagtc cttaaaaaga ctaccccaat 20460 gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc aaggcattct 20520 tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt tctcaactac 20580 tgaggcgacc gcaggcaatg gtgataactt gactcctaaa gtggtattgt acagtgaaga 20640 tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta aggaaggtaa 20700 ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca ttgcttttag 20760 ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg ttctggcggg 20820 ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag agctttcata 20880 ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt ggaatcaggc 20940 tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg aagatgaact 21000 tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta ccaaggtaaa 21060 acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt cagataaaaa 21120 tcaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca acctgtggag 21180 aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt acagtccttc 21240 caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc gagtggtggc 21300 tcccgggtta gtggactgct acattaacct tggagcacgc tggtcccttg actatatgga 21360 caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct caatgttgct 21420 gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct ttgccattaa 21480 aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga aggatgttaa 21540 catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca gcattaagtt 21600 tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg cctccacgct 21660 tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc tctccgccgc 21720 caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca tcccctcccg 21780 caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg aaaccccatc 21840 actgggctcg ggctacgacc cttattacac ctactctggc tctataccct acctagatgg 21900 aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact cttctgtcag 21960 ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc gctcagttga 22020 cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc tggtacaaat 22080 gctagctaac tacaacattg gctaccaggg cttctatatc ccagagagct acaaggaccg 22140 catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg atgatactaa 22200 atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg gatttgttgg 22260 ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc cctatccgct 22320 tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg atcgcaccct 22380 ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag acctgggcca 22440 aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg tggatcccat 22500 ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc gtgtgcaccg 22560 gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg ccggcaacgc 22620 cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc cagtgagcag 22680 gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg cacctatgac 22740 aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt caatacggcc 22800 ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca ctcaaaaaca 22860 tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt ttaccagttt 22920 gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg ctgtataacg 22980 ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg actattctgc 23040 tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca caaccccacc 23100 atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt acagcccacc 23160 ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc ctacttccgc 23220 agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa catgtaaaaa 23280 taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac tctcgggtga 23340 ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt ctgccgcgca 23400 tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct ccacttaaac 23460 tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct gcgcaccatc 23520 accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg gcctccgccc 23580 tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag cgccgggtgg 23640 tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc ctccgcgttg 23700 ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc gtgcccaggc 23760 tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt ctgggcgtta 23820 ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc ctttgcgcct 23880 tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca ggccgcgtcg 23940 tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc ccaccggttc 24000 ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt ttcgctcgtc 24060 acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag acacttaagc 24120 tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg ctcgtgatgc 24180 ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc catcatcgtc 24240 acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc gttcagccag 24300 gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa gttcgccttt 24360 agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat gcccttctcc 24420 cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact ttccgcttcg 24480 ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc gtcttcattc 24540 agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg tgggttgctg 24600 aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac gattacctct 24660 ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt gggcgcaatg 24720 gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac cagcgcgtct 24780 tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt ttttgggggc 24840 gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt tgggggacgt 24900 cgcgccgcac cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc ccgactggcc 24960 atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa ggacagccta 25020 accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc gcctaccacc 25080 ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca ggacccaggt 25140 tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa gcaagaccag 25200 gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca tggcgactac 25260 ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc cattatctgc 25320 gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag ccttgcctac 25380 gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg cacatgcgag 25440 cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct tgccacctat 25500 cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg cagccgagcg 25560 gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc gctcaacgaa 25620 gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa cgctctgcaa 25680 caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga gggtgacaac 25740 gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta cccggcactt 25800 aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg ccgtgcgcag 25860 cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc cgcagttggc 25920 gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga ggagcgacgc 25980 aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca gcggttcttt 26040 gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt tcgacagggc 26100 tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt ctcctacctt 26160 ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct caagggcgag 26220 gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac ctggcagacg 26280 gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct gcagaaactg 26340 ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt ggccgcgcac 26400 ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg tctgccagac 26460 ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg ctcaggaatc 26520 ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta ccgcgaatgc 26580 cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct tgcctaccac 26640 tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg tcgctgcaac 26700 ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga aagtcaaatt 26760 atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc tccggggttg 26820 aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc tgaggactac 26880 cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccaaatgc ggagcttacc 26940 gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa caaagcccgc 27000 caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc cggcgaggag 27060 ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc ccttgcttcc 27120 caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg aggaggaata 27180 ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga tggaagactg 27240 ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa caccgtcacc 27300 ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca gcatggctac 27360 aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc gtagatggga 27420 caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc aagagcaaca 27480 acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg cttgcttgca 27540 agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc acggcgtggc 27600 cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact gcaccggcgg 27660 cagcggcagc ggcagcaaca gcagcggcca cacagaagca aaggcgaccg gatagcaaga 27720 ctctgacaaa gcccaagaaa tccacagcgg cggcagcagc aggaggagga gcgctgcgtc 27780 tggcgcccaa cgaacccgta tcgacccgcg agcttagaaa caggattttt cccactctgt 27840 atgctatatt tcaacagagc aggggccaag aacaagagct gaaaataaaa aacaggtctc 27900 tgcgatccct cacccgcagc tgcctgtatc acaaaagcga agatcagctt cggcgcacgc 27960 tggaagacgc ggaggctctc ttcagtaaat actgcgcgct gactcttaag gactagtttc 28020 gcgccctttc tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca cacccggcgc 28080 cagcacctgt cgtcagcgcc atttcaactt tgtatacaaa agttgtgatg agcaaggaaa 28140 ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct ggagctgccc 28200 aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata tcccgggtca 28260 acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt accaccacac 28320 ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg 28380 ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg actaactcag 28440 gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag ggtataactc 28500 acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg 28560 gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca ttcacgcctc 28620 gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga ggcattggaa 28680 ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc tcgggacctc 28740 ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac tcggcggacg 28800 gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact 28860 gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt gaattgcccg 28920 aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga gagcttgccc 28980 gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac aggggaccct 29040 gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat ctttgttgcc 29100 atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc ctatcgccat 29160 cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt acctggtact 29220 tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt gagtctacga 29280 gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct tacctgccgg 29340 gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg taaaccagac 29400 tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc ttagaaaacc 29460 cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt caagcaactc 29520 tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc tctgtcttgt 29580 gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct gctgtgtgca 29640 catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat gattaggtac 29700 ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa ggtggatttt 29760 aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac cactcttata 29820 aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat tggcaagtat 29880 gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac agttttccag 29940 ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg cgacattacc 30000 atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga aaacactggc 30060 actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac cctactctat 30120 attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta atttactaag 30180 ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca aattcaaaaa 30240 gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct caataccatt 30300 cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg aagtcaggct 30360 tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt tccagtccaa 30420 ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc cgctaccgga 30480 cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg ggataacttg 30540 ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat gtggctcatc 30600 tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat tgtgctacac 30660 ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt ttctcttaca 30720 gtatgattaa atgagacatg attcctcgag tttttatatt actgaccctt gttgcgcttt 30780 tttgtgcgtg ctccacattg gctgcggttt ctcacatcga agtagactgc attccagcct 30840 tcacagtcta tttgctttac ggatttgtca ccctcacgct catctgcagc ctcatcactg 30900 tggtcatcgc ctttatccag tgcattgact gggtctgtgt gcgctttgca tatctcagac 30960 accatcccca gtacagggac aggactatag ctgagcttct tagaattctt taattatgaa 31020 atttactgtg acttttctgc tgattatttg caccctatct gcgttttgtt ccccgacctc 31080 caagcctcaa agacatatat catgcagatt cactcgtata tggaatattc caagttgcta 31140 caatgaaaaa agcgatcttt ccgaagcctg gttatatgca atcatctctg ttatggtgtt 31200 ctgcagtacc atcttagccc tagctatata tccctacctt gacattggct ggaacgcaat 31260 agatgccatg aaccacccaa ctttccccgc gcccgctatg cttccactgc aacaagttgt 31320 tgccggcggc tttgtcccag ccaatcagcc tcgcccacct tctcccaccc ccactgaaat 31380 cagctacttt aatctaacag gaggagatga ctgacaccct agatctagaa atggacggaa 31440 ttattacaga gcagcgcctg ctagaaagac gcagggcagc ggccgagcaa cagcgcatga 31500 atcaagagct ccaagacatg gttaacttgc accagtgcaa aaggggtatc ttttgtctgg 31560 taaagcaggc caaagtcacc tacgacagta ataccaccgg acaccgcctt agctacaagt 31620 tgccaaccaa gcgtcagaaa ttggtggtca tggtgggaga aaagcccatt accataactc 31680 agcactcggt agaaaccgaa ggctgcattc actcaccttg tcaaggacct gaggatctct 31740 gcacccttat taagaccctg tgcggtctca aagatcttat tccctttaac taataaaaaa 31800 aaataataaa gcatcactta cttaaaatca gttagcaaat ttctgtccag tttattcagc 31860 agcacctcct tgccctcctc ccagctctgg tattgcagct tcctcctggc tgcaaacttt 31920 ctccacaatc taaatggaat gtcagtttcc tcctgttcct gtccatccgc acccactatc 31980 ttcatgttgt tgcagatgaa gcgcgcaaga ccgtctgaag ataccttcaa ccccgtgtat 32040 ccatatgaca cggaaaccgg tcctccaact gtgccttttc ttactcctcc ctttgtatcc 32100 cccaatgggt ttcaagagag tccccctggg gtactctctt tgcgcctatc cgaacctcta 32160 gttacctcca atggcatgct tgcgctcaaa atgggcaacg gcctctctct ggacgaggcc 32220 ggcaacctta cctcccaaaa tgtaaccact gtgagcccac ctctcaaaaa aaccaagtca 32280 aacataaacc tggaaatatc tgcacccctc acagttacct cagaagccct aactgtggct 32340 gccgccgcac ctctaatggt cgcgggcaac acactcacca tgcaatcaca ggccccgcta 32400 accgtgcacg actccaaact tagcattgcc acccaaggac ccctcacagt gtcagaagga 32460 aagctagccc tgcaaacatc aggccccctc accaccaccg atagcagtac ccttactatc 32520 actgcctcac cccctctaac tactgccact ggtagcttgg gcattgactt gaaagagccc 32580 atttatacac aaaatggaaa actaggacta aagtacgggg ctcctttgca tgtaacagac 32640 gacctaaaca ctttgaccgt agcaactggt ccaggtgtga ctattaataa tacttccttg 32700 caaactaaag ttactggagc cttgggtttt gattcacaag gcaatatgca acttaatgta 32760 gcaggaggac taaggattga ttctcaaaac agacgcctta tacttgatgt tagttatccg 32820 tttgatgctc aaaaccaact aaatctaaga ctaggacagg gccctctttt tataaactca 32880 gcccacaact tggatattaa ctacaacaaa ggcctttact tgtttacagc ttcaaacaat 32940 tccaaaaagc ttgaggttaa cctaagcact gccaaggggt tgatgtttga cgctacagcc 33000 atagccatta atgcaggaga tgggcttgaa tttggttcac ctaatgcacc aaacacaaat 33060 cccctcaaaa caaaaattgg ccatggccta gaatttgatt caaacaaggc tatggttcct 33120 aaactaggaa ctggccttag ttttgacagc acaggtgcca ttacagtagg aaacaaaaat 33180 aatgataagc taactttatg gacaggtcca aaaccagaag ccaactgcat aattgaatac 33240 gggaaacaaa acccagatag caaactaact ttaatccttg taaaaaatgg aggaattgtt 33300 aatggatatg taacgctaat gggagcctca gactacgtta acaccttatt taaaaacaaa 33360 aatgtctcca ttaatgtaga actatacttt gatgccactg gtcatatatt accagactca 33420 tcttctctta aaacagatct agaactaaaa tacaagcaaa ccgctgactt tagtgcaaga 33480 ggttttatgc caagtactac agcgtatcca tttgtccttc ctaatgcggg aacacataat 33540 gaaaattata tttttggtca atgctactac aaagcaagcg atggtgccct ttttccgttg 33600 gaagttactg ttatgcttaa taaacgcctg ccagatagtc gcacatccta tgttatgact 33660 tttttatggt ccttgaatgc tggtctagct ccagaaacta ctcaggcaac cctcataacc 33720 tccccattta ccttttccta tattagagaa gatgactaat aaagaatcgt ttgtgttatg 33780 tttcaacgtg tttatttttc aattgcagaa aatttcaagt catttttcat tcagtagtat 33840 agccccacca ccacatagct tatacagatc accgtacctc aactttgtat aataaagttg 33900 taatcaaact cacagaaccc tagtattcaa cctgccacct ccctcccaac acacagagta 33960 cacagtcctt tctccccggc tggccttaaa aagcatcata tcatgggtaa cagacatatt 34020 cttaggtgtt atattccaca cggtttcctg tcgagccaaa cgctcatcag tgatattaat 34080 aaactccccg ggcagctcac ttaagttcat gtcgctgtcc agctgctgag ccacaggctg 34140 ctgtccaact tgcggttgct taacgggcgg cgaaggagaa gtccacgcct acatgggggt 34200 agagtcataa tcgtgcatca ggatagggcg gtggtgctgc agcagcgcgc gaataaactg 34260 ctgccgccgc cgctccgtcc tgcaggaata caacatggca gtggtctcct cagcgatgat 34320 tcgcaccgcc cgcagcataa ggcgccttgt cctccgggca cagcagcgca ccctgatctc 34380 acttaaatca gcacagtaac tgcagcacag caccacaata ttgttcaaaa tcccacagtg 34440 caaggcgctg tatccaaagc tcatggcggg gaccacagaa cccacgtggc catcatacca 34500 caagcgcagg tagattaagt ggcgacccct cataaacacg ctggacataa acattacctc 34560 ttttggcatg ttgtaattca ccacctcccg gtaccatata aacctctgat taaacatggc 34620 gccatccacc accatcctaa accagctggc caaaacctgc ccgccggcta tacactgcag 34680 ggaaccggga ctggaacaat gacagtggag agcccaggac tcgtaaccat ggatcatcat 34740 gctcgtcatg atatcaatgt tggcacaaca caggcacacg tgcatacact tcctcaggat 34800 tacaagctcc tcccgcgtta gaaccatatc ccagggaaca acccattcct gaatcagcgt 34860 aaatcccaca ctgcagggaa gacctcgcac gtaactcacg ttgtgcattg tcaaagtgtt 34920 acattcgggc agcagcggat gatcctccag tatggtagcg cgggtttctg tctcaaaagg 34980 aggtagacga tccctactgt acggagtgcg ccgagacaac cgagatcgtg ttggtcgtag 35040 tgtcatgcca aatggaacgc cggacgtagt catatttcct gaagcaaaac caggtgcggg 35100 cgtgacaaac agatctgcgt ctccggtctc gccgcttaga tcgctctgtg tagtagttgt 35160 agtatatcca ctctctcaaa gcatccaggc gccccctggc ttcgggttct atgtaaactc 35220 cttcatgcgc cgctgccctg ataacatcca ccaccgcaga ataagccaca cccagccaac 35280 ctacacattc gttctgcgag tcacacacgg gaggagcggg aagagctgga agaaccatgt 35340 tttttttttt attccaaaag attatccaaa acctcaaaat gaagatctat taagtgaacg 35400 cgctcccctc cggtggcgtg gtcaaactct acagccaaag aacagataat ggcatttgta 35460 agatgttgca caatggcttc caaaaggcaa acggccctca cgtccaagtg gacgtaaagg 35520 ctaaaccctt cagggtgaat ctcctctata aacattccag caccttcaac catgcccaaa 35580 taattctcat ctcgccacct tctcaatata tctctaagca aatcccgaat attaagtccg 35640 gccattgtaa aaatctgctc cagagcgccc tccaccttca gcctcaagca gcgaatcatg 35700 attgcaaaaa ttcaggttcc tcacagacct gtataagatt caaaagcgga acattaacaa 35760 aaataccgcg atcccgtagg tcccttcgca gggccagctg aacataatcg tgcaggtctg 35820 cacggaccag cgcggccact tccccgccag gaaccatgac aaaagaaccc acactgatta 35880 tgacacgcat actcggagct atgctaacca gcgtagcccc gatgtaagct tgttgcatgg 35940 gcggcgatat aaaatgcaag gtgctgctca aaaaatcagg caaagcctcg cgcaaaaaag 36000 aaagcacatc gtagtcatgc tcatgcagat aaaggcaggt aagctccgga accaccacag 36060 aaaaagacac catttttctc tcaaacatgt ctgcgggttt ctgcataaac acaaaataaa 36120 ataacaaaaa aacatttaaa cattagaagc ctgtcttaca acaggaaaaa caacccttat 36180 aagcataaga cggactacgg ccatgccggc gtgaccgtaa aaaaactggt caccgtgatt 36240 aaaaagcacc accgacagct cctcggtcat gtccggagtc ataatgtaag actcggtaaa 36300 cacatcaggt tgattcacat cggtcagtgc taaaaagcga ccgaaatagc ccgggggaat 36360 acatacccgc aggcgtagag acaacattac agcccccata ggaggtataa caaaattaat 36420 aggagagaaa aacacataaa cacctgaaaa accctcctgc ctaggcaaaa tagcaccctc 36480 ccgctccaga acaacataca gcgcttccac agcggcagcc ataacagtca gccttaccag 36540 taaaaaagaa aacctattaa aaaaacacca ctcgacacgg caccagctca atcagtcaca 36600 gtgtaaaaaa gggccaagtg cagagcgagt atatatagga ctaaaaaatg acgtaacggt 36660 taaagtccac aaaaaacacc cagaaaaccg cacgcgaacc tacgcccaga aacgaaagcc 36720 aaaaaaccca caacttcctc aaatcgtcac ttccgttttc ccacgttacg tcacttccca 36780 ttttaagaaa actacaattc ccaacacata caagttactc cgccctaaaa cctacgtcac 36840 ccgccccgtt cccacgcccc gcgccacgtc acaaactcca ccccctcatt atcatattgg 36900 cttcaatcca aaataaggta tattattgat gatg 36934 <210> 70 <211> 36916 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO173) <400> 70 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattaaac cgtattaccg ccatgcattt aatggagtgc 480 ctcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa 540 gttgggggga ggggtcggca attgaaccgg tgcctagaga aggtggcgcg gggtaaactg 600 ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat 660 aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacaggt 720 aagtgccgtg tgtggttccc gcgggcctgg cctctttacg ggttatggcc cttgcgtgcc 780 ttgaattact tccacctggc tgcagtacgt gattcttgat cccgagcttc gggttggaag 840 tgggtgggag agttcgaggc cttgcgctta aggagcccct tcgcctcgtg cttgagttga 900 ggcctggcct gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct 960 cgctgctttc gataagtctc tagccattta aaatttttga tgacctgctg cgacgctttt 1020 tttctggcaa gatagtcttg taaatgcggg ccaagatctg cacactggta tttcggtttt 1080 tggggccgcg ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg 1140 cctgcgagcg cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct 1200 ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc 1260 ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag ggagctcaaa 1320 atggaggacg cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc 1380 ctttccgtcc tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca 1440 cctcgattag ttctcgagct tttggagtac gtcgtcttta ggttgggggg aggggtttta 1500 tgcgatggag tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt 1560 gatgtaattc tccttggaat ttgccctttt tgagtttgga tcttggttca ttctcaagcc 1620 tcagacagtg gttcaaagtt tttttcttcc atttcaggtg tcgtgacgct agcgctaccg 1680 gactcagatc tcgagctcaa gcttcgaatt ctgcagtcga cggtaccgga tccatggaag 1740 acgccaaaaa cataaagaaa ggcccggcgc cattctatcc gctggaagat ggaaccgctg 1800 gagagcaact gcataaggct atgaagagat acgccctggt tcctggaaca attgctttta 1860 cagatgcaca tatcgaggtg gacatcactt acgctgagta cttcgaaatg tccgttcggt 1920 tggcagaagc tatgaaacga tatgggctga atacaaatca cagaatcgtc gtatgcagtg 1980 aaaactctct tcaattcttt atgccggtgt tgggcgcgtt atttatcgga gttgcagttg 2040 cgcccgcgaa cgacatttat aatgaacgtg aattgctcaa cagtatgggc atttcgcagc 2100 ctaccgtggt gttcgtttcc aaaaaggggt tgcaaaaaat tttgaacgtg caaaaaaagc 2160 tcccaatcat ccaaaaaatt attatcatgg attctaaaac ggattaccag ggatttcagt 2220 cgatgtacac gttcgtcaca tctcatctac ctcccggttt taatgaatac gattttgtgc 2280 cagagtcctt cgatagggac aagacaattg cactgatcat gaactcctct ggatctactg 2340 gtctgcctaa aggtgtcgct ctgcctcata gaactgcctg cgtgagattc tcgcatgcca 2400 gagatcctat ttttggcaat caaatcattc cggatactgc gattttaagt gttgttccat 2460 tccatcacgg ttttggaatg tttactacac tcggatattt gatatgtgga tttcgagtcg 2520 tcttaatgta tagatttgaa gaagagctgt ttctgaggag ccttcaggat tacaagattc 2580 aaagtgcgct gctggtgcca accctattct ccttcttcgc caaaagcact ctgattgaca 2640 aatacgattt atctaattta cacgaaattg cttctggtgg cgctcccctc tctaaggaag 2700 tcggggaagc ggttgccaag aggttccatc tgccaggtat caggcaagga tatgggctca 2760 ctgagactac atcagctatt ctgattacac ccgaggggga tgataaaccg ggcgcggtcg 2820 gtaaagttgt tccatttttt gaagcgaagg ttgtggatct ggataccggg aaaacgctgg 2880 gcgttaatca aagaggcgaa ctgtgtgtga gaggtcctat gattatgtcc ggttatgtaa 2940 acaatccgga agcgaccaac gccttgattg acaaggatgg atggctacat tctggagaca 3000 tagcttactg ggacgaagac gaacacttct tcatcgttga ccgcctgaag tctctgatta 3060 agtacaaagg ctatcaggtg gctcccgctg aattggaatc catcttgctc caacacccca 3120 acatcttcga cgcaggtgtc gcaggtcttc ccgacgatga cgccggtgaa cttcccgccg 3180 ccgttgttgt tttggagcac ggaaagacga tgacggaaaa agagatcgtg gattacgtcg 3240 ccagtcaagt aacaaccgcg aaaaagttgc gcggaggagt tgtgtttgtg gacgaagtac 3300 cgaaaggtct taccggaaaa ctcgacgcaa gaaaaatcag agagatcctc ataaaggcca 3360 agaagggcgg aaagatcgcc gtggcagccg cagccaccat ggtgagcaag ggcgaggagc 3420 tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt 3480 tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca 3540 tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg 3600 gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg 3660 ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca 3720 agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg 3780 gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca 3840 gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga 3900 tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc 3960 ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc 4020 tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg 4080 ccgggatcac tctcggcatg gacgagctgt acaagtaaag cgactctaga tcataatcag 4140 ccatacccaa acaccattgt cacactccaa tcgattcaaa caccattgtc acactccaac 4200 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4260 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4320 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4380 tttgtccaaa ctcatcaatg taagtttaaa cggcgcgcct gaaatgtgtg ggcgtggctt 4440 aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct gttttgcagc 4500 agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct catatttgac 4560 aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca gcattgatgg 4620 tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt ctggaacgcc 4680 gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc gcgggattgt 4740 gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt catccgcccg 4800 cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg aacttaatgt 4860 cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg cttcctcccc 4920 tcccaatgcg gtttaaaaca caacttttct atacaaagtt gtaaataaaa aaccagactc 4980 tgtttggatt tggatcaagc taagtgtctt gctgtcttta tttaggggtt ttgcgcgcgc 5040 ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct gtgtattttt tccaggacgt 5100 ggtaaaggtg actctggatg ttcagataca tgggcataag cccgtctctg gggtggaggt 5160 agcaccactg cagagcttca tgctgcgggg tggtgttgta gatgatccag tcgtagcagg 5220 agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa gctgattgcc aggggcaggc 5280 ccttggtgta agtgtttaca aagcggttaa gctgggatgg gtgcatacgt ggggatatga 5340 gatgcatctt ggactgtatt tttaggttgg ctatgttccc agccatatcc ctccggggat 5400 tcatgttgtg cagaaccacc agcacagtgt atccggtgca cttgggaaat ttgtcatgta 5460 gcttagaagg aaatgcgtgg aagaacttgg agacgccctt gtgacctcca agattttcca 5520 tgcattcgtc cataatgatg gcaatgggcc cacgggcggc ggcctgggcg aagatatttc 5580 tgggatcact aacgtcatag ttgtgttcca ggatgagatc gtcataggcc atttttacaa 5640 agcgcgggcg gagggtgcca gactgcggta taatggttcc atccggccca ggggcgtagt 5700 taccctcaca gatttgcatt tcccacgctt tgagttcaga tggggggatc atgtctacct 5760 gcggggcgat gaagaaaacg gtttccgggg taggggagat cagctgggaa gaaagcaggt 5820 tcctgagcag ctgcgactta ccgcagccgg tgggcccgta aatcacacct attaccggct 5880 gcaactggta gttaagagag ctgcagctgc cgtcatccct gagcaggggg gccacttcgt 5940 taagcatgtc cctgactcgc atgttttccc tgaccaaatc cgccagaagg cgctcgccgc 6000 ccagcgatag cagttcttgc aaggaagcaa agtttttcaa cggtttgaga ccgtccgccg 6060 taggcatgct tttgagcgtt tgaccaagca gttccaggcg gtcccacagc tcggtcacct 6120 gctctacggc atctcgatcc agcatatctc ctcgtttcgc gggttggggc ggctttcgct 6180 gtacggcagt agtcggtgct cgtccagacg ggccagggtc atgtctttcc acgggcgcag 6240 ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc gctccgggct gcgcgctggc 6300 cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc tgccggtctt cgccctgcgc 6360 gtcggccagg tagcatttga ccatggtgtc atagtccagc ccctccgcgg cgtggccctt 6420 ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg cagtgcagac ttttgagggc 6480 gtagagcttg ggcgcgagaa ataccgattc cggggagtag gcatccgcgc cgcaggcccc 6540 gcagacggtc tcgcattcca cgagccaggt gagctctggc cgttcggggt caaaaaccag 6600 gtttccccca tgctttttga tgcgtttctt acctctggtt tccatgagcc ggtgtccacg 6660 ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac ttgagaggcc tgtcctcgag 6720 cggtgttccg cggtcctcct cgtatagaaa ctcggaccac tctgagacaa aggctcgcgt 6780 ccaggccagc acgaaggagg ctaagtggga ggggtagcgg tcgttgtcca ctagggggtc 6840 cactcgctcc agggtgtgaa gacacatgtc gccctcttcg gcatcaagga aggtgattgg 6900 tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg gggctataaa agggggtggg 6960 ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg agggccagct gttggggtga 7020 gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga ttgtcagttt ccaaaaacga 7080 ggaggatttg atattcacct ggcccgcggt gatgcctttg agggtggccg catccatctg 7140 gtcagaaaag acaatctttt tgttgtcaag cttggtggca aacgacccgt agagggcgtt 7200 ggacagcaac ttggcgatgg agcgcagggt ttggtttttg tcgcgatcgg cgcgctcctt 7260 ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac cgccattcgg gaaagacggt 7320 ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg ttgtgcaggg tgacaaggtc 7380 aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc cagcagaggc ggccgccctt 7440 gcgcgagcag aatggcggta gggggtctag ctgcgtctcg tccggggggt ctgcgtccac 7500 ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct atcttgcatc cttgcaagtc 7560 tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg tatgggttga gtgggggacc 7620 ccatggcatg gggtgggtga gcgcggaggc gtacatgccg caaatgtcgt aaacgtagag 7680 gggctctctg agtattccaa gatatgtagg gtagcatctt ccaccgcgga tgctggcgcg 7740 cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg ggaccgaggt tgctacgggc 7800 gggctgctct gctcggaaga ctatctgcct gaagatggca tgtgagttgg atgatatggt 7860 tggacgctgg aagacgttga agctggcgtc tgtgagacct accgcgtcac gcacgaagga 7920 ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg acctgcacgt ctagggcgca 7980 gtagtccagg gtttccttga tgatgtcata cttatcctgt cccttttttt tccacagctc 8040 gcggttgagg acaaactctt cgcggtcttt ccagtactct tggatcggaa acccgtcggc 8100 ctccgaacgg taagagccta gcatgtagaa ctggttgacg gcctggtagg cgcagcatcc 8160 cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg agcgaggtgt gggtgagcgc 8220 aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg aagtcagtgt cgtcgcatcc 8280 gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa cgcggatttg gcagggcgaa 8340 ggtgacatcg ttgaagagta tctttcccgc gcgaggcata aagttgcgtg tgatgcggaa 8400 gggtcccggc acctcggaac ggttgttaat tacctgggcg gcgagcacga tctcgtcaaa 8460 gccgttgatg ttgtggccca caatgtaaag ttccaagaag cgcgggatgc ccttgatgga 8520 aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg gagctgagcc cgtgctctga 8580 aagggcccag tctgcaagat gagggttgga agcgacgaat gagctccaca ggtcacgggc 8640 cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg cgacctatgg ccattttttc 8700 tggggtgatg cagtagaagg taagcgggtc ttgttcccag cggtcccatc caaggttcgc 8760 ggctaggtct cgcgcggcag tcactagagg ctcatctccg ccgaacttca tgaccagcat 8820 gaagggcacg agctgcttcc caaaggcccc catccaagta taggtctcta catcgtaggt 8880 gacaaagaga cgctcggtgc gaggatgcga gccgatcggg aagaactgga tctcccgcca 8940 ccaattggag gagtggctat tgatgtggtg aaagtagaag tccctgcgac gggccgaaca 9000 ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag cggtgcacgg gctgtacatc 9060 ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag agtgggaatt tgagcccctc 9120 gcctggcggg tttggctggt ggtcttctac ttcggctgct tgtccttgac cgtctggctg 9180 ctcgagggga gttacggtgg atcggaccac cacgccgcgc gagcccaaag tccagatgtc 9240 cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga tgggagctgt ccatggtctg 9300 gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg tttacctcgc atagacgggt 9360 cagggcgcgg gctagatcca ggtgatacct aatttccagg ggctggttgg tggcggcgtc 9420 gatggcttgc aagaggccgc atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg 9480 ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt gacgcgggcg agcccccgga 9540 ggtagggggg gctccggacc cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg 9600 ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc 9660 tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag 9720 agttcgacag aatcaatttc ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg 9780 tctcctgagt tgtcttgata ggcgatctcg gccatgaact gctcgatctc ttcctcctgg 9840 agatctccgc gtccggctcg ctccacggtg gcggcgaggt cgttggaaat gcgggccatg 9900 agctgcgaga aggcgttgag gcctccctcg ttccagacgc ggctgtagac cacgccccct 9960 tcggcatcgc gggcgcgcat gaccacctgc gcgagattga gctccacgtg ccgggcgaag 10020 acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc 10080 acgaagaagt acataaccca gcgtcgcaac gtggattcgt tgatatcccc caaggcctca 10140 aggcgctcca tggcctcgta gaagtccacg gcgaagttga aaaactggga gttgcgcgcc 10200 gacacggtta actcctcctc cagaagacgg atgagctcgg cgacagtgtc gcgcacctcg 10260 cgctcaaagg ctacaggggc ctcttcttct tcttcaatct cctcttccat aagggcctcc 10320 ccttcttctt cttctggcgg cggtggggga ggggggacac ggcggcgacg acggcgcacc 10380 gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc gacggcgcat ggtctcggtg 10440 acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc cgcccgtcat gtcccggtta 10500 tgggttggcg gggggctgcc atgcggcagg gatacggcgc taacgatgca tctcaacaat 10560 tgttgtgtag gtactccgcc gccgagggac ctgagcgagt ccgcatcgac cggatcggaa 10620 aacctctcga gaaaggcgtc taaccagtca cagtcgcaag gtaggctgag caccgtggcg 10680 ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg tgctgctgat gatgtaatta 10740 aagtaggcgg tcttgagacg gcggatggtc gacagaagca ccatgtcctt gggtccggcc 10800 tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt tttgacatcg gcgcaggtct 10860 ttgtagtagt cttgcatgag cctttctacc ggcacttctt cttctccttc ctcttgtcct 10920 gcatctcttg catctatcgc tgcggcggcg gcggagtttg gccgtaggtg gcgccctctt 10980 cctcccatgc gtgtgacccc gaagcccctc atcggctgaa gcagggctag gtcggcgaca 11040 acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg tagactggaa gtcatccatg 11100 tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag tgcagttggc cataacggac 11160 cagttaacgg tctggtgacc cggctgcgag agctcggtgt acctgagacg cgagtaagcc 11220 ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt actggtatcc caccaaaaag 11280 tgcggcggcg gctggcggta gaggggccag cgtagggtgg ccggggctcc gggggcgaga 11340 tcttccaaca taaggcgatg atatccgtag atgtacctgg acatccaggt gatgccggcg 11400 gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc agatgttgcg cagcggcaaa 11460 aagtgctcca tggtcgggac gctctggccg gtcaggcgcg cgcaatcgtt gacgctctag 11520 accgtgcaaa aggagagcct gtaagcgggc actcttccgt ggtctggtgg ataaattcgc 11580 aagggtatca tggcggacga ccggggttcg agccccgtat ccggccgtcc gccgtgatcc 11640 atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg tcagacaacg ggggagtgct 11700 ccttttggct tccttccagg cgcggcggct gctgcgctag cttttttggc cactggccgc 11760 gcgcagcgta agcggttagg ctggaaagcg aaagcattaa gtggctcgct ccctgtagcc 11820 ggagggttat tttccaaggg ttgagtcgcg ggacccccgg ttcgagtctc ggaccggccg 11880 gactgcggcg aacgggggtt tgcctccccg tcatgcaaga ccccgcttgc aaattcctcc 11940 ggaaacaggg acgagcccct tttttgcttt tcccagatgc atccggtgct gcggcagatg 12000 cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc agacatgcag ggcaccctcc 12060 cctcctccta ccgcgtcagg aggggcgaca tccgcggttg acgcggcagc agatggtgat 12120 tacgaacccc cgcggcgccg ggcccggcac tacctggact tggaggaggg cgagggcctg 12180 gcgcggctag gagcgccctc tcctgagcgg cacccaaggg tgcagctgaa gcgtgatacg 12240 cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc gcgagggaga ggagcccgag 12300 gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc ggcatggcct gaatcgcgag 12360 cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa ccgggattag tcccgcgcgc 12420 gcacacgtgg cggccgccga cctggtaacc gcatacgagc agacggtgaa ccaggagatt 12480 aactttcaaa aaagctttaa caaccacgtg cgtacgcttg tggcgcgcga ggaggtggct 12540 ataggactga tgcatctgtg ggactttgta agcgcgctgg agcaaaaccc aaatagcaag 12600 ccgctcatgg cgcagctgtt ccttatagtg cagcacagca gggacaacga ggcattcagg 12660 gatgcgctgc taaacatagt agagcccgag ggccgctggc tgctcgattt gataaacatc 12720 ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg ctgacaaggt ggccgccatc 12780 aactattcca tgcttagcct gggcaagttt tacgcccgca agatatacca taccccttac 12840 gttcccatag acaaggaggt aaagatcgag gggttctaca tgcgcatggc gctgaaggtg 12900 cttaccttga gcgacgacct gggcgtttat cgcaacgagc gcatccacaa ggccgtgagc 12960 gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc acagcctgca aagggccctg 13020 gctggcacgg gcagcggcga tagagaggcc gagtcctact ttgacgcggg cgctgacctg 13080 cgctgggccc caagccgacg cgccctggag gcagctgggg ccggacctgg gctggcggtg 13140 gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat atgacgagga cgatgagtac 13200 gagccagagg acggcgagta ctaagcggtg atgtttctga tcagatgatg caagacgcaa 13260 cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc cggccttaac tccacggacg 13320 actggcgcca ggtcatggac cgcatcatgt cgctgactgc gcgcaatcct gacgcgttcc 13380 ggcagcagcc gcaggccaac cggctctccg caattctgga agcggtggtc ccggcgcgcg 13440 caaaccccac gcacgagaag gtgctggcga tcgtaaacgc gctggccgaa aacagggcca 13500 tccggcccga cgaggccggc ctggtctacg acgcgctgct tcagcgcgtg gctcgttaca 13560 acagcggcaa cgtgcagacc aacctggacc ggctggtggg ggatgtgcgc gaggccgtgg 13620 cgcagcgtga gcgcgcgcag cagcagggca acctgggctc catggttgca ctaaacgcct 13680 tcctgagtac acagcccgcc aacgtgccgc ggggacagga ggactacacc aactttgtga 13740 gcgcactgcg gctaatggtg actgagacac cgcaaagtga ggtgtaccag tctgggccag 13800 actatttttt ccagaccagt agacaaggcc tgcagaccgt aaacctgagc caggctttca 13860 aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg cgaccgcgcg accgtgtcta 13920 gcttgctgac gcccaactcg cgcctgttgc tgctgctaat agcgcccttc acggacagtg 13980 gcagcgtgtc ccgggacaca tacctaggtc acttgctgac actgtaccgc gaggccatag 14040 gtcaggcgca tgtggacgag catactttcc aggagattac aagtgtcagc cgcgcgctgg 14100 ggcaggagga cacgggcagc ctggaggcaa ccctaaacta cctgctgacc aaccggcggc 14160 agaagatccc ctcgttgcac agtttaaaca gcgaggagga gcgcattttg cgctacgtgc 14220 agcagagcgt gagccttaac ctgatgcgcg acggggtaac gcccagcgtg gcgctggaca 14280 tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa ccggccgttt atcaaccgcc 14340 taatggacta cttgcatcgc gcggccgccg tgaaccccga gtatttcacc aatgccatct 14400 tgaacccgca ctggctaccg ccccctggtt tctacaccgg gggattcgag gtgcccgagg 14460 gtaacgatgg attcctctgg gacgacatag acgacagcgt gttttccccg caaccgcaga 14520 ccctgctaga gttgcaacag cgcgagcagg cagaggcggc gctgcgaaag gaaagcttcc 14580 gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc gcggtcagat gctagtagcc 14640 catttccaag cttgataggg tctcttacca gcactcgcac cacccgcccg cgcctgctgg 14700 gcgaggagga gtacctaaac aactcgctgc tgcagccgca gcgcgaaaaa aacctgcctc 14760 cggcatttcc caacaacggg atagagagcc tagtggacaa gatgagtaga tggaagacgt 14820 acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc cacccgtcgt caaaggcacg 14880 accgtcagcg gggtctggtg tgggaggacg atgactcggc agacgacagc agcgtcctgg 14940 atttgggagg gagtggcaac ccgtttgcgc accttcgccc caggctgggg agaatgtttt 15000 aaaaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg gcaccgagcg 15060 ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg aaggtcctcc 15120 tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg gttctccctt 15180 cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta ccggggggag 15240 aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg tgtacctggt 15300 ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca gcaactttct 15360 gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac agaccatcaa 15420 tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata ccaacatgcc 15480 aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg tgtcgcgctt 15540 gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca cgctgcccga 15600 gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg tggagcacta 15660 cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa agtttgacac 15720 ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg gggtatatac 15780 aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg acttcaccca 15840 cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg agggctttag 15900 gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg tggacgccta 15960 ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg gcagcaacag 16020 cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc agccggtgga 16080 ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg aggagaagcg 16140 cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg aggtcgagaa 16200 gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac gcagttacaa 16260 cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg catacaacta 16320 cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg acgtaacctg 16380 cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg tgaccttccg 16440 ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc ccgtgcactc 16500 caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt ttacctctct 16560 gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc cagcccccac 16620 catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc taccgctgcg 16680 caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc gcacctgccc 16740 ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc gcactttttg 16800 agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc tgcgcttccc 16860 aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc gcgtgcgcgg 16920 gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca ccaccgtcga 16980 tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc cgccaccagt 17040 gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct atgctaaaat 17100 gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca ctgccgccca 17160 acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg cggccatgcg 17220 ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca ggcgacgagc 17280 ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg gcaacgtgta 17340 ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc ccccgcgcaa 17400 ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag cggcggcggc 17460 gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg tcatcgcgcc 17520 ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa agctaaagcg 17580 ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg aactgctgca 17640 cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac gtgttttgcg 17700 acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct acaagcgcgt 17760 gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc gcctcgggga 17820 gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg agggcaaccc 17880 aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg caccgtccga 17940 agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc agctgatggt 18000 acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac ctgggctgga 18060 gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg tgcagaccgt 18120 ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag agggcatgga 18180 gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg cggtcgctgc 18240 ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc gcgtttcagc 18300 cccccggcgc ccgcgccgtt cgaggaagta cggcgccgcc agcgcgctac tgcccgaata 18360 tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct accgccccag 18420 aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc gtcgccgtcg 18480 ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag gcaggaccct 18540 ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct ttgtggttct 18600 tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc gaggaagaat 18660 gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc gtgcgcacca 18720 ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc tccttattcc 18780 actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct tgcaggcgca 18840 gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt ctggactctc 18900 acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt gcgtctctgg 18960 ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc accagcaata 19020 tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat ttcggttcca 19080 ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg ctgagggata 19140 agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct ggcattagcg 19200 gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag cttgatcccc 19260 gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag gggcgtggcg 19320 aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac gagcctccct 19380 cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg cccatggcta 19440 ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc gccgacaccc 19500 agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct agccgcgcgt 19560 ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt ggcaactggc 19620 aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc cgacgatgct 19680 tctgaatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc gccagaggag 19740 ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga tgccgcagtg 19800 gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg ggctggtgca 19860 gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa accccacggt 19920 ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc ggttcatccc 19980 tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag ctgtgggtga 20040 taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc tggacagggg 20100 ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca agggtgcccc 20160 aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag aagaagagga 20220 cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc acgtatttgg 20280 gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag gtgtcgaagg 20340 tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag gagaatctca 20400 gtggtacgaa actgaaatta atcatgcagc tgggagagtc cttaaaaaga ctaccccaat 20460 gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc aaggcattct 20520 tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt tctcaactac 20580 tgaggcgacc gcaggcaatg gtgataactt gactcctaaa gtggtattgt acagtgaaga 20640 tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta aggaaggtaa 20700 ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca ttgcttttag 20760 ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg ttctggcggg 20820 ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag agctttcata 20880 ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt ggaatcaggc 20940 tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg aagatgaact 21000 tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta ccaaggtaaa 21060 acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt cagataaaaa 21120 tcaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca acctgtggag 21180 aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt acagtccttc 21240 caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc gagtggtggc 21300 tcccgggtta gtggactgct acattaacct tggagcacgc tggtcccttg actatatgga 21360 caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct caatgttgct 21420 gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct ttgccattaa 21480 aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga aggatgttaa 21540 catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca gcattaagtt 21600 tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg cctccacgct 21660 tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc tctccgccgc 21720 caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca tcccctcccg 21780 caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg aaaccccatc 21840 actgggctcg ggctacgacc cttattacac ctactctggc tctataccct acctagatgg 21900 aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact cttctgtcag 21960 ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc gctcagttga 22020 cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc tggtacaaat 22080 gctagctaac tacaacattg gctaccaggg cttctatatc ccagagagct acaaggaccg 22140 catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg atgatactaa 22200 atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg gatttgttgg 22260 ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc cctatccgct 22320 tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg atcgcaccct 22380 ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag acctgggcca 22440 aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg tggatcccat 22500 ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc gtgtgcaccg 22560 gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg ccggcaacgc 22620 cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc cagtgagcag 22680 gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg cacctatgac 22740 aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt caatacggcc 22800 ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca ctcaaaaaca 22860 tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt ttaccagttt 22920 gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg ctgtataacg 22980 ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg actattctgc 23040 tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca caaccccacc 23100 atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt acagcccacc 23160 ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc ctacttccgc 23220 agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa catgtaaaaa 23280 taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac tctcgggtga 23340 ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt ctgccgcgca 23400 tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct ccacttaaac 23460 tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct gcgcaccatc 23520 accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg gcctccgccc 23580 tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag cgccgggtgg 23640 tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc ctccgcgttg 23700 ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc gtgcccaggc 23760 tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt ctgggcgtta 23820 ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc ctttgcgcct 23880 tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca ggccgcgtcg 23940 tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc ccaccggttc 24000 ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt ttcgctcgtc 24060 acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag acacttaagc 24120 tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg ctcgtgatgc 24180 ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc catcatcgtc 24240 acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc gttcagccag 24300 gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa gttcgccttt 24360 agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat gcccttctcc 24420 cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact ttccgcttcg 24480 ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc gtcttcattc 24540 agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg tgggttgctg 24600 aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac gattacctct 24660 ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt gggcgcaatg 24720 gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac cagcgcgtct 24780 tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt ttttgggggc 24840 gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt tgggggacgt 24900 cgcgccgcac cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc ccgactggcc 24960 atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa ggacagccta 25020 accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc gcctaccacc 25080 ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca ggacccaggt 25140 tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa gcaagaccag 25200 gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca tggcgactac 25260 ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc cattatctgc 25320 gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag ccttgcctac 25380 gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg cacatgcgag 25440 cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct tgccacctat 25500 cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg cagccgagcg 25560 gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc gctcaacgaa 25620 gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa cgctctgcaa 25680 caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga gggtgacaac 25740 gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta cccggcactt 25800 aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg ccgtgcgcag 25860 cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc cgcagttggc 25920 gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga ggagcgacgc 25980 aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca gcggttcttt 26040 gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt tcgacagggc 26100 tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt ctcctacctt 26160 ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct caagggcgag 26220 gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac ctggcagacg 26280 gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct gcagaaactg 26340 ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt ggccgcgcac 26400 ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg tctgccagac 26460 ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg ctcaggaatc 26520 ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta ccgcgaatgc 26580 cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct tgcctaccac 26640 tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg tcgctgcaac 26700 ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga aagtcaaatt 26760 atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc tccggggttg 26820 aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc tgaggactac 26880 cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccaaatgc ggagcttacc 26940 gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa caaagcccgc 27000 caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc cggcgaggag 27060 ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc ccttgcttcc 27120 caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg aggaggaata 27180 ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga tggaagactg 27240 ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa caccgtcacc 27300 ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca gcatggctac 27360 aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc gtagatggga 27420 caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc aagagcaaca 27480 acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg cttgcttgca 27540 agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc acggcgtggc 27600 cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact gcaccggcgg 27660 cagcggcagc ggcagcaaca gcagcggcca cacagaagca aaggcgaccg gatagcaaga 27720 ctctgacaaa gcccaagaaa tccacagcgg cggcagcagc aggaggagga gcgctgcgtc 27780 tggcgcccaa cgaacccgta tcgacccgcg agcttagaaa caggattttt cccactctgt 27840 atgctatatt tcaacagagc aggggccaag aacaagagct gaaaataaaa aacaggtctc 27900 tgcgatccct cacccgcagc tgcctgtatc acaaaagcga agatcagctt cggcgcacgc 27960 tggaagacgc ggaggctctc ttcagtaaat actgcgcgct gactcttaag gactagtttc 28020 gcgccctttc tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca cacccggcgc 28080 cagcacctgt cgtcagcgcc atttcaactt tgtatacaaa agttgtgatg agcaaggaaa 28140 ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct ggagctgccc 28200 aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata tcccgggtca 28260 acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt accaccacac 28320 ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg 28380 ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg actaactcag 28440 gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag ggtataactc 28500 acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg 28560 gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca ttcacgcctc 28620 gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga ggcattggaa 28680 ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc tcgggacctc 28740 ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac tcggcggacg 28800 gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact 28860 gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt gaattgcccg 28920 aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga gagcttgccc 28980 gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac aggggaccct 29040 gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat ctttgttgcc 29100 atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc ctatcgccat 29160 cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt acctggtact 29220 tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt gagtctacga 29280 gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct tacctgccgg 29340 gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg taaaccagac 29400 tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc ttagaaaacc 29460 cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt caagcaactc 29520 tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc tctgtcttgt 29580 gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct gctgtgtgca 29640 catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat gattaggtac 29700 ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa ggtggatttt 29760 aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac cactcttata 29820 aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat tggcaagtat 29880 gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac agttttccag 29940 ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg cgacattacc 30000 atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga aaacactggc 30060 actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac cctactctat 30120 attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta atttactaag 30180 ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca aattcaaaaa 30240 gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct caataccatt 30300 cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg aagtcaggct 30360 tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt tccagtccaa 30420 ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc cgctaccgga 30480 cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg ggataacttg 30540 ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat gtggctcatc 30600 tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat tgtgctacac 30660 ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt ttctcttaca 30720 gtatgattaa atgagacatg attcctcgag tttttatatt actgaccctt gttgcgcttt 30780 tttgtgcgtg ctccacattg gctgcggttt ctcacatcga agtagactgc attccagcct 30840 tcacagtcta tttgctttac ggatttgtca ccctcacgct catctgcagc ctcatcactg 30900 tggtcatcgc ctttatccag tgcattgact gggtctgtgt gcgctttgca tatctcagac 30960 accatcccca gtacagggac aggactatag ctgagcttct tagaattctt taattatgaa 31020 atttactgtg acttttctgc tgattatttg caccctatct gcgttttgtt ccccgacctc 31080 caagcctcaa agacatatat catgcagatt cactcgtata tggaatattc caagttgcta 31140 caatgaaaaa agcgatcttt ccgaagcctg gttatatgca atcatctctg ttatggtgtt 31200 ctgcagtacc atcttagccc tagctatata tccctacctt gacattggct ggaacgcaat 31260 agatgccatg aaccacccaa ctttccccgc gcccgctatg cttccactgc aacaagttgt 31320 tgccggcggc tttgtcccag ccaatcagcc tcgcccacct tctcccaccc ccactgaaat 31380 cagctacttt aatctaacag gaggagatga ctgacaccct agatctagaa atggacggaa 31440 ttattacaga gcagcgcctg ctagaaagac gcagggcagc ggccgagcaa cagcgcatga 31500 atcaagagct ccaagacatg gttaacttgc accagtgcaa aaggggtatc ttttgtctgg 31560 taaagcaggc caaagtcacc tacgacagta ataccaccgg acaccgcctt agctacaagt 31620 tgccaaccaa gcgtcagaaa ttggtggtca tggtgggaga aaagcccatt accataactc 31680 agcactcggt agaaaccgaa ggctgcattc actcaccttg tcaaggacct gaggatctct 31740 gcacccttat taagaccctg tgcggtctca aagatcttat tccctttaac taataaaaaa 31800 aaataataaa gcatcactta cttaaaatca gttagcaaat ttctgtccag tttattcagc 31860 agcacctcct tgccctcctc ccagctctgg tattgcagct tcctcctggc tgcaaacttt 31920 ctccacaatc taaatggaat gtcagtttcc tcctgttcct gtccatccgc acccactatc 31980 ttcatgttgt tgcagatgaa gcgcgcaaga ccgtctgaag ataccttcaa ccccgtgtat 32040 ccatatgaca cggaaaccgg tcctccaact gtgccttttc ttactcctcc ctttgtatcc 32100 cccaatgggt ttcaagagag tccccctggg gtactctctt tgcgcctatc cgaacctcta 32160 gttacctcca atggcatgct tgcgctcaaa atgggcaacg gcctctctct ggacgaggcc 32220 ggcaacctta cctcccaaaa tgtaaccact gtgagcccac ctctcaaaaa aaccaagtca 32280 aacataaacc tggaaatatc tgcacccctc acagttacct cagaagccct aactgtggct 32340 gccgccgcac ctctaatggt cgcgggcaac acactcacca tgcaatcaca ggccccgcta 32400 accgtgcacg actccaaact tagcattgcc acccaaggac ccctcacagt gtcagaagga 32460 aagctagccc tgcaaacatc aggccccctc accaccaccg atagcagtac ccttactatc 32520 actgcctcac cccctctaac tactgccact ggtagcttgg gcattgactt gaaagagccc 32580 atttatacac aaaatggaaa actaggacta aagtacgggg ctcctttgca tgtaacagac 32640 gacctaaaca ctttgaccgt agcaactggt ccaggtgtga ctattaataa tacttccttg 32700 caaactaaag ttactggagc cttgggtttt gattcacaag gcaatatgca acttaatgta 32760 gcaggaggac taaggattga ttctcaaaac agacgcctta tacttgatgt tagttatccg 32820 tttgatgctc aaaaccaact aaatctaaga ctaggacagg gccctctttt tataaactca 32880 gcccacaact tggatattaa ctacaacaaa ggcctttact tgtttacagc ttcaaacaat 32940 tccaaaaagc ttgaggttaa cctaagcact gccaaggggt tgatgtttga cgctacagcc 33000 atagccatta atgcaggaga tgggcttgaa tttggttcac ctaatgcacc aaacacaaat 33060 cccctcaaaa caaaaattgg ccatggccta gaatttgatt caaacaaggc tatggttcct 33120 aaactaggaa ctggccttag ttttgacagc acaggtgcca ttacagtagg aaacaaaaat 33180 aatgataagc taactttatg gacaactcca gacacatctc caaattgcaa gattgatcaa 33240 gataaggact ctaagttaac tctggtcctt acaaagtgtg gaagtcaaat attggctaat 33300 gtgtcattaa ttgtcgtagc tggtaagtac aaaattatca ataacaatac tcaaccagct 33360 ctcaaaggat ttaccattaa attattgttt gatgaaaatg gagtacttat ggaatcttca 33420 aatcttggta aatcatattg gaactttaga aatgaaaatt caattatgtc aacagcttat 33480 gaaaaagcta ttggattcat gcctaatttg gtagcctatc caaaacctac cgctggctct 33540 aaaaaatatg caagagatat agtttatgga aacatctacc ttggtggaaa gccagatcaa 33600 ccagtaacca ttaaaactac ctttaatcag gaaactggat gtgaatattc tatcacattt 33660 gattttagtt gggccaagac ttatgtaaat gttgaatttg aaacaacctc ttttaccttt 33720 tcctatatcg cccaagaata ataaagaatc gtttgtgtta tgtttcaacg tgtttatttt 33780 tcaattgcag aaaatttcaa gtcatttttc attcagtagt atagccccac caccacatag 33840 cttatacaga tcaccgtacc tcaactttgt ataataaagt tgtaatcaaa ctcacagaac 33900 cctagtattc aacctgccac ctccctccca acacacagag tacacagtcc tttctccccg 33960 gctggcctta aaaagcatca tatcatgggt aacagacata ttcttaggtg ttatattcca 34020 cacggtttcc tgtcgagcca aacgctcatc agtgatatta ataaactccc cgggcagctc 34080 acttaagttc atgtcgctgt ccagctgctg agccacaggc tgctgtccaa cttgcggttg 34140 cttaacgggc ggcgaaggag aagtccacgc ctacatgggg gtagagtcat aatcgtgcat 34200 caggataggg cggtggtgct gcagcagcgc gcgaataaac tgctgccgcc gccgctccgt 34260 cctgcaggaa tacaacatgg cagtggtctc ctcagcgatg attcgcaccg cccgcagcat 34320 aaggcgcctt gtcctccggg cacagcagcg caccctgatc tcacttaaat cagcacagta 34380 actgcagcac agcaccacaa tattgttcaa aatcccacag tgcaaggcgc tgtatccaaa 34440 gctcatggcg gggaccacag aacccacgtg gccatcatac cacaagcgca ggtagattaa 34500 gtggcgaccc ctcataaaca cgctggacat aaacattacc tcttttggca tgttgtaatt 34560 caccacctcc cggtaccata taaacctctg attaaacatg gcgccatcca ccaccatcct 34620 aaaccagctg gccaaaacct gcccgccggc tatacactgc agggaaccgg gactggaaca 34680 atgacagtgg agagcccagg actcgtaacc atggatcatc atgctcgtca tgatatcaat 34740 gttggcacaa cacaggcaca cgtgcataca cttcctcagg attacaagct cctcccgcgt 34800 tagaaccata tcccagggaa caacccattc ctgaatcagc gtaaatccca cactgcaggg 34860 aagacctcgc acgtaactca cgttgtgcat tgtcaaagtg ttacattcgg gcagcagcgg 34920 atgatcctcc agtatggtag cgcgggtttc tgtctcaaaa ggaggtagac gatccctact 34980 gtacggagtg cgccgagaca accgagatcg tgttggtcgt agtgtcatgc caaatggaac 35040 gccggacgta gtcatatttc ctgaagcaaa accaggtgcg ggcgtgacaa acagatctgc 35100 gtctccggtc tcgccgctta gatcgctctg tgtagtagtt gtagtatatc cactctctca 35160 aagcatccag gcgccccctg gcttcgggtt ctatgtaaac tccttcatgc gccgctgccc 35220 tgataacatc caccaccgca gaataagcca cacccagcca acctacacat tcgttctgcg 35280 agtcacacac gggaggagcg ggaagagctg gaagaaccat gttttttttt ttattccaaa 35340 agattatcca aaacctcaaa atgaagatct attaagtgaa cgcgctcccc tccggtggcg 35400 tggtcaaact ctacagccaa agaacagata atggcatttg taagatgttg cacaatggct 35460 tccaaaaggc aaacggccct cacgtccaag tggacgtaaa ggctaaaccc ttcagggtga 35520 atctcctcta taaacattcc agcaccttca accatgccca aataattctc atctcgccac 35580 cttctcaata tatctctaag caaatcccga atattaagtc cggccattgt aaaaatctgc 35640 tccagagcgc cctccacctt cagcctcaag cagcgaatca tgattgcaaa aattcaggtt 35700 cctcacagac ctgtataaga ttcaaaagcg gaacattaac aaaaataccg cgatcccgta 35760 ggtcccttcg cagggccagc tgaacataat cgtgcaggtc tgcacggacc agcgcggcca 35820 cttccccgcc aggaaccatg acaaaagaac ccacactgat tatgacacgc atactcggag 35880 ctatgctaac cagcgtagcc ccgatgtaag cttgttgcat gggcggcgat ataaaatgca 35940 aggtgctgct caaaaaatca ggcaaagcct cgcgcaaaaa agaaagcaca tcgtagtcat 36000 gctcatgcag ataaaggcag gtaagctccg gaaccaccac agaaaaagac accatttttc 36060 tctcaaacat gtctgcgggt ttctgcataa acacaaaata aaataacaaa aaaacattta 36120 aacattagaa gcctgtctta caacaggaaa aacaaccctt ataagcataa gacggactac 36180 ggccatgccg gcgtgaccgt aaaaaaactg gtcaccgtga ttaaaaagca ccaccgacag 36240 ctcctcggtc atgtccggag tcataatgta agactcggta aacacatcag gttgattcac 36300 atcggtcagt gctaaaaagc gaccgaaata gcccggggga atacataccc gcaggcgtag 36360 agacaacatt acagccccca taggaggtat aacaaaatta ataggagaga aaaacacata 36420 aacacctgaa aaaccctcct gcctaggcaa aatagcaccc tcccgctcca gaacaacata 36480 cagcgcttcc acagcggcag ccataacagt cagccttacc agtaaaaaag aaaacctatt 36540 aaaaaaacac cactcgacac ggcaccagct caatcagtca cagtgtaaaa aagggccaag 36600 tgcagagcga gtatatatag gactaaaaaa tgacgtaacg gttaaagtcc acaaaaaaca 36660 cccagaaaac cgcacgcgaa cctacgccca gaaacgaaag ccaaaaaacc cacaacttcc 36720 tcaaatcgtc acttccgttt tcccacgtta cgtcacttcc cattttaaga aaactacaat 36780 tcccaacaca tacaagttac tccgccctaa aacctacgtc acccgccccg ttcccacgcc 36840 ccgcgccacg tcacaaactc caccccctca ttatcatatt ggcttcaatc caaaataagg 36900 tatattattg atgatg 36916 <210> 71 <211> 36949 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO174) <400> 71 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattaaac cgtattaccg ccatgcattt aatggagtgc 480 ctcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa 540 gttgggggga ggggtcggca attgaaccgg tgcctagaga aggtggcgcg gggtaaactg 600 ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat 660 aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacaggt 720 aagtgccgtg tgtggttccc gcgggcctgg cctctttacg ggttatggcc cttgcgtgcc 780 ttgaattact tccacctggc tgcagtacgt gattcttgat cccgagcttc gggttggaag 840 tgggtgggag agttcgaggc cttgcgctta aggagcccct tcgcctcgtg cttgagttga 900 ggcctggcct gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct 960 cgctgctttc gataagtctc tagccattta aaatttttga tgacctgctg cgacgctttt 1020 tttctggcaa gatagtcttg taaatgcggg ccaagatctg cacactggta tttcggtttt 1080 tggggccgcg ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg 1140 cctgcgagcg cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct 1200 ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc 1260 ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag ggagctcaaa 1320 atggaggacg cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc 1380 ctttccgtcc tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca 1440 cctcgattag ttctcgagct tttggagtac gtcgtcttta ggttgggggg aggggtttta 1500 tgcgatggag tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt 1560 gatgtaattc tccttggaat ttgccctttt tgagtttgga tcttggttca ttctcaagcc 1620 tcagacagtg gttcaaagtt tttttcttcc atttcaggtg tcgtgacgct agcgctaccg 1680 gactcagatc tcgagctcaa gcttcgaatt ctgcagtcga cggtaccgga tccatggaag 1740 acgccaaaaa cataaagaaa ggcccggcgc cattctatcc gctggaagat ggaaccgctg 1800 gagagcaact gcataaggct atgaagagat acgccctggt tcctggaaca attgctttta 1860 cagatgcaca tatcgaggtg gacatcactt acgctgagta cttcgaaatg tccgttcggt 1920 tggcagaagc tatgaaacga tatgggctga atacaaatca cagaatcgtc gtatgcagtg 1980 aaaactctct tcaattcttt atgccggtgt tgggcgcgtt atttatcgga gttgcagttg 2040 cgcccgcgaa cgacatttat aatgaacgtg aattgctcaa cagtatgggc atttcgcagc 2100 ctaccgtggt gttcgtttcc aaaaaggggt tgcaaaaaat tttgaacgtg caaaaaaagc 2160 tcccaatcat ccaaaaaatt attatcatgg attctaaaac ggattaccag ggatttcagt 2220 cgatgtacac gttcgtcaca tctcatctac ctcccggttt taatgaatac gattttgtgc 2280 cagagtcctt cgatagggac aagacaattg cactgatcat gaactcctct ggatctactg 2340 gtctgcctaa aggtgtcgct ctgcctcata gaactgcctg cgtgagattc tcgcatgcca 2400 gagatcctat ttttggcaat caaatcattc cggatactgc gattttaagt gttgttccat 2460 tccatcacgg ttttggaatg tttactacac tcggatattt gatatgtgga tttcgagtcg 2520 tcttaatgta tagatttgaa gaagagctgt ttctgaggag ccttcaggat tacaagattc 2580 aaagtgcgct gctggtgcca accctattct ccttcttcgc caaaagcact ctgattgaca 2640 aatacgattt atctaattta cacgaaattg cttctggtgg cgctcccctc tctaaggaag 2700 tcggggaagc ggttgccaag aggttccatc tgccaggtat caggcaagga tatgggctca 2760 ctgagactac atcagctatt ctgattacac ccgaggggga tgataaaccg ggcgcggtcg 2820 gtaaagttgt tccatttttt gaagcgaagg ttgtggatct ggataccggg aaaacgctgg 2880 gcgttaatca aagaggcgaa ctgtgtgtga gaggtcctat gattatgtcc ggttatgtaa 2940 acaatccgga agcgaccaac gccttgattg acaaggatgg atggctacat tctggagaca 3000 tagcttactg ggacgaagac gaacacttct tcatcgttga ccgcctgaag tctctgatta 3060 agtacaaagg ctatcaggtg gctcccgctg aattggaatc catcttgctc caacacccca 3120 acatcttcga cgcaggtgtc gcaggtcttc ccgacgatga cgccggtgaa cttcccgccg 3180 ccgttgttgt tttggagcac ggaaagacga tgacggaaaa agagatcgtg gattacgtcg 3240 ccagtcaagt aacaaccgcg aaaaagttgc gcggaggagt tgtgtttgtg gacgaagtac 3300 cgaaaggtct taccggaaaa ctcgacgcaa gaaaaatcag agagatcctc ataaaggcca 3360 agaagggcgg aaagatcgcc gtggcagccg cagccaccat ggtgagcaag ggcgaggagc 3420 tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt 3480 tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca 3540 tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg 3600 gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg 3660 ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca 3720 agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg 3780 gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca 3840 gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga 3900 tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc 3960 ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc 4020 tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg 4080 ccgggatcac tctcggcatg gacgagctgt acaagtaaag cgactctaga tcataatcag 4140 ccatacccaa acaccattgt cacactccaa tcgattcaaa caccattgtc acactccaac 4200 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4260 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4320 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4380 tttgtccaaa ctcatcaatg taagtttaaa cggcgcgcct gaaatgtgtg ggcgtggctt 4440 aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct gttttgcagc 4500 agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct catatttgac 4560 aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca gcattgatgg 4620 tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt ctggaacgcc 4680 gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc gcgggattgt 4740 gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt catccgcccg 4800 cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg aacttaatgt 4860 cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg cttcctcccc 4920 tcccaatgcg gtttaaaaca caacttttct atacaaagtt gtaaataaaa aaccagactc 4980 tgtttggatt tggatcaagc taagtgtctt gctgtcttta tttaggggtt ttgcgcgcgc 5040 ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct gtgtattttt tccaggacgt 5100 ggtaaaggtg actctggatg ttcagataca tgggcataag cccgtctctg gggtggaggt 5160 agcaccactg cagagcttca tgctgcgggg tggtgttgta gatgatccag tcgtagcagg 5220 agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa gctgattgcc aggggcaggc 5280 ccttggtgta agtgtttaca aagcggttaa gctgggatgg gtgcatacgt ggggatatga 5340 gatgcatctt ggactgtatt tttaggttgg ctatgttccc agccatatcc ctccggggat 5400 tcatgttgtg cagaaccacc agcacagtgt atccggtgca cttgggaaat ttgtcatgta 5460 gcttagaagg aaatgcgtgg aagaacttgg agacgccctt gtgacctcca agattttcca 5520 tgcattcgtc cataatgatg gcaatgggcc cacgggcggc ggcctgggcg aagatatttc 5580 tgggatcact aacgtcatag ttgtgttcca ggatgagatc gtcataggcc atttttacaa 5640 agcgcgggcg gagggtgcca gactgcggta taatggttcc atccggccca ggggcgtagt 5700 taccctcaca gatttgcatt tcccacgctt tgagttcaga tggggggatc atgtctacct 5760 gcggggcgat gaagaaaacg gtttccgggg taggggagat cagctgggaa gaaagcaggt 5820 tcctgagcag ctgcgactta ccgcagccgg tgggcccgta aatcacacct attaccggct 5880 gcaactggta gttaagagag ctgcagctgc cgtcatccct gagcaggggg gccacttcgt 5940 taagcatgtc cctgactcgc atgttttccc tgaccaaatc cgccagaagg cgctcgccgc 6000 ccagcgatag cagttcttgc aaggaagcaa agtttttcaa cggtttgaga ccgtccgccg 6060 taggcatgct tttgagcgtt tgaccaagca gttccaggcg gtcccacagc tcggtcacct 6120 gctctacggc atctcgatcc agcatatctc ctcgtttcgc gggttggggc ggctttcgct 6180 gtacggcagt agtcggtgct cgtccagacg ggccagggtc atgtctttcc acgggcgcag 6240 ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc gctccgggct gcgcgctggc 6300 cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc tgccggtctt cgccctgcgc 6360 gtcggccagg tagcatttga ccatggtgtc atagtccagc ccctccgcgg cgtggccctt 6420 ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg cagtgcagac ttttgagggc 6480 gtagagcttg ggcgcgagaa ataccgattc cggggagtag gcatccgcgc cgcaggcccc 6540 gcagacggtc tcgcattcca cgagccaggt gagctctggc cgttcggggt caaaaaccag 6600 gtttccccca tgctttttga tgcgtttctt acctctggtt tccatgagcc ggtgtccacg 6660 ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac ttgagaggcc tgtcctcgag 6720 cggtgttccg cggtcctcct cgtatagaaa ctcggaccac tctgagacaa aggctcgcgt 6780 ccaggccagc acgaaggagg ctaagtggga ggggtagcgg tcgttgtcca ctagggggtc 6840 cactcgctcc agggtgtgaa gacacatgtc gccctcttcg gcatcaagga aggtgattgg 6900 tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg gggctataaa agggggtggg 6960 ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg agggccagct gttggggtga 7020 gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga ttgtcagttt ccaaaaacga 7080 ggaggatttg atattcacct ggcccgcggt gatgcctttg agggtggccg catccatctg 7140 gtcagaaaag acaatctttt tgttgtcaag cttggtggca aacgacccgt agagggcgtt 7200 ggacagcaac ttggcgatgg agcgcagggt ttggtttttg tcgcgatcgg cgcgctcctt 7260 ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac cgccattcgg gaaagacggt 7320 ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg ttgtgcaggg tgacaaggtc 7380 aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc cagcagaggc ggccgccctt 7440 gcgcgagcag aatggcggta gggggtctag ctgcgtctcg tccggggggt ctgcgtccac 7500 ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct atcttgcatc cttgcaagtc 7560 tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg tatgggttga gtgggggacc 7620 ccatggcatg gggtgggtga gcgcggaggc gtacatgccg caaatgtcgt aaacgtagag 7680 gggctctctg agtattccaa gatatgtagg gtagcatctt ccaccgcgga tgctggcgcg 7740 cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg ggaccgaggt tgctacgggc 7800 gggctgctct gctcggaaga ctatctgcct gaagatggca tgtgagttgg atgatatggt 7860 tggacgctgg aagacgttga agctggcgtc tgtgagacct accgcgtcac gcacgaagga 7920 ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg acctgcacgt ctagggcgca 7980 gtagtccagg gtttccttga tgatgtcata cttatcctgt cccttttttt tccacagctc 8040 gcggttgagg acaaactctt cgcggtcttt ccagtactct tggatcggaa acccgtcggc 8100 ctccgaacgg taagagccta gcatgtagaa ctggttgacg gcctggtagg cgcagcatcc 8160 cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg agcgaggtgt gggtgagcgc 8220 aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg aagtcagtgt cgtcgcatcc 8280 gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa cgcggatttg gcagggcgaa 8340 ggtgacatcg ttgaagagta tctttcccgc gcgaggcata aagttgcgtg tgatgcggaa 8400 gggtcccggc acctcggaac ggttgttaat tacctgggcg gcgagcacga tctcgtcaaa 8460 gccgttgatg ttgtggccca caatgtaaag ttccaagaag cgcgggatgc ccttgatgga 8520 aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg gagctgagcc cgtgctctga 8580 aagggcccag tctgcaagat gagggttgga agcgacgaat gagctccaca ggtcacgggc 8640 cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg cgacctatgg ccattttttc 8700 tggggtgatg cagtagaagg taagcgggtc ttgttcccag cggtcccatc caaggttcgc 8760 ggctaggtct cgcgcggcag tcactagagg ctcatctccg ccgaacttca tgaccagcat 8820 gaagggcacg agctgcttcc caaaggcccc catccaagta taggtctcta catcgtaggt 8880 gacaaagaga cgctcggtgc gaggatgcga gccgatcggg aagaactgga tctcccgcca 8940 ccaattggag gagtggctat tgatgtggtg aaagtagaag tccctgcgac gggccgaaca 9000 ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag cggtgcacgg gctgtacatc 9060 ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag agtgggaatt tgagcccctc 9120 gcctggcggg tttggctggt ggtcttctac ttcggctgct tgtccttgac cgtctggctg 9180 ctcgagggga gttacggtgg atcggaccac cacgccgcgc gagcccaaag tccagatgtc 9240 cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga tgggagctgt ccatggtctg 9300 gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg tttacctcgc atagacgggt 9360 cagggcgcgg gctagatcca ggtgatacct aatttccagg ggctggttgg tggcggcgtc 9420 gatggcttgc aagaggccgc atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg 9480 ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt gacgcgggcg agcccccgga 9540 ggtagggggg gctccggacc cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg 9600 ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc 9660 tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag 9720 agttcgacag aatcaatttc ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg 9780 tctcctgagt tgtcttgata ggcgatctcg gccatgaact gctcgatctc ttcctcctgg 9840 agatctccgc gtccggctcg ctccacggtg gcggcgaggt cgttggaaat gcgggccatg 9900 agctgcgaga aggcgttgag gcctccctcg ttccagacgc ggctgtagac cacgccccct 9960 tcggcatcgc gggcgcgcat gaccacctgc gcgagattga gctccacgtg ccgggcgaag 10020 acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc 10080 acgaagaagt acataaccca gcgtcgcaac gtggattcgt tgatatcccc caaggcctca 10140 aggcgctcca tggcctcgta gaagtccacg gcgaagttga aaaactggga gttgcgcgcc 10200 gacacggtta actcctcctc cagaagacgg atgagctcgg cgacagtgtc gcgcacctcg 10260 cgctcaaagg ctacaggggc ctcttcttct tcttcaatct cctcttccat aagggcctcc 10320 ccttcttctt cttctggcgg cggtggggga ggggggacac ggcggcgacg acggcgcacc 10380 gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc gacggcgcat ggtctcggtg 10440 acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc cgcccgtcat gtcccggtta 10500 tgggttggcg gggggctgcc atgcggcagg gatacggcgc taacgatgca tctcaacaat 10560 tgttgtgtag gtactccgcc gccgagggac ctgagcgagt ccgcatcgac cggatcggaa 10620 aacctctcga gaaaggcgtc taaccagtca cagtcgcaag gtaggctgag caccgtggcg 10680 ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg tgctgctgat gatgtaatta 10740 aagtaggcgg tcttgagacg gcggatggtc gacagaagca ccatgtcctt gggtccggcc 10800 tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt tttgacatcg gcgcaggtct 10860 ttgtagtagt cttgcatgag cctttctacc ggcacttctt cttctccttc ctcttgtcct 10920 gcatctcttg catctatcgc tgcggcggcg gcggagtttg gccgtaggtg gcgccctctt 10980 cctcccatgc gtgtgacccc gaagcccctc atcggctgaa gcagggctag gtcggcgaca 11040 acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg tagactggaa gtcatccatg 11100 tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag tgcagttggc cataacggac 11160 cagttaacgg tctggtgacc cggctgcgag agctcggtgt acctgagacg cgagtaagcc 11220 ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt actggtatcc caccaaaaag 11280 tgcggcggcg gctggcggta gaggggccag cgtagggtgg ccggggctcc gggggcgaga 11340 tcttccaaca taaggcgatg atatccgtag atgtacctgg acatccaggt gatgccggcg 11400 gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc agatgttgcg cagcggcaaa 11460 aagtgctcca tggtcgggac gctctggccg gtcaggcgcg cgcaatcgtt gacgctctag 11520 accgtgcaaa aggagagcct gtaagcgggc actcttccgt ggtctggtgg ataaattcgc 11580 aagggtatca tggcggacga ccggggttcg agccccgtat ccggccgtcc gccgtgatcc 11640 atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg tcagacaacg ggggagtgct 11700 ccttttggct tccttccagg cgcggcggct gctgcgctag cttttttggc cactggccgc 11760 gcgcagcgta agcggttagg ctggaaagcg aaagcattaa gtggctcgct ccctgtagcc 11820 ggagggttat tttccaaggg ttgagtcgcg ggacccccgg ttcgagtctc ggaccggccg 11880 gactgcggcg aacgggggtt tgcctccccg tcatgcaaga ccccgcttgc aaattcctcc 11940 ggaaacaggg acgagcccct tttttgcttt tcccagatgc atccggtgct gcggcagatg 12000 cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc agacatgcag ggcaccctcc 12060 cctcctccta ccgcgtcagg aggggcgaca tccgcggttg acgcggcagc agatggtgat 12120 tacgaacccc cgcggcgccg ggcccggcac tacctggact tggaggaggg cgagggcctg 12180 gcgcggctag gagcgccctc tcctgagcgg cacccaaggg tgcagctgaa gcgtgatacg 12240 cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc gcgagggaga ggagcccgag 12300 gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc ggcatggcct gaatcgcgag 12360 cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa ccgggattag tcccgcgcgc 12420 gcacacgtgg cggccgccga cctggtaacc gcatacgagc agacggtgaa ccaggagatt 12480 aactttcaaa aaagctttaa caaccacgtg cgtacgcttg tggcgcgcga ggaggtggct 12540 ataggactga tgcatctgtg ggactttgta agcgcgctgg agcaaaaccc aaatagcaag 12600 ccgctcatgg cgcagctgtt ccttatagtg cagcacagca gggacaacga ggcattcagg 12660 gatgcgctgc taaacatagt agagcccgag ggccgctggc tgctcgattt gataaacatc 12720 ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg ctgacaaggt ggccgccatc 12780 aactattcca tgcttagcct gggcaagttt tacgcccgca agatatacca taccccttac 12840 gttcccatag acaaggaggt aaagatcgag gggttctaca tgcgcatggc gctgaaggtg 12900 cttaccttga gcgacgacct gggcgtttat cgcaacgagc gcatccacaa ggccgtgagc 12960 gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc acagcctgca aagggccctg 13020 gctggcacgg gcagcggcga tagagaggcc gagtcctact ttgacgcggg cgctgacctg 13080 cgctgggccc caagccgacg cgccctggag gcagctgggg ccggacctgg gctggcggtg 13140 gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat atgacgagga cgatgagtac 13200 gagccagagg acggcgagta ctaagcggtg atgtttctga tcagatgatg caagacgcaa 13260 cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc cggccttaac tccacggacg 13320 actggcgcca ggtcatggac cgcatcatgt cgctgactgc gcgcaatcct gacgcgttcc 13380 ggcagcagcc gcaggccaac cggctctccg caattctgga agcggtggtc ccggcgcgcg 13440 caaaccccac gcacgagaag gtgctggcga tcgtaaacgc gctggccgaa aacagggcca 13500 tccggcccga cgaggccggc ctggtctacg acgcgctgct tcagcgcgtg gctcgttaca 13560 acagcggcaa cgtgcagacc aacctggacc ggctggtggg ggatgtgcgc gaggccgtgg 13620 cgcagcgtga gcgcgcgcag cagcagggca acctgggctc catggttgca ctaaacgcct 13680 tcctgagtac acagcccgcc aacgtgccgc ggggacagga ggactacacc aactttgtga 13740 gcgcactgcg gctaatggtg actgagacac cgcaaagtga ggtgtaccag tctgggccag 13800 actatttttt ccagaccagt agacaaggcc tgcagaccgt aaacctgagc caggctttca 13860 aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg cgaccgcgcg accgtgtcta 13920 gcttgctgac gcccaactcg cgcctgttgc tgctgctaat agcgcccttc acggacagtg 13980 gcagcgtgtc ccgggacaca tacctaggtc acttgctgac actgtaccgc gaggccatag 14040 gtcaggcgca tgtggacgag catactttcc aggagattac aagtgtcagc cgcgcgctgg 14100 ggcaggagga cacgggcagc ctggaggcaa ccctaaacta cctgctgacc aaccggcggc 14160 agaagatccc ctcgttgcac agtttaaaca gcgaggagga gcgcattttg cgctacgtgc 14220 agcagagcgt gagccttaac ctgatgcgcg acggggtaac gcccagcgtg gcgctggaca 14280 tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa ccggccgttt atcaaccgcc 14340 taatggacta cttgcatcgc gcggccgccg tgaaccccga gtatttcacc aatgccatct 14400 tgaacccgca ctggctaccg ccccctggtt tctacaccgg gggattcgag gtgcccgagg 14460 gtaacgatgg attcctctgg gacgacatag acgacagcgt gttttccccg caaccgcaga 14520 ccctgctaga gttgcaacag cgcgagcagg cagaggcggc gctgcgaaag gaaagcttcc 14580 gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc gcggtcagat gctagtagcc 14640 catttccaag cttgataggg tctcttacca gcactcgcac cacccgcccg cgcctgctgg 14700 gcgaggagga gtacctaaac aactcgctgc tgcagccgca gcgcgaaaaa aacctgcctc 14760 cggcatttcc caacaacggg atagagagcc tagtggacaa gatgagtaga tggaagacgt 14820 acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc cacccgtcgt caaaggcacg 14880 accgtcagcg gggtctggtg tgggaggacg atgactcggc agacgacagc agcgtcctgg 14940 atttgggagg gagtggcaac ccgtttgcgc accttcgccc caggctgggg agaatgtttt 15000 aaaaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg gcaccgagcg 15060 ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg aaggtcctcc 15120 tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg gttctccctt 15180 cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta ccggggggag 15240 aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg tgtacctggt 15300 ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca gcaactttct 15360 gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac agaccatcaa 15420 tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata ccaacatgcc 15480 aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg tgtcgcgctt 15540 gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca cgctgcccga 15600 gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg tggagcacta 15660 cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa agtttgacac 15720 ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg gggtatatac 15780 aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg acttcaccca 15840 cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg agggctttag 15900 gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg tggacgccta 15960 ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg gcagcaacag 16020 cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc agccggtgga 16080 ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg aggagaagcg 16140 cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg aggtcgagaa 16200 gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac gcagttacaa 16260 cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg catacaacta 16320 cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg acgtaacctg 16380 cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg tgaccttccg 16440 ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc ccgtgcactc 16500 caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt ttacctctct 16560 gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc cagcccccac 16620 catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc taccgctgcg 16680 caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc gcacctgccc 16740 ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc gcactttttg 16800 agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc tgcgcttccc 16860 aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc gcgtgcgcgg 16920 gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca ccaccgtcga 16980 tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc cgccaccagt 17040 gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct atgctaaaat 17100 gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca ctgccgccca 17160 acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg cggccatgcg 17220 ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca ggcgacgagc 17280 ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg gcaacgtgta 17340 ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc ccccgcgcaa 17400 ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag cggcggcggc 17460 gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg tcatcgcgcc 17520 ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa agctaaagcg 17580 ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg aactgctgca 17640 cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac gtgttttgcg 17700 acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct acaagcgcgt 17760 gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc gcctcgggga 17820 gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg agggcaaccc 17880 aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg caccgtccga 17940 agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc agctgatggt 18000 acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac ctgggctgga 18060 gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg tgcagaccgt 18120 ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag agggcatgga 18180 gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg cggtcgctgc 18240 ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc gcgtttcagc 18300 cccccggcgc ccgcgccgtt cgaggaagta cggcgccgcc agcgcgctac tgcccgaata 18360 tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct accgccccag 18420 aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc gtcgccgtcg 18480 ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag gcaggaccct 18540 ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct ttgtggttct 18600 tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc gaggaagaat 18660 gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc gtgcgcacca 18720 ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc tccttattcc 18780 actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct tgcaggcgca 18840 gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt ctggactctc 18900 acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt gcgtctctgg 18960 ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc accagcaata 19020 tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat ttcggttcca 19080 ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg ctgagggata 19140 agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct ggcattagcg 19200 gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag cttgatcccc 19260 gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag gggcgtggcg 19320 aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac gagcctccct 19380 cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg cccatggcta 19440 ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc gccgacaccc 19500 agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct agccgcgcgt 19560 ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt ggcaactggc 19620 aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc cgacgatgct 19680 tctgaatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc gccagaggag 19740 ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga tgccgcagtg 19800 gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg ggctggtgca 19860 gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa accccacggt 19920 ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc ggttcatccc 19980 tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag ctgtgggtga 20040 taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc tggacagggg 20100 ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca agggtgcccc 20160 aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag aagaagagga 20220 cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc acgtatttgg 20280 gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag gtgtcgaagg 20340 tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag gagaatctca 20400 gtggtacgaa actgaaatta atcatgcagc tgggagagtc cttaaaaaga ctaccccaat 20460 gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc aaggcattct 20520 tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt tctcaactac 20580 tgaggcgacc gcaggcaatg gtgataactt gactcctaaa gtggtattgt acagtgaaga 20640 tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta aggaaggtaa 20700 ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca ttgcttttag 20760 ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg ttctggcggg 20820 ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag agctttcata 20880 ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt ggaatcaggc 20940 tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg aagatgaact 21000 tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta ccaaggtaaa 21060 acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt cagataaaaa 21120 tcaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca acctgtggag 21180 aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt acagtccttc 21240 caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc gagtggtggc 21300 tcccgggtta gtggactgct acattaacct tggagcacgc tggtcccttg actatatgga 21360 caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct caatgttgct 21420 gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct ttgccattaa 21480 aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga aggatgttaa 21540 catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca gcattaagtt 21600 tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg cctccacgct 21660 tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc tctccgccgc 21720 caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca tcccctcccg 21780 caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg aaaccccatc 21840 actgggctcg ggctacgacc cttattacac ctactctggc tctataccct acctagatgg 21900 aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact cttctgtcag 21960 ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc gctcagttga 22020 cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc tggtacaaat 22080 gctagctaac tacaacattg gctaccaggg cttctatatc ccagagagct acaaggaccg 22140 catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg atgatactaa 22200 atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg gatttgttgg 22260 ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc cctatccgct 22320 tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg atcgcaccct 22380 ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag acctgggcca 22440 aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg tggatcccat 22500 ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc gtgtgcaccg 22560 gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg ccggcaacgc 22620 cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc cagtgagcag 22680 gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg cacctatgac 22740 aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt caatacggcc 22800 ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca ctcaaaaaca 22860 tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt ttaccagttt 22920 gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg ctgtataacg 22980 ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg actattctgc 23040 tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca caaccccacc 23100 atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt acagcccacc 23160 ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc ctacttccgc 23220 agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa catgtaaaaa 23280 taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac tctcgggtga 23340 ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt ctgccgcgca 23400 tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct ccacttaaac 23460 tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct gcgcaccatc 23520 accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg gcctccgccc 23580 tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag cgccgggtgg 23640 tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc ctccgcgttg 23700 ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc gtgcccaggc 23760 tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt ctgggcgtta 23820 ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc ctttgcgcct 23880 tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca ggccgcgtcg 23940 tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc ccaccggttc 24000 ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt ttcgctcgtc 24060 acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag acacttaagc 24120 tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg ctcgtgatgc 24180 ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc catcatcgtc 24240 acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc gttcagccag 24300 gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa gttcgccttt 24360 agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat gcccttctcc 24420 cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact ttccgcttcg 24480 ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc gtcttcattc 24540 agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg tgggttgctg 24600 aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac gattacctct 24660 ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt gggcgcaatg 24720 gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac cagcgcgtct 24780 tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt ttttgggggc 24840 gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt tgggggacgt 24900 cgcgccgcac cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc ccgactggcc 24960 atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa ggacagccta 25020 accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc gcctaccacc 25080 ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca ggacccaggt 25140 tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa gcaagaccag 25200 gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca tggcgactac 25260 ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc cattatctgc 25320 gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag ccttgcctac 25380 gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg cacatgcgag 25440 cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct tgccacctat 25500 cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg cagccgagcg 25560 gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc gctcaacgaa 25620 gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa cgctctgcaa 25680 caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga gggtgacaac 25740 gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta cccggcactt 25800 aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg ccgtgcgcag 25860 cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc cgcagttggc 25920 gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga ggagcgacgc 25980 aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca gcggttcttt 26040 gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt tcgacagggc 26100 tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt ctcctacctt 26160 ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct caagggcgag 26220 gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac ctggcagacg 26280 gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct gcagaaactg 26340 ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt ggccgcgcac 26400 ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg tctgccagac 26460 ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg ctcaggaatc 26520 ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta ccgcgaatgc 26580 cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct tgcctaccac 26640 tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg tcgctgcaac 26700 ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga aagtcaaatt 26760 atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc tccggggttg 26820 aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc tgaggactac 26880 cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccaaatgc ggagcttacc 26940 gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa caaagcccgc 27000 caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc cggcgaggag 27060 ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc ccttgcttcc 27120 caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg aggaggaata 27180 ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga tggaagactg 27240 ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa caccgtcacc 27300 ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca gcatggctac 27360 aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc gtagatggga 27420 caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc aagagcaaca 27480 acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg cttgcttgca 27540 agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc acggcgtggc 27600 cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact gcaccggcgg 27660 cagcggcagc ggcagcaaca gcagcggcca cacagaagca aaggcgaccg gatagcaaga 27720 ctctgacaaa gcccaagaaa tccacagcgg cggcagcagc aggaggagga gcgctgcgtc 27780 tggcgcccaa cgaacccgta tcgacccgcg agcttagaaa caggattttt cccactctgt 27840 atgctatatt tcaacagagc aggggccaag aacaagagct gaaaataaaa aacaggtctc 27900 tgcgatccct cacccgcagc tgcctgtatc acaaaagcga agatcagctt cggcgcacgc 27960 tggaagacgc ggaggctctc ttcagtaaat actgcgcgct gactcttaag gactagtttc 28020 gcgccctttc tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca cacccggcgc 28080 cagcacctgt cgtcagcgcc atttcaactt tgtatacaaa agttgtgatg agcaaggaaa 28140 ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct ggagctgccc 28200 aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata tcccgggtca 28260 acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt accaccacac 28320 ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg 28380 ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg actaactcag 28440 gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag ggtataactc 28500 acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg 28560 gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca ttcacgcctc 28620 gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga ggcattggaa 28680 ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc tcgggacctc 28740 ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac tcggcggacg 28800 gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact 28860 gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt gaattgcccg 28920 aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga gagcttgccc 28980 gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac aggggaccct 29040 gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat ctttgttgcc 29100 atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc ctatcgccat 29160 cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt acctggtact 29220 tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt gagtctacga 29280 gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct tacctgccgg 29340 gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg taaaccagac 29400 tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc ttagaaaacc 29460 cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt caagcaactc 29520 tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc tctgtcttgt 29580 gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct gctgtgtgca 29640 catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat gattaggtac 29700 ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa ggtggatttt 29760 aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac cactcttata 29820 aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat tggcaagtat 29880 gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac agttttccag 29940 ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg cgacattacc 30000 atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga aaacactggc 30060 actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac cctactctat 30120 attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta atttactaag 30180 ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca aattcaaaaa 30240 gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct caataccatt 30300 cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg aagtcaggct 30360 tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt tccagtccaa 30420 ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc cgctaccgga 30480 cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg ggataacttg 30540 ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat gtggctcatc 30600 tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat tgtgctacac 30660 ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt ttctcttaca 30720 gtatgattaa atgagacatg attcctcgag tttttatatt actgaccctt gttgcgcttt 30780 tttgtgcgtg ctccacattg gctgcggttt ctcacatcga agtagactgc attccagcct 30840 tcacagtcta tttgctttac ggatttgtca ccctcacgct catctgcagc ctcatcactg 30900 tggtcatcgc ctttatccag tgcattgact gggtctgtgt gcgctttgca tatctcagac 30960 accatcccca gtacagggac aggactatag ctgagcttct tagaattctt taattatgaa 31020 atttactgtg acttttctgc tgattatttg caccctatct gcgttttgtt ccccgacctc 31080 caagcctcaa agacatatat catgcagatt cactcgtata tggaatattc caagttgcta 31140 caatgaaaaa agcgatcttt ccgaagcctg gttatatgca atcatctctg ttatggtgtt 31200 ctgcagtacc atcttagccc tagctatata tccctacctt gacattggct ggaacgcaat 31260 agatgccatg aaccacccaa ctttccccgc gcccgctatg cttccactgc aacaagttgt 31320 tgccggcggc tttgtcccag ccaatcagcc tcgcccacct tctcccaccc ccactgaaat 31380 cagctacttt aatctaacag gaggagatga ctgacaccct agatctagaa atggacggaa 31440 ttattacaga gcagcgcctg ctagaaagac gcagggcagc ggccgagcaa cagcgcatga 31500 atcaagagct ccaagacatg gttaacttgc accagtgcaa aaggggtatc ttttgtctgg 31560 taaagcaggc caaagtcacc tacgacagta ataccaccgg acaccgcctt agctacaagt 31620 tgccaaccaa gcgtcagaaa ttggtggtca tggtgggaga aaagcccatt accataactc 31680 agcactcggt agaaaccgaa ggctgcattc actcaccttg tcaaggacct gaggatctct 31740 gcacccttat taagaccctg tgcggtctca aagatcttat tccctttaac taataaaaaa 31800 aaataataaa gcatcactta cttaaaatca gttagcaaat ttctgtccag tttattcagc 31860 agcacctcct tgccctcctc ccagctctgg tattgcagct tcctcctggc tgcaaacttt 31920 ctccacaatc taaatggaat gtcagtttcc tcctgttcct gtccatccgc acccactatc 31980 ttcatgttgt tgcagatgaa gcgcgcaaga ccgtctgaag ataccttcaa ccccgtgtat 32040 ccatatgaca cggaaaccgg tcctccaact gtgccttttc ttactcctcc ctttgtatcc 32100 cccaatgggt ttcaagagag tccccctggg gtactctctt tgcgcctatc cgaacctcta 32160 gttacctcca atggcatgct tgcgctcaaa atgggcaacg gcctctctct ggacgaggcc 32220 ggcaacctta cctcccaaaa tgtaaccact gtgagcccac ctctcaaaaa aaccaagtca 32280 aacataaacc tggaaatatc tgcacccctc acagttacct cagaagccct aactgtggct 32340 gccgccgcac ctctaatggt cgcgggcaac acactcacca tgcaatcaca ggccccgcta 32400 accgtgcacg actccaaact tagcattgcc acccaaggac ccctcacagt gtcagaagga 32460 aagctagccc tgcaaacatc aggccccctc accaccaccg atagcagtac ccttactatc 32520 actgcctcac cccctctaac tactgccact ggtagcttgg gcattgactt gaaagagccc 32580 atttatacac aaaatggaaa actaggacta aagtacgggg ctcctttgca tgtaacagac 32640 gacctaaaca ctttgaccgt agcaactggt ccaggtgtga ctattaataa tacttccttg 32700 caaactaaag ttactggagc cttgggtttt gattcacaag gcaatatgca acttaatgta 32760 gcaggaggac taaggattga ttctcaaaac agacgcctta tacttgatgt tagttatccg 32820 tttgatgctc aaaaccaact aaatctaaga ctaggacagg gccctctttt tataaactca 32880 gcccacaact tggatattaa ctacaacaaa ggcctttact tgtttacagc ttcaaacaat 32940 tccaaaaagc ttgaggttaa cctaagcact gccaaggggt tgatgtttga cgctacagcc 33000 atagccatta atgcaggaga tgggcttgaa tttggttcac ctaatgcacc aaacacaaat 33060 cccctcaaaa caaaaattgg ccatggccta gaatttgatt caaacaaggc tatggttcct 33120 aaactaggaa ctggccttag ttttgacagc acaggtgcca ttacagtagg aaacaaaaat 33180 aatgataagc taactttatg gacaggagtc aaccccaccg aagccaactg tcaaatcatg 33240 aactccagtg aatctaatga ttgcaaatta attctaacac tagttaaaac tggagcacta 33300 gtcactgcat ttgtttatgt tataggagta tctaacaatt ttaatatgct aactacacac 33360 agaaatataa attttactgc agagctgttt ttcgattcta ctggtaattt actaactaga 33420 ctctcatccc tcaaaactcc acttaatcat aaatcaggac aaaacatggc tactggtgcc 33480 attactaatg ctaaaggttt catgcccagc acgactgcct atcctttcaa tgataattct 33540 agagaaaaag aaaactacat ttacggaact tgttactaca cagctagtga tcgcactgct 33600 tttcccattg acatatctgt catgcttaac cgaagagcaa taaatgacga gacatcatat 33660 tgtattcgta taacttggtc ctggaacaca ggagatgccc cagaggtgca aacctctgct 33720 acaaccctag tcacctcccc atttaccttt tactacatca gagaagacga ctaataaaga 33780 atcgtttgtg ttatgtttca acgtgtttat ttttcaattg cagaaaattt caagtcattt 33840 ttcattcagt agtatagccc caccaccaca tagcttatac agatcaccgt acctcaactt 33900 tgtataataa agttgtaatc aaactcacag aaccctagta ttcaacctgc cacctccctc 33960 ccaacacaca gagtacacag tcctttctcc ccggctggcc ttaaaaagca tcatatcatg 34020 ggtaacagac atattcttag gtgttatatt ccacacggtt tcctgtcgag ccaaacgctc 34080 atcagtgata ttaataaact ccccgggcag ctcacttaag ttcatgtcgc tgtccagctg 34140 ctgagccaca ggctgctgtc caacttgcgg ttgcttaacg ggcggcgaag gagaagtcca 34200 cgcctacatg ggggtagagt cataatcgtg catcaggata gggcggtggt gctgcagcag 34260 cgcgcgaata aactgctgcc gccgccgctc cgtcctgcag gaatacaaca tggcagtggt 34320 ctcctcagcg atgattcgca ccgcccgcag cataaggcgc cttgtcctcc gggcacagca 34380 gcgcaccctg atctcactta aatcagcaca gtaactgcag cacagcacca caatattgtt 34440 caaaatccca cagtgcaagg cgctgtatcc aaagctcatg gcggggacca cagaacccac 34500 gtggccatca taccacaagc gcaggtagat taagtggcga cccctcataa acacgctgga 34560 cataaacatt acctcttttg gcatgttgta attcaccacc tcccggtacc atataaacct 34620 ctgattaaac atggcgccat ccaccaccat cctaaaccag ctggccaaaa cctgcccgcc 34680 ggctatacac tgcagggaac cgggactgga acaatgacag tggagagccc aggactcgta 34740 accatggatc atcatgctcg tcatgatatc aatgttggca caacacaggc acacgtgcat 34800 acacttcctc aggattacaa gctcctcccg cgttagaacc atatcccagg gaacaaccca 34860 ttcctgaatc agcgtaaatc ccacactgca gggaagacct cgcacgtaac tcacgttgtg 34920 cattgtcaaa gtgttacatt cgggcagcag cggatgatcc tccagtatgg tagcgcgggt 34980 ttctgtctca aaaggaggta gacgatccct actgtacgga gtgcgccgag acaaccgaga 35040 tcgtgttggt cgtagtgtca tgccaaatgg aacgccggac gtagtcatat ttcctgaagc 35100 aaaaccaggt gcgggcgtga caaacagatc tgcgtctccg gtctcgccgc ttagatcgct 35160 ctgtgtagta gttgtagtat atccactctc tcaaagcatc caggcgcccc ctggcttcgg 35220 gttctatgta aactccttca tgcgccgctg ccctgataac atccaccacc gcagaataag 35280 ccacacccag ccaacctaca cattcgttct gcgagtcaca cacgggagga gcgggaagag 35340 ctggaagaac catgtttttt tttttattcc aaaagattat ccaaaacctc aaaatgaaga 35400 tctattaagt gaacgcgctc ccctccggtg gcgtggtcaa actctacagc caaagaacag 35460 ataatggcat ttgtaagatg ttgcacaatg gcttccaaaa ggcaaacggc cctcacgtcc 35520 aagtggacgt aaaggctaaa cccttcaggg tgaatctcct ctataaacat tccagcacct 35580 tcaaccatgc ccaaataatt ctcatctcgc caccttctca atatatctct aagcaaatcc 35640 cgaatattaa gtccggccat tgtaaaaatc tgctccagag cgccctccac cttcagcctc 35700 aagcagcgaa tcatgattgc aaaaattcag gttcctcaca gacctgtata agattcaaaa 35760 gcggaacatt aacaaaaata ccgcgatccc gtaggtccct tcgcagggcc agctgaacat 35820 aatcgtgcag gtctgcacgg accagcgcgg ccacttcccc gccaggaacc atgacaaaag 35880 aacccacact gattatgaca cgcatactcg gagctatgct aaccagcgta gccccgatgt 35940 aagcttgttg catgggcggc gatataaaat gcaaggtgct gctcaaaaaa tcaggcaaag 36000 cctcgcgcaa aaaagaaagc acatcgtagt catgctcatg cagataaagg caggtaagct 36060 ccggaaccac cacagaaaaa gacaccattt ttctctcaaa catgtctgcg ggtttctgca 36120 taaacacaaa ataaaataac aaaaaaacat ttaaacatta gaagcctgtc ttacaacagg 36180 aaaaacaacc cttataagca taagacggac tacggccatg ccggcgtgac cgtaaaaaaa 36240 ctggtcaccg tgattaaaaa gcaccaccga cagctcctcg gtcatgtccg gagtcataat 36300 gtaagactcg gtaaacacat caggttgatt cacatcggtc agtgctaaaa agcgaccgaa 36360 atagcccggg ggaatacata cccgcaggcg tagagacaac attacagccc ccataggagg 36420 tataacaaaa ttaataggag agaaaaacac ataaacacct gaaaaaccct cctgcctagg 36480 caaaatagca ccctcccgct ccagaacaac atacagcgct tccacagcgg cagccataac 36540 agtcagcctt accagtaaaa aagaaaacct attaaaaaaa caccactcga cacggcacca 36600 gctcaatcag tcacagtgta aaaaagggcc aagtgcagag cgagtatata taggactaaa 36660 aaatgacgta acggttaaag tccacaaaaa acacccagaa aaccgcacgc gaacctacgc 36720 ccagaaacga aagccaaaaa acccacaact tcctcaaatc gtcacttccg ttttcccacg 36780 ttacgtcact tcccatttta agaaaactac aattcccaac acatacaagt tactccgccc 36840 taaaacctac gtcacccgcc ccgttcccac gccccgcgcc acgtcacaaa ctccaccccc 36900 tcattatcat attggcttca atccaaaata aggtatatta ttgatgatg 36949 <210> 72 <211> 36907 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO175) <400> 72 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattaaac cgtattaccg ccatgcattt aatggagtgc 480 ctcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa 540 gttgggggga ggggtcggca attgaaccgg tgcctagaga aggtggcgcg gggtaaactg 600 ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat 660 aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacaggt 720 aagtgccgtg tgtggttccc gcgggcctgg cctctttacg ggttatggcc cttgcgtgcc 780 ttgaattact tccacctggc tgcagtacgt gattcttgat cccgagcttc gggttggaag 840 tgggtgggag agttcgaggc cttgcgctta aggagcccct tcgcctcgtg cttgagttga 900 ggcctggcct gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct 960 cgctgctttc gataagtctc tagccattta aaatttttga tgacctgctg cgacgctttt 1020 tttctggcaa gatagtcttg taaatgcggg ccaagatctg cacactggta tttcggtttt 1080 tggggccgcg ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg 1140 cctgcgagcg cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct 1200 ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc 1260 ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag ggagctcaaa 1320 atggaggacg cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc 1380 ctttccgtcc tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca 1440 cctcgattag ttctcgagct tttggagtac gtcgtcttta ggttgggggg aggggtttta 1500 tgcgatggag tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt 1560 gatgtaattc tccttggaat ttgccctttt tgagtttgga tcttggttca ttctcaagcc 1620 tcagacagtg gttcaaagtt tttttcttcc atttcaggtg tcgtgacgct agcgctaccg 1680 gactcagatc tcgagctcaa gcttcgaatt ctgcagtcga cggtaccgga tccatggaag 1740 acgccaaaaa cataaagaaa ggcccggcgc cattctatcc gctggaagat ggaaccgctg 1800 gagagcaact gcataaggct atgaagagat acgccctggt tcctggaaca attgctttta 1860 cagatgcaca tatcgaggtg gacatcactt acgctgagta cttcgaaatg tccgttcggt 1920 tggcagaagc tatgaaacga tatgggctga atacaaatca cagaatcgtc gtatgcagtg 1980 aaaactctct tcaattcttt atgccggtgt tgggcgcgtt atttatcgga gttgcagttg 2040 cgcccgcgaa cgacatttat aatgaacgtg aattgctcaa cagtatgggc atttcgcagc 2100 ctaccgtggt gttcgtttcc aaaaaggggt tgcaaaaaat tttgaacgtg caaaaaaagc 2160 tcccaatcat ccaaaaaatt attatcatgg attctaaaac ggattaccag ggatttcagt 2220 cgatgtacac gttcgtcaca tctcatctac ctcccggttt taatgaatac gattttgtgc 2280 cagagtcctt cgatagggac aagacaattg cactgatcat gaactcctct ggatctactg 2340 gtctgcctaa aggtgtcgct ctgcctcata gaactgcctg cgtgagattc tcgcatgcca 2400 gagatcctat ttttggcaat caaatcattc cggatactgc gattttaagt gttgttccat 2460 tccatcacgg ttttggaatg tttactacac tcggatattt gatatgtgga tttcgagtcg 2520 tcttaatgta tagatttgaa gaagagctgt ttctgaggag ccttcaggat tacaagattc 2580 aaagtgcgct gctggtgcca accctattct ccttcttcgc caaaagcact ctgattgaca 2640 aatacgattt atctaattta cacgaaattg cttctggtgg cgctcccctc tctaaggaag 2700 tcggggaagc ggttgccaag aggttccatc tgccaggtat caggcaagga tatgggctca 2760 ctgagactac atcagctatt ctgattacac ccgaggggga tgataaaccg ggcgcggtcg 2820 gtaaagttgt tccatttttt gaagcgaagg ttgtggatct ggataccggg aaaacgctgg 2880 gcgttaatca aagaggcgaa ctgtgtgtga gaggtcctat gattatgtcc ggttatgtaa 2940 acaatccgga agcgaccaac gccttgattg acaaggatgg atggctacat tctggagaca 3000 tagcttactg ggacgaagac gaacacttct tcatcgttga ccgcctgaag tctctgatta 3060 agtacaaagg ctatcaggtg gctcccgctg aattggaatc catcttgctc caacacccca 3120 acatcttcga cgcaggtgtc gcaggtcttc ccgacgatga cgccggtgaa cttcccgccg 3180 ccgttgttgt tttggagcac ggaaagacga tgacggaaaa agagatcgtg gattacgtcg 3240 ccagtcaagt aacaaccgcg aaaaagttgc gcggaggagt tgtgtttgtg gacgaagtac 3300 cgaaaggtct taccggaaaa ctcgacgcaa gaaaaatcag agagatcctc ataaaggcca 3360 agaagggcgg aaagatcgcc gtggcagccg cagccaccat ggtgagcaag ggcgaggagc 3420 tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt 3480 tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca 3540 tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg 3600 gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg 3660 ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca 3720 agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg 3780 gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca 3840 gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga 3900 tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc 3960 ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc 4020 tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg 4080 ccgggatcac tctcggcatg gacgagctgt acaagtaaag cgactctaga tcataatcag 4140 ccatacccaa acaccattgt cacactccaa tcgattcaaa caccattgtc acactccaac 4200 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4260 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4320 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4380 tttgtccaaa ctcatcaatg taagtttaaa cggcgcgcct gaaatgtgtg ggcgtggctt 4440 aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct gttttgcagc 4500 agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct catatttgac 4560 aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca gcattgatgg 4620 tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt ctggaacgcc 4680 gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc gcgggattgt 4740 gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt catccgcccg 4800 cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg aacttaatgt 4860 cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg cttcctcccc 4920 tcccaatgcg gtttaaaaca caacttttct atacaaagtt gtaaataaaa aaccagactc 4980 tgtttggatt tggatcaagc taagtgtctt gctgtcttta tttaggggtt ttgcgcgcgc 5040 ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct gtgtattttt tccaggacgt 5100 ggtaaaggtg actctggatg ttcagataca tgggcataag cccgtctctg gggtggaggt 5160 agcaccactg cagagcttca tgctgcgggg tggtgttgta gatgatccag tcgtagcagg 5220 agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa gctgattgcc aggggcaggc 5280 ccttggtgta agtgtttaca aagcggttaa gctgggatgg gtgcatacgt ggggatatga 5340 gatgcatctt ggactgtatt tttaggttgg ctatgttccc agccatatcc ctccggggat 5400 tcatgttgtg cagaaccacc agcacagtgt atccggtgca cttgggaaat ttgtcatgta 5460 gcttagaagg aaatgcgtgg aagaacttgg agacgccctt gtgacctcca agattttcca 5520 tgcattcgtc cataatgatg gcaatgggcc cacgggcggc ggcctgggcg aagatatttc 5580 tgggatcact aacgtcatag ttgtgttcca ggatgagatc gtcataggcc atttttacaa 5640 agcgcgggcg gagggtgcca gactgcggta taatggttcc atccggccca ggggcgtagt 5700 taccctcaca gatttgcatt tcccacgctt tgagttcaga tggggggatc atgtctacct 5760 gcggggcgat gaagaaaacg gtttccgggg taggggagat cagctgggaa gaaagcaggt 5820 tcctgagcag ctgcgactta ccgcagccgg tgggcccgta aatcacacct attaccggct 5880 gcaactggta gttaagagag ctgcagctgc cgtcatccct gagcaggggg gccacttcgt 5940 taagcatgtc cctgactcgc atgttttccc tgaccaaatc cgccagaagg cgctcgccgc 6000 ccagcgatag cagttcttgc aaggaagcaa agtttttcaa cggtttgaga ccgtccgccg 6060 taggcatgct tttgagcgtt tgaccaagca gttccaggcg gtcccacagc tcggtcacct 6120 gctctacggc atctcgatcc agcatatctc ctcgtttcgc gggttggggc ggctttcgct 6180 gtacggcagt agtcggtgct cgtccagacg ggccagggtc atgtctttcc acgggcgcag 6240 ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc gctccgggct gcgcgctggc 6300 cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc tgccggtctt cgccctgcgc 6360 gtcggccagg tagcatttga ccatggtgtc atagtccagc ccctccgcgg cgtggccctt 6420 ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg cagtgcagac ttttgagggc 6480 gtagagcttg ggcgcgagaa ataccgattc cggggagtag gcatccgcgc cgcaggcccc 6540 gcagacggtc tcgcattcca cgagccaggt gagctctggc cgttcggggt caaaaaccag 6600 gtttccccca tgctttttga tgcgtttctt acctctggtt tccatgagcc ggtgtccacg 6660 ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac ttgagaggcc tgtcctcgag 6720 cggtgttccg cggtcctcct cgtatagaaa ctcggaccac tctgagacaa aggctcgcgt 6780 ccaggccagc acgaaggagg ctaagtggga ggggtagcgg tcgttgtcca ctagggggtc 6840 cactcgctcc agggtgtgaa gacacatgtc gccctcttcg gcatcaagga aggtgattgg 6900 tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg gggctataaa agggggtggg 6960 ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg agggccagct gttggggtga 7020 gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga ttgtcagttt ccaaaaacga 7080 ggaggatttg atattcacct ggcccgcggt gatgcctttg agggtggccg catccatctg 7140 gtcagaaaag acaatctttt tgttgtcaag cttggtggca aacgacccgt agagggcgtt 7200 ggacagcaac ttggcgatgg agcgcagggt ttggtttttg tcgcgatcgg cgcgctcctt 7260 ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac cgccattcgg gaaagacggt 7320 ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg ttgtgcaggg tgacaaggtc 7380 aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc cagcagaggc ggccgccctt 7440 gcgcgagcag aatggcggta gggggtctag ctgcgtctcg tccggggggt ctgcgtccac 7500 ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct atcttgcatc cttgcaagtc 7560 tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg tatgggttga gtgggggacc 7620 ccatggcatg gggtgggtga gcgcggaggc gtacatgccg caaatgtcgt aaacgtagag 7680 gggctctctg agtattccaa gatatgtagg gtagcatctt ccaccgcgga tgctggcgcg 7740 cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg ggaccgaggt tgctacgggc 7800 gggctgctct gctcggaaga ctatctgcct gaagatggca tgtgagttgg atgatatggt 7860 tggacgctgg aagacgttga agctggcgtc tgtgagacct accgcgtcac gcacgaagga 7920 ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg acctgcacgt ctagggcgca 7980 gtagtccagg gtttccttga tgatgtcata cttatcctgt cccttttttt tccacagctc 8040 gcggttgagg acaaactctt cgcggtcttt ccagtactct tggatcggaa acccgtcggc 8100 ctccgaacgg taagagccta gcatgtagaa ctggttgacg gcctggtagg cgcagcatcc 8160 cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg agcgaggtgt gggtgagcgc 8220 aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg aagtcagtgt cgtcgcatcc 8280 gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa cgcggatttg gcagggcgaa 8340 ggtgacatcg ttgaagagta tctttcccgc gcgaggcata aagttgcgtg tgatgcggaa 8400 gggtcccggc acctcggaac ggttgttaat tacctgggcg gcgagcacga tctcgtcaaa 8460 gccgttgatg ttgtggccca caatgtaaag ttccaagaag cgcgggatgc ccttgatgga 8520 aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg gagctgagcc cgtgctctga 8580 aagggcccag tctgcaagat gagggttgga agcgacgaat gagctccaca ggtcacgggc 8640 cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg cgacctatgg ccattttttc 8700 tggggtgatg cagtagaagg taagcgggtc ttgttcccag cggtcccatc caaggttcgc 8760 ggctaggtct cgcgcggcag tcactagagg ctcatctccg ccgaacttca tgaccagcat 8820 gaagggcacg agctgcttcc caaaggcccc catccaagta taggtctcta catcgtaggt 8880 gacaaagaga cgctcggtgc gaggatgcga gccgatcggg aagaactgga tctcccgcca 8940 ccaattggag gagtggctat tgatgtggtg aaagtagaag tccctgcgac gggccgaaca 9000 ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag cggtgcacgg gctgtacatc 9060 ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag agtgggaatt tgagcccctc 9120 gcctggcggg tttggctggt ggtcttctac ttcggctgct tgtccttgac cgtctggctg 9180 ctcgagggga gttacggtgg atcggaccac cacgccgcgc gagcccaaag tccagatgtc 9240 cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga tgggagctgt ccatggtctg 9300 gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg tttacctcgc atagacgggt 9360 cagggcgcgg gctagatcca ggtgatacct aatttccagg ggctggttgg tggcggcgtc 9420 gatggcttgc aagaggccgc atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg 9480 ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt gacgcgggcg agcccccgga 9540 ggtagggggg gctccggacc cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg 9600 ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc 9660 tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag 9720 agttcgacag aatcaatttc ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg 9780 tctcctgagt tgtcttgata ggcgatctcg gccatgaact gctcgatctc ttcctcctgg 9840 agatctccgc gtccggctcg ctccacggtg gcggcgaggt cgttggaaat gcgggccatg 9900 agctgcgaga aggcgttgag gcctccctcg ttccagacgc ggctgtagac cacgccccct 9960 tcggcatcgc gggcgcgcat gaccacctgc gcgagattga gctccacgtg ccgggcgaag 10020 acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc 10080 acgaagaagt acataaccca gcgtcgcaac gtggattcgt tgatatcccc caaggcctca 10140 aggcgctcca tggcctcgta gaagtccacg gcgaagttga aaaactggga gttgcgcgcc 10200 gacacggtta actcctcctc cagaagacgg atgagctcgg cgacagtgtc gcgcacctcg 10260 cgctcaaagg ctacaggggc ctcttcttct tcttcaatct cctcttccat aagggcctcc 10320 ccttcttctt cttctggcgg cggtggggga ggggggacac ggcggcgacg acggcgcacc 10380 gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc gacggcgcat ggtctcggtg 10440 acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc cgcccgtcat gtcccggtta 10500 tgggttggcg gggggctgcc atgcggcagg gatacggcgc taacgatgca tctcaacaat 10560 tgttgtgtag gtactccgcc gccgagggac ctgagcgagt ccgcatcgac cggatcggaa 10620 aacctctcga gaaaggcgtc taaccagtca cagtcgcaag gtaggctgag caccgtggcg 10680 ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg tgctgctgat gatgtaatta 10740 aagtaggcgg tcttgagacg gcggatggtc gacagaagca ccatgtcctt gggtccggcc 10800 tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt tttgacatcg gcgcaggtct 10860 ttgtagtagt cttgcatgag cctttctacc ggcacttctt cttctccttc ctcttgtcct 10920 gcatctcttg catctatcgc tgcggcggcg gcggagtttg gccgtaggtg gcgccctctt 10980 cctcccatgc gtgtgacccc gaagcccctc atcggctgaa gcagggctag gtcggcgaca 11040 acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg tagactggaa gtcatccatg 11100 tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag tgcagttggc cataacggac 11160 cagttaacgg tctggtgacc cggctgcgag agctcggtgt acctgagacg cgagtaagcc 11220 ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt actggtatcc caccaaaaag 11280 tgcggcggcg gctggcggta gaggggccag cgtagggtgg ccggggctcc gggggcgaga 11340 tcttccaaca taaggcgatg atatccgtag atgtacctgg acatccaggt gatgccggcg 11400 gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc agatgttgcg cagcggcaaa 11460 aagtgctcca tggtcgggac gctctggccg gtcaggcgcg cgcaatcgtt gacgctctag 11520 accgtgcaaa aggagagcct gtaagcgggc actcttccgt ggtctggtgg ataaattcgc 11580 aagggtatca tggcggacga ccggggttcg agccccgtat ccggccgtcc gccgtgatcc 11640 atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg tcagacaacg ggggagtgct 11700 ccttttggct tccttccagg cgcggcggct gctgcgctag cttttttggc cactggccgc 11760 gcgcagcgta agcggttagg ctggaaagcg aaagcattaa gtggctcgct ccctgtagcc 11820 ggagggttat tttccaaggg ttgagtcgcg ggacccccgg ttcgagtctc ggaccggccg 11880 gactgcggcg aacgggggtt tgcctccccg tcatgcaaga ccccgcttgc aaattcctcc 11940 ggaaacaggg acgagcccct tttttgcttt tcccagatgc atccggtgct gcggcagatg 12000 cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc agacatgcag ggcaccctcc 12060 cctcctccta ccgcgtcagg aggggcgaca tccgcggttg acgcggcagc agatggtgat 12120 tacgaacccc cgcggcgccg ggcccggcac tacctggact tggaggaggg cgagggcctg 12180 gcgcggctag gagcgccctc tcctgagcgg cacccaaggg tgcagctgaa gcgtgatacg 12240 cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc gcgagggaga ggagcccgag 12300 gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc ggcatggcct gaatcgcgag 12360 cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa ccgggattag tcccgcgcgc 12420 gcacacgtgg cggccgccga cctggtaacc gcatacgagc agacggtgaa ccaggagatt 12480 aactttcaaa aaagctttaa caaccacgtg cgtacgcttg tggcgcgcga ggaggtggct 12540 ataggactga tgcatctgtg ggactttgta agcgcgctgg agcaaaaccc aaatagcaag 12600 ccgctcatgg cgcagctgtt ccttatagtg cagcacagca gggacaacga ggcattcagg 12660 gatgcgctgc taaacatagt agagcccgag ggccgctggc tgctcgattt gataaacatc 12720 ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg ctgacaaggt ggccgccatc 12780 aactattcca tgcttagcct gggcaagttt tacgcccgca agatatacca taccccttac 12840 gttcccatag acaaggaggt aaagatcgag gggttctaca tgcgcatggc gctgaaggtg 12900 cttaccttga gcgacgacct gggcgtttat cgcaacgagc gcatccacaa ggccgtgagc 12960 gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc acagcctgca aagggccctg 13020 gctggcacgg gcagcggcga tagagaggcc gagtcctact ttgacgcggg cgctgacctg 13080 cgctgggccc caagccgacg cgccctggag gcagctgggg ccggacctgg gctggcggtg 13140 gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat atgacgagga cgatgagtac 13200 gagccagagg acggcgagta ctaagcggtg atgtttctga tcagatgatg caagacgcaa 13260 cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc cggccttaac tccacggacg 13320 actggcgcca ggtcatggac cgcatcatgt cgctgactgc gcgcaatcct gacgcgttcc 13380 ggcagcagcc gcaggccaac cggctctccg caattctgga agcggtggtc ccggcgcgcg 13440 caaaccccac gcacgagaag gtgctggcga tcgtaaacgc gctggccgaa aacagggcca 13500 tccggcccga cgaggccggc ctggtctacg acgcgctgct tcagcgcgtg gctcgttaca 13560 acagcggcaa cgtgcagacc aacctggacc ggctggtggg ggatgtgcgc gaggccgtgg 13620 cgcagcgtga gcgcgcgcag cagcagggca acctgggctc catggttgca ctaaacgcct 13680 tcctgagtac acagcccgcc aacgtgccgc ggggacagga ggactacacc aactttgtga 13740 gcgcactgcg gctaatggtg actgagacac cgcaaagtga ggtgtaccag tctgggccag 13800 actatttttt ccagaccagt agacaaggcc tgcagaccgt aaacctgagc caggctttca 13860 aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg cgaccgcgcg accgtgtcta 13920 gcttgctgac gcccaactcg cgcctgttgc tgctgctaat agcgcccttc acggacagtg 13980 gcagcgtgtc ccgggacaca tacctaggtc acttgctgac actgtaccgc gaggccatag 14040 gtcaggcgca tgtggacgag catactttcc aggagattac aagtgtcagc cgcgcgctgg 14100 ggcaggagga cacgggcagc ctggaggcaa ccctaaacta cctgctgacc aaccggcggc 14160 agaagatccc ctcgttgcac agtttaaaca gcgaggagga gcgcattttg cgctacgtgc 14220 agcagagcgt gagccttaac ctgatgcgcg acggggtaac gcccagcgtg gcgctggaca 14280 tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa ccggccgttt atcaaccgcc 14340 taatggacta cttgcatcgc gcggccgccg tgaaccccga gtatttcacc aatgccatct 14400 tgaacccgca ctggctaccg ccccctggtt tctacaccgg gggattcgag gtgcccgagg 14460 gtaacgatgg attcctctgg gacgacatag acgacagcgt gttttccccg caaccgcaga 14520 ccctgctaga gttgcaacag cgcgagcagg cagaggcggc gctgcgaaag gaaagcttcc 14580 gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc gcggtcagat gctagtagcc 14640 catttccaag cttgataggg tctcttacca gcactcgcac cacccgcccg cgcctgctgg 14700 gcgaggagga gtacctaaac aactcgctgc tgcagccgca gcgcgaaaaa aacctgcctc 14760 cggcatttcc caacaacggg atagagagcc tagtggacaa gatgagtaga tggaagacgt 14820 acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc cacccgtcgt caaaggcacg 14880 accgtcagcg gggtctggtg tgggaggacg atgactcggc agacgacagc agcgtcctgg 14940 atttgggagg gagtggcaac ccgtttgcgc accttcgccc caggctgggg agaatgtttt 15000 aaaaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg gcaccgagcg 15060 ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg aaggtcctcc 15120 tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg gttctccctt 15180 cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta ccggggggag 15240 aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg tgtacctggt 15300 ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca gcaactttct 15360 gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac agaccatcaa 15420 tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata ccaacatgcc 15480 aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg tgtcgcgctt 15540 gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca cgctgcccga 15600 gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg tggagcacta 15660 cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa agtttgacac 15720 ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg gggtatatac 15780 aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg acttcaccca 15840 cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg agggctttag 15900 gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg tggacgccta 15960 ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg gcagcaacag 16020 cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc agccggtgga 16080 ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg aggagaagcg 16140 cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg aggtcgagaa 16200 gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac gcagttacaa 16260 cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg catacaacta 16320 cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg acgtaacctg 16380 cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg tgaccttccg 16440 ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc ccgtgcactc 16500 caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt ttacctctct 16560 gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc cagcccccac 16620 catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc taccgctgcg 16680 caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc gcacctgccc 16740 ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc gcactttttg 16800 agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc tgcgcttccc 16860 aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc gcgtgcgcgg 16920 gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca ccaccgtcga 16980 tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc cgccaccagt 17040 gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct atgctaaaat 17100 gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca ctgccgccca 17160 acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg cggccatgcg 17220 ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca ggcgacgagc 17280 ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg gcaacgtgta 17340 ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc ccccgcgcaa 17400 ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag cggcggcggc 17460 gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg tcatcgcgcc 17520 ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa agctaaagcg 17580 ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg aactgctgca 17640 cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac gtgttttgcg 17700 acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct acaagcgcgt 17760 gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc gcctcgggga 17820 gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg agggcaaccc 17880 aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg caccgtccga 17940 agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc agctgatggt 18000 acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac ctgggctgga 18060 gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg tgcagaccgt 18120 ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag agggcatgga 18180 gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg cggtcgctgc 18240 ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc gcgtttcagc 18300 cccccggcgc ccgcgccgtt cgaggaagta cggcgccgcc agcgcgctac tgcccgaata 18360 tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct accgccccag 18420 aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc gtcgccgtcg 18480 ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag gcaggaccct 18540 ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct ttgtggttct 18600 tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc gaggaagaat 18660 gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc gtgcgcacca 18720 ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc tccttattcc 18780 actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct tgcaggcgca 18840 gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt ctggactctc 18900 acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt gcgtctctgg 18960 ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc accagcaata 19020 tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat ttcggttcca 19080 ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg ctgagggata 19140 agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct ggcattagcg 19200 gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag cttgatcccc 19260 gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag gggcgtggcg 19320 aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac gagcctccct 19380 cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg cccatggcta 19440 ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc gccgacaccc 19500 agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct agccgcgcgt 19560 ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt ggcaactggc 19620 aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc cgacgatgct 19680 tctgaatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc gccagaggag 19740 ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga tgccgcagtg 19800 gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg ggctggtgca 19860 gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa accccacggt 19920 ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc ggttcatccc 19980 tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag ctgtgggtga 20040 taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc tggacagggg 20100 ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca agggtgcccc 20160 aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag aagaagagga 20220 cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc acgtatttgg 20280 gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag gtgtcgaagg 20340 tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag gagaatctca 20400 gtggtacgaa actgaaatta atcatgcagc tgggagagtc cttaaaaaga ctaccccaat 20460 gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc aaggcattct 20520 tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt tctcaactac 20580 tgaggcgacc gcaggcaatg gtgataactt gactcctaaa gtggtattgt acagtgaaga 20640 tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta aggaaggtaa 20700 ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca ttgcttttag 20760 ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg ttctggcggg 20820 ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag agctttcata 20880 ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt ggaatcaggc 20940 tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg aagatgaact 21000 tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta ccaaggtaaa 21060 acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt cagataaaaa 21120 tcaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca acctgtggag 21180 aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt acagtccttc 21240 caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc gagtggtggc 21300 tcccgggtta gtggactgct acattaacct tggagcacgc tggtcccttg actatatgga 21360 caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct caatgttgct 21420 gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct ttgccattaa 21480 aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga aggatgttaa 21540 catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca gcattaagtt 21600 tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg cctccacgct 21660 tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc tctccgccgc 21720 caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca tcccctcccg 21780 caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg aaaccccatc 21840 actgggctcg ggctacgacc cttattacac ctactctggc tctataccct acctagatgg 21900 aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact cttctgtcag 21960 ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc gctcagttga 22020 cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc tggtacaaat 22080 gctagctaac tacaacattg gctaccaggg cttctatatc ccagagagct acaaggaccg 22140 catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg atgatactaa 22200 atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg gatttgttgg 22260 ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc cctatccgct 22320 tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg atcgcaccct 22380 ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag acctgggcca 22440 aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg tggatcccat 22500 ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc gtgtgcaccg 22560 gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg ccggcaacgc 22620 cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc cagtgagcag 22680 gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg cacctatgac 22740 aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt caatacggcc 22800 ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca ctcaaaaaca 22860 tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt ttaccagttt 22920 gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg ctgtataacg 22980 ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg actattctgc 23040 tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca caaccccacc 23100 atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt acagcccacc 23160 ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc ctacttccgc 23220 agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa catgtaaaaa 23280 taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac tctcgggtga 23340 ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt ctgccgcgca 23400 tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct ccacttaaac 23460 tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct gcgcaccatc 23520 accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg gcctccgccc 23580 tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag cgccgggtgg 23640 tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc ctccgcgttg 23700 ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc gtgcccaggc 23760 tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt ctgggcgtta 23820 ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc ctttgcgcct 23880 tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca ggccgcgtcg 23940 tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc ccaccggttc 24000 ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt ttcgctcgtc 24060 acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag acacttaagc 24120 tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg ctcgtgatgc 24180 ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc catcatcgtc 24240 acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc gttcagccag 24300 gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa gttcgccttt 24360 agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat gcccttctcc 24420 cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact ttccgcttcg 24480 ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc gtcttcattc 24540 agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg tgggttgctg 24600 aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac gattacctct 24660 ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt gggcgcaatg 24720 gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac cagcgcgtct 24780 tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt ttttgggggc 24840 gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt tgggggacgt 24900 cgcgccgcac cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc ccgactggcc 24960 atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa ggacagccta 25020 accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc gcctaccacc 25080 ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca ggacccaggt 25140 tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa gcaagaccag 25200 gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca tggcgactac 25260 ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc cattatctgc 25320 gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag ccttgcctac 25380 gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg cacatgcgag 25440 cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct tgccacctat 25500 cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg cagccgagcg 25560 gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc gctcaacgaa 25620 gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa cgctctgcaa 25680 caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga gggtgacaac 25740 gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta cccggcactt 25800 aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg ccgtgcgcag 25860 cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc cgcagttggc 25920 gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga ggagcgacgc 25980 aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca gcggttcttt 26040 gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt tcgacagggc 26100 tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt ctcctacctt 26160 ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct caagggcgag 26220 gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac ctggcagacg 26280 gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct gcagaaactg 26340 ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt ggccgcgcac 26400 ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg tctgccagac 26460 ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg ctcaggaatc 26520 ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta ccgcgaatgc 26580 cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct tgcctaccac 26640 tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg tcgctgcaac 26700 ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga aagtcaaatt 26760 atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc tccggggttg 26820 aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc tgaggactac 26880 cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccaaatgc ggagcttacc 26940 gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa caaagcccgc 27000 caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc cggcgaggag 27060 ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc ccttgcttcc 27120 caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg aggaggaata 27180 ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga tggaagactg 27240 ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa caccgtcacc 27300 ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca gcatggctac 27360 aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc gtagatggga 27420 caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc aagagcaaca 27480 acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg cttgcttgca 27540 agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc acggcgtggc 27600 cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact gcaccggcgg 27660 cagcggcagc ggcagcaaca gcagcggcca cacagaagca aaggcgaccg gatagcaaga 27720 ctctgacaaa gcccaagaaa tccacagcgg cggcagcagc aggaggagga gcgctgcgtc 27780 tggcgcccaa cgaacccgta tcgacccgcg agcttagaaa caggattttt cccactctgt 27840 atgctatatt tcaacagagc aggggccaag aacaagagct gaaaataaaa aacaggtctc 27900 tgcgatccct cacccgcagc tgcctgtatc acaaaagcga agatcagctt cggcgcacgc 27960 tggaagacgc ggaggctctc ttcagtaaat actgcgcgct gactcttaag gactagtttc 28020 gcgccctttc tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca cacccggcgc 28080 cagcacctgt cgtcagcgcc atttcaactt tgtatacaaa agttgtgatg agcaaggaaa 28140 ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct ggagctgccc 28200 aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata tcccgggtca 28260 acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt accaccacac 28320 ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg 28380 ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg actaactcag 28440 gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag ggtataactc 28500 acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg 28560 gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca ttcacgcctc 28620 gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga ggcattggaa 28680 ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc tcgggacctc 28740 ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac tcggcggacg 28800 gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact 28860 gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt gaattgcccg 28920 aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga gagcttgccc 28980 gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac aggggaccct 29040 gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat ctttgttgcc 29100 atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc ctatcgccat 29160 cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt acctggtact 29220 tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt gagtctacga 29280 gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct tacctgccgg 29340 gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg taaaccagac 29400 tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc ttagaaaacc 29460 cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt caagcaactc 29520 tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc tctgtcttgt 29580 gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct gctgtgtgca 29640 catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat gattaggtac 29700 ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa ggtggatttt 29760 aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac cactcttata 29820 aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat tggcaagtat 29880 gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac agttttccag 29940 ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg cgacattacc 30000 atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga aaacactggc 30060 actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac cctactctat 30120 attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta atttactaag 30180 ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca aattcaaaaa 30240 gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct caataccatt 30300 cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg aagtcaggct 30360 tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt tccagtccaa 30420 ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc cgctaccgga 30480 cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg ggataacttg 30540 ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat gtggctcatc 30600 tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat tgtgctacac 30660 ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt ttctcttaca 30720 gtatgattaa atgagacatg attcctcgag tttttatatt actgaccctt gttgcgcttt 30780 tttgtgcgtg ctccacattg gctgcggttt ctcacatcga agtagactgc attccagcct 30840 tcacagtcta tttgctttac ggatttgtca ccctcacgct catctgcagc ctcatcactg 30900 tggtcatcgc ctttatccag tgcattgact gggtctgtgt gcgctttgca tatctcagac 30960 accatcccca gtacagggac aggactatag ctgagcttct tagaattctt taattatgaa 31020 atttactgtg acttttctgc tgattatttg caccctatct gcgttttgtt ccccgacctc 31080 caagcctcaa agacatatat catgcagatt cactcgtata tggaatattc caagttgcta 31140 caatgaaaaa agcgatcttt ccgaagcctg gttatatgca atcatctctg ttatggtgtt 31200 ctgcagtacc atcttagccc tagctatata tccctacctt gacattggct ggaacgcaat 31260 agatgccatg aaccacccaa ctttccccgc gcccgctatg cttccactgc aacaagttgt 31320 tgccggcggc tttgtcccag ccaatcagcc tcgcccacct tctcccaccc ccactgaaat 31380 cagctacttt aatctaacag gaggagatga ctgacaccct agatctagaa atggacggaa 31440 ttattacaga gcagcgcctg ctagaaagac gcagggcagc ggccgagcaa cagcgcatga 31500 atcaagagct ccaagacatg gttaacttgc accagtgcaa aaggggtatc ttttgtctgg 31560 taaagcaggc caaagtcacc tacgacagta ataccaccgg acaccgcctt agctacaagt 31620 tgccaaccaa gcgtcagaaa ttggtggtca tggtgggaga aaagcccatt accataactc 31680 agcactcggt agaaaccgaa ggctgcattc actcaccttg tcaaggacct gaggatctct 31740 gcacccttat taagaccctg tgcggtctca aagatcttat tccctttaac taataaaaaa 31800 aaataataaa gcatcactta cttaaaatca gttagcaaat ttctgtccag tttattcagc 31860 agcacctcct tgccctcctc ccagctctgg tattgcagct tcctcctggc tgcaaacttt 31920 ctccacaatc taaatggaat gtcagtttcc tcctgttcct gtccatccgc acccactatc 31980 ttcatgttgt tgcagatgaa gcgcgcaaga ccgtctgaag ataccttcaa ccccgtgtat 32040 ccatatgaca cggaaaccgg tcctccaact gtgccttttc ttactcctcc ctttgtatcc 32100 cccaatgggt ttcaagagag tccccctggg gtactctctt tgcgcctatc cgaacctcta 32160 gttacctcca atggcatgct tgcgctcaaa atgggcaacg gcctctctct ggacgaggcc 32220 ggcaacctta cctcccaaaa tgtaaccact gtgagcccac ctctcaaaaa aaccaagtca 32280 aacataaacc tggaaatatc tgcacccctc acagttacct cagaagccct aactgtggct 32340 gccgccgcac ctctaatggt cgcgggcaac acactcacca tgcaatcaca ggccccgcta 32400 accgtgcacg actccaaact tagcattgcc acccaaggac ccctcacagt gtcagaagga 32460 aagctagccc tgcaaacatc aggccccctc accaccaccg atagcagtac ccttactatc 32520 actgcctcac cccctctaac tactgccact ggtagcttgg gcattgactt gaaagagccc 32580 atttatacac aaaatggaaa actaggacta aagtacgggg ctcctttgca tgtaacagac 32640 gacctaaaca ctttgaccgt agcaactggt ccaggtgtga ctattaataa tacttccttg 32700 caaactaaag ttactggagc cttgggtttt gattcacaag gcaatatgca acttaatgta 32760 gcaggaggac taaggattga ttctcaaaac agacgcctta tacttgatgt tagttatccg 32820 tttgatgctc aaaaccaact aaatctaaga ctaggacagg gccctctttt tataaactca 32880 gcccacaact tggatattaa ctacaacaaa ggcctttact tgtttacagc ttcaaacaat 32940 tccaaaaagc ttgaggttaa cctaagcact gccaaggggt tgatgtttga cgctacagcc 33000 atagccatta atgcaggaga tgggcttgaa tttggttcac ctaatgcacc aaacacaaat 33060 cccctcaaaa caaaaattgg ccatggccta gaatttgatt caaacaaggc tatggttcct 33120 aaactaggaa ctggccttag ttttgacagc acaggtgcca ttacagtagg aaacaaaaat 33180 aatgataagc taactttatg gacaactcct gacccaccac caaactgcag cctcatacaa 33240 gagctagatg caaaactcac cctgtgctta acaaaaaacg gatctattgt taatggcatt 33300 gtaagtttag tgggtgttaa gggtaatctc ctaaatatcc aaagtactac taccactgta 33360 ggagtgcatt tagtgtttga tgaacaggga agattaatca catcaacccc tactgccctg 33420 gttccccaag cttcgtgggg atatagacaa ggccaatcag tgtctaccaa tactgttacc 33480 aatggtctag gttttatgcc taatgtgagt gcttacccta gaccaaatgc cagtgaggct 33540 aaaagccaaa tggtaagtct cacgtactta cagggagata catctaaacc tataacaatg 33600 aaagttgcat ttaatggcat tacgtcgcta aatggatact ctttaacatt catgtggtca 33660 ggtctatcaa actatataaa tcagcctttc tctacaccat cctgctcctt ttcttacatt 33720 acccaagaat aataaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca 33780 gaaaatttca agtcattttt cattcagtag tatagcccca ccaccacata gcttatacag 33840 atcaccgtac ctcaactttg tataataaag ttgtaatcaa actcacagaa ccctagtatt 33900 caacctgcca cctccctccc aacacacaga gtacacagtc ctttctcccc ggctggcctt 33960 aaaaagcatc atatcatggg taacagacat attcttaggt gttatattcc acacggtttc 34020 ctgtcgagcc aaacgctcat cagtgatatt aataaactcc ccgggcagct cacttaagtt 34080 catgtcgctg tccagctgct gagccacagg ctgctgtcca acttgcggtt gcttaacggg 34140 cggcgaagga gaagtccacg cctacatggg ggtagagtca taatcgtgca tcaggatagg 34200 gcggtggtgc tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga 34260 atacaacatg gcagtggtct cctcagcgat gattcgcacc gcccgcagca taaggcgcct 34320 tgtcctccgg gcacagcagc gcaccctgat ctcacttaaa tcagcacagt aactgcagca 34380 cagcaccaca atattgttca aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc 34440 ggggaccaca gaacccacgt ggccatcata ccacaagcgc aggtagatta agtggcgacc 34500 cctcataaac acgctggaca taaacattac ctcttttggc atgttgtaat tcaccacctc 34560 ccggtaccat ataaacctct gattaaacat ggcgccatcc accaccatcc taaaccagct 34620 ggccaaaacc tgcccgccgg ctatacactg cagggaaccg ggactggaac aatgacagtg 34680 gagagcccag gactcgtaac catggatcat catgctcgtc atgatatcaa tgttggcaca 34740 acacaggcac acgtgcatac acttcctcag gattacaagc tcctcccgcg ttagaaccat 34800 atcccaggga acaacccatt cctgaatcag cgtaaatccc acactgcagg gaagacctcg 34860 cacgtaactc acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc 34920 cagtatggta gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac tgtacggagt 34980 gcgccgagac aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt 35040 agtcatattt cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg cgtctccggt 35100 ctcgccgctt agatcgctct gtgtagtagt tgtagtatat ccactctctc aaagcatcca 35160 ggcgccccct ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc ctgataacat 35220 ccaccaccgc agaataagcc acacccagcc aacctacaca ttcgttctgc gagtcacaca 35280 cgggaggagc gggaagagct ggaagaacca tgtttttttt tttattccaa aagattatcc 35340 aaaacctcaa aatgaagatc tattaagtga acgcgctccc ctccggtggc gtggtcaaac 35400 tctacagcca aagaacagat aatggcattt gtaagatgtt gcacaatggc ttccaaaagg 35460 caaacggccc tcacgtccaa gtggacgtaa aggctaaacc cttcagggtg aatctcctct 35520 ataaacattc cagcaccttc aaccatgccc aaataattct catctcgcca ccttctcaat 35580 atatctctaa gcaaatcccg aatattaagt ccggccattg taaaaatctg ctccagagcg 35640 ccctccacct tcagcctcaa gcagcgaatc atgattgcaa aaattcaggt tcctcacaga 35700 cctgtataag attcaaaagc ggaacattaa caaaaatacc gcgatcccgt aggtcccttc 35760 gcagggccag ctgaacataa tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc 35820 caggaaccat gacaaaagaa cccacactga ttatgacacg catactcgga gctatgctaa 35880 ccagcgtagc cccgatgtaa gcttgttgca tgggcggcga tataaaatgc aaggtgctgc 35940 tcaaaaaatc aggcaaagcc tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca 36000 gataaaggca ggtaagctcc ggaaccacca cagaaaaaga caccattttt ctctcaaaca 36060 tgtctgcggg tttctgcata aacacaaaat aaaataacaa aaaaacattt aaacattaga 36120 agcctgtctt acaacaggaa aaacaaccct tataagcata agacggacta cggccatgcc 36180 ggcgtgaccg taaaaaaact ggtcaccgtg attaaaaagc accaccgaca gctcctcggt 36240 catgtccgga gtcataatgt aagactcggt aaacacatca ggttgattca catcggtcag 36300 tgctaaaaag cgaccgaaat agcccggggg aatacatacc cgcaggcgta gagacaacat 36360 tacagccccc ataggaggta taacaaaatt aataggagag aaaaacacat aaacacctga 36420 aaaaccctcc tgcctaggca aaatagcacc ctcccgctcc agaacaacat acagcgcttc 36480 cacagcggca gccataacag tcagccttac cagtaaaaaa gaaaacctat taaaaaaaca 36540 ccactcgaca cggcaccagc tcaatcagtc acagtgtaaa aaagggccaa gtgcagagcg 36600 agtatatata ggactaaaaa atgacgtaac ggttaaagtc cacaaaaaac acccagaaaa 36660 ccgcacgcga acctacgccc agaaacgaaa gccaaaaaac ccacaacttc ctcaaatcgt 36720 cacttccgtt ttcccacgtt acgtcacttc ccattttaag aaaactacaa ttcccaacac 36780 atacaagtta ctccgcccta aaacctacgt cacccgcccc gttcccacgc cccgcgccac 36840 gtcacaaact ccaccccctc attatcatat tggcttcaat ccaaaataag gtatattatt 36900 gatgatg 36907 <210> 73 <211> 36943 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO176) <400> 73 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattaaac cgtattaccg ccatgcattt aatggagtgc 480 ctcgtgaggc tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa 540 gttgggggga ggggtcggca attgaaccgg tgcctagaga aggtggcgcg gggtaaactg 600 ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat 660 aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacaggt 720 aagtgccgtg tgtggttccc gcgggcctgg cctctttacg ggttatggcc cttgcgtgcc 780 ttgaattact tccacctggc tgcagtacgt gattcttgat cccgagcttc gggttggaag 840 tgggtgggag agttcgaggc cttgcgctta aggagcccct tcgcctcgtg cttgagttga 900 ggcctggcct gggcgctggg gccgccgcgt gcgaatctgg tggcaccttc gcgcctgtct 960 cgctgctttc gataagtctc tagccattta aaatttttga tgacctgctg cgacgctttt 1020 tttctggcaa gatagtcttg taaatgcggg ccaagatctg cacactggta tttcggtttt 1080 tggggccgcg ggcggcgacg gggcccgtgc gtcccagcgc acatgttcgg cgaggcgggg 1140 cctgcgagcg cggccaccga gaatcggacg ggggtagtct caagctggcc ggcctgctct 1200 ggtgcctggc ctcgcgccgc cgtgtatcgc cccgccctgg gcggcaaggc tggcccggtc 1260 ggcaccagtt gcgtgagcgg aaagatggcc gcttcccggc cctgctgcag ggagctcaaa 1320 atggaggacg cggcgctcgg gagagcgggc gggtgagtca cccacacaaa ggaaaagggc 1380 ctttccgtcc tcagccgtcg cttcatgtga ctccacggag taccgggcgc cgtccaggca 1440 cctcgattag ttctcgagct tttggagtac gtcgtcttta ggttgggggg aggggtttta 1500 tgcgatggag tttccccaca ctgagtgggt ggagactgaa gttaggccag cttggcactt 1560 gatgtaattc tccttggaat ttgccctttt tgagtttgga tcttggttca ttctcaagcc 1620 tcagacagtg gttcaaagtt tttttcttcc atttcaggtg tcgtgacgct agcgctaccg 1680 gactcagatc tcgagctcaa gcttcgaatt ctgcagtcga cggtaccgga tccatggaag 1740 acgccaaaaa cataaagaaa ggcccggcgc cattctatcc gctggaagat ggaaccgctg 1800 gagagcaact gcataaggct atgaagagat acgccctggt tcctggaaca attgctttta 1860 cagatgcaca tatcgaggtg gacatcactt acgctgagta cttcgaaatg tccgttcggt 1920 tggcagaagc tatgaaacga tatgggctga atacaaatca cagaatcgtc gtatgcagtg 1980 aaaactctct tcaattcttt atgccggtgt tgggcgcgtt atttatcgga gttgcagttg 2040 cgcccgcgaa cgacatttat aatgaacgtg aattgctcaa cagtatgggc atttcgcagc 2100 ctaccgtggt gttcgtttcc aaaaaggggt tgcaaaaaat tttgaacgtg caaaaaaagc 2160 tcccaatcat ccaaaaaatt attatcatgg attctaaaac ggattaccag ggatttcagt 2220 cgatgtacac gttcgtcaca tctcatctac ctcccggttt taatgaatac gattttgtgc 2280 cagagtcctt cgatagggac aagacaattg cactgatcat gaactcctct ggatctactg 2340 gtctgcctaa aggtgtcgct ctgcctcata gaactgcctg cgtgagattc tcgcatgcca 2400 gagatcctat ttttggcaat caaatcattc cggatactgc gattttaagt gttgttccat 2460 tccatcacgg ttttggaatg tttactacac tcggatattt gatatgtgga tttcgagtcg 2520 tcttaatgta tagatttgaa gaagagctgt ttctgaggag ccttcaggat tacaagattc 2580 aaagtgcgct gctggtgcca accctattct ccttcttcgc caaaagcact ctgattgaca 2640 aatacgattt atctaattta cacgaaattg cttctggtgg cgctcccctc tctaaggaag 2700 tcggggaagc ggttgccaag aggttccatc tgccaggtat caggcaagga tatgggctca 2760 ctgagactac atcagctatt ctgattacac ccgaggggga tgataaaccg ggcgcggtcg 2820 gtaaagttgt tccatttttt gaagcgaagg ttgtggatct ggataccggg aaaacgctgg 2880 gcgttaatca aagaggcgaa ctgtgtgtga gaggtcctat gattatgtcc ggttatgtaa 2940 acaatccgga agcgaccaac gccttgattg acaaggatgg atggctacat tctggagaca 3000 tagcttactg ggacgaagac gaacacttct tcatcgttga ccgcctgaag tctctgatta 3060 agtacaaagg ctatcaggtg gctcccgctg aattggaatc catcttgctc caacacccca 3120 acatcttcga cgcaggtgtc gcaggtcttc ccgacgatga cgccggtgaa cttcccgccg 3180 ccgttgttgt tttggagcac ggaaagacga tgacggaaaa agagatcgtg gattacgtcg 3240 ccagtcaagt aacaaccgcg aaaaagttgc gcggaggagt tgtgtttgtg gacgaagtac 3300 cgaaaggtct taccggaaaa ctcgacgcaa gaaaaatcag agagatcctc ataaaggcca 3360 agaagggcgg aaagatcgcc gtggcagccg cagccaccat ggtgagcaag ggcgaggagc 3420 tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac ggccacaagt 3480 tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca 3540 tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc ctgacctacg 3600 gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc ttcaagtccg 3660 ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac ggcaactaca 3720 agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc gagctgaagg 3780 gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca 3840 gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg aacttcaaga 3900 tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag cagaacaccc 3960 ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc cagtccgccc 4020 tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc gtgaccgccg 4080 ccgggatcac tctcggcatg gacgagctgt acaagtaaag cgactctaga tcataatcag 4140 ccatacccaa acaccattgt cacactccaa tcgattcaaa caccattgtc acactccaac 4200 atttgtagag gttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca 4260 taaaatgaat gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata 4320 aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg 4380 tttgtccaaa ctcatcaatg taagtttaaa cggcgcgcct gaaatgtgtg ggcgtggctt 4440 aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct gttttgcagc 4500 agccgccgcc gccatgagca ccaactcgtt tgatggaagc attgtgagct catatttgac 4560 aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg atgggctcca gcattgatgg 4620 tcgccccgtc ctgcccgcaa actctactac cttgacctac gagaccgtgt ctggaacgcc 4680 gttggagact gcagcctccg ccgccgcttc agccgctgca gccaccgccc gcgggattgt 4740 gactgacttt gctttcctga gcccgcttgc aagcagtgca gcttcccgtt catccgcccg 4800 cgatgacaag ttgacggctc ttttggcaca attggattct ttgacccggg aacttaatgt 4860 cgtttctcag cagctgttgg atctgcgcca gcaggtttct gccctgaagg cttcctcccc 4920 tcccaatgcg gtttaaaaca caacttttct atacaaagtt gtaaataaaa aaccagactc 4980 tgtttggatt tggatcaagc taagtgtctt gctgtcttta tttaggggtt ttgcgcgcgc 5040 ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct gtgtattttt tccaggacgt 5100 ggtaaaggtg actctggatg ttcagataca tgggcataag cccgtctctg gggtggaggt 5160 agcaccactg cagagcttca tgctgcgggg tggtgttgta gatgatccag tcgtagcagg 5220 agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa gctgattgcc aggggcaggc 5280 ccttggtgta agtgtttaca aagcggttaa gctgggatgg gtgcatacgt ggggatatga 5340 gatgcatctt ggactgtatt tttaggttgg ctatgttccc agccatatcc ctccggggat 5400 tcatgttgtg cagaaccacc agcacagtgt atccggtgca cttgggaaat ttgtcatgta 5460 gcttagaagg aaatgcgtgg aagaacttgg agacgccctt gtgacctcca agattttcca 5520 tgcattcgtc cataatgatg gcaatgggcc cacgggcggc ggcctgggcg aagatatttc 5580 tgggatcact aacgtcatag ttgtgttcca ggatgagatc gtcataggcc atttttacaa 5640 agcgcgggcg gagggtgcca gactgcggta taatggttcc atccggccca ggggcgtagt 5700 taccctcaca gatttgcatt tcccacgctt tgagttcaga tggggggatc atgtctacct 5760 gcggggcgat gaagaaaacg gtttccgggg taggggagat cagctgggaa gaaagcaggt 5820 tcctgagcag ctgcgactta ccgcagccgg tgggcccgta aatcacacct attaccggct 5880 gcaactggta gttaagagag ctgcagctgc cgtcatccct gagcaggggg gccacttcgt 5940 taagcatgtc cctgactcgc atgttttccc tgaccaaatc cgccagaagg cgctcgccgc 6000 ccagcgatag cagttcttgc aaggaagcaa agtttttcaa cggtttgaga ccgtccgccg 6060 taggcatgct tttgagcgtt tgaccaagca gttccaggcg gtcccacagc tcggtcacct 6120 gctctacggc atctcgatcc agcatatctc ctcgtttcgc gggttggggc ggctttcgct 6180 gtacggcagt agtcggtgct cgtccagacg ggccagggtc atgtctttcc acgggcgcag 6240 ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc gctccgggct gcgcgctggc 6300 cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc tgccggtctt cgccctgcgc 6360 gtcggccagg tagcatttga ccatggtgtc atagtccagc ccctccgcgg cgtggccctt 6420 ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg cagtgcagac ttttgagggc 6480 gtagagcttg ggcgcgagaa ataccgattc cggggagtag gcatccgcgc cgcaggcccc 6540 gcagacggtc tcgcattcca cgagccaggt gagctctggc cgttcggggt caaaaaccag 6600 gtttccccca tgctttttga tgcgtttctt acctctggtt tccatgagcc ggtgtccacg 6660 ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac ttgagaggcc tgtcctcgag 6720 cggtgttccg cggtcctcct cgtatagaaa ctcggaccac tctgagacaa aggctcgcgt 6780 ccaggccagc acgaaggagg ctaagtggga ggggtagcgg tcgttgtcca ctagggggtc 6840 cactcgctcc agggtgtgaa gacacatgtc gccctcttcg gcatcaagga aggtgattgg 6900 tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg gggctataaa agggggtggg 6960 ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg agggccagct gttggggtga 7020 gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga ttgtcagttt ccaaaaacga 7080 ggaggatttg atattcacct ggcccgcggt gatgcctttg agggtggccg catccatctg 7140 gtcagaaaag acaatctttt tgttgtcaag cttggtggca aacgacccgt agagggcgtt 7200 ggacagcaac ttggcgatgg agcgcagggt ttggtttttg tcgcgatcgg cgcgctcctt 7260 ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac cgccattcgg gaaagacggt 7320 ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg ttgtgcaggg tgacaaggtc 7380 aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc cagcagaggc ggccgccctt 7440 gcgcgagcag aatggcggta gggggtctag ctgcgtctcg tccggggggt ctgcgtccac 7500 ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct atcttgcatc cttgcaagtc 7560 tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg tatgggttga gtgggggacc 7620 ccatggcatg gggtgggtga gcgcggaggc gtacatgccg caaatgtcgt aaacgtagag 7680 gggctctctg agtattccaa gatatgtagg gtagcatctt ccaccgcgga tgctggcgcg 7740 cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg ggaccgaggt tgctacgggc 7800 gggctgctct gctcggaaga ctatctgcct gaagatggca tgtgagttgg atgatatggt 7860 tggacgctgg aagacgttga agctggcgtc tgtgagacct accgcgtcac gcacgaagga 7920 ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg acctgcacgt ctagggcgca 7980 gtagtccagg gtttccttga tgatgtcata cttatcctgt cccttttttt tccacagctc 8040 gcggttgagg acaaactctt cgcggtcttt ccagtactct tggatcggaa acccgtcggc 8100 ctccgaacgg taagagccta gcatgtagaa ctggttgacg gcctggtagg cgcagcatcc 8160 cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg agcgaggtgt gggtgagcgc 8220 aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg aagtcagtgt cgtcgcatcc 8280 gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa cgcggatttg gcagggcgaa 8340 ggtgacatcg ttgaagagta tctttcccgc gcgaggcata aagttgcgtg tgatgcggaa 8400 gggtcccggc acctcggaac ggttgttaat tacctgggcg gcgagcacga tctcgtcaaa 8460 gccgttgatg ttgtggccca caatgtaaag ttccaagaag cgcgggatgc ccttgatgga 8520 aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg gagctgagcc cgtgctctga 8580 aagggcccag tctgcaagat gagggttgga agcgacgaat gagctccaca ggtcacgggc 8640 cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg cgacctatgg ccattttttc 8700 tggggtgatg cagtagaagg taagcgggtc ttgttcccag cggtcccatc caaggttcgc 8760 ggctaggtct cgcgcggcag tcactagagg ctcatctccg ccgaacttca tgaccagcat 8820 gaagggcacg agctgcttcc caaaggcccc catccaagta taggtctcta catcgtaggt 8880 gacaaagaga cgctcggtgc gaggatgcga gccgatcggg aagaactgga tctcccgcca 8940 ccaattggag gagtggctat tgatgtggtg aaagtagaag tccctgcgac gggccgaaca 9000 ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag cggtgcacgg gctgtacatc 9060 ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag agtgggaatt tgagcccctc 9120 gcctggcggg tttggctggt ggtcttctac ttcggctgct tgtccttgac cgtctggctg 9180 ctcgagggga gttacggtgg atcggaccac cacgccgcgc gagcccaaag tccagatgtc 9240 cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga tgggagctgt ccatggtctg 9300 gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg tttacctcgc atagacgggt 9360 cagggcgcgg gctagatcca ggtgatacct aatttccagg ggctggttgg tggcggcgtc 9420 gatggcttgc aagaggccgc atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg 9480 ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt gacgcgggcg agcccccgga 9540 ggtagggggg gctccggacc cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg 9600 ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc 9660 tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg tgagcttgaa cctgaaagag 9720 agttcgacag aatcaatttc ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg 9780 tctcctgagt tgtcttgata ggcgatctcg gccatgaact gctcgatctc ttcctcctgg 9840 agatctccgc gtccggctcg ctccacggtg gcggcgaggt cgttggaaat gcgggccatg 9900 agctgcgaga aggcgttgag gcctccctcg ttccagacgc ggctgtagac cacgccccct 9960 tcggcatcgc gggcgcgcat gaccacctgc gcgagattga gctccacgtg ccgggcgaag 10020 acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc 10080 acgaagaagt acataaccca gcgtcgcaac gtggattcgt tgatatcccc caaggcctca 10140 aggcgctcca tggcctcgta gaagtccacg gcgaagttga aaaactggga gttgcgcgcc 10200 gacacggtta actcctcctc cagaagacgg atgagctcgg cgacagtgtc gcgcacctcg 10260 cgctcaaagg ctacaggggc ctcttcttct tcttcaatct cctcttccat aagggcctcc 10320 ccttcttctt cttctggcgg cggtggggga ggggggacac ggcggcgacg acggcgcacc 10380 gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc gacggcgcat ggtctcggtg 10440 acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc cgcccgtcat gtcccggtta 10500 tgggttggcg gggggctgcc atgcggcagg gatacggcgc taacgatgca tctcaacaat 10560 tgttgtgtag gtactccgcc gccgagggac ctgagcgagt ccgcatcgac cggatcggaa 10620 aacctctcga gaaaggcgtc taaccagtca cagtcgcaag gtaggctgag caccgtggcg 10680 ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg tgctgctgat gatgtaatta 10740 aagtaggcgg tcttgagacg gcggatggtc gacagaagca ccatgtcctt gggtccggcc 10800 tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt tttgacatcg gcgcaggtct 10860 ttgtagtagt cttgcatgag cctttctacc ggcacttctt cttctccttc ctcttgtcct 10920 gcatctcttg catctatcgc tgcggcggcg gcggagtttg gccgtaggtg gcgccctctt 10980 cctcccatgc gtgtgacccc gaagcccctc atcggctgaa gcagggctag gtcggcgaca 11040 acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg tagactggaa gtcatccatg 11100 tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag tgcagttggc cataacggac 11160 cagttaacgg tctggtgacc cggctgcgag agctcggtgt acctgagacg cgagtaagcc 11220 ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt actggtatcc caccaaaaag 11280 tgcggcggcg gctggcggta gaggggccag cgtagggtgg ccggggctcc gggggcgaga 11340 tcttccaaca taaggcgatg atatccgtag atgtacctgg acatccaggt gatgccggcg 11400 gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc agatgttgcg cagcggcaaa 11460 aagtgctcca tggtcgggac gctctggccg gtcaggcgcg cgcaatcgtt gacgctctag 11520 accgtgcaaa aggagagcct gtaagcgggc actcttccgt ggtctggtgg ataaattcgc 11580 aagggtatca tggcggacga ccggggttcg agccccgtat ccggccgtcc gccgtgatcc 11640 atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg tcagacaacg ggggagtgct 11700 ccttttggct tccttccagg cgcggcggct gctgcgctag cttttttggc cactggccgc 11760 gcgcagcgta agcggttagg ctggaaagcg aaagcattaa gtggctcgct ccctgtagcc 11820 ggagggttat tttccaaggg ttgagtcgcg ggacccccgg ttcgagtctc ggaccggccg 11880 gactgcggcg aacgggggtt tgcctccccg tcatgcaaga ccccgcttgc aaattcctcc 11940 ggaaacaggg acgagcccct tttttgcttt tcccagatgc atccggtgct gcggcagatg 12000 cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc agacatgcag ggcaccctcc 12060 cctcctccta ccgcgtcagg aggggcgaca tccgcggttg acgcggcagc agatggtgat 12120 tacgaacccc cgcggcgccg ggcccggcac tacctggact tggaggaggg cgagggcctg 12180 gcgcggctag gagcgccctc tcctgagcgg cacccaaggg tgcagctgaa gcgtgatacg 12240 cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc gcgagggaga ggagcccgag 12300 gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc ggcatggcct gaatcgcgag 12360 cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa ccgggattag tcccgcgcgc 12420 gcacacgtgg cggccgccga cctggtaacc gcatacgagc agacggtgaa ccaggagatt 12480 aactttcaaa aaagctttaa caaccacgtg cgtacgcttg tggcgcgcga ggaggtggct 12540 ataggactga tgcatctgtg ggactttgta agcgcgctgg agcaaaaccc aaatagcaag 12600 ccgctcatgg cgcagctgtt ccttatagtg cagcacagca gggacaacga ggcattcagg 12660 gatgcgctgc taaacatagt agagcccgag ggccgctggc tgctcgattt gataaacatc 12720 ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg ctgacaaggt ggccgccatc 12780 aactattcca tgcttagcct gggcaagttt tacgcccgca agatatacca taccccttac 12840 gttcccatag acaaggaggt aaagatcgag gggttctaca tgcgcatggc gctgaaggtg 12900 cttaccttga gcgacgacct gggcgtttat cgcaacgagc gcatccacaa ggccgtgagc 12960 gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc acagcctgca aagggccctg 13020 gctggcacgg gcagcggcga tagagaggcc gagtcctact ttgacgcggg cgctgacctg 13080 cgctgggccc caagccgacg cgccctggag gcagctgggg ccggacctgg gctggcggtg 13140 gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat atgacgagga cgatgagtac 13200 gagccagagg acggcgagta ctaagcggtg atgtttctga tcagatgatg caagacgcaa 13260 cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc cggccttaac tccacggacg 13320 actggcgcca ggtcatggac cgcatcatgt cgctgactgc gcgcaatcct gacgcgttcc 13380 ggcagcagcc gcaggccaac cggctctccg caattctgga agcggtggtc ccggcgcgcg 13440 caaaccccac gcacgagaag gtgctggcga tcgtaaacgc gctggccgaa aacagggcca 13500 tccggcccga cgaggccggc ctggtctacg acgcgctgct tcagcgcgtg gctcgttaca 13560 acagcggcaa cgtgcagacc aacctggacc ggctggtggg ggatgtgcgc gaggccgtgg 13620 cgcagcgtga gcgcgcgcag cagcagggca acctgggctc catggttgca ctaaacgcct 13680 tcctgagtac acagcccgcc aacgtgccgc ggggacagga ggactacacc aactttgtga 13740 gcgcactgcg gctaatggtg actgagacac cgcaaagtga ggtgtaccag tctgggccag 13800 actatttttt ccagaccagt agacaaggcc tgcagaccgt aaacctgagc caggctttca 13860 aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg cgaccgcgcg accgtgtcta 13920 gcttgctgac gcccaactcg cgcctgttgc tgctgctaat agcgcccttc acggacagtg 13980 gcagcgtgtc ccgggacaca tacctaggtc acttgctgac actgtaccgc gaggccatag 14040 gtcaggcgca tgtggacgag catactttcc aggagattac aagtgtcagc cgcgcgctgg 14100 ggcaggagga cacgggcagc ctggaggcaa ccctaaacta cctgctgacc aaccggcggc 14160 agaagatccc ctcgttgcac agtttaaaca gcgaggagga gcgcattttg cgctacgtgc 14220 agcagagcgt gagccttaac ctgatgcgcg acggggtaac gcccagcgtg gcgctggaca 14280 tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa ccggccgttt atcaaccgcc 14340 taatggacta cttgcatcgc gcggccgccg tgaaccccga gtatttcacc aatgccatct 14400 tgaacccgca ctggctaccg ccccctggtt tctacaccgg gggattcgag gtgcccgagg 14460 gtaacgatgg attcctctgg gacgacatag acgacagcgt gttttccccg caaccgcaga 14520 ccctgctaga gttgcaacag cgcgagcagg cagaggcggc gctgcgaaag gaaagcttcc 14580 gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc gcggtcagat gctagtagcc 14640 catttccaag cttgataggg tctcttacca gcactcgcac cacccgcccg cgcctgctgg 14700 gcgaggagga gtacctaaac aactcgctgc tgcagccgca gcgcgaaaaa aacctgcctc 14760 cggcatttcc caacaacggg atagagagcc tagtggacaa gatgagtaga tggaagacgt 14820 acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc cacccgtcgt caaaggcacg 14880 accgtcagcg gggtctggtg tgggaggacg atgactcggc agacgacagc agcgtcctgg 14940 atttgggagg gagtggcaac ccgtttgcgc accttcgccc caggctgggg agaatgtttt 15000 aaaaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg gcaccgagcg 15060 ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg aaggtcctcc 15120 tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg gttctccctt 15180 cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta ccggggggag 15240 aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg tgtacctggt 15300 ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca gcaactttct 15360 gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac agaccatcaa 15420 tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata ccaacatgcc 15480 aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg tgtcgcgctt 15540 gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca cgctgcccga 15600 gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg tggagcacta 15660 cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa agtttgacac 15720 ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg gggtatatac 15780 aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg acttcaccca 15840 cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg agggctttag 15900 gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg tggacgccta 15960 ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg gcagcaacag 16020 cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc agccggtgga 16080 ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg aggagaagcg 16140 cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg aggtcgagaa 16200 gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac gcagttacaa 16260 cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg catacaacta 16320 cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg acgtaacctg 16380 cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg tgaccttccg 16440 ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc ccgtgcactc 16500 caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt ttacctctct 16560 gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc cagcccccac 16620 catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc taccgctgcg 16680 caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc gcacctgccc 16740 ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc gcactttttg 16800 agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc tgcgcttccc 16860 aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc gcgtgcgcgg 16920 gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca ccaccgtcga 16980 tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc cgccaccagt 17040 gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct atgctaaaat 17100 gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca ctgccgccca 17160 acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg cggccatgcg 17220 ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca ggcgacgagc 17280 ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg gcaacgtgta 17340 ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc ccccgcgcaa 17400 ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag cggcggcggc 17460 gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg tcatcgcgcc 17520 ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa agctaaagcg 17580 ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg aactgctgca 17640 cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac gtgttttgcg 17700 acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct acaagcgcgt 17760 gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc gcctcgggga 17820 gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg agggcaaccc 17880 aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg caccgtccga 17940 agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc agctgatggt 18000 acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac ctgggctgga 18060 gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg tgcagaccgt 18120 ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag agggcatgga 18180 gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg cggtcgctgc 18240 ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc gcgtttcagc 18300 cccccggcgc ccgcgccgtt cgaggaagta cggcgccgcc agcgcgctac tgcccgaata 18360 tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct accgccccag 18420 aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc gtcgccgtcg 18480 ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag gcaggaccct 18540 ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct ttgtggttct 18600 tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc gaggaagaat 18660 gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc gtgcgcacca 18720 ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc tccttattcc 18780 actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct tgcaggcgca 18840 gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt ctggactctc 18900 acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt gcgtctctgg 18960 ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc accagcaata 19020 tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat ttcggttcca 19080 ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg ctgagggata 19140 agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct ggcattagcg 19200 gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag cttgatcccc 19260 gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag gggcgtggcg 19320 aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac gagcctccct 19380 cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg cccatggcta 19440 ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc gccgacaccc 19500 agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct agccgcgcgt 19560 ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt ggcaactggc 19620 aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc cgacgatgct 19680 tctgaatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc gccagaggag 19740 ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga tgccgcagtg 19800 gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg ggctggtgca 19860 gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa accccacggt 19920 ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc ggttcatccc 19980 tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag ctgtgggtga 20040 taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc tggacagggg 20100 ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca agggtgcccc 20160 aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag aagaagagga 20220 cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc acgtatttgg 20280 gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag gtgtcgaagg 20340 tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag gagaatctca 20400 gtggtacgaa actgaaatta atcatgcagc tgggagagtc cttaaaaaga ctaccccaat 20460 gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc aaggcattct 20520 tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt tctcaactac 20580 tgaggcgacc gcaggcaatg gtgataactt gactcctaaa gtggtattgt acagtgaaga 20640 tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta aggaaggtaa 20700 ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca ttgcttttag 20760 ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg ttctggcggg 20820 ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag agctttcata 20880 ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt ggaatcaggc 20940 tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg aagatgaact 21000 tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta ccaaggtaaa 21060 acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt cagataaaaa 21120 tcaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca acctgtggag 21180 aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt acagtccttc 21240 caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc gagtggtggc 21300 tcccgggtta gtggactgct acattaacct tggagcacgc tggtcccttg actatatgga 21360 caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct caatgttgct 21420 gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct ttgccattaa 21480 aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga aggatgttaa 21540 catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca gcattaagtt 21600 tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg cctccacgct 21660 tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc tctccgccgc 21720 caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca tcccctcccg 21780 caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg aaaccccatc 21840 actgggctcg ggctacgacc cttattacac ctactctggc tctataccct acctagatgg 21900 aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact cttctgtcag 21960 ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc gctcagttga 22020 cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc tggtacaaat 22080 gctagctaac tacaacattg gctaccaggg cttctatatc ccagagagct acaaggaccg 22140 catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg atgatactaa 22200 atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg gatttgttgg 22260 ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc cctatccgct 22320 tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg atcgcaccct 22380 ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag acctgggcca 22440 aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg tggatcccat 22500 ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc gtgtgcaccg 22560 gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg ccggcaacgc 22620 cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc cagtgagcag 22680 gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg cacctatgac 22740 aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt caatacggcc 22800 ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca ctcaaaaaca 22860 tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt ttaccagttt 22920 gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg ctgtataacg 22980 ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg actattctgc 23040 tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca caaccccacc 23100 atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt acagcccacc 23160 ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc ctacttccgc 23220 agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa catgtaaaaa 23280 taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac tctcgggtga 23340 ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt ctgccgcgca 23400 tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct ccacttaaac 23460 tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct gcgcaccatc 23520 accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg gcctccgccc 23580 tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag cgccgggtgg 23640 tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc ctccgcgttg 23700 ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc gtgcccaggc 23760 tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt ctgggcgtta 23820 ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc ctttgcgcct 23880 tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca ggccgcgtcg 23940 tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc ccaccggttc 24000 ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt ttcgctcgtc 24060 acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag acacttaagc 24120 tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg ctcgtgatgc 24180 ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc catcatcgtc 24240 acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc gttcagccag 24300 gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa gttcgccttt 24360 agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat gcccttctcc 24420 cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact ttccgcttcg 24480 ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc gtcttcattc 24540 agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg tgggttgctg 24600 aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac gattacctct 24660 ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt gggcgcaatg 24720 gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac cagcgcgtct 24780 tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt ttttgggggc 24840 gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt tgggggacgt 24900 cgcgccgcac cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc ccgactggcc 24960 atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa ggacagccta 25020 accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc gcctaccacc 25080 ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca ggacccaggt 25140 tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa gcaagaccag 25200 gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca tggcgactac 25260 ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc cattatctgc 25320 gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag ccttgcctac 25380 gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg cacatgcgag 25440 cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct tgccacctat 25500 cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg cagccgagcg 25560 gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc gctcaacgaa 25620 gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa cgctctgcaa 25680 caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga gggtgacaac 25740 gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta cccggcactt 25800 aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg ccgtgcgcag 25860 cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc cgcagttggc 25920 gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga ggagcgacgc 25980 aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca gcggttcttt 26040 gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt tcgacagggc 26100 tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt ctcctacctt 26160 ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct caagggcgag 26220 gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac ctggcagacg 26280 gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct gcagaaactg 26340 ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt ggccgcgcac 26400 ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg tctgccagac 26460 ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg ctcaggaatc 26520 ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta ccgcgaatgc 26580 cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct tgcctaccac 26640 tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg tcgctgcaac 26700 ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga aagtcaaatt 26760 atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc tccggggttg 26820 aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc tgaggactac 26880 cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccaaatgc ggagcttacc 26940 gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa caaagcccgc 27000 caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc cggcgaggag 27060 ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc ccttgcttcc 27120 caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg aggaggaata 27180 ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga tggaagactg 27240 ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa caccgtcacc 27300 ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca gcatggctac 27360 aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc gtagatggga 27420 caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc aagagcaaca 27480 acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg cttgcttgca 27540 agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc acggcgtggc 27600 cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact gcaccggcgg 27660 cagcggcagc ggcagcaaca gcagcggcca cacagaagca aaggcgaccg gatagcaaga 27720 ctctgacaaa gcccaagaaa tccacagcgg cggcagcagc aggaggagga gcgctgcgtc 27780 tggcgcccaa cgaacccgta tcgacccgcg agcttagaaa caggattttt cccactctgt 27840 atgctatatt tcaacagagc aggggccaag aacaagagct gaaaataaaa aacaggtctc 27900 tgcgatccct cacccgcagc tgcctgtatc acaaaagcga agatcagctt cggcgcacgc 27960 tggaagacgc ggaggctctc ttcagtaaat actgcgcgct gactcttaag gactagtttc 28020 gcgccctttc tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca cacccggcgc 28080 cagcacctgt cgtcagcgcc atttcaactt tgtatacaaa agttgtgatg agcaaggaaa 28140 ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct ggagctgccc 28200 aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata tcccgggtca 28260 acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt accaccacac 28320 ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg 28380 ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg actaactcag 28440 gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag ggtataactc 28500 acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg 28560 gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca ttcacgcctc 28620 gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga ggcattggaa 28680 ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc tcgggacctc 28740 ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac tcggcggacg 28800 gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact 28860 gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt gaattgcccg 28920 aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga gagcttgccc 28980 gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac aggggaccct 29040 gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat ctttgttgcc 29100 atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc ctatcgccat 29160 cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt acctggtact 29220 tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt gagtctacga 29280 gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct tacctgccgg 29340 gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg taaaccagac 29400 tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc ttagaaaacc 29460 cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt caagcaactc 29520 tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc tctgtcttgt 29580 gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct gctgtgtgca 29640 catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat gattaggtac 29700 ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa ggtggatttt 29760 aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac cactcttata 29820 aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat tggcaagtat 29880 gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac agttttccag 29940 ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg cgacattacc 30000 atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga aaacactggc 30060 actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac cctactctat 30120 attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta atttactaag 30180 ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca aattcaaaaa 30240 gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct caataccatt 30300 cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg aagtcaggct 30360 tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt tccagtccaa 30420 ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc cgctaccgga 30480 cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg ggataacttg 30540 ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat gtggctcatc 30600 tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat tgtgctacac 30660 ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt ttctcttaca 30720 gtatgattaa atgagacatg attcctcgag tttttatatt actgaccctt gttgcgcttt 30780 tttgtgcgtg ctccacattg gctgcggttt ctcacatcga agtagactgc attccagcct 30840 tcacagtcta tttgctttac ggatttgtca ccctcacgct catctgcagc ctcatcactg 30900 tggtcatcgc ctttatccag tgcattgact gggtctgtgt gcgctttgca tatctcagac 30960 accatcccca gtacagggac aggactatag ctgagcttct tagaattctt taattatgaa 31020 atttactgtg acttttctgc tgattatttg caccctatct gcgttttgtt ccccgacctc 31080 caagcctcaa agacatatat catgcagatt cactcgtata tggaatattc caagttgcta 31140 caatgaaaaa agcgatcttt ccgaagcctg gttatatgca atcatctctg ttatggtgtt 31200 ctgcagtacc atcttagccc tagctatata tccctacctt gacattggct ggaacgcaat 31260 agatgccatg aaccacccaa ctttccccgc gcccgctatg cttccactgc aacaagttgt 31320 tgccggcggc tttgtcccag ccaatcagcc tcgcccacct tctcccaccc ccactgaaat 31380 cagctacttt aatctaacag gaggagatga ctgacaccct agatctagaa atggacggaa 31440 ttattacaga gcagcgcctg ctagaaagac gcagggcagc ggccgagcaa cagcgcatga 31500 atcaagagct ccaagacatg gttaacttgc accagtgcaa aaggggtatc ttttgtctgg 31560 taaagcaggc caaagtcacc tacgacagta ataccaccgg acaccgcctt agctacaagt 31620 tgccaaccaa gcgtcagaaa ttggtggtca tggtgggaga aaagcccatt accataactc 31680 agcactcggt agaaaccgaa ggctgcattc actcaccttg tcaaggacct gaggatctct 31740 gcacccttat taagaccctg tgcggtctca aagatcttat tccctttaac taataaaaaa 31800 aaataataaa gcatcactta cttaaaatca gttagcaaat ttctgtccag tttattcagc 31860 agcacctcct tgccctcctc ccagctctgg tattgcagct tcctcctggc tgcaaacttt 31920 ctccacaatc taaatggaat gtcagtttcc tcctgttcct gtccatccgc acccactatc 31980 ttcatgttgt tgcagatgaa gcgcgcaaga ccgtctgaag ataccttcaa ccccgtgtat 32040 ccatatgaca cggaaaccgg tcctccaact gtgccttttc ttactcctcc ctttgtatcc 32100 cccaatgggt ttcaagagag tccccctggg gtactctctt tgcgcctatc cgaacctcta 32160 gttacctcca atggcatgct tgcgctcaaa atgggcaacg gcctctctct ggacgaggcc 32220 ggcaacctta cctcccaaaa tgtaaccact gtgagcccac ctctcaaaaa aaccaagtca 32280 aacataaacc tggaaatatc tgcacccctc acagttacct cagaagccct aactgtggct 32340 gccgccgcac ctctaatggt cgcgggcaac acactcacca tgcaatcaca ggccccgcta 32400 accgtgcacg actccaaact tagcattgcc acccaaggac ccctcacagt gtcagaagga 32460 aagctagccc tgcaaacatc aggccccctc accaccaccg atagcagtac ccttactatc 32520 actgcctcac cccctctaac tactgccact ggtagcttgg gcattgactt gaaagagccc 32580 atttatacac aaaatggaaa actaggacta aagtacgggg ctcctttgca tgtaacagac 32640 gacctaaaca ctttgaccgt agcaactggt ccaggtgtga ctattaataa tacttccttg 32700 caaactaaag ttactggagc cttgggtttt gattcacaag gcaatatgca acttaatgta 32760 gcaggaggac taaggattga ttctcaaaac agacgcctta tacttgatgt tagttatccg 32820 tttgatgctc aaaaccaact aaatctaaga ctaggacagg gccctctttt tataaactca 32880 gcccacaact tggatattaa ctacaacaaa ggcctttact tgtttacagc ttcaaacaat 32940 tccaaaaagc ttgaggttaa cctaagcact gccaaggggt tgatgtttga cgctacagcc 33000 atagccatta atgcaggaga tgggcttgaa tttggttcac ctaatgcacc aaacacaaat 33060 cccctcaaaa caaaaattgg ccatggccta gaatttgatt caaacaaggc tatggttcct 33120 aaactaggaa ctggccttag ttttgacagc acaggtgcca ttacagtagg aaacaaaaat 33180 aatgataagc taactttatg gactggaata aaccctccac ctaactgtca aattgtggaa 33240 aacactaata caaatgatgg caaacttact ttagtattag taaaaaacgg agggcttgtt 33300 aatggctacg tgtctctagt tggtgtatca gacactgtga accaaatgtt cacacaaaag 33360 acagcaaaca tccaattaag attatatttt gactcttctg gaaatctatt aactgatgaa 33420 tcagacttaa aaattccact taaaaataaa tcttctacag cgaccagtga aactgtagcc 33480 agcagcaaag cctttatgcc aagtactaca gcttatccct tcaacaccac tactagggat 33540 agtgaaaact acattcatgg aatatgttac tacatgacta gttatgatag aagtctattt 33600 cccttgaaca tttctataat gctaaacagc cgtatgattt cttccaatgt tgcctatgcc 33660 atacaatttg aatggaatct aaatgcaagt gaatctccag aaagcaacat agctacgctg 33720 accacatccc cctttttctt ttcttacatt acagaagacg acaactaata aagaatcgtt 33780 tgtgttatgt ttcaacgtgt ttatttttca attgcagaaa atttcaagtc atttttcatt 33840 cagtagtata gccccaccac cacatagctt atacagatca ccgtacctca actttgtata 33900 ataaagttgt aatcaaactc acagaaccct agtattcaac ctgccacctc cctcccaaca 33960 cacagagtac acagtccttt ctccccggct ggccttaaaa agcatcatat catgggtaac 34020 agacatattc ttaggtgtta tattccacac ggtttcctgt cgagccaaac gctcatcagt 34080 gatattaata aactccccgg gcagctcact taagttcatg tcgctgtcca gctgctgagc 34140 cacaggctgc tgtccaactt gcggttgctt aacgggcggc gaaggagaag tccacgccta 34200 catgggggta gagtcataat cgtgcatcag gatagggcgg tggtgctgca gcagcgcgcg 34260 aataaactgc tgccgccgcc gctccgtcct gcaggaatac aacatggcag tggtctcctc 34320 agcgatgatt cgcaccgccc gcagcataag gcgccttgtc ctccgggcac agcagcgcac 34380 cctgatctca cttaaatcag cacagtaact gcagcacagc accacaatat tgttcaaaat 34440 cccacagtgc aaggcgctgt atccaaagct catggcgggg accacagaac ccacgtggcc 34500 atcataccac aagcgcaggt agattaagtg gcgacccctc ataaacacgc tggacataaa 34560 cattacctct tttggcatgt tgtaattcac cacctcccgg taccatataa acctctgatt 34620 aaacatggcg ccatccacca ccatcctaaa ccagctggcc aaaacctgcc cgccggctat 34680 acactgcagg gaaccgggac tggaacaatg acagtggaga gcccaggact cgtaaccatg 34740 gatcatcatg ctcgtcatga tatcaatgtt ggcacaacac aggcacacgt gcatacactt 34800 cctcaggatt acaagctcct cccgcgttag aaccatatcc cagggaacaa cccattcctg 34860 aatcagcgta aatcccacac tgcagggaag acctcgcacg taactcacgt tgtgcattgt 34920 caaagtgtta cattcgggca gcagcggatg atcctccagt atggtagcgc gggtttctgt 34980 ctcaaaagga ggtagacgat ccctactgta cggagtgcgc cgagacaacc gagatcgtgt 35040 tggtcgtagt gtcatgccaa atggaacgcc ggacgtagtc atatttcctg aagcaaaacc 35100 aggtgcgggc gtgacaaaca gatctgcgtc tccggtctcg ccgcttagat cgctctgtgt 35160 agtagttgta gtatatccac tctctcaaag catccaggcg ccccctggct tcgggttcta 35220 tgtaaactcc ttcatgcgcc gctgccctga taacatccac caccgcagaa taagccacac 35280 ccagccaacc tacacattcg ttctgcgagt cacacacggg aggagcggga agagctggaa 35340 gaaccatgtt ttttttttta ttccaaaaga ttatccaaaa cctcaaaatg aagatctatt 35400 aagtgaacgc gctcccctcc ggtggcgtgg tcaaactcta cagccaaaga acagataatg 35460 gcatttgtaa gatgttgcac aatggcttcc aaaaggcaaa cggccctcac gtccaagtgg 35520 acgtaaaggc taaacccttc agggtgaatc tcctctataa acattccagc accttcaacc 35580 atgcccaaat aattctcatc tcgccacctt ctcaatatat ctctaagcaa atcccgaata 35640 ttaagtccgg ccattgtaaa aatctgctcc agagcgccct ccaccttcag cctcaagcag 35700 cgaatcatga ttgcaaaaat tcaggttcct cacagacctg tataagattc aaaagcggaa 35760 cattaacaaa aataccgcga tcccgtaggt cccttcgcag ggccagctga acataatcgt 35820 gcaggtctgc acggaccagc gcggccactt ccccgccagg aaccatgaca aaagaaccca 35880 cactgattat gacacgcata ctcggagcta tgctaaccag cgtagccccg atgtaagctt 35940 gttgcatggg cggcgatata aaatgcaagg tgctgctcaa aaaatcaggc aaagcctcgc 36000 gcaaaaaaga aagcacatcg tagtcatgct catgcagata aaggcaggta agctccggaa 36060 ccaccacaga aaaagacacc atttttctct caaacatgtc tgcgggtttc tgcataaaca 36120 caaaataaaa taacaaaaaa acatttaaac attagaagcc tgtcttacaa caggaaaaac 36180 aacccttata agcataagac ggactacggc catgccggcg tgaccgtaaa aaaactggtc 36240 accgtgatta aaaagcacca ccgacagctc ctcggtcatg tccggagtca taatgtaaga 36300 ctcggtaaac acatcaggtt gattcacatc ggtcagtgct aaaaagcgac cgaaatagcc 36360 cgggggaata catacccgca ggcgtagaga caacattaca gcccccatag gaggtataac 36420 aaaattaata ggagagaaaa acacataaac acctgaaaaa ccctcctgcc taggcaaaat 36480 agcaccctcc cgctccagaa caacatacag cgcttccaca gcggcagcca taacagtcag 36540 ccttaccagt aaaaaagaaa acctattaaa aaaacaccac tcgacacggc accagctcaa 36600 tcagtcacag tgtaaaaaag ggccaagtgc agagcgagta tatataggac taaaaaatga 36660 cgtaacggtt aaagtccaca aaaaacaccc agaaaaccgc acgcgaacct acgcccagaa 36720 acgaaagcca aaaaacccac aacttcctca aatcgtcact tccgttttcc cacgttacgt 36780 cacttcccat tttaagaaaa ctacaattcc caacacatac aagttactcc gccctaaaac 36840 ctacgtcacc cgccccgttc ccacgccccg cgccacgtca caaactccac cccctcatta 36900 tcatattggc ttcaatccaa aataaggtat attattgatg atg 36943 <210> 74 <211> 34674 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO159) <400> 74 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgcctt aatgagtgga aacgcttctt ttaagggggg agtcttcagc ccttatctga 3660 cagggcgtct cccatcctgg gcaggagttc gtcagaatgt tatgggatct actgtggatg 3720 gaagacccgt ccaacccgcc aattcttcaa cgctgaccta tgctacttta agttcttcac 3780 ctttggacgc agctgcagct gccgccgccg cttctgttgc cgctaacact gtgcttggaa 3840 tgggttacta tggaagcatc atggctaatt ccacttcctc taataaccct tctaccctga 3900 ctcaggacaa gttacttgtc cttttggccc agctggaggc tttgacccaa cgtctgggtg 3960 aactttctca gcaggtggtc gagttgcgag tacaaactga gtctgctgtc ggcacggcaa 4020 agtctaaata aaacataaat aaaaaaccag actctgtttg gatttggatc aagcaagtaa 4080 atcaagtgtt tttatttcat ttttcgcgca cggtatgccc tagaccaccg atctctatca 4140 ttgagaactc ggtggatttt ttccaggatc ctatagaggt gggattgaat gtttagatac 4200 atgggcatta ggccgtcttt ggggtggaga tagctccatt gaagggattc atgctccggg 4260 gtagtgttgt aaatcaccca gtcataacaa ggtcgcagtg catggtgttg cacaatatct 4320 tttagaagta ggctgattgc cacagataag cccttggtgt aggtgtttac aaaccggttg 4380 agctgggatg ggtgcattcg gggtgaaatt atgtgcattt tggattggat ttttaagttg 4440 gcaatattgc cgccaagatc ccgtcttggg ttcatgttat gaaggaccac caagacggtg 4500 tatccggtac atttaggaaa tttatcgtgc agcttggatg gaaaagcgtg gaaaaatttg 4560 gagacaccct tgtgtcctcc aagattttcc atgcactcat ccatgataat agcaatgggg 4620 ccgtgggcag cggcgcgggc aaacacgttc cgtgggtctg acacatcata gttatgttcc 4680 tgagttaaat catcataagc cattttaatg aatttggggc ggagagtacc agattggggt 4740 atgaatgttc cttcgggccc cggagcatag ttcccctcac agatttgcat ttcccaagct 4800 ttcagttccg agggtggaat catgtccacc tggggggcta tgaaaaacac cgtttctggg 4860 gcgggggtga ttaattgtga tgatagcaaa tttctgagca attgagattt gccacatccg 4920 gtggggccat aaatgattcc gattacgggt tgcaggtggt agtttaggga acggcaactg 4980 ccgtcttctc gaagcaaggg ggccacctcg ttcatcattt cccttacatg catattttcc 5040 cgcaccaaat ccattaggag gcgctctcct cctagtgata gaagttcttg tagtgaggaa 5100 aagtttttca gcggtttcag accgtcagcc atgggcattt tggagagagt ttgctgcaaa 5160 agttctagtc tgttccacag ttcagtgatg tgttctatgg catctcgatc cagcagacct 5220 cctcgtttcg cgggtttgga cggctcctgg aatagggtat gagacgatgg gcgtccagcg 5280 ctgccagggt tcggtccttc cagggtctca gtgttcgagt cagggttgtt tccgtcacag 5340 tgaaggggtg tgcgcctgct tgggcgcttg ccagggtgcg cttcagactc atcctgctgg 5400 tcgaaaactt ctgtcgcttg gcgccctgta tgtcggccaa gtagcagttt accatgagtt 5460 cgtagttgag cgcctcggct gcgtggcctt tggcgcggag cttacctttg gaagttttct 5520 tgcataccgg gcagtatagg catttcagcg catacaactt gggcgcaagg aaaacggatt 5580 ctggggagta tgcatctgcg ccgcaggagg cgcaaacagt ttcacattcc accagccagg 5640 ttaaatccgg ttcattgggg tcaaaaacaa gttttccgcc atattttttg atgcgtttct 5700 tacctttggt ctccatgagt tcgtgtcctc gttgagtgac aaacaggctg tccgtgtccc 5760 cgtagactga ttttacaggc ctcttctcca gtggagtgcc tcggtcttct tcgtacagga 5820 actctgacca ctctgataca aaggcgcgcg tccaggccag cacaaaggag gctatgtggg 5880 aggggtagcg atcgttgtca accagggggt ccaccttttc caaagtatgc aaacacatgt 5940 caccctcttc aacatccagg aatgtgattg gcttgtaggt gtatttcacg tgacctgggg 6000 tccccgctgg gggggtataa aagggggcgg ttctttgctc ttcctcactg tcttccggat 6060 cgctgtccag gaacgtcagc tgttggggta ggtattccct ctcgaaggcg ggcatgacct 6120 ctgcactcag gttgtcagtt tctaagaacg aggaggattt gatattgaca gtgccggttg 6180 agatgccttt catgaggttt tcgtccattt ggtcagaaaa cacaattttt ttattgtcaa 6240 gtttggtggc aaatgatcca tacagggcgt tggataaaag tttggcaatg gatcgcatgg 6300 tttggttctt ttccttgtcc gcgcgctctt tggcggcgat gttgagttgg acatactcgc 6360 gtgccaggca cttccattcg gggaagatag ttgttaattc atctggcacg attctcactt 6420 gccaccctcg attatgcaag gtaattaaat ccacactggt ggccacctcg cctcgaaggg 6480 gttcattggt ccaacagagc ctacctcctt tcctagaaca gaaaggggga agtgggtcta 6540 gcataagttc atcgggaggg tctgcatcca tggtaaagat tcccggaagt aaatccttat 6600 caaaatagct gatgggagtg gggtcatcta aggccatttg ccattctcga gctgccagtg 6660 cgcgctcata tgggttaagg ggactgcccc atggcatggg atgggtgagt gcagaggcat 6720 acatgccaca gatgtcatag acgtagatgg gatcctcaaa gatgcctatg taggttggat 6780 agcatcgccc ccctctgata cttgctcgca catagtcata tagttcatgt gatggcgcta 6840 gcagccccgg acccaagttg gtgcgattgg gtttttctgt tctgtagacg atctggcgaa 6900 agatggcgtg agaattggaa gagatggtgg gtctttgaaa aatgttgaaa tgggcatgag 6960 gtagacctac agagtctctg acaaagtggg cataagattc ttgaagcttg gttaccagtt 7020 cggcggtgac aagtacgtct agggcgcagt agtcaagtgt ttcttgaatg atgtcataac 7080 ctggttggtt tttcttttcc cacagttcgc ggttgagaag gtattcttcg cgatccttcc 7140 agtactcttc tagcggaaac ccgtctttgt ctgcacggta agatcctagc atgtagaact 7200 gattaactgc cttgtaaggg cagcagccct tctctacggg tagagagtat gcttgagcag 7260 cttttcgtag cgaagcgtga gtaagggcaa aggtgtctct gaccatgact ttgagaaatt 7320 ggtatttgaa gtcgatgtcg tcacaggctc cctgttccca gagttggaag tctacccgtt 7380 tcttgtaggc ggggttgggc aaagcgaaag taacatcatt gaagagaatc ttaccggctc 7440 tgggcataaa attgcgagtg atgcgaaaag gctgtggtac ttccgctcga ttgttgatca 7500 cctgggcagc taggacgatc tcgtcgaaac cgttgatgtt gtgtcctacg atgtataatt 7560 ctatgaaacg cggcgtgcct ctgacgtgag gtagcttact gagctcatca aaggttaggt 7620 ctgtggggtc agataaggcg tagtgttcga gagcccattc gtgcaggtga ggatttgcat 7680 gtaggaatga tgaccaaaga tctaccgcca gtgctgtttg taactggtcc cgatactgac 7740 gaaaatgccg gccaattgcc attttttctg gagtgacaca gtagaaggtt ctggggtctt 7800 gttgccatcg atcccacttg agtttaatgg ctagatcgtg ggccatgttg acgagacgct 7860 cttctcctga gagtttcatg accagcatga aaggaactag ttgtttgcca aaggatccca 7920 tccaggtgta agtttccaca tcgtaggtca ggaagagtct ttctgtgcga ggatgagagc 7980 cgatcgggaa gaactggatt tcctgccacc agttggagga ttggctgttg atgtgatgga 8040 agtagaagtt tctgcggcgc gccgagcatt cgtgtttgtg cttgtacaga cggccgcagt 8100 agtcgcagcg ttgcacgggt tgtatctcgt gaatgagttg tacctggctt cccttgacga 8160 gaaatttcag tgggaagccg aggcctggcg attgtatctc gtgctcttct atattcgctg 8220 tatcggcctg ttcatcttct gtttcgatgg tggtcatgct gacgagcccc cgcgggaggc 8280 aagtccagac ctcggcgcgg gaggggcgga gctgaaggac gagagcgcgc aggctggagc 8340 tgtccagagt cctgagacgc tgcggactca ggttagtagg tagggacaga agattaactt 8400 gcatgatctt ttccagggcg tgcgggaggt tcagatggta cttgatttcc acaggttcgt 8460 ttgtagagac gtcaatggct tgcagggttc cgtgtccttt gggcgccact accgtacctt 8520 tgttttttct tttgatcggt ggtggctctc ttgcttcttg catgctcaga agcggtgacg 8580 gggacgcgcg ccgggcggca gcggttgttc cggacccgag ggcatggctg gtagtggcac 8640 gtcggcgccg cgcacgggca ggttctggta ctgcgctctg agaagacttg cgtgcgccac 8700 cacgcgtcga ttgacgtctt gtatctgacg tctctgggtg aaagctaccg gccccgtgag 8760 cttgaacctg aaagagagtt caacagaatc aatttcggta tcgttaacgg cagcttgtct 8820 cagtatttct tgtacgtcac cagagttgtc ctggtaggcg atctccgcca tgaactgctc 8880 gatttcttcc tcctgaagat ctccgcgacc cgctctttcg acggtggccg cgaggtcatt 8940 ggagatacgg cccatgagtt gggagaatgc attcatgccc gcctcgttcc agacgcggct 9000 gtaaaccacg gccccctcgg agtctcttgc gcgcatcacc acctgagcga ggttaagctc 9060 cacgtgtctg gtgaagaccg catagttgca taggcgctga aaaaggtagt tgagtgtggt 9120 ggcaatgtgt tcggcgacga agaaatacat gatccatcgt ctcagcggca tttcgctaac 9180 atcgcccaga gcttccaagc gctccatggc ctcgtagaag tccacggcaa aattaaaaaa 9240 ctgggagttt cgcgcggaca cggtcaattc ctcctcgaga agacggatga gttcggctat 9300 ggtggcccgt acttcgcgtt cgaaggctcc cgggatctct tcttcctctt ctatctcttc 9360 ttccactaac atctcttctt cgtcttcagg cgggggcgga gggggcacgc ggcgacgtcg 9420 acggcgcacg ggcaaacggt cgatgaatcg ttcaatgacc tctccgcggc ggcggcgcat 9480 ggtttcagtg acggcgcggc cgttctcgcg cggtcgcaga gtaaaaacac cgccgcgcat 9540 ctccttaaag tggtgactgg gaggttctcc gtttgggagg gagagggcgc tgattataca 9600 ttttattaat tggcccgtag ggactgcacg cagagatctg atcgtgtcaa gatccacggg 9660 atctgaaaac ctttcgacga aagcgtctaa ccagtcacag tcacaaggta ggctgagtac 9720 ggcttcttgt gggcgggggt ggttatgtgt tcggtctggg tcttctgttt cttcttcatc 9780 tcgggaaggt gagacgatgc tgctggtgat gaaattaaag taggcagttc taagacggcg 9840 gatggtggcg aggagcacca ggtctttggg tccggcttgc tggatacgca ggcgattggc 9900 cattccccaa gcattatcct gacatctagc aagatctttg tagtagtctt gcatgagccg 9960 ttctacgggc acttcttcct cacccgttct gccatgcata cgtgtgagtc caaatccgcg 10020 cattggttgt accagtgcca agtcagctac gactctttcg gcgaggatgg cttgctgtac 10080 ttgggtaagg gtggcttgaa agtcatcaaa atccacaaag cggtggtaag ctcctgtatt 10140 aatggtgtaa gcacagttgg ccatgactga ccagttaact gtctggtgac cagggcgcac 10200 gagctcggtg tatttaaggc gcgaataggc gcgggtgtca aagatgtaat cgttgcaggt 10260 gcgcaccaga tactggtacc ctataagaaa atgcggcggt ggttggcggt agagaggcca 10320 tcgttctgta gctggagcgc caggggcgag gtcttccaac ataaggcggt gatagccgta 10380 gatgtacctg gacatccagg tgattcctgc ggcggtagta gaagcccgag gaaactcgcg 10440 tacgcggttc caaatgttgc gtagcggcat gaagtagttc attgtaggca cggtttgacc 10500 agtgaggcgc gcgcagtcat tgatgctcta tagacacgga gaaaatgaaa gcgttcagcg 10560 actcgactcc gtagcctgga ggaacgtgaa cgggttgggt cgcggtgtac cccggttcga 10620 gacttgtact cgagccggcc ggagccgcgg ctaacgtggt attggcactc ccgtctcgac 10680 ccagcctaca aaaatccagg atacggaatc gagtcgtttt gctggtttcc gaatggcagg 10740 gaagtgagtc ctattttttt tttttgccgc tcagatgcat cccgtgctgc gacagatgcg 10800 cccccaacaa cagcccccct cgcagcagca gcagcagcaa tcacaaaagg ctgtccctgc 10860 aactactgca actgccgccg tgagcggtgc gggacagccc gcctatgatc tggacttgga 10920 agagggcgaa ggactggcac gtctaggtgc gccttcaccc gagcggcatc cgcgagttca 10980 actgaaaaaa gattctcgcg aggcgtatgt gccccaacag aacctattta gagacagaag 11040 cggcgaggag ccggaggaga tgcgagcttc ccgctttaac gcgggtcgtg agctgcgtca 11100 cggtttggac cgaagacgag tgttgcggga cgaggatttc gaagttgatg aaatgacagg 11160 gatcagtcct gccagggcac acgtggctgc agccaacctt gtatcggctt acgagcagac 11220 agtaaaggaa gagcgtaact tccaaaagtc ttttaataat catgtgcgaa ccctgattgc 11280 ccgcgaagaa gttacccttg gtttgatgca tttgtgggat ttgatggaag ctatcattca 11340 gaaccctact agcaaacctc tgaccgccca gctgtttctg gtggtgcaac acagcagaga 11400 caatgaggct ttcagagagg cgctgctgaa catcaccgaa cccgagggga gatggttgta 11460 tgatcttatc aacattctac agagtatcat agtgcaggag cggagcctgg gcctggccga 11520 gaaggtggct gccatcaatt actcggtttt gagcttggga aaatattacg ctcgcaaaat 11580 ctacaagact ccatacgttc ccatagacaa ggaggtgaag atagatgggt tctacatgcg 11640 catgacgctc aaggtcttga ccctgagcga tgatcttggg gtgtatcgca atgacagaat 11700 gcatcgcgcg gttagcgcca gcaggaggcg cgagttaagc gacagggaac tgatgcacag 11760 tttgcaaaga gctctgactg gagctggaac cgagggtgag aattacttcg acatgggagc 11820 tgacttgcag tggcagccta gtcgcagggc tctgagcgcc gcgacggcag gatgtgagct 11880 tccttacata gaagaggcgg atgaaggcga ggaggaagag ggcgagtact tggaagactg 11940 atggcacaac ccgtgttttt tgctagatgg aacagcaagc accggatccc gcaatgcggg 12000 cggcgctgca gagccagccg tccggcatta actcctcgga cgattggacc caggccatgc 12060 aacgtatcat ggcgttgacg actcgcaacc ccgaagcctt tagacagcaa ccccaggcca 12120 accgtctatc ggccatcatg gaagctgtag tgccttcccg ctctaatccc actcatgaga 12180 aggtcctggc catcgtgaac gcgttggtgg agaacaaagc tattcgtcca gatgaggccg 12240 gactggtata caacgctctc ttagaacgcg tggctcgcta caacagtagc aatgtgcaaa 12300 ccaatttgga ccgtatgata acagatgtac gcgaagccgt gtctcagcgc gaaaggttcc 12360 agcgtgatgc caacctgggt tcgctggtgg cgttaaatgc tttcttgagt actcagcctg 12420 ctaatgtgcc gcgtggtcaa caggattata ctaacttttt aagcgctttg agactgatgg 12480 tatcagaagt acctcagagc gaagtgtatc agtccggtcc tgattacttc tttcagacta 12540 gcagacaggg cttgcagacg gtaaatctga gccaagcttt taaaaacctt aaaggtttgt 12600 ggggagtgca tgccccggta ggagaaagag caaccgtgtc tagcttgtta actccgaact 12660 cccgcctatt attactgttg gtagctcctt tcaccgacag cggtagcatc gaccgtaatt 12720 cctatttggg ttacctacta aacctgtatc gcgaagccat agggcaaagt caggtggacg 12780 agcagaccta tcaagaaatt acccaagtca gtcgcgcttt gggacaggaa gacactggca 12840 gtttggaagc cactctgaac ttcttgctta ccaatcggtc tcaaaagatc cctcctcaat 12900 atgctcttac tgcggaggag gagaggatcc ttagatatgt gcagcagagc gtgggattgt 12960 ttctgatgca agagggggca actccgactg cagcactgga catgacagcg cgaaatatgg 13020 agcccagcat gtatgccagt aaccgacctt tcattaacaa actgctggac tacttgcaca 13080 gagctgccgc tatgaactct gattatttca ccaatgccat cttaaacccg cactggctgc 13140 ccccacctgg tttctacacg ggcgaatatg acatgcccga ccctaatgac ggatttctgt 13200 gggacgacgt ggacagcgat gttttttcac ctctttctga tcatcgcacg tggaaaaagg 13260 aaggcggcga tagaatgcat tcttctgcat cgctgtccgg ggtcatgggt gctaccgcgg 13320 ctgagcccga gtctgcaagt ccttttccta gtctaccctt ttctctacac agtgtacgta 13380 gcagcgaagt gggtagaata agtcgcccga gtttaatggg cgaagaggag tatctaaacg 13440 attccttgct cagaccggca agagaaaaaa atttcccaaa caatggaata gaaagtttgg 13500 tggataaaat gagtagatgg aagacttatg ctcaggatca cagagacgag cctgggatca 13560 tggggattac aagtagagcg agccgtagac gccagcgcca tgacagacag aggggtcttg 13620 tgtgggacga tgaggattcg gccgatgata gcagcgtgct ggacttgggt gggagaggaa 13680 ggggcaaccc gtttgctcat ttgcgccctc gcttgggtgg tatgttgtaa aaaaaaataa 13740 aaaaaaaact caccaaggcc atggcgacga gcgtacgttc gttcttcttt attatctgtg 13800 tctagtataa tgaggcgagt cgtgctaggc ggagcggtgg tgtatccgga gggtcctcct 13860 ccttcgtacg agagcgtgat gcagcagcag caggcgacgg cggtgatgca atccccactg 13920 gaggctccct ttgtgcctcc gcgatacctg gcacctacgg agggcagaaa cagcattcgt 13980 tattcggaac tggcacctca gtacgatacc accaggttgt atctggtgga caacaagtcg 14040 gcggacattg cttctctgaa ctatcagaat gaccacagca acttcttgac cacggtggtg 14100 caaaacaatg actttacccc tacggaagcc agcacccaga ccattaactt tgatgaacga 14160 tcgcggtggg gcggtcagct aaagaccatc atgcatacta acatgccaaa cgtgaacgag 14220 tatatgttta gtaacaagtt caaagcgcgt gtgatggtgt ccagaaaacc tcccgacggt 14280 gctgcagttg gggatactta tgatcacaag caggatattt tgaaatatga gtggttcgag 14340 tttactttgc cagaaggcaa cttttcagtt actatgacta ttgatttgat gaacaatgcc 14400 atcatagata attacttgaa agtgggtaga cagaatggag tgcttgaaag tgacattggt 14460 gttaagttcg acaccaggaa cttcaagctg ggatgggatc ccgaaaccaa gttgatcatg 14520 cctggagtgt atacgtatga agccttccat cctgacattg tcttactgcc tggctgcgga 14580 gtggatttta ccgagagtcg tttgagcaac cttcttggta tcagaaaaaa acagccattt 14640 caagagggtt ttaagatttt gtatgaagat ttagaaggtg gtaatattcc ggccctcttg 14700 gatgtagatg cctatgagaa cagtaagaaa gaacaaaaag ccaaaataga agctgctaca 14760 gctgctgcag aagctaaggc aaacatagtt gccagcgact ctacaagggt tgctaacgct 14820 ggagaggtca gaggagacaa ttttgcgcca acacctgttc cgactgcaga atcattattg 14880 gccgatgtgt ctgaaggaac ggacgtgaaa ctcactattc aacctgtaga aaaagatagt 14940 aagaatagaa gctataatgt gttggaagac aaaatcaaca cagcctatcg cagttggtat 15000 ctttcgtaca attatggcga tcccgaaaaa ggagtgcgtt cctggacatt gctcaccacc 15060 tcagatgtca cctgcggagc agagcaggtc tactggtcgc ttccagacat gatgaaggat 15120 cctgtcactt tccgctccac tagacaagtc agtaactacc ctgtggtggg tgcagagctt 15180 atgcccgtct tctcaaagag cttctacaac gaacaagctg tgtactccca gcagctccgc 15240 cagtccacct cgcttacgca cgtcttcaac cgctttcctg agaaccagat tttaatccgt 15300 ccgccggcgc ccaccattac caccgtcagt gaaaacgttc ctgctctcac agatcacggg 15360 accctgccgt tgcgcagcag tatccgggga gtccaacgtg tgaccgttac tgacgccaga 15420 cgccgcacct gtccctacgt gtacaaggca ctgggcatag tcgcaccgcg cgtcctttca 15480 agccgcactt tctaaaaaaa aaaaaaatgt ccattcttat ctcgcccagt aataacaccg 15540 gttggggtct gcgcgctcca agcaagatgt acggaggcgc acgcaaacgt tctacccaac 15600 atcctgtccg tgttcgcgga cattttcgcg ctccatgggg cgccctcaag ggccgcactc 15660 gcgttcgaac caccgtcgat gatgtaatcg atcaggtggt tgccgacgcc cgtaattata 15720 ctcctactgc gcctacatct actgtggatg cagttattga cagtgtagtg gctgacgctc 15780 gcaactatgc tcgacgtaag agccggcgaa ggcgcattgc cagacgccac cgagctacca 15840 ctgccatgcg agccgcaaga gctctgctac gaagagctag acgcgtgggg cgaagagcca 15900 tgcttagggc ggccagacgt gcagcttcgg gcgccagcgc cggcaggtcc cgcaggcaag 15960 cagccgctgt cgcagcggcg actattgccg acatggccca atcgcgaaga ggcaatgtat 16020 actgggtgcg tgacgctgcc accggtcaac gtgtacccgt gcgcacccgt ccccctcgca 16080 cttagaagat actgagcagt ctccgatgtt gtgtcccagc ggcgaggatg tccaagcgca 16140 aatacaagga agaaatgctg caggttatcg cacctgaagt ctacggccaa ccgttgaagg 16200 atgaaaaaaa accccgcaaa atcaagcggg ttaaaaagga caaaaaagaa gaggaagatg 16260 gcgatgatgg gctggcggag tttgtgcgcg agtttgcccc acggcgacgc gtgcaatggc 16320 gtgggcgcaa agttcgacat gtgttgagac ctggaacttc ggtggtcttt acacccggcg 16380 agcgttcaag cgctactttt aagcgttcct atgatgaggt gtacggggat gatgatattc 16440 ttgagcaggc ggctgaccga ttaggcgagt ttgcttatgg caagcgtagt agaataactt 16500 ccaaggatga gacagtgtcg atacccttgg atcatggaaa tcccacccct agtcttaaac 16560 cggtcacttt gcagcaagtg ttacccgtaa ctccgcgaac aggtgttaaa cgcgaaggtg 16620 aagatttgta tcccactatg caactgatgg tacccaaacg ccagaagttg gaggacgttt 16680 tggagaaagt aaaagtggat ccagatattc aacctgaggt taaagtgaga cccattaagc 16740 aggtagcgcc tggtctgggg gtacaaactg tagacattaa gattcccact gaaagtatgg 16800 aagtgcaaac tgaacccgca aagcctactg ccacctccac tgaagtgcaa acggatccat 16860 ggatgcccat gcctattaca actgacgccg ccggtcccac tcgaagatcc cgacgaaagt 16920 acggtccagc aagtctgttg atgcccaatt atgttgtaca cccatctatt attcctactc 16980 ctggttaccg aggcactcgc tactatcgca gccgaaacag tacctcccgc cgtcgccgca 17040 agacacctgc aaatcgcagt cgtcgccgta gacgcacaag caaaccgact cccggcgccc 17100 tggtgcggca agtgtaccgc aatggtagtg cggaaccttt gacactgccg cgtgcgcgtt 17160 accatccgag tatcatcact taatcaatgt tgccgctgcc tccttgcaga tatggccctc 17220 acttgtcgcc ttcgcgttcc catcactggt taccgaggaa gaaactcgcg ccgtagaaga 17280 gggatgttgg gacgcggaat gcgacgctac aggcgacggc gtgctatccg caagcaattg 17340 cggggtggtt ttttaccagc cttaattcca attatcgctg ctgcaattgg cgcgatacca 17400 ggcatagctt ccgtggcggt tcaggcctcg caacgacatt gacattggaa aaaaacgtat 17460 aaataaaaaa aaaaaaatac aatggactct gacactcctg gtcctgtgac tatgttttct 17520 tagagatgga agacatcaat ttttcatcct tggctccgcg acacggcacg aagccgtaca 17580 tgggcacctg gagcgacatc ggcacgagcc aactgaacgg gggcgccttc aattggagca 17640 gtatctggag cgggcttaaa aattttggct caaccataaa aacatacggg aacaaagctt 17700 ggaacagcag tacaggacag gcgcttagaa ataaacttaa agaccagaac ttccaacaaa 17760 aagtagtcga tgggatagct tccggcatca atggagtggt agatttggct aaccaggctg 17820 tgcagaaaaa gataaacagt cgtttggacc cgccgccagc aaccccaggt gaaatgcaag 17880 tggaggaaga aattcctccg ccagaaaaac gaggcgacaa gcgtccgcgt cccgatttgg 17940 aagagacgct ggtgacgcgc gtagatgaac cgccttctta tgaggaagca acgaagcttg 18000 gaatgcccac cactagaccg atagccccaa tggccaccgg ggtgatgaaa ccttctcagt 18060 tgcatcgacc cgtcaccttg gatttgcccc ctccccctgc tgctactgct gtacccgctt 18120 ctaagcctgt cgctgccccg aaaccagtcg ccgtagccag gtcacgtccc gggggcgctc 18180 ctcgtccaaa tgcgcactgg caaaatactc tgaacagcat cgtgggtcta ggcgtgcaaa 18240 gtgtaaaacg ccgtcgctgc ttttaattaa atatggagta gcgcttaact tgcctatctg 18300 tgtatatgtg tcattacacg ccgtcacagc agcagaggaa aaaaggaaga ggagcagagg 18360 aaaaaaggaa gaggtcgtgc gtcgacgctg agttactttc aagatggcca ccccatcgat 18420 gctgccccaa tgggcataca tgcacatcgc cggacaggat gcttcggagt acctgagtcc 18480 gggtctggtg cagttcgccc gcgccacaga cacctacttc aatctgggaa ataagtttag 18540 aaatcccacc gtagcgccga cccacgatgt gaccaccgac cgtagccagc ggctcatgtt 18600 gcgcttcgtg cccgttgacc gggaggacaa tacatactct tacaaagtgc ggtacaccct 18660 ggccgtgggc gacaacagag tgctggatat ggccagcacg ttctttgaca ttaggggtgt 18720 gttggacaga ggtcccagtt tcaaacccta ttctggtacg gcttacaact ccctggctcc 18780 taaaggcgct ccaaatacat ctcagtggat tgcagaaggt gtaaaaaata caactggtga 18840 ggaacacgta acagaagagg aaaccaatac tactacttac acttttggca atgctcctgt 18900 aaaagctgaa gctgaaatta caaaagaagg actcccagta ggtttggaag tttcagatga 18960 agaaagtaaa ccgatttatg ctgataaaac atatcagcca gaacctcagc tgggagatga 19020 aacttggact gaccttgatg gaaaaaccga aaagtatgga ggcagggctc tcaaacccga 19080 tactaagatg aaaccatgct acgggtcctt tgccaaacct actaatgtga aaggcggtca 19140 ggcaaaacaa aaaacaacgg agcagccaaa tcagaaagtc gaatatgata tcgacatgga 19200 gttttttgat gcggcatcgc agaaaacaaa cttaagtcct aaaattgtca tgtatgcaga 19260 aaatgtaaat ttggaaactc cagacactca tgtagtgtac aaacctggaa cagaagacac 19320 aagttccgaa gctaatttgg gacaacaatc tatgcccaac agacccaact acattggctt 19380 cagagataac tttattggac ttatgtacta taacagtact ggtaacatgg gggtgctggc 19440 tggtcaagcg tctcagttaa atgcagtggt tgacttgcag gacagaaaca cagaactttc 19500 ttaccaactc ttgcttgact ctctgggcga cagaaccaga tactttagca tgtggaatca 19560 ggctgtggac agttatgatc ctgatgtacg tgttattgaa aatcatggtg tggaagatga 19620 acttcccaac tactgttttc cactggacgg cataggtgtt ccaacaacca gttacaaatc 19680 aatagttcca aatggagaca atgcgcctaa ttggaaggaa cctgaagtaa atggaacaag 19740 tgagatcgga cagggtaatt tgtttgccat ggaaattaac cttcaagcca atctatggcg 19800 aagtttcctt tattccaatg tggctctata tctcccagac tcgtacaaat acaccccgtc 19860 caatgtcact cttccagaaa acaaaaacac ctacgactac atgaacgggc gggtggtgcc 19920 gccatctcta gtagacacct atgtgaacat tggtgccagg tggtctctgg atgccatgga 19980 caatgtcaac ccattcaacc accaccgtaa cgctggcttg cgttaccgat ccatgcttct 20040 gggtaacgga cgttatgtgc ctttccacat acaagtgcct caaaaattct tcgctgttaa 20100 aaacctgctg cttctcccag gctcctacac ttatgagtgg aactttagga aggatgtgaa 20160 catggttcta cagagttccc tcggtaacga cctgcgggta gatggcgcca gcatcagttt 20220 cacgagcatc aacctctatg ctactttttt ccccatggct cacaacaccg cttccaccct 20280 tgaagccatg ctgcggaatg acaccaatga tcagtcattc aacgactacc tatctgcagc 20340 taacatgctc taccccattc ctgccaatgc aaccaatatt cccatttcca ttccttctcg 20400 caactgggcg gctttcagag gctggtcatt taccagactg aaaaccaaag aaactccctc 20460 tttggggtct ggatttgacc cctactttgt ctattctggt tctattccct acctggatgg 20520 taccttctac ctgaaccaca cttttaagaa ggtttccatc atgtttgact cttcagtgag 20580 ctggcctgga aatgacaggt tactatctcc taacgaattt gaaataaagc gcactgtgga 20640 tggcgaaggc tacaacgtag cccaatgcaa catgaccaaa gactggttct tggtacagat 20700 gctcgccaac tacaacatcg gctatcaggg cttctacatt ccagaaggat acaaagatcg 20760 catgtattca tttttcagaa acttccagcc catgagcagg caggtggttg atgaggtcaa 20820 ttacaaagac ttcaaggccg tcgccatacc ctaccaacac aacaactctg gctttgtggg 20880 ttacatggct ccgaccatgc gccaaggtca accctatccc gctaactatc cctatccact 20940 cattggaaca actgccgtaa atagtgttac gcagaaaaag ttcttgtgtg acagaaccat 21000 gtggcgcata ccgttctcga gcaacttcat gtctatgggg gcccttacag acttgggaca 21060 gaatatgctc tatgccaact cagctcatgc tctggacatg acctttgagg tggatcccat 21120 ggatgagccc accctgcttt atcttctctt cgaagttttc gacgtggtca gagtgcatca 21180 gccacaccgc ggcatcatcg aggcagtcta cctgcgtaca ccgttctcgg ccggtaacgc 21240 taccacgtaa gaagcttctt gcttcttgca aatagcagct gcaaccatgg cctgcggatc 21300 ccaaaacggc tccagcgagc aagagctcag agccattgtc caagacctgg gttgcggacc 21360 ctattttttg ggaacctacg ataagcgctt cccggggttc atggcccccg ataagctcgc 21420 ctgtgccatt gtaaatacgg ccggacgtga gacgggggga gagcactggt tggctttcgg 21480 ttggaaccca cgttctaaca cctgctacct ttttgatcct tttggattct cggatgatcg 21540 tctcaaacag atttaccagt ttgaatatga gggtctcctg cgccgcagcg ctcttgctac 21600 caaggaccgc tgtattacgc tggaaaaatc tacccagacc gtgcagggtc cccgttctgc 21660 cgcctgcgga cttttctgct gcatgttcct tcacgccttt gtgcactggc ctgaccgtcc 21720 catggacgga aaccccacca tgaaattgct aactggagtg ccaaacaaca tgcttcattc 21780 tcctaaagtc cagcccaccc tgtgtgacaa tcaaaaagca ctctaccatt ttcttaatac 21840 ccattcgcct tattttcgct cccatcgtac acacatcgaa agggccactg cgttcgaccg 21900 tatggatgtt caataatgac tcatgtaaac aacgtgttca ataaacatca ctttattttt 21960 ttacatgtat caaggctctg cattacttat ttatttacaa gtcgaatggg ttctgacgag 22020 aatcagaatg acccgcaggc agtgatacgt tgcggaactg atacttgggt tgccacttga 22080 attcgggaat caccaacttg ggaaccggta tatcgggcag gatgtcactc cacagctttc 22140 tggtcagctg caaagctcca agcaggtcag gagccgaaat cttgaaatca caattaggac 22200 cagtgctttg agcgcgagag ttgcggtaca ccggattgca gcactgaaac accatcagcg 22260 acggatgtct cacgcttgcc agcacggtgg gatctgcaat catgcccaca tccagatctt 22320 cagcattggc aatgctgaac ggggtcatct tgcaggtctg cctacccatg gcgggcaccc 22380 aattaggctt gtggttgcaa tcgcagtgca gggggatcag tatcatcttg gcctgatcct 22440 gtctgattcc tggatacacg gctctcatga aagcatcata ttgcttgaaa gcctgctggg 22500 ctttactacc ctcggtataa aacatcccgc aggacctgct cgaaaactgg ttagctgcac 22560 agccggcatc attcacacag cagcgggcgt cattgttagc tatttgcacc acacttctgc 22620 cccagcggtt ttgggtgatt ttggttcgct cgggattctc ctttaaggct cgttgtccgt 22680 tctcgctggc cacatccatc tcgataatct gctccttctg aatcataata ttgccatgca 22740 ggcacttcag cttgccctca taatcattgc agccatgagg ccacaacgca cagcctgtac 22800 attcccaatt atggtgggcg atctgagaaa aagaatgtat cattccctgc agaaatcttc 22860 ccatcatcgt gctcagtgtc ttgtgactag tgaaagttaa ctggatgcct cggtgctcct 22920 cgtttacgta ctggtgacag atgcgcttgt attgttcgtg ttgctcaggc attagtttaa 22980 aagaggttct aagttcgtta tccagcctgt acttctccat cagcagacac atcacttcca 23040 tgcctttctc ccaagcagac accaggggca agctaatcgg attcttaaca gtgcaggcag 23100 cagctccttt agccagaggg tcatctttag cgatcttctc aatgcttctt ttgccatcct 23160 tctcaacgat gcgcacgggc gggtagctga aacccactgc tacaagttgc gcctcttctc 23220 tttcttcttc gctgtcttga ctgatgtctt gcatggggat atgtttggtc ttccttggct 23280 tctttttggg gggtatcgga ggaggaggac tgtcgctccg ttccggagac agggaggatt 23340 gtgacgtttc gctcaccatt accaactgac tgtcggtaga agaacctgac cccacacggc 23400 gacaggtgtt tctcttcggg ggcagaggtg gaggcgattg cgaagggctg cggtccgacc 23460 tggaaggcgg atgactggca gaaccccttc cgcgttcggg ggtgtgctcc ctgtggcggt 23520 cgcttaactg atttccttcg cggctggcca ttgtgttctc ctaggcagag aaacaacaga 23580 catggaaact cagccattgc tgtcaacatc gccacgagtg ccatcacatc tcgtcctcag 23640 cgacgaggaa aaggagcaga gcttaagcat tccaccgccc agtcctgcca ccacctctac 23700 cctagaagat aaggaggtcg acgcatctca tgacatgcag aataaaaaag cgaaagagtc 23760 tgagacagac atcgagcaag acccgggcta tgtgacaccg gtggaacacg aggaagagtt 23820 gaaacgcttt ctagagagag aggatgaaaa ctgcccaaaa caacgagcag ataactatca 23880 ccaagatgct ggaaataggg atcagaacac cgactacctc atagggcttg acggggaaga 23940 cgcgctcctt aaacatctag caagacagtc gctcatagtc aaggatgcat tattggacag 24000 aactgaagtg cccatcagtg tggaagagct cagccgcgcc tacgagctta acctcttttc 24060 acctcgtact ccccccaaac gtcagccaaa cggcacctgc gagccaaatc ctcgcttaaa 24120 cttttatcca gcttttgctg tgccagaagt actggctacc tatcacatct tttttaaaaa 24180 tcaaaaaatt ccagtctcct gccgcgctaa tcgcacccgc gccgatgccc tactcaatct 24240 gggacctggt tcacgcttac ctgatatagc ttccttggaa gaggttccaa agatcttcga 24300 gggtctgggc aataatgaga ctcgggccgc aaatgctctg caaaagggag aaaatggcat 24360 ggatgagcat cacagcgttc tggtggaatt ggaaggcgat aatgccagac tcgcagtact 24420 caagcgaagc atcgaggtca cacacttcgc atatcccgct gtcaacctgc cccctaaagt 24480 catgacggcg gtcatggacc agttactcat taagcgcgca agtccccttt cagaagacat 24540 gcatgaccca gatgcctgtg atgagggtaa accagtggtc agtgatgagc agctaacccg 24600 atggctgggc accgactctc ccagggattt ggaagagcgt cgcaagctta tgatggccgt 24660 ggtgctggtt accgtagaac tagagtgtct ccgacgtttc tttaccgatt cagaaacctt 24720 gcgcaaactc gaagagaatc tgcactacac ttttagacac ggctttgtgc ggcaggcatg 24780 caagatatct aacgtggaac tcaccaacct ggtttcctac atgggtattc tgcatgagaa 24840 tcgcctagga caaagcgtgc tgcacagcac cctgaagggg gaagcccgcc gtgattacat 24900 ccgcgattgt gtctatctgt acctgtgcca cacgtggcaa accggcatgg gtgtatggca 24960 gcaatgttta gaagaacaga acttgaaaga gcttgacaag ctcttacaga aatctcttaa 25020 ggttctgtgg acagggttcg acgagcgcac cgtcgcttcc gacctggcag acctcatctt 25080 cccagagcgt ctcagggtta ctttgcgaaa cggattgcct gactttatga gccagagcat 25140 gcttaacaat tttcgctctt tcatcctgga acgctccggt atcctgcccg ccacctgctg 25200 cgcactgccc tccgactttg tgcctctcac ctaccgcgag tgccccccgc cgctatggag 25260 tcactgctac ctgttccgtc tggccaacta tctctcctac cactcggatg tgatcgagga 25320 tgtgagcgga gacggcttgc tggagtgtca ctgccgctgc aatctgtgca cgccccaccg 25380 gtccctagct tgcaaccccc agttgatgag cgaaacccag ataataggca cctttgaatt 25440 gcaaggcccc agcagccaag gcgatgggtc ttctcctggg caaagtttaa aactgacccc 25500 gggactgtgg acctccgcct acttgcgcaa gtttgctccg gaagattacc acccctatga 25560 aatcaagttc tatgaggacc aatcacagcc tccaaaggcc gaactttcgg cctgcgtcat 25620 cacccagggg gcaattctgg cccaattgca agccatccaa aaatcccgcc aagaatttct 25680 actgaaaaag ggtaaggggg tctaccttga cccccagacc ggcgaggaac tcaacacaag 25740 gttccctcag gatgtcccaa cgacgagaaa acaagaagtt gaaggtgcag ccgccgcccc 25800 cagaagatat ggaggaagat tgggacagtc aggcagagga ggcggaggag gacagtctgg 25860 aggacagtct ggaggaagac agtttggagg aggaaaacga ggaggcagag gaggtggaag 25920 aagtaaccgc cgacaaacag ttatcctcgg ctgcggagac aagcaacagc gctaccatct 25980 ccgctccgag tcgaggaacc cggcggcgtc ccagcagtag atgggacgag accggacgct 26040 tcccgaaccc aaccagcgct tccaagaccg gtaagaagga tcggcaggga tacaagtcct 26100 ggcgggggca taagaatgcc atcatctcct gcttgcatga gtgcgggggc aacatatcct 26160 tcacgcggcg ctacttgcta ttccaccatg gggtgaactt tccgcgcaat gttttgcatt 26220 actaccgtca cctccacagc ccctactata gccagcaaat cccggcagtc tcgacagata 26280 aagacagcgg cggcgacctc caacagaaaa ccagcagcgg cagttagaaa atacacaaca 26340 agtgcagcaa caggaggatt aaagattaca gccaacgagc cagcgcaaac ccgagagtta 26400 agaaatcgga tctttccaac cctgtatgcc atcttccagc agagtcgggg tcaagagcag 26460 gaactgaaaa taaaaaaccg atctctgcgt tcgctcacca gaagttgttt gtatcacaag 26520 agcgaagatc aacttcagcg cactctcgag gacgccgagg ctctcttcaa caagtactgc 26580 gcgctgactc ttaaagagta ggcagcgacc gcgcttattc aaaaaaggcg ggaattacat 26640 catcctcgac atgagtaaag aaattcccac gccttacatg tggagttatc aaccccaaat 26700 gggattggcg gcaggcgcct cccaggacta ctccacccgc atgaattggc tcagcgccgg 26760 gccttctatg atttctcgag ttaatgatat acgcgcctac cgaaaccaaa tacttttgga 26820 acagtcagct cttaccacca cgccccgcca acaccttaat cccagaaatt ggcccgccgc 26880 cctagtgtac caggaaagtc ccgctcccac cactgtatta cttcctcgag acgcccaggc 26940 cgaagtccaa atgactaatg caggtgcgca gttagctggc ggctccaccc tatgtcgtca 27000 caggcctcgg cataatataa aacgcctgat gatcagaggc cgaggtatcc agctcaacga 27060 cgagtcggtg agctctccgc ttggtctacg accagacgga atctttcaga ttgccggctg 27120 cgggagatct tccttcaccc ctcgtcaggc tgttctgact ttggaaagtt cgtcttcgca 27180 accccgctcg ggcggaatcg ggaccgttca atttgtggag gagtttactc cctctgtcta 27240 cttcaacccc ttctccggat ctcctgggca ttacccggac gagttcatac cgaacttcga 27300 cgcgattagc gagtcagtgg acggctacga ttgaggatgt taagtggaga ggcagagcaa 27360 ctgcgcctga aacacctggt ccactgtcgc cgccacaagt gctttgcccg cgactccggt 27420 gagttttgct actttgaatt gcccgaggat catatcgagg gcccggcgca cggcgtccgg 27480 cttaccgccc agggagagct tgcccgtagc ctgattcggg agtttaccca gcgccccctg 27540 ctagttgagc gggacagggg accctgtgtt ctcactgtga tttgcaactg tcctaaccct 27600 ggattacatc aagatctttg ttgccatctc tgtgctgagt ataataaata cagaaattaa 27660 aatatactgg ggctcctatc gccatcctgt aaacgccacc gtcttcaccc gcccaagcaa 27720 accaaggcga accttacctg gtacttttaa catctctccc tctgtgattt acaacagttt 27780 caacccagac ggagtgagtc tacgagagaa cctctccgag ctcagctact ccatcagaaa 27840 aaacaccacc ctccttacct gccgggaacg tacgagtgcg tcaccggccg ctgcaccaca 27900 cctaccgcct gaccgtaaac cagacttttt ccggacagac ctcaataact ctgtttacca 27960 gaacaggagg tgagcttaga aaacccttag ggtattaggc caaaggcgca gctactgtgg 28020 ggtttatgaa caattcaagc aactctacgg gctattctaa ttcaggtttc tctagaatcg 28080 gggttggggt tattctctgt cttgtgattc tctttattct tatactaacg cttctctgcc 28140 taaggctcgc cgcctgctgt gtgcacattt gcatttattg tcagcttttt aaacgctggg 28200 gtcgccaccc aagatgatta ggtacataat cctaggttta ctcacccttg cgtcagccca 28260 cggtaccacc caaaaggtgg attttaagga gccagcctgt aatgttacat tcgcagctga 28320 agctaatgag tgcaccactc ttataaaatg caccacagaa catgaaaagc tgcttattcg 28380 ccacaaaaac aaaattggca agtatgctgt ttatgctatt tggcagccag gtgacactac 28440 agagtataat gttacagttt tccagggtaa aagtcataaa acttttatgt atacttttcc 28500 attttatgaa atgtgcgaca ttaccatgta catgagcaaa cagtataagt tgtggccccc 28560 acaaaattgt gtggaaaaca ctggcacttt ctgctgcact gctatgctaa ttacagtgct 28620 cgctttggtc tgtaccctac tctatattaa atacaaaagc agacgcagct ttattgagga 28680 aaagaaaatg ccttaattta ctaagttaca aagctaatgt caccactaac tgctttactc 28740 gctgcttgca aaacaaattc aaaaagttag cattataatt agaataggat ttaaaccccc 28800 cggtcatttc ctgctcaata ccattcccct gaacaattga ctctatgtgg gatatgctcc 28860 agcgctacaa ccttgaagtc aggcttcctg gatgtcagca tctgactttg gccagcacct 28920 gtcccgcgga tttgttccag tccaactaca gcgacccacc ctaacagaga tgaccaacac 28980 aaccaacgcg gccgccgcta ccggacttac atctaccaca aatacacccc aagtttctgc 29040 ctttgtcaat aactgggata acttgggcat gtggtggttc tccatagcgc ttatgtttgt 29100 atgccttatt attatgtggc tcatctgctg cctaaagcgc aaacgcgccc gaccacccat 29160 ctatagtccc atcattgtgc tacacccaaa caatgatgga atccatagat tggacggact 29220 gaaacacatg ttcttttctc ttacagtatg attaaatgag acatgattcc tcgagttttt 29280 atattactga cccttgttgc gcttttttgt gcgtgctcca cattggctgc ggtttctcac 29340 atcgaagtag actgcattcc agccttcaca gtctatttgc tttacggatt tgtcaccctc 29400 acgctcatct gcagcctcat cactgtggtc atcgccttta tccagtgcat tgactgggtc 29460 tgtgtgcgct ttgcatatct cagacaccat ccccagtaca gggacaggac tatagctgag 29520 cttcttagaa ttctttaatt atgaaattta ctgtgacttt tctgctgatt atttgcaccc 29580 tatctgcgtt ttgttccccg acctccaagc ctcaaagaca tatatcatgc agattcactc 29640 gtatatggaa tattccaagt tgctacaatg aaaaaagcga tctttccgaa gcctggttat 29700 atgcaatcat ctctgttatg gtgttctgca gtaccatctt agccctagct atatatccct 29760 accttgacat tggctggaac gcaatagatg ccatgaacca cccaactttc cccgcgcccg 29820 ctatgcttcc actgcaacaa gttgttgccg gcggctttgt cccagccaat cagcctcgcc 29880 caccttctcc cacccccact gaaatcagct actttaatct aacaggagga gatgactgac 29940 accctagatc tagaaatgga cggaattatt acagagcagc gcctgctaga aagacgcagg 30000 gcagcggccg agcaacagcg catgaatcaa gagctccaag acatggttaa cttgcaccag 30060 tgcaaaaggg gtatcttttg tctggtaaag caggccaaag tcacctacga cagtaatacc 30120 accggacacc gccttagcta caagttgcca accaagcgtc agaaattggt ggtcatggtg 30180 ggagaaaagc ccattaccat aactcagcac tcggtagaaa ccgaaggctg cattcactca 30240 ccttgtcaag gacctgagga tctctgcacc cttattaaga ccctgtgcgg tctcaaagat 30300 cttattccct ttaactaata aaaaaaaata ataaagctta atcacttact tgaaatcagc 30360 aataaggtct ctgttgaaat tttctcccag cagcacctca cttccctctt cccaactctg 30420 gtattctaaa ccccgttcag cggcatactt tctccatact ttaaagggga tgtcaaattt 30480 tagctcctct cctgtaccca caatcttcat gtctttcttc ccagatgacc aagagagtcc 30540 ggctcagtga ctccttcaac cctgtctacc cctatgaaga tgaaagcacc tcccaacacc 30600 cctttataaa cccagggttt atttccccaa atggcttcac acaaagccca aacggagttc 30660 ttactttaaa atgtttaacc ccactaacaa ccacaggcgg atctctacag ctaaaagtgg 30720 gagggggact tacagtggat gacaccaacg gttttttgaa agaaaacata agtgccacca 30780 caccactcgt taagactggt cactctatag gtttaccact aggagccgga ttgggaacga 30840 atgaaaataa actttgtatc aaattaggac aaggacttac attcaattca aacaacattt 30900 gcattgatga caatattaac accttatgga caggagtcaa ccccaccgaa gccaactgtc 30960 aaatcatgaa ctccagtgaa tctaatgatt gcaaattaat tctaacacta gttaaaactg 31020 gagcactagt cactgcattt gtttatgtta taggagtatc taacaatttt aatatgctaa 31080 ctacacacag aaatataaat tttactgcag agctgttttt cgattctact ggtaatttac 31140 taactagact ctcatccctc aaaactccac ttaatcataa atcaggacaa aacatggcta 31200 ctggtgccat tactaatgct aaaggtttca tgcccagcac gactgcctat cctttcaatg 31260 ataattctag agaaaaagaa aactacattt acggaacttg ttactacaca gctagtgatc 31320 gcactgcttt tcccattgac atatctgtca tgcttaaccg aagagcaata aatgacgaga 31380 catcatattg tattcgtata acttggtcct ggaacacagg agatgcccca gaggtgcaaa 31440 cctctgctac aaccctagtc acctccccat ttacctttta ctacatcaga gaagacgact 31500 aataaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca gaaaatttcg 31560 aatcattttt cattcagtag tatagcccca ccaccacata gcttatacag atcaccgtac 31620 cttaatcaaa ctcacagaac cctagtattc aacctgccac ctccctccca acacacagag 31680 tacacagtcc tttctccccg gctggcctta aaaagcatca tatcatgggt aacagacata 31740 ttcttaggtg ttatattcca cacggtttcc tgtcgagcca aacgctcatc agtgatatta 31800 ataaactccc cgggcagctc acttaagttc atgtcgctgt ccagctgctg agccacaggc 31860 tgctgtccaa cttgcggttg cttaacgggc ggcgaaggag aagtccacgc ctacatgggg 31920 gtagagtcat aatcgtgcat caggataggg cggtggtgct gcagcagcgc gcgaataaac 31980 tgctgccgcc gccgctccgt cctgcaggaa tacaacatgg cagtggtctc ctcagcgatg 32040 attcgcaccg cccgcagcat aaggcgcctt gtcctccggg cacagcagcg caccctgatc 32100 tcacttaaat cagcacagta actgcagcac agcaccacaa tattgttcaa aatcccacag 32160 tgcaaggcgc tgtatccaaa gctcatggcg gggaccacag aacccacgtg gccatcatac 32220 cacaagcgca ggtagattaa gtggcgaccc ctcataaaca cgctggacat aaacattacc 32280 tcttttggca tgttgtaatt caccacctcc cggtaccata taaacctctg attaaacatg 32340 gcgccatcca ccaccatcct aaaccagctg gccaaaacct gcccgccggc tatacactgc 32400 agggaaccgg gactggaaca atgacagtgg agagcccagg actcgtaacc atggatcatc 32460 atgctcgtca tgatatcaat gttggcacaa cacaggcaca cgtgcataca cttcctcagg 32520 attacaagct cctcccgcgt tagaaccata tcccagggaa caacccattc ctgaatcagc 32580 gtaaatccca cactgcaggg aagacctcgc acgtaactca cgttgtgcat tgtcaaagtg 32640 ttacattcgg gcagcagcgg atgatcctcc agtatggtag cgcgggtttc tgtctcaaaa 32700 ggaggtagac gatccctact gtacggagtg cgccgagaca accgagatcg tgttggtcgt 32760 agtgtcatgc caaatggaac gccggacgta gtcatatttc ctgaagcaaa accaggtgcg 32820 ggcgtgacaa acagatctgc gtctccggtc tcgccgctta gatcgctctg tgtagtagtt 32880 gtagtatatc cactctctca aagcatccag gcgccccctg gcttcgggtt ctatgtaaac 32940 tccttcatgc gccgctgccc tgataacatc caccaccgca gaataagcca cacccagcca 33000 acctacacat tcgttctgcg agtcacacac gggaggagcg ggaagagctg gaagaaccat 33060 gttttttttt ttattccaaa agattatcca aaacctcaaa atgaagatct attaagtgaa 33120 cgcgctcccc tccggtggcg tggtcaaact ctacagccaa agaacagata atggcatttg 33180 taagatgttg cacaatggct tccaaaaggc aaacggccct cacgtccaag tggacgtaaa 33240 ggctaaaccc ttcagggtga atctcctcta taaacattcc agcaccttca accatgccca 33300 aataattctc atctcgccac cttctcaata tatctctaag caaatcccga atattaagtc 33360 cggccattgt aaaaatctgc tccagagcgc cctccacctt cagcctcaag cagcgaatca 33420 tgattgcaaa aattcaggtt cctcacagac ctgtataaga ttcaaaagcg gaacattaac 33480 aaaaataccg cgatcccgta ggtcccttcg cagggccagc tgaacataat cgtgcaggtc 33540 tgcacggacc agcgcggcca cttccccgcc aggaaccatg acaaaagaac ccacactgat 33600 tatgacacgc atactcggag ctatgctaac cagcgtagcc ccgatgtaag cttgttgcat 33660 gggcggcgat ataaaatgca aggtgctgct caaaaaatca ggcaaagcct cgcgcaaaaa 33720 agaaagcaca tcgtagtcat gctcatgcag ataaaggcag gtaagctccg gaaccaccac 33780 agaaaaagac accatttttc tctcaaacat gtctgcgggt ttctgcataa acacaaaata 33840 aaataacaaa aaaacattta aacattagaa gcctgtctta caacaggaaa aacaaccctt 33900 ataagcataa gacggactac ggccatgccg gcgtgaccgt aaaaaaactg gtcaccgtga 33960 ttaaaaagca ccaccgacag ctcctcggtc atgtccggag tcataatgta agactcggta 34020 aacacatcag gttgattcac atcggtcagt gctaaaaagc gaccgaaata gcccggggga 34080 atacataccc gcaggcgtag agacaacatt acagccccca taggaggtat aacaaaatta 34140 ataggagaga aaaacacata aacacctgaa aaaccctcct gcctaggcaa aatagcaccc 34200 tcccgctcca gaacaacata cagcgcttcc acagcggcag ccataacagt cagccttacc 34260 agtaaaaaag aaaacctatt aaaaaaacac cactcgacac ggcaccagct caatcagtca 34320 cagtgtaaaa aagggccaag tgcagagcga gtatatatag gactaaaaaa tgacgtaacg 34380 gttaaagtcc acaaaaaaca cccagaaaac cgcacgcgaa cctacgccca gaaacgaaag 34440 ccaaaaaacc cacaacttcc tcaaatcgtc acttccgttt tcccacgtta cgtcacttcc 34500 cattttaaga aaactacaat tcccaacaca tacaagttac tccgccctaa aacctacgtc 34560 acccgccccg ttcccacgcc ccgcgccacg tcacaaactc caccccctca ttatcatatt 34620 ggcttcaatc caaaataagg tatattattg atgatgtagg gataacaggg taat 34674 <210> 75 <211> 33822 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO167) <400> 75 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgcctt aatgaacggg accggcgggg ccttcgaagg ggggcttttt agcccttatt 3660 tgacaacccg cctgccggga tgggccggag ttcgtcagaa tgtgatggga tcgacggtgg 3720 atgggcgccc agtgcttcca gcaaattcct cgaccatgac ctacgcgacc gtggggagct 3780 cgtcgctcga cagcaccgcc gcagccgcgg cagccgcagc tgccatgaca gcgacgagac 3840 tggcctcgag ctacatgccc agcagcggca gcagcccctc tgtgcccagt tccatcatcg 3900 ccgaggagaa actgctggcc ctgctggccg agctggaagc cctgagccgc cagctggccg 3960 ccctgaccca gcaggtgtcc gagctccgcg agcagcaaca gcagcaaaat aaataaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagca agtaaacaca gattctgatt 4080 caaacagcaa agcatcttta ttatttattt tttcgcgcgc ggtaggccct ggtccacctc 4140 tcccgatcat tgagagtgcg gtggattttt tccaggaccc ggtagaggtg ggattggatg 4200 ttgaggtaca tgggcatgag cccgtcccgg gggtggaggt agcaccactg catggcctcg 4260 tgctctgggg tcgtgttgta gatgatccag tcatagcagg ggcgctgggc gtggtgctgg 4320 atgatgtctt tgagaaggag actgatggcc acggggagcc ccttggtgta ggtattggcg 4380 aagcggttga gctgggaggg atgcatgcgg ggggagatga tgtgcagttt ggcctggatc 4440 ttgaggttgg cgatgttgcc acccagatcc cgccgggggt tcatgttgtg caggaccacc 4500 aggacggtgt agcccgtgca cttggggaac ttgtcatgca acttggaagg gaatgcgtgg 4560 aagaatttgg agacgccctt gtgcccgccc aggttttcca tgcattcatc catgatgatg 4620 gcgatgggcc cgtgggctgc ggctttggca aagacgtttc tggggtcaga tacatcataa 4680 ttatgctcct gggtgagatc atcataagac attttaatga atttggggcg gagggtgcca 4740 gattggggga cgatggttcc ctcgggcccc ggggcgaagt tcccctcaca gatctgcatc 4800 tcccaggctt tcatctcgga gggggggatc atgtccacct gcggggcgat gaaaaaaacg 4860 gtttccgggg ctggggtgat gagctgcgaa gagagcaggt ttctcaacag ctgggacttg 4920 ccgcacccgg tcgggccgta gatgaccccg atgacgggtt gcaggtggta gttcaaggac 4980 atgcagctgc cgtcgtcccg gaggaggggg gccacctcgt tgagcatgtc tctgacttgg 5040 aggttttccc gaacgagctc gccgaggagg cggtccccgc ccagcgagag gagctcttgc 5100 agggaagcaa agtttttcag gggcttgagt ccgtcggcca tgggcatctt ggcgagggtc 5160 tgcgagagga gctccaggcg gtcccagagc tcggtgacgt gctctacggc atctcgatcc 5220 agcagacttc ctcgtttcgg gggttgggac gactgcgact gtagggcacg agacgatggg 5280 cgtccagcgc ggccagcgtc atgtccttcc agggtctcag ggtccgagtg agggtggtct 5340 ccgtcacggt gaaggggtgg gcccctggct gggcgcttgc aagggtgcgc ttgagactca 5400 tcctgctggt gctgaaacgg gcacggtctt cgccctgcga gtcggcgaga tagcagttga 5460 ccatgagctc gtagttgagg gcctcggcgg cgtggccctt ggcgcggagc ttgcccttgg 5520 aagagcgccc gcaggcggga cagaggaggg attgcagggc gtagagcttg ggggcgagaa 5580 agacggactc gggagcgaaa gcgtccgctc cgcagtgggc gcagacggtc tcgcactcga 5640 cgagccaggt gagctctggc tgctcggggt caaaaaccag ttttcccccg ttctttttga 5700 tgcgcttctt acctcgcgtc tccatgagtc tgtgtccgcg ctcggtgaca aacaggctgt 5760 cggtgtcccc gtagacggac ttgattggcc tgtcctgcag gggcgtcccg cggtcctcct 5820 cgtagagaaa ctcggaccac tctgagacaa aggcgcgcgt ccacgccaag acaaaggagg 5880 ccacgtgcga ggggtagcgg tcgttgtcca ctagggggtc caccttttcc accgtgtgca 5940 gacacatgtc cccctcctcc gcatccaaga aggtgattgg cttgtaggtg taggccacgt 6000 gaccgggggt ccccgacggg ggggtataaa agggggcggg tctgtgctcg tcctcactct 6060 cttccgcgtc gctgtccacg agcgccagct gttggggtag gtattccctc tcgagagcgg 6120 gcatgacctc ggcactcagg ttgtcagttt ctagaaacga ggaggatttg atgttggctt 6180 gccctgccgc gatgcttttt aggagacttt catccatctg gtcagaaaag actatttttt 6240 tattgtcaag cttggtggcg aaggagccat agagggcgtt ggatagaagc ttggcgatgg 6300 atctcatggt ctgatttttg tcacggtcgg cgcgctcctt ggccgcgatg tttagctgga 6360 catactcgcg cgcgacgcac ttccattcgg ggaagacggt ggtgcgctcg tcgggcacga 6420 tcctgacgcg ccagccgcgg ttatgcaggg tgaccaggtc cacgctggtg gccacctcgc 6480 cgcgcagggg ctcgttggtc cagcagagtc tgccgccctt gcgcgagcag aacgggggca 6540 gcacatcaag cagatgctcg tcaggggggt ccgcatcgat ggtgaagatg cccggacaga 6600 gttccttgtc aaaataatcg atttttgagg atgcatcatc caaggccatc tgccactcgc 6660 gggcggccag cgctcgctcg taggggttga ggggcggacc ccagggcatg ggatgagtga 6720 gggcggaggc gtacatgccg cagatgtcgt agacatagat gggctccgag aggatgccga 6780 tgtaggtggg ataacagcgc cccccgcgga tgctggcgcg cacgtagtca tacaactcgt 6840 gcgagggggc caagaaggcg gggccgagat tggtgcgctg gggctgctcg gcgcggaaga 6900 cgatctggcg aaagatggcg tgcgagttgg aggagatggt gggccgttgg aagatgttaa 6960 agtgggcgtg gggcaagcgg accgagtcgc ggatgaagtg cgcgtaggag tcttgcagct 7020 tggcgacgag ctcggcggtg acgaggacgt ccatggcgca gtagtccagc gtttcgcgga 7080 tgatgtcata acccgcctct cctttcttct cccacagctc gcggttgagg gcgtactcct 7140 cgtcatcctt ccagtactcc cggagcggga atcctcgatc gtccgcacgg taagagccca 7200 gcatgtagaa atggttcacg gccttgtagg gacagcagcc cttctccacg gggagggcgt 7260 aagcttgagc ggccttgcgg agcgaggtgt gcgtcagggc gaaggtgtcc ctgaccatga 7320 ctttcaagaa ctggtacttg aaatccgagt cgtcgcagcc gccgtgctcc cagagctcga 7380 aatcggtgcg cttcttcgag agggggttag gcagagcgaa agtgacgtca ttgaagagaa 7440 tcttgcctgc tcgcggcatg aaattgcggg tgatgcggaa agggcccggg acggaggctc 7500 ggttgttgat cacctgggcg gcaaggacga tctcgtcgaa gccgttgatg ttgtgcccga 7560 cgatgtagag ttccatgaat cgcgggcggc ctttgatgtg cggcagcttt ttgagctcct 7620 cgtaggtgag gtcctcgggg cattgcaggc cgtgctgctc tagcgcccac tcctggagat 7680 gtgggttggc ttgcatgaag gaagcccaga gctcgcgggc catgagggtc tggagctcgt 7740 cgcgaaagag gcggaactgc tggcccacgg ccatcttttc tggggtgacg cagtagaagg 7800 tgagggggtc ccgctcccag cgatcccagc gtaagcgcac ggcgagatcg cgagcgaggg 7860 cgaccagctc gggttccccc gagaatttca tgaccagcat gaaggggacg agctgcttgc 7920 cgaaggaccc catccaggtg taggtttcta catcgtaggt gacaaagagc cgctccgtgc 7980 gaggatgaga gccgattggg aagaactgga tttcctgcca ccagttggac gagtggctgt 8040 tgatgtgatg aaagtagaaa tcccgccggc gaaccgagca ctcgtgctga tgcttgtaaa 8100 agcgtccgca gtactcgcag cgctgcacgg gctgtacctc atccacgaga tacacagcgc 8160 gtcccttgag gaggaacttc aggagtggcg gccctggctg gtggctttca tgttcgcctg 8220 cgtgggactc accctggggc tcctcgagga cggagaggct gacgagcccg cgcgggagcc 8280 aggtccagat ctcggcgcgg cgggggcgga gagcgaagac gagggcgcgc agttgggagc 8340 tgtccatggt gtcgcggaga tccaggtccg ggggcagggt tctgaggttg acctcgtaga 8400 ggcgggtgag ggcgtgcttg agatgcagat ggtacttgat ctccacgggt gagttggtgg 8460 tcgtgtccac gcattgcatg agcccgtagc tgcgcggggc cacgaccgtg ccgcggtgcg 8520 cttttagaag cggtgtcgcg ggcgtgctcc cggcggcagc ggcggttctg gccccgcggg 8580 caggggcggc agaggcacgt cggcgtggcg ctcgggcagg tcccggtgct gcgccctgag 8640 agcgctggcg tgcgcgacga cgcggcggtt gacatcctgg atctgccgcc tctgcgtgaa 8700 gaccacgggc cccgtgactt tgaacctgaa agacagttca acagaatcaa tctctgcgtc 8760 attgacggcg gcctgacgca ggatctcttg cacgtcgccc gagttgtcct ggtaggcgat 8820 ctcggtcatg aactgttcga tctcctcctc ctggagatcg ccgcggcccg cgcgctccac 8880 ggtggcggcg aggtcattgg agatgcggcc catgagctgc gagaaggcgc ccaggccgct 8940 ctcgttccag acgcggctgt agaccacgtc cccgtcggcg tcgcgtgcgc gcatgaccac 9000 ctgcgcgagg ttgagctcca cgtgccgcgt gaagacggcg tagttgcgca ggcgctggaa 9060 gaggtagttg agggtggtgg cgatgtgctc ggtgacgaag aagtacatga tccagcggcg 9120 caggggcatc tcgctgatgt cgccgatggc ctccagcctt tccatggcct cgtagaaatc 9180 cacggcgaag ttgaaaaact gggcattgcg ggccgagacc gtgagctcgt cttccaggag 9240 ccggatgagc tcggcgatgg tggcgcgcac ctcgcgctcg aaatccccgg gggcctcctc 9300 ttcttcctct tcttccatga cgacctcttc ttctatttct tcctctgggg gcggtggtgg 9360 tggcggggcc cgacgacgac ggcgacgcac cgggagacgg tcgacgaagc gctcgatcat 9420 ctccccgcgg cggcgacgca tggtttcggt gacggcgcga ccccgttcgc gaggacgcag 9480 cgtgaagacg ccgccggtca tctcccggta atggggcggg tccccgttgg gcagcgatag 9540 ggcgctgacg atgcatctta tcaattgcgg tgtaggggac gtgagcgcgt cgagatcgac 9600 cggatcggag aatctttcga ggaaagcgtc tagccaatcg cagtcgcaag gtaagctcaa 9660 acacgtagca gccctgtgga cgctgttaga attgcggttg ctgatgatgt aattgaagta 9720 ggcgtttttg aggcggcgga tggtggcgag gaggaccagg tccttgggtc ccgcttgctg 9780 gatgcggagc cgctcggcca tgccccaggc ctggccctga caccggctca ggttcttgta 9840 gtagtcatgc atgagcctct cgatgtcatc actggcggag gcggagtctt ccatgcgggt 9900 gaccccgacg cccctgagcg gctgcacgag cgccaggtcg gcgacgacgc gctcggcgag 9960 gatggcctgt tgcacgcggg tgagggtgtc ctggaagtcg tccatgtcga caaagcggtg 10020 gtaggccccg gtgttgatgg tgtaggtgca gttggccatg agcgaccagt tgacggtctg 10080 caggccgggt tgcacgacct cggagtacct gagccgcgag aaggcgcgcg agtcgaagac 10140 gtagtcattg caggtgcgca cgaggtactg gtagccgact aggaagtgcg gcggcggctg 10200 gcggtagagc ggccagcgct gggtggccgg cgcgcccggg gccaggtcct cgagcatgag 10260 gcggtggtag ccgtagaggt agcgggacat ccaggtgatg ccggcggcgg tggtggaggc 10320 gcgcgggaac tcgcggacgc ggttccagat gttgcgcagc ggcaggaaat agtccatggt 10380 cggcacggtc tggccggtga gacgcgcgca gtcattgacg ctctagaggc aaaaacgaaa 10440 gcggttgagc gggctcttcc tccgtagcct ggcggaacgc aaacgggtta ggccgcgtgt 10500 gtaccccggt tcgagtcccc ttgaatcagg ctggagccgc gactaacgtg gtattggcac 10560 tcccgtctcg acccgagccc gatagccgcc aggatacggc ggagagtcct ttttgccggc 10620 caaggggggt cgctagactt gaaagcgacc gaaaaccctg ccgggtagtg gctcgcgccc 10680 gtagtctgga gaagcatcgc cagggttgag tcgcggcaga acccggttcg cggacggccg 10740 cggcgagcgg gacttggtca ccccgccgat ttaaagaccc acagccagcc gacttctcca 10800 gttacgggag cgagccccct tttttctttt tgccagatgc atcccgtcct gcgccaaatg 10860 cgtcccaccc ccccggcgac caccgcgacc gcggccgtag caggcgccgg cgctagccag 10920 ccacagccac agacagagat ggacttggaa gagggcgaag ggctggcgag actgggggcg 10980 ccgtccccgg agcgacaccc ccgcgtgcag ctgcagaagg acgtgcgccc ggcgtacgtg 11040 cctgcgcaga acctgttcag ggaccgcagc ggggaggagc ccgaggagat gcgcgactgc 11100 cggtttcggg cgggcaggga gctgcgcgag ggcctggacc gccagcgcgt gctgcgcgac 11160 gaggatttcg agccgaacga gcagacgggg atcagccccg cgcgcgctca cgtggcggcg 11220 gccaacctgg tgacggccta cgagcagacg gtgaagcagg agcgcaactt ccaaaagagt 11280 ttcaacaacc acgtgcgcac cctgatcgcg cgcgaggagg tggccctggg cctgatgcac 11340 ctgtgggacc tggcggaggc catcgtgcag aacccggaca gcaagcctct gacggcgcag 11400 ctgttcctgg tggtgcagca cagcagggac aacgaggcgt tcagggaggc actgctgaac 11460 atcgccgagc ccgagggtcg ctggctgctg gagctgatca acatcttgca gagcatcgta 11520 gtgcaggagc gcagcctgag cttggccgag aaggtggcgg cgatcaacta ctcggtgctg 11580 agcctgggca agttttacgc gcgcaagatt tacaagacgc cgtacgtgcc catagacaag 11640 gaggtgaaga tagacagctt ttacatgcgc atggcgctca aggtgctgac gctgagcgac 11700 gacctgggcg tgtaccgcaa cgaccgcatc cacaaggccg tgagcacgag ccggcggcgc 11760 gagctaagcg accgcgagct gatgctgagc ctgcgccggg cgctggtagg gggcgctgcc 11820 ggcggcgagg agtcctactt cgacatgggg gcggacctgc attggcagcc gagccggcgc 11880 gccttggagg ccgcctacgg tccagaggac ttggatgagg aagaggaaga ggaggaggat 11940 gcacccgctg cggggtactg acgcctccgt gatgtgtttt tagatgcagc aagccccgga 12000 ccccgccata agggcggcgc tgcaaagcca gccgtccggt ctagcatcgg acgactggga 12060 ggccgcgatg caacgcatca tggccctgac gacccgcaac cccgagtcct ttagacaaca 12120 gccgcaggcc aacagactct cggccattct ggaggcggtg gtcccctctc ggaccaaccc 12180 cacgcacgag aaggtgctgg cgatcgtgaa cgcgctggcg gagaacaagg ccatccgtcc 12240 cgacgaggcc gggctggtgt acaacgccct gctggagcgc gtgggccgct acaacagcac 12300 gaacgtgcag tccaacctgg accggctggt gacggacgtg cgcgaggccg tggcgcagcg 12360 cgagcggttc aagaacgagg gcctgggctc gctggtggcg ctgaacgcct tcctggcgac 12420 gcagccggcg aacgtgccgc gcgggcagga cgattacacc aactttatca gcgcgctgcg 12480 gctgatggtg accgaggttc cccagagcga ggtgtaccag tcgggcccgg actacttttt 12540 ccagacgagc cggcagggct tgcagacggt gaacctgagc caggctttca agaacctgcg 12600 agggctgtgg ggcgtgcagg cgcccgtggg cgaccggtcg acggtgagca gcttgctgac 12660 gcccaactcg cggctgctgc tgctgctgat cgcgcccttc accgacagcg gcagcgtgaa 12720 ccgcaactcg tacctgggcc atctgctgac gctgtaccgc gaggccatag gccaggcgca 12780 ggtggacgag cagaccttcc aggagatcac tagcgtgagc cgcgcgctgg ggcagaacga 12840 caccgacagt ctgagggcca ccctgaactt cttgctgacc aatagacagc agaagatccc 12900 ggcgcaatat gcgctgtcgg ccgaggagga aaggatcctg agatatgtgc agcagagcgt 12960 agggctgttc ctgatgcagg agggggccac ccccagcgcc gcgctggaca tgaccgcgcg 13020 caacatggaa cctagcatgt acgccgccaa ccggccgttc atcaataagc tgatggacta 13080 cctgcaccgc gcggcggtca tgaacacgga ctactttaca aacgccatcc tgaacccgca 13140 ctggctcccg ccgccggggt tctacacggg cgagtacgac atgcccgacc ccaacgacgg 13200 gttcctgtgg gacgacgtgg acagcgtggt gttctcgccg acctttcaaa agcgccagga 13260 ggcgccgccg agcgagggcg cggtggggag gagccccttt cctagcttag ggagtttgca 13320 tagcttgccg ggctcggtga acagcggcag ggtgagccgg ccgcgcttgc tgggcgagga 13380 cgagtacctg aacgactcgc tgctgcagcc gccgcgggcc aagaacgcca tggccaataa 13440 cgggatagag agtctggtgg acaaactgaa ccgttggaag acctacgctc aggaccatag 13500 ggatgcgccc gcgccgcggc gacagcgcca cgaccggcag cggggcctgg tgtgggacga 13560 cgaggactcg gccgacgata gcagcgtgtt ggacttgggc gggagcggtg gggtcaaccc 13620 gttcgcgcat ctgcagccca aactggggcg acggatgttt tgaaatgcaa aataaaactc 13680 accaaggcca tagcgtgcgt tctcttcctt gttagagatg aggcgtgcgg tggtgtcttc 13740 ctctcctcct ccctcgtacg agagcgtgat ggcgcaggcg accctggagg ttccgtttgt 13800 gcctccgcgg tatatggctc ctacggaggg cagaaacagc attcgttact cggagctggc 13860 tccgcagtac gacaccactc gcgtgtactt ggtggacaac aagtcggcgg acatcgcttc 13920 cctgaactac caaaacgacc acagcaactt cctgaccacg gtggtgcaga acaacgattt 13980 cacccccgcc gaggccagca cgcagacgat aaattttgac gagcggtcgc ggtggggcgg 14040 tgatctgaag accattctgc acactaacat gcccaatgtg aacgagtaca tgttcaccag 14100 caagtttaag gcgcgggtga tggtggctag gaagcatcca gagggggtag ttgaaacaga 14160 tttgagtcag gataagcttg aatatgagtg gtttgagttt accctgcccg agggaaactt 14220 ttccgagacc atgaccatag acctgatgaa caacgccatc ttggaaaact acttgcaagt 14280 ggggcggcaa aatggcgtgc tggagagcga tatcggagtc aagtttgaca gcagaaattt 14340 caagctgggc tgggacccgg tgaccaagct ggtgatgcca ggggtctaca cctacgaggc 14400 cttccacccg gacgtggtgc tgctgccggg ctgcggggtg gacttcaccg agagccgcct 14460 gagcaacctc ctgggcattc gcaagaagca acctttccaa gagggcttca gaatcatgta 14520 tgaggatcta gaaggtggca acatccccgc cctccttgat gtgcccaagt acttggaaag 14580 caagaagaaa gttgaagacg aaactaaaaa tgcagctgcg gctacagccg atacaaccac 14640 taggggtgat acatttgcaa ctccagcgca agagacagca gctgataaga aggtagaagt 14700 cttgcccatt gaaaaggatg agagtggtag aagttacaac ctgatccagg ggacccacga 14760 cacgctgtac cgcagttggt acctgtccta tacctacggg gaccccgaga agggggtgca 14820 gtcgtggacg ctgctcacca ccccggacgt cacctgcggc gcggagcaag tctactggtc 14880 gctgccggac ctcatgcaag acccagtcac cttccgctct acccagcaag tcagcaacta 14940 ccccgtggtc ggcgccgagc tcatgccctt ccgcgccaag agcttttaca acgacctcgc 15000 cgtctactcc cagctcatcc gcagctacac ctccctcacc cacgtcttca accgcttccc 15060 cgacaaccag atcctctgcc gcccgcccgc gcccaccatc accaccgtca gtgaaaacgt 15120 gcctgctctc acagatcacg ggacgctacc gctgcgcagc agtatccgcg gagtccagcg 15180 agtgaccgtc actgacgccc gtcgccgcac ctgtccctac gtctacaagg ccctgggcat 15240 agtcgcgccg cgcgtgcttt ccagtcgcac cttctaaaaa aatgtctatt ctcatctcgc 15300 ccagcaataa caccggctgg ggtcttacta gacccagcac catgtacgga ggagccaaga 15360 agcgctccca gcagcacccc gtccgcgtcc gcggccactt ccgcgctccc tggggcgctt 15420 acaagcgcgg gcggacttcc accgccgtgc gcaccaccgt cgacgacgtc atcgactcgg 15480 tggtcgccga cgcgcgcaac tatacccccg ccccctccac cgtggacgcg gtcatcgaca 15540 gcgtggtggc cgacgcgcgc gactatgcca gacgcaagag ccggcggcga cggatcgcca 15600 ggcgccaccg gagcacgccc gccatgcgcg ccgcccgggc tctgctgcgc cgcgccagac 15660 gcacgggccg ccgggccatg atgcgagccg cgcgccgcgc tgccactgca cccacccccg 15720 caggcaggac tcgcagacga gcggccgccg ccgccgccgc ggccatctct agcatgacca 15780 gacccaggcg cggaaacgtg tactgggtgc gcgactccgt cacgggcgtg cgcgtgcccg 15840 tgcgcacccg tcctcctcgt ccctgatcta atgcttgtgt cctcccccgc aagcgacgat 15900 gtcaaagcgc aaaatcaagg aggagatgct ccaggtcgtc gccccggaga tttacggacc 15960 accccaggcg gaccagaaac cccgcaaaat caagcgggtt aaaaaaaagg atgaggtgga 16020 cgagggggca gtagagtttg tgcgcgagtt cgctccgcgg cggcgcgtaa attggaaggg 16080 gcgcagggtg cagcgcgtgt tgcggcccgg cacggcggtg gtgttcacgc ccggcgagcg 16140 gtcctcagtc aggagcaagc gtagctatga cgaggtgtac ggcgacgacg acatcctgga 16200 ccaggcggcg gagcgggcgg gcgagttcgc ctacgggaag cggtcgcgcg aagaggagct 16260 gatctcgctg ccgctggacg aaagcaaccc cacgccgagc ctgaagcccg tgaccctgca 16320 gcaggtgctg ccccaggcgg tgctgctgcc gagccgcggg gtcaagcgcg agggcgagag 16380 catgtacccg accatgcaga tcatggtgcc caagcgccgg cgcgtggagg acgtgctgga 16440 caccgtgaaa atggatgtgg agcccgaggt caaggtgcgc cccatcaagc aggtggcgcc 16500 gggcctgggc gtgcagaccg tggacattca gatccccacc gacatggatg tcgacaaaaa 16560 accctcgacc agcatcgagg tgcagaccga cccctggctc ccagcctcca ctgctaccgt 16620 ctccacttct accgccgcca cggctaccga gcctcccagg aggcgaagat ggggcgccgc 16680 cagccggctg atgcccaact acgtggtgca tccttccatc atcccgacgc cgggctaccg 16740 cggcacccgg tactacgcca gccgccggcg cccagccagc aaacgccgcc gccgcaccgc 16800 cacccgccgc cgtctggccc ccgcccgcgt gcgccgcgtg accacgcgcc ggggccgctc 16860 gctcgttctg cccaccgtgc gctaccaccc cagcatcctt taattcgtgt gctgtgatac 16920 tgttgcagag agatggctct cacttgccgc ctgcgcatcc ccgtcccgaa ttaccgagga 16980 agatcccgcc gcaggagagg catggcaggc agcggcctga accgccgccg gcggcgggcc 17040 atgcgcaggc gcctgagtgg cggctttctg cccgcgctca tccccataat cgccgcggcc 17100 atcggcacga tcccgggcat agcttccgtt gcgctgcagg cgtcgcagcg ccgttgatgt 17160 gcgaataaaa gcctctttag actctgacac acctggtcct gtatattttt agaatggaag 17220 acatcaattt tgcgtccctg gctccgcggc acggcacgcg gccgttcatg ggcacctgga 17280 acgagatcgg caccagccag ctgaacgggg gcgccttcaa ttggagcagt gtctggagcg 17340 ggcttaaaaa tttcggctcg acgctccgga cctatgggaa caaggcctgg aatagtagca 17400 cggggcagtt gctaagggaa aagctcaaag accagaactt tcagcagaag gtggtggacg 17460 ggctggcctc gggcattaac ggggtggtgg acatcgcgaa ccaggccgtg cagcgcgaga 17520 taaacagccg cctggacccg cggccgccca cggtggtgga gatggaagat gcaactcttc 17580 cgccgcccaa aggcgagaag cggccgcggc ccgacgcgga ggagacgatc ctgcaggtgg 17640 acgagccgcc ctcgtacgag gaggccgtca aggccggcat gcccaccacg cgcatcatcg 17700 cgccgctggc cacgggtgta atgaaacccg ccacccttga cctgcctcca ccacccgcgc 17760 ccgctccacc gaaggcagct cccgcggtcg tgcaggcccc cccggtggcg accgccgtgc 17820 gccgcgtccc cgcccgccgc caggcccaga actggcagag cacgttgcac agtatcgtag 17880 gcctgggagt gaaaagtctg aagcgccgcc gatgctattg aaagagagga aagaggacac 17940 taaagggaga gcttaacttg tatgtgcctt accgccagag aacgcgcgaa gatggccacc 18000 ccctcgatga tgccgcagtg ggcgtacatg cacatcgccg ggcaggacgc ctcggagtac 18060 ctgagcccgg gtctggtgca gtttgcccgc gccaccgaca cgtacttcag cctgggcaac 18120 aagtttagga accccacggt ggccccgacc cacgatgtga ccacggaccg gtcccagcgt 18180 ctgacgctgc gcttcgtgcc cgtggatcgc gaggacacca cgtactcgta caaggcgcgc 18240 ttcactctgg ccgtgggcga caaccgggtg ctagacatgg ccagcactta ctttgacatc 18300 cgcggcgtcc tggaccgcgg tcccagcttc aaaccctact cgggcacagc ttacaacagt 18360 ctggccccca agggtgcccc caactccagc cagtggcttg caaaagacac caatgctggc 18420 gatcaagcat taaaaaccca cacacatggc gtagctgcta tggggggaac agatatcaca 18480 gcaaagggtt tgcaaattgg tgttgacacg actgaaaaca agaatgagcc tatttatgca 18540 aatgaaatat accagccaga acctcaggta ggagaggaaa acttgcaaga tgttgaaaac 18600 ttttatggag gcagagctct taaaaaagaa accaaaatga aaccttgcta tggctcgttt 18660 gccagaccca caaatgaaaa aggcggtcaa gccaaatttt taactgacgg cgatggtcag 18720 ctaactaaaa atcatgatat cacaatgaat ttctttgaca ctcctggagg aacagttggt 18780 caggatactg aacttgaagc agacattgtt atgtatgctg agaatgtgca tctggaaact 18840 ccagacacgc atgtggtgta caaaccagga acttctgatg agagttcaga agcaaatttg 18900 gttcagcagt ccatgccaaa caggcccaac tacatcggct tcagggacaa ctttgtgggt 18960 ctcatgtact ataacagcac tggcaacatg ggtgtgctgg ctggtcaagc atctcagttg 19020 aatgctgtgg tcgacttgca agacagaaac acagagctgt cttaccagct cttgctagat 19080 tctctgggtg acagaaccag atactttagc atgtggaact ctgcagtgga cagttatgat 19140 cctgatgtca ggattattga aaatcacggt gtggaagatg aacttccaaa ctattgcttc 19200 ccattggatg gagctggcac taatgctacc taccaaggtg taaaagttaa aaatggccaa 19260 gatggagatg taaacgcaga ttgggaaaaa gatccaaatc ttgcttcacg aaaccaaata 19320 tgcaagggta acatcttcgc catggagatc aacctccagg ccaacctgtg gaagagtttt 19380 ctgtactcga atgtggccct gtacctgccc gactcataca agtacacgcc ggccaacgtc 19440 acgctgcccg ccaataccaa cacctacgag tacatgaacg gccgcgtggt agccccctcg 19500 ctggtggacg cctacatcaa catcggcgcc cggtggtcgc tggaccccat ggacaacgtc 19560 aacccattca accaccaccg caacgcgggc ctgcgttacc gctccatgct tctgggcaac 19620 ggccgctacg tgcccttcca catccaagtg ccccaaaagt tctttgccat caagaacctg 19680 ctcctgctcc ccggctccta cacctacgag tggaacttcc gcaaggatgt caacatgatc 19740 ctgcagagtt ccctcggaaa cgacctgcgc gtcgacggcg cctccgtccg cttcgacagc 19800 gtcaacctct acgccacatt cttccccatg gcgcacaaca ccgcctccac cctggaagcc 19860 atgctgcgca acgacaccaa cgaccagtcc ttcaacgact acctctcggc cgccaacatg 19920 ctctacccca tcccggccaa ggccaccaac gtgcccatct ccatcccctc gcgcaactgg 19980 gccgccttcc gcggctggag tttcacccgg ctcaagacca aagaaactcc ctccctcggc 20040 tcgggtttcg atccctactt tgtatactcg ggttccatcc cctacctcga cgggaccttc 20100 tacctcaacc acaccttcaa gaaggtctcc atcatgttcg actcctcggt cagctggccc 20160 ggcaacgacc ggctgctcac gccgaacgag ttcgagatca agcgcagtgt cgacggggag 20220 ggctacaatg tggcccaatg caacatgacc aaggactggt tcctcgtcca gatgctctcc 20280 cactacaaca tcggctacca gggcttccac gtgcccgagg gctacaagga ccgcatgtac 20340 tccttcttcc gcaacttcca gcccatgagc aggcaggtgg tcgatgagat caactacaag 20400 gactacaagg ccgtcaccct gcccttccag cacaacaact cgggcttcac cggctacctt 20460 gcacccacca tgcgtcaggg gcagccctac cccgccaact tcccctatcc tctcatcggc 20520 cagacagccg tgccctctgt cacccagaaa aagttcctct gcgacagggt catgtggcgc 20580 atccccttct ccagcaactt catgtccatg ggcgccctca ccgacctggg tcagaacatg 20640 ctctatgcca actcggccca cgcgctcgac atgaccttcg aggtggaccc catggatgag 20700 cccaccctcc tctatcttct cttcgaagtt ttcgacgtgg tcagagtgca ccagccgcac 20760 cgcggcgtca tcgaggccgt ctacctgcgc acgcccttct ccgccggcaa cgccaccacc 20820 taagcatgag cggctccagc gaacgagagc tcgcggccat cgtgcgcgac ctgggctgcg 20880 ggccctactt tttgggcacc cacgacaagc gcttcccggg cttcctcgcc ggcgacaagc 20940 tggcctgcgc cattgtcaac acggccggcc gcgagaccgg aggcgtgcac tggctcgcct 21000 tcggctggaa cccgcgctcg cgcacctgct acatgttcga cccatttggg ttctcggacc 21060 gccggctcaa gcagatttac agcttcgagt acgaggctat gttgcgccga agcgccctgg 21120 cttcctcgcc cgaccgctgt ctcagcctcg agcagtccac ccagaccgtg caggggcccg 21180 actccgccgc ctgcggactt ttctgttgca tgttcttgca tgccttcgtg cactggcccg 21240 accgacccat ggacgggaac cccaccatga acttgctgac gggggtgccc aacggcatgc 21300 tacaatcgcc acaggtgctg cccaccctcc ggcgcaacca ggaggagctc taccgcttcc 21360 tcgcgcgcca ctccccttac tttcgctccc accgcgccgc catcgaacac gccaccgctt 21420 ttgacaaaat gaaacaactg cgtgtatctc aataaacagc acttttattt tacatgtact 21480 ggagtatatg caagttattt aaaagtcgaa ggggttctcg cgctcgtcgt tgtgcgccgc 21540 gctggggagg gccacgttgc ggtactggaa cttgggctgc cacttgaact cggggatcac 21600 cagtttgggc actggggtct cggggaaggt ctcgctccac atgcgccggc tcatctgcag 21660 ggcgcccagt atgtccgggg cggagatctt gaaatcgcag ttggggccgg tgctctgcgc 21720 gcgcgagttg cggtacacgg ggttgcagca ctggaacacc atcagactgg ggtacttcac 21780 actggccagc acgctcttgt cgctgatctg atccttgtcc aggtcctcgg cgttgctcag 21840 gccgaacggg gtcatcttgc acagctggcg gcccaggaag ggcacgctct gaggcttgtg 21900 gttacactcg cagtgcacgg gcatcagcat catccccgcg ccgcgctgca tattcgggta 21960 gagggccttg acaaaggccg agatctgctt gaaagcttgc tgggccttgg ccccctcgct 22020 gaaaaacagg ccgcagctct tcccgctgaa ctggttattc ccgcacccgg catcatgcac 22080 gcagcagcgc gcgtcatggc tggtcagttg caccacgctc cgtccccagc ggttctgggt 22140 caccttggcc ttgctaggct gctccttcaa cgcgcgctgg ccgttctcgc tggtcacatc 22200 catctccacc acgtggtcct tgtggatcat caccgtcccg tgcaaacact tgagctggcc 22260 ttccacctcg gtgcagccgt gatcccacag ggcgcagccg gtgcactccc aattcttgtg 22320 tgcgatcccg ctgtggctga agatgtaacc ttgcaacagg cgacccatga cggtgctaaa 22380 tgatttactg gtgctgaagg tcagttgcag accgcgggcc tcctcgttca tccaggtctg 22440 gcacatcttt tggaagatct cggtctgctc gggcatgagc ttgtaagcat cgcgcaggcc 22500 gctgtcgacg cggtagcgtt ccataagcac gttcatggta tccatgccct tctcccagga 22560 cgagaccaga ggcagactca gggggttgcg cacgttcaga ataccggggg tcgcgggctc 22620 gacgatgcgt tttccgtcct tgccttcctt caacagaacc ggcggctggc tgaatcccac 22680 tcccacgatc acggcatctt cctggggcat ctcttcgtcg gggtctacct tggtcacatg 22740 cttggtcttt ctggcttgct tcttttttgg agggctgtcc acggggacca cgtcctcctc 22800 ggaagacccg gagcccaccc gctgatactt tcggcgcttg gtgggcagag gaggtggagg 22860 cgaggggctc ctctcctgct ccggcggata gcgcgccgac ccgtggcccc ggggcggagt 22920 ggcctctcgc tccatgaacc ggcgcacgtc ctgactgccg ccggccattg tttcctaggg 22980 gaagatggag gagcagccgc gtaagcagga gcaggaggag gacttaacca cccacgagca 23040 acccaaaatc gagcaggacc tgggcttcga agagccggct cgtctagaac ccccacagga 23100 tgaacaggag cacgagcaag acgcaggcca ggaggagacc gacgctgggc tcgagcatgg 23160 ctacctggga ggagaggagg atgtgctgct gaaacacttg cagcgccagt ccctcatcct 23220 ccgggacgcc ctggccgacc ggagcgaaac ccccctcagc gtcgaggagc tgtgtcgggc 23280 ctacgagctc aacctcttct cgccgcgcgt gccccccaaa cgccagccca acggcacctg 23340 cgagcccaac ccgcgtctca acttctatcc cgttttcgcg gtccccgagg cccttgccac 23400 ctatcacatt tttttcaaga accaaaagat ccccgtctcc tgccgcgcca accgcacccg 23460 cgccgacgcg ctcctcgctc tggggcccgg cgcgcgcata cctgatatcg cttccctgga 23520 agaggtgccc aagatcttcg aagggctcgg tcgggacgag acgcgcgcgg cgaacgctct 23580 gaaagaaaca gcagaggaag agggtcacac tagcgccctg gtagagttgg aaggcgacaa 23640 cgccaggctg gccgtgctca agcgcagcgt cgagctcacc cactttgcct accccgccgt 23700 caacctcccg cccaaggtca tgcgtcacat catggatcag ctcatcatgc cccacatcga 23760 agccctcgat gaaagtcagg agcagcgccc cgaggacgcc cgacccgtgg tcagcgacga 23820 gatgctcgcg cgctggctcg ggacccgcga gccccaggct ttggaacagc ggcgcaagct 23880 catgctggcc gtggtcctgg tcaccctcga gctcgaatgc atgcgccgct tcttcagcga 23940 ccccgagacc ctgcgcaaag tcgaggagac cctgcactac actttcagac acggtttcgt 24000 caggcaggcc tgcaagattt ccaacgtgga gctgaccaac ctggtctcct gcctggggat 24060 cctgcatgag aaccgcctgg gacagaccgt actccactct accctgaagg gcgaggcgcg 24120 gagggactat gtccgcgact gcgtctttct ctttctctgc cacacatggc aagcagccat 24180 gggcgtgtgg cagcagtgtc tcgaggacga gaacctgaag gagctggaca agcttcttgc 24240 tagaaacctt aaaaagcttt ggacgggctt cgacgagcgc accgtcgcct cggacctggc 24300 cgagatcgtc ttccccgagc gcctgaggca gacgctgaaa ggcgggctgc ccgacttcat 24360 gagccagagc atgttgcaaa actaccgcac tttcattctc gagcgatcgg ggatgctgcc 24420 cgccacctgc aacgctttcc cctccgactt tgtcccgctg agctaccgcg agtgtccccc 24480 gccgctgtgg agccactgct acctcttgca gctggccaac tacatcgcct accactcgga 24540 cgtgatcgag gacgtgagcg gcgaggggct gctcgagtgc cactgccgct gcaacctgtg 24600 ctccccgcac cgctccctgg tctgcaaccc ccagctcctt agcgagaccc aggtcatcgg 24660 taccttcgag ctgcaaggtc cgcaggagtc caccgctccg ctgaaactca cgccggggtt 24720 gtggacttcc gcgtacctgc gcaaatttgt acccgaggac taccacgccc atgagataaa 24780 gttcttcgag gaccaatcgc ggccgcagca cgcggatctc acggcctgcg tcatcaccca 24840 gggcgcgatc ctcgcccaat tgcacgccat ccaaaaatcc cgccaagagt ttcttctgaa 24900 aaagggtaga ggggtctacc tggaccccca gacgggcgag gtgctcaaca cgggtctccc 24960 ccagcatgcc gaggaagaag caggagccgc tagtggagga gatggaagaa gaatgggaca 25020 gccaggcaga ggaggacgaa tgggaggagg agacagagga ggaagaattg gaagaggtgg 25080 aagaggagca ggcaacagag cagcccgtcg ccgcaccatc cgcgccggca gccccggcgg 25140 tcacggatac aacctccgca gctccggcca agcctcctcg tagatgggat cgagtgaagg 25200 gcgacggtaa gcacgagcgg cagggctacc gatcatggag ggcccacaaa gccgcgatca 25260 tcgcctgctt gcaagactgc ggggggaaca tcgctttcgc ccgccgctac ctgctcttcc 25320 accgcggggt gaacatcccc cgcaacgtgt tgcattacta ccgtcacctt cacagctaag 25380 aaaaagcaag taagagaagt cgccggagga ggcctgagga tcgcggcgaa cgagcccttg 25440 accaccaggg agctgaggaa ccggatcttc cccactcttt atgccatttt tcagcagagt 25500 cgaggtcagc agcaagagct caaagtaaaa aaccggtctc tgcgctcgct cacccgcagt 25560 tgcttgtacc acaaaaacga agatcagctg cagcgcactc tcgaagacgc cgaggctctg 25620 ttccacaagt actgcgcgct cactcttaaa gactaaggcg cgcccacccg gaaaaaaggc 25680 gggaattacc tcatcgccac catgagcaag gagattccca ccccttacat gtggagctat 25740 cagccccaga tgggcctggc cgcgggcgcc tcccaagact actccacacg catgaactgg 25800 ctcagtgccg gcccctcgat gatatcacgg gtcaacgggg tccgcagtca tcgaaaccag 25860 atattgttgg agcaggcggc ggtcacctcc acgcccaggg caaagctcaa cccgcgtaat 25920 tggccctcca ccctggtgta tcaggaaatc cccgggccga ctaccgtact acttccgcgt 25980 gacgcactgg ccgaagtccg catgactaac tcaggtgtcc agctggccgg cggcgcttcc 26040 cggtgcccgc tccgcccaca atcgggtata aaaaccctgg tgatccgagg cagaggcaca 26100 cagctcaacg acgagttggt gagctcttcg atcggtctgc gaccggacgg agtgttccaa 26160 ctagccggag ccgggagatc gtccttcact cccaaccagg cctacctgac cttgcagagc 26220 agctcttcgg agcctcgctc gggaggcatc ggaaccctcc agttcgtgga ggagtttgtg 26280 ccctcggtct acttcaaccc cttctcggga tcgccaggcc tctacccgga cgagttcata 26340 ccgaacttcg acgcagtgag agaagcggtg gacggctacg actgattaat gttaagtgga 26400 gaggcagagc aactgcgcct gaaacacctg gtccactgtc gccgccacaa gtgctttgcc 26460 cgcgactccg gtgagttttg ctactttgaa ttgcccgagg atcatatcga gggcccggcg 26520 cacggcgtcc ggcttaccgc ccagggagag cttgcccgta gcctgattcg ggagtttacc 26580 cagcgccccc tgctagttga gcgggacagg ggaccctgtg ttctcactgt gatttgcaac 26640 tgtcctaacc ctggattaca tcaagatctt tgttgccatc tctgtgctga gtataataaa 26700 tacagaaatt aaaatatact ggggctccta tcgccatcct gtaaacgcca ccgtcttcac 26760 ccgcccaagc aaaccaaggc gaaccttacc tggtactttt aacatctctc cctctgtgat 26820 ttacaacagt ttcaacccag acggagtgag tctacgagag aacctctccg agctcagcta 26880 ctccatcaga aaaaacacca ccctccttac ctgccgggaa cgtacgagtg cgtcaccggc 26940 cgctgcacca cacctaccgc ctgaccgtaa accagacttt ttccggacag acctcaataa 27000 ctctgtttac cagaacagga ggtgagctta gaaaaccctt agggtattag gccaaaggcg 27060 cagctactgt ggggtttatg aacaattcaa gcaactctac gggctattct aattcaggtt 27120 tctctagaat cggggttggg gttattctct gtcttgtgat tctctttatt cttatactaa 27180 cgcttctctg cctaaggctc gccgcctgct gtgtgcacat ttgcatttat tgtcagcttt 27240 ttaaacgctg gggtcgccac ccaagatgat taggtacata atcctaggtt tactcaccct 27300 tgcgtcagcc cacggtacca cccaaaaggt ggattttaag gagccagcct gtaatgttac 27360 attcgcagct gaagctaatg agtgcaccac tcttataaaa tgcaccacag aacatgaaaa 27420 gctgcttatt cgccacaaaa acaaaattgg caagtatgct gtttatgcta tttggcagcc 27480 aggtgacact acagagtata atgttacagt tttccagggt aaaagtcata aaacttttat 27540 gtatactttt ccattttatg aaatgtgcga cattaccatg tacatgagca aacagtataa 27600 gttgtggccc ccacaaaatt gtgtggaaaa cactggcact ttctgctgca ctgctatgct 27660 aattacagtg ctcgctttgg tctgtaccct actctatatt aaatacaaaa gcagacgcag 27720 ctttattgag gaaaagaaaa tgccttaatt tactaagtta caaagctaat gtcaccacta 27780 actgctttac tcgctgcttg caaaacaaat tcaaaaagtt agcattataa ttagaatagg 27840 atttaaaccc cccggtcatt tcctgctcaa taccattccc ctgaacaatt gactctatgt 27900 gggatatgct ccagcgctac aaccttgaag tcaggcttcc tggatgtcag catctgactt 27960 tggccagcac ctgtcccgcg gatttgttcc agtccaacta cagcgaccca ccctaacaga 28020 gatgaccaac acaaccaacg cggccgccgc taccggactt acatctacca caaatacacc 28080 ccaagtttct gcctttgtca ataactggga taacttgggc atgtggtggt tctccatagc 28140 gcttatgttt gtatgcctta ttattatgtg gctcatctgc tgcctaaagc gcaaacgcgc 28200 ccgaccaccc atctatagtc ccatcattgt gctacaccca aacaatgatg gaatccatag 28260 attggacgga ctgaaacaca tgttcttttc tcttacagta tgattaaatg agacatgatt 28320 cctcgagttt ttatattact gacccttgtt gcgctttttt gtgcgtgctc cacattggct 28380 gcggtttctc acatcgaagt agactgcatt ccagccttca cagtctattt gctttacgga 28440 tttgtcaccc tcacgctcat ctgcagcctc atcactgtgg tcatcgcctt tatccagtgc 28500 attgactggg tctgtgtgcg ctttgcatat ctcagacacc atccccagta cagggacagg 28560 actatagctg agcttcttag aattctttaa ttatgaaatt tactgtgact tttctgctga 28620 ttatttgcac cctatctgcg ttttgttccc cgacctccaa gcctcaaaga catatatcat 28680 gcagattcac tcgtatatgg aatattccaa gttgctacaa tgaaaaaagc gatctttccg 28740 aagcctggtt atatgcaatc atctctgtta tggtgttctg cagtaccatc ttagccctag 28800 ctatatatcc ctaccttgac attggctgga acgcaataga tgccatgaac cacccaactt 28860 tccccgcgcc cgctatgctt ccactgcaac aagttgttgc cggcggcttt gtcccagcca 28920 atcagcctcg cccaccttct cccaccccca ctgaaatcag ctactttaat ctaacaggag 28980 gagatgactg acaccctaga tctagaaatg gacggaatta ttacagagca gcgcctgcta 29040 gaaagacgca gggcagcggc cgagcaacag cgcatgaatc aagagctcca agacatggtt 29100 aacttgcacc agtgcaaaag gggtatcttt tgtctggtaa agcaggccaa agtcacctac 29160 gacagtaata ccaccggaca ccgccttagc tacaagttgc caaccaagcg tcagaaattg 29220 gtggtcatgg tgggagaaaa gcccattacc ataactcagc actcggtaga aaccgaaggc 29280 tgcattcact caccttgtca aggacctgag gatctctgca cccttattaa gaccctgtgc 29340 ggtctcaaag atcttattcc ctttaactaa taaaaaaaaa taataaagct tatcacttac 29400 ttgaaatctg aaagtatgtc tctggtgtag ttgttcagca gcacctcgtt accctcctcc 29460 cagctctggt attccagtcc ccggcgggcg gcgaacttcc tccacacctt gaaagggatg 29520 tcaaattcct ggtccacaat tttcattgtc ttccctctca gatgtcaaag aggctccggg 29580 tggaagatga cttcaacccc gtctacccct atggctacgc gcggaatcag aatatcccct 29640 tcctcactcc cccctttgtc tcctccgatg gattccaaaa cttcccccct ggggtcctgt 29700 cactcaaact ggctgaccca atagccatcg tcaatgggaa tgtctcactc aaagtgggag 29760 ggggtctcac tttgcaagat ggaactggaa aactaacagt caatgctgat ccacctttgc 29820 aacttacaaa caacaaatta gggattgctt tggacgctcc atttgatgtt atagacaata 29880 aactcacatt gttagcgggc catggcttgt ctattataac aaaagaaaca tcaacactgc 29940 ctggcttgat taatactctt gtagtattaa ctggaaaggg tattggaaca gaatcaacag 30000 ataatggcgg aagcgtatgt gttagagttg gagaaggtgg cggcttatca tttaataatg 30060 atggagactt ggtagcattt aataaaaaag aagataagcg caccctatgg acaactccag 30120 acacatctcc aaattgcaag attgatcaag ataaggactc taagttaact ctggtcctta 30180 caaagtgtgg aagtcaaata ttggctaatg tgtcattaat tgtcgtagct ggtaagtaca 30240 aaattatcaa taacaatact caaccagctc tcaaaggatt taccattaaa ttattgtttg 30300 atgaaaatgg agtacttatg gaatcttcaa atcttggtaa atcatattgg aactttagaa 30360 atgaaaattc aattatgtca acagcttatg aaaaagctat tggattcatg cctaatttgg 30420 tagcctatcc aaaacctacc gctggctcta aaaaatatgc aagagatata gtttatggaa 30480 acatctacct tggtggaaag ccagatcaac cagtaaccat taaaactacc tttaatcagg 30540 aaactggatg tgaatattct atcacatttg attttagttg ggccaagact tatgtaaatg 30600 ttgaatttga aacaacctct tttacctttt cctatatcgc ccaagaataa taaagaatcg 30660 tttgtgttat gtttcaacgt gtttattttt caattgcaga aaatttcgaa tcatttttca 30720 ttcagtagta tagccccacc accacatagc ttatacagat caccgtacct taatcaaact 30780 cacagaaccc tagtattcaa cctgccacct ccctcccaac acacagagta cacagtcctt 30840 tctccccggc tggccttaaa aagcatcata tcatgggtaa cagacatatt cttaggtgtt 30900 atattccaca cggtttcctg tcgagccaaa cgctcatcag tgatattaat aaactccccg 30960 ggcagctcac ttaagttcat gtcgctgtcc agctgctgag ccacaggctg ctgtccaact 31020 tgcggttgct taacgggcgg cgaaggagaa gtccacgcct acatgggggt agagtcataa 31080 tcgtgcatca ggatagggcg gtggtgctgc agcagcgcgc gaataaactg ctgccgccgc 31140 cgctccgtcc tgcaggaata caacatggca gtggtctcct cagcgatgat tcgcaccgcc 31200 cgcagcataa ggcgccttgt cctccgggca cagcagcgca ccctgatctc acttaaatca 31260 gcacagtaac tgcagcacag caccacaata ttgttcaaaa tcccacagtg caaggcgctg 31320 tatccaaagc tcatggcggg gaccacagaa cccacgtggc catcatacca caagcgcagg 31380 tagattaagt ggcgacccct cataaacacg ctggacataa acattacctc ttttggcatg 31440 ttgtaattca ccacctcccg gtaccatata aacctctgat taaacatggc gccatccacc 31500 accatcctaa accagctggc caaaacctgc ccgccggcta tacactgcag ggaaccggga 31560 ctggaacaat gacagtggag agcccaggac tcgtaaccat ggatcatcat gctcgtcatg 31620 atatcaatgt tggcacaaca caggcacacg tgcatacact tcctcaggat tacaagctcc 31680 tcccgcgtta gaaccatatc ccagggaaca acccattcct gaatcagcgt aaatcccaca 31740 ctgcagggaa gacctcgcac gtaactcacg ttgtgcattg tcaaagtgtt acattcgggc 31800 agcagcggat gatcctccag tatggtagcg cgggtttctg tctcaaaagg aggtagacga 31860 tccctactgt acggagtgcg ccgagacaac cgagatcgtg ttggtcgtag tgtcatgcca 31920 aatggaacgc cggacgtagt catatttcct gaagcaaaac caggtgcggg cgtgacaaac 31980 agatctgcgt ctccggtctc gccgcttaga tcgctctgtg tagtagttgt agtatatcca 32040 ctctctcaaa gcatccaggc gccccctggc ttcgggttct atgtaaactc cttcatgcgc 32100 cgctgccctg ataacatcca ccaccgcaga ataagccaca cccagccaac ctacacattc 32160 gttctgcgag tcacacacgg gaggagcggg aagagctgga agaaccatgt tttttttttt 32220 attccaaaag attatccaaa acctcaaaat gaagatctat taagtgaacg cgctcccctc 32280 cggtggcgtg gtcaaactct acagccaaag aacagataat ggcatttgta agatgttgca 32340 caatggcttc caaaaggcaa acggccctca cgtccaagtg gacgtaaagg ctaaaccctt 32400 cagggtgaat ctcctctata aacattccag caccttcaac catgcccaaa taattctcat 32460 ctcgccacct tctcaatata tctctaagca aatcccgaat attaagtccg gccattgtaa 32520 aaatctgctc cagagcgccc tccaccttca gcctcaagca gcgaatcatg attgcaaaaa 32580 ttcaggttcc tcacagacct gtataagatt caaaagcgga acattaacaa aaataccgcg 32640 atcccgtagg tcccttcgca gggccagctg aacataatcg tgcaggtctg cacggaccag 32700 cgcggccact tccccgccag gaaccatgac aaaagaaccc acactgatta tgacacgcat 32760 actcggagct atgctaacca gcgtagcccc gatgtaagct tgttgcatgg gcggcgatat 32820 aaaatgcaag gtgctgctca aaaaatcagg caaagcctcg cgcaaaaaag aaagcacatc 32880 gtagtcatgc tcatgcagat aaaggcaggt aagctccgga accaccacag aaaaagacac 32940 catttttctc tcaaacatgt ctgcgggttt ctgcataaac acaaaataaa ataacaaaaa 33000 aacatttaaa cattagaagc ctgtcttaca acaggaaaaa caacccttat aagcataaga 33060 cggactacgg ccatgccggc gtgaccgtaa aaaaactggt caccgtgatt aaaaagcacc 33120 accgacagct cctcggtcat gtccggagtc ataatgtaag actcggtaaa cacatcaggt 33180 tgattcacat cggtcagtgc taaaaagcga ccgaaatagc ccgggggaat acatacccgc 33240 aggcgtagag acaacattac agcccccata ggaggtataa caaaattaat aggagagaaa 33300 aacacataaa cacctgaaaa accctcctgc ctaggcaaaa tagcaccctc ccgctccaga 33360 acaacataca gcgcttccac agcggcagcc ataacagtca gccttaccag taaaaaagaa 33420 aacctattaa aaaaacacca ctcgacacgg caccagctca atcagtcaca gtgtaaaaaa 33480 gggccaagtg cagagcgagt atatatagga ctaaaaaatg acgtaacggt taaagtccac 33540 aaaaaacacc cagaaaaccg cacgcgaacc tacgcccaga aacgaaagcc aaaaaaccca 33600 caacttcctc aaatcgtcac ttccgttttc ccacgttacg tcacttccca ttttaagaaa 33660 actacaattc ccaacacata caagttactc cgccctaaaa cctacgtcac ccgccccgtt 33720 cccacgcccc gcgccacgtc acaaactcca ccccctcatt atcatattgg cttcaatcca 33780 aaataaggta tattattgat gatgtaggga taacagggta at 33822 <210> 76 <211> 34723 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO168) <400> 76 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgcctt aatgaacgga actactcaga acaacgctgc gctttttgat ggaggggttt 3660 ttagccctta tttgacttcc aggttaccat attgggccgg agtacgtcag aatgtggtag 3720 gatctacagt ggacggtcga cctgtggcac ctgcaaattc atcaacatta acctatgcaa 3780 ctattggacc ctcgcctttg gataccgccg ccgccgctgc agcttccgcg gccgcttcta 3840 cggctcgcag tatggcagct gatttcagct tctacaatca cttggcttcg aatgctgtga 3900 cacgcaccgc agttcgagag gacattctga ctgttatgct tgccaagctt gaaactctaa 3960 ctgctcagct ggaagagcta tcgcaaaagg ttgaggaatt agctgatgct actacccata 4020 ccccagccca acctgtaacc caataaaaca taaataaaaa accagactct gtttggattt 4080 ggatcaagca agtaaattga gatggtgtta tgaatcttta ttgatacttg ttttttctga 4140 catggtaagc tcttgaccac cgttccctat cattaagaac acggtgaatg tgttccagta 4200 ttttgtaaag atgagcctgt atattaaggt acattggcat taggccatct ttgggatgaa 4260 ggtaggacca ttgaagggct tcatgttccg ggttagtgtt gtagataatc cagtcatagc 4320 aacaacgctg ggcatggtga ttaaatatat cttttaacaa caagctaatt gctaatggaa 4380 gacctttagt ataggtattg ataaaacggt taagctgggt gggatgcatc cgaggtgaca 4440 tgatatgaag ttttgattgt attttgagat tggcaatgtt acctgccaaa tctcttcttg 4500 gattcatatt gtggagaacc acgaaaacgg tgtagccagt acacttggga aatttgtcat 4560 ggagtttaga aggaaaggca tggaaaaact tggaaacgcc tttgtgactt cccaaatttt 4620 ccatacactc atccattatt atggcaattg gaccgcgagc agcggcttga gcaaaaatgt 4680 tttctggatc agaaacatca tagttgtggt ctagagttag gtcatcgtag gacaacttaa 4740 caaatttagg acacagcgtt ccagattgtg gaataatagt tccctctggt cctgggacat 4800 aatttccctc acaaatttgc atttcccaag atttaatttc agatggggga atcatgtcca 4860 cttgcggaac aataaaaaaa acagtttctg gagcaggtgt aaccagctgg gcagaaagca 4920 aattacgcaa caactgagac ttcccacagc cagtgggtcc ataaattacc ccaattacag 4980 gttgcaagtg atagtttaac gaggtgcagc tgccgtcttc gtggagaagc ggagccactt 5040 cattcatcat ttgtcggacg cggatgtttt gcttggccag ttcccctaac agacgctctc 5100 cgcctaagga aagtaactct tgtaaagatt tgaaattttt aagtggcttt aggccatcgg 5160 ccataggcat gtggtccagg gtttgcttca gcagttgcaa gcgatcccat agctcagtta 5220 tattttctat gccatctcga tccagcaaac ttcctcgttg cgggggtttg gctggctgtt 5280 gctgtaagga acgaggcggt gagcatccaa atggacgagg gttttgtcct tccagggacg 5340 taatgtgcgc gtcagggttg tttcggtcac ggtgaatgga tgcgctcctg gttgagcgct 5400 ggccagtgtg cgctttaaac tgaggcggct ggtgctgaag cgcgtgtctt ctccctgtgc 5460 ttcggcaagg tagcatttta acataagatc ataagacaaa gcctctgtag cgtggccttt 5520 agcccgtatt tttcctttgg aggtgctccc gcagtgagga cactgaaggc atttaagggc 5580 gtacagtttt ggagccaaaa aaacagattc tggagaataa gcatctgcgc cacaataact 5640 acaaacagtt tcacattcaa ctgaccaggt cagctcagga catgatggat caaaaacaag 5700 tttccctccg tactttttga tgcgtttctt accttgcgac tccataaggc ggcgtccttt 5760 ctctgtgaca aaaagactgt cagtgtctcc gtatacagat ttaaggggtc tatccttcag 5820 tggtattccg cggtcctcct cgtacaggaa ttctgaccac tctgacacaa aagctctagt 5880 ccaagcaagt acaaaggaag ccacatggga agggtaccga tcgttgttaa ttaaagggtt 5940 agaactttct aaggtgtgta aacacatgtc tccttcttca gcgtccatga atgtgattgg 6000 tttgtaggtg taagtcacgt gttcacaatt ttctggtggt gggctataaa aaggggcggg 6060 tccttggtct tcatcgcttt cttctgcttc gctgtttacg agcgccaact ggttgggtga 6120 gtacacgcgc tcaaaggcag gcattacctc tgtactcaac gtgtcagttt ctataaacga 6180 tgaggatttg atgtttaatc gccccgctgc aatttctttc attaggcttt cttccatttg 6240 atcagaaaaa actatttttt tgttatctag tttggtagca aaagatccgt acaaggcatt 6300 ggaaagcagc ttggctatag atcttagggt ttgatttttg tccctatcgg cccgttcttt 6360 tgcggcaata ttgagttgca catattcgcg tgccaggcat ttccaggtgg ggaaaatggt 6420 ggtgcgctcg tcagatagca agcgtaagcg ccacccgcga ttatgcagtg taaccagatc 6480 tacgctggta actacttcac cgcgcaagct ttcattggtc caggctaaac gaccgccttt 6540 tctagaacaa aaaggaggaa gaacatccaa ctgattttca tctggggggt cggcatctat 6600 agtaaaaatg ccaggacaaa gatttttgtc aaaataatca attttgcaag tgtaattttc 6660 cagcgccacc tgccattgcc gcacggccaa tgcccgctca taggggttaa ggggaggacc 6720 ccaaggcatg gggtgtgtga gggccgatgc atacatgccg caaatatcat atacatatat 6780 gggctctttt agtactccta tgtaagtagg atagcacctg ccgccacgaa tgctggcgcg 6840 aacgtagtca tatagctcat gtgaaggcgc caggatgttg ggcccaagat gtgtgcgctg 6900 tggtttttcg gcgcggtaca aaatttgtct gaaaattgca tgagagttag aggaaatggt 6960 aggacgctga aacacattaa aatgtgccgc gtcaagaccc actgcgtcag taacaaactg 7020 ggcgtatgag ctacgcagtt tttctaccaa tgaggcagtc acaagtacat ccagggcaca 7080 atagtttaat gtttccccga taagattgta atttttttct cctttttttt tccatagttc 7140 ttgatttagg aggtattcct ccttatcctt ccagtactcc tccaggggaa acccatttgc 7200 atctgcacgg taagaaccaa gcatataaaa ctgatttacc gccttgtacg gacaacatcc 7260 tttttctaca ggcagggcat acgcttgtgc agcctttctt aaagatgtat gagtaagagc 7320 aaaggtatct ctgaccatta cttttaaata ctggtattta aaatcttggt cgtcacaccc 7380 tccgtgttcc cacagtagga agttagttcg ctttttgtag tggggattgg gaagggcaaa 7440 agtaatatca ttaaataata ttttgccagc tcttggaata aaatttctag aaattttaaa 7500 gggtccaggg acgtccaagc ggttattgat tacctgagcg gcaagaacaa tttcatcaaa 7560 tccattaata ttgtgtccta ctatatacaa ctctacaaat cttggctcac ccttaattgc 7620 aggggctctt ttaagatctt cgtaggaaag atcttcaagc gcgactagtc cgttttcttc 7680 ttgagcccat tgagacaagt gtggattttt ttgtaaaaaa gtcatccaaa gatcagtagc 7740 taaggaggtt tgtaagcggt ttctataggt acgaaactgt tgaccgacct tcattttttc 7800 tggggttaag cagtagaaag tagtagagtc tttttcccat tggtcccatc caagttctaa 7860 tgcaagttgt aaggcatgtt tgacaagatt gtcatcccca gacagtttca tcaccagcat 7920 aaatgggaca agttgctttc caaatgcccc catccaggtg taggtttcta catcataggt 7980 aataaaaagg cgctcagtgc gaggatgcga accgattggg aaaaagtgga tctcctgcca 8040 ccagttggaa gaatggctgt tgatgtgatg aaagtagaaa tctcgtcggc ggacagagca 8100 ttcatgctga tgtttgtaaa agcgtgcgca gtgttcgcat cgttgcacgg gctgtatctg 8160 ttgaatgagg tgtacctggc ggcctcgcac cagaaagcag atgggaaaat caataccact 8220 tggcagctgc cgttcgtcct cttcctcttc tgctgcattg ccactaccgt ttggatcctc 8280 gaaagcgaga acggagaggg tgacggtgcc cctcgacctg catgtccaga tttcagcacg 8340 agaggggcgg aaacgggaaa tcagggcgta cagcctggag ctgtccatgg tatcagtcag 8400 agagaaaagc atgtccgcgg ggacagcgcg caagttgact tcgcacaggc gggtaagagc 8460 aggctggagg tgcaggtaat acttaatttc tagaggcgtg ccgttggcag agtctattgc 8520 gtgaagtatt ccatgagccc ggggactaac cacggttcca cggtgcactt ttccaatgcg 8580 cctgcttaaa atcggcggcg cggacgagct cccggaggaa gcggcggttc gggtcctgcg 8640 ggaagcgggg gaagcggtat gtcggcctga cgctctggca ggggaaggtg ttgagcccga 8700 agttgactgg catgggcgac tacccggcga ttgatatctt gaatctgtcg gcgttgtgta 8760 aacactaccg gccctgttgt tttgaacctg aaagaaagtt caacagaatc aatctcagtg 8820 tcatttactg cagcctgtct taaaatctcc tgaacgtcgc ctgagttatc ttggtaggca 8880 atttctgcca ttaattgatc aatttcttcc tcctggaggt ctccatgtcc cgcacgttca 8940 atagtggctg caaggtcatt agatatccga ctcataagct gtgaaaatgc gtttagtcca 9000 atttcgttcc agactcggct gtatactacc cctccttcgc tgtcccgagc gcgcataacc 9060 acttgcgcca agttgagttc cacgagccgt gcgaacacgc cgtagttgcg caagcgctga 9120 aacaggtagt ttaaggtggt ggcaacgtgt tctgagacga agaaatacag aatccaccga 9180 cgaagcgtca gctcgttgat gtcacctaag gcttcaagac gttccatggc ttcgtaaaag 9240 tctactgcaa aattgaaaaa ctgggagttg cgagctgcca ccgtcaattc ttcttccaac 9300 agacgaataa gctcggccac cgtctcgcgc acttcttgct gaaatgcgcc cggaactatt 9360 tcttgttctt cctcttctac ctccattatt tcttcctcga ccacaggtgg tgggggttgt 9420 cttcttcgac gccggcgaac gggcagcctg tctacaaatc tttcaatcat ttcgccgcga 9480 cggcggcgca tagtttcggt tactgctcga ccgttttcac gtggtcgtaa ctcaaaaact 9540 ccacctctaa gttctgtttc atgtaaaatg ggaaatgagg cgttgcgagg ggcgttaggt 9600 agggatacag cgctgattat gcattttatt atttgctgcg taggaactcc gcgcaaggag 9660 ctaagcgtct gcatatccac cgggtcggag aacctttcaa gaaaggcatc tagccagtca 9720 cagtcacaag gtaggctaag ttttgtttct tctaaagtac caggaagctg agcaatgcta 9780 ctaataatgt aattgaagta agctgtttta agcccacgaa tggttttaag aagcaccaca 9840 tctttgggtc cggcttgttg aattcgcagg cggtctgcca ttccccacac gtcactttga 9900 catcgtccaa gatctttgta gtagtcttgc attaaccttt ccacctctac ctcgcggttt 9960 ccgcgatcag ccatgtgcgt gcttccgtag ccttgcagcg gttgtaataa agctaaatct 10020 gccactaccc gttccgcaag cactgcctgt tgaatttggg taagggtggt tgcaaagtca 10080 tccacatcta caaagcggtg ataagctcct gcattaatgg tgtagctgca gtttgtcatt 10140 actgaccaat taacagtttg cgtgcctggc tgtacagttt ctgtgtatcg caagcgtgag 10200 taagcccgag agtcaaaaac atagtcattg caggtgcgca ctaggtattg atagcccaca 10260 aggaaatgag gaggaggttc gcgatacaac ggccagccaa gcgtagccgc agcacctgga 10320 gcgagatctt ccaacatgag gcggtggtat tcatatatgt atctggacat ccatgtgatg 10380 ccggcagcgg tagttgttgc tcgcataaat tcgcgggctc ggttccaaat attgcgcagg 10440 ggtaaaaagc gttcaatagt tgccacgctt tgaccggtca ggcgtgcgca gtcttgaatg 10500 ctctggacat ggaaaaaatg aaagttggta agcgactccc ttccgtggtt tggtggaaaa 10560 gtcacaaggg taccatagcg aggaaccccg gttcgaaacc ggcaggatcc gctatgagca 10620 caagtgaggc gcttgcgcgt tgaacccggc caaggacccc cagacacgga gaggagtctt 10680 tttttattta ttttttctta gatgcatcct gtcctgcgac aaatgcgacc tcagcccagg 10740 gcaaccacgg cctcagcagc ggtggcgctt tcgggctctg gcgaacagga agagcctcaa 10800 tgtcctacat tggagttgga agaaggagaa ggcatagccc gattgggcgc ccactctcct 10860 gagcgtcacc caagggtgca gctcgcccgg gacagtcgcg tggcatttgt gcctcgtcag 10920 aacatgtttc gcgacaacag cggggaggaa gctgaggaaa tgcgagactg caggtttagg 10980 gccggtcgcg agctgcgccg cggatttaat cgcgagcgac tgctgcgtga ggaggacttt 11040 gagccagatg aacattcggg gattagttct gcacgggccc atgtatcagc agccaactta 11100 gtaacagcat atgaacaaac ggttacagag gaacgtaact ttcaaaaaag ctttaataac 11160 catgtgcgca cactaatagc gcgagaagaa gtagccattg gtttaatgca tctttgggac 11220 tttgtagaag cttatgtaca taatccagca agtaaacccc taactgccca gctgttctta 11280 atagttcaac atagtagaga caatgaaact tttagggatg caatgcttaa catagctgaa 11340 ccccagggtc ggtggttact cgatttaatt aacattctgc agagcattgt ggttcaggaa 11400 cgcagtctta gtttggcaga caaggtggcc gccattaatt actccatgtt aagtttggga 11460 aagttttatg ctcgtaaaat ctacaaaagt ccgtatgttc ccattgacaa ggaagtgaag 11520 atagacagct tttatatgcg catggcttta aaggtactaa cattaagcga cgatcttgga 11580 gtgtaccgca atgaccgaat ccacaaagca gtaagcgcca gtcgccgcag agagctaagc 11640 gacaaagagc ttatgcatag cttacaaagg gcgctgacgg gagcaggaac agaggacgag 11700 tcgttctttg atatgggcgc agacctacgg tggcagccaa gcgctcgcgc tttggaggca 11760 gctggagtgg cgtctgctga cgtcactggc gatgacgatg acgaagacca gtacgaggac 11820 tgatcggccg taccttttgt tagatgcagc gaccggcgat catcgcggag agggctccta 11880 acctggatcc cgcggttttg gcggccatgc aaagccagcc ttctggcgtt acagcttcag 11940 atgactggac agcggccatg gatcgtatta tggctttaac ggcgcgcagt cctgatgctt 12000 ttcgccagca gccccaagct aaccgctttt cggccatttt ggaagcagta gtgccgtctc 12060 gtactaaccc tactcacgag aaagtgttaa ccattgtaaa tgctttgttg gatagcaaag 12120 ccatccgcaa agatgaggct ggtttaatat acaacgcttt gcttgagcgc gtggcacgct 12180 ataacagtac caatgtgcag gctaacttag accggatggg tacagatgta aaggaggcgc 12240 tggctcaacg agagcgcttt catcgcgatg gtaatcttgg ttcgctagta gcattaaacg 12300 cttttttgag tactcagccg gctaatgttc cgcgtggtca ggaagattat acaaacttca 12360 tcagcgcctt gcgactaatg gttactgaag tgcctcaaag tgaagtgtat cagtctggac 12420 ccgattactt ttttcaaacg tccaggcagg gtttgcaaac cgtaaactta actcaggctt 12480 ttaaaaattt gcaaggtttg tggggggttc gtgctccagt aggcgatcgt tcaactttgt 12540 ccagtttact aacaccaaac tcgcgcctat tactgttgct aattgccccc tttaccaaca 12600 ccaacagttt aagtcgagat tcatacctgg gtcacttagt tactttgtac cgcgaagcca 12660 ttggtcaagc gcaggtagac gaacaaactt atcaagaaat aaccagtgtt agtcgcgcac 12720 tgggccagga ggacactggc agtttagagg ccacacttaa ctttttacta actaaccgtc 12780 gccagcaagt gcctcctcag tacactttaa atgcggaaga agaacgcata ttgcgctatg 12840 tacagcaatc tgtaagtttg tatcttatgc gtgagggtgc cacccccagt gccgccttag 12900 acatgacagc gcgcaatatg gagccgtcct tctacgcttc caatcgagct ttcattaatc 12960 gcttgatgga ttaccttcac cgcgctgcgg ccatgaacgg ggaatacttt acaaatgcaa 13020 ttctaaatcc gcattggttg ccccctcctg gattttacac tggtgaattt gatttgccgg 13080 aaggaaatga tggctttttg tgggatgatg ttacggacag tctgtttagt cctgcagtta 13140 ttggacacca tggtaaaaag gaagcaggtg atgaaggtcc cttgcttgac tctcgggcga 13200 gttctccatt ccccagttta actagtttac ccgccagtgt taacagcggt cgtaccacca 13260 gaccccgact aacaggtgaa agtgaatact taaatgaccc catcttgttt ccagtgcgcg 13320 acaaaaattt tcccaacaat ggcatagaaa gtttggtaga taaaatgtct cgctggaaaa 13380 catatgcaca agagcggcga gaatgggagg aaagacagcc aagaccagtt cgccctccta 13440 ggcaacgttg gcagcgacgc aaaaaagggg cacatgcggg ggatgaagga agcgatgact 13500 cagctgacga cagtagtgta ttagatttag gagggtcagg aaacccattt gctcatttgc 13560 gcccacaggg ttgcataggg tcattgtatt aaattgaata aaagcatact taccaaagcc 13620 atggcgacca gtgttcgtct tattttcctt cttccgttag ctgtgaaatg aggcgcgcgg 13680 tggaactgca gacagtggct tttcctgaga caccacctcc ctcttacgaa accgtgatgg 13740 cagcggcgcc accctacgtg cctccccgct atttgggtcc tacggaggga agaaacagta 13800 tccgttactc ggaattgtca ccgttgtacg ataccactcg agtgtacttg gtggacaaca 13860 agtcttctga cattgcttca ttgaattacc agaatgatca cagcaacttt ttaaccactg 13920 tagtgcaaaa taatgactat tcccctatag aggctggcac gcaaactatt aactttgatg 13980 aaaggtctag atggggtgga gatttaaaaa ccatcttaca taccaacatg ccaaacgtga 14040 acgattttat gtttaccacc aaatttaagg ccagggtaat ggtggctagg aaaacaaaca 14100 acgaaggcca aaccatttta gaatatgagt gggcagaatt tgtgctaccc gagggtaact 14160 attcggaaac catgactatt gacttaatga acaatgctat tattgagcat tatttgcgag 14220 taggaagaca gcatggagtg ctggaaagtg acattggagt taagtttgac accagaaact 14280 ttcgtctggg ttgggacccc gaaacccaat tagtaactcc gggagtgtac actaatgagg 14340 cttttcatcc agatatagta ctgcttccag gttgcggggt tgattttaca gagagcagat 14400 taagcaacat actaggtata agaaagaggc agccgtttca ggaaggattt gtgattatgt 14460 atgaacactt agagggaggc aatattccag ctcttttgga tgtaaaaaaa tacgaaaaca 14520 gtctgcagga tcaaaacact gtaagaggag acaactttat tgccttaaat aaggctgcta 14580 ggattgaacc ggttgaaaca gaccccaaag gacgcagtta caacttgctt ccagacaaaa 14640 aaaatactaa atatcgcagc tggtatttgg catacaacta cggagaccca gaaaaaggag 14700 ttcggtcatg gactctacta acaactccag atgtaacagg cggctccgaa caggtgtact 14760 ggtccctacc cgatatgatg caagatccgg tgacttttcg ctcctcgcgt caagttagca 14820 actatcctgt agttgcagca gaattactgc cagttcatgc taaaagcttc tacaacgagc 14880 aagccgtcta ctcacagctt attcgccagt caaccgcgct tacgcgcgtg tttaatcgct 14940 ttcccgagaa ccagatactg gtgcgtccac cagccgctac catcactacc gtcagtgaaa 15000 acgttcccgc ccttacagat cacgggaccc tgccgctgcg tagcagtatc agtggagttc 15060 agcgagtcac catcactgac gcccgccgcc ggacctgtcc ctacgtttac aaagcactgg 15120 gcatagtttc tccacgagtg ctttctagtc gcacttttta aaaaagtgtg gtaacatgtc 15180 cattttggtt tcgccaagta acaacacggg ctggggactg ggtgccgccc gcatgtatgg 15240 aggagctaaa acaaggtcta gccaacatcc agtgcgcgta cgcggacatt accgagctcc 15300 atggggcgcg catacccgag gacgcactgg tcgcaccact gtagacgatg ttattgactc 15360 ggtagtggcc gatgctcgca agtaccgcgc gcccgctgaa acagcagggt ctactgttga 15420 tgcagtaatt gatgaggtag tggcaaacgc gcgggcttat gcaaggcgcc gcagacggct 15480 gcgtcgccgg cgtagaccaa ccaccgccat gcgcgcggcc agagcgttgg ttcgacgggc 15540 caggcgcatt gggcggcgag ctatgatgcg ggcagccagg cgggctgcaa cgcctgccgg 15600 tcgagcgcgg agacgggccg cagctgcggc cgcaacagct attgcaaacc tagctgctcc 15660 gcgacgagga aatgtatact gggtgcgcga ctcagtgacc gggacgcgtg tgccagttcg 15720 tacgcgtcca cctcaccctt agaagacaaa gagtgactca atgtctgtta tgtatgccca 15780 gcatgaccaa acgcaagttc aaagaagagc tgctgcaggc cttagcgcct gaaatatatg 15840 gcccatcgga taaccttacc aagcgcgata tcaagcatgt taaaaaacgg gaaaaaaaag 15900 aggaagaagt cgccgcggcg tcagcagacg gcgtcgagtt tgtgcgctca tttgcgccca 15960 gacgtagggt acagtggaag ggacggcaag taaaacgcat tttgcgaccg ggcaccacag 16020 tggttttttc tcccggagag cgaacgatta tgcgtcccct aaagcgcgag tacgacgaag 16080 tgtacgcaga cgatgacatt ttggagcaag cggcacaaca gactggggaa tttgcatatg 16140 gaaaaaaagg gcgttacgga gacaaaattg ctattccttt ggacgaggga aatccaacac 16200 ccagtttaaa ggctgtcact ttgcaacaag tgttgcccgt ccttgggcct tcggaagaaa 16260 agcgtggaat taaaagggaa gccatggatg aattgcagcc tacaatgcaa ctgatggtgc 16320 ctaagcggca aaagttagag gacgtactag agcacatgaa ggtggatcct agcgtacagc 16380 cagatgtaaa agtacgtccg ataaaaaagg tagctccagg attgggagtt caaacagtgg 16440 acattcaaat tcctgtgcaa actgcattgg gtgaaactat ggaaatccaa acttcgccaa 16500 taaaaacaac ggtgaacgca agcgtgcaaa cagacccttg gtacccgcca gtgctttcaa 16560 caaaaaaaaa gcgtcactac agacaaacaa gttcgctttt gccagactac gttttacatc 16620 cttccattgt gcccacgcct gggtaccgtg ggacaacttt tcagcgccga gccacagccc 16680 ctagccgtag acgaggtcca tcacgccgta gacgtcgacg caaagccact ttagccccag 16740 cggcagtacg tcgcgttgta caaagggggc gcacactaat acttccatcc gtgcgttacc 16800 accctagcat tctctaacaa gctgcgctgc cgttttttca gatggctctt acttgccgaa 16860 tgcgcatacc cattccagga tacagaggac gaccccgccg gaggaaaggg ctgaccggga 16920 acggtcgatt tcggcggcgt agtatgcgca gacgcatgaa gggtggggtg ctgcccttcc 16980 taattccact tattgctgcg gccattggag ccgttcccgg aattgcctca gtagccttgc 17040 aggcttctcg aaaaaattaa aataaaataa aacttccaac ttattactgg tactatgact 17100 gttttatgca gactaaatgg aagacatcaa tttttcgtcg ctggccccgc gacacggcac 17160 gcggccgtac atgggcacct ggaacgagat cggcacgagc cagctgaacg ggggcgcctt 17220 caattggaac agtatctgga gcggtcttaa aaattttggt tccacgatta agacatatgg 17280 caccaaggcg tggaacagcc aaaccggcca gatgctaagg gacaagttaa aagaccaaaa 17340 ttttcaacag aaagttgtag atggtctggc ttcgggaatt aatggagttg tagacatagc 17400 caatcaggct gtacagaaaa aaattgccaa ccgtttagag ccgcggcccg acgaggtaat 17460 ggtagaggaa aagctgccac ctctagaaac tgtgcccgga tccgttccaa ccaaaggaga 17520 aaagcggcca cggccggatg cagaggaaac cttagtaacg cacacaacag aaccgccgtc 17580 ctatgaggaa gcaataaaac aaggagccgc tctgtcacct accacctatc ccatgaccaa 17640 gcctatttta cccatggcta ctagagtgta tggaaaaaac gaaaatgtgc ctatgaccct 17700 tgagctgcct cctttgccag aacccactat cgcggatccc gtaggttccg ttcctgttgc 17760 atctgttcca gttgcatcga cagtgagccg tccagcagtg cggcctgttg ccgtggctag 17820 cttgcgaaac ccacgatcca gtaattggca aagtacccta aacagtattg tgggactggg 17880 agtaaagtct ctcaaacgcc gacgctgcta ctaacattaa aagacgagtg ttaattccca 17940 tctgtgtata cgcctcctat gttagcgcca gaggaccaac gcgtgaatcg cagtcaccac 18000 cagcgctttc aagatggcca ctccctcgat gatgccgcag tggtcttaca tgcacatcgc 18060 cggtcaggat gcctcggagt acctgagtcc cggtctggtg caattcgccc gcgccacgga 18120 cacctacttc accctgggaa acaagtttag aaaccccacc gtggctccca cccatgatgt 18180 taccaccgat cgctcgcagc gtctgacgct gcgttttgtg cccgtggatc gggaagatac 18240 tacctactcc tacaaggctc gctttacgct ggctgtgggt gacaaccgcg tgttagacat 18300 ggctagttct tactttgaca ttcgaggggt actggatcgt ggtcccagtt ttaagcccta 18360 ttccggaacc gcctacaatt ctttggcacc aaaaggcgct cctaatgctt cacaatggtc 18420 agataacgct aagcttaata cctttgctca ggcgccgtat cttagcgaca ctatcaccgc 18480 cgccgatggt attaaagttg gaacagacac cgcccaggca ggcgcggcgg tgtatgccaa 18540 caaaacttat cagccagagc cgcaagtagg accaagtgaa tggaacacca gcattgaaaa 18600 cgttaaagct ggcgggaggg cattaaagca aaccactgca atgcagccgt gctatggctc 18660 ctacgctcgt ccaaccaacg aacacggagg acaatccaag gatgacaaca ttgaacttaa 18720 gttctttgat tcagctaaca atgcagcaaa cactgctcaa gttgtgttct ataccgaaga 18780 cgtaaacctt gaaatgccag acacgcatct tgtgtttaag cctactgtta ccaatggaac 18840 aattgcttct gagtcgctgt tgggacagca agcagcgcca aatagagcaa actacattgc 18900 attcagagat aattttattg gcctgatgta ttacaacagt acaggcaaca tgggtgtatt 18960 ggccgggcaa gcttcccaac ttaacgcagt agtagacctg caagacagaa atacagagct 19020 gtcataccag ttaatgctgg atgctttggg agacagaaca cggtactttt ccttgtggaa 19080 ttccgcagtg gacagttacg accctgacgt tcgcgttatt gagaatcacg gggtagagga 19140 tgaactacca aattattgct ttcctcttag cgcagtaggt gaaataaaaa attacaaagg 19200 cattaagcca gataacggag gaggaggtgg ctggactgcc gacaacactg tcagtgaagc 19260 aaaccacata ggcattggga atatagccgc catggaaatt aatttgcagg ctaatttgtg 19320 gagaagcttc ttgtactcaa atgtgggctt atacctacca gacgacttaa aatacactcc 19380 aggaaacata aaactacctg ataacaagaa cacctacgag tacatgaacg ggcgtgtgac 19440 tgccccgggg ttggtggata cctatgtcaa tatcggcgct cgctggtccc cagatgtgat 19500 ggataatgta aaccctttta accaccaccg aaacgcaggg ttgcgctaca gatccatgtt 19560 gctaggcaat gggagatttg ttccttttca cattcaggtg ccgcaaaaat tttttgccat 19620 cagaaatttg ttgctgttgc ccggttccta cacttacgaa tggcggttcc tacacttacg 19680 aatggaactt tagaaaggat gtaaacatga ttcttcagag cacactggga aatgatcttc 19740 gggtggacgg agccagcgtt cgctttgaca acattgccct gtatgctaac ttttttccca 19800 tggcacataa cacagcttct actttagaag ccatgttaag aaatgacacc aacgaccagt 19860 cttttaacga ttatttgtgt gctgcaaaca tgctgtatcc catcccagct aacgccacca 19920 gcgtgcccat ttcaatacct tcgcgaaatt gggcggcatt tagaggctgg agctttactc 19980 gcctaaaaac taaagaaact ccttccctgg gttcagggtt tgacccctac tttgtatact 20040 ctggaaccat tccctattta gacggcacct tttacctaaa ccacactttt aagaaggtgt 20100 caatcatgtt tgactcctcc gtgagttggc ctggaaatga ccgtttgcta accccaaatg 20160 aatttgaaat aaagcgttct gtggatgggg agggatacaa tgtggcccaa tgcaatatga 20220 ctaaggattg gttcctaata caaatgctta gtcattacaa cattggatac caaggttttt 20280 acattccaga gagctacaag gaccgcatgt attctttctt tagaaacttt cagcccatga 20340 gtaggcaagt tgtggatacc acagaatata agaactacaa aaaagtaacc gtagagtttc 20400 aacataacaa ctcaggattc gtgggatacc tgggccccac tatgcgggag ggacaagctt 20460 accccgccaa ctatccctac cctcttatag gccaaacagc tgtggaaagc atcacacaga 20520 aaaagtttct atgcgatcgt gttatgtggc gcatcccatt ttctagtaac ttcatgtcta 20580 tgggggcgct aacggatctt gggcaaaata tgctgtacgc aaactcagcc catgctctag 20640 acatgacatt tgaggtggat ccaatggatg agcctaccct tctttatgtt ttatttgaag 20700 ttttcgacgt ggtacgcatt caccagccac accgcggcgt cattgaagcg gtctacctgc 20760 gcacgccctt ctcggcgggt aacgctacca cctaagaagg caccctccca gactgctgta 20820 atgggttcaa gcgaacagga gctgacggcc attgttcgag atctaggctg tggaccctat 20880 tttttgggaa cctttgacaa acgttttccg ggttttgtgt ctcgcgaccg cttatcatgt 20940 gctattgtta acactgccgg tcgcgaaact gggggcgtac actggctggc ttttggatgg 21000 aaccccaaat cgcacacttg ctatttattc gatccatttg gattttctga tcaacgacta 21060 aaacaaatct atcagtttga gtacgaaagt ctgttgcgcc gtagtgcgct agcggccact 21120 aaagaccgat gcgttaccct agaaaagtca acccaaactg tacaaggacc gttttctgca 21180 gcgtgcggcc tgttttgttg tatgttctta cacgctttta ctcactggcc tgaccatcca 21240 atggataaaa atcccactat ggacctactt actggggtgc ctaattgtat gctacaaagt 21300 cctcaggtag tgggcacatt gcaacgcaat cagaatgaat tgtataaatt cttaaacaat 21360 ctgtcccctt actttcgtca caaccgcgag cgcatagaaa aagctacatc ttttactaaa 21420 atgcaaaatg gactcaaata aacgtgtaca caatgcatta ataataaaac cattttatta 21480 gctcattgga gtacaagctt gactgtttta ttaaaaatca aatggctctt cgcgacagtc 21540 gccgtggttg gtgggcaggg atatgtttct gtactgcaaa cgctgatgcc acttgaattc 21600 tggaataaca agcctagggg gggagccgtc aaaattttct ccccacagct ggcgcacaag 21660 ttgcagggcg cccataacat caggagcaga aatcttgaag tcgcaattag ggccagcatt 21720 gccgcgcgca ttgcgataaa ctggatttgc gcactgaaaa accaacaaac acggatactt 21780 aatactggct aacgctccag ggtcggttac ttcgttgata tcaatgttat ccacattgct 21840 gaggttaaaa ggagtgattt tacacagttg acgccccatc cgtggcaggc catcttgctt 21900 gtttaaacat tcgcagcgca ctggcataag gagacgtttt tgcccatgtc gcatgtgagg 21960 gtagtcggcc agcataaaag cttcaatttg cctaaaagct atttgagcct tcattccttc 22020 agaataaaac aagccgcagg actttccgga gaaagaatta ttcccgcagc caacatcatg 22080 aaaacagcag cgggcatcgt cgtttttaat ttgaactaca ttacgccccc agcggttttg 22140 cgccaccttg gctttcgagg ggttctcttt caacgctcgt tgcccacttt cgctggttac 22200 atccatttcc accaaatgct ctttgcgcac catctccatt ccatgcaggc atctaagctc 22260 cccttcgcgc tcggtacact tatgctccca cacgcagcaa ccggtgggtt cccaggaatt 22320 ctgttggaca ccggcataag cttgcatata tccttgcaaa aagcgtccca tgagctcctg 22380 aaaggttttt tgggatgaaa aagtcagctg caaaccgcgc ttttcttcgt tgagccatgt 22440 tgtgcatatt ttcttgtaca cgctgccctg atccggcaaa aaacgaaagg tggcgcgctc 22500 gtcgtgatcc acatggtact tttccattag catagccatg gcttccatgc ctttttccca 22560 agctgaaact aggggctggc ttgccggatt gcgaacaaca acaacattct tttcattttc 22620 gtcgctgttt tgagcggaag ccttcaaaac gtgtacctgc ctggtttcca ttttttgaaa 22680 agactgagaa ccgtctgcat gatgcataat gcggacgggc ggcatgctga aacccattac 22740 tcctaaaact gctcttggtg gttctgcctc ttcttcttct gcactctctg gggaaagagg 22800 tatcgcagcc atagatttct tgactttttt ctttggaggt aaaggcacag cttccagttc 22860 ttcttcgctt tcggaatcca gaaagtatct gcccattttt ggcggcggcg gctgagcgct 22920 gcggtctggg gtgcgctccc tctgtgagtg ctgattgctg gccattattt aatcctaggc 22980 aaagaaacac atgatggatc tggagccaca ggaaagctta accgccccca ccgctcccgc 23040 cattggcgct acggctgtca tggagaagga caaaagtcta ctcatacccc aagacgcacc 23100 ggttgagcag aacttgggct acgagactcc ccccgaggaa tttgaaggct ttcttcaaat 23160 ccaaaagcaa ccaaatgagc aaaacgctgg gctcgaggac catgactacc taaacgaggg 23220 agatgtcctg tttaaacatc tacagcgaca aagcactatc gttcgcgacg ccatatctga 23280 tcgctcttca ataccagttt caattgcaga actatcttgc atctacgaac gcaacctgtt 23340 ctccccacgt gtgcccccta aacggcaagc caacggcaca tgcgagccaa atcctcgcct 23400 taacttctac ccagtttttg cagtgccaga agcactggca acataccata ttttctttaa 23460 aaatcacaaa atacccctat cctgtcgagc taaccgcagc cgcgcagatg agcttcttgc 23520 tttaagggct ggcgcttcca tacctgggat tgtgtccttg gaagaggtgc ctaaaatttt 23580 tgaaggttta ggtcgggatg aaaaacgagc agcaaatgcc ctgcaaaaag aaaatgaaca 23640 aaatcaccat gggaatagtg ctctaataga actggaaggt gacaatgccc gcctggcagt 23700 tttaaagcgc aatattgagg ttactcactt tgcctacccg gcagtaaatc ttccgccaaa 23760 ggtaatgagc gcagtgatga atcagctact aattaagcga gcccaaccca ttgacaaaga 23820 tgcaaacttg caagacccgg aggcaacaga tgatggaaag ccggttgtaa gcgacgagca 23880 attaactaag tggttgggaa cagacaattc caacgaacta caacagcggc gtaaactcat 23940 gatggccgcc gtacttgtaa ctgtggaact cgagtgcatg catcgttttt tctccgacat 24000 caccacattg cgcaaaattg aggaatgtct tcactacact ttccgccatg gctacgtgcg 24060 ccaagcctgt aaaatttcta atgtggagct gagcaatcta gtttcttaca tgggcatctt 24120 gcatgaaaac cgattgggac agaacgtgct acactcaaca ctacgcgatg aagcacgcag 24180 agattacgtg cgagactgca tttacctttt cctgttacat acctggcaaa ctgggatggg 24240 tgtttggcag caatgcttgg aagaaaaaaa ccttcgagaa ctaaacaaac tgttagacag 24300 agcactaaaa tccctatgga ccggttttga cgaacggaca gtagctgcag agctagctga 24360 cataattttc ccagaaaggt taatgataac cttgcaaaac ggcttgcctg actttatgag 24420 tcaaagtatg ctgcacaatt atcgctcttt tatattagag cgttctggga tgcttcctag 24480 catgtgttgt gcacttcctt cagattttgt gcctatatat tttagagagt gcccccctcc 24540 cctgtggagc cactgctact tactacgact tgctaactac ctagcttacc actcagacct 24600 tatgacagat tcaagcggcg aaggcctaat ggagtgtcac tgccgctgca atctttgcac 24660 cccccaccgt tctttggttt gcaatactga actattaagt gaaagtcaag tcattggtac 24720 cttcgaaatg cagggaccgc agtctgacag caatttcacg acgaacctaa gacttacccc 24780 tgggctttgg acttctgcct acctgcgcaa atttgaaccc caagattacc acgcccacag 24840 tatcaatttt tacgaagacc aatccaaacc cccaaaagcg ccactaacgg cttgcgtcat 24900 tacgcaggga aaaattctag cccaattgca tgctattaag caagcgcgcg aagagttttt 24960 acttaaaaaa ggacacggag tgtaccttga tccccaaacc ggcgaggaac taaaccttcc 25020 atcacctttg tgtgctactg cgtctcccca ttcgcagcat gtccccgaaa gccgcaaaac 25080 aggctattgc gcagcaacgc tcaaagaaac agcagcaacg gcaggaaatc tgggaggaag 25140 aatcttggga gagtcaggca gaggacgagg tcgaggactt ggaagaatgg gaggaggagg 25200 aggcggacag cctagacgag gatccagagg aggaggagga aggttccaag gacggagcga 25260 ccgccgccaa accgtcgctt tcaaccaagc cctctccaat gaaacccgct gtgagcaaat 25320 ctcagaaagc caaccgtaga tgggacacca ttgaaaccag cgccgcaaac ttgggtaaga 25380 atcgcaagca ggcgcgtcgg ggctactgct catggcgggc tcaccaaagt aatattgtag 25440 cctgctttca gcactgcggg gggaatatct catttgcaag gcggtatttg ctataccatg 25500 atggagtggc gattccaagg aatgtcctcc attactaccg tcatctctac agcccctttg 25560 aagagctcga caaggaaccg acctgcaaca gccaagcggc ccactagaat cggcaacagc 25620 agcaacaagg aaagtcctga ggcgcgcgag ttaagaaaac gcatttttcc cactttatat 25680 gctatttttc agcagagtcg aggtcaagaa cacgaactga aaataaaaaa ccgttccctg 25740 cgttcactta cccgcagctg tctctacctc aaaagcgaag atcagttgca acgcaccttg 25800 caggacgcag aagctctgtt caataaatac tgctccctct cgcttaaaga gtaaaaaaag 25860 cccgcgcgcg gactttcaac aggcgggaaa agtgacgtca caacaagatg agtaaagata 25920 ttcccacgcc ttacatgtgg agctttcaac cccaaatggg actggcggcc ggcgcggctc 25980 aagactattc tagcaaaatg aattggttaa gcgccggacc ccacatgatt tccagggtga 26040 atggggtacg agcccggcgt aaccaaatac tgctagaaca agccgctctc accgctacac 26100 cacgtaatca acttaaccct ccctcttggc cagctgccct gatatatcag gaaaatcccc 26160 ctcctaccac tgtacttttg cctcgcgacg cccaggccga agtccatatg actaacgctg 26220 gggcacagct tgcgggcggt gcacgtcaca gtttcaggta taaaggtcgc actgagccct 26280 atccgtctcc agctataaaa agagtactca tcagagggaa aggtattcag ctgaacgacg 26340 aagtcacatc gccattggga gtcagacccg acggagtgtt tcagctcgga gggtccggac 26400 gttcctcctt taccgctcgt caagcctacc tgacactaca gagctcatcc tcagctccga 26460 gatctggtgg tattggaact ctccaatttg tggaggaatt tactccatct gtttacttca 26520 atcctttttc gggctcgcct ggacactatc ctgacgcctt catacccaac tttgacgcag 26580 tgagtgaatc tgtggatggc tatgattaag gatgttaagt ggagaggcag agcaactgcg 26640 cctgaaacac ctggtccact gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt 26700 ttgctacttt gaattgcccg aggatcatat cgagggcccg gcgcacggcg tccggcttac 26760 cgcccaggga gagcttgccc gtagcctgat tcgggagttt acccagcgcc ccctgctagt 26820 tgagcgggac aggggaccct gtgttctcac tgtgatttgc aactgtccta accctggatt 26880 acatcaagat ctttgttgcc atctctgtgc tgagtataat aaatacagaa attaaaatat 26940 actggggctc ctatcgccat cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa 27000 ggcgaacctt acctggtact tttaacatct ctccctctgt gatttacaac agtttcaacc 27060 cagacggagt gagtctacga gagaacctct ccgagctcag ctactccatc agaaaaaaca 27120 ccaccctcct tacctgccgg gaacgtacga gtgcgtcacc ggccgctgca ccacacctac 27180 cgcctgaccg taaaccagac tttttccgga cagacctcaa taactctgtt taccagaaca 27240 ggaggtgagc ttagaaaacc cttagggtat taggccaaag gcgcagctac tgtggggttt 27300 atgaacaatt caagcaactc tacgggctat tctaattcag gtttctctag aatcggggtt 27360 ggggttattc tctgtcttgt gattctcttt attcttatac taacgcttct ctgcctaagg 27420 ctcgccgcct gctgtgtgca catttgcatt tattgtcagc tttttaaacg ctggggtcgc 27480 cacccaagat gattaggtac ataatcctag gtttactcac ccttgcgtca gcccacggta 27540 ccacccaaaa ggtggatttt aaggagccag cctgtaatgt tacattcgca gctgaagcta 27600 atgagtgcac cactcttata aaatgcacca cagaacatga aaagctgctt attcgccaca 27660 aaaacaaaat tggcaagtat gctgtttatg ctatttggca gccaggtgac actacagagt 27720 ataatgttac agttttccag ggtaaaagtc ataaaacttt tatgtatact tttccatttt 27780 atgaaatgtg cgacattacc atgtacatga gcaaacagta taagttgtgg cccccacaaa 27840 attgtgtgga aaacactggc actttctgct gcactgctat gctaattaca gtgctcgctt 27900 tggtctgtac cctactctat attaaataca aaagcagacg cagctttatt gaggaaaaga 27960 aaatgcctta atttactaag ttacaaagct aatgtcacca ctaactgctt tactcgctgc 28020 ttgcaaaaca aattcaaaaa gttagcatta taattagaat aggatttaaa ccccccggtc 28080 atttcctgct caataccatt cccctgaaca attgactcta tgtgggatat gctccagcgc 28140 tacaaccttg aagtcaggct tcctggatgt cagcatctga ctttggccag cacctgtccc 28200 gcggatttgt tccagtccaa ctacagcgac ccaccctaac agagatgacc aacacaacca 28260 acgcggccgc cgctaccgga cttacatcta ccacaaatac accccaagtt tctgcctttg 28320 tcaataactg ggataacttg ggcatgtggt ggttctccat agcgcttatg tttgtatgcc 28380 ttattattat gtggctcatc tgctgcctaa agcgcaaacg cgcccgacca cccatctata 28440 gtcccatcat tgtgctacac ccaaacaatg atggaatcca tagattggac ggactgaaac 28500 acatgttctt ttctcttaca gtatgattaa atgagacatg attcctcgag tttttatatt 28560 actgaccctt gttgcgcttt tttgtgcgtg ctccacattg gctgcggttt ctcacatcga 28620 agtagactgc attccagcct tcacagtcta tttgctttac ggatttgtca ccctcacgct 28680 catctgcagc ctcatcactg tggtcatcgc ctttatccag tgcattgact gggtctgtgt 28740 gcgctttgca tatctcagac accatcccca gtacagggac aggactatag ctgagcttct 28800 tagaattctt taattatgaa atttactgtg acttttctgc tgattatttg caccctatct 28860 gcgttttgtt ccccgacctc caagcctcaa agacatatat catgcagatt cactcgtata 28920 tggaatattc caagttgcta caatgaaaaa agcgatcttt ccgaagcctg gttatatgca 28980 atcatctctg ttatggtgtt ctgcagtacc atcttagccc tagctatata tccctacctt 29040 gacattggct ggaacgcaat agatgccatg aaccacccaa ctttccccgc gcccgctatg 29100 cttccactgc aacaagttgt tgccggcggc tttgtcccag ccaatcagcc tcgcccacct 29160 tctcccaccc ccactgaaat cagctacttt aatctaacag gaggagatga ctgacaccct 29220 agatctagaa atggacggaa ttattacaga gcagcgcctg ctagaaagac gcagggcagc 29280 ggccgagcaa cagcgcatga atcaagagct ccaagacatg gttaacttgc accagtgcaa 29340 aaggggtatc ttttgtctgg taaagcaggc caaagtcacc tacgacagta ataccaccgg 29400 acaccgcctt agctacaagt tgccaaccaa gcgtcagaaa ttggtggtca tggtgggaga 29460 aaagcccatt accataactc agcactcggt agaaaccgaa ggctgcattc actcaccttg 29520 tcaaggacct gaggatctct gcacccttat taagaccctg tgcggtctca aagatcttat 29580 tccctttaac taataaaaaa aaataataaa gcttattact taccggaaat ctgaaaatac 29640 atcatggtct ccgtgtactc ttataaaatt tccctcttcc caactgtcaa acctgacaga 29700 cttgcaaaca gcaaactttc tccaaatctt aaatggaagg tcagattctt cttcccaatc 29760 cctacccacc atcttcatct tttctagatg aagcgcagca gaacccagta tgctgaagaa 29820 acagaagaaa atgatgactt caaccccgtt tacccttttg acccatttga cacatcagac 29880 gtaccctttg ttacaccccc ttttacttct tccaatggtc ttcaagaaaa accaccaggt 29940 gtattagcac ttaattacaa agaccccatt gtaactgaaa atggaaccct tacactcaag 30000 ctaggggacg gaataaaact taatgcccaa ggtcaactta cagctagtaa taatatcaat 30060 gttttggagc cccttaccaa cacctcacaa ggtcttaaac tttcttggag cgccccccta 30120 gcagtaaagg ctagtgccct cacacttaac acaagagcgc ccttaaccac aacggatgaa 30180 agcttagcct taataaccgc ccctcccatt acagtagagt cttcgcgttt gggcttggcc 30240 accatagccc ctctaagctt agatggaggt ggaaacctag gtttaaatct ttctgctccc 30300 ctggacgtta gtaacaacaa tttgcatctc accactgaaa ctcccttagt tgtaaattct 30360 agcggtgccc tatctgttgc tactgcagac cccataagtg ttcgcaacaa cgctcttacc 30420 ctacctacgg cagatccgtt aatggtgagc tccgatgggt tgggaataag tgtcactagt 30480 cccattacag taataaacgg ttccttagcc ttgtctacaa ctgctcccct caacagcaca 30540 ggatccactt taagtctgtc tgttgccaat cctctgacta tttcacaaga cacattgact 30600 gtttccactg gtaacggtct tcaagtgtcg gggtctcaat tagtaacaag aataggggat 30660 ggtttaacat tcgataatgg ggtcatgaaa gtaaacgttg ccgggggaat gagaacttct 30720 ggcggtagaa taattttaga tgttaattat ccctttgatg cgagcaataa cctgtcctta 30780 agacggggat tgggactaat ttataaccaa tctacaaact ggaacttaac aactgatatt 30840 agtaccgaaa aaggtttaat gtttagtggc aatcaaatag ctcttaatgc aggtcagggg 30900 cttacattta ataatggcca acttagggtt aagttgggag ctggacttat ttttgattca 30960 aacaataaca ttgccttagg cagcagcagc aacactccat acgaccctct gacactgtgg 31020 acaactcctg acccaccacc aaactgcagc ctcatacaag agctagatgc aaaactcacc 31080 ctgtgcttaa caaaaaacgg atctattgtt aatggcattg taagtttagt gggtgttaag 31140 ggtaatctcc taaatatcca aagtactact accactgtag gagtgcattt agtgtttgat 31200 gaacagggaa gattaatcac atcaacccct actgccctgg ttccccaagc ttcgtgggga 31260 tatagacaag gccaatcagt gtctaccaat actgttacca atggtctagg ttttatgcct 31320 aatgtgagtg cttaccctag accaaatgcc agtgaggcta aaagccaaat ggtaagtctc 31380 acgtacttac agggagatac atctaaacct ataacaatga aagttgcatt taatggcatt 31440 acgtcgctaa atggatactc tttaacattc atgtggtcag gtctatcaaa ctatataaat 31500 cagcctttct ctacaccatc ctgctccttt tcttacatta cccaagaata ataaagaatc 31560 gtttgtgtta tgtttcaacg tgtttatttt tcaattgcag aaaatttcga atcatttttc 31620 attcagtagt atagccccac caccacatag cttatacaga tcaccgtacc ttaatcaaac 31680 tcacagaacc ctagtattca acctgccacc tccctcccaa cacacagagt acacagtcct 31740 ttctccccgg ctggccttaa aaagcatcat atcatgggta acagacatat tcttaggtgt 31800 tatattccac acggtttcct gtcgagccaa acgctcatca gtgatattaa taaactcccc 31860 gggcagctca cttaagttca tgtcgctgtc cagctgctga gccacaggct gctgtccaac 31920 ttgcggttgc ttaacgggcg gcgaaggaga agtccacgcc tacatggggg tagagtcata 31980 atcgtgcatc aggatagggc ggtggtgctg cagcagcgcg cgaataaact gctgccgccg 32040 ccgctccgtc ctgcaggaat acaacatggc agtggtctcc tcagcgatga ttcgcaccgc 32100 ccgcagcata aggcgccttg tcctccgggc acagcagcgc accctgatct cacttaaatc 32160 agcacagtaa ctgcagcaca gcaccacaat attgttcaaa atcccacagt gcaaggcgct 32220 gtatccaaag ctcatggcgg ggaccacaga acccacgtgg ccatcatacc acaagcgcag 32280 gtagattaag tggcgacccc tcataaacac gctggacata aacattacct cttttggcat 32340 gttgtaattc accacctccc ggtaccatat aaacctctga ttaaacatgg cgccatccac 32400 caccatccta aaccagctgg ccaaaacctg cccgccggct atacactgca gggaaccggg 32460 actggaacaa tgacagtgga gagcccagga ctcgtaacca tggatcatca tgctcgtcat 32520 gatatcaatg ttggcacaac acaggcacac gtgcatacac ttcctcagga ttacaagctc 32580 ctcccgcgtt agaaccatat cccagggaac aacccattcc tgaatcagcg taaatcccac 32640 actgcaggga agacctcgca cgtaactcac gttgtgcatt gtcaaagtgt tacattcggg 32700 cagcagcgga tgatcctcca gtatggtagc gcgggtttct gtctcaaaag gaggtagacg 32760 atccctactg tacggagtgc gccgagacaa ccgagatcgt gttggtcgta gtgtcatgcc 32820 aaatggaacg ccggacgtag tcatatttcc tgaagcaaaa ccaggtgcgg gcgtgacaaa 32880 cagatctgcg tctccggtct cgccgcttag atcgctctgt gtagtagttg tagtatatcc 32940 actctctcaa agcatccagg cgccccctgg cttcgggttc tatgtaaact ccttcatgcg 33000 ccgctgccct gataacatcc accaccgcag aataagccac acccagccaa cctacacatt 33060 cgttctgcga gtcacacacg ggaggagcgg gaagagctgg aagaaccatg tttttttttt 33120 tattccaaaa gattatccaa aacctcaaaa tgaagatcta ttaagtgaac gcgctcccct 33180 ccggtggcgt ggtcaaactc tacagccaaa gaacagataa tggcatttgt aagatgttgc 33240 acaatggctt ccaaaaggca aacggccctc acgtccaagt ggacgtaaag gctaaaccct 33300 tcagggtgaa tctcctctat aaacattcca gcaccttcaa ccatgcccaa ataattctca 33360 tctcgccacc ttctcaatat atctctaagc aaatcccgaa tattaagtcc ggccattgta 33420 aaaatctgct ccagagcgcc ctccaccttc agcctcaagc agcgaatcat gattgcaaaa 33480 attcaggttc ctcacagacc tgtataagat tcaaaagcgg aacattaaca aaaataccgc 33540 gatcccgtag gtcccttcgc agggccagct gaacataatc gtgcaggtct gcacggacca 33600 gcgcggccac ttccccgcca ggaaccatga caaaagaacc cacactgatt atgacacgca 33660 tactcggagc tatgctaacc agcgtagccc cgatgtaagc ttgttgcatg ggcggcgata 33720 taaaatgcaa ggtgctgctc aaaaaatcag gcaaagcctc gcgcaaaaaa gaaagcacat 33780 cgtagtcatg ctcatgcaga taaaggcagg taagctccgg aaccaccaca gaaaaagaca 33840 ccatttttct ctcaaacatg tctgcgggtt tctgcataaa cacaaaataa aataacaaaa 33900 aaacatttaa acattagaag cctgtcttac aacaggaaaa acaaccctta taagcataag 33960 acggactacg gccatgccgg cgtgaccgta aaaaaactgg tcaccgtgat taaaaagcac 34020 caccgacagc tcctcggtca tgtccggagt cataatgtaa gactcggtaa acacatcagg 34080 ttgattcaca tcggtcagtg ctaaaaagcg accgaaatag cccgggggaa tacatacccg 34140 caggcgtaga gacaacatta cagcccccat aggaggtata acaaaattaa taggagagaa 34200 aaacacataa acacctgaaa aaccctcctg cctaggcaaa atagcaccct cccgctccag 34260 aacaacatac agcgcttcca cagcggcagc cataacagtc agccttacca gtaaaaaaga 34320 aaacctatta aaaaaacacc actcgacacg gcaccagctc aatcagtcac agtgtaaaaa 34380 agggccaagt gcagagcgag tatatatagg actaaaaaat gacgtaacgg ttaaagtcca 34440 caaaaaacac ccagaaaacc gcacgcgaac ctacgcccag aaacgaaagc caaaaaaccc 34500 acaacttcct caaatcgtca cttccgtttt cccacgttac gtcacttccc attttaagaa 34560 aactacaatt cccaacacat acaagttact ccgccctaaa acctacgtca cccgccccgt 34620 tcccacgccc cgcgccacgt cacaaactcc accccctcat tatcatattg gcttcaatcc 34680 aaaataaggt atattattga tgatgtaggg ataacagggt aat 34723 <210> 77 <211> 34858 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO201) <400> 77 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgcctt atgagtggaa gcgcttcttt tgagggggga gtatttagcc cttatctgac 3660 gggcaggctc ccaccatggg caggagttcg tcagaatgtc atgggatcca ctgtggatgg 3720 gagacccgtc cagcccgcca attcctcaac gctgacctat gccactttga gttcgtcacc 3780 attggatgca gctgcagccg ccgccgctac tgctgccgcc aacaccatcc ttggaatggg 3840 ctattatgga agcatcgttg ccaattccag ttcctctaat aacccttcaa ccctggctga 3900 ggacaagcta cttgttctct tggcgcagct cgaggcctta acccaacgct taggcgaact 3960 gtctaagcag gtggcccagt tgcgtgagca aactgagtct gctgttgcca cagcaaagtc 4020 taaataaaac ataaataaaa aaccagactc tgtttggatt tggatcaagc aaaatgaatg 4080 tttatttgat ttttcgcgcg cggtatgccc tggaccatcg gtctcgatca ttgagaacgc 4140 ggtggatctt ttccagtacc ctgtaaaggt gggattgaat gtttagatac atgggcatta 4200 gtccgtctcg ggggtggaga tagctccatt gaagagcctc ttgctccggg gtagtgttat 4260 aaatcaccca gtcatagcaa ggtcggagtg catggtgttg cacaatatct tttaggagca 4320 gactaattgc aacggggagg cccttagtgt aggtgtttac aaatctgttg agctgggacg 4380 ggtgcatccg gggtgaaatt atatgcattt tggactggat cttgaggttg gcaatgttgc 4440 cgcctagatc ccgtctcggg ttcatattgt gcaggaccac caagacagtg tatccggtgc 4500 acttgggaaa tttatcatgc agcttagagg gaaaagcatg aaaaaatttg gagacgcctt 4560 tgtgaccccc cagattctcc atgcactcat ccataatgat agcgatgggg ccgtgggcag 4620 cggcacgggc gaacacgttc cgggggtctg aaacatcata gttatgctcc tgagtcaggt 4680 catcataagc cattttaata aactttgggc ggagggtgcc agattggggg atgaaagttc 4740 cctctggccc gggagcatag tttccctcac atatttgcat ttcccaggct ttcagttcag 4800 agggggggat catgtccacc tgcggggcta taaaaaatac cgtttctgga gccggggtga 4860 ttaactggga cgagagcaaa ttcctaagca gctgagactt gccgcaccca gtgggaccgt 4920 aaatgacccc aattacgggt tgcagatggt agtttaggga acgacagctg ccgtcctccc 4980 ggagcagggg ggccacttcg ttcatcattt cccttacatg gatattttcc cgcaccaagt 5040 ccgttaggag gcgctctccc ccaagggata gaagctcctg gagcgaggag aagtttttca 5100 gcggcttcag cccgtcagcc atgggcattt tggaaagagt ctgttgcaag agctcgagcc 5160 ggtcccagag ctcggtgatg tgctctatgg catctcgatc cagcagacct cctcgtttcg 5220 cgggttggga cggctcctgg agtagggaat cagacgatgg gcgtccagcg ctgccagggt 5280 ccgatccttc catggtcgca gcgtccgagt cagggttgtt tccgtcacgg tgaaggggtg 5340 cgcgcctggt tgggcgcttg cgagggtgcg cttcagactc atcctgctgg tcgagaaccg 5400 ctgccgattg gcgccctgca tgtcggccag gtagcagttt accatgagtt cgtagttgag 5460 cgcctcggcc gcgtggcctt tggcacggag cttacctttg gaagttttat ggcaggcggg 5520 gcagtagata catttgaggg catacaactt gggcgcgagg aaaatggatt cgggggagta 5580 tgcatccgca ccgcaggagg cgcagacggt ttcgcactcc acgagccagg tcagatccgg 5640 ctcatcgggg tcaaaaacaa gttttccgcc atgttttttg atgcgtttct tacctttggt 5700 ttccatgagt tcgtgtcccc gctgggtgac aaagaggctg tccgtgtccc cgtagaccga 5760 ctttatgggc ctgtcctcga gcggagtgcc tcggtcctct tcgtagagga acccagccca 5820 ctctgataca aaagcgcgtg tccaggccag cacaaaggag gccacgtggg aggggtagcg 5880 gtcgttgtca accagggggt ccaccttctc tacggtatgt aaacacatgt ccccctcctc 5940 cacatccaag aatgtgattg gcttgtaagt gtaggccacg tgaccagggg tccccgccgg 6000 gggggtataa aagggggcgg gcctctgttc gtcctcactg tcttccggat cgctgtccag 6060 gagcgccagc tgttggggta ggtattccct ctcgaaggcg ggcatgacct ctgcactcag 6120 gttgtcagtt tctaggaacg aggaggattt gatattgaca gtaccagcag agatgccttt 6180 cataagactc tcgtccatct ggtcagaaaa cacaatcttc ttgttgtcca gcttggtggc 6240 aaatgatcca tagagggcat tggatagaag cttggcgatg gagcgcatgg tttggttctt 6300 ttccttgtcc gcgcgctcct tggcggtgat gttaagctgg acgtactcgc gcgccacaca 6360 tttccattca ggaaagatgg ttgtcagttc atccggaact attctgattc gccatcccct 6420 attgtgcagg gttatcagat ccacactggt ggccacctcg cctcggaggg gctcattggt 6480 ccagcagagt cgacctcctt ttcttgaaca gaaagggggg agggggtcta gcatgaactc 6540 atcagggggg tccgcatcta tggtaaatat tcccggtagc aaatctttgt caaaatagct 6600 gatggtggcg ggatcatcca aggtcatctg ccattctcga actgccagcg cgcgctcata 6660 ggggttaaga ggggtgcccc agggcatggg gtgggtgagc gcggaggcat acatgccaca 6720 gatatcgtag acatagaggg gctcttcgag gatgccgatg taagtgggat aacatcgccc 6780 ccctctgatg cttgctcgca catagtcata gagttcatgt gagggggcaa gaagacccgg 6840 gcccagattg gtgcggttgg gtttttccgc cctgtaaacg atctggcgaa agatggcatg 6900 ggaattggaa gagatagtag gtctctggaa tatgttaaaa tgggcatgag gtaagcctac 6960 agagtccctt atgaagtggg catatgactc ttgcagcttg gctaccagct cggcggtgat 7020 gagtacatcc agggcacagt agtcgagagt ttcctggatg atgtcataac gcggttggct 7080 tttcttttcc cacagctcgc ggttgagaag gtattcttcg tgatccttcc agtactcttc 7140 gaggggaaac ccgtcttttt ctgcacggta agagcccaac atgtagaact gattgactgc 7200 cttgtaggga cagcatccct tctccactgg gagagagtat gcttgggctg cattgcgcag 7260 cgaggtatga gtgagggcaa aagtgtccct gaccatgact ttgaggaatt gatacttgaa 7320 gtcgatgtca tcacaggccc cctgttccca gagttggaag tccacccgct tcttgtaggc 7380 ggggttgggc aaagcgaaag taacatcatt gaagaggatc ttgccggccc tgggcatgaa 7440 atttcgggtg attttgaaag gctgaggaac ctctgctcgg ttattgataa cctgagcggc 7500 caagacgatc tcatcaaagc cattgatgtt gtgccccact atgtacagtt ctaagaatcg 7560 aggggtgccc ctgacatgag gcagcttctt gagttcttca aaagtgagat ctgtagggtc 7620 agtgagagca tagtgttcga gggcccattc gtgcacgtga gggttcgctt taaggaagga 7680 ggaccagagg tccactgcca gtgctgtttg taactggtcc cggtactgac gaaaatgctg 7740 tccgactgcc atcttttctg gggtgacgca atagaaggtt tgggggtcct gccgccagcg 7800 atcccacttg agttttatgg cgaggtcata ggcgatgttg acgagccgct ggtctccaga 7860 gagtttcatg accagcatga aggggattag ctgcttgcca aaggacccca tccaggtgta 7920 ggtttccaca tcgtaggtga gaaagagcct ttctgtgcga ggatgagagc caatcgggaa 7980 gaactggatc tcctgccacc agttggagga atggctgttg atgtgatgga agtagaactc 8040 cctgcgacgc gccgagcatt catgcttgtg cttgtacaga cggccgcagt actcgcagcg 8100 attcacggga tgcaccttat gaatgagttg tacctgactt cctttgacga gaaatttcag 8160 tggaaaattg aggcctggcg cttgtacctc gcgctttact atgttgtctg catcggcatg 8220 accatcttct gtctcgatgg tggtcatgct gacgagccct cgcgggaggc aagtccagac 8280 ctcggcgcgg caggggcgga gctcgaggac gagagcgcgc aggccggagc tgtccagggt 8340 cctgagacgc tgcggagtca ggttagtagg cagtgtcagg agattaactt gcatgatctt 8400 ttggagggcg tgagggaggt tcagatagta cttgatctca acgggtccgt tggtggagat 8460 gtcgatggct tgcagggttc cgtgtccctt gggcgctacc accgtgccct tgtttttcat 8520 tttggacggc ggtggctctg ttgcttcttg catgtttaga agcggtgtcg agggcgcgca 8580 ccgggcggca ggggcggctc gggacccggc ggcatggctg gcagtggtac gtcggcgccg 8640 cgcgcgggta ggttctggta ctgcgccctg agaagactcg catgcgcgac gacgcggcgg 8700 ttgacatcct ggatctgacg cctctgggtg aaagctaccg gccccgtgag cttgaacctg 8760 aaagagagtt caacagaatc aatctcggta tcgttgacgg cggcttgcct aaggatttct 8820 tgcacgtcgc cagagttgtc ctggtaggcg atctcggcca tgaactgctc gatctcttcc 8880 tcttgaagat ctccgcggcc cgctctctcg acggtggccg cgaggtcgtt ggagatgcgc 8940 ccaatgagtt gagagaatgc attcatgccc gcctcgttcc agacgcggct gtagaccaca 9000 gcccccacgg gatctctcgc gcgcatgacc acctgggcga ggttgagctc cacgtggcgg 9060 gtgaagaccg catagttgca taggcgctgg aaaaggtagt tgagtgtggt ggcgatgtgc 9120 tcggtgacga agaaatacat gatccatcgt ctcagcggca tctcgctgac atcgcccagc 9180 gcttccaagc gctccatggc ctcgtagaag tccacggcaa agttaaaaaa ctgggagtta 9240 cgcgcggaca cggtcaactc ctcttccaga agacggataa gttcggcgat ggtggtgcgc 9300 acctcgcgct cgaaagcccc tgggatttct tcctcaatct cttcttcttc cactaacatc 9360 tcttcctctt caggtggggc tgcaggagga gggggaacgc ggcgacgccg gcggcgcacg 9420 ggcagacggt cgatgaatct ttcaatgacc tctccgcggc ggcggcgcat ggtctcggtg 9480 acggcacgac cgttctccct gggtctcaga gtgaagacgc ctccgcgcat ctccctgaag 9540 tggtgactgg gaggctctcc gttgggcagg gacaccgcgc tgattatgca ttttatcaat 9600 tgccccgtag gtactccgcg caaggacctg atcgtctcaa gatccacggg atctgaaaac 9660 ctttcgacga aagcgtctaa ccagtcgcaa tcgcaaggta ggctgagcac tgtttcttgc 9720 gggcgggggc ggctagacgc tcggtcgggg ttctctcttt cttctccttc ctcctcttgg 9780 gagggtgaga cgatgctgct ggtgatgaaa ttaaaatagg cagttttgag acggcggatg 9840 gtggcgagga gcaccaggtc tttgggtccg gcttgttgga tacgcaggcg atgagccatt 9900 ccccaagcat tatcctgaca tctggccaga tctttatagt agtcttgcat gagtcgttcc 9960 acgggcactt cttcttcgcc cgctctgcca tgcatgcgag tgatcccgaa cccgcgcatg 10020 ggctggacaa gtgccaggtc cgctacaacc ctttcggcga ggatggcttg ctgcacctgg 10080 gtgagggtgg cttggaagtc gtcaaagtcc acgaagcggt ggtaggcccc ggtgttgatt 10140 gtgtaggagc agttggccat gactgaccag ttgactgtct ggtgcccagg gcgcacgagc 10200 tcggtgtact tgaggcgcga gtatgcgcgg gtgtcaaaga tgtaatcgtt gcaggtgcgc 10260 accaggtact ggtagccaat gagaaagtgt ggcggtggct ggcggtacag gggccatcgc 10320 tctgtagccg gggctccggg ggcgaggtct tccagcatga ggcggtggta gccgtagatg 10380 tacctggaca tccaggtgat accggaggcg gtggtggatg cacgtgggaa ctcgcgcacg 10440 cggttccaga tgttgcgcag cggcatgaag tagttcatgg taggcacggt ctggccagtg 10500 aggcgcgcgc agtcattgac gctctgtaga cacggagaaa acgaaagcga tgagcggctc 10560 gactccgtgg tctgggggaa cgtgaacggg ttgggtcgcg gtgtaccccg gttcgagtcc 10620 aaagctaagc gatcacgctc ggatcggccg gagccgcggc taacgtggta ttggctatcc 10680 cgtctcgacc cagccgacga atatccaggg tacggagtag agtcgttttt gctgcttttt 10740 cctggacgtg tgccattgcc acgtcaagct ttagaacgct cagttctcgg gccgtgagtg 10800 gctcgcgccc gtagtctgga gaatcagtcg ccagggttgc gttgcggtat gccccggttg 10860 gagcctaagc gcggctcgta tcggccggtt tccgcgacaa gcgagggttt ggcagccccg 10920 ttatttccaa gaccccgcca gccgacttct ccagtttacg ggagcgagcc cttttttttt 10980 tttttttgtt tttgtcgccc agatgcatcc agtgctgcga cagatgcgcc cccagcaaca 11040 ggccccttct cagcaacagc cacaaaaggc tcttcttgct cctgcaacta ctgcagctgc 11100 agccgtgagc ggcgcgggac agcccgccta tgatctggac ttggaagagg gcgagggatt 11160 ggcgcgcctg ggggctccat cgcccgagcg gcacccgcgg gtgcaactaa aaaaggactc 11220 tcgcgaggcg tacgtgcccc agcagaacct gttcagggac aggagcggcg aggagccaga 11280 ggagatgcga gcatctcgat ttaacgcggg tcgcgagctg cgccacggtc tggatcgaag 11340 acgggtgctg caagacgagg attttgaggt cgatgaagtc acagggatca gcccagctag 11400 ggcacatgtg gccgcggcca acctagtctc ggcctacgag cagaccgtga aggaggagcg 11460 caacttccaa aaatctttta acaaccatgt gcgcaccctg atcgcccgcg aggaagtgac 11520 cctgggtctg atgcatctgt gggacctgat ggaggctatc gcccaaaacc ccactagcaa 11580 accactgaca gctcagctgt ttctggtggt tcaacatagc agggacaacg aggcattcag 11640 ggaggcgttg ttgaacatca ccgagcctga tgggagatgg ctgtatgatc tgatcaacat 11700 cctgcaaagt attatagtgc aggaacgtag cctgggtttg gctgagaaag tggcagctat 11760 caactactcg gtcttgagcc tgggcaaata ctacgctcgc aagatctaca agacccccta 11820 cgtacccata gacaaggagg tgaagataga tgggttttac atgcgcatga ctctgaaggt 11880 gctgactctg agcgacgatc tgggggtgta tcgcaatgac aggatgcacc gcgcggtgag 11940 cgccagcagg aggcgcgagc tgagcgacag agaacttatg cacagcttgc aaagagctct 12000 aacgggggcc gggactgatg gggagaacta ctttgacatg ggagcggatt tgcaatggca 12060 acccagtcgc agggccatgg aggctgcagg gtgtgagctt ccttacatag aagaggtgga 12120 tgaagtcgag gacgaggagg gcgagtactt ggaagactga tggcgcgacc cgtatttttg 12180 ctagatggaa cagcagcagg caccggaccc cgcaatgcgg gcggcgctgc agagccagcc 12240 gtccggcatt aactcctcgg acgattggac ccaggccatg caacgcataa tggcgctgac 12300 gacccgcaac cccgaagcct ttagacagca accccaggcc aaccgccttt ctgccatact 12360 ggaggccgta gtgccctccc gctccaaccc cacccacgag aaggtcctgg ctatcgtgaa 12420 cgcgctggtg gagaacaagg ccatccgtcc cgatgaggcc gggctggtat acaatgctct 12480 cttggagcgc gtggcccgtt acaacagcag caacgtgcaa accaacctgg accggatggt 12540 gaccgatgtg cgcgaggccg tgtctcagcg cgagcgattc cagcgcgacg ccaacttggg 12600 gtcgttggta gcgctaaacg ctttcctcag cacccagccc gccaacgtgc cccgtggtca 12660 gcaagactat acaaactttt tgagtgcatt gagactcatg gtagctgagg tgccccagag 12720 cgaggtgtac cagtccgggc cagattactt cttccagacc agcagacagg gcttgcagac 12780 agtgaacctg actcaggctt tcaagaacct gaagggtctg tggggagtgc acgccccagt 12840 aggggatcgc gcgaccgtgt ctagcttgct gactcccaac tcccgcctgc tgctgctgct 12900 ggtatccccc tttactgaca gcggtagcat tgaccgcaac tcgtacttgg gctacctgct 12960 taacctgtat cgcgaggcca taggacagag ccaggtggac gagcagacct atcaagaaat 13020 cacccaagtg agccgcgccc tgggtcagga agacacgggc agtttggaag ccaccctgaa 13080 cttcttgcta accaaccggt cacagaagat ccctcctcag tatgcgctta ccgctgagga 13140 ggagcggatc ctcagatacg tgcaacagag cgttggactg ttcctgatgc aggagggggc 13200 gacacctacc gccgcgctgg acatgacagc tcgaaacatg gagcccagca tgtatgctag 13260 taacaggcct ttcattaaca aactgctgga ctacctgcac agggcggccg ccatgaactc 13320 tgattatttc accaatgcta tcctgaaccc acactggctg cccccacctg gtttctacac 13380 tggcgagtac gacatgcccg accccaatga cgggttcctg tgggacgatg tggacagcag 13440 catattttcc ccgcctcccg gttatacagt ttggaagaag gaagggggcg atagaagaca 13500 ctcttccgtg tcgctatccg gaacggctgg tgctgccgcg accgtgcccg aagctgcaag 13560 tcctttccct agcttgccct tttcactaaa cagcgttcgc agcagtgaac tggggagaat 13620 aacccgcccg cgcttgatgg gcgaggatga gtacttgaat gactctttgc tgaggccaga 13680 gagggaaaag aacttcccca acaatggaat agagagtctg gtggataaga tgagtagatg 13740 gaagacctat gcgcaggatc acagagacga gcccaggatc ttgggggcta caagcagacc 13800 gatccgtaga cgccagcgcc acgacaggca gatgggtctt gtgtgggacg atgaggactc 13860 tgccgatgat agcagcgtgt tggacttggg tggaagagga gggggcaacc cgttcgctca 13920 tctgcgtccc agattcgggc gcatgttgta aaagtgaaag taaaataaaa aggcaactca 13980 ccaaggccat ggcgaccgag cgtgcgttcg ttcttttttg ttatctgtgt ctagtacgat 14040 gaggagacga gccgtgctag gcggagcggt ggtgtatccg gagggtcctc ctccttctta 14100 cgagagcgtg atgcagcaac aggcggcgat gatacagccc ccactggagg ctcccttcgt 14160 acccccacgg tacctggcgc ctacggaagg gagaaacagc attcgttact cggagctgtc 14220 gcccctgtac gataccacca agttgtatct ggtggacaac aagtcggcgg acatcgcctc 14280 cctgaactat cagaacgacc acagcaactt cctgaccacg gtggtgcaga acaatgactt 14340 tacccccacg gaggctagca cccagaccat caactttgac gagcggtcgc gatggggcgg 14400 tcagctgaag accatcatgc acaccaacat gcccaacgtg aacgagtaca tgttcagcaa 14460 caagttcaag gcgagggtga tggtgtccag aaaagctcct gaaggtgtta cagtaaatga 14520 cacctatgat cataaagagg atatcttgaa gtatgagtgg tttgagttca ttttaccaga 14580 aggcaacttt tcagccacca tgacgatcga cctgatgaac aatgccatca ttgacaacta 14640 cctggaaatt ggcagacaga atggagtgct ggaaagtgac attggtgtta agtttgacac 14700 tagaaatttc aggctcgggt gggaccccga aactaagttg attatgccag gtgtctacac 14760 ttatgaggca ttccatcctg acattgtatt gctgcctggt tgcggggtag actttactga 14820 aagccgactt agcaacttgc ttggcatcag gaagagacat ccattccagg agggtttcaa 14880 aatcatgtat gaagatcttg aagggggtaa tattcctgcc cttttggatg tcactgccta 14940 tgaggaaagc aaaaaggata ccactactga aacaaccaca ctggctgttg cagaggaaac 15000 tagtgaagat gatgatataa ctagaggaga tacctatata actgaaaaac aaaaacgtga 15060 agctgcagct gctgaagtta aaaaagagtt aaagatccaa cctctagaaa aagacagcaa 15120 gagtagaagc tacaatgtct tggaagacaa aatcaacaca gcctaccgca gttggtacct 15180 gtcctacaat tacggtaacc ctgagaaagg aataaggtct tggacactgc tcaccacttc 15240 agatgtcacc tgtggggcag agcaggtcta ctggtcgctc cctgacatga tgcaagaccc 15300 agtcaccttc cgctccacaa gacaagtcaa caactaccca gtggtgggtg cagagcttat 15360 gcccgtcttc tcaaagagtt tctacaatga gcaagccgtg tactctcagc agctccgaca 15420 ggccacttcg ctcacgcacg tcttcaaccg cttccctgag aaccagatcc tcatccgccc 15480 gccggcgccc acaattacca ccgtcagtga aaacgttcct gctctcacag atcacgggac 15540 cctgccgtta cgcagcagta tccggggagt ccagcgcgtg accgttactg acgccagacg 15600 ccgcacctgt ccctacgttt acaaggccct gggcatagtc gcgccgcgcg ttctttcaag 15660 ccgcactttc taaaaaaaaa aaaaatgtcc attctcatct cgcccagtaa taataccggt 15720 tggggactgt atgcgcccac caagatgtat ggaggcgccc gcaagcgctc tacccagcat 15780 cctgtgcgcg ttcgcggtca tttccgcgct ccctggggcg cactcaaggg tcgtacccgc 15840 actcggacca cggtcgatga tgtgatcgac caggtggtcg ccgatgctcg taattatact 15900 cctactgcgc ctacatctac tgtggatgca gttattgaca gtgtggtggc agacgcccgc 15960 gcctatgctc gccggaagag ccgaaggagg cgcatcgcca ggcgccacag ggctactccc 16020 gccatgcgag ccgcaaaagc tattctgcgg agggccaaac gtgtggggcg aagagccatg 16080 cttagagcgg ccagacgcgc ggcttcaggt gccagcagcg gcaggtcccg caggcgcgcg 16140 gccacggcgg cagcagcggc cattgccaac atggcccaac cgcgaagagg caatgtgtac 16200 tgggtgcgtg atgccactac cggccagcgc gtgcccgtgc gcacccgccc ccctcgcact 16260 tagaagatac tgagcagtct ccgatgttgt gtcccagcgg caagtatgtc caagcgcaaa 16320 tacaaggaag agatgctcca ggtcatcgcg cctgaaatct acggtccgcc ggtgaaggat 16380 gaaaaaaagc cccgcaaaat caagcgggtc aaaaataaca aaaaggaaga agatgacgat 16440 gatgggctgg tggagtttgt gcgcgagttc gccccaagac ggcgcgtgca gtggcgcggg 16500 cgcaaagtgc gtcaagtgct cagacccggg accactgtgg tttttacacc tggcgagcgt 16560 tccagcacta cttttaaacg gtcctatgat gaggtgtacg gggatgacga tattcttgag 16620 caggcggcag accgccttga cgagtttgct tatggcaagc gcactagatc cagtcccaaa 16680 gaggaggctg tgtccattcc tttggatcat ggaaatccca cccccagcct caaaccagtc 16740 accctgcagc aagtgctgcc cgtgcctgcg cggagaggcg taaagcgcga gggtgaggac 16800 ctatatccca ccatgcagct aatggtgccc aagcgccaga ggctagaaga cgtactggag 16860 aaaatgaaag tggatgccga tatccagcct gaggtcaaag taagacctat caaggaagtg 16920 gcgccaggtt tgggagtaca aaccttcgac atcaagattc ccaccgagtc catggaagtg 16980 cagaccgaac ctgcaaaacc caccacctca attgaggtgc aaacggaacc ctggatgccc 17040 gcgcccgttg ccgcccccag caccactcga agatcacgac gaaagtacgg cccagcaagt 17100 ctgctaatgc ccaactatgc tctgcaccca tccatcattc ccactccggg ttacagaggc 17160 actcgctact atcgaaaccg gagcaacacc tctcgccgcc gcaaaccacc tgcaagtcgc 17220 actcgccgtc gccgccgccg caacactgcc agcaaattga ctcccgccgc cctggtgcgg 17280 agagtgtacc gcgatggtcg cgctgaacct ctgacgctgc cgcgcgcgcg ctaccatcca 17340 agcatcacca cttaatgact gttgacgctg cctccttgca gatatggccc tcacttgccg 17400 ccttcgcgtc cccattactg gctaccgagg aagaaactcg cgccgtagaa ggatgttggg 17460 gcgagggatg cgccgccaca gacgaaggcg cgctatcagc agacgattag ggggtggctt 17520 tttgccagct cttataccca tcatcgccgc agcgatcggg gcgataccag gcatagcttc 17580 agtggcggtt caggcctcgc agcgccacta acattggaaa aaacttataa ataaaaaata 17640 gaatggactc tgacgctcct ggtcctgtga ctatgttttt gtagagatgg aagacatcaa 17700 tttttcatcc ctggctccgc gacacggcac gaggccgtac atgggcacct ggagcgacat 17760 cggcacgagc caactgaacg ggggcgcctt caattggagc agtatctgga gcgggcttaa 17820 aaattttggc tcgaccgtaa aaacctatgg gaacaaagct tggaacagca gcacagggca 17880 ggctctgaga aataagctta aggaacaaaa cttccaacag aaggtggtcg atgggatcgc 17940 ctctggtatt aacggcgtag tggatctggc caaccaggct gtacaaaaac agataaacag 18000 ccgcctggac ccgccgcccg caacccctgg tgaaatggaa gtggaggaag aacttcctcc 18060 gctggaaaag cggggcgaca agcgtccgcg acccgagcta gagcagacgc tggtgacgcg 18120 cgcagacgag cccccttcat atgaggaggc agtaaagctc ggaatgccca ctaccaggcc 18180 tgtagctcac atggctaccg gggtgatgaa accttctcag tcacatcgac ccgccacctt 18240 ggacttgcct cctccccctg cttctgcggc gcctgttccc aaacctgtcg ctaccagaaa 18300 gcccaccgcc gtacagcccg tcgccgtagc cagaccgcgt cctgggggca caccgcgccc 18360 gaaagcaaac tggcaaagta ctctgaacag catcgtgggt ctgggcgtgc agagtgtaaa 18420 gcgccgtcgc tgctattaat taaatatgga gtagcgctta acttgcttgt ctgtgtgtat 18480 gtatcatcac cacgccgccg cagcagagga gaaaggaaga ggtcgcgcgc cgaggctgag 18540 ttgctttcaa gatggccacc ccatcgatga tgccccaatg ggcatacatg cacatcgccg 18600 gacaggatgc ttcggagtac ctcagtccgg gtctggtgca gttcgcccgt gcaacagaca 18660 cctacttcag tatggggaac aaatttagaa accccacagt ggcgcccacc cacgatgtga 18720 ccaccgaccg tagccagcgc ctgatgctgc gcttcgtgcc cgttgaccgg gaagacaata 18780 cctactctta caaagttcgc tacacgctgg ctgtaggcga caacagagtg cttgacatgg 18840 ccagcacatt ctttgacatt cggggggtgc ttgatagagg tcctagcttc aagccatatt 18900 ccggcacagc ttacaattca ctcgctccta agggcgcgcc caatacatct cagtggatag 18960 ttacaacaaa tggggacaat gcagtaacta ccaccacaaa cacatttggc attgcttcca 19020 tgaagggaga caatattact aaagaaggtt tgcaaattgg gaaagacatt accactactg 19080 aaggagaaga aaagcccatt tatgccgata aaacatatca gccagagcct caagttggag 19140 aagaatcatg gactgatact gatggaacaa atgaaaagtt tggtggaaga gcccttaaac 19200 cagctaccaa catgaagcca tgctacgggt cttttgcaag acctacaaac ataaaagggg 19260 gccaagctaa aaacagaaaa gtaaaaccaa caaccgaagg aggggttgaa actgaggaac 19320 cagatattga tatggaattt ttcgatggta gagatgctgt tgcaggagct ttagcgcctg 19380 aaattgtgct ttatacggaa aatgtaaatt tggaaactcc agacagtcat gtggtatata 19440 aaccagaaac gtctaataac tctcatgcaa atttgggtca acaagccatg cctaacagac 19500 ccaattacat tggcttcagg gataacttcg taggcctaat gtactacaac agtactggaa 19560 atatgggagt tttggctggc caagcatcac aactgaatgc agtggttgac ttgcaggaca 19620 gaaatactga actgtcatat cagcttttgc ttgattctct gggagacaga accagatact 19680 tcagcatgtg gaatcaggct gtggacagtt acgatcccga tgttcgcatt attgaaaatc 19740 atggcatcga ggatgaactg cctaattact gttttcctct gaatggcata ggaccagggc 19800 acacatatca aggcattaaa gttaaaaccg atgacactaa tggatgggaa aaagatgcta 19860 atgttgctcc agctaatgaa ataaccatag gcaacaacct ggctatggaa attaatatcc 19920 aagctaacct ttggagaagt tttctgtact ctaatgtggc tttgtacctt ccagatgttt 19980 acaagtacac gccacctaac attactttgc ccactaacac caacacctat gagtacatga 20040 acgggcgagt ggtatcccca tccctggttg attcatacat caacattggc gccaggtggt 20100 ctcttgaccc aatggacaat gtgaatccat tcaaccacca ccgcaatgct ggtctgcgct 20160 acaggtccat gcttctggga aatggtcgtt atgtgccttt ccacatacaa gtgcctcaga 20220 aattctttgc tgtcaagaac ctacttcttc tacctggctc ctacacctac gagtggaact 20280 tccgaaagga tgtgaacatg gtcctgcaaa gttcccttgg aaatgacctc agaacggatg 20340 gtgctaccat aagtttcacc agcatcaatc tctatgccac cttcttcccc atggctcaca 20400 acacagcttc cacccttgaa gccatgctgc gcaacgatac caatgatcag tcatttaacg 20460 actacctctc tgcagctaac atgctttacc ccattcctgc caatgcaacc aacattccaa 20520 tttccatccc atctcgcaac tgggcagcct tcaggggctg gtccttcacc agactcaaaa 20580 ccaaggagac tccatctctt ggatcagggt tcgatcccta cttcgtatat tctggatcta 20640 ttccctacct ggatggcacc ttttacctta accacacttt caagaaggtc tccatcatgt 20700 ttgactcctc agtcagctgg cctggcaatg acaggctgtt gagtccaaat gagtttgaaa 20760 tcaagcgcac tgtggacggg gaaggataca acgtggcaca atgcaacatg accaaagact 20820 ggttcctggt tcagatgctt gccaattaca acattggcta ccagggcttt tacatccctg 20880 agggatacaa ggatcgcatg tactcctttt tcagaaactt ccagcctatg agcaggcagg 20940 tggttgatga ggttaattac actgactaca aagccgtcac cttaccatac caacacaaca 21000 actctggctt tgtagggtac cttgcaccta ctatgagaca aggggaacct tacccagcca 21060 attatccata cccgctcatc ggaactactg ccgttaagag tgtcacccag aaaaagttcc 21120 tgtgcgacag gaccatgtgg cgcattccct tctccagcaa cttcatgtcc atgggggccc 21180 ttaccgacct gggacagaac atgctctatg ccaactcagc ccatgcgctg gacatgactt 21240 ttgaggtgga tcccatggat gagcccaccc tgctttatct tcttttcgaa gtcttcgacg 21300 tggtcagagt gcaccagcca caccgcggcg tcatcgaggc cgtctacctg cgcacaccgt 21360 tctcggccgg caacgccacc acataagaag cctcttgctt cttgcaagca gcagctgcag 21420 ccatgacatg cgggtccgga aacggctcca gcgagcaaga gctcaaagcc atcgtccgag 21480 acctgggctg cggaccctat ttcctgggaa cctttgacaa gcgtttcccg gggttcatgg 21540 cccccgacaa gctcgcctgc gccatagtca acactgccgg acgcgagacg gggggagagc 21600 actggctggc ttttggttgg aacccgcgct acaacacctg ctaccttttt gatccttttg 21660 ggttctcgga tgagcggctc aaacagattt accagtttga gtacgagggg ctcctgcgtc 21720 gcagtgccct tgctaccaaa gaccgctgca tcaccctgga gaagtctacc caaagcgtgc 21780 agggtccgcg ctcagccgcc tgtggacttt tttgctgtat gttccttcat gcctttgtgc 21840 actggcccga ccgccccatg gacggaaacc ccaccatgaa gttgctgact ggggtgtcca 21900 acagcatgct ccaatcaccc caagtccagc ccaccctgcg ccgcaaccag gaggtgctat 21960 accgcttcct aaacacccac tcatcttact ttcgttctca ccgcgcgcgc attgaaaggg 22020 ccaccgcgtt tgaccgtatg gatatgcaat aagtcatgta aaaccgtgtt caataaacag 22080 cactttattt ttacatgcac tgaggctctg gttttgctca tttgtttcat catttactca 22140 gaagtcgaat gggttctggc gggagtcaga gtgacccgcg ggcagggata cgttgcggaa 22200 ctgtaacctg ttctgccact tgaactcggg gattaccagc ttgggaactg gaatctcggg 22260 aaaggtgtct tgccacaact ttctggtcag ttgcatagcg ccaagcaggt caggagcaga 22320 gatcttgaaa tcacagttgg ggccggcatt ctggacacgg gagttgcgat acactgggtt 22380 gcaacactgg aacactatca acgctgggtg tcttacgctt gccaacacgg ttgggtcact 22440 gatggtagtc acatccaagt cttcagcatt ggccatccca aagggggtca tcttacatgt 22500 ctgcctgccc atcacgggag cgcagcctgg cttgtggttg caatcacaat gaatggggat 22560 cagcatcatc ctggcttggt cgggagttat ccctgggtac acagccttca tgaaggcttc 22620 gtactgctta aaagcttcct gggccttact tccctcggtg tagaacatcc cacaggactt 22680 gctggaaaat tgattagtag tacagttggc atcattcaca caacagcggg catcgttgtt 22740 ggccaactga accacatttc tgccccagcg gttttgggtg atcttggctc tgtctggatt 22800 ctccttcata gcgcgctgcc cgttctcgct cgccacatcc atctcgataa tgtggtcctt 22860 ctggatcatg atagtgccat gcaggcattt caccttgcct tcataatcgg tgcatccatg 22920 agcccacaga gcgcacccgg tgcactccca attattgtgg gcgatctcag aataataatg 22980 taccaatccc tgcatgaatc ttcccatcat tgttgtcaag gtcttcatgc tggtaaatgt 23040 cagcgggatg ccacggtgct cctcgttcac atactggtgg cagatacgct tgtattgctc 23100 gtgctgctct ggcatcagct tgaaagaggt tctcagatca ttatccagcc tgtacctttc 23160 cattagcaca gccatcactt ccatgccctt ctcccaggca gataccaggg gcagactcaa 23220 aggattccta acagcaataa aagtagctcc tttagctata gggtcattct tgtcgatctt 23280 ctcaacactt ctcttgccat ccttctcaat gatgcgcacc ggggggtagc tgaagcccac 23340 ggccaccaac tgagcctgtt ctctttcttc ttcactatcc tggctgatgt cttgcagagg 23400 gacatgcttg gtcttcctgg gcttcttctt gggagggatc gggggaggac tgttgctccg 23460 ctccggagac agggatgact gcgaagtttc gcttaccaat accacctggc tctcggtaga 23520 agaaccggac cccacacgac ggtaggtgtt cctcttcggg ggcagaggtg gaggcgactg 23580 agatgggctg cggtctggcc ttggaggcgg atggctggca gagctcattc cgcgttcggg 23640 ggtgtgctcc cggtggcggt cgcttgactg atttcctccg cggctggcca ttgtgttctc 23700 ctaggcagag aaacaacaga catggaaact cagccatcac tgccaacatc gctgcaagca 23760 ccatcacacc tcgcccccag cagcgacgag gaggagagct taaccacccc accacccagt 23820 cccgctacca ccacctctac cctcgatgat gaggaggagg tcgacgcagc ccaggagatg 23880 caggcgcagg ataatgtgaa aacggaagag attgaggcag atgtcgagca ggacccgggc 23940 tatgtgacgc cggcggagca ccaggaggag ctgaaacgct ttctagacag agaggatgac 24000 gaccgcccag agcatcaagc agatggcgtt taccaggagg ctgggatcag ggatcatgtc 24060 gccgactacc tcaccggcct tggtggggag gacgtgctcc tcaaacatct agcaaggcag 24120 tcgatcatag ttaaagacgc attgctcgat ctcactgaag tgcccatcag tgtggaagag 24180 cttagccgcg cctacgagct gaacctcttt tcgcctcagg taccccccaa gcggcagcca 24240 aacggcacct gcgaggccaa ccctcgactc aacttctatc cagcttttac tatccccgaa 24300 gtgttggcca cctaccacat ctttttcaag aaccaaaaga ttccagtctc ctgccgcgcc 24360 aaccgcaccc gcgccgatgc cctgctcaac ttgggtccgg gagctcgctt acctgatata 24420 gcttccttgg aagaggttcc aaagatcttt gagggtctgg gaagtgatga gacacgggcc 24480 gcaaatgctc tgcaacaggg agagaatgac atggatgaac accacagcgc tctggtggaa 24540 ctggagggtg acaatgcccg gattgcagtg ctcaagcgca gtatcgtggt cacccatttt 24600 gcctaccccg ctgttaacct gccccccaaa gttatgagcg ctgtcatgga ccatctgctc 24660 atcaaacgag caagacctct ttcagaaaac cagaacatgc aggatccaga cgcctcggac 24720 gagggcaagc cggtagtcag tgacgagcag ctatctcgct ggctgggtac caactccccc 24780 cgagatttgg aagagaggcg caagcttatg atggctgtag tgctagtaac tgtggagctg 24840 gagtgtctgc gccgcttttt caccgaccct gagaccctgc gcaagctaga ggagaacctg 24900 cactacacct ttagacatgg cttcgtgcgg caggcatgca agatctccaa cgtggagctt 24960 accaacctgg tttcttacat gggcattttg catgagaacc gactagggca gagcgtcctg 25020 cacaccaccc ttaaagggga ggcccgccgt gactacatcc gagactgtgt ctacctctac 25080 ctctgccata cctggcaaac tggtatgggt gtgtggcaac agtgtttgga agagcagaac 25140 ctaaaagagc tggacaagct cttgcagaga tccctcaaag ccctgtggac aggttttgat 25200 gagcgcaccg tcgcctcgga cctggcagac atcatcttcc ccgagcgtct cagggttact 25260 ctgcgaaacg gcctgccaga ctttatgagc cagagcatgc ttaacaactt tcgctctttc 25320 atcctggaac gctccggtat cctgcctgcc acctgctgtg cgctgccctc cgactttgtg 25380 cctctcacct accgcgagtg cccaccgccg ctatggagcc actgctacct gttccgcctg 25440 gccaactacc tctcctacca ctcggatgtt atagaggatg tgagcggaga cggcctgctg 25500 gaatgccact gccgctgcaa tctttgcaca ccccaccgct cccttgcctg caacccccag 25560 ttgctgagcg agacccagat tatcggcacc ttcgagctgc agggtcccag aagtaaaggc 25620 gaggggtctt ctccggggca gagtttgaaa ctgacaccgg ggctgtggac ctccgcctac 25680 ctgcgcaagt ttcaccccga ggactaccat ccctatgaga tcaggttcta tgaggaccaa 25740 tcacatcctc ccaaagtcga gctctcagcc tgcgtcatca cccagggagc aattctggcc 25800 caattgcaag ccatccaaaa atctcgccaa gaatttctgc taaaaaaggg aaacggggtc 25860 taccttgacc ctcagaccgg tgaggagctc aacacaaggt tcccccagga tgtcccatcg 25920 ccgaggaagc aagaagttga aggtgcagct gtcgccccca gaggatatga aggaagactg 25980 ggacagtcag gcagaggagg agatggaaga ttgggacagc caggcagagg aggtggacag 26040 cctggaggaa gacagtttgg aggaggaaga cgaggaggca gaggaggtgg aagaagcaac 26100 cgccgccaaa cagttgtcat cggcggcgga gacaagcaag tccccagaca gcagcacggc 26160 taccatctcc gctccgggtc ggggggccca gcggcggccc aacagtagat gggacgagac 26220 cgggcgattc ccaaacccga ccaccgcttc caagaccggt aagaaggagc gacagggata 26280 caagtcctgg cgtggacata aaaacgctat catctcctgc ttgcatgaat gcgggggcaa 26340 catatccttc acccggcgat acctgctctt ccaccacggt gtaaacttcc cccgcaatat 26400 cttgcattac taccgtcacc tccacagccc ctactgcagt cagcaagtcc cggcaacccc 26460 gacagaaaaa tacagcagcg acaacggtga ccagaaaacc agcagttaga aaatccacaa 26520 caagtgcacc aggaggagga ctgaggatca cagcgaacga gccagcgcag accagagagc 26580 tgaggaaccg gatctttcca accctctatg ccattttcca gcagagtcgg gggcaagagc 26640 aggaactgaa agtaaaaaac cgatctctgc gctcgctcac cagaagttgt ttgtatcaca 26700 agagcgaaga ccaacttcag cgcactctcg aggacgccga ggctctcttc aacaagtact 26760 gcgcgctgac tcttaaagag tagcccttgc ccgcgctcat tttgaaaacg gcgggaatca 26820 cgtcaccctt ggcacctgtc ctttgccctt gtcatgagta aagagattcc cacgccttac 26880 atgtggagct atcagcccca aatggggttg gcagcaggcg cttcccagga ctactccacc 26940 cgcatgaatt ggcttagcgc cgggccctca atgatatcac gggttaatga tatacgagct 27000 tatcgaaacc agttactcct agaacagtca gctctcacca ccacaccccg tcaacacctt 27060 aatccccgaa attggcccgc caccctggtg taccaggaaa atcccgctcc caccaccgta 27120 ctacttcctc gagacgccca ggccgaagtt cagatgacta acgcaggtgt acagctggcg 27180 ggcggttccg ccctatgtcg tcaccgacct caacagagta taaaacgcct ggtgattaga 27240 ggccgaggta tccagctcaa cgacgagtcg gttagctctt cgcttggtct gcgaccagac 27300 ggagtcttcc aaatcgccgg ctgtgggaga tcttccttca ctcctcgtca ggctgtgctg 27360 actttggaga gttcgtcctc gcagccccgc tcgggcggca ttggaactct ccagtttgtg 27420 gaggagttta ctccctctgt ctacttcaac cccttctccg gctctcctgg ccagtacccg 27480 gacgagttca taccaaactt cgacgcaatc agcgagtcag tggatggcta tgattgagtt 27540 tatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact gtcgccgcca 27600 caagtgcttt gcccgcgact ccggtgagtt ttgctacttt gaattgcccg aggatcatat 27660 cgagggcccg gcgcacggcg tccggcttac cgcccaggga gagcttgccc gtagcctgat 27720 tcgggagttt acccagcgcc ccctgctagt tgagcgggac aggggaccct gtgttctcac 27780 tgtgatttgc aactgtccta accctggatt acatcaagat ctttgttgcc atctctgtgc 27840 tgagtataat aaatacagaa attaaaatat actggggctc ctatcgccat cctgtaaacg 27900 ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt acctggtact tttaacatct 27960 ctccctctgt gatttacaac agtttcaacc cagacggagt gagtctacga gagaacctct 28020 ccgagctcag ctactccatc agaaaaaaca ccaccctcct tacctgccgg gaacgtacga 28080 gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg taaaccagac tttttccgga 28140 cagacctcaa taactctgtt taccagaaca ggaggtgagc ttagaaaacc cttagggtat 28200 taggccaaag gcgcagctac tgtggggttt atgaacaatt caagcaactc tacgggctat 28260 tctaattcag gtttctctag aatcggggtt ggggttattc tctgtcttgt gattctcttt 28320 attcttatac taacgcttct ctgcctaagg ctcgccgcct gctgtgtgca catttgcatt 28380 tattgtcagc tttttaaacg ctggggtcgc cacccaagat gattaggtac ataatcctag 28440 gtttactcac ccttgcgtca gcccacggta ccacccaaaa ggtggatttt aaggagccag 28500 cctgtaatgt tacattcgca gctgaagcta atgagtgcac cactcttata aaatgcacca 28560 cagaacatga aaagctgctt attcgccaca aaaacaaaat tggcaagtat gctgtttatg 28620 ctatttggca gccaggtgac actacagagt ataatgttac agttttccag ggtaaaagtc 28680 ataaaacttt tatgtatact tttccatttt atgaaatgtg cgacattacc atgtacatga 28740 gcaaacagta taagttgtgg cccccacaaa attgtgtgga aaacactggc actttctgct 28800 gcactgctat gctaattaca gtgctcgctt tggtctgtac cctactctat attaaataca 28860 aaagcagacg cagctttatt gaggaaaaga aaatgcctta atttactaag ttacaaagct 28920 aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca aattcaaaaa gttagcatta 28980 taattagaat aggatttaaa ccccccggtc atttcctgct caataccatt cccctgaaca 29040 attgactcta tgtgggatat gctccagcgc tacaaccttg aagtcaggct tcctggatgt 29100 cagcatctga ctttggccag cacctgtccc gcggatttgt tccagtccaa ctacagcgac 29160 ccaccctaac agagatgacc aacacaacca acgcggccgc cgctaccgga cttacatcta 29220 ccacaaatac accccaagtt tctgcctttg tcaataactg ggataacttg ggcatgtggt 29280 ggttctccat agcgcttatg tttgtatgcc ttattattat gtggctcatc tgctgcctaa 29340 agcgcaaacg cgcccgacca cccatctata gtcccatcat tgtgctacac ccaaacaatg 29400 atggaatcca tagattggac ggactgaaac acatgttctt ttctcttaca gtatgattaa 29460 atgagacatg attcctcgag tttttatatt actgaccctt gttgcgcttt tttgtgcgtg 29520 ctccacattg gctgcggttt ctcacatcga agtagactgc attccagcct tcacagtcta 29580 tttgctttac ggatttgtca ccctcacgct catctgcagc ctcatcactg tggtcatcgc 29640 ctttatccag tgcattgact gggtctgtgt gcgctttgca tatctcagac accatcccca 29700 gtacagggac aggactatag ctgagcttct tagaattctt taattatgaa atttactgtg 29760 acttttctgc tgattatttg caccctatct gcgttttgtt ccccgacctc caagcctcaa 29820 agacatatat catgcagatt cactcgtata tggaatattc caagttgcta caatgaaaaa 29880 agcgatcttt ccgaagcctg gttatatgca atcatctctg ttatggtgtt ctgcagtacc 29940 atcttagccc tagctatata tccctacctt gacattggct ggaacgcaat agatgccatg 30000 aaccacccaa ctttccccgc gcccgctatg cttccactgc aacaagttgt tgccggcggc 30060 tttgtcccag ccaatcagcc tcgcccacct tctcccaccc ccactgaaat cagctacttt 30120 aatctaacag gaggagatga ctgacaccct agatctagaa atggacggaa ttattacaga 30180 gcagcgcctg ctagaaagac gcagggcagc ggccgagcaa cagcgcatga atcaagagct 30240 ccaagacatg gttaacttgc accagtgcaa aaggggtatc ttttgtctgg taaagcaggc 30300 caaagtcacc tacgacagta ataccaccgg acaccgcctt agctacaagt tgccaaccaa 30360 gcgtcagaaa ttggtggtca tggtgggaga aaagcccatt accataactc agcactcggt 30420 agaaaccgaa ggctgcattc actcaccttg tcaaggacct gaggatctct gcacccttat 30480 taagaccctg tgcggtctca aagatcttat tccctttaac taataaaaaa aaataataaa 30540 gcttagacac ttacttgaaa tcagcaatac agtctttgtc aaaactttct accagcagca 30600 cctcaccctc ttcccaactc tggtactcta aacgtcggag ggtggcatac tttctccaca 30660 ctttgaaagg gatgtcaaat tttatttcct cttctttgcc cacaatcttc atttctttat 30720 ccccagatgg ccaagcgagc tcggctaagc acttccttca acccggtgta cccttatgaa 30780 gatgaaagca gctcacaaca cccatttata aatcctggtt tcatttcccc tgacgggttc 30840 acacaaagtc caaacggggt tttaagtctt aaatgtgtta atccacttac cactgcaagc 30900 ggctccctcc aacttaaagt gggaagtggt cttacagtag acactactga tggatcctta 30960 gaagaaaaca tcaaagttaa caccccccta acaaagtcaa accattctat aaatttacca 31020 ataggaaacg gtttgcaaat agaacaaaac aaactttgca gtaaactcgg aaatggtctt 31080 acatttgact cttccaattc tattgcactg aaaaataaca ctttatggac aggtccaaaa 31140 ccagaagcca actgcataat tgaatacggg aaacaaaacc cagatagcaa actaacttta 31200 atccttgtaa aaaatggagg aattgttaat ggatatgtaa cgctaatggg agcctcagac 31260 tacgttaaca ccttatttaa aaacaaaaat gtctccatta atgtagaact atactttgat 31320 gccactggtc atatattacc agactcatct tctcttaaaa cagatctaga actaaaatac 31380 aagcaaaccg ctgactttag tgcaagaggt tttatgccaa gtactacagc gtatccattt 31440 gtccttccta atgcgggaac acataatgaa aattatattt ttggtcaatg ctactacaaa 31500 gcaagcgatg gtgccctttt tccgttggaa gttactgtta tgcttaataa acgcctgcca 31560 gatagtcgca catcctatgt tatgactttt ttatggtcct tgaatgctgg tctagctcca 31620 gaaactactc aggcaaccct cataacctcc ccatttacct tttcctatat tagagaagat 31680 gactaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat tgcagaaaat 31740 ttcgaatcat ttttcattca gtagtatagc cccaccacca catagcttat acagatcacc 31800 gtaccttaat caaactcaca gaaccctagt attcaacctg ccacctccct cccaacacac 31860 agagtacaca gtcctttctc cccggctggc cttaaaaagc atcatatcat gggtaacaga 31920 catattctta ggtgttatat tccacacggt ttcctgtcga gccaaacgct catcagtgat 31980 attaataaac tccccgggca gctcacttaa gttcatgtcg ctgtccagct gctgagccac 32040 aggctgctgt ccaacttgcg gttgcttaac gggcggcgaa ggagaagtcc acgcctacat 32100 gggggtagag tcataatcgt gcatcaggat agggcggtgg tgctgcagca gcgcgcgaat 32160 aaactgctgc cgccgccgct ccgtcctgca ggaatacaac atggcagtgg tctcctcagc 32220 gatgattcgc accgcccgca gcataaggcg ccttgtcctc cgggcacagc agcgcaccct 32280 gatctcactt aaatcagcac agtaactgca gcacagcacc acaatattgt tcaaaatccc 32340 acagtgcaag gcgctgtatc caaagctcat ggcggggacc acagaaccca cgtggccatc 32400 ataccacaag cgcaggtaga ttaagtggcg acccctcata aacacgctgg acataaacat 32460 tacctctttt ggcatgttgt aattcaccac ctcccggtac catataaacc tctgattaaa 32520 catggcgcca tccaccacca tcctaaacca gctggccaaa acctgcccgc cggctataca 32580 ctgcagggaa ccgggactgg aacaatgaca gtggagagcc caggactcgt aaccatggat 32640 catcatgctc gtcatgatat caatgttggc acaacacagg cacacgtgca tacacttcct 32700 caggattaca agctcctccc gcgttagaac catatcccag ggaacaaccc attcctgaat 32760 cagcgtaaat cccacactgc agggaagacc tcgcacgtaa ctcacgttgt gcattgtcaa 32820 agtgttacat tcgggcagca gcggatgatc ctccagtatg gtagcgcggg tttctgtctc 32880 aaaaggaggt agacgatccc tactgtacgg agtgcgccga gacaaccgag atcgtgttgg 32940 tcgtagtgtc atgccaaatg gaacgccgga cgtagtcata tttcctgaag caaaaccagg 33000 tgcgggcgtg acaaacagat ctgcgtctcc ggtctcgccg cttagatcgc tctgtgtagt 33060 agttgtagta tatccactct ctcaaagcat ccaggcgccc cctggcttcg ggttctatgt 33120 aaactccttc atgcgccgct gccctgataa catccaccac cgcagaataa gccacaccca 33180 gccaacctac acattcgttc tgcgagtcac acacgggagg agcgggaaga gctggaagaa 33240 ccatgttttt ttttttattc caaaagatta tccaaaacct caaaatgaag atctattaag 33300 tgaacgcgct cccctccggt ggcgtggtca aactctacag ccaaagaaca gataatggca 33360 tttgtaagat gttgcacaat ggcttccaaa aggcaaacgg ccctcacgtc caagtggacg 33420 taaaggctaa acccttcagg gtgaatctcc tctataaaca ttccagcacc ttcaaccatg 33480 cccaaataat tctcatctcg ccaccttctc aatatatctc taagcaaatc ccgaatatta 33540 agtccggcca ttgtaaaaat ctgctccaga gcgccctcca ccttcagcct caagcagcga 33600 atcatgattg caaaaattca ggttcctcac agacctgtat aagattcaaa agcggaacat 33660 taacaaaaat accgcgatcc cgtaggtccc ttcgcagggc cagctgaaca taatcgtgca 33720 ggtctgcacg gaccagcgcg gccacttccc cgccaggaac catgacaaaa gaacccacac 33780 tgattatgac acgcatactc ggagctatgc taaccagcgt agccccgatg taagcttgtt 33840 gcatgggcgg cgatataaaa tgcaaggtgc tgctcaaaaa atcaggcaaa gcctcgcgca 33900 aaaaagaaag cacatcgtag tcatgctcat gcagataaag gcaggtaagc tccggaacca 33960 ccacagaaaa agacaccatt tttctctcaa acatgtctgc gggtttctgc ataaacacaa 34020 aataaaataa caaaaaaaca tttaaacatt agaagcctgt cttacaacag gaaaaacaac 34080 ccttataagc ataagacgga ctacggccat gccggcgtga ccgtaaaaaa actggtcacc 34140 gtgattaaaa agcaccaccg acagctcctc ggtcatgtcc ggagtcataa tgtaagactc 34200 ggtaaacaca tcaggttgat tcacatcggt cagtgctaaa aagcgaccga aatagcccgg 34260 gggaatacat acccgcaggc gtagagacaa cattacagcc cccataggag gtataacaaa 34320 attaatagga gagaaaaaca cataaacacc tgaaaaaccc tcctgcctag gcaaaatagc 34380 accctcccgc tccagaacaa catacagcgc ttccacagcg gcagccataa cagtcagcct 34440 taccagtaaa aaagaaaacc tattaaaaaa acaccactcg acacggcacc agctcaatca 34500 gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat ataggactaa aaaatgacgt 34560 aacggttaaa gtccacaaaa aacacccaga aaaccgcacg cgaacctacg cccagaaacg 34620 aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc gttttcccac gttacgtcac 34680 ttcccatttt aagaaaacta caattcccaa cacatacaag ttactccgcc ctaaaaccta 34740 cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa actccacccc ctcattatca 34800 tattggcttc aatccaaaat aaggtatatt attgatgatg tagggataac agggtaat 34858 <210> 78 <211> 34643 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO202) <400> 78 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgcctt atgagtggaa acgcttcttt taagggggga gtcttcagcc cttatctgac 3660 agggcgtctc ccatcctggg caggagttcg tcagaatgtt atgggatcta ctgtggatgg 3720 aagacccgtc caacccgcca attcttcaac gctgacctat gctactttaa gttcttcacc 3780 tttggacgca gctgcagccg ccgccgccgc ctctgttgcc gctaacactg tgcttggaat 3840 gggttactat ggaagtatcg tggctaattc cacttcctct aataaccctt ctaccctgac 3900 tcaggacaag ttacttgtcc ttttggccca gctggaggct ttgacccaac gtctgggtga 3960 actttatcag caggtggccg agttgcgagt acaaactgag tctgctgtcg gcacggcaaa 4020 gtctaaataa aacataaata aaaaaccaga ctctgtttgg atttggatca agcaaaatca 4080 agtgttttta tttcattttt cgcgcacggt atgccctaga ccaccgatct cgatcattga 4140 gaacacggtg gattttttcc agaatcctat agaggtggga ttgaatgttt agatacatgg 4200 gcattaggcc atctttgggg tggagatagc tccattgaag ggattcatgc tccggggtag 4260 tgttgtaaat cacccagtca taacaaggtc gcagtgcatg gtgttgcaca atatctttta 4320 gaagtaggct gattgccaca gataagccct tggtgtaggt gtttacaaac cggttgagct 4380 gggaggggtg cattcggggt gaaattatgt gcattttgga ttggattttt aagttggcaa 4440 tattgccgcc aagatctcgt cttgggttca tgttatgaag gaccaccaag acggtgtatc 4500 cggtacattt aggaaattta tcgtgtagct tggatggaaa agcgtggaaa aatttggaga 4560 cacccttgtg tcctccgaga ttttccatgc actcatccat gataatagca atggggccgt 4620 gggcagcagc gcgggcaaac acgttccgtg ggtctgacac atcatagtta tgttcctgag 4680 ttaaatcatc ataagccatt ttaatgaatt tggggcggag agtacccgat tggggtatga 4740 atgttccttc gggccccgga gcatagttcc cctcacagat ttgcatttcc caagctttca 4800 gttccgatgg tggaatcatg tccacctggg gggctatgaa gaacaccgtt tctggggcgg 4860 gggtgattag ttgggatgat agcaagtttc tgagcaattg agatttgcca catccggtgg 4920 ggccataaat gattccgatt acaggttgca ggtggtagtt tagggaacgg caactgccgt 4980 cttctcgaag caagggggcc acctcgttca tcatttccct tacatgcata ttttcccgca 5040 ccaaatccat taggaggcgc tctcctccta gtgatagaag ttcttgtagt gaggaaaagt 5100 ttttcagcgg ttttagaccg tcagccatgg gcattttgga gagagtttgc tgcaaaagtt 5160 ctagtctgtt ccacagttca gtgatgtgtt ctatggcatc tcgatccagc agacctcctc 5220 gtttcgcggg tttggacggc tcctggagta gggtatgaga cgatgggcgt ccagcgctgc 5280 cagggttcgg tccttccagg gtctcagtgt tcgagtcagg gttgtttccg tcacagtgaa 5340 ggggtgtgcg cctgcttggg cgcttgccag ggtgcgcttc agactcattc tgctggtgga 5400 gaacttctgt cgcttggcgc cctgtatgtc ggccaagtag cagtttacca tgagttcgta 5460 gttgagcgcc tcggctgcgt ggcctttggc gcggagctta cctttggaag ttttcttgca 5520 taccgggcag tataggcatt tcagcgcata cagcttgggc gcaaggaaaa tggattctgg 5580 ggagtatgca tctgcgccgc aggaggcgca aacagtttca cattccacca gccaggttaa 5640 atccggttca ttggggtcaa aaacaagttt tccgccatat tttttgatgc gtttcttacc 5700 tttggtctcc atgagttcgt gtcctcgttg agtgacaaac aggctgtccg tatccccgta 5760 gactgatttt acaggcctct tctccagtgg agtgcctcgg tcttcttcgt acaggaactc 5820 tgaccactct gatacaaagg cgcgcgtcca ggccagcaca aaggaggcta tgtgggaggg 5880 gtagcgatcg ttgtcaacca gggggtccac cttttccaaa gtatgcaaac acatgtcacc 5940 ctcttcaaca tccaggaatg tgattggctt gtaggtgtat ttcacgtgac ctggggtccc 6000 cgctgggggg gtataaaagg gggcggttct ttgctcttcc tcactgtctt ccggatcgct 6060 gtccaggaac gtcagctgtt ggggtaggta ttccctctcg aaggcgggca tgacctctgc 6120 actcaggttg tcagtttcta agaacgagga ggatttgata ttgacagtgc cggttgagat 6180 gcctttcatg aggttttcgt ccatttggtc agaaaacaca atttttttat tgtcaagttt 6240 ggtggcaaat gatccataca gggcgttgga taaaagtttg gcaatggatc gcatggtttg 6300 gttcttttcc ttgtccgcgc gctctttggc agcgatgttg agttggacat actcgcgtgc 6360 taggcacttc cattcgggga agatagttgt caattcatct ggcacgattc tcacttgcca 6420 ccctcgatta tgcaaggtaa ttaaatccac actggtggcc acctcgcctc gaaggggttc 6480 gttggtccaa cagagcctac ctcctttcct agaacagaaa gggggaagtg ggtctagcat 6540 aagttcatcg ggagggtctg catccatggt aaagattccc ggaagtaaat ccttatcaaa 6600 atagctgatg ggagtggggt catctaaggc catttgccat tctcgagctg ccagtgcacg 6660 ctcatatggg ttaaggggac tgccccaggg catgggatgg gtgagtgcag aggcatacat 6720 gccacagatg tcatagacgt agatgggatc ctcaaagatg cctatatagg ttggatagca 6780 tcgcccccct ctgatacttg ctcgcacata gtcatatagt tcatgtgatg gcgctagcaa 6840 ccccggaccc aagttggtgc gattgggttt ttctgttctg tagacaatct ggcgaaagat 6900 ggcgtgagaa ttggaagaga tggtgggtct ttgaaaaatg ttgaaatggg catgaggtag 6960 acctacagag tctctgacaa agtgggcata agattcttga agcttggtta ccagttcggc 7020 ggtgacaagt acgtctaggg cgcagtagtc aagtgtttct tgaatgatgt cataacctgg 7080 ttggtttttc ttttcccaca gttcgcggtt gagaaggtat tcttcgcgat ccttccagta 7140 ctcttctagc ggaaacccgt ctttgtctgc acggtaagat cctagcatgt agaactgatt 7200 aactgccttg taagggcagc agcccttctc tacgggtaga gagtatgctt gagcagcttt 7260 tcgcagcgaa gcgtgagtaa gggcgaaggt gtctctgacc atgactttga gaaattggta 7320 tttgaagtcc atgtcgtcac aggctccctg ttcccagagt tggaagtcta cccgtttctt 7380 gtaggcgggg ttgggcaaag cgaaagtaac atcgttgaag agaatcttac cggctctggg 7440 cataaaattg cgagtgatgc ggaaaggctg tggtacttcc gctcgattgt tgatcacctg 7500 ggcagctagg acgatctcgt cgaaaccgtt gatgttgtgt cctacgatgt ataattctat 7560 gaaacgcggc gtgcctttga cgtgaggtag cttattgagc tcatcaaagg ttaggtctgt 7620 agggtcagat aaggcgtagt gttcgagagc ccattcgtgc aggtgaggat ttgcatgtag 7680 gaatgatgac caaagatcca ccgccagtgc tgtttgtaac tggtcccgat actgacgaaa 7740 atgctggcca attgccattt tttctggagt gacacagtag aaggttctgg ggtcttgttg 7800 ccatcgatcc cactttagtt taatggctag atcgtgggcc atgttgacga gacgctcttc 7860 tcctgagagt ttcatgacca gcatgaaagg aactagttgt ttgccaaagg accccatcca 7920 ggtgtaagtt tccacatcgt aggtcaggaa gagtctttct gtgcgaggat gagagccgat 7980 cgggaagaac tggatttcct gccaccagtt ggaggattgg ctgttgatgt gatggaagta 8040 gaagtttctg cggcgcgccg agcattcgtg tttgtgcttg tacagacggc cgcagtagtc 8100 gcagcgttgc acgggttgta tctcgtgaat gagctgtacc tggcttccct tgacgagaaa 8160 tttcagtggg aagccgaggc ctggcgattg tatctcgtgc tcttctatat tcgctgtatc 8220 ggcctgttca tcttctgttt cggtggtggt catgctgacg agcccccgcg ggaggcaagt 8280 ccagacctcg gcgcgggagg ggcggagctg aaggaccaga gcgcgcaggc tggagctgtc 8340 cagagtcctg agacgctgcg gactcaggtt agtaggtagg gacagaagat taacttgcat 8400 gatcttttcc agggcgtgcg ggaggttcag atggtacttg atttccacag gttcgtttgt 8460 agagatgtca atggcttgca gggttccgtg tcctttgggc gccactaccg tacctttgtt 8520 ttttcttttg atcggtggtg gctctcttgc ttcttgcatg ctcagaagcg atgacgggga 8580 cgcgcgccgg gcggaagcgg ttgttccgga cccggaggca tggctggtag tggcacgtcg 8640 gcgccgcgca cgggcaggtt ctggtactgc gctctgagaa gacttgcgtg cgccaccacg 8700 cgtcgattga cgtcttgtat ctgacgtctc tgggtgaaag ctaccggccc cgtgagcttg 8760 aacctgaaag agagttcaac agaatcaatt tcggtatcgt taacggcagc ttgtctcagt 8820 atttcttgta cgtcaccaga gttgtcctgg taggcgatct ccgccatgaa ctgctcgatt 8880 tcttcctcct gaagatctcc gcgacccgct ctctcgacgg tggccgcgag gtcattggag 8940 atacggccca tgagttggga gaatgcagtc atgcccgcct cgttccagac gcggctgtaa 9000 accacggccc cctcggagtc tcttgcgcgc atcaccacct gagcgaggtt aagctccacg 9060 tgtctggtga agaccgcata gttgcatagg cgctgaaaaa ggtagttgag tgtggtggca 9120 atgtgttcgg cgacgaagaa atacatgatc catcgtctca gcggcatttc gctgacatcg 9180 cccagagctt ccaagcgctc catggcctcg tagaagtcca cggcaaaatt aaaaaactgg 9240 gagtttcgcg cggacacggt caattcctcc tcgagaagac ggatgagttc ggctatggtg 9300 gcccgtactt cgcgttcgaa ggctcccggg atctcttctt cctcttctat ctcttcttcc 9360 actaacatct cttcttcgtc ttcaggcggg ggcggagggg gcacacggcg acgtcgacgg 9420 cgcacgggca aacggtcgat gaatcgttca atgacctctc cgcggcggcg gcgcatggtt 9480 tcagtgacgg cgcggccgtt ctcgcgcggt cgcagagtaa aaacaccgcc gcgcatctcc 9540 ttaaagtggt gactgggagg ttctccgttt gggagggaga gggcgctgat tatacatttt 9600 attaattggc ccgtagggac tgcgcgcaga gatctgatcg tgtcaagatc cacgggatct 9660 gaaaaccttt cgacgaaagc gtctaaccag tcacagtcac aaggtaggct gagtacggct 9720 tcttgtgggc gggggtggtt atgtgttcgg tctgggtctt ctgtttcttc ttcatctcgg 9780 gaaggtgaga cgatgctgct ggtgatgaaa ttaaagtagg cagttctaag acggcggatg 9840 gtggcgagga gcaccaggtc tttgggtccg gcttgctgga tacgcaggcg attggccatt 9900 ccccaagcat tatcctgaca tctagcaaga tctttgtagt agtcttgcat gagccgttct 9960 acgggcactt cttcctcacc cgttctgcca tgcatacgtg tgagtccaaa cccgcgcatt 10020 ggttgtacca gtgccaagtc agctacgact ctttcggcga ggatggcttg ctgtacttgg 10080 gtgagggtgg cttgaaagtc atcaaaatcc acaaagcggt ggtaagcccc ggtattaatg 10140 gtgtaagcac agttggccat gactgaccag ttaactgtct ggtgaccagg gcgcacgagc 10200 tcggtgtatt taaggcgcga ataggcgcgg gtgtcaaaga tgtaatcgtt gcaggtgcgc 10260 accagatact ggtaacctat aagaaaatgc ggcggtggtt ggcggtagag aggccatcgt 10320 tctgtagctg gagcgccggg ggcgaggtct tccaacataa ggcggtgata gccgtagatg 10380 tacctggaca tccaggtgat tcctgcggcg gtagtagaag cccgaggaaa ctcgcgtacg 10440 cggttccaaa tgttgcgtag cggcatgaag tagttcattg taggcacggt ttgaccagtg 10500 aggcgcgcgc agtcattgat gctctataga cacggagaaa atgaaagcgt tcagcgactc 10560 gactccgtag cctggaggaa cgtgaacggg ttgggtcgcg gtgtaccccg gttcgagact 10620 tgtactcgag ccggccggag ccgcggctaa cgtggtattg gcactcccgt ctcgacccag 10680 cctacaaaaa tccaggatac ggaatcgagt cgttttgctg gttgccgaat ggcagggaag 10740 tgagtcctat tttttttttt tgccgctcag atgcatcccg tgctgcgaca gatgcgtccc 10800 caacaacagc ccccctcgca gcagcagcaa ccacaaaagg ctgtccctgc aactactgca 10860 actgccgctg tgagcggtgc gggacagccc gcctatgatc tggacttgga agagggcgaa 10920 ggactggcac gtctaggtgc gccttcgccc gagcggcatc cgcgagttca actgaaaaaa 10980 gattctcgcg aggcgtatgt gccccaacag aacctattta gagacagaag cggcgaggag 11040 ccggaggaga tgcgagcttc ccgctttaac gcgggtcgtg agctgcgtca cggtttggac 11100 agaagacgag tgttgcggga cgaggatttc gaagttgatg aagtgacagg gatcagtcct 11160 gccagggcac acgtggctgc agccaacctt gtatcggctt acgaacagac agtaaaggaa 11220 gagcgtaatt tccaaaagtc ttttaataat catgtgcgaa ccctcattgc ccgcgaagaa 11280 gtcacccttg gtttgatgca tttgtgggat ttgatggaag ctatcattca gaaccctact 11340 agcaaacctc tgaccgcaca gctgtttctg gtggtgcaac acagcagaga caatgaggct 11400 ttcagagagg cgctgctcaa catcaccgaa cccgagggga gatggttgta tgatcttatc 11460 aacattctac agagtatcat agtgcaggag cggagcctgg gcctggccga gaaggtggct 11520 gccatcaatt actcggtttt gagcttggga aagtattacg ctcgcaagat ctacaagact 11580 ccatacgttc ccatagacaa ggaggtgaag atagatgggt tctacatgcg catgacgctg 11640 aaggtgttga ccctgagcga tgatcttggg gtgtaccgca atgacagaat gcatcgcgcg 11700 gtgagcgcca gcaggaggcg cgagttaagc gacagggaac tgatgcacag tttgcaaaga 11760 gctctaactg gagctggaac cgagggtgag aattactttg atatgggagc tgacttgcag 11820 tggcagccta gtcgcagggc tctgaacgcc gcgacggcag gatgtgagct tccttacata 11880 gaagaggcgg atgaaggcga ggaggaagag ggcgagtact tggaagactg atggcacaac 11940 ccgtgttttt tgctagatgg aacagcaagc accggatccc gcaatgcggg cggcgctgca 12000 gagccagccg tccggcatta actcctcgga cgattggacc caggccatgc aacgtatcat 12060 ggcgttgacg actcgcaacc ccgaagcctt tagacagcaa ccccaggcca accgtctatc 12120 ggccatcatg gaagctgtag tgccttcccg ctctaatccc actcatgaga aggtcctggc 12180 catcgtgaac gcgttggtgg agaacaaagc tattcgtcca gatgaggccg gactggtata 12240 caacgctctc ttagaacgcg tggctcgcta caacagtagc aatgtgcaaa ccaatttgga 12300 ccgtatgata acagatgtac gcgaagccgt gtctcagcgc gaaaggttcc agcgcgatgc 12360 caacctgggt tcgctggtgg cgttaaatgc tttcttgagt actcagcctg ctaatgtgcc 12420 gcgtggtcaa caggattata ctaacttttt aagtgctttg agactgatgg tatcagaagt 12480 acctcagagc gaagtatatc agtccggtcc tgattacttc tttcagacta gcagacaggg 12540 cttgcagacg gtaaatctga gccaagcttt taaaaacctt aaaggtttgt ggggagtgca 12600 tgccccggta ggagaaagag caaccgtgtc tagcttgtta actccgaact cccgcctatt 12660 attactgttg gtagctcctt tcaccgacag cggtagcatc gaccgtaatt cctatttggg 12720 ttacctacta aacctgtatc gcgaagccat agggcaaagt caggtggacg agcagaccta 12780 tcaagaaatt acccaagtca gtcgcgcttt gggacaggaa gacactggca gtttggaagc 12840 cactctgaac ttcttgctta ccaatcggtc tcaaaagatc cctcctcaat atgctcttac 12900 tgcggaggag gagaggatcc ttagatatgt gcagcagagc gtgggattgt ttctgatgca 12960 agagggggca actccgactg cagcactgga catgacagcg cgaaatatgg agcccagcat 13020 gtatgccagt aaccgacctt tcattaacaa actgctggac tacttgcaca gagctgccgc 13080 tatgaactct gattatttca ccaatgccat cttaaacccg cactggctgc ccccacctgg 13140 tttctacacg ggcgaatatg acatgcccga ccctaatgac ggatttctgt gggacgacgt 13200 ggacagcgat gttttttcac ctctttctga tcatcgcacg tggaaaaagg aaggcggcga 13260 tagaatgcat tcttctgcat cgctgtccgg ggtcattggt gctaccgcgg ctgagcccga 13320 gtctgcaagt ccttttccta gtctaccctt ttctctacac agtgtacgta gcagcgaagt 13380 gggtagaata agtcgcccga gtttaatggg cgaagaggag tacctaaacg attccttgct 13440 cagaccggca agagaaaaaa atttcccaaa caatggaata gaaagtttgg tggataaaat 13500 gagtagatgg aagacttatg ctcaggatca cagagacgag cctgggatca tggggactac 13560 aagtagagcg agccgtagac gccagcgcca tgacagacag aggggtcttg tgtgggacga 13620 tgaggattcg gccgatgata gcagcgtatt ggacttgggt gggagaggaa ggggcaaccc 13680 gtttgctcat ttgcgccctc gcttgggtgg tatgttgtaa aaaaaaataa aaaagaaaaa 13740 actcaccaag gccatggcga cgagcgtacg ttcgttcttc tttattatct gtgtctagta 13800 taatgaggcg agtcgtgcta ggcggagcgg tggtgtatcc ggagggtcct cctccttcgt 13860 acgagagcgt gatgcagcag cagcaggcga cggcggtgat gcaatcccca ctggaggctc 13920 cctttgtgcc tccgcgatac ctggcaccta cggagggcag aaacagcatt cgttactcgg 13980 aactggcacc tcagtacgat accaccaggt tgtatctggt ggacaacaag tcggcggaca 14040 ttgcttctct gaactatcag aatgaccaca gcaacttctt gaccacggtg gtgcaaaaca 14100 atgactttac ccctacggaa gccagcaccc agaccattaa ctttgatgaa cgatcgcggt 14160 ggggcggtca gctaaaaacc atcatgcata ctaacatgcc caacgtgaac gagtatatgt 14220 ttagtaacaa gttcaaagcg cgtgtgatgg tgtccagaaa acctcctgag ggtgttagag 14280 tagacgataa ttatgatcat aagcaagata ttctaaaata cgagtggttc gagtttactt 14340 tgccagaagg caacttttcg gtcactatga ctatcgactt gatgaacaat gccatcatag 14400 acaattactt gaaagtgggc agacagaatg gagtgttgga aagtgacatt ggtgttaagt 14460 tcgacactag gaacttcaag ttgggatggg atccagaaac taagttgatc atgcctgggg 14520 tttacaccta tgaggccttc catcctgaca tcgtattgct gcctggctgc ggagtggact 14580 ttaccgaaag ccgtctgagc aaccttcttg gcattagaaa gaaacaccca ttccaagagg 14640 gttttaagat cttgtatgag gatttagaag gaggaaatat tccagccctt ttggatgtag 14700 atgcttatga gaacagcaag aaagatcaaa aagccaaaat agaagctgct gcagaagcta 14760 aagcaaacat agttgccaac gatccggtaa gggtggctaa cgctagtgaa atcaggggag 14820 acagttttgc cgcaacatcc gttccgacta aagaatcatt attggatgat gtgtctcaaa 14880 acatagagtt aaaactcact attaagcctg tggaaaaaga tggcaaaaac agaagttaca 14940 atgtgttgga agataaaatc aacacggcct atcgcagttg gtacctttcg tacaattatg 15000 gcgaccccga aaaaggagtg cgttcctgga cattgctcac cacctcagat gtcacctgcg 15060 gagcggagca ggtctactgg tcgcttccag acatgatgca ggatcctgtc actttccgct 15120 ccactagaca agtcagtaac taccctgtgg tgggtgcaga gcttatgccc gtcttttcaa 15180 agagcttcta caacgaacaa gctgtgtact cccagcagct ccgccagtcc acctcgctta 15240 cgcacgtctt caaccgcttt cctgagaacc agattttaat ccgtccgccg gcgcccacaa 15300 ttaccaccgt cagtgaaaac gttcctgctc tcacagatca cgggaccctg ccgttgcgca 15360 gcagtatccg gggagtccaa cgtgtgaccg ttactgacgc cagacgccgc acctgtccct 15420 acgtgtacaa ggcactgggc atagtcgcac cgcgcgtcct ttcaagccgc actttctaaa 15480 aaaaaaaaaa aaatgtccgt tcttatctcg cccagtaata acaccggttg gggtctgcgc 15540 gctcccagca agatgtacgg aggcgcacgc aaacgttcta cccaacatcc cgtgcgtgtt 15600 cgcgggcatt ttcgcgctcc atggggtgcc ctcaagggcc gcactcgcgt tcgaaccacc 15660 gtcgatgatg taatcgatca ggtggttgcc gacgcccgta attatactcc tactgcgcct 15720 acatctactg tggacgcagt tattgacagt gtagtggctg acgctcgcaa ctatgctcga 15780 cgtaagagcc ggcgaaggcg cattgccaga cgtcaccgag ctaccactgc catgcgagca 15840 gcaagagctc tgctacgaag agctagacgc gtggggcgaa gagccatgct tagggcggcc 15900 agacgtgcag cttcgggcgc cagcgccggc aggtcccgca ggcaagcagc cgctgtcgca 15960 gcggcgacta ttgccgacat ggcccaatcg cgaagaggca atgtatactg ggtgcgtgac 16020 gctgccaccg gtcaacgtgt acccgtgcgc acccgtcccc ctcgcactta gaagatactg 16080 agcagtctcc gatgttgtgt cccagcggcg aggatgtcca agcgcaaata caaggaagaa 16140 atgctgcagg ttatcgcacc tgaagtctac ggccaaccgt tgaaggatga aaaaaaaccc 16200 cgcaaaatca agcgggtaaa aaaggacaaa aaagaagagg aagatggcga tgatgggctg 16260 gcggagtttg tgcgcgagtt tgccccacgg cgacgcgtgc aatggcgtgg gcgcaaagtt 16320 cgacatgtgt tgagacctgg aacttcggtg gtctttacac ccggcgagcg ttcaagcgct 16380 acttttaagc gttcctatga tgaggtgtac ggggatgatg atattcttga gcaggcagct 16440 gaccgattag gcgagtttgc ttatggcaag cgtagtagaa taaatcccaa ggatgaaaca 16500 gtgtccatac ccttggatca tggaaatccc acccctagtc ttaaaccggt cactttgcag 16560 caagtgttac ccgtaactcc gcgaacaggt gttaaacgcg aaggtgaaga tttgtatccc 16620 actatgcaac tgatggtgcc caaacgccag aagttggagg acgttttgga gaaagtaaaa 16680 gtggatccag atattcaacc tgaggttaaa gtgagaccca ttaagcaggt agcgcctggt 16740 ctgggagtac aaactgtaga cattaaaatt cccactgaaa gtatggaagt gcaaactgaa 16800 cccgcaaagc ctactgccac ctccactgaa gtgcaaacgg acccatggat gcccatgcct 16860 attacaactg acgccgtcgg tcccactcga agatcccgac gaaagtacgg tccagcaagt 16920 ctgttgatgc ccaactatgt cgtacaccca tctattattc ctactcctgg ttaccgaggc 16980 actcgctact atcgcagccg aaacagtact tcccgccgtc gccgcaagac acctgcaaat 17040 cgcagtcgtc gccgtagacg cacaagcaaa ccgattcccg gcgccctggt gcggcaagtg 17100 taccgcaatg gtagtgcgga acctttgaca ctgccgcgtg cgcgttacca tcctagtatc 17160 atcacttaat caatgttgcc gctgcctcct tgcagatatg gccctcactt gtcgccttcg 17220 cgttcccatc actggttacc gaggaagaaa ctcgcgccgt agaagaggga tgttggggcg 17280 cggaatgcga cgctacaggc gacggcgtgc tatccgcaag caattgcggg gtggtttttt 17340 gccagcctta attccaatta tcgctgctgc gattggcgca ataccaggca tagcttccgt 17400 ggcggttcag gcctcgcaac gacattgaca ttggaaaaaa aaaaaacgta taaataaaaa 17460 atacaatgga ctctgacact cctggtactg tgactatgtt ttcttagaga tggaagacat 17520 caatttttca tccttggctc cgcgacacgg cacgaagccg tacatgggca cctggagcga 17580 catcggcacg agccaactga acgggggcgc cttcaattgg agcagtatct ggagcgggct 17640 taaaaatttt ggctcaacca taaaaacata cgggaacaaa gcttggaaca gcagtacagg 17700 acaggcgctt agaaataaac ttaaagacca gaacttccaa caaaaagtag tcgatgggat 17760 agcttccggt atcaatggag tggtagattt ggctaaccag gctgtgcaga aaaagataaa 17820 cagtcgtttg gacccgccgc cagcaacccc aggtgaaatg caagtggagg aagaaattcc 17880 tccgccagaa aaacgaggcg acaagcgtcc gcgtcccgat ttggaagaga cgctggtgac 17940 gcgcgtagat gaaccgcctt cttatgagga agcaacgaag cttggaatgc ccaccactag 18000 accgatagcc cctatggcca ccggggtgat gaaaccttct cagttgcatc gacccgtcac 18060 cttggatttg ccccctcctc ctgctgctac tgctgtaccc gcttctaagc ctgtcgctgc 18120 cccgaaacca gtcgccgtag ccaggtcacg tcccgggggc gctcctcgtc caaatgcaca 18180 ctggcaaaat actctgaaca gcatcgtggg tctaggcgtg caaagtgtaa aacgccgtcg 18240 ctgcttttaa ttaaatatgg agtagcgctt aacttgccta tctgtgtata tgtgtcatta 18300 cacgccgtca cagcatcaga ggaaaaaagg aagaggtcgt gcgtcgacgc tgagttactt 18360 tcaagatggc caccccatcg atgctgcccc aatgggcata catgcacatc gccggacagg 18420 atgcttcgga gtacctgagt ccgggtctgg tgcagttcgc ccgcgccaca gacacctact 18480 tcaatctggg aaataagttt agaaatccta ccgtagcgcc gacccacgat gtgaccaccg 18540 atcgtagcca gcggctcatg ttgcgcttcg tgcccgttga ccgggaggac aatacatact 18600 cttacaaagt gcggtacacc ctggccgtgg gcgacaacag agtgctggat atggccagca 18660 cgttctttga cattaggggc gtgttggaca gaggtcccag ttttaaaccc tattctggta 18720 cggcttacaa ctccctggct cctaaaggcg ctccaaatgc atctcagtgg ttggataagg 18780 gagttacaag cactggccta gtggacgacg gcaatactga tgatggggaa gaagccaaaa 18840 aagcaacata cacttttggt aatgctccag taaaagccga ggctgaaatc acaaaagacg 18900 gattgccggt gggcttggaa gtttcaactg aaggtcctaa accaatctat gctgataagc 18960 tttatcagcc agaacctcaa gtgggagacg aaacttggac tgacctagac ggaaaaaccg 19020 aagagtatgg agggagggtt cttaaacctg aaactaaaat gaaaccctgc tacggatctt 19080 ttgctaaacc tactaatatt aaaggaggtc aggcaaaggt aaaaccaaaa gaagacgatg 19140 gcactaacaa catcgagtat gacattgaca tgaacttctt tgacttaaga tcacaaagat 19200 cagaactcaa acctaaaatt gtaatgtatg cagaaaatgt ggacctggaa tgtccagata 19260 ctcatgttgt gtacaaacct ggagtttcag atgctagttc tgagaccaat cttggacaac 19320 agtctatgcc caacagaccc aactacattg gcttcagaga taacttcatc ggacttatgt 19380 actataacag tactggcaac atgggggtac tggctggcca agcgtctcag ttgaatgcag 19440 tggttgactt gcaggacaga aacacagaac tgtcttacca actcttgctt gactctctgg 19500 gcgacagaac cagatacttt agcatgtgga atcaggctgt ggacagttat gatcctgatg 19560 tacgtgttat tgaaaatcat ggtgtggaag atgaacttcc caactattgt tttccgttgg 19620 atggtgtcgg tccgcgaaca gatagttaca aggagattaa gccaaatgga gaccaatcta 19680 cttggacaaa tgtagaccca actggcagca gtgaacttgc taagggaaat ccatttgcca 19740 tggaaattaa ccttcaagcc aatctatggc gaagtttcct ttattccaat gtggctctat 19800 atctcccaga ctcgtacaaa tacaccccgt ccaatgtcac tcttccagaa aacaaaaaca 19860 cctacgacta catgaacggg cgggtggtgc cgccatctct agtagacacc tatgtgaaca 19920 ttggtgccag gtggtctctg gatgccatgg acaatgtcaa cccattcaac caccaccgta 19980 acgctggctt gcgttaccga tccatgcttc tgggtaacgg acgttatgtg cctttccaca 20040 tacaagtgcc tcaaaaattc ttcgctgtta aaaacctgct gcttctccca ggctcctaca 20100 cttatgagtg gaactttagg aaggatgtaa acatggttct acagagttcc ctcggtaacg 20160 acctacgggt agatggcgcc agcatcagtt ttacgagcat caacctctat gctacttttt 20220 tccccatggc tcacaacacc gcttccaccc ttgaagccat gctgcggaat gacaccaatg 20280 atcagtcatt caacgactac ctatctgcag ctaacatgct ctaccccatt cctgccaatg 20340 caaccaatat tcccatttcc attccttctc gcaactgggc ggctttcaga ggctggtcat 20400 ttaccagact gaaaaccaaa gaaactccct ctttggggtc tggatttgac ccctacttcg 20460 tctattctgg ttctattccc tacctggatg gtaccttcta cctgaaccac acttttaaga 20520 aggtttccat catgtttgac tcttcagtga gctggcctgg aaatgacagg ttactatctc 20580 ctaacgaatt tgaaataaag cgcactgtgg atggcgaagg ctacaacgta gcccaatgca 20640 acatgaccaa agactggttc ttggtacaga tgctcgccaa ctacaacatc ggctatcagg 20700 gcttctacat tccagaagga tacaaagatc gcatgtattc atttttcaga aacttccagc 20760 ccatgagcag gcaggtggtt gatgaggtca attacaaaga cttcaaggcc gtcgccatac 20820 cctaccaaca caacaactct ggctttgtgg gttacatggc tccgaccatg cgtcaaggtc 20880 aaccctatcc cgctaactat ccctatccac tcattggaac aactgccgta aatagtgtta 20940 cgcagaaaaa gttcttgtgt gacagaacca tgtggcgcat accgttctca agcaacttca 21000 tgtctatggg agcccttaca gacttgggac agaacatgct ctatgccaac tcagctcatg 21060 ctctggacat gacctttgag gtggatccca tggatgagcc caccctgctt tatcttctct 21120 tcgaagtttt cgacgtggtc agagtgcatc agccacaccg cggcatcatc gaggcagtct 21180 acctgcgtac accgttctcg gccggtaacg ctaccacgta agaagcttct tgcttcttgc 21240 aaacagcagc tgcaaccatg gcctgcggat cccaaaacgg ctccagcgag caagagctca 21300 gagccattgt ccaagacctg ggttgcggac catatttttt gggaaccttt gataagcgct 21360 tcccggggtt catggccccc gataagctcg cctgtgccat tgtaaatacg gccggacgtg 21420 agacgggggg agagcactgg ttggctttcg gttggaaccc acgttctaac acctgctacc 21480 tttttgatcc ttttggattc tcggatgatc gtctcaaaca gatttaccag tttgaatatg 21540 agggtctcct gcgccgcagc gctcttgcta ccaaggaccg gtgtattacg ctggaaaaat 21600 ctacccagac cgtgcagggc ccccgttctg ccgcctgcgg acttttctgc tgcatgttcc 21660 ttcatgcctt tgtgcactgg cctgaccgtc ccatggacgg aaaccccacc atgaaattgc 21720 taactggagt gccaaacaac atgcttcatt ctcctaaagt ccagcccacc ctgtgtgaca 21780 atcaaaaagc actctaccat tttctcaata cccattcgcc ttattttcgc tctcatcgta 21840 cacacatcga aagggccact gcgttcgacc gtatggatgt gcaataatga ttcatgtaaa 21900 caacgtgttc aataaacagc actttatttt ttacatgtat cgaggctctg gattacttat 21960 ttatttacaa gtcgaatggg ttctgacgag aatcagaatg acccgcaggc agtgatacgt 22020 tgcggaactg atacttgggt tgccacttga attcgggaat caccaacttg ggaaccggta 22080 tatcgggcag gatgtcactc cacagctttc tggtcagctg caaagctccc agcaggtcag 22140 gagccgaaat cttgaaatca caattaggac cagtgctctg agcgcgagag ttgcggtaca 22200 ccggattgca gcactgaaac accatcagcg acggatgtct tacgcttgcc agcacggtgg 22260 gatctgcaat catgcccaca tccagatctt cagcattggc aatgctgaac ggggtcatct 22320 tgcaggtctg cctacccatg gcgggcaccc aattaggctt gtggttacaa tcgcagtgca 22380 gggggatcag tatcatcttg gcctgatcct gtctgattcc tggatacacg gctctcatga 22440 aagcatcata ttgcttgaaa gcctgctggg ctttactacc ctcggtataa aacatcccgc 22500 aggacctgct cgaaaactgg ttagctgcgc agccggcatc attcacacag cagcgggcgt 22560 cattgttggc tatttgcacc acacttctgc cccagcggtt ttgggtgatt ttggttcgct 22620 cgggattctc cttcaaggct cgttgtccgt tctcgctggc cacatccatc tcgataatct 22680 gctccttctg aatcataata ttgccatgca agcacttcag cttgccctca taatcattgc 22740 agccatgagg ccacaacgca cagcctgtac attcccaatt atggtgggcg atctgagaaa 22800 aagaatgtat cattccctgc agaaatcttc ccatcatcgt gctcagtgtc ttgtgactag 22860 tgaaagttaa ctggatgcct cggtgctcct cgttcacgta ctggtgacag atgcgcttgt 22920 attgttcgtg ctgctcaggc attagtttaa aagaggttct aagttcgtta tccagcctgt 22980 acttctccat cagcagacac atcacttcca tgcctttctc ccaagcagac accaggggca 23040 agctaatcgg attcttaaca gtgcaggcag cagctccttt agccagaggg tcatctttgg 23100 cgatcttctc aatgcttctt ttgccatcct tctcaacgat gcgcacgggc gggtagctga 23160 aacccactgc tacaagttgc gcctcttctc tttcttcttc gctgtcttga ctgatgtctt 23220 gcatggggac atgtttggtc ttccttggct tctttttcgg gggtatcgga ggaggaggac 23280 tgtcgctccg ttccggagac agggaggatt gtgacgtttc gctcaccatt accaactgac 23340 tgtcggtaga agaacctgac cccacacggc gacaggtgtt tctcttcggg ggcagaggtg 23400 gaggcgattg cgaagggctg cggtccgacc tggaaggcgg atgactggca gaaccccttc 23460 cgcgttcggg ggtgtgctcc ctgtggcggt cgcttaactg atttccttcg cggctggcca 23520 ttgtgttctc ctaggcagag aaacaacaga catggaaact cagccattgc tgtcaacatc 23580 gccacgagtg ccatcacatc tcgtcctcag cgacgaggaa aaggagcaga gcttaagcat 23640 tccaccgccc agtcctgcca ccacctctac cctagaagat aaggaggtcg acgcatctca 23700 tgacatgcag aataaaaaag cgaaagagtc tgagccagac atcgaacaag acccgggcta 23760 tgtgacaccg gtggaacacg aggaagagtt gaaacgcttt ctagagagag aggatgaaaa 23820 ctgcccaaaa cagcaagcgg ataactatca ccaagatgct ggaaataggg atcagaacac 23880 cgactacctc atagggcttg acggggaaga cgcgctcctt aaacatctag caagacagtc 23940 actcatagtc aaggatgcat tattggacag aactgaagtg cccatcagtg tcgaagagct 24000 cagccgcgcc tacgagctta acctattttc acctcgtact ccccccaaac gtcagccaaa 24060 cggcacctgc gagccaaatc ctcgcttaaa cttttatcca gcttttgctg tgccagaagt 24120 actggctacc tatcacatct tttttaaaaa tcaaaaaatt ccagtctcct gccgcgctaa 24180 tcgcacccgc gccgatgccc tactcaatct gggacctggt tcacgcttac ctgatatagc 24240 ttccttggaa gaggttccaa agatcttcga gggtctgggc aataatgaga ctcgggccgc 24300 aaatgctctg caaaagggag aaaatggcat ggatgagcat cacagcgttc tggtggaatt 24360 ggaaggcgat aatgccagac tcgcagtact caagcgaagc gtcgaggtca cacactttgc 24420 ataccccgct gtcaacctgc cccctaaagt catgacggcc gtcatggacc agttactcat 24480 taagcgcgca agtccccttt cagaagacat gcatgaccca gatgcctgtg atgagggtaa 24540 accagtggtc agtgatgagc agctaacccg atggctgggc accgactctc cccgggattt 24600 ggaagagcgt cgcaagctta tgatggccgt ggtgctggtt accgtagaac tagagtgtct 24660 tcggcgtttc tttaccgatt cagaaacctt gcgcaaactc gaagagaatc tgcactacac 24720 ttttagacac ggctttgtgc ggcaggcatg caagatatct aacgtggaac tcaccaacct 24780 ggtttcctac atgggtattc tgcatgagaa tcgcctagga caaagcgtgc tgcacagcac 24840 ccttaagggg gaagcccgcc gtgattacat ccgcgattgt gtttatctct acctgtgcca 24900 cacgtggcaa accggcatgg gtgtatggca gcaatgttta gaagaacaga acctgaaaga 24960 gctaaacaag ctcttacaga aatctcttaa ggttctgtgg acagggttcg acgagcgcac 25020 cgtcgcttcc gacctggcag acctcatctt cccagagcgt ctcagggtta ctttgcgaaa 25080 cggactgcct gactttatga gccagagcat gcttaacaat tttcgctctt tcatcctgga 25140 acgctccggt atcctgcccg ccacctgctg cgcactgccc tccgactttg tgcctctcac 25200 ctaccgcgaa tgccccccgc cgctatggag tcactgctac ctgttccgtc tggccaacta 25260 cctctcctac cactcggatg tgatcgagga tgtgagcgga gacggcttgc tggagtgtca 25320 ctgccgctgc aatctgtgca cgccccaccg gtccctagct tgcaaccccc agttgatgag 25380 cgaaacccag ataataggca cctttgaatt gcaaggcccc agcagccaag gcgatgggtc 25440 ttctcctggg caaagtttaa aactgacccc gggactgtgg acctccgcct acttgcgcaa 25500 gtttgccccg gaagattacc acccctatga aatcaagttc tatgaggacc aatcacagcc 25560 tccgaaagcc gaactttcgg cctgcgtcat cacccagggg gcaattctgg cccaattgca 25620 agccatccaa aaatcccgcc aagaatttct actgaaaaag ggtaaggggg tctaccttga 25680 cccccagacc ggcgaggaac tcaacacaag gttccctcag gatgtcccaa cgacgagaaa 25740 gcaagaagtt gaaggtgcag ccgccgcccc cagaagatat ggaggaagat tgggacagtc 25800 aggcagagga agcggaggag gaggacagtc tggaggacag tctggaggaa gacagtttgg 25860 aggaggaaaa cgaggaggca gaggaggtgg aagaagtaac cgccgacaaa cagttatcct 25920 cggctgcgga gacaagcaac agcgctacca tctccgctcc gagtcgagga acccggcggc 25980 gtcccagcag tagatgggac gagaccggac gcttcccgaa cccaaccagc gcttccaaga 26040 ccggtaagaa ggatcggcag ggatacaagt cctggcgggg gcataagaat gccatcatct 26100 cctgcttgca tgagtgcggg ggcaacatat ccttcacgcg gcgctacttg ctattccacc 26160 atggggtgaa ctttccgcgc aatgttttgc attactaccg tcacctccac agcccctact 26220 atagccagca aatcccggca gtctcgacag ataaagacag cggcggcgac ctccaacaga 26280 aaaccagcag cggcagttag aaaatacaca acaagtgcag caacaggagg attaaagatt 26340 acagccaacg agccagcgca aacccgagag ttaagaaatc ggatctttcc aaccctgtat 26400 gccatcttcc agcagagtcg gggccaagag caggaactga aaataaaaaa ccgatctctg 26460 cgttcgctca ccagaagttg tttgtatcac aagagcgaag atcaacttca gcgcactctc 26520 gaggacgccg aggctctctt caacaagtac tgcgcgctga ctcttaaaga gtaggcagcg 26580 accgcgctta ttcaaaaaag gcgggaatta catcatcctc gacatgagta aagaaattcc 26640 cacgccttac atgtggagtt atcagcccca aatgggattg gcggcaggcg cctcccagga 26700 ctactccacc cgcatgaatt ggctcagcgc cgggccttct atgatttctc gagttaatga 26760 tatacgcgcc taccgaaacc aaatactttt ggaacagtca gctcttacca ccacgccccg 26820 ccaacacctt aatcccagaa attggcccgc cgccctagtg taccaggaaa gtcccgctcc 26880 caccactgta ttacttcctc gagacgccca ggccgaagtc caaatgacta atgcaggtgc 26940 gcagttagcg ggcggctcca ccctatgtcg tcacaggcct cggcataata taaaacgcct 27000 gatgatcaga ggccgaggta tccagctcaa cgacgagtcg gtgagctctc cgcttggtct 27060 acgaccagac ggaatctttc agattgccgg ctgcgggaga tcttccttca cccctcgtca 27120 ggctgttctg actttggaaa gttcgtcttc gcaaccccgc tcgggcggaa tcgggaccgt 27180 tcaatttgtg gaggagttta ctccctctgt ctacttcaac cccttctccg gatctcctgg 27240 gcactacccg gacgagttca taccgaactt cgacgcgatt agcgagtcag tggacggcta 27300 cgattgagtt tatgttaagt ggagaggcag agcaactgcg cctgaaacac ctggtccact 27360 gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt gaattgcccg 27420 aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga gagcttgccc 27480 gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac aggggaccct 27540 gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat ctttgttgcc 27600 atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc ctatcgccat 27660 cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt acctggtact 27720 tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt gagtctacga 27780 gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct tacctgccgg 27840 gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg taaaccagac 27900 tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc ttagaaaacc 27960 cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt caagcaactc 28020 tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc tctgtcttgt 28080 gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct gctgtgtgca 28140 catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat gattaggtac 28200 ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa ggtggatttt 28260 aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac cactcttata 28320 aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat tggcaagtat 28380 gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac agttttccag 28440 ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg cgacattacc 28500 atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga aaacactggc 28560 actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac cctactctat 28620 attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta atttactaag 28680 ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca aattcaaaaa 28740 gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct caataccatt 28800 cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg aagtcaggct 28860 tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt tccagtccaa 28920 ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc cgctaccgga 28980 cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg ggataacttg 29040 ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat gtggctcatc 29100 tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat tgtgctacac 29160 ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt ttctcttaca 29220 gtatgattaa atgagacatg attcctcgag tttttatatt actgaccctt gttgcgcttt 29280 tttgtgcgtg ctccacattg gctgcggttt ctcacatcga agtagactgc attccagcct 29340 tcacagtcta tttgctttac ggatttgtca ccctcacgct catctgcagc ctcatcactg 29400 tggtcatcgc ctttatccag tgcattgact gggtctgtgt gcgctttgca tatctcagac 29460 accatcccca gtacagggac aggactatag ctgagcttct tagaattctt taattatgaa 29520 atttactgtg acttttctgc tgattatttg caccctatct gcgttttgtt ccccgacctc 29580 caagcctcaa agacatatat catgcagatt cactcgtata tggaatattc caagttgcta 29640 caatgaaaaa agcgatcttt ccgaagcctg gttatatgca atcatctctg ttatggtgtt 29700 ctgcagtacc atcttagccc tagctatata tccctacctt gacattggct ggaacgcaat 29760 agatgccatg aaccacccaa ctttccccgc gcccgctatg cttccactgc aacaagttgt 29820 tgccggcggc tttgtcccag ccaatcagcc tcgcccacct tctcccaccc ccactgaaat 29880 cagctacttt aatctaacag gaggagatga ctgacaccct agatctagaa atggacggaa 29940 ttattacaga gcagcgcctg ctagaaagac gcagggcagc ggccgagcaa cagcgcatga 30000 atcaagagct ccaagacatg gttaacttgc accagtgcaa aaggggtatc ttttgtctgg 30060 taaagcaggc caaagtcacc tacgacagta ataccaccgg acaccgcctt agctacaagt 30120 tgccaaccaa gcgtcagaaa ttggtggtca tggtgggaga aaagcccatt accataactc 30180 agcactcggt agaaaccgaa ggctgcattc actcaccttg tcaaggacct gaggatctct 30240 gcacccttat taagaccctg tgcggtctca aagatcttat tccctttaac taataaaaaa 30300 aaataataaa gcttaatcac ttacttgaaa tcagcaataa ggtctctgtt gaaattttct 30360 cccagcagca cctcacttcc ctcttcccaa ctctggtatt ctaaaccccg ttcagcggca 30420 tactttctcc atactttaaa ggggatgtca aattttagct cctctcctgt acccacaatc 30480 ttcatgtctt tcttcccaga tgaccaagag agtccggctc agtgactcct tcaaccctgt 30540 ctacccctat gaagatgaaa gcacctccca acaccccttt ataaacccag ggtttatttc 30600 cccaaatggc ttcacacaaa gcccagacgg agttcttact ttaaaatgtt taaccccact 30660 aacaaccaca ggcggatctc tacagctaaa agtgggaggg ggacttacag tggatgacac 30720 tgatggtacc ttacaagaaa acatacgtgc tacagcaccc attactaaaa ataatcactc 30780 tgtagaacta tccattggaa atggattaga aactcaaaac aataaactat gtgccaaatt 30840 gggaaatggg ttaaaattta acaacggtga catttgtata aaggatagta ttaacacctt 30900 atggactgga ataaaccctc cacctaactg tcaaattgtg gaaaacacta atacaaatga 30960 tggcaaactt actttagtat tagtaaaaaa cggagggctt gttaatggct acgtgtctct 31020 agttggtgta tcagacactg tgaaccaaat gttcacacaa aagacagcaa acatccaatt 31080 aagattatat tttgactctt ctggaaatct attaactgat gaatcagact taaaaattcc 31140 acttaaaaat aaatcttcta cagcgaccag tgaaactgta gccagcagca aagcctttat 31200 gccaagtact acagcttatc ccttcaacac cactactagg gatagtgaaa actacattca 31260 tggaatatgt tactacatga ctagttatga tagaagtcta tttcccttga acatttctat 31320 aatgctaaac agccgtatga tttcttccaa tgttgcctat gccatacaat ttgaatggaa 31380 tctaaatgca agtgaatctc cagaaagcaa catagctacg ctgaccacat cccccttttt 31440 cttttcttac attacagaag acgacaacta ataaagaatc gtttgtgtta tgtttcaacg 31500 tgtttatttt tcaattgcag aaaatttcga atcatttttc attcagtagt atagccccac 31560 caccacatag cttatacaga tcaccgtacc ttaatcaaac tcacagaacc ctagtattca 31620 acctgccacc tccctcccaa cacacagagt acacagtcct ttctccccgg ctggccttaa 31680 aaagcatcat atcatgggta acagacatat tcttaggtgt tatattccac acggtttcct 31740 gtcgagccaa acgctcatca gtgatattaa taaactcccc gggcagctca cttaagttca 31800 tgtcgctgtc cagctgctga gccacaggct gctgtccaac ttgcggttgc ttaacgggcg 31860 gcgaaggaga agtccacgcc tacatggggg tagagtcata atcgtgcatc aggatagggc 31920 ggtggtgctg cagcagcgcg cgaataaact gctgccgccg ccgctccgtc ctgcaggaat 31980 acaacatggc agtggtctcc tcagcgatga ttcgcaccgc ccgcagcata aggcgccttg 32040 tcctccgggc acagcagcgc accctgatct cacttaaatc agcacagtaa ctgcagcaca 32100 gcaccacaat attgttcaaa atcccacagt gcaaggcgct gtatccaaag ctcatggcgg 32160 ggaccacaga acccacgtgg ccatcatacc acaagcgcag gtagattaag tggcgacccc 32220 tcataaacac gctggacata aacattacct cttttggcat gttgtaattc accacctccc 32280 ggtaccatat aaacctctga ttaaacatgg cgccatccac caccatccta aaccagctgg 32340 ccaaaacctg cccgccggct atacactgca gggaaccggg actggaacaa tgacagtgga 32400 gagcccagga ctcgtaacca tggatcatca tgctcgtcat gatatcaatg ttggcacaac 32460 acaggcacac gtgcatacac ttcctcagga ttacaagctc ctcccgcgtt agaaccatat 32520 cccagggaac aacccattcc tgaatcagcg taaatcccac actgcaggga agacctcgca 32580 cgtaactcac gttgtgcatt gtcaaagtgt tacattcggg cagcagcgga tgatcctcca 32640 gtatggtagc gcgggtttct gtctcaaaag gaggtagacg atccctactg tacggagtgc 32700 gccgagacaa ccgagatcgt gttggtcgta gtgtcatgcc aaatggaacg ccggacgtag 32760 tcatatttcc tgaagcaaaa ccaggtgcgg gcgtgacaaa cagatctgcg tctccggtct 32820 cgccgcttag atcgctctgt gtagtagttg tagtatatcc actctctcaa agcatccagg 32880 cgccccctgg cttcgggttc tatgtaaact ccttcatgcg ccgctgccct gataacatcc 32940 accaccgcag aataagccac acccagccaa cctacacatt cgttctgcga gtcacacacg 33000 ggaggagcgg gaagagctgg aagaaccatg tttttttttt tattccaaaa gattatccaa 33060 aacctcaaaa tgaagatcta ttaagtgaac gcgctcccct ccggtggcgt ggtcaaactc 33120 tacagccaaa gaacagataa tggcatttgt aagatgttgc acaatggctt ccaaaaggca 33180 aacggccctc acgtccaagt ggacgtaaag gctaaaccct tcagggtgaa tctcctctat 33240 aaacattcca gcaccttcaa ccatgcccaa ataattctca tctcgccacc ttctcaatat 33300 atctctaagc aaatcccgaa tattaagtcc ggccattgta aaaatctgct ccagagcgcc 33360 ctccaccttc agcctcaagc agcgaatcat gattgcaaaa attcaggttc ctcacagacc 33420 tgtataagat tcaaaagcgg aacattaaca aaaataccgc gatcccgtag gtcccttcgc 33480 agggccagct gaacataatc gtgcaggtct gcacggacca gcgcggccac ttccccgcca 33540 ggaaccatga caaaagaacc cacactgatt atgacacgca tactcggagc tatgctaacc 33600 agcgtagccc cgatgtaagc ttgttgcatg ggcggcgata taaaatgcaa ggtgctgctc 33660 aaaaaatcag gcaaagcctc gcgcaaaaaa gaaagcacat cgtagtcatg ctcatgcaga 33720 taaaggcagg taagctccgg aaccaccaca gaaaaagaca ccatttttct ctcaaacatg 33780 tctgcgggtt tctgcataaa cacaaaataa aataacaaaa aaacatttaa acattagaag 33840 cctgtcttac aacaggaaaa acaaccctta taagcataag acggactacg gccatgccgg 33900 cgtgaccgta aaaaaactgg tcaccgtgat taaaaagcac caccgacagc tcctcggtca 33960 tgtccggagt cataatgtaa gactcggtaa acacatcagg ttgattcaca tcggtcagtg 34020 ctaaaaagcg accgaaatag cccgggggaa tacatacccg caggcgtaga gacaacatta 34080 cagcccccat aggaggtata acaaaattaa taggagagaa aaacacataa acacctgaaa 34140 aaccctcctg cctaggcaaa atagcaccct cccgctccag aacaacatac agcgcttcca 34200 cagcggcagc cataacagtc agccttacca gtaaaaaaga aaacctatta aaaaaacacc 34260 actcgacacg gcaccagctc aatcagtcac agtgtaaaaa agggccaagt gcagagcgag 34320 tatatatagg actaaaaaat gacgtaacgg ttaaagtcca caaaaaacac ccagaaaacc 34380 gcacgcgaac ctacgcccag aaacgaaagc caaaaaaccc acaacttcct caaatcgtca 34440 cttccgtttt cccacgttac gtcacttccc attttaagaa aactacaatt cccaacacat 34500 acaagttact ccgccctaaa acctacgtca cccgccccgt tcccacgccc cgcgccacgt 34560 cacaaactcc accccctcat tatcatattg gcttcaatcc aaaataaggt atattattga 34620 tgatgtaggg ataacagggt aat 34643 <210> 79 <211> 32273 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO185) <400> 79 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattaaac cgtattaccg ccatgcatta gttattaata 480 gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact 540 tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat 600 gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta 660 tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc 720 tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg 780 ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg 840 gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct 900 ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa 960 atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt 1020 ctatataagc agagctggtt tagtgaaccg tcagatccgc tagcgctacc ggactcagat 1080 ctcgagctca agcttcgaat tctgcagtcg acggtaccgg atccatggtg agcaagggcg 1140 aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc 1200 acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag ctgaccctga 1260 agttcatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg accaccctga 1320 cctacggcgt gcagtgcttc agccgctacc ccgaccacat gaagcagcac gacttcttca 1380 agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag gacgacggca 1440 actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac cgcatcgagc 1500 tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg gagtacaact 1560 acaacagcca caacgtctat atcatggccg acaagcagaa gaacggcatc aaggtgaact 1620 tcaagatccg ccacaacatc gaggacggca gcgtgcagct cgccgaccac taccagcaga 1680 acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg agcacccagt 1740 ccgccctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg gagttcgtga 1800 ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtaaagcgac tctagatcat 1860 aatcagccat accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc 1920 cctgaacctg aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta 1980 taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact 2040 gcattctagt tgtggtttgt ccaaactcat caatgtaagt ttaaacggcg cgcctgaaat 2100 gtgtgggcgt ggcttaaggg tgggaaagaa tatataaggt gggggtctta tgtagttttg 2160 tatctgtttt gcagcagccg ccgccgccat gagcaccaac tcgtttgatg gaagcattgt 2220 gagctcatat ttgacaacgc gcatgccccc atgggccggg gtgcgtcaga atgtgatggg 2280 ctccagcatt gatggtcgcc ccgtcctgcc cgcaaactct actaccttga cctacgagac 2340 cgtgtctgga acgccgttgg agactgcagc ctccgccgcc gcttcagccg ctgcagccac 2400 cgcccgcggg attgtgactg actttgcttt cctgagcccg cttgcaagca gtgcagcttc 2460 ccgttcatcc gcccgcgatg acaagttgac ggctcttttg gcacaattgg attctttgac 2520 ccgggaactt aatgtcgttt ctcagcagct gttggatctg cgccagcagg tttctgccct 2580 gaaggcttcc tcccctccca atgcggttta aaacataaat aaaaaaccag actctgtttg 2640 gatttggatc aagcaaaatg cacacacgct tatgcttaat aaaggtgttt attacttatt 2700 tgcgagtttg tcacattttt tactatatgc ggtgttccac ctttgtcgct gacgaaggac 2760 tttgtctatt ttttctagta gctggtaaag aatagtttgc acatttaggt acataggcat 2820 taaaccgttt tgggggtgaa ggtacatcca ttgcatacat tcatgttcgg gggaggtgtt 2880 atagatgatc cagtcgtaat ttatgtggtt agcgttatga tgaaaaatat cttttagcaa 2940 aagggtaata gcagtaggca tggctttagt gtaggtgtta atgaagcgag caacttggga 3000 aggttgcatt ttggggctaa tgatgtggca tttgctttgg atttttaaag tagcaatgtt 3060 gcccgcctgg tcttttctgg ggttcatgtt gtgcagcact acgaaaacag agtaaccggt 3120 acactgggga aaacgatcgt gtagctttga aggaaaggca tggaaaaatt ttgcaatgct 3180 tttatgtttt cccaattcct ccatacactc atccacaata atacaaatgg gacctctttg 3240 ggccgcttgg gcaaaaatgt tttgggggtg tgtaacatcg tagttgtggt ctgctgtaag 3300 gtcatcgtag gtgagtgtaa tgagtcgagg ttttaaagtt ccgcttttag gaacaatggt 3360 ctgttgcgga ccgcatgtat agtttccttc aactagttgt gcattccacg ctgacatttc 3420 ttgcgggggt atcatgtcga tttgaggaac cacaaaaaaa acggtttcgg gtgaaggatc 3480 tattaaatga caggaaagaa ggttgcggag caattgcgac tttccgcttc ctgtgggccc 3540 gtacacaatt gcaatcaggg gttgcaaaga atagtttaac gattcgcagt tgccttctgg 3600 acttaaaagc ggagctgcac tatttagcga tttacatagg atctcataat catgttttag 3660 ttcttgaagg agacctttgc ctgctaaggc cgctaagtct tcaacagtct caaagttcat 3720 gaggggcttt agtccttcgg aaaggggcaa gttggataga gtgtgctgca ggcactggag 3780 gcgaggccaa aggaattgca gttcctcgcc tacaaggcaa tccaggttgt ttccctgttc 3840 cggggattgg ggtgggcagt ggagtatgga attagacgac cgtcctccag gagagctaaa 3900 gttgggttct gccacgggcg aagagagcga gtcagcactg tctccgttac ggtgaaagcc 3960 gattcttgct tgttcatgtt caccaaggtt ctctttagac tctgtcggga agtgtagaag 4020 ttggggtcag attcattaag acggtatgct tcgtagcacg ctagtaagat gtcgtaggat 4080 aacgaagcaa cagcatgacc cttggcccgg agttttccag ctccttcttg accacaggtt 4140 gggcacacta atttctgtaa ggcgtagagt tttggagcaa gaaaaaccgt tcggggacta 4200 aatgcatcgc tcccgcagta tttacactga gtttcacatt ccactagcca tgtaagactc 4260 ggcttttcag ggttaaaaac gagcttacct ccgttcttct taagacggtg ttttccccgg 4320 gattccatga ggtttcgccc cgcttcggtg acaaacaggc tatcagtgtc accgtacaca 4380 ctttttataa gtcgtttttc aagttgaaga cctcggtcac tttcgtagag tatgtcactc 4440 cactcactca taaacccacg agtccaagcg agcacaaaag aggcaaggtg tgaggcgtag 4500 cggtcattgt cgacgagtgg attgctgtgc tctagagtga cgagagtcag gtcgtcggct 4560 tctgcatcaa gaaatttgat tggcttaaaa ttaaaaaggg cgtggtcaac aacttgttgt 4620 tctctataaa aaggggcggg gtgggagcct cgaggtgata gttcggcgga atctgcgacg 4680 tgcggaggcc ttgtgttctc acaagaaggt tggtatatgg ttttaaactc ggttaaaatt 4740 tccgcacaca aattgtccgt ttcaactaca tgcaaggcct taattttttg tcggcctgta 4800 caaatttctt taatggttcc tggatataat tgtgatgcaa aaacagtgct tttgttatct 4860 tgacgtgttg cgaatgaccc gtacagggca ttactcagga gttttgcaat gcttctcatg 4920 accatgtttt tttgtcggtc ggctttttct tttgctgtaa tgtttatggt tacatatttt 4980 cttacaaggc atttcatgtg cggaaacaaa gtagtcaggg cttcgggcaa gatgttaact 5040 ttccaacccc gattgtgaag tgtgataaca tcaatagtgg tggtaatttc tcctcgtagc 5100 ggttcgtttg tccagcacag tctgccccct tttcgactgc aaaaaggggg taaaacatct 5160 aattgtgttt cacacggcgg atcagcatct ataagaacta taccatgcaa caaacaagtg 5220 ttaaagtagc ttataggggc actgtttgat aagtgctttg tccagtcagc taaagcctct 5280 gcgcgggcct ttggctccag cggccaacca gaaggcattg gatgggtaag tgcggaagca 5340 tacatgccac aaatgtcata tacataaatc ggttctttca attctcccag gacggtagga 5400 taacatcgac cgccgcgtat gctttggcgt acaaaatcat acatctccct agaaggggcc 5460 agcaacacat catcaaagtt gggtttttcc ggtctgagtt cggaataaag agtctgttta 5520 aagatggcgt gggagttagc gcttattgta ggtcgctgaa aaatattgaa taggcatttg 5580 ggcagtccta ctgcattttg aataaaatga tgataagagt ctaatagttt gcagactagt 5640 ttggtggtta ctgtaacatc ttgtatgcag tattttaatg tatgttctat aaggttgtac 5700 ttgatgggac acacacgatc gggacaacgt tttcttagct cttctttttc ttttttccat 5760 tcttgtaatc cctcttcata ttcagcttcg ctgttccaat attttctgtg gggaaaacca 5820 tcaaatatat ttattgtgtc gtaccgtcca gtcatgtaaa agtcatttac ggccgcatag 5880 gggcaaacgc ctttttccag gggcaaagaa taggcctcgg cagctttacg aagagaggtg 5940 tgggtcaaag cgaatgtgtc tcgcaccatg aactttacat attgaatctt agagtcactg 6000 gtcgtgagac agccttgttc ccactgttca aagtctgttc tttttttata gcgaggattg 6060 ggcagtgaaa aagtaatgtc attaaacaga atacggccat ttcgaggcat gaagtgacgg 6120 tggactcgca ggggaggtgg aaagttcact ctgttgttta ggacttgagc cgccactaca 6180 atttcatcaa aaccattaat gttgtgacct actacataga cttcaataaa cttgggagtg 6240 ttttttaaag gcggagcttc ttgttccagt ctttcagggg ttaagtctag caatcccaaa 6300 ggaagagagt cgatgtaagt ttgtagttct ggataaatat tgttttgcca taattcctct 6360 gcaaatgctt cttggagacg atcgcgaaat cgacgaaact gtcttccaat tgcttctttt 6420 tggggattaa ttgaccacag tatgtaggga cgtaggtggt gttctgaata acccatttgt 6480 ttggcaattg agtgagcttt tgcacaaaga aacatatcac cgtagagttc cataactagc 6540 atgaagggaa ccaactgctt tccgcaactg ccatgccagc aataagtttc taggtcataa 6600 ataatgaaga gccgttttgt ggtaggtatt gaaccaagag gggtaaagct gatttttgtc 6660 caccactggc gactaagggg ttttaggttg tgaaaaaaaa aggaacgtcg tcgggcattg 6720 caggtatgtt tgaagcgaaa aaaactacca cagtcttcac atcgttgaca gggatgcatg 6780 gtatctacaa ggtacaagcc aattttgtgg tagttacttc ctttggttcc aagtcccttt 6840 tgaatatgta aaaatgtcag ttcgggtctg taattttgcc aacaccaacg cttttcttcg 6900 tatgaagcgt ctttatccac ctgtgggtag cgtccggcat ggccttttaa accaggccat 6960 ttgctttgac gaatgtacag accatcatac catacatagt ttacaggagc aggccactct 7020 tctttttgta acagtcgcgt taaagaagtt acagaaatac ttttgtgtcc aatgtctgca 7080 gctttaaaag cgtctaataa gaaaggatgc ggaaaaggac cgcatcgttg aagacataac 7140 aaattagtaa aaggtacaac ataggatgta aaatagccaa tgaccatatg atcaccgcgc 7200 ggacatgccg ctcggagggt tttgtgagct ttttgcagaa ctttactctg ttgcttctgt 7260 tttggggaac ttacagtcgc cttctttcgg ggacgtcctc gggcgggagt acgtgagctt 7320 gattgtgcat cggcatcggg cgtcgttgtt gacgaagacg agtcgcctcc tgtgatactc 7380 gacgggttaa ggtttgtatc cgttgatttc ctgtgaatac cactggaccc gaaagccgga 7440 acctgaaaga aagttccata ctgtcaatat cattgtcatt agcctcaatt tgttgtaaaa 7500 tgtctgttat atccccacta tcttcgggat ggtcgatggc gtccatgaga tgttctattt 7560 ctccttgttc aatattttga cgaccggcgt gaggaatgga agctgttagt tctctgacta 7620 accgctgcat aactgctgtc attgagtcat agcctaattc actaaaaact ctgctaaaaa 7680 caagtgttcc ttgcacgtcc ctggctcgca ggatgatttg actcagttcc aaattaagat 7740 gtctttgtgc cattagtcta tggtttaact gataatgaag ataatttagt gtggtggcta 7800 cgtgttctgt tgtaaaaaag tacatgatcc atcggtgtaa agatgcctca tttatcatat 7860 cttcgtctat tagattttct aaggtagcgt aaaaacggag tgcaaaagta aaaaagtttt 7920 gttgtcgcgc atggtcggtt agttcttctt gaagaatttc tatgctctct tgaacagcag 7980 cgcgaatagc ttgcacaaag tccaccgctt cttcctcttc atcatcctgt aagggcgaag 8040 gaggagatgg tgggggtctg ggccgtcttc tacgagtagg aatgggaagg ctttcaataa 8100 agttaacaac agcttctccg cgtcgacgca gcattgaggc ggttactgca cgaccatctt 8160 ctctaggtct tagaatagcc cctcctgcaa ggagaccggc gggtggcaag gacggggaag 8220 gagagggaag actaagacag tccatcagta acggcaaaat ctgtctcaat ggtaggtgcc 8280 ctaaaagctc cgacagatcg acttgatcat ttgagtaaaa ctcaaaccaa gaagacaacc 8340 agttttgcga atttacaggt aaggaccaaa gagtacgtgc aaaagcatct ggggggaggt 8400 cggtttcagg agccaatgtt agggcatgaa gcaaaaataa aaaatacgcc gagcggatgc 8460 gcgctatgag agacaagagc gtggcggcat tttctgcgct ctgtccctcc tcttccggag 8520 gctgtgcggg cggcggcgaa cggcaaaatt gcgcaaagcc ccaagatgac ggttggcagt 8580 gtcgcatgag gtggcgaagc ggtactggaa cggggctgtt accatctggc aatcccagtc 8640 cttccattct tgctcgatgc tgtagtccaa aatcggcaat gattcggtct gctagaatac 8700 ttcgttgtat ggctaaaaac cgttctccca tgtctgcatc ctcatcatcc acatttaaaa 8760 atcttctgta cgcacttata ttaatggtat aagaggctgt tgctaggcag agccagtcga 8820 gcagttgaat accctgccgt ctagtttcca agtacgttat tcgactgtac gttcgagtgt 8880 caaattcata atcattgaag gcgcgaacca cgtactcgta gccaacaaga aagtgaggag 8940 ggggatagga gtacaacggc cagtggcgcg tggctggggc ccgcggcgct agatctaaca 9000 gcatcagttg agggtaattg tagacaaagc gactaagcca agttacgcct ggcgcgctga 9060 cggccaccgg tggtaatgct ccgatacgat tccatatgtt tctcaggggg cggaacactt 9120 ccatcgtgta gattcgctga ccggttaggc gagcacaatc cagtggcgac tgcaaacaca 9180 caagtatatt cacgtcgcca gcgtatttag acatgcatcc tgttctgcgt caaatgctgc 9240 cctctaaaca accggggcca tctacgcctt ctgatcctgc ctggattcca cccgaagggg 9300 agggaattgc aagacaacta cctgccactg cagcagaggg aggacgggat cccgttgcct 9360 gtcatcctcg agttcagctg caacaggaca tgtctgagag ttttgtacca gcacagaacg 9420 tacttaggga agaccacagt cagggacggg gggaaccaga gggttcccga catttgcgat 9480 ttcaagccgg acaacatttg catcttaatc cggacactgt gctgagtggt aaagactttg 9540 accctagtga agaaagcatg gccgcaggcc ctgctcttag taagggtcat gcccacgtta 9600 gggcagcaga tttgctaaca gcttacgagc agacggtgcg tcaagaacaa aattttcaac 9660 aaacatttaa taatactatt cgttgtttac ttgcaagaga ggaaacaaca tggggattga 9720 tgcacctgtg ggattttgct caggctttac aaaggggacc ggaaagtcct gccttgcgcg 9780 cacaactgtt tttggtggcc cagcattgta gagacgaggg agtgtttagg gaaagtattt 9840 taaatcttgg tgcttctgaa agtagatggc tgctggactt aattaattta cttcaaagca 9900 ttgtagtgca agaaaggcgg ctagctttgg aagacaaagt cgcagcaatt aattatgctg 9960 ttcttagttt gggaaagcac tatgctagaa aaatctttcg cactgctttt gttcctgttg 10020 ataaggagct aaagataact acattctata tgaggatggt aaagaaagca ttggttctgg 10080 ctcaagaact aggggtgtat cgcaacgttc gtctgcaaag agtggtcagt gctcaaagaa 10140 aaaaggaaat gagtgatcag gagttaatgc agcagctgcg atgggccctc acagacagaa 10200 gtgaagaaga aaaaacgctg gctttaccgg ctgcggagtc ggaagacgag gaggaagggg 10260 aacgggagtg gagctcggat tttacttttt aagtgctctg tgtttttata tagagacgac 10320 ccatggctgc cttatcacct actgtcaggg cggctctgca aagccaagcg gctggggaag 10380 aaccttggga acagcgcttt aagcgtatta tgagcactac tctgaagaac cctggcgctt 10440 ttcgcagtca accgtggttt actagacgag atgcaattct ggaggctgtg ttgccttcac 10500 gtacagatcc aacgcacgaa aaggttctag cggtagttaa tggtttagtt caggcaaagg 10560 cagtaagggc ggatgaagga ggagctattt acgatgccct actgcagcgt gtgggtcgct 10620 ataacagcag taatgtacaa agcaatctag atcatttagt tcaggacgta agggaagctg 10680 tagctatgaa agctcaagag gaacgcggat ctatgggttc tttggttgcc ttgaatggtt 10740 ttttgagcac tttgcccagc acagttaatc atggtcaaag tgactatgtg gggtttgtgg 10800 gggcgctccg tcagctaatt gcagaggtac cccaaacatt agtgtataga acgggaccat 10860 tttattactt tcaaacgagt agacaaggcc ttcagacagt aaatttaaca aaagcgtttc 10920 agaacttgtc ggccctttgg ggagtaacga cttctgccca aacaccaatg gcaacagccg 10980 ctcttttaac tcccaacaca cgcctgctgc ttcttcttgt agcgcctttt acagactcgc 11040 gaacagttaa tggggacaca tacttggggc acttattaac tctttatcgt gaagcgttgc 11100 gagatgctcg cctagatgaa atcacttact ccgaaattag agatgttgca agggcaaccg 11160 gacaagatga cagtcgtgct ttacaaagca ccttaaattt tttggttagt caacaaacca 11220 aacgtcttcc agaggatgtg ttcctcaccc ctcaacagac tacggtgctg cgctacttgc 11280 aaaaagccat agagcttcag catgctcgag aaccccatga acgagccgac cgactgcttg 11340 acgcagtagt agccgatctg gagccttcat tttacagcaa gcacaggcac tttattacaa 11400 agctgttaga ttattttcag cgtgcggccg ctcttaatcc tcactacttt atgagcattg 11460 ttaaaaataa gcactggacc cctccgcctg gcttttacac tggggacttt gaacttcctg 11520 aagtggtcca cgacagtttt cagtgggatg acaccgaaga cggggcttgg agccgccctc 11580 tcgccgaaca agtcaatgaa gaagaaccca acactgacta tctggcagag tatcggagtg 11640 cgtttagtga caatagagag gaaaaaaatc aaaaaaaaga gtgggagagt cttgtggaca 11700 tgatggctcg ttggaaaact catcgtcaaa gcgccctcga tttagatgat gaaatagagg 11760 aactttcgtc cacgaatcct tttaaacatc tacagcccca attttgaagc agtgtataac 11820 ttactatttg cgccatgtgg cagcttgtag acgcagaatg agtcgctacg gaaatgctcc 11880 gcccccctac gaggaggtgg tctctgttgc gacgccttct tacgttcagc aaccgtgggt 11940 acccccgagg tactttgcgc ctacggaagg aagaaacagc atcgtttacg atcagtttcc 12000 cacttgctac gacaccacta agctcttcct cgtggacaat aaaagcgctg acattaccga 12060 tctcaacatg caaaacgacc acagccattt tgccaccacc gttgttcaaa atagcgaatt 12120 tacgccccgc gaagcaagta cccaacatat aacactggac aaccgttccc gttggggtgc 12180 taagcttaag actctgattc aaacaaactt accctcagta acagactata tgtacaccaa 12240 ctcgctgagg gttaagttga tggaatccta tgacgaagcc accggaacag ccacgtacga 12300 gtggcacgat attacccttc ccgaaggcaa cttcgacagt ggtcgaatta ttgacctgtt 12360 aaacaatgca atttgggagt tatatcttac ttacggcaga caaaatggcg tcagagaaga 12420 tcaaataggc attaagtttg atacgcgcaa ttttcgcttg ggttttgatc cgctaacaaa 12480 tcttatcatg ccgggtcatt acacctatga gtattttcac ccagacattg tgctcatgaa 12540 aggctgcgcg gtggacttta gtaaaacgcg cttaaataat gtattaggtt ggagaaagcg 12600 ctacccgtat cagcctggat ttgttatcac gtatgatgac cttgtgggag gagacatccc 12660 tcccttgtta gatttggctg cataccttaa gaagccgaga gagggagccg gaggaccaat 12720 tattagagcg ttgcaaaaag acagtaaggg tcgctcgtat cacgtccagt acactgacct 12780 gggagaagtg acggggtacc gcagcttata tcttgcgtac aattacacca gtgacgtcac 12840 acacttgcgt aagtctacag tgcgctcttg gctggttctt acggcgccgg atataacagg 12900 cggggctcaa cagttgtatt ggagtttgcc tgacatggct ttggcaccga ctacgtttcg 12960 tccgagtggt cagactcccg ccactttccc ggtggtttcc actgagccgt tgcctattgc 13020 cgccagaact atttttaacg ctcaacccgg atatgctcaa attgtaaatc aaaacactag 13080 ccaaacaatg gtctacaacc ggttccctga aaacgctatc cttatgcggc ctccccaacc 13140 gtttatggtc caagtgccag aaaatgtaac aacggtgacc gaccacggta ctcttccctt 13200 acaaaatact ttgtctggtg ttcagcgagt tgctgtaacg gatagtcgcc gccgcacttg 13260 tccttatgtg tataaatgcg ctgcaacgtt agaaccacac atcatgagca gtcgtacact 13320 gcaataaagt tgaaagcaaa gcaaacgtcg ttttttggca cgtacttttt taccctctgg 13380 tcatgtcctg tccctgtttg ttacagctga ccaataagca aatatgagta ttttgatctc 13440 gcccagcgac aacaccggtt ggggcttggg gacgggtaaa atgtacggcg gtgctcgcaa 13500 gcgctctgcc gagcatcccg ttcacgtgcg gtcttattgg cgagccgcgt ggggcagtcg 13560 aaaccggcga cgggttgcca ctgttgccgc ggaagatgct gaagcacctc agctagaaga 13620 cgtggcacaa gctcccgcaa cagtcccaat tgttaggagg cataggagaa gagtaggggg 13680 tagtgcgcgc acacgaggtc ttcgaaaaag tgcccgcgtg cgtgcagctg cgcgtgccat 13740 tgttcgagca gttaatggag cggctgcagc cgcagctcca actgtgcccg cctctgcaaa 13800 ctttgctgca atggttggtg ctatagcaaa tgcgcgggct gcatatcgcc accgccggtc 13860 tcgagcagga atcaaccccg ttcctgcgtc tcggtcaaca accagagtgc gactgccccg 13920 cactgttcgt tttcacccaa gtatgggtgc ttttcacagg cgctggtggc ggattcacac 13980 aaggggacgt agaaaggcct ctgtgcgtcg tcgtcgtact tagtctagaa cttgctattt 14040 ttaagtttat cctctcgact acatggaaga ctcccgcgtg tacttggatc gctccaatgc 14100 aactccgtcc tatatcccgg tcactccaca aattccggtg ccgggtttgg gccatagacg 14160 tgtaaaacga gaacacgtac aagtggatga agaaccaact gtgcagatac tgataaaaag 14220 accaaaagtt gaggacgagg aagttcctat tcctattttt cctcctctgc ctcctgcacg 14280 agatcccgtg gcagctgtgg cagccgcagg aggtcagatt gtaagacgca gacgccggcg 14340 ggtgcctggc actgcaatgg gagttgacac agtagacgtg gtccttccag taggagtgcg 14400 ataccatcct agtattgagg cagctaggcc accggcagtc ccgccccctc gtgcagttcc 14460 tcccgtaggg gtgcgctacc acccaagtat tgaggtagct agaccaccgg cggctcggat 14520 tagtcctcct aggcgtcgcc gccgtcgacg tagatcccct cgtcctcgcg ctacagcagc 14580 gtatcgatcg tctgcagaag tagtagaaag aagaagacgg gtggcacaaa cagtaccggt 14640 tgtacgttat cacccctcca tacaagtgga accagctgtt catcctcccc tagctcctag 14700 actccctgtt caaatggctt acacgcgcta ccatcccacc atacactaag tactcgtgcc 14760 gtcattgttg ccgtttcagc cgccatgcca gcttatggtc tgacgtatcg ctttcgtttc 14820 cccgtggcac tacgcagacg tcggaggtct cgtttcagcg ggggtagcct atatgcacga 14880 cgtaggcgac gccgagttcg tgttaaagga gggtttttgc ctgccctcat tcctctaggc 14940 gcagccttga tttcagccat accggggatc gcctcagtag ctatgcaagc aagtcaactt 15000 aaaaaataaa aagtaaagag tcatcacagg gcaaaatttt ccttttactt ctttaacttt 15060 tttagtgcca tggacgaccc attctccact ctcgcgcccc ggcggggcac acaacctcta 15120 ctaagcaact gggcaaccat tggcatcagc gagctacacg gtggagcttt ggggtggggt 15180 agttggtgga gtaacttatc tcgtttgggc agtagcttcg gcagcaattt aaaaaacttg 15240 ggtctaaaag cttggaacag tagtacagga caagcactgc gtcagcatct taaagatacc 15300 aatttacaac acaaggtggt agaggggctt tcaacaggca ttcacggggc agtagacata 15360 gctcggcagg aagtggacag acagttggcc aagcgactgg aaaactacga accaccgcga 15420 gtggcgtcca ccgaagaaac agtggatgat gtaaaaaccg tggctttgcc ctccaaagaa 15480 gacgagtccg aaagagtact ggtgacaaag attcgtgagc ctccaccgcc ttacgatgct 15540 gtgtttggtc ccgcgccatc tgcggaaact aataagaagc aaaagttcga ggaaaccctg 15600 caaaatgccg gtctggtttc ttctccaccg gcccccatag ccgcgcccgc agccatagcc 15660 gttcccgcac aaacaacgat gtcgcacccg gcgtctagcc gtcgccggca tcattggcaa 15720 ggaactctgg acagcataat gggcctgggt ttacaaccta tcaaacgccg gcgctgtttt 15780 taaatgttct aagttgctta ctttttgtta gcggacacaa gatcattcgt attgctcgca 15840 cttcactagg actctgagcg gtgtccgcca tgacgacgcc ttcaatgcag ccccagtggg 15900 ccttcatgca catcgcggga caggacgctt cccaatacct gtcaccaggg gtggtgcagt 15960 ttgcagcggc cacagatacg tacttttctc tcggaaacaa gtttcgcaat ccaactgtgg 16020 cccccaccca tgacgttacg acagaccggt ctcaaagact cacactgcgt atagtcccgg 16080 tggacagaga agacagccag tacacctaca aaaccaggtt tcaactttct gttggggata 16140 accgagttct ggacatggcc agcacttact ttgacattcg cggccgcctc gacagaggcc 16200 ccagctttaa accctactca ggaacggcgt ataacagcct ggcgccgcga gctgctccga 16260 ataatttaat gtttaaaaca ggagcagaca gcaaaactat gaccatagct caggccaaca 16320 ttgtcggctc gaccatagat caagacggtt taaaaataaa caacgtagcc ctgaacccga 16380 atgctggtga gccggcagtg caggaaggtt tggaaaattg gatggaagaa ttacaaattg 16440 gtgctgacaa aaaatttgcc agccgcgttc ttaaagccga ccaacctgtg ctgcccaact 16500 acggaagtta tgcttatccc acaaacatca acggcaccca aacaaaagac ggcaccacag 16560 tagacaaagt gtacatgtgc tccaaaggag caaatgtaca aaacccagac gtcgtgctgt 16620 acagcgaaga ggtgaatttg caagctccgg acacacatct gctagatggt cccggtgctg 16680 acaaccccaa agacagagtg gctttttgcg ctgctcccaa ccgaccaaat tacatcggtt 16740 ttagagataa ttttatcggc ctgatgtact ataatagcaa tggcaaccag ggagtgttgg 16800 cgggacaggc ttcacagctc aatgctgttg tagatttaca ggacagaaat actgagctga 16860 gttaccagtt tcttttggat tcgctctatg accggagtcg gtacttttca ttgtggaacc 16920 aagcaataga tagctacgat ccccgggtac gcattattga aaatgacggt gtagaggacg 16980 acatcacctc ttttgctttt gaccttcggg gaataggcga tctaccgtac aaacaggtgc 17040 aaactcacaa tggaaaccaa cagtcggcca acactaccga cacttgttac attggaaagg 17100 gaaacatggc tgccatggag ataaacattc cagccaactt atggctcggc tttttgtacg 17160 ccaatgtggc tcagtatatg ccggacgact ttaaagtgga cccgtcgaac attcaaatgc 17220 cacaggacaa aaccacgtac gcttacatga accaaagaat tgctcctgcc gggcttatag 17280 aaacctacgt aaacgtaggc gggcgttggt cagttgactt catggacacg gtcaatccct 17340 tcaatcatca ccgaaatgaa gggctaaagt accggtccca gatattagga aatgggcggt 17400 ttgtagactt tcacattcaa gtgcctcaaa aattttttgc tatcaaaagt ttgcttttgc 17460 tccccggcag ttacacctat gagtggagct ttcgcaaaga cgtaaacatg gtcttgcaaa 17520 gctccttagg taatgatctc agagctgacg gcgcaaggct cgagattcac agtgtgaatc 17580 tttacgccag ttttttcccc atggcgcaca atacagcatc aactcttgaa gcgatgctgc 17640 gtaatgaaac aaatgaccag acttttttgg actacctgag cagcgcaacg atgatgtttc 17700 ccattcctgc aggtcaaacc caagtgccag tatcaattcc agccagaaac tgggcagcct 17760 ttaggggttg gagctttact cgtattaaac aacaagaaac gcccaacata ggctcaccgt 17820 atgacccgta ctttaagtac agcggaagca tacctttctt ggatgctact ttttacctaa 17880 cacacacctt tcagcgagtt tcaattatgt ttgactcttc agtaagttgg ccaggaaacg 17940 accgacttct aactccaaac gagtttgaaa taaaacgtca cattgacgct gaaggactat 18000 gtgtgggtca aagtaacatg actaaggact ggtttttggt gcaaatgctg tccaactaca 18060 acatcggata tcagggcttt tatttaccag aaaacaacaa agacagaaca tactcttttg 18120 ttcgaaactt tgaacccctg gcccggcaag tggtggatga tgctgctgcg gctaactatc 18180 gagacgttcc tctttccaaa agatttaaca attcgggttg gagaagcgcc ggtcctccaa 18240 tatttgctcg agagggggcg ccttatcctg ctaactggcc ctatccactg tgtggagagg 18300 cggcatgggc tgcaaaaacc caaagaaaat ttctagttga ccggtacatg taccgcattc 18360 ccttttctag caactttatg tcaatgggcg ctttaacgga cctgggacag aatttgctat 18420 acgcaaattc cgcccattct ttggaaatga cttttaatgt ggaccccatg caagaagcca 18480 cttttctgta cattttgttt gaagtctttg actgtgttcg catccaccaa ccgcacaggg 18540 gcatcataga ggcagtgtac ctgcgctccc cgttttcagc cggcaacgca accacctaat 18600 cgtatgggtt cgtctgaaac agagctccgt caactggtcg ctgaccttgg aataggttct 18660 tttttaggta tttttgataa acacttcccc ggctttataa gtgttaacaa accggcttgt 18720 gctatcgtta atacagcaag tcgagaaact ggaggggtac actggctagc tatggcttgg 18780 tatcctacct cttccacttt ttacttgttt gatccgtttg gattttcgga tcgtaaactg 18840 caacaagtgt ataagttcga gtacgaacgg cttctcaaac gatcagctgt tagcagctct 18900 agcagcaagt gtgtaacact agtaaaaagc caccaaaccg tccaggggcc tcatagcgca 18960 gcgtgtggac tcttttgtgt tctattttta gcagctttcg gaaagtatcc acaaaacccc 19020 atgaacaata acccaatcat gggaccgatt gagggagttc ctaacgatca aatgtttaat 19080 ccctgctata ctaaaacctt gtaccgtaat caacaatggg tatattctta cttaaataag 19140 aactcgcttt attttaggct acatgtagaa cttattaaaa aaaatacagc gtttgacaaa 19200 ttgttagtgc gcaaatgact ttattgtaat tgttggtata ttgtaagtat tggcattcac 19260 aatcattaaa gggaaagcaa aatcgttttg ttgccttgac ctcgtactta aactttcgcc 19320 gttacaaaaa gttgaacatc gccatctccg gcaccttggg gcagcacagt ggagtggaaa 19380 cacaatgttg gatcccactt aaattcaggc acaaaaaggg aagggggttg atccaagagt 19440 ttttggatca tttttttagc gagttgcgcc gccgtcacca catccacaga gctgattttc 19500 cactcacagc tttttccaac ggtgcctttt ccagccttac caaaggtaac attgcagcac 19560 tggtacacaa gtaccacggg attctcaaca ctagcccttg caacgggatc tagagcggta 19620 gcatccagcc cttcagccaa agataaagca tagggagtca cgcggcatgt ttggcgaccc 19680 aaaataggtt gagccaaacc aaagttacac tcacaacgga ggcacagcaa cattctttct 19740 cccacccccg gggcttgggg atacagtgcc tgttgaaagg caattgcttg cttaaaaccc 19800 tttagtgcct ttttggcatc ggtaaaacaa aaaccacacg acttattggt tggttgatta 19860 aaggctacag aagcatccat ggcacacaca actgcgtcat aggttacacg caccactgaa 19920 cgaccccagc gattagtttg aacacaagca gcgctccctt gttccttcaa agccctctgc 19980 ccaccctccg tagtcacatc taactcaact tgatgatcct tgggagacat agcagtgccg 20040 tgtaaacagt gaagcgtagt agaacagttg tgcttccacg ccgccacacc ggtaacatta 20100 cccaaggtat gggcagcaaa atccacaggc gaaatgcctg ccgcttgcag aagcatggca 20160 aaaacaaaac gccccatttg catggtaaag gaacgcaacg tggaaaaggt taaactagga 20220 actaattttt gttgcaaaag ccagctatgg ctcagcttcc taaatagctc agcggtttga 20280 gcattgggca agaaggtaca ctgcttgcca tcaactttta acaccaaaca catcttgtgc 20340 aatagctctc tagctgtttg ccaacacgct tcctcttctt ctgcgacgcc tgcttcagta 20400 aacaccacgt cgtcctcatc cgaggattca aatcgtggag ggacctccgt ctggggctca 20460 ggttccatgt tcacatcttc actgcctctg tcgccaccgg aaacatttgc aaatttccct 20520 gaaacagcag gagcaagcgg ggaactgcgc gggccaagag cagctcggct ctttttaccg 20580 cagtgggccg tagacgcctc gccaacagca gagcgcttaa ccccgccacg cttggtttca 20640 taaacctgct gttgaggggt gcgctgtggt ggtacaggtc gcgagcagct catcgtcctc 20700 gtctgattct ttgctctaca gaatacaaaa gcaatgcagt caaacaccca ggaaagtgag 20760 acaaccgagg tgccagatac aaatccaact ccgttagagg aagaaacaag caaaagcgac 20820 acacatgaag cgacaaacga cagcaactac ttgtccgcgg actcgcttct tgttcacatc 20880 cagcgccaag cgcgtatcct acgcgaggcc ctacagcccg agcaagacaa aacagaatgg 20940 tctgccacaa ccctgtctca tatgctggaa agagagctgt ttacccgctc caacgcaaaa 21000 tttcccgcag ttcccaagca aagcaatggc tcaatgagcc cagaccctcg tctcaatttt 21060 tatccggcat ttatggtgcc cgaggctctg gctacctatc accctttttt cgtaaatcag 21120 cggattcctc taagttgcag agctaaccgc cccttggcag acaagaattg ggagctgaaa 21180 gatggaagca ggctgcccga cattgttacc gtgcaagaac aaccgcgatt tttcgaaagc 21240 ctgcaaggcc aggaattgag ccgaaaccaa cttgaagtgg caggcagcga cagcgagacc 21300 ggggttttaa ctgaactgga gggggacagc ccccgccttg ctgtggtaaa gcgctgcctg 21360 agtgtgacgc atgctgccta tcccgccctc ggtttgccgc caaaagtttc caaaattatg 21420 tcagaggaat tgaccttcaa aacaaattta gaaactggag acaacagtca accggtggtc 21480 agcgacgaac aattacaaaa atggctcaag gccaaagatc ctgccgatcc cgccatagag 21540 gaacatcgca aacgggtcat ggccgtgacc ttaattacgt gccagctgga agcactgcgt 21600 tctttttttt cgcgcgcaga tgttatccgc cgtgtagggg aaagtctcca ctacttgttc 21660 caacacggtt acgtcaaaca agccatacaa gtgtgccaaa ccgatttaac gcatttggtc 21720 acgtacatgg gaattgtgca tgagaacaga ctaggccaaa cagtcctaca cgggtcattg 21780 ctgggggaag cgcgaagaga ctatatacgg gatactgttt atttgttcct aatttatact 21840 tggcaaacgg ccatgggtgt atggcaacag tgcttagaag acgaaaattt agaaaagctc 21900 agaaaaatct tgcagtctca tcgccgctct ctgtacacag aaacaaatga gcgccttctt 21960 gccgctgaac tgcgccgtct ggtgtttcct gcccacctgg aaaatacttt ggcgcaaggt 22020 cttccagaca tcttgcacca gagcattatt aacaattttc gttcgtttat tttagaacgt 22080 agtggtattt tgccggccac cacatgtgcc tacccttccg attttgttcc cactacattc 22140 aaagagtgtc ctcctccttt atgggctcac acttatttgc ttactttagc aaactatttc 22200 atgtatcaca acgacttgca agaagaccta acaggcgcgg gactgttgag cgctcactgc 22260 cgctgcaact tgtgcagtcc ccaccgcagc ctggtccaca acactgcttt actcaatgaa 22320 gtaaaatgca ttaatacctt tgagttgcag ggacctcctg gaaaagacgg taaaagtggg 22380 ccctgtttta aattaacacc tggcttgtgg gtgtctgcct acttacgtaa gtttgaggaa 22440 caggattacc atccttatag tattacctac tttgaaaatt caaaaaagca acagcctaag 22500 acccctctta gcgcatgtgt tcttacgcag acagaactgg ttgcacagct gttggctatt 22560 aacgaccatc ggcgggaatt tctacatcaa aagggaaggg gagtgtacct agatcctcag 22620 actggcgaag aaatcggcaa gggcagtgct gaccctgctt ccctctcaga ctcagacagc 22680 catgcagaag acagggaagg acagccaact gcgggtgcag gaagacgagg gagagtggag 22740 cgcggacggg tacagcgcag acagcgacag cgtccaggag gacacttcat ccgaggagga 22800 cgaagttccc cagacggctg cagcgctcca gcccgagagc gaaacaggga aaacgagccc 22860 cccgccctcg aatgcgactg ccaccaccac caccatcaca aagaggaaga aaaagaaagt 22920 acccattcga tgggactttc ctccagcaca gaacacattg ggtaagcctg ttgcggttcg 22980 cagcagcgat ggcagcgcaa ctaaactcac agaagtgaat gataggaaca catggaaacc 23040 ttacaaaggc gccatattaa aagctttatt tgcctacgga ggggaccgag gggcggtgcg 23100 gagattttta cttttcaacc gaggaacatt agtacccaga agagtaatta gctattactg 23160 tcgtcgctac tacagccgcc gagaggcttt gtgacactgc accgccaacc aaaaaacgcc 23220 gccgacgtct gtctactcca gcagcatccg atcctctaca agcgctacgc gacgacatct 23280 ttgttactat ttatgcaaca tttcaacgtg ttcgggcact gggtctcgac acatactctc 23340 ttaaagttag aaaccgtact ttacgttccc taaccagaag ctgtctatat caccaacaag 23400 agtcccagct ggaacgcacc aagagggacg ccgaagctct gctatctaag cactgccgca 23460 cattatcaag caattgaact ttcaatgtca gctccttctc cctatgtgtg gacttttcag 23520 cctcagcggg gtaccgctgc aggagcttct caagactaca gtacgcgcat aaactggctt 23580 agtgccggcc ccgagcttag aggaaaagtc gtacaactca atgaggcaag aaacgctatt 23640 ctgatgaagg aacaagagtc cgtgcccacc cctcgagccg aagccaatcc ttccttttgg 23700 cctgcggcgc ttattttcca accacgcccc caagctattc ctgtacatcc tgcccatccc 23760 gacacctttg acgccgccct aacaagcaac ggagcgcaat tagctggagg ggcgtggata 23820 aactataaaa acggtagtgt tcgctacgaa gcgcccttgc agctggccga ggaacaggtc 23880 ggtggaccgc taaacgcctt tgctataaaa catcagctac aactagcagg aggagctctt 23940 tctgcttcta tgtccgaaat gagcggggcg cccagaatcc cgcgcagcgg aggtattggg 24000 tcgtggcaat tttctcgaga attcccccct actgtttacc ttaacccttt ttccggcagt 24060 cctgacactt ttcctcatca atttctttct aactatgact ctttctctca cacggtggac 24120 gggtatgact gattcaccgt ccagatcggc tgcgcttcct gtgcctgctt ctactcgtat 24180 tgggttggtg tttatgttaa gtggagaggc agagcaactg cgcctgaaac acctggtcca 24240 ctgtcgccgc cacaagtgct ttgcccgcga ctccggtgag ttttgctact ttgaattgcc 24300 cgaggatcat atcgagggcc cggcgcacgg cgtccggctt accgcccagg gagagcttgc 24360 ccgtagcctg attcgggagt ttacccagcg ccccctgcta gttgagcggg acaggggacc 24420 ctgtgttctc actgtgattt gcaactgtcc taaccctgga ttacatcaag atctttgttg 24480 ccatctctgt gctgagtata ataaatacag aaattaaaat atactggggc tcctatcgcc 24540 atcctgtaaa cgccaccgtc ttcacccgcc caagcaaacc aaggcgaacc ttacctggta 24600 cttttaacat ctctccctct gtgatttaca acagtttcaa cccagacgga gtgagtctac 24660 gagagaacct ctccgagctc agctactcca tcagaaaaaa caccaccctc cttacctgcc 24720 gggaacgtac gagtgcgtca ccggccgctg caccacacct accgcctgac cgtaaaccag 24780 actttttccg gacagacctc aataactctg tttaccagaa caggaggtga gcttagaaaa 24840 cccttagggt attaggccaa aggcgcagct actgtggggt ttatgaacaa ttcaagcaac 24900 tctacgggct attctaattc aggtttctct agaatcgggg ttggggttat tctctgtctt 24960 gtgattctct ttattcttat actaacgctt ctctgcctaa ggctcgccgc ctgctgtgtg 25020 cacatttgca tttattgtca gctttttaaa cgctggggtc gccacccaag atgattaggt 25080 acataatcct aggtttactc acccttgcgt cagcccacgg taccacccaa aaggtggatt 25140 ttaaggagcc agcctgtaat gttacattcg cagctgaagc taatgagtgc accactctta 25200 taaaatgcac cacagaacat gaaaagctgc ttattcgcca caaaaacaaa attggcaagt 25260 atgctgttta tgctatttgg cagccaggtg acactacaga gtataatgtt acagttttcc 25320 agggtaaaag tcataaaact tttatgtata cttttccatt ttatgaaatg tgcgacatta 25380 ccatgtacat gagcaaacag tataagttgt ggcccccaca aaattgtgtg gaaaacactg 25440 gcactttctg ctgcactgct atgctaatta cagtgctcgc tttggtctgt accctactct 25500 atattaaata caaaagcaga cgcagcttta ttgaggaaaa gaaaatgcct taatttacta 25560 agttacaaag ctaatgtcac cactaactgc tttactcgct gcttgcaaaa caaattcaaa 25620 aagttagcat tataattaga ataggattta aaccccccgg tcatttcctg ctcaatacca 25680 ttcccctgaa caattgactc tatgtgggat atgctccagc gctacaacct tgaagtcagg 25740 cttcctggat gtcagcatct gactttggcc agcacctgtc ccgcggattt gttccagtcc 25800 aactacagcg acccacccta acagagatga ccaacacaac caacgcggcc gccgctaccg 25860 gacttacatc taccacaaat acaccccaag tttctgcctt tgtcaataac tgggataact 25920 tgggcatgtg gtggttctcc atagcgctta tgtttgtatg ccttattatt atgtggctca 25980 tctgctgcct aaagcgcaaa cgcgcccgac cacccatcta tagtcccatc attgtgctac 26040 acccaaacaa tgatggaatc catagattgg acggactgaa acacatgttc ttttctctta 26100 cagtatgatt aaatgagaca tgattcctcg agtttttata ttactgaccc ttgttgcgct 26160 tttttgtgcg tgctccacat tggctgcggt ttctcacatc gaagtagact gcattccagc 26220 cttcacagtc tatttgcttt acggatttgt caccctcacg ctcatctgca gcctcatcac 26280 tgtggtcatc gcctttatcc agtgcattga ctgggtctgt gtgcgctttg catatctcag 26340 acaccatccc cagtacaggg acaggactat agctgagctt cttagaattc tttaattatg 26400 aaatttactg tgacttttct gctgattatt tgcaccctat ctgcgttttg ttccccgacc 26460 tccaagcctc aaagacatat atcatgcaga ttcactcgta tatggaatat tccaagttgc 26520 tacaatgaaa aaagcgatct ttccgaagcc tggttatatg caatcatctc tgttatggtg 26580 ttctgcagta ccatcttagc cctagctata tatccctacc ttgacattgg ctggaacgca 26640 atagatgcca tgaaccaccc aactttcccc gcgcccgcta tgcttccact gcaacaagtt 26700 gttgccggcg gctttgtccc agccaatcag cctcgcccac cttctcccac ccccactgaa 26760 atcagctact ttaatctaac aggaggagat gactgacacc ctagatctag aaatggacgg 26820 aattattaca gagcagcgcc tgctagaaag acgcagggca gcggccgagc aacagcgcat 26880 gaatcaagag ctccaagaca tggttaactt gcaccagtgc aaaaggggta tcttttgtct 26940 ggtaaagcag gccaaagtca cctacgacag taataccacc ggacaccgcc ttagctacaa 27000 gttgccaacc aagcgtcaga aattggtggt catggtggga gaaaagccca ttaccataac 27060 tcagcactcg gtagaaaccg aaggctgcat tcactcacct tgtcaaggac ctgaggatct 27120 ctgcaccctt attaagaccc tgtgcggtct caaagatctt attcccttta actaataaaa 27180 aaaaataata aagcttaaaa tttgcaacac gtactccggc tcgcctccta tgttttcttt 27240 gcagaaggac aagaaaaaca tggtagaggc gctaaatgct gtctatccct atgacttggc 27300 tttactcccc gaagactatg aaaagaccac cgcgcccgac gccgtccaag ccgcgaatgc 27360 cgcccgcccg tttctaaatc ccgtctaccc ttaccaacaa cctgtagccg gagactttgg 27420 ttttcccatt gtaatgcctc ccttttttaa tagttacgat tttactagca tacatggtaa 27480 tacactgtct ctgcggctca acaagcccct aaaaagaaca gcaaaaggct tacaactttt 27540 actaggcagt ggactaagtg ttaatgcaga cggacagtta gagagctctg agggtataag 27600 cgaggccgat gctcccttac aaattaacga cggagttctt cagctatcct ttggggaagg 27660 tttaagcgtg aacgaccacg gtgaactgga aagcaaaggg aaagtggaag cagtcactct 27720 tccactggcc ttacaagatc atgtaatgag cctgtctttt ggtcaaggtt tgcaagtaaa 27780 cgaccaaggt cagctggagg cgctagcaat ggttcacagc acttccgcgc ccttgaaagt 27840 tacaaacaac aatctagaat tagccctcgg acgaggtctc atagtagatg accaaggtca 27900 gctaaggtta gccccaaatc tactgtggcc agaaagtccc ctcgccattg aacagggaac 27960 taaccatcta attctttttt acaaccaaag tctggatgtg gaagatggca aactcaccct 28020 gcccgaacct tttgaccctc taactttaga cgggggaaga ctgcgaatgc agctagctcc 28080 taacagcggg cttgctgtga ctgaaaaagg cagcttagga attaattggg gtgagggaat 28140 acaagtaaaa gaacaaaaaa taacactaaa agtaacccct gccaacggtc ttgctgtaac 28200 cgagcaaggt ggcttaaaca taaactgggg caatggaatc aaagtggatg aacaaaaggt 28260 aacactaaaa actagcaatg aatttgcttt gaccgaaaat gggttatacc taactagtcc 28320 tctgaaccca atcgaagtta accaacatgg acaattgggc atagccctag gctatggttt 28380 tcatgctcac aggggctact tagaattaac tccccaaaca ctgtggacag gccttcccat 28440 tgggaataat ggcacttttc acaccaaaca agactgcaaa atttttttaa gtctgactcg 28500 cttggggccc atggttcacg gaacatttat gctgcaagct ccacagtatg aactaacaac 28560 caacggcatg agagaaatta cttttagttt taactccact ggaggactag aacaacccgc 28620 tcccgtaaca tactggggtg ccctagatcc tccccccaca gctaaagcag ctgaaataga 28680 aaaccagaag cgcgtgaaaa aacgcgctgc tcccgatccc cccgtagaac caccgcccaa 28740 acgacgagga gatctagcag ttctctttgc aaaagttgca gagcaggcaa tggagcttgc 28800 caaagagcag gcagttcagg cccaaccccc agaacatgtt aacactgatt gggccgacca 28860 catgaacctg ctgcgtttca tgcccaatac cttggtgtac cccaccgcgg ccacaattgc 28920 tgctaatctt caattccatg atacccgcct aagtcttaga agggcaaccc tcaaaataag 28980 actgaatggc agtccagact ctgcctacca actggggttt atgctggaat tggttggaac 29040 ccaatctgca tctattgtta ctgacactat aagtttttgg tactatgctg aagactatta 29100 ataaagaatc gtttgtgtta tgtttcaacg tgtttatttt tcaattgcag aaaatttcga 29160 atcatttttc attcagtagt atagccccac caccacatag cttatacaga tcaccgtacc 29220 ttaatcaaac tcacagaacc ctagtattca acctgccacc tccctcccaa cacacagagt 29280 acacagtcct ttctccccgg ctggccttaa aaagcatcat atcatgggta acagacatat 29340 tcttaggtgt tatattccac acggtttcct gtcgagccaa acgctcatca gtgatattaa 29400 taaactcccc gggcagctca cttaagttca tgtcgctgtc cagctgctga gccacaggct 29460 gctgtccaac ttgcggttgc ttaacgggcg gcgaaggaga agtccacgcc tacatggggg 29520 tagagtcata atcgtgcatc aggatagggc ggtggtgctg cagcagcgcg cgaataaact 29580 gctgccgccg ccgctccgtc ctgcaggaat acaacatggc agtggtctcc tcagcgatga 29640 ttcgcaccgc ccgcagcata aggcgccttg tcctccgggc acagcagcgc accctgatct 29700 cacttaaatc agcacagtaa ctgcagcaca gcaccacaat attgttcaaa atcccacagt 29760 gcaaggcgct gtatccaaag ctcatggcgg ggaccacaga acccacgtgg ccatcatacc 29820 acaagcgcag gtagattaag tggcgacccc tcataaacac gctggacata aacattacct 29880 cttttggcat gttgtaattc accacctccc ggtaccatat aaacctctga ttaaacatgg 29940 cgccatccac caccatccta aaccagctgg ccaaaacctg cccgccggct atacactgca 30000 gggaaccggg actggaacaa tgacagtgga gagcccagga ctcgtaacca tggatcatca 30060 tgctcgtcat gatatcaatg ttggcacaac acaggcacac gtgcatacac ttcctcagga 30120 ttacaagctc ctcccgcgtt agaaccatat cccagggaac aacccattcc tgaatcagcg 30180 taaatcccac actgcaggga agacctcgca cgtaactcac gttgtgcatt gtcaaagtgt 30240 tacattcggg cagcagcgga tgatcctcca gtatggtagc gcgggtttct gtctcaaaag 30300 gaggtagacg atccctactg tacggagtgc gccgagacaa ccgagatcgt gttggtcgta 30360 gtgtcatgcc aaatggaacg ccggacgtag tcatatttcc tgaagcaaaa ccaggtgcgg 30420 gcgtgacaaa cagatctgcg tctccggtct cgccgcttag atcgctctgt gtagtagttg 30480 tagtatatcc actctctcaa agcatccagg cgccccctgg cttcgggttc tatgtaaact 30540 ccttcatgcg ccgctgccct gataacatcc accaccgcag aataagccac acccagccaa 30600 cctacacatt cgttctgcga gtcacacacg ggaggagcgg gaagagctgg aagaaccatg 30660 tttttttttt tattccaaaa gattatccaa aacctcaaaa tgaagatcta ttaagtgaac 30720 gcgctcccct ccggtggcgt ggtcaaactc tacagccaaa gaacagataa tggcatttgt 30780 aagatgttgc acaatggctt ccaaaaggca aacggccctc acgtccaagt ggacgtaaag 30840 gctaaaccct tcagggtgaa tctcctctat aaacattcca gcaccttcaa ccatgcccaa 30900 ataattctca tctcgccacc ttctcaatat atctctaagc aaatcccgaa tattaagtcc 30960 ggccattgta aaaatctgct ccagagcgcc ctccaccttc agcctcaagc agcgaatcat 31020 gattgcaaaa attcaggttc ctcacagacc tgtataagat tcaaaagcgg aacattaaca 31080 aaaataccgc gatcccgtag gtcccttcgc agggccagct gaacataatc gtgcaggtct 31140 gcacggacca gcgcggccac ttccccgcca ggaaccatga caaaagaacc cacactgatt 31200 atgacacgca tactcggagc tatgctaacc agcgtagccc cgatgtaagc ttgttgcatg 31260 ggcggcgata taaaatgcaa ggtgctgctc aaaaaatcag gcaaagcctc gcgcaaaaaa 31320 gaaagcacat cgtagtcatg ctcatgcaga taaaggcagg taagctccgg aaccaccaca 31380 gaaaaagaca ccatttttct ctcaaacatg tctgcgggtt tctgcataaa cacaaaataa 31440 aataacaaaa aaacatttaa acattagaag cctgtcttac aacaggaaaa acaaccctta 31500 taagcataag acggactacg gccatgccgg cgtgaccgta aaaaaactgg tcaccgtgat 31560 taaaaagcac caccgacagc tcctcggtca tgtccggagt cataatgtaa gactcggtaa 31620 acacatcagg ttgattcaca tcggtcagtg ctaaaaagcg accgaaatag cccgggggaa 31680 tacatacccg caggcgtaga gacaacatta cagcccccat aggaggtata acaaaattaa 31740 taggagagaa aaacacataa acacctgaaa aaccctcctg cctaggcaaa atagcaccct 31800 cccgctccag aacaacatac agcgcttcca cagcggcagc cataacagtc agccttacca 31860 gtaaaaaaga aaacctatta aaaaaacacc actcgacacg gcaccagctc aatcagtcac 31920 agtgtaaaaa agggccaagt gcagagcgag tatatatagg actaaaaaat gacgtaacgg 31980 ttaaagtcca caaaaaacac ccagaaaacc gcacgcgaac ctacgcccag aaacgaaagc 32040 caaaaaaccc acaacttcct caaatcgtca cttccgtttt cccacgttac gtcacttccc 32100 attttaagaa aactacaatt cccaacacat acaagttact ccgccctaaa acctacgtca 32160 cccgccccgt tcccacgccc cgcgccacgt cacaaactcc accccctcat tatcatattg 32220 gcttcaatcc aaaataaggt atattattga tgatgtaggg ataacagggt aat 32273 <210> 80 <211> 34760 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO254) <400> 80 cctatctaat aatatacctt atactggact agtgccaata ttaaaatgaa gtgggcgtag 60 tgtgtaattt gattgggtgg aggtgtggct ttggcgtgct tgtaagtttg ggcggatgag 120 gaagtggggc gcggcgtggg agccgggcgc gccggatgtg acgttttaga cgccatttta 180 cacggaaatg atgttttttg ggcgttgttt gtgcaaattt tgtgttttag gcgcgaaaac 240 tgaaatgcgg aagtgaaaat tgatgacggc aattttatta taggcgcgga atatttaccg 300 agggcagagt gaactctgag cctctacgtg tgggtttcga tacgtgagcg acggggaaac 360 tccacgttgg cgctcaaagg gcgcgtttat tgtttgtttt tctcaggtgt tttccgcgtt 420 ccgggtcaaa gttggcgttt tattattata gtcagctgac gtgtagtgta tttatacccg 480 gtgagttcct caagaggcca ctcttgagtg ccagcgagta gagttttctc ctccgagccg 540 ctccgacacc gggactgaaa atgagacata ttatctgcca cggaggtgtt attaccgaag 600 aaatggccgc cagtcttttg gaccagctga tcgaagaggt actggctgat aatcttccac 660 ctcctagcca ttttgaacca cctacccttc acgaactgta tgatttagac gtgacggccc 720 ccgaagatcc caacgaggag gcggtttcgc agatttttcc cgactctgta atgttggcgg 780 tgcaggaagg gattgactta ctcacttttc cgccggcgcc cggttctccg gagccgcctc 840 acctttcccg gcagcccgag cagccggagc agagagcctt gggtccggtt tctatgccaa 900 accttgtacc ggaggtgatc gatcttacct gccacgaggc tggctttcca cccagtgacg 960 acgaggatga agagggtgag gagtttgtgt tagattatgt ggagcacccc gggcacggtt 1020 gcaggtcttg tcattatcac cggaggaata cgggggaccc agatattatg tgttcgcttt 1080 gctatatgag gacctgtggc atgtttgtct acagtaagtg aaaattatgg gcagtgggtg 1140 atagagtggt gggtttggtg tggtaatttt ttttttaatt tttacagttt tgtggtttaa 1200 agaattttgt attgtgattt ttttaaaagg tcctgtgtct gaacctgagc ctgagcccga 1260 gccagaaccg gagcctgcaa gacctacccg ccgtcctaaa atggcgcctg ctatcctgag 1320 acgcccgaca tcacctgtgt ctagagaatg caatagtagt acggatagct gtgactccgg 1380 tccttctaac acacctcctg agatacaccc ggtggtcccg ctgtgcccca ttaaaccagt 1440 tgccgtgaga gttggtgggc gtcgccaggc tgtggaatgt atcgaggact tgcttaacga 1500 gcctgggcaa cctttggact tgagctgtaa acgccccagg ccataaggtg taaacctgtg 1560 attgcgtgtg tggttaacgc ctttgtttgc tgaatgagtt gatgtaagtt taataaaggg 1620 tgagataatg tttaacttgc atggcgtgtt aaatggggcg gggcttaaag ggtatataat 1680 gcgccgtggg ctaatcttgg ttacatctga cctcatggag gcttgggagt gtttggaaga 1740 tttttctgct gtgcgtaact tgctggaaca gagctctaac agtacctctt ggttttggag 1800 gtttctgtgg ggctcatccc aggcaaagtt agtctgcaga attaaggagg attacaagtg 1860 ggaatttgaa gagcttttga aatcctgtgg tgagctgttt gattctttga atctgggtca 1920 ccaggcgctt ttccaagaga aggtcatcaa gactttggat ttttccacac cggggcgcgc 1980 tgcggctgct gttgcttttt tgagttttat aaaggataaa tggagcgaag aaacccatct 2040 gagcgggggg tacctgctgg attttctggc catgcatctg tggagagcgg ttgtgagaca 2100 caagaatcgc ctgctactgt tgtcttccgt ccgcccggcg ataataccga cggaggagca 2160 gcagcagcag caggaggaag ccaggcggcg gcggcaggag cagagcccat ggaacccgag 2220 agccggcctg gaccctcggg aatgaatgtt gtacaggtgg ctgaactgta tccagaactg 2280 agacgcattt tgacaattac agaggatggg caggggctaa agggggtaaa gagggagcgg 2340 ggggcttgtg aggctacaga ggaggctagg aatctagctt ttagcttaat gaccagacac 2400 cgtcctgagt gtattacttt tcaacagatc aaggataatt gcgctaatga gcttgatctg 2460 ctggcgcaga agtattccat agagcagctg accacttact ggctgcagcc aggggatgat 2520 tttgaggagg ctattagggt atatgcaaag gtggcactta ggccagattg caagtacaag 2580 atcagcaaac ttgtaaatat caggaattgt tgctacattt ctgggaacgg ggccgaggtg 2640 gagatagata cggaggatag ggtggccttt agatgtagca tgataaatat gtggccgggg 2700 gtgcttggca tggacggggt ggttattatg aatgtaaggt ttactggccc caattttagc 2760 ggtacggttt tcctggccaa taccaacctt atcctacacg gtgtaagctt ctatgggttt 2820 aacaatacct gtgtggaagc ctggaccgat gtaagggttc ggggctgtgc cttttactgc 2880 tgctggaagg gggtggtgtg tcgccccaaa agcagggctt caattaagaa atgcctcttt 2940 gaaaggtgta ccttgggtat cctgtctgag ggtaactcca gggtgcgcca caatgtggcc 3000 tccgactgtg gttgcttcat gctagtgaaa agcgtggctg tgattaagca taacatggta 3060 tgtggcaact gcgaggacag ggcctctcag atgctgacct gctcggacgg caactgtcac 3120 ctgctgaaga ccattcacgt agccagccac tctcgcaagg cctggccagt gtttgagcat 3180 aacatactga cccgctgttc cttgcatttg ggtaacagga ggggggtgtt cctaccttac 3240 caatgcaatt tgagtcacac taagatattg cttgagcccg agagcatgtc caaggtgaac 3300 ctgaacgggg tgtttgacat gaccatgaag atctggaagg tgctgaggta cgatgagacc 3360 cgcaccaggt gcagaccctg cgagtgtggc ggtaaacata ttaggaacca gcctgtgatg 3420 ctggatgtga ccgaggagct gaggcccgat cacttggtgc tggcctgcac ccgcgctgag 3480 tttggctcta gcgatgaaga tacagattga ggtactgaaa tgtgtgggcg tggcttaagg 3540 gtgggaaaga atatataagg tgggggtctt atgtagtttt gtatctgttt tgcagcagcc 3600 gccgccgcct taatgaacgg aactactcag aacaacgctg cgctttttga tggaggggtt 3660 tttagccctt atttgacttc caggttacca tattgggccg gagtacgtca gaatgtggta 3720 ggatctacag tggacggtcg acctgtggca cctgcaaatt catcaacatt aacctatgca 3780 actattggac cctcgccttt ggataccgcc gccgccgctg cagcttccgc ggccgcttct 3840 acggctcgca gtatggcagc tgatttcagc ttctacaatc acttggcttc gaatgctgtg 3900 acacgcaccg cagttcgaga ggacattctg actgttatgc ttgccaagct tgaaactcta 3960 actgctcagc tggaagagct atcgcaaaag gttgaggaat tagctgatgc tactacccat 4020 accccagccc aacctgtaac ccaataaaac ataaataaaa aaccagactc tgtttggatt 4080 tggatcaagc aagtaaattg agatggtgtt atgaatcttt attgatactt gttttttctg 4140 acatggtaag ctcttgacca ccgttcccta tcattaagaa cacggtgaat gtgttccagt 4200 attttgtaaa gatgagcctg tatattaagg tacattggca ttaggccatc tttgggatga 4260 aggtaggacc attgaagggc ttcatgttcc gggttagtgt tgtagataat ccagtcatag 4320 caacaacgct gggcatggtg attaaatata tcttttaaca acaagctaat tgctaatgga 4380 agacctttag tataggtatt gataaaacgg ttaagctggg tgggatgcat ccgaggtgac 4440 atgatatgaa gttttgattg tattttgaga ttggcaatgt tacctgccaa atctcttctt 4500 ggattcatat tgtggagaac cacgaaaacg gtgtagccag tacacttggg aaatttgtca 4560 tggagtttag aaggaaaggc atggaaaaac ttggaaacgc ctttgtgact tcccaaattt 4620 tccatacact catccattat tatggcaatt ggaccgcgag cagcggcttg agcaaaaatg 4680 ttttctggat cagaaacatc atagttgtgg tctagagtta ggtcatcgta ggacaactta 4740 acaaatttag gacacagcgt tccagattgt ggaataatag ttccctctgg tcctgggaca 4800 taatttccct cacaaatttg catttcccaa gatttaattt cagatggggg aatcatgtcc 4860 acttgcggaa caataaaaaa aacagtttct ggagcaggtg taaccagctg ggcagaaagc 4920 aaattacgca acaactgaga cttcccacag ccagtgggtc cataaattac cccaattaca 4980 ggttgcaagt gatagtttaa cgaggtgcag ctgccgtctt cgtggagaag cggagccact 5040 tcattcatca tttgtcggac gcggatgttt tgcttggcca gttcccctaa cagacgctct 5100 ccgcctaagg aaagtaactc ttgtaaagat ttgaaatttt taagtggctt taggccatcg 5160 gccataggca tgtggtccag ggtttgcttc agcagttgca agcgatccca tagctcagtt 5220 atattttcta tgccatctcg atccagcaaa cttcctcgtt gcgggggttt ggctggctgt 5280 tgctgtaagg aacgaggcgg tgagcatcca aatggacgag ggttttgtcc ttccagggac 5340 gtaatgtgcg cgtcagggtt gtttcggtca cggtgaatgg atgcgctcct ggttgagcgc 5400 tggccagtgt gcgctttaaa ctgaggcggc tggtgctgaa gcgcgtgtct tctccctgtg 5460 cttcggcaag gtagcatttt aacataagat cataagacaa agcctctgta gcgtggcctt 5520 tagcccgtat ttttcctttg gaggtgctcc cgcagtgagg acactgaagg catttaaggg 5580 cgtacagttt tggagccaaa aaaacagatt ctggagaata agcatctgcg ccacaataac 5640 tacaaacagt ttcacattca actgaccagg tcagctcagg acatgatgga tcaaaaacaa 5700 gtttccctcc gtactttttg atgcgtttct taccttgcga ctccataagg cggcgtcctt 5760 tctctgtgac aaaaagactg tcagtgtctc cgtatacaga tttaaggggt ctatccttca 5820 gtggtattcc gcggtcctcc tcgtacagga attctgacca ctctgacaca aaagctctag 5880 tccaagcaag tacaaaggaa gccacatggg aagggtaccg atcgttgtta attaaagggt 5940 tagaactttc taaggtgtgt aaacacatgt ctccttcttc agcgtccatg aatgtgattg 6000 gtttgtaggt gtaagtcacg tgttcacaat tttctggtgg tgggctataa aaaggggcgg 6060 gtccttggtc ttcatcgctt tcttctgctt cgctgtttac gagcgccaac tggttgggtg 6120 agtacacgcg ctcaaaggca ggcattacct ctgtactcaa cgtgtcagtt tctataaacg 6180 atgaggattt gatgtttaat cgccccgctg caatttcttt cattaggctt tcttccattt 6240 gatcagaaaa aactattttt ttgttatcta gtttggtagc aaaagatccg tacaaggcat 6300 tggaaagcag cttggctata gatcttaggg tttgattttt gtccctatcg gcccgttctt 6360 ttgcggcaat attgagttgc acatattcgc gtgccaggca tttccaggtg gggaaaatgg 6420 tggtgcgctc gtcagatagc aagcgtaagc gccacccgcg attatgcagt gtaaccagat 6480 ctacgctggt aactacttca ccgcgcaagc tttcattggt ccaggctaaa cgaccgcctt 6540 ttctagaaca aaaaggagga agaacatcca actgattttc atctgggggg tcggcatcta 6600 tagtaaaaat gccaggacaa agatttttgt caaaataatc aattttgcaa gtgtaatttt 6660 ccagcgccac ctgccattgc cgcacggcca atgcccgctc ataggggtta aggggaggac 6720 cccaaggcat ggggtgtgtg agggccgatg catacatgcc gcaaatatca tatacatata 6780 tgggctcttt tagtactcct atgtaagtag gatagcacct gccgccacga atgctggcgc 6840 gaacgtagtc atatagctca tgtgaaggcg ccaggatgtt gggcccaaga tgtgtgcgct 6900 gtggtttttc ggcgcggtac aaaatttgtc tgaaaattgc atgagagtta gaggaaatgg 6960 taggacgctg aaacacatta aaatgtgccg cgtcaagacc cactgcgtca gtaacaaact 7020 gggcgtatga gctacgcagt ttttctacca atgaggcagt cacaagtaca tccagggcac 7080 aatagtttaa tgtttccccg ataagattgt aatttttttc tccttttttt ttccatagtt 7140 cttgatttag gaggtattcc tccttatcct tccagtactc ctccagggga aacccatttg 7200 catctgcacg gtaagaacca agcatataaa actgatttac cgccttgtac ggacaacatc 7260 ctttttctac aggcagggca tacgcttgtg cagcctttct taaagatgta tgagtaagag 7320 caaaggtatc tctgaccatt acttttaaat actggtattt aaaatcttgg tcgtcacacc 7380 ctccgtgttc ccacagtagg aagttagttc gctttttgta gtggggattg ggaagggcaa 7440 aagtaatatc attaaataat attttgccag ctcttggaat aaaatttcta gaaattttaa 7500 agggtccagg gacgtccaag cggttattga ttacctgagc ggcaagaaca atttcatcaa 7560 atccattaat attgtgtcct actatataca actctacaaa tcttggctca cccttaattg 7620 caggggctct tttaagatct tcgtaggaaa gatcttcaag cgcgactagt ccgttttctt 7680 cttgagccca ttgagacaag tgtggatttt tttgtaaaaa agtcatccaa agatcagtag 7740 ctaaggaggt ttgtaagcgg tttctatagg tacgaaactg ttgaccgacc ttcatttttt 7800 ctggggttaa gcagtagaaa gtagtagagt ctttttccca ttggtcccat ccaagttcta 7860 atgcaagttg taaggcatgt ttgacaagat tgtcatcccc agacagtttc atcaccagca 7920 taaatgggac aagttgcttt ccaaatgccc ccatccaggt gtaggtttct acatcatagg 7980 taataaaaag gcgctcagtg cgaggatgcg aaccgattgg gaaaaagtgg atctcctgcc 8040 accagttgga agaatggctg ttgatgtgat gaaagtagaa atctcgtcgg cggacagagc 8100 attcatgctg atgtttgtaa aagcgtgcgc agtgttcgca tcgttgcacg ggctgtatct 8160 gttgaatgag gtgtacctgg cggcctcgca ccagaaagca gatgggaaaa tcaataccac 8220 ttggcagctg ccgttcgtcc tcttcctctt ctgctgcatt gccactaccg tttggatcct 8280 cgaaagcgag aacggagagg gtgacggtgc ccctcgacct gcatgtccag atttcagcac 8340 gagaggggcg gaaacgggaa atcagggcgt acagcctgga gctgtccatg gtatcagtca 8400 gagagaaaag catgtccgcg gggacagcgc gcaagttgac ttcgcacagg cgggtaagag 8460 caggctggag gtgcaggtaa tacttaattt ctagaggcgt gccgttggca gagtctattg 8520 cgtgaagtat tccatgagcc cggggactaa ccacggttcc acggtgcact tttccaatgc 8580 gcctgcttaa aatcggcggc gcggacgagc tcccggagga agcggcggtt cgggtcctgc 8640 gggaagcggg ggaagcggta tgtcggcctg acgctctggc aggggaaggt gttgagcccg 8700 aagttgactg gcatgggcga ctacccggcg attgatatct tgaatctgtc ggcgttgtgt 8760 aaacactacc ggccctgttg ttttgaacct gaaagaaagt tcaacagaat caatctcagt 8820 gtcatttact gcagcctgtc ttaaaatctc ctgaacgtcg cctgagttat cttggtaggc 8880 aatttctgcc attaattgat caatttcttc ctcctggagg tctccatgtc ccgcacgttc 8940 aatagtggct gcaaggtcat tagatatccg actcataagc tgtgaaaatg cgtttagtcc 9000 aatttcgttc cagactcggc tgtatactac ccctccttcg ctgtcccgag cgcgcataac 9060 cacttgcgcc aagttgagtt ccacgagccg tgcgaacacg ccgtagttgc gcaagcgctg 9120 aaacaggtag tttaaggtgg tggcaacgtg ttctgagacg aagaaataca gaatccaccg 9180 acgaagcgtc agctcgttga tgtcacctaa ggcttcaaga cgttccatgg cttcgtaaaa 9240 gtctactgca aaattgaaaa actgggagtt gcgagctgcc accgtcaatt cttcttccaa 9300 cagacgaata agctcggcca ccgtctcgcg cacttcttgc tgaaatgcgc ccggaactat 9360 ttcttgttct tcctcttcta cctccattat ttcttcctcg accacaggtg gtgggggttg 9420 tcttcttcga cgccggcgaa cgggcagcct gtctacaaat ctttcaatca tttcgccgcg 9480 acggcggcgc atagtttcgg ttactgctcg accgttttca cgtggtcgta actcaaaaac 9540 tccacctcta agttctgttt catgtaaaat gggaaatgag gcgttgcgag gggcgttagg 9600 tagggataca gcgctgatta tgcattttat tatttgctgc gtaggaactc cgcgcaagga 9660 gctaagcgtc tgcatatcca ccgggtcgga gaacctttca agaaaggcat ctagccagtc 9720 acagtcacaa ggtaggctaa gttttgtttc ttctaaagta ccaggaagct gagcaatgct 9780 actaataatg taattgaagt aagctgtttt aagcccacga atggttttaa gaagcaccac 9840 atctttgggt ccggcttgtt gaattcgcag gcggtctgcc attccccaca cgtcactttg 9900 acatcgtcca agatctttgt agtagtcttg cattaacctt tccacctcta cctcgcggtt 9960 tccgcgatca gccatgtgcg tgcttccgta gccttgcagc ggttgtaata aagctaaatc 10020 tgccactacc cgttccgcaa gcactgcctg ttgaatttgg gtaagggtgg ttgcaaagtc 10080 atccacatct acaaagcggt gataagctcc tgcattaatg gtgtagctgc agtttgtcat 10140 tactgaccaa ttaacagttt gcgtgcctgg ctgtacagtt tctgtgtatc gcaagcgtga 10200 gtaagcccga gagtcaaaaa catagtcatt gcaggtgcgc actaggtatt gatagcccac 10260 aaggaaatga ggaggaggtt cgcgatacaa cggccagcca agcgtagccg cagcacctgg 10320 agcgagatct tccaacatga ggcggtggta ttcatatatg tatctggaca tccatgtgat 10380 gccggcagcg gtagttgttg ctcgcataaa ttcgcgggct cggttccaaa tattgcgcag 10440 gggtaaaaag cgttcaatag ttgccacgct ttgaccggtc aggcgtgcgc agtcttgaat 10500 gctctggaca tggaaaaaat gaaagttggt aagcgactcc cttccgtggt ttggtggaaa 10560 agtcacaagg gtaccatagc gaggaacccc ggttcgaaac cggcaggatc cgctatgagc 10620 acaagtgagg cgcttgcgcg ttgaacccgg ccaaggaccc ccagacacgg agaggagtct 10680 ttttttattt attttttctt agatgcatcc tgtcctgcga caaatgcgac ctcagcccag 10740 ggcaaccacg gcctcagcag cggtggcgct ttcgggctct ggcgaacagg aagagcctca 10800 atgtcctaca ttggagttgg aagaaggaga aggcatagcc cgattgggcg cccactctcc 10860 tgagcgtcac ccaagggtgc agctcgcccg ggacagtcgc gtggcatttg tgcctcgtca 10920 gaacatgttt cgcgacaaca gcggggagga agctgaggaa atgcgagact gcaggtttag 10980 ggccggtcgc gagctgcgcc gcggatttaa tcgcgagcga ctgctgcgtg aggaggactt 11040 tgagccagat gaacattcgg ggattagttc tgcacgggcc catgtatcag cagccaactt 11100 agtaacagca tatgaacaaa cggttacaga ggaacgtaac tttcaaaaaa gctttaataa 11160 ccatgtgcgc acactaatag cgcgagaaga agtagccatt ggtttaatgc atctttggga 11220 ctttgtagaa gcttatgtac ataatccagc aagtaaaccc ctaactgccc agctgttctt 11280 aatagttcaa catagtagag acaatgaaac ttttagggat gcaatgctta acatagctga 11340 accccagggt cggtggttac tcgatttaat taacattctg cagagcattg tggttcagga 11400 acgcagtctt agtttggcag acaaggtggc cgccattaat tactccatgt taagtttggg 11460 aaagttttat gctcgtaaaa tctacaaaag tccgtatgtt cccattgaca aggaagtgaa 11520 gatagacagc ttttatatgc gcatggcttt aaaggtacta acattaagcg acgatcttgg 11580 agtgtaccgc aatgaccgaa tccacaaagc agtaagcgcc agtcgccgca gagagctaag 11640 cgacaaagag cttatgcata gcttacaaag ggcgctgacg ggagcaggaa cagaggacga 11700 gtcgttcttt gatatgggcg cagacctacg gtggcagcca agcgctcgcg ctttggaggc 11760 agctggagtg gcgtctgctg acgtcactgg cgatgacgat gacgaagacc agtacgagga 11820 ctgatcggcc gtaccttttg ttagatgcag cgaccggcga tcatcgcgga gagggctcct 11880 aacctggatc ccgcggtttt ggcggccatg caaagccagc cttctggcgt tacagcttca 11940 gatgactgga cagcggccat ggatcgtatt atggctttaa cggcgcgcag tcctgatgct 12000 tttcgccagc agccccaagc taaccgcttt tcggccattt tggaagcagt agtgccgtct 12060 cgtactaacc ctactcacga gaaagtgtta accattgtaa atgctttgtt ggatagcaaa 12120 gccatccgca aagatgaggc tggtttaata tacaacgctt tgcttgagcg cgtggcacgc 12180 tataacagta ccaatgtgca ggctaactta gaccggatgg gtacagatgt aaaggaggcg 12240 ctggctcaac gagagcgctt tcatcgcgat ggtaatcttg gttcgctagt agcattaaac 12300 gcttttttga gtactcagcc ggctaatgtt ccgcgtggtc aggaagatta tacaaacttc 12360 atcagcgcct tgcgactaat ggttactgaa gtgcctcaaa gtgaagtgta tcagtctgga 12420 cccgattact tttttcaaac gtccaggcag ggtttgcaaa ccgtaaactt aactcaggct 12480 tttaaaaatt tgcaaggttt gtggggggtt cgtgctccag taggcgatcg ttcaactttg 12540 tccagtttac taacaccaaa ctcgcgccta ttactgttgc taattgcccc ctttaccaac 12600 accaacagtt taagtcgaga ttcatacctg ggtcacttag ttactttgta ccgcgaagcc 12660 attggtcaag cgcaggtaga cgaacaaact tatcaagaaa taaccagtgt tagtcgcgca 12720 ctgggccagg aggacactgg cagtttagag gccacactta actttttact aactaaccgt 12780 cgccagcaag tgcctcctca gtacacttta aatgcggaag aagaacgcat attgcgctat 12840 gtacagcaat ctgtaagttt gtatcttatg cgtgagggtg ccacccccag tgccgcctta 12900 gacatgacag cgcgcaatat ggagccgtcc ttctacgctt ccaatcgagc tttcattaat 12960 cgcttgatgg attaccttca ccgcgctgcg gccatgaacg gggaatactt tacaaatgca 13020 attctaaatc cgcattggtt gccccctcct ggattttaca ctggtgaatt tgatttgccg 13080 gaaggaaatg atggcttttt gtgggatgat gttacggaca gtctgtttag tcctgcagtt 13140 attggacacc atggtaaaaa ggaagcaggt gatgaaggtc ccttgcttga ctctcgggcg 13200 agttctccat tccccagttt aactagttta cccgccagtg ttaacagcgg tcgtaccacc 13260 agaccccgac taacaggtga aagtgaatac ttaaatgacc ccatcttgtt tccagtgcgc 13320 gacaaaaatt ttcccaacaa tggcatagaa agtttggtag ataaaatgtc tcgctggaaa 13380 acatatgcac aagagcggcg agaatgggag gaaagacagc caagaccagt tcgccctcct 13440 aggcaacgtt ggcagcgacg caaaaaaggg gcacatgcgg gggatgaagg aagcgatgac 13500 tcagctgacg acagtagtgt attagattta ggagggtcag gaaacccatt tgctcatttg 13560 cgcccacagg gttgcatagg gtcattgtat taaattgaat aaaagcatac ttaccaaagc 13620 catggcgacc agtgttcgtc ttattttcct tcttccgtta gctgtgaaat gaggcgcgcg 13680 gtggaactgc agacagtggc ttttcctgag acaccacctc cctcttacga aaccgtgatg 13740 gcagcggcgc caccctacgt gcctccccgc tatttgggtc ctacggaggg aagaaacagt 13800 atccgttact cggaattgtc accgttgtac gataccactc gagtgtactt ggtggacaac 13860 aagtcttctg acattgcttc attgaattac cagaatgatc acagcaactt tttaaccact 13920 gtagtgcaaa ataatgacta ttcccctata gaggctggca cgcaaactat taactttgat 13980 gaaaggtcta gatggggtgg agatttaaaa accatcttac ataccaacat gccaaacgtg 14040 aacgatttta tgtttaccac caaatttaag gccagggtaa tggtggctag gaaaacaaac 14100 aacgaaggcc aaaccatttt agaatatgag tgggcagaat ttgtgctacc cgagggtaac 14160 tattcggaaa ccatgactat tgacttaatg aacaatgcta ttattgagca ttatttgcga 14220 gtaggaagac agcatggagt gctggaaagt gacattggag ttaagtttga caccagaaac 14280 tttcgtctgg gttgggaccc cgaaacccaa ttagtaactc cgggagtgta cactaatgag 14340 gcttttcatc cagatatagt actgcttcca ggttgcgggg ttgattttac agagagcaga 14400 ttaagcaaca tactaggtat aagaaagagg cagccgtttc aggaaggatt tgtgattatg 14460 tatgaacact tagagggagg caatattcca gctcttttgg atgtaaaaaa atacgaaaac 14520 agtctgcagg atcaaaacac tgtaagagga gacaacttta ttgccttaaa taaggctgct 14580 aggattgaac cggttgaaac agaccccaaa ggacgcagtt acaacttgct tccagacaaa 14640 aaaaatacta aatatcgcag ctggtatttg gcatacaact acggagaccc agaaaaagga 14700 gttcggtcat ggactctact aacaactcca gatgtaacag gcggctccga acaggtgtac 14760 tggtccctac ccgatatgat gcaagatccg gtgacttttc gctcctcgcg tcaagttagc 14820 aactatcctg tagttgcagc agaattactg ccagttcatg ctaaaagctt ctacaacgag 14880 caagccgtct actcacagct tattcgccag tcaaccgcgc ttacgcgcgt gtttaatcgc 14940 tttcccgaga accagatact ggtgcgtcca ccagccgcta ccatcactac cgtcagtgaa 15000 aacgttcccg cccttacaga tcacgggacc ctgccgctgc gtagcagtat cagtggagtt 15060 cagcgagtca ccatcactga cgcccgccgc cggacctgtc cctacgttta caaagcactg 15120 ggcatagttt ctccacgagt gctttctagt cgcacttttt aaaaaagtgt ggtaacatgt 15180 ccattttggt ttcgccaagt aacaacacgg gctggggact gggtgccgcc cgcatgtatg 15240 gaggagctaa aacaaggtct agccaacatc cagtgcgcgt acgcggacat taccgagctc 15300 catggggcgc gcatacccga ggacgcactg gtcgcaccac tgtagacgat gttattgact 15360 cggtagtggc cgatgctcgc aagtaccgcg cgcccgctga aacagcaggg tctactgttg 15420 atgcagtaat tgatgaggta gtggcaaacg cgcgggctta tgcaaggcgc cgcagacggc 15480 tgcgtcgccg gcgtagacca accaccgcca tgcgcgcggc cagagcgttg gttcgacggg 15540 ccaggcgcat tgggcggcga gctatgatgc gggcagccag gcgggctgca acgcctgccg 15600 gtcgagcgcg gagacgggcc gcagctgcgg ccgcaacagc tattgcaaac ctagctgctc 15660 cgcgacgagg aaatgtatac tgggtgcgcg actcagtgac cgggacgcgt gtgccagttc 15720 gtacgcgtcc acctcaccct tagaagacaa agagtgactc aatgtctgtt atgtatgccc 15780 agcatgacca aacgcaagtt caaagaagag ctgctgcagg ccttagcgcc tgaaatatat 15840 ggcccatcgg ataaccttac caagcgcgat atcaagcatg ttaaaaaacg ggaaaaaaaa 15900 gaggaagaag tcgccgcggc gtcagcagac ggcgtcgagt ttgtgcgctc atttgcgccc 15960 agacgtaggg tacagtggaa gggacggcaa gtaaaacgca ttttgcgacc gggcaccaca 16020 gtggtttttt ctcccggaga gcgaacgatt atgcgtcccc taaagcgcga gtacgacgaa 16080 gtgtacgcag acgatgacat tttggagcaa gcggcacaac agactgggga atttgcatat 16140 ggaaaaaaag ggcgttacgg agacaaaatt gctattcctt tggacgaggg aaatccaaca 16200 cccagtttaa aggctgtcac tttgcaacaa gtgttgcccg tccttgggcc ttcggaagaa 16260 aagcgtggaa ttaaaaggga agccatggat gaattgcagc ctacaatgca actgatggtg 16320 cctaagcggc aaaagttaga ggacgtacta gagcacatga aggtggatcc tagcgtacag 16380 ccagatgtaa aagtacgtcc gataaaaaag gtagctccag gattgggagt tcaaacagtg 16440 gacattcaaa ttcctgtgca aactgcattg ggtgaaacta tggaaatcca aacttcgcca 16500 ataaaaacaa cggtgaacgc aagcgtgcaa acagaccctt ggtacccgcc agtgctttca 16560 acaaaaaaaa agcgtcacta cagacaaaca agttcgcttt tgccagacta cgttttacat 16620 ccttccattg tgcccacgcc tgggtaccgt gggacaactt ttcagcgccg agccacagcc 16680 cctagccgta gacgaggtcc atcacgccgt agacgtcgac gcaaagccac tttagcccca 16740 gcggcagtac gtcgcgttgt acaaaggggg cgcacactaa tacttccatc cgtgcgttac 16800 caccctagca ttctctaaca agctgcgctg ccgttttttc agatggctct tacttgccga 16860 atgcgcatac ccattccagg atacagagga cgaccccgcc ggaggaaagg gctgaccggg 16920 aacggtcgat ttcggcggcg tagtatgcgc agacgcatga agggtggggt gctgcccttc 16980 ctaattccac ttattgctgc ggccattgga gccgttcccg gaattgcctc agtagccttg 17040 caggcttctc gaaaaaatta aaataaaata aaacttccaa cttattactg gtactatgac 17100 tgttttatgc agactaaatg gaagacatca atttttcgtc gctggccccg cgacacggca 17160 cgcggccgta catgggcacc tggaacgaga tcggcacgag ccagctgaac gggggcgcct 17220 tcaattggaa cagtatctgg agcggtctta aaaattttgg ttccacgatt aagacatatg 17280 gcaccaaggc gtggaacagc caaaccggcc agatgctaag ggacaagtta aaagaccaaa 17340 attttcaaca gaaagttgta gatggtctgg cttcgggaat taatggagtt gtagacatag 17400 ccaatcaggc tgtacagaaa aaaattgcca accgtttaga gccgcggccc gacgaggtaa 17460 tggtagagga aaagctgcca cctctagaaa ctgtgcccgg atccgttcca accaaaggag 17520 aaaagcggcc acggccggat gcagaggaaa ccttagtaac gcacacaaca gaaccgccgt 17580 cctatgagga agcaataaaa caaggagccg ctctgtcacc taccacctat cccatgacca 17640 agcctatttt acccatggct actagagtgt atggaaaaaa cgaaaatgtg cctatgaccc 17700 ttgagctgcc tcctttgcca gaacccacta tcgcggatcc cgtaggttcc gttcctgttg 17760 catctgttcc agttgcatcg acagtgagcc gtccagcagt gcggcctgtt gccgtggcta 17820 gcttgcgaaa cccacgatcc agtaattggc aaagtaccct aaacagtatt gtgggactgg 17880 gagtaaagtc tctcaaacgc cgacgctgct actaacatta aaagacgagt gttaattccc 17940 atctgtgtat acgcctccta tgttagcgcc agaggaccaa cgcgtgaatc gcagtcacca 18000 ccagcgcttt caagatggcc actccctcga tgatgccgca gtggtcttac atgcacatcg 18060 ccggtcagga tgcctcggag tacctgagtc ccggtctggt gcaattcgcc cgcgccacgg 18120 acacctactt caccctggga aacaagttta gaaaccccac cgtggctccc acccatgatg 18180 ttaccaccga tcgctcgcag cgtctgacgc tgcgttttgt gcccgtggat cgggaagata 18240 ctacctactc ctacaaggct cgctttacgc tggctgtggg tgacaaccgc gtgttagaca 18300 tggctagttc ttactttgac attcgagggg tactggatcg tggtcccagt tttaagccct 18360 attccggaac cgcctacaat tctttggcac caaaaggcgc tcctaatgct tcacaatggt 18420 cagataacgc taagcttaat acctttgctc aggcgccgta tcttagcgac actatcaccg 18480 ccgccgatgg tattaaagtt ggaacagaca ccgcccaggc aggcgcggcg gtgtatgcca 18540 acaaaactta tcagccagag ccgcaagtag gaccaagtga atggaacacc agcattgaaa 18600 acgttaaagc tggcgggagg gcattaaagc aaaccactgc aatgcagccg tgctatggct 18660 cctacgctcg tccaaccaac gaacacggag gacaatccaa ggatgacaac attgaactta 18720 agttctttga ttcagctaac aatgcagcaa acactgctca agttgtgttc tataccgaag 18780 acgtaaacct tgaaatgcca gacacgcatc ttgtgtttaa gcctactgtt accaatggaa 18840 caattgcttc tgagtcgctg ttgggacagc aagcagcgcc aaatagagca aactacattg 18900 cattcagaga taattttatt ggcctgatgt attacaacag tacaggcaac atgggtgtat 18960 tggccgggca agcttcccaa cttaacgcag tagtagacct gcaagacaga aatacagagc 19020 tgtcatacca gttaatgctg gatgctttgg gagacagaac acggtacttt tccttgtgga 19080 attccgcagt ggacagttac gaccctgacg ttcgcgttat tgagaatcac ggggtagagg 19140 atgaactacc aaattattgc tttcctctta gcgcagtagg tgaaataaaa aattacaaag 19200 gcattaagcc agataacgga ggaggaggtg gctggactgc cgacaacact gtcagtgaag 19260 caaaccacat aggcattggg aatatagccg ccatggaaat taatttgcag gctaatttgt 19320 ggagaagctt cttgtactca aatgtgggct tatacctacc agacgactta aaatacactc 19380 caggaaacat aaaactacct gataacaaga acacctacga gtacatgaac gggcgtgtga 19440 ctgccccggg gttggtggat acctatgtca atatcggcgc tcgctggtcc ccagatgtga 19500 tggataatgt aaaccctttt aaccaccacc gaaacgcagg gttgcgctac agatccatgt 19560 tgctaggcaa tgggagattt gttccttttc acattcaggt gccgcaaaaa ttttttgcca 19620 tcagaaattt gttgctgttg cccggttcct acacttacga atggcggttc ctacacttac 19680 gaatggaact ttagaaagga tgtaaacatg attcttcaga gcacactggg aaatgatctt 19740 cgggtggacg gagccagcgt tcgctttgac aacattgccc tgtatgctaa cttttttccc 19800 atggcacata acacagcttc tactttagaa gccatgttaa gaaatgacac caacgaccag 19860 tcttttaacg attatttgtg tgctgcaaac atgctgtatc ccatcccagc taacgccacc 19920 agcgtgccca tttcaatacc ttcgcgaaat tgggcggcat ttagaggctg gagctttact 19980 cgcctaaaaa ctaaagaaac tccttccctg ggttcagggt ttgaccccta ctttgtatac 20040 tctggaacca ttccctattt agacggcacc ttttacctaa accacacttt taagaaggtg 20100 tcaatcatgt ttgactcctc cgtgagttgg cctggaaatg accgtttgct aaccccaaat 20160 gaatttgaaa taaagcgttc tgtggatggg gagggataca atgtggccca atgcaatatg 20220 actaaggatt ggttcctaat acaaatgctt agtcattaca acattggata ccaaggtttt 20280 tacattccag agagctacaa ggaccgcatg tattctttct ttagaaactt tcagcccatg 20340 agtaggcaag ttgtggatac cacagaatat aagaactaca aaaaagtaac cgtagagttt 20400 caacataaca actcaggatt cgtgggatac ctgggcccca ctatgcggga gggacaagct 20460 taccccgcca actatcccta ccctcttata ggccaaacag ctgtggaaag catcacacag 20520 aaaaagtttc tatgcgatcg tgttatgtgg cgcatcccat tttctagtaa cttcatgtct 20580 atgggggcgc taacggatct tgggcaaaat atgctgtacg caaactcagc ccatgctcta 20640 gacatgacat ttgaggtgga tccaatggat gagcctaccc ttctttatgt tttatttgaa 20700 gttttcgacg tggtacgcat tcaccagcca caccgcggcg tcattgaagc ggtctacctg 20760 cgcacgccct tctcggcggg taacgctacc acctaagaag gcaccctccc agactgctgt 20820 aatgggttca agcgaacagg agctgacggc cattgttcga gatctaggct gtggacccta 20880 ttttttggga acctttgaca aacgttttcc gggttttgtg tctcgcgacc gcttatcatg 20940 tgctattgtt aacactgccg gtcgcgaaac tgggggcgta cactggctgg cttttggatg 21000 gaaccccaaa tcgcacactt gctatttatt cgatccattt ggattttctg atcaacgact 21060 aaaacaaatc tatcagtttg agtacgaaag tctgttgcgc cgtagtgcgc tagcggccac 21120 taaagaccga tgcgttaccc tagaaaagtc aacccaaact gtacaaggac cgttttctgc 21180 agcgtgcggc ctgttttgtt gtatgttctt acacgctttt actcactggc ctgaccatcc 21240 aatggataaa aatcccacta tggacctact tactggggtg cctaattgta tgctacaaag 21300 tcctcaggta gtgggcacat tgcaacgcaa tcagaatgaa ttgtataaat tcttaaacaa 21360 tctgtcccct tactttcgtc acaaccgcga gcgcatagaa aaagctacat cttttactaa 21420 aatgcaaaat ggactcaaat aaacgtgtac acaatgcatt aataataaaa ccattttatt 21480 agctcattgg agtacaagct tgactgtttt attaaaaatc aaatggctct tcgcgacagt 21540 cgccgtggtt ggtgggcagg gatatgtttc tgtactgcaa acgctgatgc cacttgaatt 21600 ctggaataac aagcctaggg ggggagccgt caaaattttc tccccacagc tggcgcacaa 21660 gttgcagggc gcccataaca tcaggagcag aaatcttgaa gtcgcaatta gggccagcat 21720 tgccgcgcgc attgcgataa actggatttg cgcactgaaa aaccaacaaa cacggatact 21780 taatactggc taacgctcca gggtcggtta cttcgttgat atcaatgtta tccacattgc 21840 tgaggttaaa aggagtgatt ttacacagtt gacgccccat ccgtggcagg ccatcttgct 21900 tgtttaaaca ttcgcagcgc actggcataa ggagacgttt ttgcccatgt cgcatgtgag 21960 ggtagtcggc cagcataaaa gcttcaattt gcctaaaagc tatttgagcc ttcattcctt 22020 cagaataaaa caagccgcag gactttccgg agaaagaatt attcccgcag ccaacatcat 22080 gaaaacagca gcgggcatcg tcgtttttaa tttgaactac attacgcccc cagcggtttt 22140 gcgccacctt ggctttcgag gggttctctt tcaacgctcg ttgcccactt tcgctggtta 22200 catccatttc caccaaatgc tctttgcgca ccatctccat tccatgcagg catctaagct 22260 ccccttcgcg ctcggtacac ttatgctccc acacgcagca accggtgggt tcccaggaat 22320 tctgttggac accggcataa gcttgcatat atccttgcaa aaagcgtccc atgagctcct 22380 gaaaggtttt ttgggatgaa aaagtcagct gcaaaccgcg cttttcttcg ttgagccatg 22440 ttgtgcatat tttcttgtac acgctgccct gatccggcaa aaaacgaaag gtggcgcgct 22500 cgtcgtgatc cacatggtac ttttccatta gcatagccat ggcttccatg cctttttccc 22560 aagctgaaac taggggctgg cttgccggat tgcgaacaac aacaacattc ttttcatttt 22620 cgtcgctgtt ttgagcggaa gccttcaaaa cgtgtacctg cctggtttcc attttttgaa 22680 aagactgaga accgtctgca tgatgcataa tgcggacggg cggcatgctg aaacccatta 22740 ctcctaaaac tgctcttggt ggttctgcct cttcttcttc tgcactctct ggggaaagag 22800 gtatcgcagc catagatttc ttgacttttt tctttggagg taaaggcaca gcttccagtt 22860 cttcttcgct ttcggaatcc agaaagtatc tgcccatttt tggcggcggc ggctgagcgc 22920 tgcggtctgg ggtgcgctcc ctctgtgagt gctgattgct ggccattatt taatcctagg 22980 caaagaaaca catgatggat ctggagccac aggaaagctt aaccgccccc accgctcccg 23040 ccattggcgc tacggctgtc atggagaagg acaaaagtct actcataccc caagacgcac 23100 cggttgagca gaacttgggc tacgagactc cccccgagga atttgaaggc tttcttcaaa 23160 tccaaaagca accaaatgag caaaacgctg ggctcgagga ccatgactac ctaaacgagg 23220 gagatgtcct gtttaaacat ctacagcgac aaagcactat cgttcgcgac gccatatctg 23280 atcgctcttc aataccagtt tcaattgcag aactatcttg catctacgaa cgcaacctgt 23340 tctccccacg tgtgccccct aaacggcaag ccaacggcac atgcgagcca aatcctcgcc 23400 ttaacttcta cccagttttt gcagtgccag aagcactggc aacataccat attttcttta 23460 aaaatcacaa aataccccta tcctgtcgag ctaaccgcag ccgcgcagat gagcttcttg 23520 ctttaagggc tggcgcttcc atacctggga ttgtgtcctt ggaagaggtg cctaaaattt 23580 ttgaaggttt aggtcgggat gaaaaacgag cagcaaatgc cctgcaaaaa gaaaatgaac 23640 aaaatcacca tgggaatagt gctctaatag aactggaagg tgacaatgcc cgcctggcag 23700 ttttaaagcg caatattgag gttactcact ttgcctaccc ggcagtaaat cttccgccaa 23760 aggtaatgag cgcagtgatg aatcagctac taattaagcg agcccaaccc attgacaaag 23820 atgcaaactt gcaagacccg gaggcaacag atgatggaaa gccggttgta agcgacgagc 23880 aattaactaa gtggttggga acagacaatt ccaacgaact acaacagcgg cgtaaactca 23940 tgatggccgc cgtacttgta actgtggaac tcgagtgcat gcatcgtttt ttctccgaca 24000 tcaccacatt gcgcaaaatt gaggaatgtc ttcactacac tttccgccat ggctacgtgc 24060 gccaagcctg taaaatttct aatgtggagc tgagcaatct agtttcttac atgggcatct 24120 tgcatgaaaa ccgattggga cagaacgtgc tacactcaac actacgcgat gaagcacgca 24180 gagattacgt gcgagactgc atttaccttt tcctgttaca tacctggcaa actgggatgg 24240 gtgtttggca gcaatgcttg gaagaaaaaa accttcgaga actaaacaaa ctgttagaca 24300 gagcactaaa atccctatgg accggttttg acgaacggac agtagctgca gagctagctg 24360 acataatttt cccagaaagg ttaatgataa ccttgcaaaa cggcttgcct gactttatga 24420 gtcaaagtat gctgcacaat tatcgctctt ttatattaga gcgttctggg atgcttccta 24480 gcatgtgttg tgcacttcct tcagattttg tgcctatata ttttagagag tgcccccctc 24540 ccctgtggag ccactgctac ttactacgac ttgctaacta cctagcttac cactcagacc 24600 ttatgacaga ttcaagcggc gaaggcctaa tggagtgtca ctgccgctgc aatctttgca 24660 ccccccaccg ttctttggtt tgcaatactg aactattaag tgaaagtcaa gtcattggta 24720 ccttcgaaat gcagggaccg cagtctgaca gcaatttcac gacgaaccta agacttaccc 24780 ctgggctttg gacttctgcc tacctgcgca aatttgaacc ccaagattac cacgcccaca 24840 gtatcaattt ttacgaagac caatccaaac ccccaaaagc gccactaacg gcttgcgtca 24900 ttacgcaggg aaaaattcta gcccaattgc atgctattaa gcaagcgcgc gaagagtttt 24960 tacttaaaaa aggacacgga gtgtaccttg atccccaaac cggcgaggaa ctaaaccttc 25020 catcaccttt gtgtgctact gcgtctcccc attcgcagca tgtccccgaa agccgcaaaa 25080 caggctattg cgcagcaacg ctcaaagaaa cagcagcaac ggcaggaaat ctgggaggaa 25140 gaatcttggg agagtcaggc agaggacgag gtcgaggact tggaagaatg ggaggaggag 25200 gaggcggaca gcctagacga ggatccagag gaggaggagg aaggttccaa ggacggagcg 25260 accgccgcca aaccgtcgct ttcaaccaag ccctctccaa tgaaacccgc tgtgagcaaa 25320 tctcagaaag ccaaccgtag atgggacacc attgaaacca gcgccgcaaa cttgggtaag 25380 aatcgcaagc aggcgcgtcg gggctactgc tcatggcggg ctcaccaaag taatattgta 25440 gcctgctttc agcactgcgg ggggaatatc tcatttgcaa ggcggtattt gctataccat 25500 gatggagtgg cgattccaag gaatgtcctc cattactacc gtcatctcta cagccccttt 25560 gaagagctcg acaaggaacc gacctgcaac agccaagcgg cccactagaa tcggcaacag 25620 cagcaacaag gaaagtcctg aggcgcgcga gttaagaaaa cgcatttttc ccactttata 25680 tgctattttt cagcagagtc gaggtcaaga acacgaactg aaaataaaaa accgttccct 25740 gcgttcactt acccgcagct gtctctacct caaaagcgaa gatcagttgc aacgcacctt 25800 gcaggacgca gaagctctgt tcaataaata ctgctccctc tcgcttaaag agtaaaaaaa 25860 gcccgcgcgc ggactttcaa caggcgggaa aagtgacgtc acaacaagat gagtaaagat 25920 attcccacgc cttacatgtg gagctttcaa ccccaaatgg gactggcggc cggcgcggct 25980 caagactatt ctagcaaaat gaattggtta agcgccggac cccacatgat ttccagggtg 26040 aatggggtac gagcccggcg taaccaaata ctgctagaac aagccgctct caccgctaca 26100 ccacgtaatc aacttaaccc tccctcttgg ccagctgccc tgatatatca ggaaaatccc 26160 cctcctacca ctgtactttt gcctcgcgac gcccaggccg aagtccatat gactaacgct 26220 ggggcacagc ttgcgggcgg tgcacgtcac agtttcaggt ataaaggtcg cactgagccc 26280 tatccgtctc cagctataaa aagagtactc atcagaggga aaggtattca gctgaacgac 26340 gaagtcacat cgccattggg agtcagaccc gacggagtgt ttcagctcgg agggtccgga 26400 cgttcctcct ttaccgctcg tcaagcctac ctgacactac agagctcatc ctcagctccg 26460 agatctggtg gtattggaac tctccaattt gtggaggaat ttactccatc tgtttacttc 26520 aatccttttt cgggctcgcc tggacactat cctgacgcct tcatacccaa ctttgacgca 26580 gtgagtgaat ctgtggatgg ctatgattaa ggatgttaag tggagaggca gagcaactgc 26640 gcctgaaaca cctggtccac tgtcgccgcc acaagtgctt tgcccgcgac tccggtgagt 26700 tttgctactt tgaattgccc gaggatcata tcgagggccc ggcgcacggc gtccggctta 26760 ccgcccaggg agagcttgcc cgtagcctga ttcgggagtt tacccagcgc cccctgctag 26820 ttgagcggga caggggaccc tgtgttctca ctgtgatttg caactgtcct aaccctggat 26880 tacatcaaga tctttgttgc catctctgtg ctgagtataa taaatacaga aattaaaata 26940 tactggggct cctatcgcca tcctgtaaac gccaccgtct tcacccgccc aagcaaacca 27000 aggcgaacct tacctggtac ttttaacatc tctccctctg tgatttacaa cagtttcaac 27060 ccagacggag tgagtctacg agagaacctc tccgagctca gctactccat cagaaaaaac 27120 accaccctcc ttacctgccg ggaacgtacg agtgcgtcac cggccgctgc accacaccta 27180 ccgcctgacc gtaaaccaga ctttttccgg acagacctca ataactctgt ttaccagaac 27240 aggaggtgag cttagaaaac ccttagggta ttaggccaaa ggcgcagcta ctgtggggtt 27300 tatgaacaat tcaagcaact ctacgggcta ttctaattca ggtttctcta gaatcggggt 27360 tggggttatt ctctgtcttg tgattctctt tattcttata ctaacgcttc tctgcctaag 27420 gctcgccgcc tgctgtgtgc acatttgcat ttattgtcag ctttttaaac gctggggtcg 27480 ccacccaaga tgattaggta cataatccta ggtttactca cccttgcgtc agcccacggt 27540 accacccaaa aggtggattt taaggagcca gcctgtaatg ttacattcgc agctgaagct 27600 aatgagtgca ccactcttat aaaatgcacc acagaacatg aaaagctgct tattcgccac 27660 aaaaacaaaa ttggcaagta tgctgtttat gctatttggc agccaggtga cactacagag 27720 tataatgtta cagttttcca gggtaaaagt cataaaactt ttatgtatac ttttccattt 27780 tatgaaatgt gcgacattac catgtacatg agcaaacagt ataagttgtg gcccccacaa 27840 aattgtgtgg aaaacactgg cactttctgc tgcactgcta tgctaattac agtgctcgct 27900 ttggtctgta ccctactcta tattaaatac aaaagcagac gcagctttat tgaggaaaag 27960 aaaatgcctt aatttactaa gttacaaagc taatgtcacc actaactgct ttactcgctg 28020 cttgcaaaac aaattcaaaa agttagcatt ataattagaa taggatttaa accccccggt 28080 catttcctgc tcaataccat tcccctgaac aattgactct atgtgggata tgctccagcg 28140 ctacaacctt gaagtcaggc ttcctggatg tcagcatctg actttggcca gcacctgtcc 28200 cgcggatttg ttccagtcca actacagcga cccaccctaa cagagatgac caacacaacc 28260 aacgcggccg ccgctaccgg acttacatct accacaaata caccccaagt ttctgccttt 28320 gtcaataact gggataactt gggcatgtgg tggttctcca tagcgcttat gtttgtatgc 28380 cttattatta tgtggctcat ctgctgccta aagcgcaaac gcgcccgacc acccatctat 28440 agtcccatca ttgtgctaca cccaaacaat gatggaatcc atagattgga cggactgaaa 28500 cacatgttct tttctcttac agtatgatta aatgagacat gattcctcga gtttttatat 28560 tactgaccct tgttgcgctt ttttgtgcgt gctccacatt ggctgcggtt tctcacatcg 28620 aagtagactg cattccagcc ttcacagtct atttgcttta cggatttgtc accctcacgc 28680 tcatctgcag cctcatcact gtggtcatcg cctttatcca gtgcattgac tgggtctgtg 28740 tgcgctttgc atatctcaga caccatcccc agtacaggga caggactata gctgagcttc 28800 ttagaattct ttaattatga aatttactgt gacttttctg ctgattattt gcaccctatc 28860 tgcgttttgt tccccgacct ccaagcctca aagacatata tcatgcagat tcactcgtat 28920 atggaatatt ccaagttgct acaatgaaaa aagcgatctt tccgaagcct ggttatatgc 28980 aatcatctct gttatggtgt tctgcagtac catcttagcc ctagctatat atccctacct 29040 tgacattggc tggaacgcaa tagatgccat gaaccaccca actttccccg cgcccgctat 29100 gcttccactg caacaagttg ttgccggcgg ctttgtccca gccaatcagc ctcgcccacc 29160 ttctcccacc cccactgaaa tcagctactt taatctaaca ggaggagatg actgacaccc 29220 tagatctaga aatggacgga attattacag agcagcgcct gctagaaaga cgcagggcag 29280 cggccgagca acagcgcatg aatcaagagc tccaagacat ggttaacttg caccagtgca 29340 aaaggggtat cttttgtctg gtaaagcagg ccaaagtcac ctacgacagt aataccaccg 29400 gacaccgcct tagctacaag ttgccaacca agcgtcagaa attggtggtc atggtgggag 29460 aaaagcccat taccataact cagcactcgg tagaaaccga aggctgcatt cactcacctt 29520 gtcaaggacc tgaggatctc tgcaccctta ttaagaccct gtgcggtctc aaagatctta 29580 ttccctttaa ctaataaaaa aaaataataa agcttattac ttaccggaaa tctgaaaata 29640 catcatggtc tccgtgtact cttataaaat ttccctcttc ccaactgtca aacctgacag 29700 acttgcaaac agcaaacttt ctccaaatct taaatggaag gtcagattct tcttcccaat 29760 ccctacccac catcttcatc ttttctagat gaagcgcagc agaacccagt atgctgaaga 29820 aacagaagaa aatgatgact tcaaccccgt ttaccctttt gacccatttg acacatcaga 29880 cgtacccttt gttacacccc cttttacttc ttccaatggt cttcaagaaa aaccaccagg 29940 tgtattagca cttaattaca aagaccccat tgtaactgaa aatggaaccc ttacactcaa 30000 gctaggggac ggaataaaac ttaatgccca aggtcaactt acagctagta ataatatcaa 30060 tgttttggag ccccttacca acacctcaca aggtcttaaa ctttcttgga gcgcccccct 30120 agcagtaaag gctagtgccc tcacacttaa cacaagagcg cccttaacca caacggatga 30180 aagcttagcc ttaataaccg cccctcccat tacagtagag tcttcgcgtt tgggcttggc 30240 caccatagcc cctctaagct tagatggagg tggaaaccta ggtttaaatc tttctgctcc 30300 cctggacgtt agtaacaaca atttgcatct caccactgaa actcccttag ttgtaaattc 30360 tagcggtgcc ctatctgttg ctactgcaga ccccataagt gttcgcaaca acgctcttac 30420 cctacctacg gcagatccgt taatggtgag ctccgatggg ttgggaataa gtgtcactag 30480 tcccattaca gtaataaacg gttccttagc cttgtctaca actgctcccc tcaacagcac 30540 aggatccact ttaagtctgt ctgttgccaa tcctctgact atttcacaag acacattgac 30600 tgtttccact ggtaacggtc ttcaagtgtc ggggtctcaa ttagtaacaa gaatagggga 30660 tggtttaaca ttcgataatg gggtcatgaa agtaaacgtt gccgggggaa tgagaacttc 30720 tggcggtaga ataattttag atgttaatta tccctttgat gcgagcaata acctgtcctt 30780 aagacgggga ttgggactaa tttataacca atctacaaac tggaacttaa caactgatat 30840 tagtaccgaa aaaggtttaa tgtttagtgg caatcaaata gctcttaatg caggtcaggg 30900 gcttacattt aataatggcc aacttagggt taagttggga gctggactta tttttgattc 30960 aaacaataac attgccttag gcagcagcag caacactcca tacgaccctc tgacactgtg 31020 gacaactcct gacccaccac caaactgcag cctcatacaa gagctagatg caaaactcac 31080 cctgtgctta acaaaaaacg gatctattgt taatggcatt gtaagtttag tgggtgttaa 31140 gggtaatctc ctaaatatcc aaagtactac taccactgta ggagtgcatt tagtgtttga 31200 tgaacaggga agattaatca catcaacccc tactgccctg gttccccaag cttcgtgggg 31260 atatagacaa ggccaatcag tgtctaccaa tactgttacc aatggtctag gttttatgcc 31320 taatgtgagt gcttacccta gaccaaatgc cagtgaggct aaaagccaaa tggtaagtct 31380 cacgtactta cagggagata catctaaacc tataacaatg aaagttgcat ttaatggcat 31440 tacgtcgcta aatggatact ctttaacatt catgtggtca ggtctatcaa actatataaa 31500 tcagcctttc tctacaccat cctgctcctt ttcttacatt acccaagaat aataaagaat 31560 cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca gaaaatttcg aatcattttt 31620 cattcagtag tatagcccca ccaccacata gcttatacag atcaccgtac cttaatcaaa 31680 ctcacagaac cctagtattc aacctgccac ctccctccca acacacagag tacacagtcc 31740 tttctccccg gctggcctta aaaagcatca tatcatgggt aacagacata ttcttaggtg 31800 ttatattcca cacggtttcc tgtcgagcca aacgctcatc agtgatatta ataaactccc 31860 cgggcagctc acttaagttc atgtcgctgt ccagctgctg agccacaggc tgctgtccaa 31920 cttgcggttg cttaacgggc ggcgaaggag aagtccacgc ctacatgggg gtagagtcat 31980 aatcgtgcat caggataggg cggtggtgct gcagcagcgc gcgaataaac tgctgccgcc 32040 gccgctccgt cctgcaggaa tacaacatgg cagtggtctc ctcagcgatg attcgcaccg 32100 cccgcagcat aaggcgcctt gtcctccggg cacagcagcg caccctgatc tcacttaaat 32160 cagcacagta actgcagcac agcaccacaa tattgttcaa aatcccacag tgcaaggcgc 32220 tgtatccaaa gctcatggcg gggaccacag aacccacgtg gccatcatac cacaagcgca 32280 ggtagattaa gtggcgaccc ctcataaaca cgctggacat aaacattacc tcttttggca 32340 tgttgtaatt caccacctcc cggtaccata taaacctctg attaaacatg gcgccatcca 32400 ccaccatcct aaaccagctg gccaaaacct gcccgccggc tatacactgc agggaaccgg 32460 gactggaaca atgacagtgg agagcccagg actcgtaacc atggatcatc atgctcgtca 32520 tgatatcaat gttggcacaa cacaggcaca cgtgcataca cttcctcagg attacaagct 32580 cctcccgcgt tagaaccata tcccagggaa caacccattc ctgaatcagc gtaaatccca 32640 cactgcaggg aagacctcgc acgtaactca cgttgtgcat tgtcaaagtg ttacattcgg 32700 gcagcagcgg atgatcctcc agtatggtag cgcgggtttc tgtctcaaaa ggaggtagac 32760 gatccctact gtacggagtg cgccgagaca accgagatcg tgttggtcgt agtgtcatgc 32820 caaatggaac gccggacgta gtcatatttc ctgaagcaaa accaggtgcg ggcgtgacaa 32880 acagatctgc gtctccggtc tcgccgctta gatcgctctg tgtagtagtt gtagtatatc 32940 cactctctca aagcatccag gcgccccctg gcttcgggtt ctatgtaaac tccttcatgc 33000 gccgctgccc tgataacatc caccaccgca gaataagcca cacccagcca acctacacat 33060 tcgttctgcg agtcacacac gggaggagcg ggaagagctg gaagaaccat gttttttttt 33120 ttattccaaa agattatcca aaacctcaaa atgaagatct attaagtgaa cgcgctcccc 33180 tccggtggcg tggtcaaact ctacagccaa agaacagata atggcatttg taagatgttg 33240 cacaatggct tccaaaaggc aaacggccct cacgtccaag tggacgtaaa ggctaaaccc 33300 ttcagggtga atctcctcta taaacattcc agcaccttca accatgccca aataattctc 33360 atctcgccac cttctcaata tatctctaag caaatcccga atattaagtc cggccattgt 33420 aaaaatctgc tccagagcgc cctccacctt cagcctcaag cagcgaatca tgattgcaaa 33480 aattcaggtt cctcacagac ctgtataaga ttcaaaagcg gaacattaac aaaaataccg 33540 cgatcccgta ggtcccttcg cagggccagc tgaacataat cgtgcaggtc tgcacggacc 33600 agcgcggcca cttccccgcc aggaaccatg acaaaagaac ccacactgat tatgacacgc 33660 atactcggag ctatgctaac cagcgtagcc ccgatgtaag cttgttgcat gggcggcgat 33720 ataaaatgca aggtgctgct caaaaaatca ggcaaagcct cgcgcaaaaa agaaagcaca 33780 tcgtagtcat gctcatgcag ataaaggcag gtaagctccg gaaccaccac agaaaaagac 33840 accatttttc tctcaaacat gtctgcgggt ttctgcataa acacaaaata aaataacaaa 33900 aaaacattta aacattagaa gcctgtctta caacaggaaa aacaaccctt ataagcataa 33960 gacggactac ggccatgccg gcgtgaccgt aaaaaaactg gtcaccgtga ttaaaaagca 34020 ccaccgacag ctcctcggtc atgtccggag tcataatgta agactcggta aacacatcag 34080 gttgattcac atcggtcagt gctaaaaagc gaccgaaata gcccggggga atacataccc 34140 gcaggcgtag agacaacatt acagccccca taggaggtat aacaaaatta ataggagaga 34200 aaaacacata aacacctgaa aaaccctcct gcctaggcaa aatagcaccc tcccgctcca 34260 gaacaacata cagcgcttcc acagcggcag ccataacagt cagccttacc agtaaaaaag 34320 aaaacctatt aaaaaaacac cactcgacac ggcaccagct caatcagtca cagtgtaaaa 34380 aagggccaag tgcagagcga gtatatatag gactaaaaaa tgacgtaacg gttaaagtcc 34440 acaaaaaaca cccagaaaac cgcacgcgaa cctacgccca gaaacgaaag ccaaaaaacc 34500 cacaacttcc tcaaatcgtc acttccgttt tcccacgtta cgtcacttcc cattttaaga 34560 aaactacaat tcccaacaca tacaagttac tccgccctaa aactcacatc cggcgcgccc 34620 ggctcccacg ccgcgcccca cttcctcatc cgcccaaact tacaagcacg ccaaagccac 34680 acctccaccc aatcaaatta cacactacgc ccacttcatt ttaatattgg cactagtcca 34740 gtataaggta tattattaga 34760 <210> 81 <211> 32001 <212> DNA <213> Artificial Sequence <220> <223> Recominant adenovirus genome (AdSyn-CO255) <400> 81 catcatcaat aatatacagt tagcaaaaaa tggcgccttt gtttggcttt gttccaactg 60 tttttggccc gagttgggtt tcgttttccc gggtttcacg tggtgcgtca ggtgatgttg 120 agtttttata catgtttgtg tgtgttttgt gcttgtgtaa aggagttttg gttttttact 180 ttgcggagct tacggactaa tttacttaat ttttggcaaa ttatatctgt ttttgggtat 240 tttgtttgtt atttggtgcg atttttcgac ttttgactca tgtttttctc aggtgttttc 300 cgcgttccgg gtcaaagttg gcgttttatt attaaaccgt attaccgcca tgcattagtt 360 attaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta 420 cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt 480 caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg 540 tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagta 600 cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga 660 ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg 720 tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc 780 caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact 840 ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt 900 gggaggtcta tataagcaga gctggtttag tgaaccgtca gatccgctag cgctaccgga 960 ctcagatctc gagctcaagc ttcgaattct gcagtcgacg gtaccggatc catggtgagc 1020 aagggcgagg agctgttcac cggggtggtg cccatcctgg tcgagctgga cggcgacgta 1080 aacggccaca agttcagcgt gtccggcgag ggcgagggcg atgccaccta cggcaagctg 1140 accctgaagt tcatctgcac caccggcaag ctgcccgtgc cctggcccac cctcgtgacc 1200 accctgacct acggcgtgca gtgcttcagc cgctaccccg accacatgaa gcagcacgac 1260 ttcttcaagt ccgccatgcc cgaaggctac gtccaggagc gcaccatctt cttcaaggac 1320 gacggcaact acaagacccg cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc 1380 atcgagctga agggcatcga cttcaaggag gacggcaaca tcctggggca caagctggag 1440 tacaactaca acagccacaa cgtctatatc atggccgaca agcagaagaa cggcatcaag 1500 gtgaacttca agatccgcca caacatcgag gacggcagcg tgcagctcgc cgaccactac 1560 cagcagaaca cccccatcgg cgacggcccc gtgctgctgc ccgacaacca ctacctgagc 1620 acccagtccg ccctgagcaa agaccccaac gagaagcgcg atcacatggt cctgctggag 1680 ttcgtgaccg ccgccgggat cactctcggc atggacgagc tgtacaagta aagcgactct 1740 agatcataat cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac 1800 acctccccct gaacctgaaa cataaaatga atgcaattgt tgttgttaac ttgtttattg 1860 cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt 1920 tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtaagttta aacggcgcgc 1980 ctgaaatgtg tgggcgtggc ttaagggtgg gaaagaatat ataaggtggg ggtcttatgt 2040 agttttgtat ctgttttgca gcagccgccg ccgccttaat gcgacggtgg gccgctactt 2100 ctcggctgtt gcacgaagat ccgcctgcga caccgcccag ccaagaccaa caggctgaag 2160 tacttcgaag agatattcac attctgaatg cgaaaatttc tgagttggaa aatcaaatgg 2220 aacgtctgtg ccgctctttg gaatcgacct ttaacagaat agaactgctt cattctatgc 2280 ttgcacaagg agaggaagag gaggaagagg aggacggagc tgaagacatt gaggaaaacg 2340 gggaagaaag tgattaaaac ataaataaaa aaccagactc tgtttggatt tggatcaagc 2400 aaaatgcaca cacgcttatg cttaataaag gtgtttatta cttatttgcg agtttgtcac 2460 attttttact atatgcggtg ttccaccttt gtcgctgacg aaggactttg tctatttttt 2520 ctagtagctg gtaaagaata gtttgcacat ttaggtacat aggcattaaa ccgttttggg 2580 ggtgaaggta catccattgc atacattcat gttcggggga ggtgttatag atgatccagt 2640 cgtaatttat gtggttagcg ttatgatgaa aaatatcttt tagcaaaagg gtaatagcag 2700 taggcatggc tttagtgtag gtgttaatga agcgagcaac ttgggaaggt tgcattttgg 2760 ggctaatgat gtggcatttg ctttggattt ttaaagtagc aatgttgccc gcctggtctt 2820 ttctggggtt catgttgtgc agcactacga aaacagagta accggtacac tggggaaaac 2880 gatcgtgtag ctttgaagga aaggcatgga aaaattttgc aatgctttta tgttttccca 2940 attcctccat acactcatcc acaataatac aaatgggacc tctttgggcc gcttgggcaa 3000 aaatgttttg ggggtgtgta acatcgtagt tgtggtctgc tgtaaggtca tcgtaggtga 3060 gtgtaatgag tcgaggtttt aaagttccgc ttttaggaac aatggtctgt tgcggaccgc 3120 atgtatagtt tccttcaact agttgtgcat tccacgctga catttcttgc gggggtatca 3180 tgtcgatttg aggaaccaca aaaaaaacgg tttcgggtga aggatctatt aaatgacagg 3240 aaagaaggtt gcggagcaat tgcgactttc cgcttcctgt gggcccgtac acaattgcaa 3300 tcaggggttg caaagaatag tttaacgatt cgcagttgcc ttctggactt aaaagcggag 3360 ctgcactatt tagcgattta cataggatct cataatcatg ttttagttct tgaaggagac 3420 ctttgcctgc taaggccgct aagtcttcaa cagtctcaaa gttcatgagg ggctttagtc 3480 cttcggaaag gggcaagttg gatagagtgt gctgcaggca ctggaggcga ggccaaagga 3540 attgcagttc ctcgcctaca aggcaatcca ggttgtttcc ctgttccggg gattggggtg 3600 ggcagtggag tatggaatta gacgaccgtc ctccaggaga gctaaagttg ggttctgcca 3660 cgggcgaaga gagcgagtca gcactgtctc cgttacggtg aaagccgatt cttgcttgtt 3720 catgttcacc aaggttctct ttagactctg tcgggaagtg tagaagttgg ggtcagattc 3780 attaagacgg tatgcttcgt agcacgctag taagatgtcg taggataacg aagcaacagc 3840 atgacccttg gcccggagtt ttccagctcc ttcttgacca caggttgggc acactaattt 3900 ctgtaaggcg tagagttttg gagcaagaaa aaccgttcgg ggactaaatg catcgctccc 3960 gcagtattta cactgagttt cacattccac tagccatgta agactcggct tttcagggtt 4020 aaaaacgagc ttacctccgt tcttcttaag acggtgtttt ccccgggatt ccatgaggtt 4080 tcgccccgct tcggtgacaa acaggctatc agtgtcaccg tacacacttt ttataagtcg 4140 tttttcaagt tgaagacctc ggtcactttc gtagagtatg tcactccact cactcataaa 4200 cccacgagtc caagcgagca caaaagaggc aaggtgtgag gcgtagcggt cattgtcgac 4260 gagtggattg ctgtgctcta gagtgacgag agtcaggtcg tcggcttctg catcaagaaa 4320 tttgattggc ttaaaattaa aaagggcgtg gtcaacaact tgttgttctc tataaaaagg 4380 ggcggggtgg gagcctcgag gtgatagttc ggcggaatct gcgacgtgcg gaggccttgt 4440 gttctcacaa gaaggttggt atatggtttt aaactcggtt aaaatttccg cacacaaatt 4500 gtccgtttca actacatgca aggccttaat tttttgtcgg cctgtacaaa tttctttaat 4560 ggttcctgga tataattgtg atgcaaaaac agtgcttttg ttatcttgac gtgttgcgaa 4620 tgacccgtac agggcattac tcaggagttt tgcaatgctt ctcatgacca tgtttttttg 4680 tcggtcggct ttttcttttg ctgtaatgtt tatggttaca tattttctta caaggcattt 4740 catgtgcgga aacaaagtag tcagggcttc gggcaagatg ttaactttcc aaccccgatt 4800 gtgaagtgtg ataacatcaa tagtggtggt aatttctcct cgtagcggtt cgtttgtcca 4860 gcacagtctg cccccttttc gactgcaaaa agggggtaaa acatctaatt gtgtttcaca 4920 cggcggatca gcatctataa gaactatacc atgcaacaaa caagtgttaa agtagcttat 4980 aggggcactg tttgataagt gctttgtcca gtcagctaaa gcctctgcgc gggcctttgg 5040 ctccagcggc caaccagaag gcattggatg ggtaagtgcg gaagcataca tgccacaaat 5100 gtcatataca taaatcggtt ctttcaattc tcccaggacg gtaggataac atcgaccgcc 5160 gcgtatgctt tggcgtacaa aatcatacat ctccctagaa ggggccagca acacatcatc 5220 aaagttgggt ttttccggtc tgagttcgga ataaagagtc tgtttaaaga tggcgtggga 5280 gttagcgctt attgtaggtc gctgaaaaat attgaatagg catttgggca gtcctactgc 5340 attttgaata aaatgatgat aagagtctaa tagtttgcag actagtttgg tggttactgt 5400 aacatcttgt atgcagtatt ttaatgtatg ttctataagg ttgtacttga tgggacacac 5460 acgatcggga caacgttttc ttagctcttc tttttctttt ttccattctt gtaatccctc 5520 ttcatattca gcttcgctgt tccaatattt tctgtgggga aaaccatcaa atatatttat 5580 tgtgtcgtac cgtccagtca tgtaaaagtc atttacggcc gcataggggc aaacgccttt 5640 ttccaggggc aaagaatagg cctcggcagc tttacgaaga gaggtgtggg tcaaagcgaa 5700 tgtgtctcgc accatgaact ttacatattg aatcttagag tcactggtcg tgagacagcc 5760 ttgttcccac tgttcaaagt ctgttctttt tttatagcga ggattgggca gtgaaaaagt 5820 aatgtcatta aacagaatac ggccatttcg aggcatgaag tgacggtgga ctcgcagggg 5880 aggtggaaag ttcactctgt tgtttaggac ttgagccgcc actacaattt catcaaaacc 5940 attaatgttg tgacctacta catagacttc aataaacttg ggagtgtttt ttaaaggcgg 6000 agcttcttgt tccagtcttt caggggttaa gtctagcaat cccaaaggaa gagagtcgat 6060 gtaagtttgt agttctggat aaatattgtt ttgccataat tcctctgcaa atgcttcttg 6120 gagacgatcg cgaaatcgac gaaactgtct tccaattgct tctttttggg gattaattga 6180 ccacagtatg tagggacgta ggtggtgttc tgaataaccc atttgtttgg caattgagtg 6240 agcttttgca caaagaaaca tatcaccgta gagttccata actagcatga agggaaccaa 6300 ctgctttccg caactgccat gccagcaata agtttctagg tcataaataa tgaagagccg 6360 ttttgtggta ggtattgaac caagaggggt aaagctgatt tttgtccacc actggcgact 6420 aaggggtttt aggttgtgaa aaaaaaagga acgtcgtcgg gcattgcagg tatgtttgaa 6480 gcgaaaaaaa ctaccacagt cttcacatcg ttgacaggga tgcatggtat ctacaaggta 6540 caagccaatt ttgtggtagt tacttccttt ggttccaagt cccttttgaa tatgtaaaaa 6600 tgtcagttcg ggtctgtaat tttgccaaca ccaacgcttt tcttcgtatg aagcgtcttt 6660 atccacctgt gggtagcgtc cggcatggcc ttttaaacca ggccatttgc tttgacgaat 6720 gtacagacca tcataccata catagtttac aggagcaggc cactcttctt tttgtaacag 6780 tcgcgttaaa gaagttacag aaatactttt gtgtccaatg tctgcagctt taaaagcgtc 6840 taataagaaa ggatgcggaa aaggaccgca tcgttgaaga cataacaaat tagtaaaagg 6900 tacaacatag gatgtaaaat agccaatgac catatgatca ccgcgcggac atgccgctcg 6960 gagggttttg tgagcttttt gcagaacttt actctgttgc ttctgttttg gggaacttac 7020 agtcgccttc tttcggggac gtcctcgggc gggagtacgt gagcttgatt gtgcatcggc 7080 atcgggcgtc gttgttgacg aagacgagtc gcctcctgtg atactcgacg ggttaaggtt 7140 tgtatccgtt gatttcctgt gaataccact ggacccgaaa gccggaacct gaaagaaagt 7200 tccatactgt caatatcatt gtcattagcc tcaatttgtt gtaaaatgtc tgttatatcc 7260 ccactatctt cgggatggtc gatggcgtcc atgagatgtt ctatttctcc ttgttcaata 7320 ttttgacgac cggcgtgagg aatggaagct gttagttctc tgactaaccg ctgcataact 7380 gctgtcattg agtcatagcc taattcacta aaaactctgc taaaaacaag tgttccttgc 7440 acgtccctgg ctcgcaggat gatttgactc agttccaaat taagatgtct ttgtgccatt 7500 agtctatggt ttaactgata atgaagataa tttagtgtgg tggctacgtg ttctgttgta 7560 aaaaagtaca tgatccatcg gtgtaaagat gcctcattta tcatatcttc gtctattaga 7620 ttttctaagg tagcgtaaaa acggagtgca aaagtaaaaa agttttgttg tcgcgcatgg 7680 tcggttagtt cttcttgaag aatttctatg ctctcttgaa cagcagcgcg aatagcttgc 7740 acaaagtcca ccgcttcttc ctcttcatca tcctgtaagg gcgaaggagg agatggtggg 7800 ggtctgggcc gtcttctacg agtaggaatg ggaaggcttt caataaagtt aacaacagct 7860 tctccgcgtc gacgcagcat tgaggcggtt actgcacgac catcttctct aggtcttaga 7920 atagcccctc ctgcaaggag accggcgggt ggcaaggacg gggaaggaga gggaagacta 7980 agacagtcca tcagtaacgg caaaatctgt ctcaatggta ggtgccctaa aagctccgac 8040 agatcgactt gatcatttga gtaaaactca aaccaagaag acaaccagtt ttgcgaattt 8100 acaggtaagg accaaagagt acgtgcaaaa gcatctgggg ggaggtcggt ttcaggagcc 8160 aatgttaggg catgaagcaa aaataaaaaa tacgccgagc ggatgcgcgc tatgagagac 8220 aagagcgtgg cggcattttc tgcgctctgt ccctcctctt ccggaggctg tgcgggcggc 8280 ggcgaacggc aaaattgcgc aaagccccaa gatgacggtt ggcagtgtcg catgaggtgg 8340 cgaagcggta ctggaacggg gctgttacca tctggcaatc ccagtccttc cattcttgct 8400 cgatgctgta gtccaaaatc ggcaatgatt cggtctgcta gaatacttcg ttgtatggct 8460 aaaaaccgtt ctcccatgtc tgcatcctca tcatccacat ttaaaaatct tctgtacgca 8520 cttatattaa tggtataaga ggctgttgct aggcagagcc agtcgagcag ttgaataccc 8580 tgccgtctag tttccaagta cgttattcga ctgtacgttc gagtgtcaaa ttcataatca 8640 ttgaaggcgc gaaccacgta ctcgtagcca acaagaaagt gaggaggggg ataggagtac 8700 aacggccagt ggcgcgtggc tggggcccgc ggcgctagat ctaacagcat cagttgaggg 8760 taattgtaga caaagcgact aagccaagtt acgcctggcg cgctgacggc caccggtggt 8820 aatgctccga tacgattcca tatgtttctc agggggcgga acacttccat cgtgtagatt 8880 cgctgaccgg ttaggcgagc acaatccagt ggcgactgca aacacacaag tatattcacg 8940 tcgccagcgt atttagacat gcatcctgtt ctgcgtcaaa tgctgccctc taaacaaccg 9000 gggccatcta cgccttctga tcctgcctgg attccacccg aaggggaggg aattgcaaga 9060 caactacctg ccactgcagc agagggagga cgggatcccg ttgcctgtca tcctcgagtt 9120 cagctgcaac aggacatgtc tgagagtttt gtaccagcac agaacgtact tagggaagac 9180 cacagtcagg gacgggggga accagagggt tcccgacatt tgcgatttca agccggacaa 9240 catttgcatc ttaatccgga cactgtgctg agtggtaaag actttgaccc tagtgaagaa 9300 agcatggccg caggccctgc tcttagtaag ggtcatgccc acgttagggc agcagatttg 9360 ctaacagctt acgagcagac ggtgcgtcaa gaacaaaatt ttcaacaaac atttaataat 9420 actattcgtt gtttacttgc aagagaggaa acaacatggg gattgatgca cctgtgggat 9480 tttgctcagg ctttacaaag gggaccggaa agtcctgcct tgcgcgcaca actgtttttg 9540 gtggcccagc attgtagaga cgagggagtg tttagggaaa gtattttaaa tcttggtgct 9600 tctgaaagta gatggctgct ggacttaatt aatttacttc aaagcattgt agtgcaagaa 9660 aggcggctag ctttggaaga caaagtcgca gcaattaatt atgctgttct tagtttggga 9720 aagcactatg ctagaaaaat ctttcgcact gcttttgttc ctgttgataa ggagctaaag 9780 ataactacat tctatatgag gatggtaaag aaagcattgg ttctggctca agaactaggg 9840 gtgtatcgca acgttcgtct gcaaagagtg gtcagtgctc aaagaaaaaa ggaaatgagt 9900 gatcaggagt taatgcagca gctgcgatgg gccctcacag acagaagtga agaagaaaaa 9960 acgctggctt taccggctgc ggagtcggaa gacgaggagg aaggggaacg ggagtggagc 10020 tcggatttta ctttttaagt gctctgtgtt tttatataga gacgacccat ggctgcctta 10080 tcacctactg tcagggcggc tctgcaaagc caagcggctg gggaagaacc ttgggaacag 10140 cgctttaagc gtattatgag cactactctg aagaaccctg gcgcttttcg cagtcaaccg 10200 tggtttacta gacgagatgc aattctggag gctgtgttgc cttcacgtac agatccaacg 10260 cacgaaaagg ttctagcggt agttaatggt ttagttcagg caaaggcagt aagggcggat 10320 gaaggaggag ctatttacga tgccctactg cagcgtgtgg gtcgctataa cagcagtaat 10380 gtacaaagca atctagatca tttagttcag gacgtaaggg aagctgtagc tatgaaagct 10440 caagaggaac gcggatctat gggttctttg gttgccttga atggtttttt gagcactttg 10500 cccagcacag ttaatcatgg tcaaagtgac tatgtggggt ttgtgggggc gctccgtcag 10560 ctaattgcag aggtacccca aacattagtg tatagaacgg gaccatttta ttactttcaa 10620 acgagtagac aaggccttca gacagtaaat ttaacaaaag cgtttcagaa cttgtcggcc 10680 ctttggggag taacgacttc tgcccaaaca ccaatggcaa cagccgctct tttaactccc 10740 aacacacgcc tgctgcttct tcttgtagcg ccttttacag actcgcgaac agttaatggg 10800 gacacatact tggggcactt attaactctt tatcgtgaag cgttgcgaga tgctcgccta 10860 gatgaaatca cttactccga aattagagat gttgcaaggg caaccggaca agatgacagt 10920 cgtgctttac aaagcacctt aaattttttg gttagtcaac aaaccaaacg tcttccagag 10980 gatgtgttcc tcacccctca acagactacg gtgctgcgct acttgcaaaa agccatagag 11040 cttcagcatg ctcgagaacc ccatgaacga gccgaccgac tgcttgacgc agtagtagcc 11100 gatctggagc cttcatttta cagcaagcac aggcacttta ttacaaagct gttagattat 11160 tttcagcgtg cggccgctct taatcctcac tactttatga gcattgttaa aaataagcac 11220 tggacccctc cgcctggctt ttacactggg gactttgaac ttcctgaagt ggtccacgac 11280 agttttcagt gggatgacac cgaagacggg gcttggagcc gccctctcgc cgaacaagtc 11340 aatgaagaag aacccaacac tgactatctg gcagagtatc ggagtgcgtt tagtgacaat 11400 agagaggaaa aaaatcaaaa aaaagagtgg gagagtcttg tggacatgat ggctcgttgg 11460 aaaactcatc gtcaaagcgc cctcgattta gatgatgaaa tagaggaact ttcgtccacg 11520 aatcctttta aacatctaca gccccaattt tgaagcagtg tataacttac tatttgcgcc 11580 atgtggcagc ttgtagacgc agaatgagtc gctacggaaa tgctccgccc ccctacgagg 11640 aggtggtctc tgttgcgacg ccttcttacg ttcagcaacc gtgggtaccc ccgaggtact 11700 ttgcgcctac ggaaggaaga aacagcatcg tttacgatca gtttcccact tgctacgaca 11760 ccactaagct cttcctcgtg gacaataaaa gcgctgacat taccgatctc aacatgcaaa 11820 acgaccacag ccattttgcc accaccgttg ttcaaaatag cgaatttacg ccccgcgaag 11880 caagtaccca acatataaca ctggacaacc gttcccgttg gggtgctaag cttaagactc 11940 tgattcaaac aaacttaccc tcagtaacag actatatgta caccaactcg ctgagggtta 12000 agttgatgga atcctatgac gaagccaccg gaacagccac gtacgagtgg cacgatatta 12060 cccttcccga aggcaacttc gacagtggtc gaattattga cctgttaaac aatgcaattt 12120 gggagttata tcttacttac ggcagacaaa atggcgtcag agaagatcaa ataggcatta 12180 agtttgatac gcgcaatttt cgcttgggtt ttgatccgct aacaaatctt atcatgccgg 12240 gtcattacac ctatgagtat tttcacccag acattgtgct catgaaaggc tgcgcggtgg 12300 actttagtaa aacgcgctta aataatgtat taggttggag aaagcgctac ccgtatcagc 12360 ctggatttgt tatcacgtat gatgaccttg tgggaggaga catccctccc ttgttagatt 12420 tggctgcata ccttaagaag ccgagagagg gagccggagg accaattatt agagcgttgc 12480 aaaaagacag taagggtcgc tcgtatcacg tccagtacac tgacctggga gaagtgacgg 12540 ggtaccgcag cttatatctt gcgtacaatt acaccagtga cgtcacacac ttgcgtaagt 12600 ctacagtgcg ctcttggctg gttcttacgg cgccggatat aacaggcggg gctcaacagt 12660 tgtattggag tttgcctgac atggctttgg caccgactac gtttcgtccg agtggtcaga 12720 ctcccgccac tttcccggtg gtttccactg agccgttgcc tattgccgcc agaactattt 12780 ttaacgctca acccggatat gctcaaattg taaatcaaaa cactagccaa acaatggtct 12840 acaaccggtt ccctgaaaac gctatcctta tgcggcctcc ccaaccgttt atggtccaag 12900 tgccagaaaa tgtaacaacg gtgaccgacc acggtactct tcccttacaa aatactttgt 12960 ctggtgttca gcgagttgct gtaacggata gtcgccgccg cacttgtcct tatgtgtata 13020 aatgcgctgc aacgttagaa ccacacatca tgagcagtcg tacactgcaa taaagttgaa 13080 agcaaagcaa acgtcgtttt ttggcacgta cttttttacc ctctggtcat gtcctgtccc 13140 tgtttgttac agctgaccaa taagcaaata tgagtatttt gatctcgccc agcgacaaca 13200 ccggttgggg cttggggacg ggtaaaatgt acggcggtgc tcgcaagcgc tctgccgagc 13260 atcccgttca cgtgcggtct tattggcgag ccgcgtgggg cagtcgaaac cggcgacggg 13320 ttgccactgt tgccgcggaa gatgctgaag cacctcagct agaagacgtg gcacaagctc 13380 ccgcaacagt cccaattgtt aggaggcata ggagaagagt agggggtagt gcgcgcacac 13440 gaggtcttcg aaaaagtgcc cgcgtgcgtg cagctgcgcg tgccattgtt cgagcagtta 13500 atggagcggc tgcagccgca gctccaactg tgcccgcctc tgcaaacttt gctgcaatgg 13560 ttggtgctat agcaaatgcg cgggctgcat atcgccaccg ccggtctcga gcaggaatca 13620 accccgttcc tgcgtctcgg tcaacaacca gagtgcgact gccccgcact gttcgttttc 13680 acccaagtat gggtgctttt cacaggcgct ggtggcggat tcacacaagg ggacgtagaa 13740 aggcctctgt gcgtcgtcgt cgtacttagt ctagaacttg ctatttttaa gtttatcctc 13800 tcgactacat ggaagactcc cgcgtgtact tggatcgctc caatgcaact ccgtcctata 13860 tcccggtcac tccacaaatt ccggtgccgg gtttgggcca tagacgtgta aaacgagaac 13920 acgtacaagt ggatgaagaa ccaactgtgc agatactgat aaaaagacca aaagttgagg 13980 acgaggaagt tcctattcct atttttcctc ctctgcctcc tgcacgagat cccgtggcag 14040 ctgtggcagc cgcaggaggt cagattgtaa gacgcagacg ccggcgggtg cctggcactg 14100 caatgggagt tgacacagta gacgtggtcc ttccagtagg agtgcgatac catcctagta 14160 ttgaggcagc taggccaccg gcagtcccgc cccctcgtgc agttcctccc gtaggggtgc 14220 gctaccaccc aagtattgag gtagctagac caccggcggc tcggattagt cctcctaggc 14280 gtcgccgccg tcgacgtaga tcccctcgtc ctcgcgctac agcagcgtat cgatcgtctg 14340 cagaagtagt agaaagaaga agacgggtgg cacaaacagt accggttgta cgttatcacc 14400 cctccataca agtggaacca gctgttcatc ctcccctagc tcctagactc cctgttcaaa 14460 tggcttacac gcgctaccat cccaccatac actaagtact cgtgccgtca ttgttgccgt 14520 ttcagccgcc atgccagctt atggtctgac gtatcgcttt cgtttccccg tggcactacg 14580 cagacgtcgg aggtctcgtt tcagcggggg tagcctatat gcacgacgta ggcgacgccg 14640 agttcgtgtt aaaggagggt ttttgcctgc cctcattcct ctaggcgcag ccttgatttc 14700 agccataccg gggatcgcct cagtagctat gcaagcaagt caacttaaaa aataaaaagt 14760 aaagagtcat cacagggcaa aattttcctt ttacttcttt aactttttta gtgccatgga 14820 cgacccattc tccactctcg cgccccggcg gggcacacaa cctctactaa gcaactgggc 14880 aaccattggc atcagcgagc tacacggtgg agctttgggg tggggtagtt ggtggagtaa 14940 cttatctcgt ttgggcagta gcttcggcag caatttaaaa aacttgggtc taaaagcttg 15000 gaacagtagt acaggacaag cactgcgtca gcatcttaaa gataccaatt tacaacacaa 15060 ggtggtagag gggctttcaa caggcattca cggggcagta gacatagctc ggcaggaagt 15120 ggacagacag ttggccaagc gactggaaaa ctacgaacca ccgcgagtgg cgtccaccga 15180 agaaacagtg gatgatgtaa aaaccgtggc tttgccctcc aaagaagacg agtccgaaag 15240 agtactggtg acaaagattc gtgagcctcc accgccttac gatgctgtgt ttggtcccgc 15300 gccatctgcg gaaactaata agaagcaaaa gttcgaggaa accctgcaaa atgccggtct 15360 ggtttcttct ccaccggccc ccatagccgc gcccgcagcc atagccgttc ccgcacaaac 15420 aacgatgtcg cacccggcgt ctagccgtcg ccggcatcat tggcaaggaa ctctggacag 15480 cataatgggc ctgggtttac aacctatcaa acgccggcgc tgtttttaaa tgttctaagt 15540 tgcttacttt ttgttagcgg acacaagatc attcgtattg ctcgcacttc actaggactc 15600 tgagcggtgt ccgccatgac gacgccttca atgcagcccc agtgggcctt catgcacatc 15660 gcgggacagg acgcttccca atacctgtca ccaggggtgg tgcagtttgc agcggccaca 15720 gatacgtact tttctctcgg aaacaagttt cgcaatccaa ctgtggcccc cacccatgac 15780 gttacgacag accggtctca aagactcaca ctgcgtatag tcccggtgga cagagaagac 15840 agccagtaca cctacaaaac caggtttcaa ctttctgttg gggataaccg agttctggac 15900 atggccagca cttactttga cattcgcggc cgcctcgaca gaggccccag ctttaaaccc 15960 tactcaggaa cggcgtataa cagcctggcg ccgcgagctg ctccgaataa tttaatgttt 16020 aaaacaggag cagacagcaa aactatgacc atagctcagg ccaacattgt cggctcgacc 16080 atagatcaag acggtttaaa aataaacaac gtagccctga acccgaatgc tggtgagccg 16140 gcagtgcagg aaggtttgga aaattggatg gaagaattac aaattggtgc tgacaaaaaa 16200 tttgccagcc gcgttcttaa agccgaccaa cctgtgctgc ccaactacgg aagttatgct 16260 tatcccacaa acatcaacgg cacccaaaca aaagacggca ccacagtaga caaagtgtac 16320 atgtgctcca aaggagcaaa tgtacaaaac ccagacgtcg tgctgtacag cgaagaggtg 16380 aatttgcaag ctccggacac acatctgcta gatggtcccg gtgctgacaa ccccaaagac 16440 agagtggctt tttgcgctgc tcccaaccga ccaaattaca tcggttttag agataatttt 16500 atcggcctga tgtactataa tagcaatggc aaccagggag tgttggcggg acaggcttca 16560 cagctcaatg ctgttgtaga tttacaggac agaaatactg agctgagtta ccagtttctt 16620 ttggattcgc tctatgaccg gagtcggtac ttttcattgt ggaaccaagc aatagatagc 16680 tacgatcccc gggtacgcat tattgaaaat gacggtgtag aggacgacat cacctctttt 16740 gcttttgacc ttcggggaat aggcgatcta ccgtacaaac aggtgcaaac tcacaatgga 16800 aaccaacagt cggccaacac taccgacact tgttacattg gaaagggaaa catggctgcc 16860 atggagataa acattccagc caacttatgg ctcggctttt tgtacgccaa tgtggctcag 16920 tatatgccgg acgactttaa agtggacccg tcgaacattc aaatgccaca ggacaaaacc 16980 acgtacgctt acatgaacca aagaattgct cctgccgggc ttatagaaac ctacgtaaac 17040 gtaggcgggc gttggtcagt tgacttcatg gacacggtca atcccttcaa tcatcaccga 17100 aatgaagggc taaagtaccg gtcccagata ttaggaaatg ggcggtttgt agactttcac 17160 attcaagtgc ctcaaaaatt ttttgctatc aaaagtttgc ttttgctccc cggcagttac 17220 acctatgagt ggagctttcg caaagacgta aacatggtct tgcaaagctc cttaggtaat 17280 gatctcagag ctgacggcgc aaggctcgag attcacagtg tgaatcttta cgccagtttt 17340 ttccccatgg cgcacaatac agcatcaact cttgaagcga tgctgcgtaa tgaaacaaat 17400 gaccagactt ttttggacta cctgagcagc gcaacgatga tgtttcccat tcctgcaggt 17460 caaacccaag tgccagtatc aattccagcc agaaactggg cagcctttag gggttggagc 17520 tttactcgta ttaaacaaca agaaacgccc aacataggct caccgtatga cccgtacttt 17580 aagtacagcg gaagcatacc tttcttggat gctacttttt acctaacaca cacctttcag 17640 cgagtttcaa ttatgtttga ctcttcagta agttggccag gaaacgaccg acttctaact 17700 ccaaacgagt ttgaaataaa acgtcacatt gacgctgaag gactatgtgt gggtcaaagt 17760 aacatgacta aggactggtt tttggtgcaa atgctgtcca actacaacat cggatatcag 17820 ggcttttatt taccagaaaa caacaaagac agaacatact cttttgttcg aaactttgaa 17880 cccctggccc ggcaagtggt ggatgatgct gctgcggcta actatcgaga cgttcctctt 17940 tccaaaagat ttaacaattc gggttggaga agcgccggtc ctccaatatt tgctcgagag 18000 ggggcgcctt atcctgctaa ctggccctat ccactgtgtg gagaggcggc atgggctgca 18060 aaaacccaaa gaaaatttct agttgaccgg tacatgtacc gcattccctt ttctagcaac 18120 tttatgtcaa tgggcgcttt aacggacctg ggacagaatt tgctatacgc aaattccgcc 18180 cattctttgg aaatgacttt taatgtggac cccatgcaag aagccacttt tctgtacatt 18240 ttgtttgaag tctttgactg tgttcgcatc caccaaccgc acaggggcat catagaggca 18300 gtgtacctgc gctccccgtt ttcagccggc aacgcaacca cctaatcgta tgggttcgtc 18360 tgaaacagag ctccgtcaac tggtcgctga ccttggaata ggttcttttt taggtatttt 18420 tgataaacac ttccccggct ttataagtgt taacaaaccg gcttgtgcta tcgttaatac 18480 agcaagtcga gaaactggag gggtacactg gctagctatg gcttggtatc ctacctcttc 18540 cactttttac ttgtttgatc cgtttggatt ttcggatcgt aaactgcaac aagtgtataa 18600 gttcgagtac gaacggcttc tcaaacgatc agctgttagc agctctagca gcaagtgtgt 18660 aacactagta aaaagccacc aaaccgtcca ggggcctcat agcgcagcgt gtggactctt 18720 ttgtgttcta tttttagcag ctttcggaaa gtatccacaa aaccccatga acaataaccc 18780 aatcatggga ccgattgagg gagttcctaa cgatcaaatg tttaatccct gctatactaa 18840 aaccttgtac cgtaatcaac aatgggtata ttcttactta aataagaact cgctttattt 18900 taggctacat gtagaactta ttaaaaaaaa tacagcgttt gacaaattgt tagtgcgcaa 18960 atgactttat tgtaattgtt ggtatattgt aagtattggc attcacaatc attaaaggga 19020 aagcaaaatc gttttgttgc cttgacctcg tacttaaact ttcgccgtta caaaaagttg 19080 aacatcgcca tctccggcac cttggggcag cacagtggag tggaaacaca atgttggatc 19140 ccacttaaat tcaggcacaa aaagggaagg gggttgatcc aagagttttt ggatcatttt 19200 tttagcgagt tgcgccgccg tcaccacatc cacagagctg attttccact cacagctttt 19260 tccaacggtg ccttttccag ccttaccaaa ggtaacattg cagcactggt acacaagtac 19320 cacgggattc tcaacactag cccttgcaac gggatctaga gcggtagcat ccagcccttc 19380 agccaaagat aaagcatagg gagtcacgcg gcatgtttgg cgacccaaaa taggttgagc 19440 caaaccaaag ttacactcac aacggaggca cagcaacatt ctttctccca cccccggggc 19500 ttggggatac agtgcctgtt gaaaggcaat tgcttgctta aaacccttta gtgccttttt 19560 ggcatcggta aaacaaaaac cacacgactt attggttggt tgattaaagg ctacagaagc 19620 atccatggca cacacaactg cgtcataggt tacacgcacc actgaacgac cccagcgatt 19680 agtttgaaca caagcagcgc tcccttgttc cttcaaagcc ctctgcccac cctccgtagt 19740 cacatctaac tcaacttgat gatccttggg agacatagca gtgccgtgta aacagtgaag 19800 cgtagtagaa cagttgtgct tccacgccgc cacaccggta acattaccca aggtatgggc 19860 agcaaaatcc acaggcgaaa tgcctgccgc ttgcagaagc atggcaaaaa caaaacgccc 19920 catttgcatg gtaaaggaac gcaacgtgga aaaggttaaa ctaggaacta atttttgttg 19980 caaaagccag ctatggctca gcttcctaaa tagctcagcg gtttgagcat tgggcaagaa 20040 ggtacactgc ttgccatcaa cttttaacac caaacacatc ttgtgcaata gctctctagc 20100 tgtttgccaa cacgcttcct cttcttctgc gacgcctgct tcagtaaaca ccacgtcgtc 20160 ctcatccgag gattcaaatc gtggagggac ctccgtctgg ggctcaggtt ccatgttcac 20220 atcttcactg cctctgtcgc caccggaaac atttgcaaat ttccctgaaa cagcaggagc 20280 aagcggggaa ctgcgcgggc caagagcagc tcggctcttt ttaccgcagt gggccgtaga 20340 cgcctcgcca acagcagagc gcttaacccc gccacgcttg gtttcataaa cctgctgttg 20400 aggggtgcgc tgtggtggta caggtcgcga gcagctcatc gtcctcgtct gattctttgc 20460 tctacagaat acaaaagcaa tgcagtcaaa cacccaggaa agtgagacaa ccgaggtgcc 20520 agatacaaat ccaactccgt tagaggaaga aacaagcaaa agcgacacac atgaagcgac 20580 aaacgacagc aactacttgt ccgcggactc gcttcttgtt cacatccagc gccaagcgcg 20640 tatcctacgc gaggccctac agcccgagca agacaaaaca gaatggtctg ccacaaccct 20700 gtctcatatg ctggaaagag agctgtttac ccgctccaac gcaaaatttc ccgcagttcc 20760 caagcaaagc aatggctcaa tgagcccaga ccctcgtctc aatttttatc cggcatttat 20820 ggtgcccgag gctctggcta cctatcaccc ttttttcgta aatcagcgga ttcctctaag 20880 ttgcagagct aaccgcccct tggcagacaa gaattgggag ctgaaagatg gaagcaggct 20940 gcccgacatt gttaccgtgc aagaacaacc gcgatttttc gaaagcctgc aaggccagga 21000 attgagccga aaccaacttg aagtggcagg cagcgacagc gagaccgggg ttttaactga 21060 actggagggg gacagccccc gccttgctgt ggtaaagcgc tgcctgagtg tgacgcatgc 21120 tgcctatccc gccctcggtt tgccgccaaa agtttccaaa attatgtcag aggaattgac 21180 cttcaaaaca aatttagaaa ctggagacaa cagtcaaccg gtggtcagcg acgaacaatt 21240 acaaaaatgg ctcaaggcca aagatcctgc cgatcccgcc atagaggaac atcgcaaacg 21300 ggtcatggcc gtgaccttaa ttacgtgcca gctggaagca ctgcgttctt ttttttcgcg 21360 cgcagatgtt atccgccgtg taggggaaag tctccactac ttgttccaac acggttacgt 21420 caaacaagcc atacaagtgt gccaaaccga tttaacgcat ttggtcacgt acatgggaat 21480 tgtgcatgag aacagactag gccaaacagt cctacacggg tcattgctgg gggaagcgcg 21540 aagagactat atacgggata ctgtttattt gttcctaatt tatacttggc aaacggccat 21600 gggtgtatgg caacagtgct tagaagacga aaatttagaa aagctcagaa aaatcttgca 21660 gtctcatcgc cgctctctgt acacagaaac aaatgagcgc cttcttgccg ctgaactgcg 21720 ccgtctggtg tttcctgccc acctggaaaa tactttggcg caaggtcttc cagacatctt 21780 gcaccagagc attattaaca attttcgttc gtttatttta gaacgtagtg gtattttgcc 21840 ggccaccaca tgtgcctacc cttccgattt tgttcccact acattcaaag agtgtcctcc 21900 tcctttatgg gctcacactt atttgcttac tttagcaaac tatttcatgt atcacaacga 21960 cttgcaagaa gacctaacag gcgcgggact gttgagcgct cactgccgct gcaacttgtg 22020 cagtccccac cgcagcctgg tccacaacac tgctttactc aatgaagtaa aatgcattaa 22080 tacctttgag ttgcagggac ctcctggaaa agacggtaaa agtgggccct gttttaaatt 22140 aacacctggc ttgtgggtgt ctgcctactt acgtaagttt gaggaacagg attaccatcc 22200 ttatagtatt acctactttg aaaattcaaa aaagcaacag cctaagaccc ctcttagcgc 22260 atgtgttctt acgcagacag aactggttgc acagctgttg gctattaacg accatcggcg 22320 ggaatttcta catcaaaagg gaaggggagt gtacctagat cctcagactg gcgaagaaat 22380 cggcaagggc agtgctgacc ctgcttccct ctcagactca gacagccatg cagaagacag 22440 ggaaggacag ccaactgcgg gtgcaggaag acgagggaga gtggagcgcg gacgggtaca 22500 gcgcagacag cgacagcgtc caggaggaca cttcatccga ggaggacgaa gttccccaga 22560 cggctgcagc gctccagccc gagagcgaaa cagggaaaac gagccccccg ccctcgaatg 22620 cgactgccac caccaccacc atcacaaaga ggaagaaaaa gaaagtaccc attcgatggg 22680 actttcctcc agcacagaac acattgggta agcctgttgc ggttcgcagc agcgatggca 22740 gcgcaactaa actcacagaa gtgaatgata ggaacacatg gaaaccttac aaaggcgcca 22800 tattaaaagc tttatttgcc tacggagggg accgaggggc ggtgcggaga tttttacttt 22860 tcaaccgagg aacattagta cccagaagag taattagcta ttactgtcgt cgctactaca 22920 gccgccgaga ggctttgtga cactgcaccg ccaaccaaaa aacgccgccg acgtctgtct 22980 actccagcag catccgatcc tctacaagcg ctacgcgacg acatctttgt tactatttat 23040 gcaacatttc aacgtgttcg ggcactgggt ctcgacacat actctcttaa agttagaaac 23100 cgtactttac gttccctaac cagaagctgt ctatatcacc aacaagagtc ccagctggaa 23160 cgcaccaaga gggacgccga agctctgcta tctaagcact gccgcacatt atcaagcaat 23220 tgaactttca atgtcagctc cttctcccta tgtgtggact tttcagcctc agcggggtac 23280 cgctgcagga gcttctcaag actacagtac gcgcataaac tggcttagtg ccggccccga 23340 gcttagagga aaagtcgtac aactcaatga ggcaagaaac gctattctga tgaaggaaca 23400 agagtccgtg cccacccctc gagccgaagc caatccttcc ttttggcctg cggcgcttat 23460 tttccaacca cgcccccaag ctattcctgt acatcctgcc catcccgaca cctttgacgc 23520 cgccctaaca agcaacggag cgcaattagc tggaggggcg tggataaact ataaaaacgg 23580 tagtgttcgc tacgaagcgc ccttgcagct ggccgaggaa caggtcggtg gaccgctaaa 23640 cgcctttgct ataaaacatc agctacaact agcaggagga gctctttctg cttctatgtc 23700 cgaaatgagc ggggcgccca gaatcccgcg cagcggaggt attgggtcgt ggcaattttc 23760 tcgagaattc ccccctactg tttaccttaa ccctttttcc ggcagtcctg acacttttcc 23820 tcatcaattt ctttctaact atgactcttt ctctcacacg gtggacgggt atgactgatt 23880 caccgtccag atcggctgcg cttcctgtgc ctgcttctac tcgtattggg ttggtgttta 23940 tgttaagtgg agaggcagag caactgcgcc tgaaacacct ggtccactgt cgccgccaca 24000 agtgctttgc ccgcgactcc ggtgagtttt gctactttga attgcccgag gatcatatcg 24060 agggcccggc gcacggcgtc cggcttaccg cccagggaga gcttgcccgt agcctgattc 24120 gggagtttac ccagcgcccc ctgctagttg agcgggacag gggaccctgt gttctcactg 24180 tgatttgcaa ctgtcctaac cctggattac atcaagatct ttgttgccat ctctgtgctg 24240 agtataataa atacagaaat taaaatatac tggggctcct atcgccatcc tgtaaacgcc 24300 accgtcttca cccgcccaag caaaccaagg cgaaccttac ctggtacttt taacatctct 24360 ccctctgtga tttacaacag tttcaaccca gacggagtga gtctacgaga gaacctctcc 24420 gagctcagct actccatcag aaaaaacacc accctcctta cctgccggga acgtacgagt 24480 gcgtcaccgg ccgctgcacc acacctaccg cctgaccgta aaccagactt tttccggaca 24540 gacctcaata actctgttta ccagaacagg aggtgagctt agaaaaccct tagggtatta 24600 ggccaaaggc gcagctactg tggggtttat gaacaattca agcaactcta cgggctattc 24660 taattcaggt ttctctagaa tcggggttgg ggttattctc tgtcttgtga ttctctttat 24720 tcttatacta acgcttctct gcctaaggct cgccgcctgc tgtgtgcaca tttgcattta 24780 ttgtcagctt tttaaacgct ggggtcgcca cccaagatga ttaggtacat aatcctaggt 24840 ttactcaccc ttgcgtcagc ccacggtacc acccaaaagg tggattttaa ggagccagcc 24900 tgtaatgtta cattcgcagc tgaagctaat gagtgcacca ctcttataaa atgcaccaca 24960 gaacatgaaa agctgcttat tcgccacaaa aacaaaattg gcaagtatgc tgtttatgct 25020 atttggcagc caggtgacac tacagagtat aatgttacag ttttccaggg taaaagtcat 25080 aaaactttta tgtatacttt tccattttat gaaatgtgcg acattaccat gtacatgagc 25140 aaacagtata agttgtggcc cccacaaaat tgtgtggaaa acactggcac tttctgctgc 25200 actgctatgc taattacagt gctcgctttg gtctgtaccc tactctatat taaatacaaa 25260 agcagacgca gctttattga ggaaaagaaa atgccttaat ttactaagtt acaaagctaa 25320 tgtcaccact aactgcttta ctcgctgctt gcaaaacaaa ttcaaaaagt tagcattata 25380 attagaatag gatttaaacc ccccggtcat ttcctgctca ataccattcc cctgaacaat 25440 tgactctatg tgggatatgc tccagcgcta caaccttgaa gtcaggcttc ctggatgtca 25500 gcatctgact ttggccagca cctgtcccgc ggatttgttc cagtccaact acagcgaccc 25560 accctaacag agatgaccaa cacaaccaac gcggccgccg ctaccggact tacatctacc 25620 acaaatacac cccaagtttc tgcctttgtc aataactggg ataacttggg catgtggtgg 25680 ttctccatag cgcttatgtt tgtatgcctt attattatgt ggctcatctg ctgcctaaag 25740 cgcaaacgcg cccgaccacc catctatagt cccatcattg tgctacaccc aaacaatgat 25800 ggaatccata gattggacgg actgaaacac atgttctttt ctcttacagt atgattaaat 25860 gagacatgat tcctcgagtt tttatattac tgacccttgt tgcgcttttt tgtgcgtgct 25920 ccacattggc tgcggtttct cacatcgaag tagactgcat tccagccttc acagtctatt 25980 tgctttacgg atttgtcacc ctcacgctca tctgcagcct catcactgtg gtcatcgcct 26040 ttatccagtg cattgactgg gtctgtgtgc gctttgcata tctcagacac catccccagt 26100 acagggacag gactatagct gagcttctta gaattcttta attatgaaat ttactgtgac 26160 ttttctgctg attatttgca ccctatctgc gttttgttcc ccgacctcca agcctcaaag 26220 acatatatca tgcagattca ctcgtatatg gaatattcca agttgctaca atgaaaaaag 26280 cgatctttcc gaagcctggt tatatgcaat catctctgtt atggtgttct gcagtaccat 26340 cttagcccta gctatatatc cctaccttga cattggctgg aacgcaatag atgccatgaa 26400 ccacccaact ttccccgcgc ccgctatgct tccactgcaa caagttgttg ccggcggctt 26460 tgtcccagcc aatcagcctc gcccaccttc tcccaccccc actgaaatca gctactttaa 26520 tctaacagga ggagatgact gacaccctag atctagaaat ggacggaatt attacagagc 26580 agcgcctgct agaaagacgc agggcagcgg ccgagcaaca gcgcatgaat caagagctcc 26640 aagacatggt taacttgcac cagtgcaaaa ggggtatctt ttgtctggta aagcaggcca 26700 aagtcaccta cgacagtaat accaccggac accgccttag ctacaagttg ccaaccaagc 26760 gtcagaaatt ggtggtcatg gtgggagaaa agcccattac cataactcag cactcggtag 26820 aaaccgaagg ctgcattcac tcaccttgtc aaggacctga ggatctctgc acccttatta 26880 agaccctgtg cggtctcaaa gatcttattc cctttaacta ataaaaaaaa ataataaagc 26940 ttaaaatttg caacacgtac tccggctcgc ctcctatgtt ttctttgcag aaggacaaga 27000 aaaacatggt agaggcgcta aatgctgtct atccctatga cttggcttta ctccccgaag 27060 actatgaaaa gaccaccgcg cccgacgccg tccaagccgc gaatgccgcc cgcccgtttc 27120 taaatcccgt ctacccttac caacaacctg tagccggaga ctttggtttt cccattgtaa 27180 tgcctccctt ttttaatagt tacgatttta ctagcataca tggtaataca ctgtctctgc 27240 ggctcaacaa gcccctaaaa agaacagcaa aaggcttaca acttttacta ggcagtggac 27300 taagtgttaa tgcagacgga cagttagaga gctctgaggg tataagcgag gccgatgctc 27360 ccttacaaat taacgacgga gttcttcagc tatcctttgg ggaaggttta agcgtgaacg 27420 accacggtga actggaaagc aaagggaaag tggaagcagt cactcttcca ctggccttac 27480 aagatcatgt aatgagcctg tcttttggtc aaggtttgca agtaaacgac caaggtcagc 27540 tggaggcgct agcaatggtt cacagcactt ccgcgccctt gaaagttaca aacaacaatc 27600 tagaattagc cctcggacga ggtctcatag tagatgacca aggtcagcta aggttagccc 27660 caaatctact gtggccagaa agtcccctcg ccattgaaca gggaactaac catctaattc 27720 ttttttacaa ccaaagtctg gatgtggaag atggcaaact caccctgccc gaaccttttg 27780 accctctaac tttagacggg ggaagactgc gaatgcagct agctcctaac agcgggcttg 27840 ctgtgactga aaaaggcagc ttaggaatta attggggtga gggaatacaa gtaaaagaac 27900 aaaaaataac actaaaagta acccctgcca acggtcttgc tgtaaccgag caaggtggct 27960 taaacataaa ctggggcaat ggaatcaaag tggatgaaca aaaggtaaca ctaaaaacta 28020 gcaatgaatt tgctttgacc gaaaatgggt tatacctaac tagtcctctg aacccaatcg 28080 aagttaacca acatggacaa ttgggcatag ccctaggcta tggttttcat gctcacaggg 28140 gctacttaga attaactccc caaacactgt ggacaggcct tcccattggg aataatggca 28200 cttttcacac caaacaagac tgcaaaattt ttttaagtct gactcgcttg gggcccatgg 28260 ttcacggaac atttatgctg caagctccac agtatgaact aacaaccaac ggcatgagag 28320 aaattacttt tagttttaac tccactggag gactagaaca acccgctccc gtaacatact 28380 ggggtgccct agatcctccc cccacagcta aagcagctga aatagaaaac cagaagcgcg 28440 tgaaaaaacg cgctgctccc gatccccccg tagaaccacc gcccaaacga cgaggagatc 28500 tagcagttct ctttgcaaaa gttgcagagc aggcaatgga gcttgccaaa gagcaggcag 28560 ttcaggccca acccccagaa catgttaaca ctgattgggc cgaccacatg aacctgctgc 28620 gtttcatgcc caataccttg gtgtacccca ccgcggccac aattgctgct aatcttcaat 28680 tccatgatac ccgcctaagt cttagaaggg caaccctcaa aataagactg aatggcagtc 28740 cagactctgc ctaccaactg gggtttatgc tggaattggt tggaacccaa tctgcatcta 28800 ttgttactga cactataagt ttttggtact atgctgaaga ctattaataa agaatcgttt 28860 gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcgaatca tttttcattc 28920 agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa tcaaactcac 28980 agaaccctag tattcaacct gccacctccc tcccaacaca cagagtacac agtcctttct 29040 ccccggctgg ccttaaaaag catcatatca tgggtaacag acatattctt aggtgttata 29100 ttccacacgg tttcctgtcg agccaaacgc tcatcagtga tattaataaa ctccccgggc 29160 agctcactta agttcatgtc gctgtccagc tgctgagcca caggctgctg tccaacttgc 29220 ggttgcttaa cgggcggcga aggagaagtc cacgcctaca tgggggtaga gtcataatcg 29280 tgcatcagga tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc 29340 tccgtcctgc aggaatacaa catggcagtg gtctcctcag cgatgattcg caccgcccgc 29400 agcataaggc gccttgtcct ccgggcacag cagcgcaccc tgatctcact taaatcagca 29460 cagtaactgc agcacagcac cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat 29520 ccaaagctca tggcggggac cacagaaccc acgtggccat cataccacaa gcgcaggtag 29580 attaagtggc gacccctcat aaacacgctg gacataaaca ttacctcttt tggcatgttg 29640 taattcacca cctcccggta ccatataaac ctctgattaa acatggcgcc atccaccacc 29700 atcctaaacc agctggccaa aacctgcccg ccggctatac actgcaggga accgggactg 29760 gaacaatgac agtggagagc ccaggactcg taaccatgga tcatcatgct cgtcatgata 29820 tcaatgttgg cacaacacag gcacacgtgc atacacttcc tcaggattac aagctcctcc 29880 cgcgttagaa ccatatccca gggaacaacc cattcctgaa tcagcgtaaa tcccacactg 29940 cagggaagac ctcgcacgta actcacgttg tgcattgtca aagtgttaca ttcgggcagc 30000 agcggatgat cctccagtat ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc 30060 ctactgtacg gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt catgccaaat 30120 ggaacgccgg acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga 30180 tctgcgtctc cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt atatccactc 30240 tctcaaagca tccaggcgcc ccctggcttc gggttctatg taaactcctt catgcgccgc 30300 tgccctgata acatccacca ccgcagaata agccacaccc agccaaccta cacattcgtt 30360 ctgcgagtca cacacgggag gagcgggaag agctggaaga accatgtttt tttttttatt 30420 ccaaaagatt atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg 30480 tggcgtggtc aaactctaca gccaaagaac agataatggc atttgtaaga tgttgcacaa 30540 tggcttccaa aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta aacccttcag 30600 ggtgaatctc ctctataaac attccagcac cttcaaccat gcccaaataa ttctcatctc 30660 gccaccttct caatatatct ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa 30720 tctgctccag agcgccctcc accttcagcc tcaagcagcg aatcatgatt gcaaaaattc 30780 aggttcctca cagacctgta taagattcaa aagcggaaca ttaacaaaaa taccgcgatc 30840 ccgtaggtcc cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc 30900 ggccacttcc ccgccaggaa ccatgacaaa agaacccaca ctgattatga cacgcatact 30960 cggagctatg ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg gcgatataaa 31020 atgcaaggtg ctgctcaaaa aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta 31080 gtcatgctca tgcagataaa ggcaggtaag ctccggaacc accacagaaa aagacaccat 31140 ttttctctca aacatgtctg cgggtttctg cataaacaca aaataaaata acaaaaaaac 31200 atttaaacat tagaagcctg tcttacaaca ggaaaaacaa cccttataag cataagacgg 31260 actacggcca tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa aagcaccacc 31320 gacagctcct cggtcatgtc cggagtcata atgtaagact cggtaaacac atcaggttga 31380 ttcacatcgg tcagtgctaa aaagcgaccg aaatagcccg ggggaataca tacccgcagg 31440 cgtagagaca acattacagc ccccatagga ggtataacaa aattaatagg agagaaaaac 31500 acataaacac ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg ctccagaaca 31560 acatacagcg cttccacagc ggcagccata acagtcagcc ttaccagtaa aaaagaaaac 31620 ctattaaaaa aacaccactc gacacggcac cagctcaatc agtcacagtg taaaaaaggg 31680 ccaagtgcag agcgagtata tataggacta aaaaatgacg taacggttaa agtccacaaa 31740 aaacacccag aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa aaacccacaa 31800 cttcctcaaa tcgtcacttc cgttttccca cgttacgtca cttcccattt taagaaaact 31860 acaattccca acacatacaa gttactccgc cctaaaacac acgtcattcc cgggaaaacg 31920 aaacccaact cgggccaaaa acagttggaa caaagccaaa caaaggcgcc attttttgct 31980 aactgtatat tattgatgat g 32001 <210> 82 <211> 35677 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO507) <400> 82 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagca taagtgtctt gctgtcttta 4080 tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct 4140 gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag 4200 cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta 4260 gatgatccag tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa 4320 gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg 4380 gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc 4440 agccatatcc ctccggggat tcatgttgtg cagaaccacc agcacagtgt atccggtgca 4500 cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt 4560 gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc 4620 ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc 4680 gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcggta taatggttcc 4740 atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga 4800 tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg taggggagat 4860 cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta 4920 aatcacacct attaccgggt gcaactggta gttaagagag ctgcagctgc cgtcatccct 4980 gagcaggggg gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc 5040 cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa 5100 cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg 5160 gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc 5220 gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc 5280 atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc 5340 gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc 5400 tgccggtctt cgccctgcgc gtcggccagg tagcatttga ccatggtgtc atagtccagc 5460 ccctccgcgg cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg 5520 cagtgcagac ttttgagggc gtagagcttg ggcgcgagaa ataccgattc cggggagtag 5580 gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc 5640 cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt 5700 tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac 5760 ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac 5820 tctgagacaa aggctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg 5880 tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg 5940 gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg 6000 gggctataaa agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg 6060 agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga 6120 ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg 6180 agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca 6240 aacgacccgt agagggcgtt ggacagcaac ttggcgatgg agcgcagggt ttggtttttg 6300 tcgcgatcgg cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac 6360 cgccattcgg gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg 6420 ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc 6480 cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg 6540 tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct 6600 atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg 6660 tatgggttga gtgggggacc ccatggcatg gggtgggtga gcgcggaggc gtacatgccg 6720 caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt 6780 ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg 6840 ggaccgaggt tgctacgggc gggctgctct gctcggaaga ctatctgcct gaagatggca 6900 tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct 6960 accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg 7020 acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt 7080 cccttttttt tccacagctc gcggttgagg acaaactctt cgcggtcttt ccagtactct 7140 tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg 7200 gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg 7260 agcgaggtgt gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg 7320 aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa 7380 cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata 7440 aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg 7500 gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag ttccaagaag 7560 cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg 7620 gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat 7680 gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg 7740 cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag 7800 cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg 7860 ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta 7920 taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg 7980 aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag 8040 tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag 8100 cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag 8160 agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct 8220 tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc 8280 gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga 8340 tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg 8400 tttacctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg 8460 ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg 8520 gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt 8580 gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg 8640 gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg 8700 cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg 8760 tgagcttgag cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct 8820 ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact 8880 gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt 8940 cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc 9000 ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga 9060 gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg 9120 tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt 9180 tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga 9240 aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg 9300 cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct 9360 cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac 9420 ggcggcgacg acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc 9480 gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc 9540 cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc 9600 taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt 9660 ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 9720 gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg 9780 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca 9840 ccatgtcctt gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt 9900 tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt 9960 cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg 10020 gccgtaggtg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa 10080 gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg 10140 tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag 10200 tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt 10260 acctgagacg cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt 10320 actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg 10380 ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg 10440 acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc 10500 agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg gtcaggcgcg 10560 cgcaatcgtt gacgctctag accgtgcaaa aggagagcct gtaagcgggc actcttccgt 10620 ggtctggtgg ataaattcgc aagggtatca tggcggacga ccggggttcg agccccgtat 10680 ccggccgtcc gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg 10740 tcagacaacg ggggagtgct ccttttggct tccttccagg cgcggcggct gctgcgctag 10800 cttttttggc cactggccgc gcgcagcgta agcggttagg ctggaaagcg aaagcattaa 10860 gtggctcgct ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg ggacccccgg 10920 ttcgagtctc ggaccggccg gactgcggcg aacgggggtt tgcctccccg tcatgcaaga 10980 ccccgcttgc aaattcctcc ggaaacaggg acgagcccct tttttgcttt tcccagatgc 11040 atccggtgct gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc 11100 agacatgcag ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca tccgcggttg 11160 acgcggcagc agatggtgat tacgaacccc cgcggcgccg ggcccggcac tacctggact 11220 tggaggaggg cgagggcctg gcgcggctag gagcgccctc tcctgagcgg tacccaaggg 11280 tgcagctgaa gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc 11340 gcgagggaga ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc 11400 ggcatggcct gaatcgcgag cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa 11460 ccgggattag tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc gcatacgagc 11520 agacggtgaa ccaggagatt aactttcaaa aaagctttaa caaccacgtg cgtacgcttg 11580 tggcgcgcga ggaggtggct ataggactga tgcatctgtg ggactttgta agcgcgctgg 11640 agcaaaaccc aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg cagcacagca 11700 gggacaacga ggcattcagg gatgcgctgc taaacatagt agagcccgag ggccgctggc 11760 tgctcgattt gataaacatc ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg 11820 ctgacaaggt ggccgccatc aactattcca tgcttagcct gggcaagttt tacgcccgca 11880 agatatacca taccccttac gttcccatag acaaggaggt aaagatcgag gggttctaca 11940 tgcgcatggc gctgaaggtg cttaccttga gcgacgacct gggcgtttat cgcaacgagc 12000 gcatccacaa ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc 12060 acagcctgca aagggccctg gctggcacgg gcagcggcga tagagaggcc gagtcctact 12120 ttgacgcggg cgctgacctg cgctgggccc caagccgacg cgccctggag gcagctgggg 12180 ccggacctgg gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat 12240 atgacgagga cgatgagtac gagccagagg acggcgagta ctaagcggtg atgtttctga 12300 tcagatgatg caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc 12360 cggccttaac tccacggacg actggcgcca ggtcatggac cgcatcatgt cgctgactgc 12420 gcgcaatcct gacgcgttcc ggcagcagcc gcaggccaac cggctctccg caattctgga 12480 agcggtggtc ccggcgcgcg caaaccccac gcacgagaag gtgctggcga tcgtaaacgc 12540 gctggccgaa aacagggcca tccggcccga cgaggccggc ctggtctacg acgcgctgct 12600 tcagcgcgtg gctcgttaca acagcggcaa cgtgcagacc aacctggacc ggctggtggg 12660 ggatgtgcgc gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca acctgggctc 12720 catggttgca ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc ggggacagga 12780 ggactacacc aactttgtga gcgcactgcg gctaatggtg actgagacac cgcaaagtga 12840 ggtgtaccag tctgggccag actatttttt ccagaccagt agacaaggcc tgcagaccgt 12900 aaacctgagc caggctttca aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg 12960 cgaccgcgcg accgtgtcta gcttgctgac gcccaactcg cgcctgttgc tgctgctaat 13020 agcgcccttc acggacagtg gcagcgtgtc ccgggacaca tacctaggtc acttgctgac 13080 actgtaccgc gaggccatag gtcaggcgca tgtggacgag catactttcc aggagattac 13140 aagtgtcagc cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa ccctaaacta 13200 cctgctgacc aaccggcggc agaagatccc ctcgttgcac agtttaaaca gcgaggagga 13260 gcgcattttg cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg acggggtaac 13320 gcccagcgtg gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa 13380 ccggccgttt atcaaccgcc taatggacta cttgcatcgc gcggccgccg tgaaccccga 13440 gtatttcacc aatgccatct tgaacccgca ctggctaccg ccccctggtt tctacaccgg 13500 gggattcgag gtgcccgagg gtaacgatgg attcctctgg gacgacatag acgacagcgt 13560 gttttccccg caaccgcaga ccctgctaga gttgcaacag cgcgagcagg cagaggcggc 13620 gctgcgaaag gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc 13680 gcggtcagat gctagtagcc catttccaag cttgataggg tctcttacca gcactcgcac 13740 cacccgcccg cgcctgctgg gcgaggagga gtacctaaac aactcgctgc tgcagccgca 13800 gcgcgaaaaa aacctgcctc cggcatttcc caacaacggg atagagagcc tagtggacaa 13860 gatgagtaga tggaagacgt acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc 13920 cacccgtcgt caaaggcacg accgtcagcg gggtctggtg tgggaggacg atgactcggc 13980 agacgacagc agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc accttcgccc 14040 caggctgggg agaatgtttt aaaaaaaaaa aagcatgatg caaaataaaa aactcaccaa 14100 ggccatggca ccgagcgttg gttttcttgt attcccctta gtatgcggcg cgcggcgatg 14160 tatgaggaag gtcctcctcc ctcctacgag agtgtggtga gcgcggcgcc agtggcggcg 14220 gcgctgggtt ctcccttcga tgctcccctg gacccgccgt ttgtgcctcc gcggtacctg 14280 cggcctaccg gggggagaaa cagcatccgt tactctgagt tggcacccct attcgacacc 14340 acccgtgtgt acctggtgga caacaagtca acggatgtgg catccctgaa ctaccagaac 14400 gaccacagca actttctgac cacggtcatt caaaacaatg actacagccc gggggaggca 14460 agcacacaga ccatcaatct tgacgaccgg tcgcactggg gcggcgacct gaaaaccatc 14520 ctgcatacca acatgccaaa tgtgaacgag ttcatgttta ccaataagtt taaggcgcgg 14580 gtgatggtgt cgcgcttgcc tactaaggac aatcaggtgg agctgaaata cgagtgggtg 14640 gagttcacgc tgcccgaggg caactactcc gagaccatga ccatagacct tatgaacaac 14700 gcgatcgtgg agcactactt gaaagtgggc agacagaacg gggttctgga aagcgacatc 14760 ggggtaaagt ttgacacccg caacttcaga ctggggtttg accccgtcac tggtcttgtc 14820 atgcctgggg tatatacaaa cgaagccttc catccagaca tcattttgct gccaggatgc 14880 ggggtggact tcacccacag ccgcctgagc aacttgttgg gcatccgcaa gcggcaaccc 14940 ttccaggagg gctttaggat cacctacgat gatctggagg gtggtaacat tcccgcactg 15000 ttggatgtgg acgcctacca ggcgagcttg aaagatgaca ccgaacaggg cgggggtggc 15060 gcaggcggca gcaacagcag tggcagcggc gcggaagaga actccaacgc ggcagccgcg 15120 gcaatgcagc cggtggagga catgaacgat catgccattc gcggcgacac ctttgccaca 15180 cgggctgagg agaagcgcgc tgaggccgaa gcagcggccg aagctgccgc ccccgctgcg 15240 caacccgagg tcgagaagcc tcagaagaaa ccggtgatca aacccctgac agaggacagc 15300 aagaaacgca gttacaacct aataagcaat gacagcacct tcacccagta ccgcagctgg 15360 taccttgcat acaactacgg cgaccctcag accggaatcc gctcatggac cctgctttgc 15420 actcctgacg taacctgcgg ctcggagcag gtctactggt cgttgccaga catgatgcaa 15480 gaccccgtga ccttccgctc cacgcgccag atcagcaact ttccggtggt gggcgccgag 15540 ctgttgcccg tgcactccaa gagcttctac aacgaccagg ccgtctactc ccaactcatc 15600 cgccagttta cctctctgac ccacgtgttc aatcgctttc ccgagaacca gattttggcg 15660 cgcccgccag cccccaccat caccaccgtc agtgaaaacg ttcctgctct cacagatcac 15720 gggacgctac cgctgcgcaa cagcatcgga ggagtccagc gagtgaccat tactgacgcc 15780 agacgccgca cctgccccta cgtttacaag gccctgggca tagtctcgcc gcgcgtccta 15840 tcgagccgca ctttttgagc aagcatgtcc atccttatat cgcccagcaa taacacaggc 15900 tggggcctgc gcttcccaag caagatgttt ggcggggcca agaagcgctc cgaccaacac 15960 ccagtgcgcg tgcgcgggca ctaccgcgcg ccctggggcg cgcacaaacg cggccgcact 16020 gggcgcacca ccgtcgatga cgccatcgac gcggtggtgg aggaggcgcg caactacacg 16080 cccacgccgc caccagtgtc cacagtggac gcggccattc agaccgtggt gcgcggagcc 16140 cggcgctatg ctaaaatgaa gagacggcgg aggcgcgtag cacgtcgcca ccgccgccga 16200 cccggcactg ccgcccaacg cgcggcggcg gccctgctta accgcgcacg tcgcaccggc 16260 cgacgggcgg ccatgcgggc cgctcgaagg ctggccgcgg gtattgtcac tgtgcccccc 16320 aggtccaggc gacgagcggc cgccgcagca gccgcggcca ttagtgctat gactcagggt 16380 cgcaggggca acgtgtattg ggtgcgcgac tcggttagcg gcctgcgcgt gcccgtgcgc 16440 acccgccccc cgcgcaacta gattgcaaga aaaaactact tagactcgta ctgttgtatg 16500 tatccagcgg cggcggcgcg caacgaagct atgtccaagc gcaaaatcaa agaagagatg 16560 ctccaggtca tcgcgccgga gatctatggc cccccgaaga aggaagagca ggattacaag 16620 ccccgaaagc taaagcgggt caaaaagaaa aagaaagatg atgatgatga acttgacgac 16680 gaggtggaac tgctgcacgc taccgcgccc aggcgacggg tacagtggaa aggtcgacgc 16740 gtaaaacgtg ttttgcgacc cggcaccacc gtagtcttta cgcccggtga gcgctccacc 16800 cgcacctaca agcgcgtgta tgatgaggtg tacggcgacg aggacctgct tgagcaggcc 16860 aacgagcgcc tcggggagtt tgcctacgga aagcggcata aggacatgct ggcgttgccg 16920 ctggacgagg gcaacccaac acctagccta aagcccgtaa cactgcagca ggtgctgccc 16980 gcgcttgcac cgtccgaaga aaagcgcggc ctaaagcgcg agtctggtga cttggcaccc 17040 accgtgcagc tgatggtacc caagcgccag cgactggaag atgtcttgga aaaaatgacc 17100 gtggaacctg ggctggagcc cgaggtccgc gtgcggccaa tcaagcaggt ggcgccggga 17160 ctgggcgtgc agaccgtgga cgttcagata cccactacca gtagcaccag tattgccacc 17220 gccacagagg gcatggagac acaaacgtcc ccggttgcct cagcggtggc ggatgccgcg 17280 gtgcaggcgg tcgctgcggc cgcgtccaag acctctacgg aggtgcaaac ggacccgtgg 17340 atgtttcgcg tttcagcccc ccggcgcccg cgcggttcga ggaagtacgg cgccgccagc 17400 gcgctactgc ccgaatatgc cctacatcct tccattgcgc ctacccccgg ctatcgtggc 17460 tacacctacc gccccagaag acgagcaact acccgacgcc gaaccaccac tggaacccgc 17520 cgccgccgtc gccgtcgcca gcccgtgctg gccccgattt ccgtgcgcag ggtggctcgc 17580 gaaggaggca ggaccctggt gctgccaaca gcgcgctacc accccagcat cgtttaaaag 17640 ccggtctttg tggttcttgc agatatggcc ctcacctgcc gcctccgttt cccggtgccg 17700 ggattccgag gaagaatgca ccgtaggagg ggcatggccg gccacggcct gacgggcggc 17760 atgcgtcgtg cgcaccaccg gcggcggcgc gcgtcgcacc gtcgcatgcg cggcggtatc 17820 ctgcccctcc ttattccact gatcgccgcg gcgattggcg ccgtgcccgg aattgcatcc 17880 gtggccttgc aggcgcagag acactgatta aaaacaagtt gcatgtggaa aaatcaaaat 17940 aaaaagtctg gactctcacg ctcgcttggt cctgtaacta ttttgtagaa tggaagacat 18000 caactttgcg tctctggccc cgcgacacgg ctcgcgcccg ttcatgggaa actggcaaga 18060 tatcggcacc agcaatatga gcggtggcgc cttcagctgg ggctcgctgt ggagcggcat 18120 taaaaatttc ggttccaccg ttaagaacta tggcagcaag gcctggaaca gcagcacagg 18180 ccagatgctg agggataagt tgaaagagca aaatttccaa caaaaggtgg tagatggcct 18240 ggcctctggc attagcgggg tggtggacct ggccaaccag gcagtgcaaa ataagattaa 18300 cagtaagctt gatccccgcc ctcccgtaga ggagcctcca ccggccgtgg agacagtgtc 18360 tccagagggg cgtggcgaaa agcgtccgcg ccccgacagg gaagaaactc tggtgacgca 18420 aatagacgag cctccctcgt acgaggaggc actaaagcaa ggcctgccca ccacccgtcc 18480 catcgcgccc atggctaccg gagtgctggg ccagcacaca cccgtaacgc tggacctgcc 18540 tccccccgcc gacacccagc agaaacctgt gctgccaggc ccgaccgccg ttgttgtaac 18600 ccgtcctagc cgcgcgtccc tgcgccgcgc cgccagcggt ccgcgatcgt tgcggcccgt 18660 agccagtggc aactggcaaa gcacactgaa cagcatcgtg ggtctggggg tgcaatccct 18720 gaagcgccga cgatgcttct gaatagctaa cgtgtcgtat gtgtgtcatg tatgcgtcca 18780 tgtcgccgcc agaggagctg ctgagccgcc gcgcgcccgc tttccaagat ggctacccct 18840 tcgatgatgc cgcagtggtc ttacatgcac atctcgggcc aggacgcctc ggagtacctg 18900 agccccgggc tggtgcagtt tgcccgcgcc accgagacgt acttcagcct gaataacaag 18960 tttagaaacc ccacggtggc gcctacgcac gacgtgacca cagaccggtc ccagcgtttg 19020 acgctgcggt tcatccctgt ggaccgtgag gatactgcgt actcgtacaa ggcgcggttc 19080 accctagctg tgggtgataa ccgtgtgctg gacatggctt ccacgtactt tgacatccgc 19140 ggcgtgctgg acaggggccc tacttttaag ccctactctg gcactgccta caacgccctg 19200 gctcccaagg gtgccccaaa tccttgcgaa tgggatgaag ctgctactgc tcttgaaata 19260 aacctagaag aagaggacga tgacaacgaa gacgaagtag acgagcaagc tgagcagcaa 19320 aaaactcacg tatttgggca ggcgccttat tctggtataa atattacaaa ggagggtatt 19380 caaataggtg tcgaaggtca aacacctaaa tatgccgata aaacatttca acctgaacct 19440 caaataggag aatctcagtg gtacgaaact gaaattaatc atgcagctgg gagagtcctt 19500 aaaaagacta ccccaatgaa accatgttac ggttcatatg caaaacccac aaatgaaaat 19560 ggagggcaag gcattcttgt aaagcaacaa aatggaaagc tagaaagtca agtggaaatg 19620 caatttttct caactactga ggcgaccgca ggcaatggtg ataacttgac tcctaaagtg 19680 gtattgtaca gtgaagatgt agatatagaa accccagaca ctcatatttc ttacatgccc 19740 actattaagg aaggtaactc acgagaacta atgggccaac aatctatgcc caacaggcct 19800 aattacattg cttttaggga caattttatt ggtctaatgt attacaacag cacgggtaat 19860 atgggtgttc tggcgggcca agcatcgcag ttgaatgctg ttgtagattt gcaagacaga 19920 aacacagagc tttcatacca gcttttgctt gattccattg gtgatagaac caggtacttt 19980 tctatgtgga atcaggctgt tgacagctat gatccagatg ttagaattat tgaaaatcat 20040 ggaactgaag atgaacttcc aaattactgc tttccactgg gaggtgtgat taatacagag 20100 actcttacca aggtaaaacc taaaacaggt caggaaaatg gatgggaaaa agatgctaca 20160 gaattttcag ataaaaatca aataagagtt ggaaataatt ttgccatgga aatcaatcta 20220 aatgccaacc tgtggagaaa tttcctgtac tccaacatag cgctgtattt gcccgacaag 20280 ctaaagtaca gtccttccaa cgtaaaaatt tctgataacc caaacaccta cgactacatg 20340 aacaagcgag tggtggctcc cgggttagtg gactgctaca ttaaccttgg agcacgctgg 20400 tcccttgact atatggacaa cgtcaaccca tttaaccacc accgcaatgc tggcctgcgc 20460 taccgctcaa tgttgctggg caatggtcgc tatgtgccct tccacatcca ggtgcctcag 20520 aagttctttg ccattaaaaa cctccttctc ctgccgggct catacaccta cgagtggaac 20580 ttcaggaagg atgttaacat ggttctgcag agctccctag gaaatgacct aagggttgac 20640 ggagccagca ttaagtttga tagcatttgc ctttacgcca ccttcttccc catggcccac 20700 aacaccgcct ccacgcttga ggccatgctt agaaacgaca ccaacgacca gtcctttaac 20760 gactatctct ccgccgccaa catgctctac cctatacccg ccaacgctac caacgtgccc 20820 atatccatcc cctcccgcaa ctgggcggct ttccgcggct gggccttcac gcgccttaag 20880 actaaggaaa ccccatcact gggctcgggc tacgaccctt attacaccta ctctggctct 20940 ataccctacc tagatggaac cttttacctc aaccacacct ttaagaaggt ggccattacc 21000 tttgactctt ctgtcagctg gcctggcaat gaccgcctgc ttacccccaa cgagtttgaa 21060 attaagcgct cagttgacgg ggagggttac aacgttgccc agtgtaacat gaccaaagac 21120 tggttcctgg tacaaatgct agctaactac aacattggct accagggctt ctatatccca 21180 gagagctaca aggaccgcat gtactccttc tttagaaact tccagcccat gagccgtcag 21240 gtggtggatg atactaaata caaggactac caacaggtgg gcatcctaca ccaacacaac 21300 aactctggat ttgttggcta ccttgccccc accatgcgcg aaggacaggc ctaccctgct 21360 aacttcccct atccgcttat aggcaagacc gcagttgaca gcattaccca gaaaaagttt 21420 ctttgcgatc gcaccctttg gcgcatccca ttctccagta actttatgtc catgggcgca 21480 ctcacagacc tgggccaaaa ccttctctac gccaactccg cccacgcgct agacatgact 21540 tttgaggtgg atcccatgga cgagcccacc cttctttatg ttttgtttga agtctttgac 21600 gtggtccgtg tgcaccggcc gcaccgcggc gtcatcgaaa ccgtgtacct gcgcacgccc 21660 ttctcggccg gcaacgccac aacataaaga agcaagcaac atcaacaaca gctgccgcca 21720 tgggctccag tgagcaggaa ctgaaagcca ttgtcaaaga tcttggttgt gggccatatt 21780 ttttgggcac ctatgacaag cgctttccag gctttgtttc tccacacaag ctcgcctgcg 21840 ccatagtcaa tacggccggt cgcgagactg ggggcgtaca ctggatggcc tttgcctgga 21900 acccgcactc aaaaacatgc tacctctttg agccctttgg cttttctgac cagcgactca 21960 agcaggttta ccagtttgag tacgagtcac tcctgcgccg tagcgccatt gcttcttccc 22020 ccgaccgctg tataacgctg gaaaagtcca cccaaagcgt acaggggccc aactcggccg 22080 cctgtggact attctgctgc atgtttctcc acgcctttgc caactggccc caaactccca 22140 tggatcacaa ccccaccatg aaccttatta ccggggtacc caactccatg ctcaacagtc 22200 cccaggtaca gcccaccctg cgtcgcaacc aggaacagct ctacagcttc ctggagcgcc 22260 actcgcccta cttccgcagc cacagtgcgc agattaggag cgccacttct ttttgtcact 22320 tgaaaaacat gtaaaaataa tgtactagag acactttcaa taaaggcaaa tgcttttatt 22380 tgtacactct cgggtgatta tttaccccca cccttgccgt ctgcgccgtt taaaaatcaa 22440 aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga tactggtgtt 22500 tagtgctcca cttaaactca ggcacaacca tccgcggcag ctcggtgaag ttttcactcc 22560 acaggctgcg caccatcacc aacgcgttta gcaggtcggg cgccgatatc ttgaagtcgc 22620 agttggggcc tccgccctgc gcgcgcgagt tgcgatacac agggttgcag cactggaaca 22680 ctatcagcgc cgggtggtgc acgctggcca gcacgctctt gtcggagatc agatccgcgt 22740 ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt tggtagctgc cttcccaaaa 22800 agggcgcgtg cccaggcttt gagttgcact cgcaccgtag tggcatcaaa aggtgaccgt 22860 gcccggtctg ggcgttagga tacagcgcct gcataaaagc cttgatctgc ttaaaagcca 22920 cctgagcctt tgcgccttca gagaagaaca tgccgcaaga cttgccggaa aactgattgg 22980 ccggacaggc cgcgtcgtgc acgcagcacc ttgcgtcggt gttggagatc tgcaccacat 23040 ttcggcccca ccggttcttc acgatcttgg ccttgctaga ctgctccttc agcgcgcgct 23100 gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc cttatttatc ataatgcttc 23160 cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg gtgcagccac aacgcgcagc 23220 ccgtgggctc gtgatgcttg taggtcacct ctgcaaacga ctgcaggtac gcctgcagga 23280 atcgccccat catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc aacccgcggt 23340 gctcctcgtt cagccaggtc ttgcatacgg ccgccagagc ttccacttgg tcaggcagta 23400 gtttgaagtt cgcctttaga tcgttatcca cgtggtactt gtccatcagc gcgcgcgcag 23460 cctccatgcc cttctcccac gcagacacga tcggcacact cagcgggttc atcaccgtaa 23520 tttcactttc cgcttcgctg ggctcttcct cttcctcttg cgtccgcata ccacgcgcca 23580 ctgggtcgtc ttcattcagc cgccgcactg tgcgcttacc tcctttgcca tgcttgatta 23640 gcaccggtgg gttgctgaaa cccaccattt gtagcgccac atcttctctt tcttcctcgc 23700 tgtccacgat tacctctggt gatggcgggc gctcgggctt gggagaaggg cgcttctttt 23760 tcttcttggg cgcaatggcc aaatccgccg ccgaggtcga tggccgcggg ctgggtgtgc 23820 gcggcaccag cgcgtcttgt gatgagtctt cctcgtcctc ggactcgata cgccgcctca 23880 tccgcttttt tgggggcgcc cggggaggcg gcggcgacgg ggacggggac gacacgtcct 23940 ccatggttgg gggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt tcgcgctgct 24000 cctcttcccg actggccatt tccttctcct ataggcagaa aaagatcatg gagtcagtcg 24060 agaagaagga cagcctaacc gccccctctg agttcgccac caccgcctcc accgatgccg 24120 ccaacgcgcc taccaccttc cccgtcgagg cacccccgct tgaggaggag gaagtgatta 24180 tcgagcagga cccaggtttt gtaagcgaag acgacgagga ccgctcagta ccaacagagg 24240 ataaaaagca agaccaggac aacgcagagg caaacgagga acaagtcggg cggggggacg 24300 aaaggcatgg cgactaccta gatgtgggag acgacgtgct gttgaagcat ctgcagcgcc 24360 agtgcgccat tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc gccatagcgg 24420 atgtcagcct tgcctacgaa cgccacctat tctcaccgcg cgtacccccc aaacgccaag 24480 aaaacggcac atgcgagccc aacccgcgcc tcaacttcta ccccgtattt gccgtgccag 24540 aggtgcttgc cacctatcac atctttttcc aaaactgcaa gataccccta tcctgccgtg 24600 ccaaccgcag ccgagcggac aagcagctgg ccttgcggca gggcgctgtc atacctgata 24660 tcgcctcgct caacgaagtg ccaaaaatct ttgagggtct tggacgcgac gagaagcgcg 24720 cggcaaacgc tctgcaacag gaaaacagcg aaaatgaaag tcactctgga gtgttggtgg 24780 aactcgaggg tgacaacgcg cgcctagccg tactaaaacg cagcatcgag gtcacccact 24840 ttgcctaccc ggcacttaac ctacccccca aggtcatgag cacagtcatg agtgagctga 24900 tcgtgcgccg tgcgcagccc ctggagaggg atgcaaattt gcaagaacaa acagaggagg 24960 gcctacccgc agttggcgac gagcagctag cgcgctggct tcaaacgcgc gagcctgccg 25020 acttggagga gcgacgcaaa ctaatgatgg ccgcagtgct cgttaccgtg gagcttgagt 25080 gcatgcagcg gttctttgct gacccggaga tgcagcgcaa gctagaggaa acattgcact 25140 acacctttcg acagggctac gtacgccagg cctgcaagat ctccaacgtg gagctctgca 25200 acctggtctc ctaccttgga attttgcacg aaaaccgcct tgggcaaaac gtgcttcatt 25260 ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac ttatttctat 25320 gctacacctg gcagacggcc atgggcgttt ggcagcagtg cttggaggag tgcaacctca 25380 aggagctgca gaaactgcta aagcaaaact tgaaggacct atggacggcc ttcaacgagc 25440 gctccgtggc cgcgcacctg gcggacatca ttttccccga acgcctgctt aaaaccctgc 25500 aacagggtct gccagacttc accagtcaaa gcatgttgca gaactttagg aactttatcc 25560 tagagcgctc aggaatcttg cccgccacct gctgtgcact tcctagcgac tttgtgccca 25620 ttaagtaccg cgaatgccct ccgccgcttt ggggccactg ctaccttctg cagctagcca 25680 actaccttgc ctaccactct gacataatgg aagacgtgag cggtgacggt ctactggagt 25740 gtcactgtcg ctgcaaccta tgcaccccgc accgctccct ggtttgcaat tcgcagctgc 25800 ttaacgaaag tcaaattatc ggtacctttg agctgcaggg tccctcgcct gacgaaaagt 25860 ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac gtcggcttac cttcgcaaat 25920 ttgtacctga ggactaccac gcccacgaga ttaggttcta cgaagaccaa tcccgcccgc 25980 caaatgcgga gcttaccgcc tgcgtcatta cccagggcca cattcttggc caattgcaag 26040 ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg acggggggtt tacttggacc 26100 cccagtccgg cgaggagctc aacccaatcc ccccgccgcc gcagccctat cagcagcagc 26160 cgcgggccct tgcttcccag gatggcaccc aaaaagaagc tgcagctgcc gccgccaccc 26220 acggacgagg aggaatactg ggacagtcag gcagaggagg ttttggacga ggaggaggag 26280 gacatgatgg aagactggga gagcctagac gaggaagctt ccgaggtcga agaggtgtca 26340 gacgaaacac cgtcaccctc ggtcgcattc ccctcgccgg cgccccagaa atcggcaacc 26400 ggttccagca tggctacaac ctccgctcct caggcgccgc cggcactgcc cgttcgccga 26460 cccaaccgta gatgggacac cactggaacc agggccggta agtccaagca gccgccgccg 26520 ttagcccaag agcaacaaca gcgccaaggc taccgctcat ggcgcgggca caagaacgcc 26580 atagttgctt gcttgcaaga ctgtgggggc aacatctcct tcgcccgccg ctttcttctc 26640 taccatcacg gcgtggcctt cccccgtaac atcctgcatt actaccgtca tctctacagc 26700 ccatactgca ccggcggcag cggcagcggc agcaacagca gcggccacac agaagcaaag 26760 gcgaccggat agcaagactc tgacaaagcc caagaaatcc acagcggcgg cagcagcagg 26820 aggaggagcg ctgcgtctgg cgcccaacga acccgtatcg acccgcgagc ttagaaacag 26880 gatttttccc actctgtatg ctatatttca acagagcagg ggccaagaac aagagctgaa 26940 aataaaaaac aggtctctgc gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga 27000 tcagcttcgg cgcacgctgg aagacgcgga ggctctcttc agtaaatact gcgcgctgac 27060 tcttaaggac tagtttcgcg ccctttctca aatttaagcg cgaaaactac gtcatctcca 27120 gcggccacac ccggcgccag cacctgtcgt cagcgccatt tatgagcaag gaaattccca 27180 cgccctacat gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact 27240 actcaacccg aataaactac atgagcgcgg gaccccacat gatatcccgg gtcaacggaa 27300 tacgcgccca ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta 27360 ataaccttaa tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca 27420 ccactgtggt acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc 27480 agcttgcggg cggctttcgt cacagggtgc ggtcgcccgg gcagggtata actcacctga 27540 caatcagagg gcgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc 27600 gtccggacgg gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg 27660 caatcctaac tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactctgc 27720 aatttattga ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc 27780 actatccgga tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg 27840 actgaatgtt aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc 27900 gccacaagtg ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc 27960 atatcgaggg cccggcgcac ggcgtccggc ttaccgccca gggagagctt gcccgtagcc 28020 tgattcggga gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc 28080 tcactgtgat ttgcaactgt cctaaccctg gattacatca agatctttgt tgccatctct 28140 gtgctgagta taataaatac agaaattaaa atatactggg gctcctatcg ccatcctgta 28200 aacgccaccg tcttcacccg cccaagcaaa ccaaggcgaa ccttacctgg tacttttaac 28260 atctctccct ctgtgattta caacagtttc aacccagacg gagtgagtct acgagagaac 28320 ctctccgagc tcagctactc catcagaaaa aacaccaccc tccttacctg ccgggaacgt 28380 acgagtgcgt caccggccgc tgcaccacac ctaccgcctg accgtaaacc agactttttc 28440 cggacagacc tcaataactc tgtttaccag aacaggaggt gagcttagaa aacccttagg 28500 gtattaggcc aaaggcgcag ctactgtggg gtttatgaac aattcaagca actctacggg 28560 ctattctaat tcaggtttct ctagaatcgg ggttggggtt attctctgtc ttgtgattct 28620 ctttattctt atactaacgc ttctctgcct aaggctcgcc gcctgctgtg tgcacatttg 28680 catttattgt cagcttttta aacgctgggg tcgccaccca agatgattag gtacataatc 28740 ctaggtttac tcacccttgc gtcagcccac ggtaccaccc aaaaggtgga ttttaaggag 28800 ccagcctgta atgttacatt cgcagctgaa gctaatgagt gcaccactct tataaaatgc 28860 accacagaac atgaaaagct gcttattcgc cacaaaaaca aaattggcaa gtatgctgtt 28920 tatgctattt ggcagccagg tgacactaca gagtataatg ttacagtttt ccagggtaaa 28980 agtcataaaa cttttatgta tacttttcca ttttatgaaa tgtgcgacat taccatgtac 29040 atgagcaaac agtataagtt gtggccccca caaaattgtg tggaaaacac tggcactttc 29100 tgctgcactg ctatgctaat tacagtgctc gctttggtct gtaccctact ctatattaaa 29160 tacaaaagca gacgcagctt tattgaggaa aagaaaatgc cttaatttac taagttacaa 29220 agctaatgtc accactaact gctttactcg ctgcttgcaa aacaaattca aaaagttagc 29280 attataatta gaataggatt taaacccccc ggtcatttcc tgctcaatac cattcccctg 29340 aacaattgac tctatgtggg atatgctcca gcgctacaac cttgaagtca ggcttcctgg 29400 atgtcagcat ctgactttgg ccagcacctg tcccgcggat ttgttccagt ccaactacag 29460 cgacccaccc taacagagat gaccaacaca accaacgcgg ccgccgctac cggacttaca 29520 tctaccacaa atacacccca agtttctgcc tttgtcaata actgggataa cttgggcatg 29580 tggtggttct ccatagcgct tatgtttgta tgccttatta ttatgtggct catctgctgc 29640 ctaaagcgca aacgcgcccg accacccatc tatagtccca tcattgtgct acacccaaac 29700 aatgatggaa tccatagatt ggacggactg aaacacatgt tcttttctct tacagtatga 29760 ttaaatgaga catgattcct cgagttttta tattactgac ccttgttgcg cttttttgtg 29820 cgtgctccac attggctgcg gtttctcaca tcgaagtaga ctgcattcca gccttcacag 29880 tctatttgct ttacggattt gtcaccctca cgctcatctg cagcctcatc actgtggtca 29940 tcgcctttat ccagtgcatt gactgggtct gtgtgcgctt tgcatatctc agacaccatc 30000 cccagtacag ggacaggact atagctgagc ttcttagaat tctttaatta tgaaatttac 30060 tgtgactttt ctgctgatta tttgcaccct atctgcgttt tgttccccga cctccaagcc 30120 tcaaagacat atatcatgca gattcactcg tatatggaat attccaagtt gctacaatga 30180 aaaaagcgat ctttccgaag cctggttata tgcaatcatc tctgttatgg tgttctgcag 30240 taccatctta gccctagcta tatatcccta ccttgacatt ggctggaacg caatagatgc 30300 catgaaccac ccaactttcc ccgcgcccgc tatgcttcca ctgcaacaag ttgttgccgg 30360 cggctttgtc ccagccaatc agcctcgccc accttctccc acccccactg aaatcagcta 30420 ctttaatcta acaggaggag atgactgaca ccctagatct agaaatggac ggaattatta 30480 cagagcagcg cctgctagaa agacgcaggg cagcggccga gcaacagcgc atgaatcaag 30540 agctccaaga catggttaac ttgcaccagt gcaaaagggg tatcttttgt ctggtaaagc 30600 aggccaaagt cacctacgac agtaatacca ccggacaccg ccttagctac aagttgccaa 30660 ccaagcgtca gaaattggtg gtcatggtgg gagaaaagcc cattaccata actcagcact 30720 cggtagaaac cgaaggctgc attcactcac cttgtcaagg acctgaggat ctctgcaccc 30780 ttattaagac cctgtgcggt ctcaaagatc ttattccctt taactaataa aaaaaaataa 30840 taaagcatca cttacttaaa atcagttagc aaatttctgt ccagtttatt cagcagcacc 30900 tccttgccct cctcccagct ctggtattgc agcttcctcc tggctgcaaa ctttctccac 30960 aatctaaatg gaatgtcagt ttcctcctgt tcctgtccat ccgcacccac tatcttcatg 31020 ttgttgcaga tgaagcgcgc aagaccgtct gaagatacct tcaaccccgt gtatccatat 31080 gacacggaaa ccggtcctcc aactgtgcct tttcttactc ctccctttgt atcccccaat 31140 gggtttcaag agagtccccc tggggtactc tctttgcgcc tatccgaacc tctagttacc 31200 tccaatggca tgcttgcgct caaaatgggc aacggcctct ctctggacga ggccggcaac 31260 cttacctccc aaaatgtaac cactgtgagc ccacctctca aaaaaaccaa gtcaaacata 31320 aacctggaaa tatctgcacc cctcacagtt acctcagaag ccctaactgt ggctgccgcc 31380 gcacctctaa tggtcgcggg caacacactc accatgcaat cacaggcccc gctaaccgtg 31440 cacgactcca aacttagcat tgccacccaa ggacccctca cagtgtcaga aggaaagcta 31500 gccctgcaaa catcaggccc cctcaccacc accgatagca gtacccttac tatcactgcc 31560 tcaccccctc taactactgc cactggtagc ttgggcattg acttgaaaga gcccatttat 31620 acacaaaatg gaaaactagg actaaagtac ggggctcctt tgcatgtaac agacgaccta 31680 aacactttga ccgtagcaac tggtccaggt gtgactatta ataatacttc cttgcaaact 31740 aaagttactg gagccttggg ttttgattca caaggcaata tgcaacttaa tgtagcagga 31800 ggactaagga ttgattctca aaacagacgc cttatacttg atgttagtta tccgtttgat 31860 gctcaaaacc aactaaatct aagactagga cagggccctc tttttataaa ctcagcccac 31920 aacttggata ttaactacaa caaaggcctt tacttgttta cagcttcaaa caattccaaa 31980 aagcttgagg ttaacctaag cactgccaag gggttgatgt ttgacgctac agccatagcc 32040 attaatgcag gagatgggct tgaatttggt tcacctaatg caccaaacac aaatcccctc 32100 aaaacaaaaa ttggccatgg cctagaattt gattcaaaca aggctatggt tcctaaacta 32160 ggaactggcc ttagttttga cagcacaggt gccattacag taggaaacaa aaataatgat 32220 aagctaactt tatggactgg aataaaccct ccacctaact gtcaaattgt ggaaaacact 32280 aatacaaatg atggcaaact tactttagta ttagtaaaaa acggagggct tgttaatggc 32340 tacgtgtctc tagttggtgt atcagacact gtgaaccaaa tgttcacaca aaagacagca 32400 aacatccaat taagattata ttttgactct tctggaaatc tattaactga tgaatcagac 32460 ttaaaaattc cacttaaaaa taaatcttct acagcgacca gtgaaactgt agccagcagc 32520 aaagccttta tgccaagtac tacagcttat cccttcaaca ccactactag ggatagtgaa 32580 aactacattc atggaatatg ttactacatg actagttatg atagaagtct atttcccttg 32640 aacatttcta taatgctaaa cagccgtatg atttcttcca atgttgccta tgccatacaa 32700 tttgaatgga atctaaatgc aagtgaatct ccagaaagca acatagctac gctgaccaca 32760 tccccctttt tcttttctta cattacagaa gacgacaact aataaagaat cgtttgtgtt 32820 atgtttcaac gtgtttattt ttcaattgca gaaaatttca agtcattttt cattcagtag 32880 tatagcccca ccaccacata gcttatacag atcaccgtac cttaatcaaa cctacatggg 32940 ggtagagtca taatcgtgca tcaggatagg gcggtggtgc tgcagcagcg cgcgaataaa 33000 ctgctgccgc cgccgctccg tcctgcagga atacaacatg gcagtggtct cctcagcgat 33060 gattcgcacc gcccgcagca taaggcgcct tgtcctccgg gcacagcagc gcaccctgat 33120 ctcacttaaa tcagcacagt aactgcagca cagcaccaca atattgttca aaatcccaca 33180 gtgcaaggcg ctgtatccaa agctcatggc ggggaccaca gaacccacgt ggccatcata 33240 ccacaagcgc aggtagatta agtggcgacc cctcataaac acgctggaca taaacattac 33300 ctcttttggc atgttgtaat tcaccacctc ccggtaccat ataaacctct gattaaacat 33360 ggcgccatcc accaccatcc taaaccagct ggccaaaacc tgcccgccgg ctatacactg 33420 cagggaaccg ggactggaac aatgacagtg gagagcccag gactcgtaac catggatcat 33480 catgctcgtc atgatatcaa tgttggcaca acacaggcac acgtgcatac acttcctcag 33540 gattacaagc tcctcccgcg ttagaaccat atcccaggga acaacccatt cctgaatcag 33600 cgtaaatccc acactgcagg gaagacctcg cacgtaactc acgttgtgca ttgtcaaagt 33660 gttacattcg ggcagcagcg gatgatcctc cagtatggta gcgcgggttt ctgtctcaaa 33720 aggaggtaga cgatccctac tgtacggagt gcgccgagac aaccgagatc gtgttggtcg 33780 tagtgtcatg ccaaatggaa cgccggacgt agtcatattt cctgaagcaa aaccaggtgc 33840 gggcgtgaca aacagatctg cgtctccggt ctcgccgctt agatcgctct gtgtagtagt 33900 tgtagtatat ccactctctc aaagcatcca ggcgccccct ggcttcgggt tctatgtaaa 33960 ctccttcatg cgccgctgcc ctgataacat ccaccaccgc agaataagcc acacccagcc 34020 aacctacaca ttcgttctgc gagtcacaca cgggaggagc gggaagagct ggaagaacca 34080 tgtttttttt tttattccaa aagattatcc aaaacctcaa aatgaagatc tattaagtga 34140 acgcgctccc ctccggtggc gtggtcaaac tctacagcca aagaacagat aatggcattt 34200 gtaagatgtt gcacaatggc ttccaaaagg caaacggccc tcacgtccaa gtggacgtaa 34260 aggctaaacc cttcagggtg aatctcctct ataaacattc cagcaccttc aaccatgccc 34320 aaataattct catctcgcca ccttctcaat atatctctaa gcaaatcccg aatattaagt 34380 ccggccattg taaaaatctg ctccagagcg ccctccacct tcagcctcaa gcagcgaatc 34440 atgattgcaa aaattcaggt tcctcacaga cctgtataag attcaaaagc ggaacattaa 34500 caaaaatacc gcgatcccgt aggtcccttc gcagggccag ctgaacataa tcgtgcaggt 34560 ctgcacggac cagcgcggcc acttccccgc caggaaccat gacaaaagaa cccacactga 34620 ttatgacacg catactcgga gctatgctaa ccagcgtagc cccgatgtaa gcttgttgca 34680 tgggcggcga tataaaatgc aaggtgctgc tcaaaaaatc aggcaaagcc tcgcgcaaaa 34740 aagaaagcac atcgtagtca tgctcatgca gataaaggca ggtaagctcc ggaaccacca 34800 cagaaaaaga caccattttt ctctcaaaca tgtctgcggg tttctgcata aacacaaaat 34860 aaaataacaa aaaaacattt aaacattaga agcctgtctt acaacaggaa aaacaaccct 34920 tataagcata agacggacta cggccatgcc ggcgtgaccg taaaaaaact ggtcaccgtg 34980 attaaaaagc accaccgaca gctcctcggt catgtccgga gtcataatgt aagactcggt 35040 aaacacatca ggttgattca catcggtcag tgctaaaaag cgaccgaaat agcccggggg 35100 aatacatacc cgcaggcgta gagacaacat tacagccccc ataggaggta taacaaaatt 35160 aataggagag aaaaacacat aaacacctga aaaaccctcc tgcctaggca aaatagcacc 35220 ctcccgctcc agaacaacat acagcgcttc cacagcggca gccataacag tcagccttac 35280 cagtaaaaaa gaaaacctat taaaaaaaca ccactcgaca cggcaccagc tcaatcagtc 35340 acagtgtaaa aaagggccaa gtgcagagcg agtatatata ggactaaaaa atgacgtaac 35400 ggttaaagtc cacaaaaaac acccagaaaa ccgcacgcga acctacgccc agaaacgaaa 35460 gccaaaaaac ccacaacttc ctcaaatcgt cacttccgtt ttcccacgtt acgtcacttc 35520 ccattttaag aaaactacaa ttcccaacac atacaagtta ctccgcccta aaacctacgt 35580 cacccgcccc gttcccacgc cccgcgccac gtcacaaact ccaccccctc attatcatat 35640 tggcttcaat ccaaaataag gtatattatt gatgatg 35677 <210> 83 <211> 35683 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO508) <400> 83 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagca taagtgtctt gctgtcttta 4080 tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct 4140 gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag 4200 cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta 4260 gatgatccag tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa 4320 gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg 4380 gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc 4440 agccatatcc ctccggggat tcatgttgtg cagaaccacc agcacagtgt atccggtgca 4500 cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt 4560 gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc 4620 ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc 4680 gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcggta taatggttcc 4740 atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga 4800 tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg taggggagat 4860 cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta 4920 aatcacacct attaccgggt gcaactggta gttaagagag ctgcagctgc cgtcatccct 4980 gagcaggggg gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc 5040 cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa 5100 cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg 5160 gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc 5220 gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc 5280 atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc 5340 gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc 5400 tgccggtctt cgccctgcgc gtcggccagg tagcatttga ccatggtgtc atagtccagc 5460 ccctccgcgg cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg 5520 cagtgcagac ttttgagggc gtagagcttg ggcgcgagaa ataccgattc cggggagtag 5580 gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc 5640 cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt 5700 tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac 5760 ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac 5820 tctgagacaa aggctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg 5880 tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg 5940 gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg 6000 gggctataaa agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg 6060 agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga 6120 ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg 6180 agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca 6240 aacgacccgt agagggcgtt ggacagcaac ttggcgatgg agcgcagggt ttggtttttg 6300 tcgcgatcgg cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac 6360 cgccattcgg gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg 6420 ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc 6480 cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg 6540 tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct 6600 atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg 6660 tatgggttga gtgggggacc ccatggcatg gggtgggtga gcgcggaggc gtacatgccg 6720 caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt 6780 ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg 6840 ggaccgaggt tgctacgggc gggctgctct gctcggaaga ctatctgcct gaagatggca 6900 tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct 6960 accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg 7020 acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt 7080 cccttttttt tccacagctc gcggttgagg acaaactctt cgcggtcttt ccagtactct 7140 tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg 7200 gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg 7260 agcgaggtgt gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg 7320 aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa 7380 cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata 7440 aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg 7500 gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag ttccaagaag 7560 cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg 7620 gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat 7680 gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg 7740 cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag 7800 cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg 7860 ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta 7920 taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg 7980 aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag 8040 tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag 8100 cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag 8160 agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct 8220 tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc 8280 gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga 8340 tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg 8400 tttacctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg 8460 ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg 8520 gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt 8580 gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg 8640 gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg 8700 cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg 8760 tgagcttgag cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct 8820 ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact 8880 gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt 8940 cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc 9000 ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga 9060 gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg 9120 tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt 9180 tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga 9240 aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg 9300 cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct 9360 cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac 9420 ggcggcgacg acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc 9480 gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc 9540 cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc 9600 taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt 9660 ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 9720 gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg 9780 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca 9840 ccatgtcctt gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt 9900 tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt 9960 cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg 10020 gccgtaggtg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa 10080 gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg 10140 tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag 10200 tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt 10260 acctgagacg cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt 10320 actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg 10380 ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg 10440 acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc 10500 agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg gtcaggcgcg 10560 cgcaatcgtt gacgctctag accgtgcaaa aggagagcct gtaagcgggc actcttccgt 10620 ggtctggtgg ataaattcgc aagggtatca tggcggacga ccggggttcg agccccgtat 10680 ccggccgtcc gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg 10740 tcagacaacg ggggagtgct ccttttggct tccttccagg cgcggcggct gctgcgctag 10800 cttttttggc cactggccgc gcgcagcgta agcggttagg ctggaaagcg aaagcattaa 10860 gtggctcgct ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg ggacccccgg 10920 ttcgagtctc ggaccggccg gactgcggcg aacgggggtt tgcctccccg tcatgcaaga 10980 ccccgcttgc aaattcctcc ggaaacaggg acgagcccct tttttgcttt tcccagatgc 11040 atccggtgct gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc 11100 agacatgcag ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca tccgcggttg 11160 acgcggcagc agatggtgat tacgaacccc cgcggcgccg ggcccggcac tacctggact 11220 tggaggaggg cgagggcctg gcgcggctag gagcgccctc tcctgagcgg tacccaaggg 11280 tgcagctgaa gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc 11340 gcgagggaga ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc 11400 ggcatggcct gaatcgcgag cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa 11460 ccgggattag tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc gcatacgagc 11520 agacggtgaa ccaggagatt aactttcaaa aaagctttaa caaccacgtg cgtacgcttg 11580 tggcgcgcga ggaggtggct ataggactga tgcatctgtg ggactttgta agcgcgctgg 11640 agcaaaaccc aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg cagcacagca 11700 gggacaacga ggcattcagg gatgcgctgc taaacatagt agagcccgag ggccgctggc 11760 tgctcgattt gataaacatc ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg 11820 ctgacaaggt ggccgccatc aactattcca tgcttagcct gggcaagttt tacgcccgca 11880 agatatacca taccccttac gttcccatag acaaggaggt aaagatcgag gggttctaca 11940 tgcgcatggc gctgaaggtg cttaccttga gcgacgacct gggcgtttat cgcaacgagc 12000 gcatccacaa ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc 12060 acagcctgca aagggccctg gctggcacgg gcagcggcga tagagaggcc gagtcctact 12120 ttgacgcggg cgctgacctg cgctgggccc caagccgacg cgccctggag gcagctgggg 12180 ccggacctgg gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat 12240 atgacgagga cgatgagtac gagccagagg acggcgagta ctaagcggtg atgtttctga 12300 tcagatgatg caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc 12360 cggccttaac tccacggacg actggcgcca ggtcatggac cgcatcatgt cgctgactgc 12420 gcgcaatcct gacgcgttcc ggcagcagcc gcaggccaac cggctctccg caattctgga 12480 agcggtggtc ccggcgcgcg caaaccccac gcacgagaag gtgctggcga tcgtaaacgc 12540 gctggccgaa aacagggcca tccggcccga cgaggccggc ctggtctacg acgcgctgct 12600 tcagcgcgtg gctcgttaca acagcggcaa cgtgcagacc aacctggacc ggctggtggg 12660 ggatgtgcgc gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca acctgggctc 12720 catggttgca ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc ggggacagga 12780 ggactacacc aactttgtga gcgcactgcg gctaatggtg actgagacac cgcaaagtga 12840 ggtgtaccag tctgggccag actatttttt ccagaccagt agacaaggcc tgcagaccgt 12900 aaacctgagc caggctttca aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg 12960 cgaccgcgcg accgtgtcta gcttgctgac gcccaactcg cgcctgttgc tgctgctaat 13020 agcgcccttc acggacagtg gcagcgtgtc ccgggacaca tacctaggtc acttgctgac 13080 actgtaccgc gaggccatag gtcaggcgca tgtggacgag catactttcc aggagattac 13140 aagtgtcagc cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa ccctaaacta 13200 cctgctgacc aaccggcggc agaagatccc ctcgttgcac agtttaaaca gcgaggagga 13260 gcgcattttg cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg acggggtaac 13320 gcccagcgtg gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa 13380 ccggccgttt atcaaccgcc taatggacta cttgcatcgc gcggccgccg tgaaccccga 13440 gtatttcacc aatgccatct tgaacccgca ctggctaccg ccccctggtt tctacaccgg 13500 gggattcgag gtgcccgagg gtaacgatgg attcctctgg gacgacatag acgacagcgt 13560 gttttccccg caaccgcaga ccctgctaga gttgcaacag cgcgagcagg cagaggcggc 13620 gctgcgaaag gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc 13680 gcggtcagat gctagtagcc catttccaag cttgataggg tctcttacca gcactcgcac 13740 cacccgcccg cgcctgctgg gcgaggagga gtacctaaac aactcgctgc tgcagccgca 13800 gcgcgaaaaa aacctgcctc cggcatttcc caacaacggg atagagagcc tagtggacaa 13860 gatgagtaga tggaagacgt acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc 13920 cacccgtcgt caaaggcacg accgtcagcg gggtctggtg tgggaggacg atgactcggc 13980 agacgacagc agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc accttcgccc 14040 caggctgggg agaatgtttt aaaaaaaaaa aagcatgatg caaaataaaa aactcaccaa 14100 ggccatggca ccgagcgttg gttttcttgt attcccctta gtatgcggcg cgcggcgatg 14160 tatgaggaag gtcctcctcc ctcctacgag agtgtggtga gcgcggcgcc agtggcggcg 14220 gcgctgggtt ctcccttcga tgctcccctg gacccgccgt ttgtgcctcc gcggtacctg 14280 cggcctaccg gggggagaaa cagcatccgt tactctgagt tggcacccct attcgacacc 14340 acccgtgtgt acctggtgga caacaagtca acggatgtgg catccctgaa ctaccagaac 14400 gaccacagca actttctgac cacggtcatt caaaacaatg actacagccc gggggaggca 14460 agcacacaga ccatcaatct tgacgaccgg tcgcactggg gcggcgacct gaaaaccatc 14520 ctgcatacca acatgccaaa tgtgaacgag ttcatgttta ccaataagtt taaggcgcgg 14580 gtgatggtgt cgcgcttgcc tactaaggac aatcaggtgg agctgaaata cgagtgggtg 14640 gagttcacgc tgcccgaggg caactactcc gagaccatga ccatagacct tatgaacaac 14700 gcgatcgtgg agcactactt gaaagtgggc agacagaacg gggttctgga aagcgacatc 14760 ggggtaaagt ttgacacccg caacttcaga ctggggtttg accccgtcac tggtcttgtc 14820 atgcctgggg tatatacaaa cgaagccttc catccagaca tcattttgct gccaggatgc 14880 ggggtggact tcacccacag ccgcctgagc aacttgttgg gcatccgcaa gcggcaaccc 14940 ttccaggagg gctttaggat cacctacgat gatctggagg gtggtaacat tcccgcactg 15000 ttggatgtgg acgcctacca ggcgagcttg aaagatgaca ccgaacaggg cgggggtggc 15060 gcaggcggca gcaacagcag tggcagcggc gcggaagaga actccaacgc ggcagccgcg 15120 gcaatgcagc cggtggagga catgaacgat catgccattc gcggcgacac ctttgccaca 15180 cgggctgagg agaagcgcgc tgaggccgaa gcagcggccg aagctgccgc ccccgctgcg 15240 caacccgagg tcgagaagcc tcagaagaaa ccggtgatca aacccctgac agaggacagc 15300 aagaaacgca gttacaacct aataagcaat gacagcacct tcacccagta ccgcagctgg 15360 taccttgcat acaactacgg cgaccctcag accggaatcc gctcatggac cctgctttgc 15420 actcctgacg taacctgcgg ctcggagcag gtctactggt cgttgccaga catgatgcaa 15480 gaccccgtga ccttccgctc cacgcgccag atcagcaact ttccggtggt gggcgccgag 15540 ctgttgcccg tgcactccaa gagcttctac aacgaccagg ccgtctactc ccaactcatc 15600 cgccagttta cctctctgac ccacgtgttc aatcgctttc ccgagaacca gattttggcg 15660 cgcccgccag cccccaccat caccaccgtc agtgaaaacg ttcctgctct cacagatcac 15720 gggacgctac cgctgcgcaa cagcatcgga ggagtccagc gagtgaccat tactgacgcc 15780 agacgccgca cctgccccta cgtttacaag gccctgggca tagtctcgcc gcgcgtccta 15840 tcgagccgca ctttttgagc aagcatgtcc atccttatat cgcccagcaa taacacaggc 15900 tggggcctgc gcttcccaag caagatgttt ggcggggcca agaagcgctc cgaccaacac 15960 ccagtgcgcg tgcgcgggca ctaccgcgcg ccctggggcg cgcacaaacg cggccgcact 16020 gggcgcacca ccgtcgatga cgccatcgac gcggtggtgg aggaggcgcg caactacacg 16080 cccacgccgc caccagtgtc cacagtggac gcggccattc agaccgtggt gcgcggagcc 16140 cggcgctatg ctaaaatgaa gagacggcgg aggcgcgtag cacgtcgcca ccgccgccga 16200 cccggcactg ccgcccaacg cgcggcggcg gccctgctta accgcgcacg tcgcaccggc 16260 cgacgggcgg ccatgcgggc cgctcgaagg ctggccgcgg gtattgtcac tgtgcccccc 16320 aggtccaggc gacgagcggc cgccgcagca gccgcggcca ttagtgctat gactcagggt 16380 cgcaggggca acgtgtattg ggtgcgcgac tcggttagcg gcctgcgcgt gcccgtgcgc 16440 acccgccccc cgcgcaacta gattgcaaga aaaaactact tagactcgta ctgttgtatg 16500 tatccagcgg cggcggcgcg caacgaagct atgtccaagc gcaaaatcaa agaagagatg 16560 ctccaggtca tcgcgccgga gatctatggc cccccgaaga aggaagagca ggattacaag 16620 ccccgaaagc taaagcgggt caaaaagaaa aagaaagatg atgatgatga acttgacgac 16680 gaggtggaac tgctgcacgc taccgcgccc aggcgacggg tacagtggaa aggtcgacgc 16740 gtaaaacgtg ttttgcgacc cggcaccacc gtagtcttta cgcccggtga gcgctccacc 16800 cgcacctaca agcgcgtgta tgatgaggtg tacggcgacg aggacctgct tgagcaggcc 16860 aacgagcgcc tcggggagtt tgcctacgga aagcggcata aggacatgct ggcgttgccg 16920 ctggacgagg gcaacccaac acctagccta aagcccgtaa cactgcagca ggtgctgccc 16980 gcgcttgcac cgtccgaaga aaagcgcggc ctaaagcgcg agtctggtga cttggcaccc 17040 accgtgcagc tgatggtacc caagcgccag cgactggaag atgtcttgga aaaaatgacc 17100 gtggaacctg ggctggagcc cgaggtccgc gtgcggccaa tcaagcaggt ggcgccggga 17160 ctgggcgtgc agaccgtgga cgttcagata cccactacca gtagcaccag tattgccacc 17220 gccacagagg gcatggagac acaaacgtcc ccggttgcct cagcggtggc ggatgccgcg 17280 gtgcaggcgg tcgctgcggc cgcgtccaag acctctacgg aggtgcaaac ggacccgtgg 17340 atgtttcgcg tttcagcccc ccggcgcccg cgcggttcga ggaagtacgg cgccgccagc 17400 gcgctactgc ccgaatatgc cctacatcct tccattgcgc ctacccccgg ctatcgtggc 17460 tacacctacc gccccagaag acgagcaact acccgacgcc gaaccaccac tggaacccgc 17520 cgccgccgtc gccgtcgcca gcccgtgctg gccccgattt ccgtgcgcag ggtggctcgc 17580 gaaggaggca ggaccctggt gctgccaaca gcgcgctacc accccagcat cgtttaaaag 17640 ccggtctttg tggttcttgc agatatggcc ctcacctgcc gcctccgttt cccggtgccg 17700 ggattccgag gaagaatgca ccgtaggagg ggcatggccg gccacggcct gacgggcggc 17760 atgcgtcgtg cgcaccaccg gcggcggcgc gcgtcgcacc gtcgcatgcg cggcggtatc 17820 ctgcccctcc ttattccact gatcgccgcg gcgattggcg ccgtgcccgg aattgcatcc 17880 gtggccttgc aggcgcagag acactgatta aaaacaagtt gcatgtggaa aaatcaaaat 17940 aaaaagtctg gactctcacg ctcgcttggt cctgtaacta ttttgtagaa tggaagacat 18000 caactttgcg tctctggccc cgcgacacgg ctcgcgcccg ttcatgggaa actggcaaga 18060 tatcggcacc agcaatatga gcggtggcgc cttcagctgg ggctcgctgt ggagcggcat 18120 taaaaatttc ggttccaccg ttaagaacta tggcagcaag gcctggaaca gcagcacagg 18180 ccagatgctg agggataagt tgaaagagca aaatttccaa caaaaggtgg tagatggcct 18240 ggcctctggc attagcgggg tggtggacct ggccaaccag gcagtgcaaa ataagattaa 18300 cagtaagctt gatccccgcc ctcccgtaga ggagcctcca ccggccgtgg agacagtgtc 18360 tccagagggg cgtggcgaaa agcgtccgcg ccccgacagg gaagaaactc tggtgacgca 18420 aatagacgag cctccctcgt acgaggaggc actaaagcaa ggcctgccca ccacccgtcc 18480 catcgcgccc atggctaccg gagtgctggg ccagcacaca cccgtaacgc tggacctgcc 18540 tccccccgcc gacacccagc agaaacctgt gctgccaggc ccgaccgccg ttgttgtaac 18600 ccgtcctagc cgcgcgtccc tgcgccgcgc cgccagcggt ccgcgatcgt tgcggcccgt 18660 agccagtggc aactggcaaa gcacactgaa cagcatcgtg ggtctggggg tgcaatccct 18720 gaagcgccga cgatgcttct gaatagctaa cgtgtcgtat gtgtgtcatg tatgcgtcca 18780 tgtcgccgcc agaggagctg ctgagccgcc gcgcgcccgc tttccaagat ggctacccct 18840 tcgatgatgc cgcagtggtc ttacatgcac atctcgggcc aggacgcctc ggagtacctg 18900 agccccgggc tggtgcagtt tgcccgcgcc accgagacgt acttcagcct gaataacaag 18960 tttagaaacc ccacggtggc gcctacgcac gacgtgacca cagaccggtc ccagcgtttg 19020 acgctgcggt tcatccctgt ggaccgtgag gatactgcgt actcgtacaa ggcgcggttc 19080 accctagctg tgggtgataa ccgtgtgctg gacatggctt ccacgtactt tgacatccgc 19140 ggcgtgctgg acaggggccc tacttttaag ccctactctg gcactgccta caacgccctg 19200 gctcccaagg gtgccccaaa tccttgcgaa tgggatgaag ctgctactgc tcttgaaata 19260 aacctagaag aagaggacga tgacaacgaa gacgaagtag acgagcaagc tgagcagcaa 19320 aaaactcacg tatttgggca ggcgccttat tctggtataa atattacaaa ggagggtatt 19380 caaataggtg tcgaaggtca aacacctaaa tatgccgata aaacatttca acctgaacct 19440 caaataggag aatctcagtg gtacgaaact gaaattaatc atgcagctgg gagagtcctt 19500 aaaaagacta ccccaatgaa accatgttac ggttcatatg caaaacccac aaatgaaaat 19560 ggagggcaag gcattcttgt aaagcaacaa aatggaaagc tagaaagtca agtggaaatg 19620 caatttttct caactactga ggcgaccgca ggcaatggtg ataacttgac tcctaaagtg 19680 gtattgtaca gtgaagatgt agatatagaa accccagaca ctcatatttc ttacatgccc 19740 actattaagg aaggtaactc acgagaacta atgggccaac aatctatgcc caacaggcct 19800 aattacattg cttttaggga caattttatt ggtctaatgt attacaacag cacgggtaat 19860 atgggtgttc tggcgggcca agcatcgcag ttgaatgctg ttgtagattt gcaagacaga 19920 aacacagagc tttcatacca gcttttgctt gattccattg gtgatagaac caggtacttt 19980 tctatgtgga atcaggctgt tgacagctat gatccagatg ttagaattat tgaaaatcat 20040 ggaactgaag atgaacttcc aaattactgc tttccactgg gaggtgtgat taatacagag 20100 actcttacca aggtaaaacc taaaacaggt caggaaaatg gatgggaaaa agatgctaca 20160 gaattttcag ataaaaatca aataagagtt ggaaataatt ttgccatgga aatcaatcta 20220 aatgccaacc tgtggagaaa tttcctgtac tccaacatag cgctgtattt gcccgacaag 20280 ctaaagtaca gtccttccaa cgtaaaaatt tctgataacc caaacaccta cgactacatg 20340 aacaagcgag tggtggctcc cgggttagtg gactgctaca ttaaccttgg agcacgctgg 20400 tcccttgact atatggacaa cgtcaaccca tttaaccacc accgcaatgc tggcctgcgc 20460 taccgctcaa tgttgctggg caatggtcgc tatgtgccct tccacatcca ggtgcctcag 20520 aagttctttg ccattaaaaa cctccttctc ctgccgggct catacaccta cgagtggaac 20580 ttcaggaagg atgttaacat ggttctgcag agctccctag gaaatgacct aagggttgac 20640 ggagccagca ttaagtttga tagcatttgc ctttacgcca ccttcttccc catggcccac 20700 aacaccgcct ccacgcttga ggccatgctt agaaacgaca ccaacgacca gtcctttaac 20760 gactatctct ccgccgccaa catgctctac cctatacccg ccaacgctac caacgtgccc 20820 atatccatcc cctcccgcaa ctgggcggct ttccgcggct gggccttcac gcgccttaag 20880 actaaggaaa ccccatcact gggctcgggc tacgaccctt attacaccta ctctggctct 20940 ataccctacc tagatggaac cttttacctc aaccacacct ttaagaaggt ggccattacc 21000 tttgactctt ctgtcagctg gcctggcaat gaccgcctgc ttacccccaa cgagtttgaa 21060 attaagcgct cagttgacgg ggagggttac aacgttgccc agtgtaacat gaccaaagac 21120 tggttcctgg tacaaatgct agctaactac aacattggct accagggctt ctatatccca 21180 gagagctaca aggaccgcat gtactccttc tttagaaact tccagcccat gagccgtcag 21240 gtggtggatg atactaaata caaggactac caacaggtgg gcatcctaca ccaacacaac 21300 aactctggat ttgttggcta ccttgccccc accatgcgcg aaggacaggc ctaccctgct 21360 aacttcccct atccgcttat aggcaagacc gcagttgaca gcattaccca gaaaaagttt 21420 ctttgcgatc gcaccctttg gcgcatccca ttctccagta actttatgtc catgggcgca 21480 ctcacagacc tgggccaaaa ccttctctac gccaactccg cccacgcgct agacatgact 21540 tttgaggtgg atcccatgga cgagcccacc cttctttatg ttttgtttga agtctttgac 21600 gtggtccgtg tgcaccggcc gcaccgcggc gtcatcgaaa ccgtgtacct gcgcacgccc 21660 ttctcggccg gcaacgccac aacataaaga agcaagcaac atcaacaaca gctgccgcca 21720 tgggctccag tgagcaggaa ctgaaagcca ttgtcaaaga tcttggttgt gggccatatt 21780 ttttgggcac ctatgacaag cgctttccag gctttgtttc tccacacaag ctcgcctgcg 21840 ccatagtcaa tacggccggt cgcgagactg ggggcgtaca ctggatggcc tttgcctgga 21900 acccgcactc aaaaacatgc tacctctttg agccctttgg cttttctgac cagcgactca 21960 agcaggttta ccagtttgag tacgagtcac tcctgcgccg tagcgccatt gcttcttccc 22020 ccgaccgctg tataacgctg gaaaagtcca cccaaagcgt acaggggccc aactcggccg 22080 cctgtggact attctgctgc atgtttctcc acgcctttgc caactggccc caaactccca 22140 tggatcacaa ccccaccatg aaccttatta ccggggtacc caactccatg ctcaacagtc 22200 cccaggtaca gcccaccctg cgtcgcaacc aggaacagct ctacagcttc ctggagcgcc 22260 actcgcccta cttccgcagc cacagtgcgc agattaggag cgccacttct ttttgtcact 22320 tgaaaaacat gtaaaaataa tgtactagag acactttcaa taaaggcaaa tgcttttatt 22380 tgtacactct cgggtgatta tttaccccca cccttgccgt ctgcgccgtt taaaaatcaa 22440 aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga tactggtgtt 22500 tagtgctcca cttaaactca ggcacaacca tccgcggcag ctcggtgaag ttttcactcc 22560 acaggctgcg caccatcacc aacgcgttta gcaggtcggg cgccgatatc ttgaagtcgc 22620 agttggggcc tccgccctgc gcgcgcgagt tgcgatacac agggttgcag cactggaaca 22680 ctatcagcgc cgggtggtgc acgctggcca gcacgctctt gtcggagatc agatccgcgt 22740 ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt tggtagctgc cttcccaaaa 22800 agggcgcgtg cccaggcttt gagttgcact cgcaccgtag tggcatcaaa aggtgaccgt 22860 gcccggtctg ggcgttagga tacagcgcct gcataaaagc cttgatctgc ttaaaagcca 22920 cctgagcctt tgcgccttca gagaagaaca tgccgcaaga cttgccggaa aactgattgg 22980 ccggacaggc cgcgtcgtgc acgcagcacc ttgcgtcggt gttggagatc tgcaccacat 23040 ttcggcccca ccggttcttc acgatcttgg ccttgctaga ctgctccttc agcgcgcgct 23100 gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc cttatttatc ataatgcttc 23160 cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg gtgcagccac aacgcgcagc 23220 ccgtgggctc gtgatgcttg taggtcacct ctgcaaacga ctgcaggtac gcctgcagga 23280 atcgccccat catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc aacccgcggt 23340 gctcctcgtt cagccaggtc ttgcatacgg ccgccagagc ttccacttgg tcaggcagta 23400 gtttgaagtt cgcctttaga tcgttatcca cgtggtactt gtccatcagc gcgcgcgcag 23460 cctccatgcc cttctcccac gcagacacga tcggcacact cagcgggttc atcaccgtaa 23520 tttcactttc cgcttcgctg ggctcttcct cttcctcttg cgtccgcata ccacgcgcca 23580 ctgggtcgtc ttcattcagc cgccgcactg tgcgcttacc tcctttgcca tgcttgatta 23640 gcaccggtgg gttgctgaaa cccaccattt gtagcgccac atcttctctt tcttcctcgc 23700 tgtccacgat tacctctggt gatggcgggc gctcgggctt gggagaaggg cgcttctttt 23760 tcttcttggg cgcaatggcc aaatccgccg ccgaggtcga tggccgcggg ctgggtgtgc 23820 gcggcaccag cgcgtcttgt gatgagtctt cctcgtcctc ggactcgata cgccgcctca 23880 tccgcttttt tgggggcgcc cggggaggcg gcggcgacgg ggacggggac gacacgtcct 23940 ccatggttgg gggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt tcgcgctgct 24000 cctcttcccg actggccatt tccttctcct ataggcagaa aaagatcatg gagtcagtcg 24060 agaagaagga cagcctaacc gccccctctg agttcgccac caccgcctcc accgatgccg 24120 ccaacgcgcc taccaccttc cccgtcgagg cacccccgct tgaggaggag gaagtgatta 24180 tcgagcagga cccaggtttt gtaagcgaag acgacgagga ccgctcagta ccaacagagg 24240 ataaaaagca agaccaggac aacgcagagg caaacgagga acaagtcggg cggggggacg 24300 aaaggcatgg cgactaccta gatgtgggag acgacgtgct gttgaagcat ctgcagcgcc 24360 agtgcgccat tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc gccatagcgg 24420 atgtcagcct tgcctacgaa cgccacctat tctcaccgcg cgtacccccc aaacgccaag 24480 aaaacggcac atgcgagccc aacccgcgcc tcaacttcta ccccgtattt gccgtgccag 24540 aggtgcttgc cacctatcac atctttttcc aaaactgcaa gataccccta tcctgccgtg 24600 ccaaccgcag ccgagcggac aagcagctgg ccttgcggca gggcgctgtc atacctgata 24660 tcgcctcgct caacgaagtg ccaaaaatct ttgagggtct tggacgcgac gagaagcgcg 24720 cggcaaacgc tctgcaacag gaaaacagcg aaaatgaaag tcactctgga gtgttggtgg 24780 aactcgaggg tgacaacgcg cgcctagccg tactaaaacg cagcatcgag gtcacccact 24840 ttgcctaccc ggcacttaac ctacccccca aggtcatgag cacagtcatg agtgagctga 24900 tcgtgcgccg tgcgcagccc ctggagaggg atgcaaattt gcaagaacaa acagaggagg 24960 gcctacccgc agttggcgac gagcagctag cgcgctggct tcaaacgcgc gagcctgccg 25020 acttggagga gcgacgcaaa ctaatgatgg ccgcagtgct cgttaccgtg gagcttgagt 25080 gcatgcagcg gttctttgct gacccggaga tgcagcgcaa gctagaggaa acattgcact 25140 acacctttcg acagggctac gtacgccagg cctgcaagat ctccaacgtg gagctctgca 25200 acctggtctc ctaccttgga attttgcacg aaaaccgcct tgggcaaaac gtgcttcatt 25260 ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac ttatttctat 25320 gctacacctg gcagacggcc atgggcgttt ggcagcagtg cttggaggag tgcaacctca 25380 aggagctgca gaaactgcta aagcaaaact tgaaggacct atggacggcc ttcaacgagc 25440 gctccgtggc cgcgcacctg gcggacatca ttttccccga acgcctgctt aaaaccctgc 25500 aacagggtct gccagacttc accagtcaaa gcatgttgca gaactttagg aactttatcc 25560 tagagcgctc aggaatcttg cccgccacct gctgtgcact tcctagcgac tttgtgccca 25620 ttaagtaccg cgaatgccct ccgccgcttt ggggccactg ctaccttctg cagctagcca 25680 actaccttgc ctaccactct gacataatgg aagacgtgag cggtgacggt ctactggagt 25740 gtcactgtcg ctgcaaccta tgcaccccgc accgctccct ggtttgcaat tcgcagctgc 25800 ttaacgaaag tcaaattatc ggtacctttg agctgcaggg tccctcgcct gacgaaaagt 25860 ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac gtcggcttac cttcgcaaat 25920 ttgtacctga ggactaccac gcccacgaga ttaggttcta cgaagaccaa tcccgcccgc 25980 caaatgcgga gcttaccgcc tgcgtcatta cccagggcca cattcttggc caattgcaag 26040 ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg acggggggtt tacttggacc 26100 cccagtccgg cgaggagctc aacccaatcc ccccgccgcc gcagccctat cagcagcagc 26160 cgcgggccct tgcttcccag gatggcaccc aaaaagaagc tgcagctgcc gccgccaccc 26220 acggacgagg aggaatactg ggacagtcag gcagaggagg ttttggacga ggaggaggag 26280 gacatgatgg aagactggga gagcctagac gaggaagctt ccgaggtcga agaggtgtca 26340 gacgaaacac cgtcaccctc ggtcgcattc ccctcgccgg cgccccagaa atcggcaacc 26400 ggttccagca tggctacaac ctccgctcct caggcgccgc cggcactgcc cgttcgccga 26460 cccaaccgta gatgggacac cactggaacc agggccggta agtccaagca gccgccgccg 26520 ttagcccaag agcaacaaca gcgccaaggc taccgctcat ggcgcgggca caagaacgcc 26580 atagttgctt gcttgcaaga ctgtgggggc aacatctcct tcgcccgccg ctttcttctc 26640 taccatcacg gcgtggcctt cccccgtaac atcctgcatt actaccgtca tctctacagc 26700 ccatactgca ccggcggcag cggcagcggc agcaacagca gcggccacac agaagcaaag 26760 gcgaccggat agcaagactc tgacaaagcc caagaaatcc acagcggcgg cagcagcagg 26820 aggaggagcg ctgcgtctgg cgcccaacga acccgtatcg acccgcgagc ttagaaacag 26880 gatttttccc actctgtatg ctatatttca acagagcagg ggccaagaac aagagctgaa 26940 aataaaaaac aggtctctgc gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga 27000 tcagcttcgg cgcacgctgg aagacgcgga ggctctcttc agtaaatact gcgcgctgac 27060 tcttaaggac tagtttcgcg ccctttctca aatttaagcg cgaaaactac gtcatctcca 27120 gcggccacac ccggcgccag cacctgtcgt cagcgccatt tatgagcaag gaaattccca 27180 cgccctacat gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact 27240 actcaacccg aataaactac atgagcgcgg gaccccacat gatatcccgg gtcaacggaa 27300 tacgcgccca ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta 27360 ataaccttaa tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca 27420 ccactgtggt acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc 27480 agcttgcggg cggctttcgt cacagggtgc ggtcgcccgg gcagggtata actcacctga 27540 caatcagagg gcgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc 27600 gtccggacgg gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg 27660 caatcctaac tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactctgc 27720 aatttattga ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc 27780 actatccgga tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg 27840 actgaatgtt aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc 27900 gccacaagtg ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc 27960 atatcgaggg cccggcgcac ggcgtccggc ttaccgccca gggagagctt gcccgtagcc 28020 tgattcggga gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc 28080 tcactgtgat ttgcaactgt cctaaccctg gattacatca agatctttgt tgccatctct 28140 gtgctgagta taataaatac agaaattaaa atatactggg gctcctatcg ccatcctgta 28200 aacgccaccg tcttcacccg cccaagcaaa ccaaggcgaa ccttacctgg tacttttaac 28260 atctctccct ctgtgattta caacagtttc aacccagacg gagtgagtct acgagagaac 28320 ctctccgagc tcagctactc catcagaaaa aacaccaccc tccttacctg ccgggaacgt 28380 acgagtgcgt caccggccgc tgcaccacac ctaccgcctg accgtaaacc agactttttc 28440 cggacagacc tcaataactc tgtttaccag aacaggaggt gagcttagaa aacccttagg 28500 gtattaggcc aaaggcgcag ctactgtggg gtttatgaac aattcaagca actctacggg 28560 ctattctaat tcaggtttct ctagaatcgg ggttggggtt attctctgtc ttgtgattct 28620 ctttattctt atactaacgc ttctctgcct aaggctcgcc gcctgctgtg tgcacatttg 28680 catttattgt cagcttttta aacgctgggg tcgccaccca agatgattag gtacataatc 28740 ctaggtttac tcacccttgc gtcagcccac ggtaccaccc aaaaggtgga ttttaaggag 28800 ccagcctgta atgttacatt cgcagctgaa gctaatgagt gcaccactct tataaaatgc 28860 accacagaac atgaaaagct gcttattcgc cacaaaaaca aaattggcaa gtatgctgtt 28920 tatgctattt ggcagccagg tgacactaca gagtataatg ttacagtttt ccagggtaaa 28980 agtcataaaa cttttatgta tacttttcca ttttatgaaa tgtgcgacat taccatgtac 29040 atgagcaaac agtataagtt gtggccccca caaaattgtg tggaaaacac tggcactttc 29100 tgctgcactg ctatgctaat tacagtgctc gctttggtct gtaccctact ctatattaaa 29160 tacaaaagca gacgcagctt tattgaggaa aagaaaatgc cttaatttac taagttacaa 29220 agctaatgtc accactaact gctttactcg ctgcttgcaa aacaaattca aaaagttagc 29280 attataatta gaataggatt taaacccccc ggtcatttcc tgctcaatac cattcccctg 29340 aacaattgac tctatgtggg atatgctcca gcgctacaac cttgaagtca ggcttcctgg 29400 atgtcagcat ctgactttgg ccagcacctg tcccgcggat ttgttccagt ccaactacag 29460 cgacccaccc taacagagat gaccaacaca accaacgcgg ccgccgctac cggacttaca 29520 tctaccacaa atacacccca agtttctgcc tttgtcaata actgggataa cttgggcatg 29580 tggtggttct ccatagcgct tatgtttgta tgccttatta ttatgtggct catctgctgc 29640 ctaaagcgca aacgcgcccg accacccatc tatagtccca tcattgtgct acacccaaac 29700 aatgatggaa tccatagatt ggacggactg aaacacatgt tcttttctct tacagtatga 29760 ttaaatgaga catgattcct cgagttttta tattactgac ccttgttgcg cttttttgtg 29820 cgtgctccac attggctgcg gtttctcaca tcgaagtaga ctgcattcca gccttcacag 29880 tctatttgct ttacggattt gtcaccctca cgctcatctg cagcctcatc actgtggtca 29940 tcgcctttat ccagtgcatt gactgggtct gtgtgcgctt tgcatatctc agacaccatc 30000 cccagtacag ggacaggact atagctgagc ttcttagaat tctttaatta tgaaatttac 30060 tgtgactttt ctgctgatta tttgcaccct atctgcgttt tgttccccga cctccaagcc 30120 tcaaagacat atatcatgca gattcactcg tatatggaat attccaagtt gctacaatga 30180 aaaaagcgat ctttccgaag cctggttata tgcaatcatc tctgttatgg tgttctgcag 30240 taccatctta gccctagcta tatatcccta ccttgacatt ggctggaacg caatagatgc 30300 catgaaccac ccaactttcc ccgcgcccgc tatgcttcca ctgcaacaag ttgttgccgg 30360 cggctttgtc ccagccaatc agcctcgccc accttctccc acccccactg aaatcagcta 30420 ctttaatcta acaggaggag atgactgaca ccctagatct agaaatggac ggaattatta 30480 cagagcagcg cctgctagaa agacgcaggg cagcggccga gcaacagcgc atgaatcaag 30540 agctccaaga catggttaac ttgcaccagt gcaaaagggg tatcttttgt ctggtaaagc 30600 aggccaaagt cacctacgac agtaatacca ccggacaccg ccttagctac aagttgccaa 30660 ccaagcgtca gaaattggtg gtcatggtgg gagaaaagcc cattaccata actcagcact 30720 cggtagaaac cgaaggctgc attcactcac cttgtcaagg acctgaggat ctctgcaccc 30780 ttattaagac cctgtgcggt ctcaaagatc ttattccctt taactaataa aaaaaaataa 30840 taaagcatca cttacttaaa atcagttagc aaatttctgt ccagtttatt cagcagcacc 30900 tccttgccct cctcccagct ctggtattgc agcttcctcc tggctgcaaa ctttctccac 30960 aatctaaatg gaatgtcagt ttcctcctgt tcctgtccat ccgcacccac tatcttcatg 31020 ttgttgcaga tgaagcgcgc aagaccgtct gaagatacct tcaaccccgt gtatccatat 31080 gacacggaaa ccggtcctcc aactgtgcct tttcttactc ctccctttgt atcccccaat 31140 gggtttcaag agagtccccc tggggtactc tctttgcgcc tatccgaacc tctagttacc 31200 tccaatggca tgcttgcgct caaaatgggc aacggcctct ctctggacga ggccggcaac 31260 cttacctccc aaaatgtaac cactgtgagc ccacctctca aaaaaaccaa gtcaaacata 31320 aacctggaaa tatctgcacc cctcacagtt acctcagaag ccctaactgt ggctgccgcc 31380 gcacctctaa tggtcgcggg caacacactc accatgcaat cacaggcccc gctaaccgtg 31440 cacgactcca aacttagcat tgccacccaa ggacccctca cagtgtcaga aggaaagcta 31500 gccctgcaaa catcaggccc cctcaccacc accgatagca gtacccttac tatcactgcc 31560 tcaccccctc taactactgc cactggtagc ttgggcattg acttgaaaga gcccatttat 31620 acacaaaatg gaaaactagg actaaagtac ggggctcctt tgcatgtaac agacgaccta 31680 aacactttga ccgtagcaac tggtccaggt gtgactatta ataatacttc cttgcaaact 31740 aaagttactg gagccttggg ttttgattca caaggcaata tgcaacttaa tgtagcagga 31800 ggactaagga ttgattctca aaacagacgc cttatacttg atgttagtta tccgtttgat 31860 gctcaaaacc aactaaatct aagactagga cagggccctc tttttataaa ctcagcccac 31920 aacttggata ttaactacaa caaaggcctt tacttgttta cagcttcaaa caattccaaa 31980 aagcttgagg ttaacctaag cactgccaag gggttgatgt ttgacgctac agccatagcc 32040 attaatgcag gagatgggct tgaatttggt tcacctaatg caccaaacac aaatcccctc 32100 aaaacaaaaa ttggccatgg cctagaattt gattcaaaca aggctatggt tcctaaacta 32160 ggaactggcc ttagttttga cagcacaggt gccattacag taggaaacaa aaataatgat 32220 aagctaactt tatggacagg agtcaacccc accgaagcca actgtcaaat catgaactcc 32280 agtgaatcta atgattgcaa attaattcta acactagtta aaactggagc actagtcact 32340 gcatttgttt atgttatagg agtatctaac aattttaata tgctaactac acacagaaat 32400 ataaatttta ctgcagagct gtttttcgat tctactggta atttactaac tagactctca 32460 tccctcaaaa ctccacttaa tcataaatca ggacaaaaca tggctactgg tgccattact 32520 aatgctaaag gtttcatgcc cagcacgact gcctatcctt tcaatgataa ttctagagaa 32580 aaagaaaact acatttacgg aacttgttac tacacagcta gtgatcgcac tgcttttccc 32640 attgacatat ctgtcatgct taaccgaaga gcaataaatg acgagacatc atattgtatt 32700 cgtataactt ggtcctggaa cacaggagat gccccagagg tgcaaacctc tgctacaacc 32760 ctagtcacct ccccatttac cttttactac atcagagaag acgactaata aagaatcgtt 32820 tgtgttatgt ttcaacgtgt ttatttttca attgcagaaa atttcaagtc atttttcatt 32880 cagtagtata gccccaccac cacatagctt atacagatca ccgtacctta atcaaaccta 32940 catgggggta gagtcataat cgtgcatcag gatagggcgg tggtgctgca gcagcgcgcg 33000 aataaactgc tgccgccgcc gctccgtcct gcaggaatac aacatggcag tggtctcctc 33060 agcgatgatt cgcaccgccc gcagcataag gcgccttgtc ctccgggcac agcagcgcac 33120 cctgatctca cttaaatcag cacagtaact gcagcacagc accacaatat tgttcaaaat 33180 cccacagtgc aaggcgctgt atccaaagct catggcgggg accacagaac ccacgtggcc 33240 atcataccac aagcgcaggt agattaagtg gcgacccctc ataaacacgc tggacataaa 33300 cattacctct tttggcatgt tgtaattcac cacctcccgg taccatataa acctctgatt 33360 aaacatggcg ccatccacca ccatcctaaa ccagctggcc aaaacctgcc cgccggctat 33420 acactgcagg gaaccgggac tggaacaatg acagtggaga gcccaggact cgtaaccatg 33480 gatcatcatg ctcgtcatga tatcaatgtt ggcacaacac aggcacacgt gcatacactt 33540 cctcaggatt acaagctcct cccgcgttag aaccatatcc cagggaacaa cccattcctg 33600 aatcagcgta aatcccacac tgcagggaag acctcgcacg taactcacgt tgtgcattgt 33660 caaagtgtta cattcgggca gcagcggatg atcctccagt atggtagcgc gggtttctgt 33720 ctcaaaagga ggtagacgat ccctactgta cggagtgcgc cgagacaacc gagatcgtgt 33780 tggtcgtagt gtcatgccaa atggaacgcc ggacgtagtc atatttcctg aagcaaaacc 33840 aggtgcgggc gtgacaaaca gatctgcgtc tccggtctcg ccgcttagat cgctctgtgt 33900 agtagttgta gtatatccac tctctcaaag catccaggcg ccccctggct tcgggttcta 33960 tgtaaactcc ttcatgcgcc gctgccctga taacatccac caccgcagaa taagccacac 34020 ccagccaacc tacacattcg ttctgcgagt cacacacggg aggagcggga agagctggaa 34080 gaaccatgtt ttttttttta ttccaaaaga ttatccaaaa cctcaaaatg aagatctatt 34140 aagtgaacgc gctcccctcc ggtggcgtgg tcaaactcta cagccaaaga acagataatg 34200 gcatttgtaa gatgttgcac aatggcttcc aaaaggcaaa cggccctcac gtccaagtgg 34260 acgtaaaggc taaacccttc agggtgaatc tcctctataa acattccagc accttcaacc 34320 atgcccaaat aattctcatc tcgccacctt ctcaatatat ctctaagcaa atcccgaata 34380 ttaagtccgg ccattgtaaa aatctgctcc agagcgccct ccaccttcag cctcaagcag 34440 cgaatcatga ttgcaaaaat tcaggttcct cacagacctg tataagattc aaaagcggaa 34500 cattaacaaa aataccgcga tcccgtaggt cccttcgcag ggccagctga acataatcgt 34560 gcaggtctgc acggaccagc gcggccactt ccccgccagg aaccatgaca aaagaaccca 34620 cactgattat gacacgcata ctcggagcta tgctaaccag cgtagccccg atgtaagctt 34680 gttgcatggg cggcgatata aaatgcaagg tgctgctcaa aaaatcaggc aaagcctcgc 34740 gcaaaaaaga aagcacatcg tagtcatgct catgcagata aaggcaggta agctccggaa 34800 ccaccacaga aaaagacacc atttttctct caaacatgtc tgcgggtttc tgcataaaca 34860 caaaataaaa taacaaaaaa acatttaaac attagaagcc tgtcttacaa caggaaaaac 34920 aacccttata agcataagac ggactacggc catgccggcg tgaccgtaaa aaaactggtc 34980 accgtgatta aaaagcacca ccgacagctc ctcggtcatg tccggagtca taatgtaaga 35040 ctcggtaaac acatcaggtt gattcacatc ggtcagtgct aaaaagcgac cgaaatagcc 35100 cgggggaata catacccgca ggcgtagaga caacattaca gcccccatag gaggtataac 35160 aaaattaata ggagagaaaa acacataaac acctgaaaaa ccctcctgcc taggcaaaat 35220 agcaccctcc cgctccagaa caacatacag cgcttccaca gcggcagcca taacagtcag 35280 ccttaccagt aaaaaagaaa acctattaaa aaaacaccac tcgacacggc accagctcaa 35340 tcagtcacag tgtaaaaaag ggccaagtgc agagcgagta tatataggac taaaaaatga 35400 cgtaacggtt aaagtccaca aaaaacaccc agaaaaccgc acgcgaacct acgcccagaa 35460 acgaaagcca aaaaacccac aacttcctca aatcgtcact tccgttttcc cacgttacgt 35520 cacttcccat tttaagaaaa ctacaattcc caacacatac aagttactcc gccctaaaac 35580 ctacgtcacc cgccccgttc ccacgccccg cgccacgtca caaactccac cccctcatta 35640 tcatattggc ttcaatccaa aataaggtat attattgatg atg 35683 <210> 84 <211> 35647 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO509 <400> 84 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagca taagtgtctt gctgtcttta 4080 tttaggggtt ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct 4140 gtgtattttt tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag 4200 cccgtctctg gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta 4260 gatgatccag tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa 4320 gctgattgcc aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg 4380 gtgcatacgt ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc 4440 agccatatcc ctccggggat tcatgttgtg cagaaccacc agcacagtgt atccggtgca 4500 cttgggaaat ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt 4560 gtgacctcca agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc 4620 ggcctgggcg aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc 4680 gtcataggcc atttttacaa agcgcgggcg gagggtgcca gactgcggta taatggttcc 4740 atccggccca ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga 4800 tggggggatc atgtctacct gcggggcgat gaagaaaacg gtttccgggg taggggagat 4860 cagctgggaa gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta 4920 aatcacacct attaccgggt gcaactggta gttaagagag ctgcagctgc cgtcatccct 4980 gagcaggggg gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc 5040 cgccagaagg cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa 5100 cggtttgaga ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg 5160 gtcccacagc tcggtcacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc 5220 gggttggggc ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc 5280 atgtctttcc acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc 5340 gctccgggct gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc 5400 tgccggtctt cgccctgcgc gtcggccagg tagcatttga ccatggtgtc atagtccagc 5460 ccctccgcgg cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg 5520 cagtgcagac ttttgagggc gtagagcttg ggcgcgagaa ataccgattc cggggagtag 5580 gcatccgcgc cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc 5640 cgttcggggt caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt 5700 tccatgagcc ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac 5760 ttgagaggcc tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac 5820 tctgagacaa aggctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg 5880 tcgttgtcca ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg 5940 gcatcaagga aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg 6000 gggctataaa agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg 6060 agggccagct gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga 6120 ttgtcagttt ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg 6180 agggtggccg catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca 6240 aacgacccgt agagggcgtt ggacagcaac ttggcgatgg agcgcagggt ttggtttttg 6300 tcgcgatcgg cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac 6360 cgccattcgg gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg 6420 ttgtgcaggg tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc 6480 cagcagaggc ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg 6540 tccggggggt ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct 6600 atcttgcatc cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg 6660 tatgggttga gtgggggacc ccatggcatg gggtgggtga gcgcggaggc gtacatgccg 6720 caaatgtcgt aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt 6780 ccaccgcgga tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg 6840 ggaccgaggt tgctacgggc gggctgctct gctcggaaga ctatctgcct gaagatggca 6900 tgtgagttgg atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct 6960 accgcgtcac gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg 7020 acctgcacgt ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt 7080 cccttttttt tccacagctc gcggttgagg acaaactctt cgcggtcttt ccagtactct 7140 tggatcggaa acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg 7200 gcctggtagg cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg 7260 agcgaggtgt gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg 7320 aagtcagtgt cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa 7380 cgcggatttg gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata 7440 aagttgcgtg tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg 7500 gcgagcacga tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag ttccaagaag 7560 cgcgggatgc ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg 7620 gagctgagcc cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat 7680 gagctccaca ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg 7740 cgacctatgg ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag 7800 cggtcccatc caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg 7860 ccgaacttca tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta 7920 taggtctcta catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg 7980 aagaactgga tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag 8040 tccctgcgac gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag 8100 cggtgcacgg gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag 8160 agtgggaatt tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct 8220 tgtccttgac cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc 8280 gagcccaaag tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga 8340 tgggagctgt ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg 8400 tttacctcgc atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg 8460 ggctggttgg tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg 8520 gtaccgcgcg gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt 8580 gacgcgggcg agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg 8640 gcacgtcggc gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg 8700 cgacgacgcg gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg 8760 tgagcttgag cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct 8820 ggcgcaaaat ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact 8880 gctcgatctc ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt 8940 cgttggaaat gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc 9000 ggctgtagac cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga 9060 gctccacgtg ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg 9120 tggtggcggt gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt 9180 tgatatcccc caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga 9240 aaaactggga gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg 9300 cgacagtgtc gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct 9360 cctcttccat aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac 9420 ggcggcgacg acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc 9480 gacggcgcat ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc 9540 cgcccgtcat gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc 9600 taacgatgca tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt 9660 ccgcatcgac cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag 9720 gtaggctgag caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg 9780 tgctgctgat gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca 9840 ccatgtcctt gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt 9900 tttgacatcg gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt 9960 cttctccttc ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg 10020 gccgtaggtg gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa 10080 gcagggctag gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg 10140 tagactggaa gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag 10200 tgcagttggc cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt 10260 acctgagacg cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt 10320 actggtatcc caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg 10380 ccggggctcc gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg 10440 acatccaggt gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc 10500 agatgttgcg cagcggcaaa aagtgctcca tggtcgggac gctctggccg gtcaggcgcg 10560 cgcaatcgtt gacgctctag accgtgcaaa aggagagcct gtaagcgggc actcttccgt 10620 ggtctggtgg ataaattcgc aagggtatca tggcggacga ccggggttcg agccccgtat 10680 ccggccgtcc gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg 10740 tcagacaacg ggggagtgct ccttttggct tccttccagg cgcggcggct gctgcgctag 10800 cttttttggc cactggccgc gcgcagcgta agcggttagg ctggaaagcg aaagcattaa 10860 gtggctcgct ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg ggacccccgg 10920 ttcgagtctc ggaccggccg gactgcggcg aacgggggtt tgcctccccg tcatgcaaga 10980 ccccgcttgc aaattcctcc ggaaacaggg acgagcccct tttttgcttt tcccagatgc 11040 atccggtgct gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc 11100 agacatgcag ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca tccgcggttg 11160 acgcggcagc agatggtgat tacgaacccc cgcggcgccg ggcccggcac tacctggact 11220 tggaggaggg cgagggcctg gcgcggctag gagcgccctc tcctgagcgg tacccaaggg 11280 tgcagctgaa gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc 11340 gcgagggaga ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc 11400 ggcatggcct gaatcgcgag cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa 11460 ccgggattag tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc gcatacgagc 11520 agacggtgaa ccaggagatt aactttcaaa aaagctttaa caaccacgtg cgtacgcttg 11580 tggcgcgcga ggaggtggct ataggactga tgcatctgtg ggactttgta agcgcgctgg 11640 agcaaaaccc aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg cagcacagca 11700 gggacaacga ggcattcagg gatgcgctgc taaacatagt agagcccgag ggccgctggc 11760 tgctcgattt gataaacatc ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg 11820 ctgacaaggt ggccgccatc aactattcca tgcttagcct gggcaagttt tacgcccgca 11880 agatatacca taccccttac gttcccatag acaaggaggt aaagatcgag gggttctaca 11940 tgcgcatggc gctgaaggtg cttaccttga gcgacgacct gggcgtttat cgcaacgagc 12000 gcatccacaa ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc 12060 acagcctgca aagggccctg gctggcacgg gcagcggcga tagagaggcc gagtcctact 12120 ttgacgcggg cgctgacctg cgctgggccc caagccgacg cgccctggag gcagctgggg 12180 ccggacctgg gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat 12240 atgacgagga cgatgagtac gagccagagg acggcgagta ctaagcggtg atgtttctga 12300 tcagatgatg caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc 12360 cggccttaac tccacggacg actggcgcca ggtcatggac cgcatcatgt cgctgactgc 12420 gcgcaatcct gacgcgttcc ggcagcagcc gcaggccaac cggctctccg caattctgga 12480 agcggtggtc ccggcgcgcg caaaccccac gcacgagaag gtgctggcga tcgtaaacgc 12540 gctggccgaa aacagggcca tccggcccga cgaggccggc ctggtctacg acgcgctgct 12600 tcagcgcgtg gctcgttaca acagcggcaa cgtgcagacc aacctggacc ggctggtggg 12660 ggatgtgcgc gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca acctgggctc 12720 catggttgca ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc ggggacagga 12780 ggactacacc aactttgtga gcgcactgcg gctaatggtg actgagacac cgcaaagtga 12840 ggtgtaccag tctgggccag actatttttt ccagaccagt agacaaggcc tgcagaccgt 12900 aaacctgagc caggctttca aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg 12960 cgaccgcgcg accgtgtcta gcttgctgac gcccaactcg cgcctgttgc tgctgctaat 13020 agcgcccttc acggacagtg gcagcgtgtc ccgggacaca tacctaggtc acttgctgac 13080 actgtaccgc gaggccatag gtcaggcgca tgtggacgag catactttcc aggagattac 13140 aagtgtcagc cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa ccctaaacta 13200 cctgctgacc aaccggcggc agaagatccc ctcgttgcac agtttaaaca gcgaggagga 13260 gcgcattttg cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg acggggtaac 13320 gcccagcgtg gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa 13380 ccggccgttt atcaaccgcc taatggacta cttgcatcgc gcggccgccg tgaaccccga 13440 gtatttcacc aatgccatct tgaacccgca ctggctaccg ccccctggtt tctacaccgg 13500 gggattcgag gtgcccgagg gtaacgatgg attcctctgg gacgacatag acgacagcgt 13560 gttttccccg caaccgcaga ccctgctaga gttgcaacag cgcgagcagg cagaggcggc 13620 gctgcgaaag gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc 13680 gcggtcagat gctagtagcc catttccaag cttgataggg tctcttacca gcactcgcac 13740 cacccgcccg cgcctgctgg gcgaggagga gtacctaaac aactcgctgc tgcagccgca 13800 gcgcgaaaaa aacctgcctc cggcatttcc caacaacggg atagagagcc tagtggacaa 13860 gatgagtaga tggaagacgt acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc 13920 cacccgtcgt caaaggcacg accgtcagcg gggtctggtg tgggaggacg atgactcggc 13980 agacgacagc agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc accttcgccc 14040 caggctgggg agaatgtttt aaaaaaaaaa aagcatgatg caaaataaaa aactcaccaa 14100 ggccatggca ccgagcgttg gttttcttgt attcccctta gtatgcggcg cgcggcgatg 14160 tatgaggaag gtcctcctcc ctcctacgag agtgtggtga gcgcggcgcc agtggcggcg 14220 gcgctgggtt ctcccttcga tgctcccctg gacccgccgt ttgtgcctcc gcggtacctg 14280 cggcctaccg gggggagaaa cagcatccgt tactctgagt tggcacccct attcgacacc 14340 acccgtgtgt acctggtgga caacaagtca acggatgtgg catccctgaa ctaccagaac 14400 gaccacagca actttctgac cacggtcatt caaaacaatg actacagccc gggggaggca 14460 agcacacaga ccatcaatct tgacgaccgg tcgcactggg gcggcgacct gaaaaccatc 14520 ctgcatacca acatgccaaa tgtgaacgag ttcatgttta ccaataagtt taaggcgcgg 14580 gtgatggtgt cgcgcttgcc tactaaggac aatcaggtgg agctgaaata cgagtgggtg 14640 gagttcacgc tgcccgaggg caactactcc gagaccatga ccatagacct tatgaacaac 14700 gcgatcgtgg agcactactt gaaagtgggc agacagaacg gggttctgga aagcgacatc 14760 ggggtaaagt ttgacacccg caacttcaga ctggggtttg accccgtcac tggtcttgtc 14820 atgcctgggg tatatacaaa cgaagccttc catccagaca tcattttgct gccaggatgc 14880 ggggtggact tcacccacag ccgcctgagc aacttgttgg gcatccgcaa gcggcaaccc 14940 ttccaggagg gctttaggat cacctacgat gatctggagg gtggtaacat tcccgcactg 15000 ttggatgtgg acgcctacca ggcgagcttg aaagatgaca ccgaacaggg cgggggtggc 15060 gcaggcggca gcaacagcag tggcagcggc gcggaagaga actccaacgc ggcagccgcg 15120 gcaatgcagc cggtggagga catgaacgat catgccattc gcggcgacac ctttgccaca 15180 cgggctgagg agaagcgcgc tgaggccgaa gcagcggccg aagctgccgc ccccgctgcg 15240 caacccgagg tcgagaagcc tcagaagaaa ccggtgatca aacccctgac agaggacagc 15300 aagaaacgca gttacaacct aataagcaat gacagcacct tcacccagta ccgcagctgg 15360 taccttgcat acaactacgg cgaccctcag accggaatcc gctcatggac cctgctttgc 15420 actcctgacg taacctgcgg ctcggagcag gtctactggt cgttgccaga catgatgcaa 15480 gaccccgtga ccttccgctc cacgcgccag atcagcaact ttccggtggt gggcgccgag 15540 ctgttgcccg tgcactccaa gagcttctac aacgaccagg ccgtctactc ccaactcatc 15600 cgccagttta cctctctgac ccacgtgttc aatcgctttc ccgagaacca gattttggcg 15660 cgcccgccag cccccaccat caccaccgtc agtgaaaacg ttcctgctct cacagatcac 15720 gggacgctac cgctgcgcaa cagcatcgga ggagtccagc gagtgaccat tactgacgcc 15780 agacgccgca cctgccccta cgtttacaag gccctgggca tagtctcgcc gcgcgtccta 15840 tcgagccgca ctttttgagc aagcatgtcc atccttatat cgcccagcaa taacacaggc 15900 tggggcctgc gcttcccaag caagatgttt ggcggggcca agaagcgctc cgaccaacac 15960 ccagtgcgcg tgcgcgggca ctaccgcgcg ccctggggcg cgcacaaacg cggccgcact 16020 gggcgcacca ccgtcgatga cgccatcgac gcggtggtgg aggaggcgcg caactacacg 16080 cccacgccgc caccagtgtc cacagtggac gcggccattc agaccgtggt gcgcggagcc 16140 cggcgctatg ctaaaatgaa gagacggcgg aggcgcgtag cacgtcgcca ccgccgccga 16200 cccggcactg ccgcccaacg cgcggcggcg gccctgctta accgcgcacg tcgcaccggc 16260 cgacgggcgg ccatgcgggc cgctcgaagg ctggccgcgg gtattgtcac tgtgcccccc 16320 aggtccaggc gacgagcggc cgccgcagca gccgcggcca ttagtgctat gactcagggt 16380 cgcaggggca acgtgtattg ggtgcgcgac tcggttagcg gcctgcgcgt gcccgtgcgc 16440 acccgccccc cgcgcaacta gattgcaaga aaaaactact tagactcgta ctgttgtatg 16500 tatccagcgg cggcggcgcg caacgaagct atgtccaagc gcaaaatcaa agaagagatg 16560 ctccaggtca tcgcgccgga gatctatggc cccccgaaga aggaagagca ggattacaag 16620 ccccgaaagc taaagcgggt caaaaagaaa aagaaagatg atgatgatga acttgacgac 16680 gaggtggaac tgctgcacgc taccgcgccc aggcgacggg tacagtggaa aggtcgacgc 16740 gtaaaacgtg ttttgcgacc cggcaccacc gtagtcttta cgcccggtga gcgctccacc 16800 cgcacctaca agcgcgtgta tgatgaggtg tacggcgacg aggacctgct tgagcaggcc 16860 aacgagcgcc tcggggagtt tgcctacgga aagcggcata aggacatgct ggcgttgccg 16920 ctggacgagg gcaacccaac acctagccta aagcccgtaa cactgcagca ggtgctgccc 16980 gcgcttgcac cgtccgaaga aaagcgcggc ctaaagcgcg agtctggtga cttggcaccc 17040 accgtgcagc tgatggtacc caagcgccag cgactggaag atgtcttgga aaaaatgacc 17100 gtggaacctg ggctggagcc cgaggtccgc gtgcggccaa tcaagcaggt ggcgccggga 17160 ctgggcgtgc agaccgtgga cgttcagata cccactacca gtagcaccag tattgccacc 17220 gccacagagg gcatggagac acaaacgtcc ccggttgcct cagcggtggc ggatgccgcg 17280 gtgcaggcgg tcgctgcggc cgcgtccaag acctctacgg aggtgcaaac ggacccgtgg 17340 atgtttcgcg tttcagcccc ccggcgcccg cgcggttcga ggaagtacgg cgccgccagc 17400 gcgctactgc ccgaatatgc cctacatcct tccattgcgc ctacccccgg ctatcgtggc 17460 tacacctacc gccccagaag acgagcaact acccgacgcc gaaccaccac tggaacccgc 17520 cgccgccgtc gccgtcgcca gcccgtgctg gccccgattt ccgtgcgcag ggtggctcgc 17580 gaaggaggca ggaccctggt gctgccaaca gcgcgctacc accccagcat cgtttaaaag 17640 ccggtctttg tggttcttgc agatatggcc ctcacctgcc gcctccgttt cccggtgccg 17700 ggattccgag gaagaatgca ccgtaggagg ggcatggccg gccacggcct gacgggcggc 17760 atgcgtcgtg cgcaccaccg gcggcggcgc gcgtcgcacc gtcgcatgcg cggcggtatc 17820 ctgcccctcc ttattccact gatcgccgcg gcgattggcg ccgtgcccgg aattgcatcc 17880 gtggccttgc aggcgcagag acactgatta aaaacaagtt gcatgtggaa aaatcaaaat 17940 aaaaagtctg gactctcacg ctcgcttggt cctgtaacta ttttgtagaa tggaagacat 18000 caactttgcg tctctggccc cgcgacacgg ctcgcgcccg ttcatgggaa actggcaaga 18060 tatcggcacc agcaatatga gcggtggcgc cttcagctgg ggctcgctgt ggagcggcat 18120 taaaaatttc ggttccaccg ttaagaacta tggcagcaag gcctggaaca gcagcacagg 18180 ccagatgctg agggataagt tgaaagagca aaatttccaa caaaaggtgg tagatggcct 18240 ggcctctggc attagcgggg tggtggacct ggccaaccag gcagtgcaaa ataagattaa 18300 cagtaagctt gatccccgcc ctcccgtaga ggagcctcca ccggccgtgg agacagtgtc 18360 tccagagggg cgtggcgaaa agcgtccgcg ccccgacagg gaagaaactc tggtgacgca 18420 aatagacgag cctccctcgt acgaggaggc actaaagcaa ggcctgccca ccacccgtcc 18480 catcgcgccc atggctaccg gagtgctggg ccagcacaca cccgtaacgc tggacctgcc 18540 tccccccgcc gacacccagc agaaacctgt gctgccaggc ccgaccgccg ttgttgtaac 18600 ccgtcctagc cgcgcgtccc tgcgccgcgc cgccagcggt ccgcgatcgt tgcggcccgt 18660 agccagtggc aactggcaaa gcacactgaa cagcatcgtg ggtctggggg tgcaatccct 18720 gaagcgccga cgatgcttct gaatagctaa cgtgtcgtat gtgtgtcatg tatgcgtcca 18780 tgtcgccgcc agaggagctg ctgagccgcc gcgcgcccgc tttccaagat ggctacccct 18840 tcgatgatgc cgcagtggtc ttacatgcac atctcgggcc aggacgcctc ggagtacctg 18900 agccccgggc tggtgcagtt tgcccgcgcc accgagacgt acttcagcct gaataacaag 18960 tttagaaacc ccacggtggc gcctacgcac gacgtgacca cagaccggtc ccagcgtttg 19020 acgctgcggt tcatccctgt ggaccgtgag gatactgcgt actcgtacaa ggcgcggttc 19080 accctagctg tgggtgataa ccgtgtgctg gacatggctt ccacgtactt tgacatccgc 19140 ggcgtgctgg acaggggccc tacttttaag ccctactctg gcactgccta caacgccctg 19200 gctcccaagg gtgccccaaa tccttgcgaa tgggatgaag ctgctactgc tcttgaaata 19260 aacctagaag aagaggacga tgacaacgaa gacgaagtag acgagcaagc tgagcagcaa 19320 aaaactcacg tatttgggca ggcgccttat tctggtataa atattacaaa ggagggtatt 19380 caaataggtg tcgaaggtca aacacctaaa tatgccgata aaacatttca acctgaacct 19440 caaataggag aatctcagtg gtacgaaact gaaattaatc atgcagctgg gagagtcctt 19500 aaaaagacta ccccaatgaa accatgttac ggttcatatg caaaacccac aaatgaaaat 19560 ggagggcaag gcattcttgt aaagcaacaa aatggaaagc tagaaagtca agtggaaatg 19620 caatttttct caactactga ggcgaccgca ggcaatggtg ataacttgac tcctaaagtg 19680 gtattgtaca gtgaagatgt agatatagaa accccagaca ctcatatttc ttacatgccc 19740 actattaagg aaggtaactc acgagaacta atgggccaac aatctatgcc caacaggcct 19800 aattacattg cttttaggga caattttatt ggtctaatgt attacaacag cacgggtaat 19860 atgggtgttc tggcgggcca agcatcgcag ttgaatgctg ttgtagattt gcaagacaga 19920 aacacagagc tttcatacca gcttttgctt gattccattg gtgatagaac caggtacttt 19980 tctatgtgga atcaggctgt tgacagctat gatccagatg ttagaattat tgaaaatcat 20040 ggaactgaag atgaacttcc aaattactgc tttccactgg gaggtgtgat taatacagag 20100 actcttacca aggtaaaacc taaaacaggt caggaaaatg gatgggaaaa agatgctaca 20160 gaattttcag ataaaaatca aataagagtt ggaaataatt ttgccatgga aatcaatcta 20220 aatgccaacc tgtggagaaa tttcctgtac tccaacatag cgctgtattt gcccgacaag 20280 ctaaagtaca gtccttccaa cgtaaaaatt tctgataacc caaacaccta cgactacatg 20340 aacaagcgag tggtggctcc cgggttagtg gactgctaca ttaaccttgg agcacgctgg 20400 tcccttgact atatggacaa cgtcaaccca tttaaccacc accgcaatgc tggcctgcgc 20460 taccgctcaa tgttgctggg caatggtcgc tatgtgccct tccacatcca ggtgcctcag 20520 aagttctttg ccattaaaaa cctccttctc ctgccgggct catacaccta cgagtggaac 20580 ttcaggaagg atgttaacat ggttctgcag agctccctag gaaatgacct aagggttgac 20640 ggagccagca ttaagtttga tagcatttgc ctttacgcca ccttcttccc catggcccac 20700 aacaccgcct ccacgcttga ggccatgctt agaaacgaca ccaacgacca gtcctttaac 20760 gactatctct ccgccgccaa catgctctac cctatacccg ccaacgctac caacgtgccc 20820 atatccatcc cctcccgcaa ctgggcggct ttccgcggct gggccttcac gcgccttaag 20880 actaaggaaa ccccatcact gggctcgggc tacgaccctt attacaccta ctctggctct 20940 ataccctacc tagatggaac cttttacctc aaccacacct ttaagaaggt ggccattacc 21000 tttgactctt ctgtcagctg gcctggcaat gaccgcctgc ttacccccaa cgagtttgaa 21060 attaagcgct cagttgacgg ggagggttac aacgttgccc agtgtaacat gaccaaagac 21120 tggttcctgg tacaaatgct agctaactac aacattggct accagggctt ctatatccca 21180 gagagctaca aggaccgcat gtactccttc tttagaaact tccagcccat gagccgtcag 21240 gtggtggatg atactaaata caaggactac caacaggtgg gcatcctaca ccaacacaac 21300 aactctggat ttgttggcta ccttgccccc accatgcgcg aaggacaggc ctaccctgct 21360 aacttcccct atccgcttat aggcaagacc gcagttgaca gcattaccca gaaaaagttt 21420 ctttgcgatc gcaccctttg gcgcatccca ttctccagta actttatgtc catgggcgca 21480 ctcacagacc tgggccaaaa ccttctctac gccaactccg cccacgcgct agacatgact 21540 tttgaggtgg atcccatgga cgagcccacc cttctttatg ttttgtttga agtctttgac 21600 gtggtccgtg tgcaccggcc gcaccgcggc gtcatcgaaa ccgtgtacct gcgcacgccc 21660 ttctcggccg gcaacgccac aacataaaga agcaagcaac atcaacaaca gctgccgcca 21720 tgggctccag tgagcaggaa ctgaaagcca ttgtcaaaga tcttggttgt gggccatatt 21780 ttttgggcac ctatgacaag cgctttccag gctttgtttc tccacacaag ctcgcctgcg 21840 ccatagtcaa tacggccggt cgcgagactg ggggcgtaca ctggatggcc tttgcctgga 21900 acccgcactc aaaaacatgc tacctctttg agccctttgg cttttctgac cagcgactca 21960 agcaggttta ccagtttgag tacgagtcac tcctgcgccg tagcgccatt gcttcttccc 22020 ccgaccgctg tataacgctg gaaaagtcca cccaaagcgt acaggggccc aactcggccg 22080 cctgtggact attctgctgc atgtttctcc acgcctttgc caactggccc caaactccca 22140 tggatcacaa ccccaccatg aaccttatta ccggggtacc caactccatg ctcaacagtc 22200 cccaggtaca gcccaccctg cgtcgcaacc aggaacagct ctacagcttc ctggagcgcc 22260 actcgcccta cttccgcagc cacagtgcgc agattaggag cgccacttct ttttgtcact 22320 tgaaaaacat gtaaaaataa tgtactagag acactttcaa taaaggcaaa tgcttttatt 22380 tgtacactct cgggtgatta tttaccccca cccttgccgt ctgcgccgtt taaaaatcaa 22440 aggggttctg ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga tactggtgtt 22500 tagtgctcca cttaaactca ggcacaacca tccgcggcag ctcggtgaag ttttcactcc 22560 acaggctgcg caccatcacc aacgcgttta gcaggtcggg cgccgatatc ttgaagtcgc 22620 agttggggcc tccgccctgc gcgcgcgagt tgcgatacac agggttgcag cactggaaca 22680 ctatcagcgc cgggtggtgc acgctggcca gcacgctctt gtcggagatc agatccgcgt 22740 ccaggtcctc cgcgttgctc agggcgaacg gagtcaactt tggtagctgc cttcccaaaa 22800 agggcgcgtg cccaggcttt gagttgcact cgcaccgtag tggcatcaaa aggtgaccgt 22860 gcccggtctg ggcgttagga tacagcgcct gcataaaagc cttgatctgc ttaaaagcca 22920 cctgagcctt tgcgccttca gagaagaaca tgccgcaaga cttgccggaa aactgattgg 22980 ccggacaggc cgcgtcgtgc acgcagcacc ttgcgtcggt gttggagatc tgcaccacat 23040 ttcggcccca ccggttcttc acgatcttgg ccttgctaga ctgctccttc agcgcgcgct 23100 gcccgttttc gctcgtcaca tccatttcaa tcacgtgctc cttatttatc ataatgcttc 23160 cgtgtagaca cttaagctcg ccttcgatct cagcgcagcg gtgcagccac aacgcgcagc 23220 ccgtgggctc gtgatgcttg taggtcacct ctgcaaacga ctgcaggtac gcctgcagga 23280 atcgccccat catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc aacccgcggt 23340 gctcctcgtt cagccaggtc ttgcatacgg ccgccagagc ttccacttgg tcaggcagta 23400 gtttgaagtt cgcctttaga tcgttatcca cgtggtactt gtccatcagc gcgcgcgcag 23460 cctccatgcc cttctcccac gcagacacga tcggcacact cagcgggttc atcaccgtaa 23520 tttcactttc cgcttcgctg ggctcttcct cttcctcttg cgtccgcata ccacgcgcca 23580 ctgggtcgtc ttcattcagc cgccgcactg tgcgcttacc tcctttgcca tgcttgatta 23640 gcaccggtgg gttgctgaaa cccaccattt gtagcgccac atcttctctt tcttcctcgc 23700 tgtccacgat tacctctggt gatggcgggc gctcgggctt gggagaaggg cgcttctttt 23760 tcttcttggg cgcaatggcc aaatccgccg ccgaggtcga tggccgcggg ctgggtgtgc 23820 gcggcaccag cgcgtcttgt gatgagtctt cctcgtcctc ggactcgata cgccgcctca 23880 tccgcttttt tgggggcgcc cggggaggcg gcggcgacgg ggacggggac gacacgtcct 23940 ccatggttgg gggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt tcgcgctgct 24000 cctcttcccg actggccatt tccttctcct ataggcagaa aaagatcatg gagtcagtcg 24060 agaagaagga cagcctaacc gccccctctg agttcgccac caccgcctcc accgatgccg 24120 ccaacgcgcc taccaccttc cccgtcgagg cacccccgct tgaggaggag gaagtgatta 24180 tcgagcagga cccaggtttt gtaagcgaag acgacgagga ccgctcagta ccaacagagg 24240 ataaaaagca agaccaggac aacgcagagg caaacgagga acaagtcggg cggggggacg 24300 aaaggcatgg cgactaccta gatgtgggag acgacgtgct gttgaagcat ctgcagcgcc 24360 agtgcgccat tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc gccatagcgg 24420 atgtcagcct tgcctacgaa cgccacctat tctcaccgcg cgtacccccc aaacgccaag 24480 aaaacggcac atgcgagccc aacccgcgcc tcaacttcta ccccgtattt gccgtgccag 24540 aggtgcttgc cacctatcac atctttttcc aaaactgcaa gataccccta tcctgccgtg 24600 ccaaccgcag ccgagcggac aagcagctgg ccttgcggca gggcgctgtc atacctgata 24660 tcgcctcgct caacgaagtg ccaaaaatct ttgagggtct tggacgcgac gagaagcgcg 24720 cggcaaacgc tctgcaacag gaaaacagcg aaaatgaaag tcactctgga gtgttggtgg 24780 aactcgaggg tgacaacgcg cgcctagccg tactaaaacg cagcatcgag gtcacccact 24840 ttgcctaccc ggcacttaac ctacccccca aggtcatgag cacagtcatg agtgagctga 24900 tcgtgcgccg tgcgcagccc ctggagaggg atgcaaattt gcaagaacaa acagaggagg 24960 gcctacccgc agttggcgac gagcagctag cgcgctggct tcaaacgcgc gagcctgccg 25020 acttggagga gcgacgcaaa ctaatgatgg ccgcagtgct cgttaccgtg gagcttgagt 25080 gcatgcagcg gttctttgct gacccggaga tgcagcgcaa gctagaggaa acattgcact 25140 acacctttcg acagggctac gtacgccagg cctgcaagat ctccaacgtg gagctctgca 25200 acctggtctc ctaccttgga attttgcacg aaaaccgcct tgggcaaaac gtgcttcatt 25260 ccacgctcaa gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac ttatttctat 25320 gctacacctg gcagacggcc atgggcgttt ggcagcagtg cttggaggag tgcaacctca 25380 aggagctgca gaaactgcta aagcaaaact tgaaggacct atggacggcc ttcaacgagc 25440 gctccgtggc cgcgcacctg gcggacatca ttttccccga acgcctgctt aaaaccctgc 25500 aacagggtct gccagacttc accagtcaaa gcatgttgca gaactttagg aactttatcc 25560 tagagcgctc aggaatcttg cccgccacct gctgtgcact tcctagcgac tttgtgccca 25620 ttaagtaccg cgaatgccct ccgccgcttt ggggccactg ctaccttctg cagctagcca 25680 actaccttgc ctaccactct gacataatgg aagacgtgag cggtgacggt ctactggagt 25740 gtcactgtcg ctgcaaccta tgcaccccgc accgctccct ggtttgcaat tcgcagctgc 25800 ttaacgaaag tcaaattatc ggtacctttg agctgcaggg tccctcgcct gacgaaaagt 25860 ccgcggctcc ggggttgaaa ctcactccgg ggctgtggac gtcggcttac cttcgcaaat 25920 ttgtacctga ggactaccac gcccacgaga ttaggttcta cgaagaccaa tcccgcccgc 25980 caaatgcgga gcttaccgcc tgcgtcatta cccagggcca cattcttggc caattgcaag 26040 ccatcaacaa agcccgccaa gagtttctgc tacgaaaggg acggggggtt tacttggacc 26100 cccagtccgg cgaggagctc aacccaatcc ccccgccgcc gcagccctat cagcagcagc 26160 cgcgggccct tgcttcccag gatggcaccc aaaaagaagc tgcagctgcc gccgccaccc 26220 acggacgagg aggaatactg ggacagtcag gcagaggagg ttttggacga ggaggaggag 26280 gacatgatgg aagactggga gagcctagac gaggaagctt ccgaggtcga agaggtgtca 26340 gacgaaacac cgtcaccctc ggtcgcattc ccctcgccgg cgccccagaa atcggcaacc 26400 ggttccagca tggctacaac ctccgctcct caggcgccgc cggcactgcc cgttcgccga 26460 cccaaccgta gatgggacac cactggaacc agggccggta agtccaagca gccgccgccg 26520 ttagcccaag agcaacaaca gcgccaaggc taccgctcat ggcgcgggca caagaacgcc 26580 atagttgctt gcttgcaaga ctgtgggggc aacatctcct tcgcccgccg ctttcttctc 26640 taccatcacg gcgtggcctt cccccgtaac atcctgcatt actaccgtca tctctacagc 26700 ccatactgca ccggcggcag cggcagcggc agcaacagca gcggccacac agaagcaaag 26760 gcgaccggat agcaagactc tgacaaagcc caagaaatcc acagcggcgg cagcagcagg 26820 aggaggagcg ctgcgtctgg cgcccaacga acccgtatcg acccgcgagc ttagaaacag 26880 gatttttccc actctgtatg ctatatttca acagagcagg ggccaagaac aagagctgaa 26940 aataaaaaac aggtctctgc gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga 27000 tcagcttcgg cgcacgctgg aagacgcgga ggctctcttc agtaaatact gcgcgctgac 27060 tcttaaggac tagtttcgcg ccctttctca aatttaagcg cgaaaactac gtcatctcca 27120 gcggccacac ccggcgccag cacctgtcgt cagcgccatt tatgagcaag gaaattccca 27180 cgccctacat gtggagttac cagccacaaa tgggacttgc ggctggagct gcccaagact 27240 actcaacccg aataaactac atgagcgcgg gaccccacat gatatcccgg gtcaacggaa 27300 tacgcgccca ccgaaaccga attctcctgg aacaggcggc tattaccacc acacctcgta 27360 ataaccttaa tccccgtagt tggcccgctg ccctggtgta ccaggaaagt cccgctccca 27420 ccactgtggt acttcccaga gacgcccagg ccgaagttca gatgactaac tcaggggcgc 27480 agcttgcggg cggctttcgt cacagggtgc ggtcgcccgg gcagggtata actcacctga 27540 caatcagagg gcgaggtatt cagctcaacg acgagtcggt gagctcctcg cttggtctcc 27600 gtccggacgg gacatttcag atcggcggcg ccggccgctc ttcattcacg cctcgtcagg 27660 caatcctaac tctgcagacc tcgtcctctg agccgcgctc tggaggcatt ggaactctgc 27720 aatttattga ggagtttgtg ccatcggtct actttaaccc cttctcggga cctcccggcc 27780 actatccgga tcaatttatt cctaactttg acgcggtaaa ggactcggcg gacggctacg 27840 actgaatgtt aagtggagag gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc 27900 gccacaagtg ctttgcccgc gactccggtg agttttgcta ctttgaattg cccgaggatc 27960 atatcgaggg cccggcgcac ggcgtccggc ttaccgccca gggagagctt gcccgtagcc 28020 tgattcggga gtttacccag cgccccctgc tagttgagcg ggacagggga ccctgtgttc 28080 tcactgtgat ttgcaactgt cctaaccctg gattacatca agatctttgt tgccatctct 28140 gtgctgagta taataaatac agaaattaaa atatactggg gctcctatcg ccatcctgta 28200 aacgccaccg tcttcacccg cccaagcaaa ccaaggcgaa ccttacctgg tacttttaac 28260 atctctccct ctgtgattta caacagtttc aacccagacg gagtgagtct acgagagaac 28320 ctctccgagc tcagctactc catcagaaaa aacaccaccc tccttacctg ccgggaacgt 28380 acgagtgcgt caccggccgc tgcaccacac ctaccgcctg accgtaaacc agactttttc 28440 cggacagacc tcaataactc tgtttaccag aacaggaggt gagcttagaa aacccttagg 28500 gtattaggcc aaaggcgcag ctactgtggg gtttatgaac aattcaagca actctacggg 28560 ctattctaat tcaggtttct ctagaatcgg ggttggggtt attctctgtc ttgtgattct 28620 ctttattctt atactaacgc ttctctgcct aaggctcgcc gcctgctgtg tgcacatttg 28680 catttattgt cagcttttta aacgctgggg tcgccaccca agatgattag gtacataatc 28740 ctaggtttac tcacccttgc gtcagcccac ggtaccaccc aaaaggtgga ttttaaggag 28800 ccagcctgta atgttacatt cgcagctgaa gctaatgagt gcaccactct tataaaatgc 28860 accacagaac atgaaaagct gcttattcgc cacaaaaaca aaattggcaa gtatgctgtt 28920 tatgctattt ggcagccagg tgacactaca gagtataatg ttacagtttt ccagggtaaa 28980 agtcataaaa cttttatgta tacttttcca ttttatgaaa tgtgcgacat taccatgtac 29040 atgagcaaac agtataagtt gtggccccca caaaattgtg tggaaaacac tggcactttc 29100 tgctgcactg ctatgctaat tacagtgctc gctttggtct gtaccctact ctatattaaa 29160 tacaaaagca gacgcagctt tattgaggaa aagaaaatgc cttaatttac taagttacaa 29220 agctaatgtc accactaact gctttactcg ctgcttgcaa aacaaattca aaaagttagc 29280 attataatta gaataggatt taaacccccc ggtcatttcc tgctcaatac cattcccctg 29340 aacaattgac tctatgtggg atatgctcca gcgctacaac cttgaagtca ggcttcctgg 29400 atgtcagcat ctgactttgg ccagcacctg tcccgcggat ttgttccagt ccaactacag 29460 cgacccaccc taacagagat gaccaacaca accaacgcgg ccgccgctac cggacttaca 29520 tctaccacaa atacacccca agtttctgcc tttgtcaata actgggataa cttgggcatg 29580 tggtggttct ccatagcgct tatgtttgta tgccttatta ttatgtggct catctgctgc 29640 ctaaagcgca aacgcgcccg accacccatc tatagtccca tcattgtgct acacccaaac 29700 aatgatggaa tccatagatt ggacggactg aaacacatgt tcttttctct tacagtatga 29760 ttaaatgaga catgattcct cgagttttta tattactgac ccttgttgcg cttttttgtg 29820 cgtgctccac attggctgcg gtttctcaca tcgaagtaga ctgcattcca gccttcacag 29880 tctatttgct ttacggattt gtcaccctca cgctcatctg cagcctcatc actgtggtca 29940 tcgcctttat ccagtgcatt gactgggtct gtgtgcgctt tgcatatctc agacaccatc 30000 cccagtacag ggacaggact atagctgagc ttcttagaat tctttaatta tgaaatttac 30060 tgtgactttt ctgctgatta tttgcaccct atctgcgttt tgttccccga cctccaagcc 30120 tcaaagacat atatcatgca gattcactcg tatatggaat attccaagtt gctacaatga 30180 aaaaagcgat ctttccgaag cctggttata tgcaatcatc tctgttatgg tgttctgcag 30240 taccatctta gccctagcta tatatcccta ccttgacatt ggctggaacg caatagatgc 30300 catgaaccac ccaactttcc ccgcgcccgc tatgcttcca ctgcaacaag ttgttgccgg 30360 cggctttgtc ccagccaatc agcctcgccc accttctccc acccccactg aaatcagcta 30420 ctttaatcta acaggaggag atgactgaca ccctagatct agaaatggac ggaattatta 30480 cagagcagcg cctgctagaa agacgcaggg cagcggccga gcaacagcgc atgaatcaag 30540 agctccaaga catggttaac ttgcaccagt gcaaaagggg tatcttttgt ctggtaaagc 30600 aggccaaagt cacctacgac agtaatacca ccggacaccg ccttagctac aagttgccaa 30660 ccaagcgtca gaaattggtg gtcatggtgg gagaaaagcc cattaccata actcagcact 30720 cggtagaaac cgaaggctgc attcactcac cttgtcaagg acctgaggat ctctgcaccc 30780 ttattaagac cctgtgcggt ctcaaagatc ttattccctt taactaataa aaaaaaataa 30840 taaagcatca cttacttaaa atcagttagc aaatttctgt ccagtttatt cagcagcacc 30900 tccttgccct cctcccagct ctggtattgc agcttcctcc tggctgcaaa ctttctccac 30960 aatctaaatg gaatgtcagt ttcctcctgt tcctgtccat ccgcacccac tatcttcatg 31020 ttgttgcaga tgaagcgcgc aagaccgtct gaagatacct tcaaccccgt gtatccatat 31080 gacacggaaa ccggtcctcc aactgtgcct tttcttactc ctccctttgt atcccccaat 31140 gggtttcaag agagtccccc tggggtactc tctttgcgcc tatccgaacc tctagttacc 31200 tccaatggca tgcttgcgct caaaatgggc aacggcctct ctctggacga ggccggcaac 31260 cttacctccc aaaatgtaac cactgtgagc ccacctctca aaaaaaccaa gtcaaacata 31320 aacctggaaa tatctgcacc cctcacagtt acctcagaag ccctaactgt ggctgccgcc 31380 gcacctctaa tggtcgcggg caacacactc accatgcaat cacaggcccc gctaaccgtg 31440 cacgactcca aacttagcat tgccacccaa ggacccctca cagtgtcaga aggaaagcta 31500 gccctgcaaa catcaggccc cctcaccacc accgatagca gtacccttac tatcactgcc 31560 tcaccccctc taactactgc cactggtagc ttgggcattg acttgaaaga gcccatttat 31620 acacaaaatg gaaaactagg actaaagtac ggggctcctt tgcatgtaac agacgaccta 31680 aacactttga ccgtagcaac tggtccaggt gtgactatta ataatacttc cttgcaaact 31740 aaagttactg gagccttggg ttttgattca caaggcaata tgcaacttaa tgtagcagga 31800 ggactaagga ttgattctca aaacagacgc cttatacttg atgttagtta tccgtttgat 31860 gctcaaaacc aactaaatct aagactagga cagggccctc tttttataaa ctcagcccac 31920 aacttggata ttaactacaa caaaggcctt tacttgttta cagcttcaaa caattccaaa 31980 aagcttgagg ttaacctaag cactgccaag gggttgatgt ttgacgctac agccatagcc 32040 attaatgcag gagatgggct tgaatttggt tcacctaatg caccaaacac aaatcccctc 32100 aaaacaaaaa ttggccatgg cctagaattt gattcaaaca aggctatggt tcctaaacta 32160 ggaactggcc ttagttttga cagcacaggt gccattacag taggaaacaa aaataatgat 32220 aagctaactc tttggacaac accagacaca tctccaaact gcacaattgc tcaagataag 32280 gactctaaac tcactttggt acttacaaag tgtggaagtc aaatattagc taatgtgtct 32340 ttgattgtgg tcgcaggaaa gtaccacatc ataaataata agacaaatcc aaaaataaaa 32400 agttttacta ttaaactgct atttaataag aacggagtgc ttttagacaa ctcaaatctt 32460 ggaaaagctt attggaactt tagaagtgga aattccaatg tttcgacagc ttatgaaaaa 32520 gcaattggtt ttatgcctaa tttggtagcg tatccaaaac ccagtaattc taaaaaatat 32580 gcaagagaca tagtttatgg aactatatat cttggtggaa aacctgatca gccagcagtc 32640 attaaaacta cctttaacca agaaactgga tgtgaatact ctatcacatt taactttagt 32700 tggtccaaaa cctatgaaaa tgttgaattt gaaaccacct cttttacctt ctcctatatt 32760 gcccaagaat aataaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca 32820 gaaaatttca agtcattttt cattcagtag tatagcccca ccaccacata gcttatacag 32880 atcaccgtac cttaatcaaa cctacatggg ggtagagtca taatcgtgca tcaggatagg 32940 gcggtggtgc tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga 33000 atacaacatg gcagtggtct cctcagcgat gattcgcacc gcccgcagca taaggcgcct 33060 tgtcctccgg gcacagcagc gcaccctgat ctcacttaaa tcagcacagt aactgcagca 33120 cagcaccaca atattgttca aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc 33180 ggggaccaca gaacccacgt ggccatcata ccacaagcgc aggtagatta agtggcgacc 33240 cctcataaac acgctggaca taaacattac ctcttttggc atgttgtaat tcaccacctc 33300 ccggtaccat ataaacctct gattaaacat ggcgccatcc accaccatcc taaaccagct 33360 ggccaaaacc tgcccgccgg ctatacactg cagggaaccg ggactggaac aatgacagtg 33420 gagagcccag gactcgtaac catggatcat catgctcgtc atgatatcaa tgttggcaca 33480 acacaggcac acgtgcatac acttcctcag gattacaagc tcctcccgcg ttagaaccat 33540 atcccaggga acaacccatt cctgaatcag cgtaaatccc acactgcagg gaagacctcg 33600 cacgtaactc acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc 33660 cagtatggta gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac tgtacggagt 33720 gcgccgagac aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt 33780 agtcatattt cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg cgtctccggt 33840 ctcgccgctt agatcgctct gtgtagtagt tgtagtatat ccactctctc aaagcatcca 33900 ggcgccccct ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc ctgataacat 33960 ccaccaccgc agaataagcc acacccagcc aacctacaca ttcgttctgc gagtcacaca 34020 cgggaggagc gggaagagct ggaagaacca tgtttttttt tttattccaa aagattatcc 34080 aaaacctcaa aatgaagatc tattaagtga acgcgctccc ctccggtggc gtggtcaaac 34140 tctacagcca aagaacagat aatggcattt gtaagatgtt gcacaatggc ttccaaaagg 34200 caaacggccc tcacgtccaa gtggacgtaa aggctaaacc cttcagggtg aatctcctct 34260 ataaacattc cagcaccttc aaccatgccc aaataattct catctcgcca ccttctcaat 34320 atatctctaa gcaaatcccg aatattaagt ccggccattg taaaaatctg ctccagagcg 34380 ccctccacct tcagcctcaa gcagcgaatc atgattgcaa aaattcaggt tcctcacaga 34440 cctgtataag attcaaaagc ggaacattaa caaaaatacc gcgatcccgt aggtcccttc 34500 gcagggccag ctgaacataa tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc 34560 caggaaccat gacaaaagaa cccacactga ttatgacacg catactcgga gctatgctaa 34620 ccagcgtagc cccgatgtaa gcttgttgca tgggcggcga tataaaatgc aaggtgctgc 34680 tcaaaaaatc aggcaaagcc tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca 34740 gataaaggca ggtaagctcc ggaaccacca cagaaaaaga caccattttt ctctcaaaca 34800 tgtctgcggg tttctgcata aacacaaaat aaaataacaa aaaaacattt aaacattaga 34860 agcctgtctt acaacaggaa aaacaaccct tataagcata agacggacta cggccatgcc 34920 ggcgtgaccg taaaaaaact ggtcaccgtg attaaaaagc accaccgaca gctcctcggt 34980 catgtccgga gtcataatgt aagactcggt aaacacatca ggttgattca catcggtcag 35040 tgctaaaaag cgaccgaaat agcccggggg aatacatacc cgcaggcgta gagacaacat 35100 tacagccccc ataggaggta taacaaaatt aataggagag aaaaacacat aaacacctga 35160 aaaaccctcc tgcctaggca aaatagcacc ctcccgctcc agaacaacat acagcgcttc 35220 cacagcggca gccataacag tcagccttac cagtaaaaaa gaaaacctat taaaaaaaca 35280 ccactcgaca cggcaccagc tcaatcagtc acagtgtaaa aaagggccaa gtgcagagcg 35340 agtatatata ggactaaaaa atgacgtaac ggttaaagtc cacaaaaaac acccagaaaa 35400 ccgcacgcga acctacgccc agaaacgaaa gccaaaaaac ccacaacttc ctcaaatcgt 35460 cacttccgtt ttcccacgtt acgtcacttc ccattttaag aaaactacaa ttcccaacac 35520 atacaagtta ctccgcccta aaacctacgt cacccgcccc gttcccacgc cccgcgccac 35580 gtcacaaact ccaccccctc attatcatat tggcttcaat ccaaaataag gtatattatt 35640 gatgatg 35647 <210> 85 <211> 34331 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO510) <400> 85 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccttatgag 3600 tggaaacgct tcttttaagg ggggagtctt cagcccttat ctgacagggc gtctcccatc 3660 ctgggcagga gttcgtcaga atgttatggg atctactgtg gatggaagac ccgtccaacc 3720 cgccaattct tcaacgctga cctatgctac tttaagttct tcacctttgg acgcagctgc 3780 agccgccgcc gccgcctctg ttgccgctaa cactgtgctt ggaatgggtt actatggaag 3840 tatcgtggct aattccactt cctctaataa cccttctacc ctgactcagg acaagttact 3900 tgtccttttg gcccagctgg aggctttgac ccaacgtctg ggtgaacttt atcagcaggt 3960 ggccgagttg cgagtacaaa ctgagtctgc tgtcggcacg gcaaagtcta aataaaacat 4020 aaataaaaaa ccagactctg tttggatttg gatcaagcaa aatcaagtgt ttttatttca 4080 tttttcgcgc acggtatgcc ctagaccacc gatctcgatc attgagaaca cggtggattt 4140 tttccagaat cctatagagg tgggattgaa tgtttagata catgggcatt aggccatctt 4200 tggggtggag atagctccat tgaagggatt catgctccgg ggtagtgttg taaatcaccc 4260 agtcataaca aggtcgcagt gcatggtgtt gcacaatatc ttttagaagt aggctgattg 4320 ccacagataa gcccttggtg taggtgttta caaaccggtt gagctgggag gggtgcattc 4380 ggggtgaaat tatgtgcatt ttggattgga tttttaagtt ggcaatattg ccgccaagat 4440 ctcgtcttgg gttcatgtta tgaaggacca ccaagacggt gtatccggta catttaggaa 4500 atttatcgtg tagcttggat ggaaaagcgt ggaaaaattt ggagacaccc ttgtgtcctc 4560 cgagattttc catgcactca tccatgataa tagcaatggg gccgtgggca gcagcgcggg 4620 caaacacgtt ccgtgggtct gacacatcat agttatgttc ctgagttaaa tcatcataag 4680 ccattttaat gaatttgggg cggagagtac ccgattgggg tatgaatgtt ccttcgggcc 4740 ccggagcata gttcccctca cagatttgca tttcccaagc tttcagttcc gatggtggaa 4800 tcatgtccac ctggggggct atgaagaaca ccgtttctgg ggcgggggtg attagttggg 4860 atgatagcaa gtttctgagc aattgagatt tgccacatcc ggtggggcca taaatgattc 4920 cgattacagg ttgcaggtgg tagtttaggg aacggcaact gccgtcttct cgaagcaagg 4980 gggccacctc gttcatcatt tcccttacat gcatattttc ccgcaccaaa tccattagga 5040 ggcgctctcc tcctagtgat agaagttctt gtagtgagga aaagtttttc agcggtttta 5100 gaccgtcagc catgggcatt ttggagagag tttgctgcaa aagttctagt ctgttccaca 5160 gttcagtgat gtgttctatg gcatctcgat ccagcagacc tcctcgtttc gcgggtttgg 5220 acggctcctg gagtagggta tgagacgatg ggcgtccagc gctgccaggg ttcggtcctt 5280 ccagggtctc agtgttcgag tcagggttgt ttccgtcaca gtgaaggggt gtgcgcctgc 5340 ttgggcgctt gccagggtgc gcttcagact cattctgctg gtggagaact tctgtcgctt 5400 ggcgccctgt atgtcggcca agtagcagtt taccatgagt tcgtagttga gcgcctcggc 5460 tgcgtggcct ttggcgcgga gcttaccttt ggaagttttc ttgcataccg ggcagtatag 5520 gcatttcagc gcatacagct tgggcgcaag gaaaatggat tctggggagt atgcatctgc 5580 gccgcaggag gcgcaaacag tttcacattc caccagccag gttaaatccg gttcattggg 5640 gtcaaaaaca agttttccgc catatttttt gatgcgtttc ttacctttgg tctccatgag 5700 ttcgtgtcct cgttgagtga caaacaggct gtccgtatcc ccgtagactg attttacagg 5760 cctcttctcc agtggagtgc ctcggtcttc ttcgtacagg aactctgacc actctgatac 5820 aaaggcgcgc gtccaggcca gcacaaagga ggctatgtgg gaggggtagc gatcgttgtc 5880 aaccaggggg tccacctttt ccaaagtatg caaacacatg tcaccctctt caacatccag 5940 gaatgtgatt ggcttgtagg tgtatttcac gtgacctggg gtccccgctg ggggggtata 6000 aaagggggcg gttctttgct cttcctcact gtcttccgga tcgctgtcca ggaacgtcag 6060 ctgttggggt aggtattccc tctcgaaggc gggcatgacc tctgcactca ggttgtcagt 6120 ttctaagaac gaggaggatt tgatattgac agtgccggtt gagatgcctt tcatgaggtt 6180 ttcgtccatt tggtcagaaa acacaatttt tttattgtca agtttggtgg caaatgatcc 6240 atacagggcg ttggataaaa gtttggcaat ggatcgcatg gtttggttct tttccttgtc 6300 cgcgcgctct ttggcagcga tgttgagttg gacatactcg cgtgctaggc acttccattc 6360 ggggaagata gttgtcaatt catctggcac gattctcact tgccaccctc gattatgcaa 6420 ggtaattaaa tccacactgg tggccacctc gcctcgaagg ggttcgttgg tccaacagag 6480 cctacctcct ttcctagaac agaaaggggg aagtgggtct agcataagtt catcgggagg 6540 gtctgcatcc atggtaaaga ttcccggaag taaatcctta tcaaaatagc tgatgggagt 6600 ggggtcatct aaggccattt gccattctcg agctgccagt gcacgctcat atgggttaag 6660 gggactgccc cagggcatgg gatgggtgag tgcagaggca tacatgccac agatgtcata 6720 gacgtagatg ggatcctcaa agatgcctat ataggttgga tagcatcgcc cccctctgat 6780 acttgctcgc acatagtcat atagttcatg tgatggcgct agcaaccccg gacccaagtt 6840 ggtgcgattg ggtttttctg ttctgtagac aatctggcga aagatggcgt gagaattgga 6900 agagatggtg ggtctttgaa aaatgttgaa atgggcatga ggtagaccta cagagtctct 6960 gacaaagtgg gcataagatt cttgaagctt ggttaccagt tcggcggtga caagtacgtc 7020 tagggcgcag tagtcaagtg tttcttgaat gatgtcataa cctggttggt ttttcttttc 7080 ccacagttcg cggttgagaa ggtattcttc gcgatccttc cagtactctt ctagcggaaa 7140 cccgtctttg tctgcacggt aagatcctag catgtagaac tgattaactg ccttgtaagg 7200 gcagcagccc ttctctacgg gtagagagta tgcttgagca gcttttcgca gcgaagcgtg 7260 agtaagggcg aaggtgtctc tgaccatgac tttgagaaat tggtatttga agtccatgtc 7320 gtcacaggct ccctgttccc agagttggaa gtctacccgt ttcttgtagg cggggttggg 7380 caaagcgaaa gtaacatcgt tgaagagaat cttaccggct ctgggcataa aattgcgagt 7440 gatgcggaaa ggctgtggta cttccgctcg attgttgatc acctgggcag ctaggacgat 7500 ctcgtcgaaa ccgttgatgt tgtgtcctac gatgtataat tctatgaaac gcggcgtgcc 7560 tttgacgtga ggtagcttat tgagctcatc aaaggttagg tctgtagggt cagataaggc 7620 gtagtgttcg agagcccatt cgtgcaggtg aggatttgca tgtaggaatg atgaccaaag 7680 atccaccgcc agtgctgttt gtaactggtc ccgatactga cgaaaatgct ggccaattgc 7740 cattttttct ggagtgacac agtagaaggt tctggggtct tgttgccatc gatcccactt 7800 tagtttaatg gctagatcgt gggccatgtt gacgagacgc tcttctcctg agagtttcat 7860 gaccagcatg aaaggaacta gttgtttgcc aaaggacccc atccaggtgt aagtttccac 7920 atcgtaggtc aggaagagtc tttctgtgcg aggatgagag ccgatcggga agaactggat 7980 ttcctgccac cagttggagg attggctgtt gatgtgatgg aagtagaagt ttctgcggcg 8040 cgccgagcat tcgtgtttgt gcttgtacag acggccgcag tagtcgcagc gttgcacggg 8100 ttgtatctcg tgaatgagct gtacctggct tcccttgacg agaaatttca gtgggaagcc 8160 gaggcctggc gattgtatct cgtgctcttc tatattcgct gtatcggcct gttcatcttc 8220 tgtttcggtg gtggtcatgc tgacgagccc ccgcgggagg caagtccaga cctcggcgcg 8280 ggaggggcgg agctgaagga ccagagcgcg caggctggag ctgtccagag tcctgagacg 8340 ctgcggactc aggttagtag gtagggacag aagattaact tgcatgatct tttccagggc 8400 gtgcgggagg ttcagatggt acttgatttc cacaggttcg tttgtagaga tgtcaatggc 8460 ttgcagggtt ccgtgtcctt tgggcgccac taccgtacct ttgttttttc ttttgatcgg 8520 tggtggctct cttgcttctt gcatgctcag aagcgatgac ggggacgcgc gccgggcgga 8580 agcggttgtt ccggacccgg aggcatggct ggtagtggca cgtcggcgcc gcgcacgggc 8640 aggttctggt actgcgctct gagaagactt gcgtgcgcca ccacgcgtcg attgacgtct 8700 tgtatctgac gtctctgggt gaaagctacc ggccccgtga gcttgaacct gaaagagagt 8760 tcaacagaat caatttcggt atcgttaacg gcagcttgtc tcagtatttc ttgtacgtca 8820 ccagagttgt cctggtaggc gatctccgcc atgaactgct cgatttcttc ctcctgaaga 8880 tctccgcgac ccgctctctc gacggtggcc gcgaggtcat tggagatacg gcccatgagt 8940 tgggagaatg cagtcatgcc cgcctcgttc cagacgcggc tgtaaaccac ggccccctcg 9000 gagtctcttg cgcgcatcac cacctgagcg aggttaagct ccacgtgtct ggtgaagacc 9060 gcatagttgc ataggcgctg aaaaaggtag ttgagtgtgg tggcaatgtg ttcggcgacg 9120 aagaaataca tgatccatcg tctcagcggc atttcgctga catcgcccag agcttccaag 9180 cgctccatgg cctcgtagaa gtccacggca aaattaaaaa actgggagtt tcgcgcggac 9240 acggtcaatt cctcctcgag aagacggatg agttcggcta tggtggcccg tacttcgcgt 9300 tcgaaggctc ccgggatctc ttcttcctct tctatctctt cttccactaa catctcttct 9360 tcgtcttcag gcgggggcgg agggggcaca cggcgacgtc gacggcgcac gggcaaacgg 9420 tcgatgaatc gttcaatgac ctctccgcgg cggcggcgca tggtttcagt gacggcgcgg 9480 ccgttctcgc gcggtcgcag agtaaaaaca ccgccgcgca tctccttaaa gtggtgactg 9540 ggaggttctc cgtttgggag ggagagggcg ctgattatac attttattaa ttggcccgta 9600 gggactgcgc gcagagatct gatcgtgtca agatccacgg gatctgaaaa cctttcgacg 9660 aaagcgtcta accagtcaca gtcacaaggt aggctgagta cggcttcttg tgggcggggg 9720 tggttatgtg ttcggtctgg gtcttctgtt tcttcttcat ctcgggaagg tgagacgatg 9780 ctgctggtga tgaaattaaa gtaggcagtt ctaagacggc ggatggtggc gaggagcacc 9840 aggtctttgg gtccggcttg ctggatacgc aggcgattgg ccattcccca agcattatcc 9900 tgacatctag caagatcttt gtagtagtct tgcatgagcc gttctacggg cacttcttcc 9960 tcacccgttc tgccatgcat acgtgtgagt ccaaacccgc gcattggttg taccagtgcc 10020 aagtcagcta cgactctttc ggcgaggatg gcttgctgta cttgggtgag ggtggcttga 10080 aagtcatcaa aatccacaaa gcggtggtaa gccccggtat taatggtgta agcacagttg 10140 gccatgactg accagttaac tgtctggtga ccagggcgca cgagctcggt gtatttaagg 10200 cgcgaatagg cgcgggtgtc aaagatgtaa tcgttgcagg tgcgcaccag atactggtaa 10260 cctataagaa aatgcggcgg tggttggcgg tagagaggcc atcgttctgt agctggagcg 10320 ccgggggcga ggtcttccaa cataaggcgg tgatagccgt agatgtacct ggacatccag 10380 gtgattcctg cggcggtagt agaagcccga ggaaactcgc gtacgcggtt ccaaatgttg 10440 cgtagcggca tgaagtagtt cattgtaggc acggtttgac cagtgaggcg cgcgcagtca 10500 ttgatgctct atagacacgg agaaaatgaa agcgttcagc gactcgactc cgtagcctgg 10560 aggaacgtga acgggttggg tcgcggtgta ccccggttcg agacttgtac tcgagccggc 10620 cggagccgcg gctaacgtgg tattggcact cccgtctcga cccagcctac aaaaatccag 10680 gatacggaat cgagtcgttt tgctggttgc cgaatggcag ggaagtgagt cctatttttt 10740 ttttttgccg ctcagatgca tcccgtgctg cgacagatgc gtccccaaca acagcccccc 10800 tcgcagcagc agcaaccaca aaaggctgtc cctgcaacta ctgcaactgc cgctgtgagc 10860 ggtgcgggac agcccgccta tgatctggac ttggaagagg gcgaaggact ggcacgtcta 10920 ggtgcgcctt cgcccgagcg gcatccgcga gttcaactga aaaaagattc tcgcgaggcg 10980 tatgtgcccc aacagaacct atttagagac agaagcggcg aggagccgga ggagatgcga 11040 gcttcccgct ttaacgcggg tcgtgagctg cgtcacggtt tggacagaag acgagtgttg 11100 cgggacgagg atttcgaagt tgatgaagtg acagggatca gtcctgccag ggcacacgtg 11160 gctgcagcca accttgtatc ggcttacgaa cagacagtaa aggaagagcg taatttccaa 11220 aagtctttta ataatcatgt gcgaaccctc attgcccgcg aagaagtcac ccttggtttg 11280 atgcatttgt gggatttgat ggaagctatc attcagaacc ctactagcaa acctctgacc 11340 gcacagctgt ttctggtggt gcaacacagc agagacaatg aggctttcag agaggcgctg 11400 ctcaacatca ccgaacccga ggggagatgg ttgtatgatc ttatcaacat tctacagagt 11460 atcatagtgc aggagcggag cctgggcctg gccgagaagg tggctgccat caattactcg 11520 gttttgagct tgggaaagta ttacgctcgc aagatctaca agactccata cgttcccata 11580 gacaaggagg tgaagataga tgggttctac atgcgcatga cgctgaaggt gttgaccctg 11640 agcgatgatc ttggggtgta ccgcaatgac agaatgcatc gcgcggtgag cgccagcagg 11700 aggcgcgagt taagcgacag ggaactgatg cacagtttgc aaagagctct aactggagct 11760 ggaaccgagg gtgagaatta ctttgatatg ggagctgact tgcagtggca gcctagtcgc 11820 agggctctga acgccgcgac ggcaggatgt gagcttcctt acatagaaga ggcggatgaa 11880 ggcgaggagg aagagggcga gtacttggaa gactgatggc acaacccgtg ttttttgcta 11940 gatggaacag caagcaccgg atcccgcaat gcgggcggcg ctgcagagcc agccgtccgg 12000 cattaactcc tcggacgatt ggacccaggc catgcaacgt atcatggcgt tgacgactcg 12060 caaccccgaa gcctttagac agcaacccca ggccaaccgt ctatcggcca tcatggaagc 12120 tgtagtgcct tcccgctcta atcccactca tgagaaggtc ctggccatcg tgaacgcgtt 12180 ggtggagaac aaagctattc gtccagatga ggccggactg gtatacaacg ctctcttaga 12240 acgcgtggct cgctacaaca gtagcaatgt gcaaaccaat ttggaccgta tgataacaga 12300 tgtacgcgaa gccgtgtctc agcgcgaaag gttccagcgc gatgccaacc tgggttcgct 12360 ggtggcgtta aatgctttct tgagtactca gcctgctaat gtgccgcgtg gtcaacagga 12420 ttatactaac tttttaagtg ctttgagact gatggtatca gaagtacctc agagcgaagt 12480 atatcagtcc ggtcctgatt acttctttca gactagcaga cagggcttgc agacggtaaa 12540 tctgagccaa gcttttaaaa accttaaagg tttgtgggga gtgcatgccc cggtaggaga 12600 aagagcaacc gtgtctagct tgttaactcc gaactcccgc ctattattac tgttggtagc 12660 tcctttcacc gacagcggta gcatcgaccg taattcctat ttgggttacc tactaaacct 12720 gtatcgcgaa gccatagggc aaagtcaggt ggacgagcag acctatcaag aaattaccca 12780 agtcagtcgc gctttgggac aggaagacac tggcagtttg gaagccactc tgaacttctt 12840 gcttaccaat cggtctcaaa agatccctcc tcaatatgct cttactgcgg aggaggagag 12900 gatccttaga tatgtgcagc agagcgtggg attgtttctg atgcaagagg gggcaactcc 12960 gactgcagca ctggacatga cagcgcgaaa tatggagccc agcatgtatg ccagtaaccg 13020 acctttcatt aacaaactgc tggactactt gcacagagct gccgctatga actctgatta 13080 tttcaccaat gccatcttaa acccgcactg gctgccccca cctggtttct acacgggcga 13140 atatgacatg cccgacccta atgacggatt tctgtgggac gacgtggaca gcgatgtttt 13200 ttcacctctt tctgatcatc gcacgtggaa aaaggaaggc ggcgatagaa tgcattcttc 13260 tgcatcgctg tccggggtca ttggtgctac cgcggctgag cccgagtctg caagtccttt 13320 tcctagtcta cccttttctc tacacagtgt acgtagcagc gaagtgggta gaataagtcg 13380 cccgagttta atgggcgaag aggagtacct aaacgattcc ttgctcagac cggcaagaga 13440 aaaaaatttc ccaaacaatg gaatagaaag tttggtggat aaaatgagta gatggaagac 13500 ttatgctcag gatcacagag acgagcctgg gatcatgggg actacaagta gagcgagccg 13560 tagacgccag cgccatgaca gacagagggg tcttgtgtgg gacgatgagg attcggccga 13620 tgatagcagc gtattggact tgggtgggag aggaaggggc aacccgtttg ctcatttgcg 13680 ccctcgcttg ggtggtatgt tgtaaaaaaa aataaaaaag aaaaaactca ccaaggccat 13740 ggcgacgagc gtacgttcgt tcttctttat tatctgtgtc tagtataatg aggcgagtcg 13800 tgctaggcgg agcggtggtg tatccggagg gtcctcctcc ttcgtacgag agcgtgatgc 13860 agcagcagca ggcgacggcg gtgatgcaat ccccactgga ggctcccttt gtgcctccgc 13920 gatacctggc acctacggag ggcagaaaca gcattcgtta ctcggaactg gcacctcagt 13980 acgataccac caggttgtat ctggtggaca acaagtcggc ggacattgct tctctgaact 14040 atcagaatga ccacagcaac ttcttgacca cggtggtgca aaacaatgac tttaccccta 14100 cggaagccag cacccagacc attaactttg atgaacgatc gcggtggggc ggtcagctaa 14160 aaaccatcat gcatactaac atgcccaacg tgaacgagta tatgtttagt aacaagttca 14220 aagcgcgtgt gatggtgtcc agaaaacctc ctgagggtgt tagagtagac gataattatg 14280 atcataagca agatattcta aaatacgagt ggttcgagtt tactttgcca gaaggcaact 14340 tttcggtcac tatgactatc gacttgatga acaatgccat catagacaat tacttgaaag 14400 tgggcagaca gaatggagtg ttggaaagtg acattggtgt taagttcgac actaggaact 14460 tcaagttggg atgggatcca gaaactaagt tgatcatgcc tggggtttac acctatgagg 14520 ccttccatcc tgacatcgta ttgctgcctg gctgcggagt ggactttacc gaaagccgtc 14580 tgagcaacct tcttggcatt agaaagaaac acccattcca agagggtttt aagatcttgt 14640 atgaggattt agaaggagga aatattccag cccttttgga tgtagatgct tatgagaaca 14700 gcaagaaaga tcaaaaagcc aaaatagaag ctgctgcaga agctaaagca aacatagttg 14760 ccaacgatcc ggtaagggtg gctaacgcta gtgaaatcag gggagacagt tttgccgcaa 14820 catccgttcc gactaaagaa tcattattgg atgatgtgtc tcaaaacata gagttaaaac 14880 tcactattaa gcctgtggaa aaagatggca aaaacagaag ttacaatgtg ttggaagata 14940 aaatcaacac ggcctatcgc agttggtacc tttcgtacaa ttatggcgac cccgaaaaag 15000 gagtgcgttc ctggacattg ctcaccacct cagatgtcac ctgcggagcg gagcaggtct 15060 actggtcgct tccagacatg atgcaggatc ctgtcacttt ccgctccact agacaagtca 15120 gtaactaccc tgtggtgggt gcagagctta tgcccgtctt ttcaaagagc ttctacaacg 15180 aacaagctgt gtactcccag cagctccgcc agtccacctc gcttacgcac gtcttcaacc 15240 gctttcctga gaaccagatt ttaatccgtc cgccggcgcc cacaattacc accgtcagtg 15300 aaaacgttcc tgctctcaca gatcacggga ccctgccgtt gcgcagcagt atccggggag 15360 tccaacgtgt gaccgttact gacgccagac gccgcacctg tccctacgtg tacaaggcac 15420 tgggcatagt cgcaccgcgc gtcctttcaa gccgcacttt ctaaaaaaaa aaaaaaaatg 15480 tccgttctta tctcgcccag taataacacc ggttggggtc tgcgcgctcc cagcaagatg 15540 tacggaggcg cacgcaaacg ttctacccaa catcccgtgc gtgttcgcgg gcattttcgc 15600 gctccatggg gtgccctcaa gggccgcact cgcgttcgaa ccaccgtcga tgatgtaatc 15660 gatcaggtgg ttgccgacgc ccgtaattat actcctactg cgcctacatc tactgtggac 15720 gcagttattg acagtgtagt ggctgacgct cgcaactatg ctcgacgtaa gagccggcga 15780 aggcgcattg ccagacgtca ccgagctacc actgccatgc gagcagcaag agctctgcta 15840 cgaagagcta gacgcgtggg gcgaagagcc atgcttaggg cggccagacg tgcagcttcg 15900 ggcgccagcg ccggcaggtc ccgcaggcaa gcagccgctg tcgcagcggc gactattgcc 15960 gacatggccc aatcgcgaag aggcaatgta tactgggtgc gtgacgctgc caccggtcaa 16020 cgtgtacccg tgcgcacccg tccccctcgc acttagaaga tactgagcag tctccgatgt 16080 tgtgtcccag cggcgaggat gtccaagcgc aaatacaagg aagaaatgct gcaggttatc 16140 gcacctgaag tctacggcca accgttgaag gatgaaaaaa aaccccgcaa aatcaagcgg 16200 gtaaaaaagg acaaaaaaga agaggaagat ggcgatgatg ggctggcgga gtttgtgcgc 16260 gagtttgccc cacggcgacg cgtgcaatgg cgtgggcgca aagttcgaca tgtgttgaga 16320 cctggaactt cggtggtctt tacacccggc gagcgttcaa gcgctacttt taagcgttcc 16380 tatgatgagg tgtacgggga tgatgatatt cttgagcagg cagctgaccg attaggcgag 16440 tttgcttatg gcaagcgtag tagaataaat cccaaggatg aaacagtgtc catacccttg 16500 gatcatggaa atcccacccc tagtcttaaa ccggtcactt tgcagcaagt gttacccgta 16560 actccgcgaa caggtgttaa acgcgaaggt gaagatttgt atcccactat gcaactgatg 16620 gtgcccaaac gccagaagtt ggaggacgtt ttggagaaag taaaagtgga tccagatatt 16680 caacctgagg ttaaagtgag acccattaag caggtagcgc ctggtctggg agtacaaact 16740 gtagacatta aaattcccac tgaaagtatg gaagtgcaaa ctgaacccgc aaagcctact 16800 gccacctcca ctgaagtgca aacggaccca tggatgccca tgcctattac aactgacgcc 16860 gtcggtccca ctcgaagatc ccgacgaaag tacggtccag caagtctgtt gatgcccaac 16920 tatgtcgtac acccatctat tattcctact cctggttacc gaggcactcg ctactatcgc 16980 agccgaaaca gtacttcccg ccgtcgccgc aagacacctg caaatcgcag tcgtcgccgt 17040 agacgcacaa gcaaaccgat tcccggcgcc ctggtgcggc aagtgtaccg caatggtagt 17100 gcggaacctt tgacactgcc gcgtgcgcgt taccatccta gtatcatcac ttaatcaatg 17160 ttgccgctgc ctccttgcag atatggccct cacttgtcgc cttcgcgttc ccatcactgg 17220 ttaccgagga agaaactcgc gccgtagaag agggatgttg gggcgcggaa tgcgacgcta 17280 caggcgacgg cgtgctatcc gcaagcaatt gcggggtggt tttttgccag ccttaattcc 17340 aattatcgct gctgcgattg gcgcaatacc aggcatagct tccgtggcgg ttcaggcctc 17400 gcaacgacat tgacattgga aaaaaaaaaa acgtataaat aaaaaataca atggactctg 17460 acactcctgg tactgtgact atgttttctt agagatggaa gacatcaatt tttcatcctt 17520 ggctccgcga cacggcacga agccgtacat gggcacctgg agcgacatcg gcacgagcca 17580 actgaacggg ggcgccttca attggagcag tatctggagc gggcttaaaa attttggctc 17640 aaccataaaa acatacggga acaaagcttg gaacagcagt acaggacagg cgcttagaaa 17700 taaacttaaa gaccagaact tccaacaaaa agtagtcgat gggatagctt ccggtatcaa 17760 tggagtggta gatttggcta accaggctgt gcagaaaaag ataaacagtc gtttggaccc 17820 gccgccagca accccaggtg aaatgcaagt ggaggaagaa attcctccgc cagaaaaacg 17880 aggcgacaag cgtccgcgtc ccgatttgga agagacgctg gtgacgcgcg tagatgaacc 17940 gccttcttat gaggaagcaa cgaagcttgg aatgcccacc actagaccga tagcccctat 18000 ggccaccggg gtgatgaaac cttctcagtt gcatcgaccc gtcaccttgg atttgccccc 18060 tcctcctgct gctactgctg tacccgcttc taagcctgtc gctgccccga aaccagtcgc 18120 cgtagccagg tcacgtcccg ggggcgctcc tcgtccaaat gcacactggc aaaatactct 18180 gaacagcatc gtgggtctag gcgtgcaaag tgtaaaacgc cgtcgctgct tttaattaaa 18240 tatggagtag cgcttaactt gcctatctgt gtatatgtgt cattacacgc cgtcacagca 18300 tcagaggaaa aaaggaagag gtcgtgcgtc gacgctgagt tactttcaag atggccaccc 18360 catcgatgct gccccaatgg gcatacatgc acatcgccgg acaggatgct tcggagtacc 18420 tgagtccggg tctggtgcag ttcgcccgcg ccacagacac ctacttcaat ctgggaaata 18480 agtttagaaa tcctaccgta gcgccgaccc acgatgtgac caccgatcgt agccagcggc 18540 tcatgttgcg cttcgtgccc gttgaccggg aggacaatac atactcttac aaagtgcggt 18600 acaccctggc cgtgggcgac aacagagtgc tggatatggc cagcacgttc tttgacatta 18660 ggggcgtgtt ggacagaggt cccagtttta aaccctattc tggtacggct tacaactccc 18720 tggctcctaa aggcgctcca aatgcatctc agtggttgga taagggagtt acaagcactg 18780 gcctagtgga cgacggcaat actgatgatg gggaagaagc caaaaaagca acatacactt 18840 ttggtaatgc tccagtaaaa gccgaggctg aaatcacaaa agacggattg ccggtgggct 18900 tggaagtttc aactgaaggt cctaaaccaa tctatgctga taagctttat cagccagaac 18960 ctcaagtggg agacgaaact tggactgacc tagacggaaa aaccgaagag tatggaggga 19020 gggttcttaa acctgaaact aaaatgaaac cctgctacgg atcttttgct aaacctacta 19080 atattaaagg aggtcaggca aaggtaaaac caaaagaaga cgatggcact aacaacatcg 19140 agtatgacat tgacatgaac ttctttgact taagatcaca aagatcagaa ctcaaaccta 19200 aaattgtaat gtatgcagaa aatgtggacc tggaatgtcc agatactcat gttgtgtaca 19260 aacctggagt ttcagatgct agttctgaga ccaatcttgg acaacagtct atgcccaaca 19320 gacccaacta cattggcttc agagataact tcatcggact tatgtactat aacagtactg 19380 gcaacatggg ggtactggct ggccaagcgt ctcagttgaa tgcagtggtt gacttgcagg 19440 acagaaacac agaactgtct taccaactct tgcttgactc tctgggcgac agaaccagat 19500 actttagcat gtggaatcag gctgtggaca gttatgatcc tgatgtacgt gttattgaaa 19560 atcatggtgt ggaagatgaa cttcccaact attgttttcc gttggatggt gtcggtccgc 19620 gaacagatag ttacaaggag attaagccaa atggagacca atctacttgg acaaatgtag 19680 acccaactgg cagcagtgaa cttgctaagg gaaatccatt tgccatggaa attaaccttc 19740 aagccaatct atggcgaagt ttcctttatt ccaatgtggc tctatatctc ccagactcgt 19800 acaaatacac cccgtccaat gtcactcttc cagaaaacaa aaacacctac gactacatga 19860 acgggcgggt ggtgccgcca tctctagtag acacctatgt gaacattggt gccaggtggt 19920 ctctggatgc catggacaat gtcaacccat tcaaccacca ccgtaacgct ggcttgcgtt 19980 accgatccat gcttctgggt aacggacgtt atgtgccttt ccacatacaa gtgcctcaaa 20040 aattcttcgc tgttaaaaac ctgctgcttc tcccaggctc ctacacttat gagtggaact 20100 ttaggaagga tgtaaacatg gttctacaga gttccctcgg taacgaccta cgggtagatg 20160 gcgccagcat cagttttacg agcatcaacc tctatgctac ttttttcccc atggctcaca 20220 acaccgcttc cacccttgaa gccatgctgc ggaatgacac caatgatcag tcattcaacg 20280 actacctatc tgcagctaac atgctctacc ccattcctgc caatgcaacc aatattccca 20340 tttccattcc ttctcgcaac tgggcggctt tcagaggctg gtcatttacc agactgaaaa 20400 ccaaagaaac tccctctttg gggtctggat ttgaccccta cttcgtctat tctggttcta 20460 ttccctacct ggatggtacc ttctacctga accacacttt taagaaggtt tccatcatgt 20520 ttgactcttc agtgagctgg cctggaaatg acaggttact atctcctaac gaatttgaaa 20580 taaagcgcac tgtggatggc gaaggctaca acgtagccca atgcaacatg accaaagact 20640 ggttcttggt acagatgctc gccaactaca acatcggcta tcagggcttc tacattccag 20700 aaggatacaa agatcgcatg tattcatttt tcagaaactt ccagcccatg agcaggcagg 20760 tggttgatga ggtcaattac aaagacttca aggccgtcgc cataccctac caacacaaca 20820 actctggctt tgtgggttac atggctccga ccatgcgtca aggtcaaccc tatcccgcta 20880 actatcccta tccactcatt ggaacaactg ccgtaaatag tgttacgcag aaaaagttct 20940 tgtgtgacag aaccatgtgg cgcataccgt tctcaagcaa cttcatgtct atgggagccc 21000 ttacagactt gggacagaac atgctctatg ccaactcagc tcatgctctg gacatgacct 21060 ttgaggtgga tcccatggat gagcccaccc tgctttatct tctcttcgaa gttttcgacg 21120 tggtcagagt gcatcagcca caccgcggca tcatcgaggc agtctacctg cgtacaccgt 21180 tctcggccgg taacgctacc acgtaagaag cttcttgctt cttgcaaaca gcagctgcaa 21240 ccatggcctg cggatcccaa aacggctcca gcgagcaaga gctcagagcc attgtccaag 21300 acctgggttg cggaccatat tttttgggaa cctttgataa gcgcttcccg gggttcatgg 21360 cccccgataa gctcgcctgt gccattgtaa atacggccgg acgtgagacg gggggagagc 21420 actggttggc tttcggttgg aacccacgtt ctaacacctg ctaccttttt gatccttttg 21480 gattctcgga tgatcgtctc aaacagattt accagtttga atatgagggt ctcctgcgcc 21540 gcagcgctct tgctaccaag gaccggtgta ttacgctgga aaaatctacc cagaccgtgc 21600 agggcccccg ttctgccgcc tgcggacttt tctgctgcat gttccttcat gcctttgtgc 21660 actggcctga ccgtcccatg gacggaaacc ccaccatgaa attgctaact ggagtgccaa 21720 acaacatgct tcattctcct aaagtccagc ccaccctgtg tgacaatcaa aaagcactct 21780 accattttct caatacccat tcgccttatt ttcgctctca tcgtacacac atcgaaaggg 21840 ccactgcgtt cgaccgtatg gatgtgcaat aatgattcat gtaaacaacg tgttcaataa 21900 acagcacttt attttttaca tgtatcgagg ctctggatta cttatttatt tacaagtcga 21960 atgggttctg acgagaatca gaatgacccg caggcagtga tacgttgcgg aactgatact 22020 tgggttgcca cttgaattcg ggaatcacca acttgggaac cggtatatcg ggcaggatgt 22080 cactccacag ctttctggtc agctgcaaag ctcccagcag gtcaggagcc gaaatcttga 22140 aatcacaatt aggaccagtg ctctgagcgc gagagttgcg gtacaccgga ttgcagcact 22200 gaaacaccat cagcgacgga tgtcttacgc ttgccagcac ggtgggatct gcaatcatgc 22260 ccacatccag atcttcagca ttggcaatgc tgaacggggt catcttgcag gtctgcctac 22320 ccatggcggg cacccaatta ggcttgtggt tacaatcgca gtgcaggggg atcagtatca 22380 tcttggcctg atcctgtctg attcctggat acacggctct catgaaagca tcatattgct 22440 tgaaagcctg ctgggcttta ctaccctcgg tataaaacat cccgcaggac ctgctcgaaa 22500 actggttagc tgcgcagccg gcatcattca cacagcagcg ggcgtcattg ttggctattt 22560 gcaccacact tctgccccag cggttttggg tgattttggt tcgctcggga ttctccttca 22620 aggctcgttg tccgttctcg ctggccacat ccatctcgat aatctgctcc ttctgaatca 22680 taatattgcc atgcaagcac ttcagcttgc cctcataatc attgcagcca tgaggccaca 22740 acgcacagcc tgtacattcc caattatggt gggcgatctg agaaaaagaa tgtatcattc 22800 cctgcagaaa tcttcccatc atcgtgctca gtgtcttgtg actagtgaaa gttaactgga 22860 tgcctcggtg ctcctcgttc acgtactggt gacagatgcg cttgtattgt tcgtgctgct 22920 caggcattag tttaaaagag gttctaagtt cgttatccag cctgtacttc tccatcagca 22980 gacacatcac ttccatgcct ttctcccaag cagacaccag gggcaagcta atcggattct 23040 taacagtgca ggcagcagct cctttagcca gagggtcatc tttggcgatc ttctcaatgc 23100 ttcttttgcc atccttctca acgatgcgca cgggcgggta gctgaaaccc actgctacaa 23160 gttgcgcctc ttctctttct tcttcgctgt cttgactgat gtcttgcatg gggacatgtt 23220 tggtcttcct tggcttcttt ttcgggggta tcggaggagg aggactgtcg ctccgttccg 23280 gagacaggga ggattgtgac gtttcgctca ccattaccaa ctgactgtcg gtagaagaac 23340 ctgaccccac acggcgacag gtgtttctct tcgggggcag aggtggaggc gattgcgaag 23400 ggctgcggtc cgacctggaa ggcggatgac tggcagaacc ccttccgcgt tcgggggtgt 23460 gctccctgtg gcggtcgctt aactgatttc cttcgcggct ggccattgtg ttctcctagg 23520 cagagaaaca acagacatgg aaactcagcc attgctgtca acatcgccac gagtgccatc 23580 acatctcgtc ctcagcgacg aggaaaagga gcagagctta agcattccac cgcccagtcc 23640 tgccaccacc tctaccctag aagataagga ggtcgacgca tctcatgaca tgcagaataa 23700 aaaagcgaaa gagtctgagc cagacatcga acaagacccg ggctatgtga caccggtgga 23760 acacgaggaa gagttgaaac gctttctaga gagagaggat gaaaactgcc caaaacagca 23820 agcggataac tatcaccaag atgctggaaa tagggatcag aacaccgact acctcatagg 23880 gcttgacggg gaagacgcgc tccttaaaca tctagcaaga cagtcactca tagtcaagga 23940 tgcattattg gacagaactg aagtgcccat cagtgtcgaa gagctcagcc gcgcctacga 24000 gcttaaccta ttttcacctc gtactccccc caaacgtcag ccaaacggca cctgcgagcc 24060 aaatcctcgc ttaaactttt atccagcttt tgctgtgcca gaagtactgg ctacctatca 24120 catctttttt aaaaatcaaa aaattccagt ctcctgccgc gctaatcgca cccgcgccga 24180 tgccctactc aatctgggac ctggttcacg cttacctgat atagcttcct tggaagaggt 24240 tccaaagatc ttcgagggtc tgggcaataa tgagactcgg gccgcaaatg ctctgcaaaa 24300 gggagaaaat ggcatggatg agcatcacag cgttctggtg gaattggaag gcgataatgc 24360 cagactcgca gtactcaagc gaagcgtcga ggtcacacac tttgcatacc ccgctgtcaa 24420 cctgccccct aaagtcatga cggccgtcat ggaccagtta ctcattaagc gcgcaagtcc 24480 cctttcagaa gacatgcatg acccagatgc ctgtgatgag ggtaaaccag tggtcagtga 24540 tgagcagcta acccgatggc tgggcaccga ctctccccgg gatttggaag agcgtcgcaa 24600 gcttatgatg gccgtggtgc tggttaccgt agaactagag tgtcttcggc gtttctttac 24660 cgattcagaa accttgcgca aactcgaaga gaatctgcac tacactttta gacacggctt 24720 tgtgcggcag gcatgcaaga tatctaacgt ggaactcacc aacctggttt cctacatggg 24780 tattctgcat gagaatcgcc taggacaaag cgtgctgcac agcaccctta agggggaagc 24840 ccgccgtgat tacatccgcg attgtgttta tctctacctg tgccacacgt ggcaaaccgg 24900 catgggtgta tggcagcaat gtttagaaga acagaacctg aaagagctaa acaagctctt 24960 acagaaatct cttaaggttc tgtggacagg gttcgacgag cgcaccgtcg cttccgacct 25020 ggcagacctc atcttcccag agcgtctcag ggttactttg cgaaacggac tgcctgactt 25080 tatgagccag agcatgctta acaattttcg ctctttcatc ctggaacgct ccggtatcct 25140 gcccgccacc tgctgcgcac tgccctccga ctttgtgcct ctcacctacc gcgaatgccc 25200 cccgccgcta tggagtcact gctacctgtt ccgtctggcc aactacctct cctaccactc 25260 ggatgtgatc gaggatgtga gcggagacgg cttgctggag tgtcactgcc gctgcaatct 25320 gtgcacgccc caccggtccc tagcttgcaa cccccagttg atgagcgaaa cccagataat 25380 aggcaccttt gaattgcaag gccccagcag ccaaggcgat gggtcttctc ctgggcaaag 25440 tttaaaactg accccgggac tgtggacctc cgcctacttg cgcaagtttg ccccggaaga 25500 ttaccacccc tatgaaatca agttctatga ggaccaatca cagcctccga aagccgaact 25560 ttcggcctgc gtcatcaccc agggggcaat tctggcccaa ttgcaagcca tccaaaaatc 25620 ccgccaagaa tttctactga aaaagggtaa gggggtctac cttgaccccc agaccggcga 25680 ggaactcaac acaaggttcc ctcaggatgt cccaacgacg agaaagcaag aagttgaagg 25740 tgcagccgcc gcccccagaa gatatggagg aagattggga cagtcaggca gaggaagcgg 25800 aggaggagga cagtctggag gacagtctgg aggaagacag tttggaggag gaaaacgagg 25860 aggcagagga ggtggaagaa gtaaccgccg acaaacagtt atcctcggct gcggagacaa 25920 gcaacagcgc taccatctcc gctccgagtc gaggaacccg gcggcgtccc agcagtagat 25980 gggacgagac cggacgcttc ccgaacccaa ccagcgcttc caagaccggt aagaaggatc 26040 ggcagggata caagtcctgg cgggggcata agaatgccat catctcctgc ttgcatgagt 26100 gcgggggcaa catatccttc acgcggcgct acttgctatt ccaccatggg gtgaactttc 26160 cgcgcaatgt tttgcattac taccgtcacc tccacagccc ctactatagc cagcaaatcc 26220 cggcagtctc gacagataaa gacagcggcg gcgacctcca acagaaaacc agcagcggca 26280 gttagaaaat acacaacaag tgcagcaaca ggaggattaa agattacagc caacgagcca 26340 gcgcaaaccc gagagttaag aaatcggatc tttccaaccc tgtatgccat cttccagcag 26400 agtcggggcc aagagcagga actgaaaata aaaaaccgat ctctgcgttc gctcaccaga 26460 agttgtttgt atcacaagag cgaagatcaa cttcagcgca ctctcgagga cgccgaggct 26520 ctcttcaaca agtactgcgc gctgactctt aaagagtagg cagcgaccgc gcttattcaa 26580 aaaaggcggg aattacatca tcctcgacat gagtaaagaa attcccacgc cttacatgtg 26640 gagttatcag ccccaaatgg gattggcggc aggcgcctcc caggactact ccacccgcat 26700 gaattggctc agcgccgggc cttctatgat ttctcgagtt aatgatatac gcgcctaccg 26760 aaaccaaata cttttggaac agtcagctct taccaccacg ccccgccaac accttaatcc 26820 cagaaattgg cccgccgccc tagtgtacca ggaaagtccc gctcccacca ctgtattact 26880 tcctcgagac gcccaggccg aagtccaaat gactaatgca ggtgcgcagt tagcgggcgg 26940 ctccacccta tgtcgtcaca ggcctcggca taatataaaa cgcctgatga tcagaggccg 27000 aggtatccag ctcaacgacg agtcggtgag ctctccgctt ggtctacgac cagacggaat 27060 ctttcagatt gccggctgcg ggagatcttc cttcacccct cgtcaggctg ttctgacttt 27120 ggaaagttcg tcttcgcaac cccgctcggg cggaatcggg accgttcaat ttgtggagga 27180 gtttactccc tctgtctact tcaacccctt ctccggatct cctgggcact acccggacga 27240 gttcataccg aacttcgacg cgattagcga gtcagtggac ggctacgatt gagtttatgt 27300 taagtggaga ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc cgccacaagt 27360 gctttgcccg cgactccggt gagttttgct actttgaatt gcccgaggat catatcgagg 27420 gcccggcgca cggcgtccgg cttaccgccc agggagagct tgcccgtagc ctgattcggg 27480 agtttaccca gcgccccctg ctagttgagc gggacagggg accctgtgtt ctcactgtga 27540 tttgcaactg tcctaaccct ggattacatc aagatctttg ttgccatctc tgtgctgagt 27600 ataataaata cagaaattaa aatatactgg ggctcctatc gccatcctgt aaacgccacc 27660 gtcttcaccc gcccaagcaa accaaggcga accttacctg gtacttttaa catctctccc 27720 tctgtgattt acaacagttt caacccagac ggagtgagtc tacgagagaa cctctccgag 27780 ctcagctact ccatcagaaa aaacaccacc ctccttacct gccgggaacg tacgagtgcg 27840 tcaccggccg ctgcaccaca cctaccgcct gaccgtaaac cagacttttt ccggacagac 27900 ctcaataact ctgtttacca gaacaggagg tgagcttaga aaacccttag ggtattaggc 27960 caaaggcgca gctactgtgg ggtttatgaa caattcaagc aactctacgg gctattctaa 28020 ttcaggtttc tctagaatcg gggttggggt tattctctgt cttgtgattc tctttattct 28080 tatactaacg cttctctgcc taaggctcgc cgcctgctgt gtgcacattt gcatttattg 28140 tcagcttttt aaacgctggg gtcgccaccc aagatgatta ggtacataat cctaggttta 28200 ctcacccttg cgtcagccca cggtaccacc caaaaggtgg attttaagga gccagcctgt 28260 aatgttacat tcgcagctga agctaatgag tgcaccactc ttataaaatg caccacagaa 28320 catgaaaagc tgcttattcg ccacaaaaac aaaattggca agtatgctgt ttatgctatt 28380 tggcagccag gtgacactac agagtataat gttacagttt tccagggtaa aagtcataaa 28440 acttttatgt atacttttcc attttatgaa atgtgcgaca ttaccatgta catgagcaaa 28500 cagtataagt tgtggccccc acaaaattgt gtggaaaaca ctggcacttt ctgctgcact 28560 gctatgctaa ttacagtgct cgctttggtc tgtaccctac tctatattaa atacaaaagc 28620 agacgcagct ttattgagga aaagaaaatg ccttaattta ctaagttaca aagctaatgt 28680 caccactaac tgctttactc gctgcttgca aaacaaattc aaaaagttag cattataatt 28740 agaataggat ttaaaccccc cggtcatttc ctgctcaata ccattcccct gaacaattga 28800 ctctatgtgg gatatgctcc agcgctacaa ccttgaagtc aggcttcctg gatgtcagca 28860 tctgactttg gccagcacct gtcccgcgga tttgttccag tccaactaca gcgacccacc 28920 ctaacagaga tgaccaacac aaccaacgcg gccgccgcta ccggacttac atctaccaca 28980 aatacacccc aagtttctgc ctttgtcaat aactgggata acttgggcat gtggtggttc 29040 tccatagcgc ttatgtttgt atgccttatt attatgtggc tcatctgctg cctaaagcgc 29100 aaacgcgccc gaccacccat ctatagtccc atcattgtgc tacacccaaa caatgatgga 29160 atccatagat tggacggact gaaacacatg ttcttttctc ttacagtatg attaaatgag 29220 acatgattcc tcgagttttt atattactga cccttgttgc gcttttttgt gcgtgctcca 29280 cattggctgc ggtttctcac atcgaagtag actgcattcc agccttcaca gtctatttgc 29340 tttacggatt tgtcaccctc acgctcatct gcagcctcat cactgtggtc atcgccttta 29400 tccagtgcat tgactgggtc tgtgtgcgct ttgcatatct cagacaccat ccccagtaca 29460 gggacaggac tatagctgag cttcttagaa ttctttaatt atgaaattta ctgtgacttt 29520 tctgctgatt atttgcaccc tatctgcgtt ttgttccccg acctccaagc ctcaaagaca 29580 tatatcatgc agattcactc gtatatggaa tattccaagt tgctacaatg aaaaaagcga 29640 tctttccgaa gcctggttat atgcaatcat ctctgttatg gtgttctgca gtaccatctt 29700 agccctagct atatatccct accttgacat tggctggaac gcaatagatg ccatgaacca 29760 cccaactttc cccgcgcccg ctatgcttcc actgcaacaa gttgttgccg gcggctttgt 29820 cccagccaat cagcctcgcc caccttctcc cacccccact gaaatcagct actttaatct 29880 aacaggagga gatgactgac accctagatc tagaaatgga cggaattatt acagagcagc 29940 gcctgctaga aagacgcagg gcagcggccg agcaacagcg catgaatcaa gagctccaag 30000 acatggttaa cttgcaccag tgcaaaaggg gtatcttttg tctggtaaag caggccaaag 30060 tcacctacga cagtaatacc accggacacc gccttagcta caagttgcca accaagcgtc 30120 agaaattggt ggtcatggtg ggagaaaagc ccattaccat aactcagcac tcggtagaaa 30180 ccgaaggctg cattcactca ccttgtcaag gacctgagga tctctgcacc cttattaaga 30240 ccctgtgcgg tctcaaagat cttattccct ttaactaata aaaaaaaata ataaagctta 30300 atcacttact tgaaatcagc aataaggtct ctgttgaaat tttctcccag cagcacctca 30360 cttccctctt cccaactctg gtattctaaa ccccgttcag cggcatactt tctccatact 30420 ttaaagggga tgtcaaattt tagctcctct cctgtaccca caatcttcat gtctttcttc 30480 ccagatgacc aagagagtcc ggctcagtga ctccttcaac cctgtctacc cctatgaaga 30540 tgaaagcacc tcccaacacc cctttataaa cccagggttt atttccccaa atggcttcac 30600 acaaagccca gacggagttc ttactttaaa atgtttaacc ccactaacaa ccacaggcgg 30660 atctctacag ctaaaagtgg gagggggact tacagtggat gacactgatg gtaccttaca 30720 agaaaacata cgtgctacag cacccattac taaaaataat cactctgtag aactatccat 30780 tggaaatgga ttagaaactc aaaacaataa actatgtgcc aaattgggaa atgggttaaa 30840 atttaacaac ggtgacattt gtataaagga tagtattaac accttatgga ctggaataaa 30900 ccctccacct aactgtcaaa ttgtggaaaa cactaataca aatgatggca aacttacttt 30960 agtattagta aaaaacggag ggcttgttaa tggctacgtg tctctagttg gtgtatcaga 31020 cactgtgaac caaatgttca cacaaaagac agcaaacatc caattaagat tatattttga 31080 ctcttctgga aatctattaa ctgatgaatc agacttaaaa attccactta aaaataaatc 31140 ttctacagcg accagtgaaa ctgtagccag cagcaaagcc tttatgccaa gtactacagc 31200 ttatcccttc aacaccacta ctagggatag tgaaaactac attcatggaa tatgttacta 31260 catgactagt tatgatagaa gtctatttcc cttgaacatt tctataatgc taaacagccg 31320 tatgatttct tccaatgttg cctatgccat acaatttgaa tggaatctaa atgcaagtga 31380 atctccagaa agcaacatag ctacgctgac cacatccccc tttttctttt cttacattac 31440 agaagacgac aactaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat 31500 tgcagaaaat ttcgaatcat ttttcattca gtagtatagc cccaccacca catagcttat 31560 acagatcacc gtaccttaat caaacctaca tgggggtaga gtcataatcg tgcatcagga 31620 tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc tccgtcctgc 31680 aggaatacaa catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc 31740 gccttgtcct ccgggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc 31800 agcacagcac cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca 31860 tggcggggac cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc 31920 gacccctcat aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca 31980 cctcccggta ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc 32040 agctggccaa aacctgcccg ccggctatac actgcaggga accgggactg gaacaatgac 32100 agtggagagc ccaggactcg taaccatgga tcatcatgct cgtcatgata tcaatgttgg 32160 cacaacacag gcacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa 32220 ccatatccca gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac 32280 ctcgcacgta actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat 32340 cctccagtat ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg 32400 gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt catgccaaat ggaacgccgg 32460 acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc 32520 cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca 32580 tccaggcgcc ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata 32640 acatccacca ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca 32700 cacacgggag gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt 32760 atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc 32820 aaactctaca gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa 32880 aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc 32940 ctctataaac attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct 33000 caatatatct ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag 33060 agcgccctcc accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca 33120 cagacctgta taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc 33180 cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc 33240 ccgccaggaa ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg 33300 ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg 33360 ctgctcaaaa aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta gtcatgctca 33420 tgcagataaa ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca 33480 aacatgtctg cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat 33540 tagaagcctg tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca 33600 tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct 33660 cggtcatgtc cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg 33720 tcagtgctaa aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca 33780 acattacagc ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac 33840 ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg 33900 cttccacagc ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa 33960 aacaccactc gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag 34020 agcgagtata tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag 34080 aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa 34140 tcgtcacttc cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca 34200 acacatacaa gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg 34260 ccacgtcaca aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat 34320 tattgatgat g 34331 <210> 86 <211> 35577 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO511) <400> 86 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagct aagtgtcttg ctgtctttat 4080 ttaggggttt tgcgcgcgcg gtaggcccgg gaccagcggt ctcggtcgtt gagggtcctg 4140 tgtatttttt ccaggacgtg gtaaaggtga ctctggatgt tcagatacat gggcataagc 4200 ccgtctctgg ggtggaggta gcaccactgc agagcttcat gctgcggggt ggtgttgtag 4260 atgatccagt cgtagcagga gcgctgggcg tggtgcctaa aaatgtcttt cagtagcaag 4320 ctgattgcca ggggcaggcc cttggtgtaa gtgtttacaa agcggttaag ctgggatggg 4380 tgcatacgtg gggatatgag atgcatcttg gactgtattt ttaggttggc tatgttccca 4440 gccatatccc tccggggatt catgttgtgc agaaccacca gcacagtgta tccggtgcac 4500 ttgggaaatt tgtcatgtag cttagaagga aatgcgtgga agaacttgga gacgcccttg 4560 tgacctccaa gattttccat gcattcgtcc ataatgatgg caatgggccc acgggcggcg 4620 gcctgggcga agatatttct gggatcacta acgtcatagt tgtgttccag gatgagatcg 4680 tcataggcca tttttacaaa gcgcgggcgg agggtgccag actgcggtat aatggttcca 4740 tccggcccag gggcgtagtt accctcacag atttgcattt cccacgcttt gagttcagat 4800 ggggggatca tgtctacctg cggggcgatg aagaaaacgg tttccggggt aggggagatc 4860 agctgggaag aaagcaggtt cctgagcagc tgcgacttac cgcagccggt gggcccgtaa 4920 atcacaccta ttaccgggtg caactggtag ttaagagagc tgcagctgcc gtcatccctg 4980 agcagggggg ccacttcgtt aagcatgtcc ctgactcgca tgttttccct gaccaaatcc 5040 gccagaaggc gctcgccgcc cagcgatagc agttcttgca aggaagcaaa gtttttcaac 5100 ggtttgagac cgtccgccgt aggcatgctt ttgagcgttt gaccaagcag ttccaggcgg 5160 tcccacagct cggtcacctg ctctacggca tctcgatcca gcatatctcc tcgtttcgcg 5220 ggttggggcg gctttcgctg tacggcagta gtcggtgctc gtccagacgg gccagggtca 5280 tgtctttcca cgggcgcagg gtcctcgtca gcgtagtctg ggtcacggtg aaggggtgcg 5340 ctccgggctg cgcgctggcc agggtgcgct tgaggctggt cctgctggtg ctgaagcgct 5400 gccggtcttc gccctgcgcg tcggccaggt agcatttgac catggtgtca tagtccagcc 5460 cctccgcggc gtggcccttg gcgcgcagct tgcccttgga ggaggcgccg cacgaggggc 5520 agtgcagact tttgagggcg tagagcttgg gcgcgagaaa taccgattcc ggggagtagg 5580 catccgcgcc gcaggccccg cagacggtct cgcattccac gagccaggtg agctctggcc 5640 gttcggggtc aaaaaccagg tttcccccat gctttttgat gcgtttctta cctctggttt 5700 ccatgagccg gtgtccacgc tcggtgacga aaaggctgtc cgtgtccccg tatacagact 5760 tgagaggcct gtcctcgagc ggtgttccgc ggtcctcctc gtatagaaac tcggaccact 5820 ctgagacaaa ggctcgcgtc caggccagca cgaaggaggc taagtgggag gggtagcggt 5880 cgttgtccac tagggggtcc actcgctcca gggtgtgaag acacatgtcg ccctcttcgg 5940 catcaaggaa ggtgattggt ttgtaggtgt aggccacgtg accgggtgtt cctgaagggg 6000 ggctataaaa gggggtgggg gcgcgttcgt cctcactctc ttccgcatcg ctgtctgcga 6060 gggccagctg ttggggtgag tactccctct gaaaagcggg catgacttct gcgctaagat 6120 tgtcagtttc caaaaacgag gaggatttga tattcacctg gcccgcggtg atgcctttga 6180 gggtggccgc atccatctgg tcagaaaaga caatcttttt gttgtcaagc ttggtggcaa 6240 acgacccgta gagggcgttg gacagcaact tggcgatgga gcgcagggtt tggtttttgt 6300 cgcgatcggc gcgctccttg gccgcgatgt ttagctgcac gtattcgcgc gcaacgcacc 6360 gccattcggg aaagacggtg gtgcgctcgt cgggcaccag gtgcacgcgc caaccgcggt 6420 tgtgcagggt gacaaggtca acgctggtgg ctacctctcc gcgtaggcgc tcgttggtcc 6480 agcagaggcg gccgcccttg cgcgagcaga atggcggtag ggggtctagc tgcgtctcgt 6540 ccggggggtc tgcgtccacg gtaaagaccc cgggcagcag gcgcgcgtcg aagtagtcta 6600 tcttgcatcc ttgcaagtct agcgcctgct gccatgcgcg ggcggcaagc gcgcgctcgt 6660 atgggttgag tgggggaccc catggcatgg ggtgggtgag cgcggaggcg tacatgccgc 6720 aaatgtcgta aacgtagagg ggctctctga gtattccaag atatgtaggg tagcatcttc 6780 caccgcggat gctggcgcgc acgtaatcgt atagttcgtg cgagggagcg aggaggtcgg 6840 gaccgaggtt gctacgggcg ggctgctctg ctcggaagac tatctgcctg aagatggcat 6900 gtgagttgga tgatatggtt ggacgctgga agacgttgaa gctggcgtct gtgagaccta 6960 ccgcgtcacg cacgaaggag gcgtaggagt cgcgcagctt gttgaccagc tcggcggtga 7020 cctgcacgtc tagggcgcag tagtccaggg tttccttgat gatgtcatac ttatcctgtc 7080 cctttttttt ccacagctcg cggttgagga caaactcttc gcggtctttc cagtactctt 7140 ggatcggaaa cccgtcggcc tccgaacggt aagagcctag catgtagaac tggttgacgg 7200 cctggtaggc gcagcatccc ttttctacgg gtagcgcgta tgcctgcgcg gccttccgga 7260 gcgaggtgtg ggtgagcgca aaggtgtccc tgaccatgac tttgaggtac tggtatttga 7320 agtcagtgtc gtcgcatccg ccctgctccc agagcaaaaa gtccgtgcgc tttttggaac 7380 gcggatttgg cagggcgaag gtgacatcgt tgaagagtat ctttcccgcg cgaggcataa 7440 agttgcgtgt gatgcggaag ggtcccggca cctcggaacg gttgttaatt acctgggcgg 7500 cgagcacgat ctcgtcaaag ccgttgatgt tgtggcccac aatgtaaagt tccaagaagc 7560 gcgggatgcc cttgatggaa ggcaattttt taagttcctc gtaggtgagc tcttcagggg 7620 agctgagccc gtgctctgaa agggcccagt ctgcaagatg agggttggaa gcgacgaatg 7680 agctccacag gtcacgggcc attagcattt gcaggtggtc gcgaaaggtc ctaaactggc 7740 gacctatggc cattttttct ggggtgatgc agtagaaggt aagcgggtct tgttcccagc 7800 ggtcccatcc aaggttcgcg gctaggtctc gcgcggcagt cactagaggc tcatctccgc 7860 cgaacttcat gaccagcatg aagggcacga gctgcttccc aaaggccccc atccaagtat 7920 aggtctctac atcgtaggtg acaaagagac gctcggtgcg aggatgcgag ccgatcggga 7980 agaactggat ctcccgccac caattggagg agtggctatt gatgtggtga aagtagaagt 8040 ccctgcgacg ggccgaacac tcgtgctggc ttttgtaaaa acgtgcgcag tactggcagc 8100 ggtgcacggg ctgtacatcc tgcacgaggt tgacctgacg accgcgcaca aggaagcaga 8160 gtgggaattt gagcccctcg cctggcgggt ttggctggtg gtcttctact tcggctgctt 8220 gtccttgacc gtctggctgc tcgaggggag ttacggtgga tcggaccacc acgccgcgcg 8280 agcccaaagt ccagatgtcc gcgcgcggcg gtcggagctt gatgacaaca tcgcgcagat 8340 gggagctgtc catggtctgg agctcccgcg gcgtcaggtc aggcgggagc tcctgcaggt 8400 ttacctcgca tagacgggtc agggcgcggg ctagatccag gtgataccta atttccaggg 8460 gctggttggt ggcggcgtcg atggcttgca agaggccgca tccccgcggc gcgactacgg 8520 taccgcgcgg cgggcggtgg gccgcggggg tgtccttgga tgatgcatct aaaagcggtg 8580 acgcgggcga gcccccggag gtaggggggg ctccggaccc gccgggagag ggggcagggg 8640 cacgtcggcg ccgcgcgcgg gcaggagctg gtgctgcgcg cgtaggttgc tggcgaacgc 8700 gacgacgcgg cggttgatct cctgaatctg gcgcctctgc gtgaagacga cgggcccggt 8760 gagcttgagc ctgaaagaga gttcgacaga atcaatttcg gtgtcgttga cggcggcctg 8820 gcgcaaaatc tcctgcacgt ctcctgagtt gtcttgatag gcgatctcgg ccatgaactg 8880 ctcgatctct tcctcctgga gatctccgcg tccggctcgc tccacggtgg cggcgaggtc 8940 gttggaaatg cgggccatga gctgcgagaa ggcgttgagg cctccctcgt tccagacgcg 9000 gctgtagacc acgccccctt cggcatcgcg ggcgcgcatg accacctgcg cgagattgag 9060 ctccacgtgc cgggcgaaga cggcgtagtt tcgcaggcgc tgaaagaggt agttgagggt 9120 ggtggcggtg tgttctgcca cgaagaagta cataacccag cgtcgcaacg tggattcgtt 9180 gatatccccc aaggcctcaa ggcgctccat ggcctcgtag aagtccacgg cgaagttgaa 9240 aaactgggag ttgcgcgccg acacggttaa ctcctcctcc agaagacgga tgagctcggc 9300 gacagtgtcg cgcacctcgc gctcaaaggc tacaggggcc tcttcttctt cttcaatctc 9360 ctcttccata agggcctccc cttcttcttc ttctggcggc ggtgggggag gggggacacg 9420 gcggcgacga cggcgcaccg ggaggcggtc gacaaagcgc tcgatcatct ccccgcggcg 9480 acggcgcatg gtctcggtga cggcgcggcc gttctcgcgg gggcgcagtt ggaagacgcc 9540 gcccgtcatg tcccggttat gggttggcgg ggggctgcca tgcggcaggg atacggcgct 9600 aacgatgcat ctcaacaatt gttgtgtagg tactccgccg ccgagggacc tgagcgagtc 9660 cgcatcgacc ggatcggaaa acctctcgag aaaggcgtct aaccagtcac agtcgcaagg 9720 taggctgagc accgtggcgg gcggcagcgg gcggcggtcg gggttgtttc tggcggaggt 9780 gctgctgatg atgtaattaa agtaggcggt cttgagacgg cggatggtcg acagaagcac 9840 catgtccttg ggtccggcct gctgaatgcg caggcggtcg gccatgcccc aggcttcgtt 9900 ttgacatcgg cgcaggtctt tgtagtagtc ttgcatgagc ctttctaccg gcacttcttc 9960 ttctccttcc tcttgtcctg catctcttgc atctatcgct gcggcggcgg cggagtttgg 10020 ccgtaggtgg cgccctcttc ctcccatgcg tgtgaccccg aagcccctca tcggctgaag 10080 cagggctagg tcggcgacaa cgcgctcggc taatatggcc tgctgcacct gcgtgagggt 10140 agactggaag tcatccatgt ccacaaagcg gtggtatgcg cccgtgttga tggtgtaagt 10200 gcagttggcc ataacggacc agttaacggt ctggtgaccc ggctgcgaga gctcggtgta 10260 cctgagacgc gagtaagccc tcgagtcaaa tacgtagtcg ttgcaagtcc gcaccaggta 10320 ctggtatccc accaaaaagt gcggcggcgg ctggcggtag aggggccagc gtagggtggc 10380 cggggctccg ggggcgagat cttccaacat aaggcgatga tatccgtaga tgtacctgga 10440 catccaggtg atgccggcgg cggtggtgga ggcgcgcgga aagtcgcgga cgcggttcca 10500 gatgttgcgc agcggcaaaa agtgctccat ggtcgggacg ctctggccgg tcaggcgcgc 10560 gcaatcgttg acgctctaga ccgtgcaaaa ggagagcctg taagcgggca ctcttccgtg 10620 gtctggtgga taaattcgca agggtatcat ggcggacgac cggggttcga gccccgtatc 10680 cggccgtccg ccgtgatcca tgcggttacc gcccgcgtgt cgaacccagg tgtgcgacgt 10740 cagacaacgg gggagtgctc cttttggctt ccttccaggc gcggcggctg ctgcgctagc 10800 ttttttggcc actggccgcg cgcagcgtaa gcggttaggc tggaaagcga aagcattaag 10860 tggctcgctc cctgtagccg gagggttatt ttccaagggt tgagtcgcgg gacccccggt 10920 tcgagtctcg gaccggccgg actgcggcga acgggggttt gcctccccgt catgcaagac 10980 cccgcttgca aattcctccg gaaacaggga cgagcccctt ttttgctttt cccagatgca 11040 tccggtgctg cggcagatgc gcccccctcc tcagcagcgg caagagcaag agcagcggca 11100 gacatgcagg gcaccctccc ctcctcctac cgcgtcagga ggggcgacat ccgcggttga 11160 cgcggcagca gatggtgatt acgaaccccc gcggcgccgg gcccggcact acctggactt 11220 ggaggagggc gagggcctgg cgcggctagg agcgccctct cctgagcggt acccaagggt 11280 gcagctgaag cgtgatacgc gtgaggcgta cgtgccgcgg cagaacctgt ttcgcgaccg 11340 cgagggagag gagcccgagg agatgcggga tcgaaagttc cacgcagggc gcgagctgcg 11400 gcatggcctg aatcgcgagc ggttgctgcg cgaggaggac tttgagcccg acgcgcgaac 11460 cgggattagt cccgcgcgcg cacacgtggc ggccgccgac ctggtaaccg catacgagca 11520 gacggtgaac caggagatta actttcaaaa aagctttaac aaccacgtgc gtacgcttgt 11580 ggcgcgcgag gaggtggcta taggactgat gcatctgtgg gactttgtaa gcgcgctgga 11640 gcaaaaccca aatagcaagc cgctcatggc gcagctgttc cttatagtgc agcacagcag 11700 ggacaacgag gcattcaggg atgcgctgct aaacatagta gagcccgagg gccgctggct 11760 gctcgatttg ataaacatcc tgcagagcat agtggtgcag gagcgcagct tgagcctggc 11820 tgacaaggtg gccgccatca actattccat gcttagcctg ggcaagtttt acgcccgcaa 11880 gatataccat accccttacg ttcccataga caaggaggta aagatcgagg ggttctacat 11940 gcgcatggcg ctgaaggtgc ttaccttgag cgacgacctg ggcgtttatc gcaacgagcg 12000 catccacaag gccgtgagcg tgagccggcg gcgcgagctc agcgaccgcg agctgatgca 12060 cagcctgcaa agggccctgg ctggcacggg cagcggcgat agagaggccg agtcctactt 12120 tgacgcgggc gctgacctgc gctgggcccc aagccgacgc gccctggagg cagctggggc 12180 cggacctggg ctggcggtgg cacccgcgcg cgctggcaac gtcggcggcg tggaggaata 12240 tgacgaggac gatgagtacg agccagagga cggcgagtac taagcggtga tgtttctgat 12300 cagatgatgc aagacgcaac ggacccggcg gtgcgggcgg cgctgcagag ccagccgtcc 12360 ggccttaact ccacggacga ctggcgccag gtcatggacc gcatcatgtc gctgactgcg 12420 cgcaatcctg acgcgttccg gcagcagccg caggccaacc ggctctccgc aattctggaa 12480 gcggtggtcc cggcgcgcgc aaaccccacg cacgagaagg tgctggcgat cgtaaacgcg 12540 ctggccgaaa acagggccat ccggcccgac gaggccggcc tggtctacga cgcgctgctt 12600 cagcgcgtgg ctcgttacaa cagcggcaac gtgcagacca acctggaccg gctggtgggg 12660 gatgtgcgcg aggccgtggc gcagcgtgag cgcgcgcagc agcagggcaa cctgggctcc 12720 atggttgcac taaacgcctt cctgagtaca cagcccgcca acgtgccgcg gggacaggag 12780 gactacacca actttgtgag cgcactgcgg ctaatggtga ctgagacacc gcaaagtgag 12840 gtgtaccagt ctgggccaga ctattttttc cagaccagta gacaaggcct gcagaccgta 12900 aacctgagcc aggctttcaa aaacttgcag gggctgtggg gggtgcgggc tcccacaggc 12960 gaccgcgcga ccgtgtctag cttgctgacg cccaactcgc gcctgttgct gctgctaata 13020 gcgcccttca cggacagtgg cagcgtgtcc cgggacacat acctaggtca cttgctgaca 13080 ctgtaccgcg aggccatagg tcaggcgcat gtggacgagc atactttcca ggagattaca 13140 agtgtcagcc gcgcgctggg gcaggaggac acgggcagcc tggaggcaac cctaaactac 13200 ctgctgacca accggcggca gaagatcccc tcgttgcaca gtttaaacag cgaggaggag 13260 cgcattttgc gctacgtgca gcagagcgtg agccttaacc tgatgcgcga cggggtaacg 13320 cccagcgtgg cgctggacat gaccgcgcgc aacatggaac cgggcatgta tgcctcaaac 13380 cggccgttta tcaaccgcct aatggactac ttgcatcgcg cggccgccgt gaaccccgag 13440 tatttcacca atgccatctt gaacccgcac tggctaccgc cccctggttt ctacaccggg 13500 ggattcgagg tgcccgaggg taacgatgga ttcctctggg acgacataga cgacagcgtg 13560 ttttccccgc aaccgcagac cctgctagag ttgcaacagc gcgagcaggc agaggcggcg 13620 ctgcgaaagg aaagcttccg caggccaagc agcttgtccg atctaggcgc tgcggccccg 13680 cggtcagatg ctagtagccc atttccaagc ttgatagggt ctcttaccag cactcgcacc 13740 acccgcccgc gcctgctggg cgaggaggag tacctaaaca actcgctgct gcagccgcag 13800 cgcgaaaaaa acctgcctcc ggcatttccc aacaacggga tagagagcct agtggacaag 13860 atgagtagat ggaagacgta cgcgcaggag cacagggacg tgccaggccc gcgcccgccc 13920 acccgtcgtc aaaggcacga ccgtcagcgg ggtctggtgt gggaggacga tgactcggca 13980 gacgacagca gcgtcctgga tttgggaggg agtggcaacc cgtttgcgca ccttcgcccc 14040 aggctgggga gaatgtttta aaaaaaaaaa agcatgatgc aaaataaaaa actcaccaag 14100 gccatggcac cgagcgttgg ttttcttgta ttccccttag tatgcggcgc gcggcgatgt 14160 atgaggaagg tcctcctccc tcctacgaga gtgtggtgag cgcggcgcca gtggcggcgg 14220 cgctgggttc tcccttcgat gctcccctgg acccgccgtt tgtgcctccg cggtacctgc 14280 ggcctaccgg ggggagaaac agcatccgtt actctgagtt ggcaccccta ttcgacacca 14340 cccgtgtgta cctggtggac aacaagtcaa cggatgtggc atccctgaac taccagaacg 14400 accacagcaa ctttctgacc acggtcattc aaaacaatga ctacagcccg ggggaggcaa 14460 gcacacagac catcaatctt gacgaccggt cgcactgggg cggcgacctg aaaaccatcc 14520 tgcataccaa catgccaaat gtgaacgagt tcatgtttac caataagttt aaggcgcggg 14580 tgatggtgtc gcgcttgcct actaaggaca atcaggtgga gctgaaatac gagtgggtgg 14640 agttcacgct gcccgagggc aactactccg agaccatgac catagacctt atgaacaacg 14700 cgatcgtgga gcactacttg aaagtgggca gacagaacgg ggttctggaa agcgacatcg 14760 gggtaaagtt tgacacccgc aacttcagac tggggtttga ccccgtcact ggtcttgtca 14820 tgcctggggt atatacaaac gaagccttcc atccagacat cattttgctg ccaggatgcg 14880 gggtggactt cacccacagc cgcctgagca acttgttggg catccgcaag cggcaaccct 14940 tccaggaggg ctttaggatc acctacgatg atctggaggg tggtaacatt cccgcactgt 15000 tggatgtgga cgcctaccag gcgagcttga aagatgacac cgaacagggc gggggtggcg 15060 caggcggcag caacagcagt ggcagcggcg cggaagagaa ctccaacgcg gcagccgcgg 15120 caatgcagcc ggtggaggac atgaacgatc atgccattcg cggcgaaacc tttgccacac 15180 gggctgagga gaagcgcgct gaggccgaag cagcggccga agctgccgcc cccgctgcgc 15240 aacccgaggt cgagaagcct cagaagaaac cggtgatcaa acccctgaca gaggacagca 15300 agaaacgcag ttacaaccta ataagcaatg acagcacctt cacccagtac cgcagctggt 15360 accttgcata caactacggc gaccctcaga ccggaatccg ctcatggacc ctgctttgca 15420 ctcctgacgt aacctgcggc tcggagcagg tctactggtc gttgccagac atgatgcaag 15480 accccgtgac cttccgctcc acgcgccaga tcagcaactt tccggtggtg ggcgccgagc 15540 tgttgcccgt gcactccaag agcttctaca acgaccaggc cgtctactcc caactcatcc 15600 gccagtttac ctctctgacc cacgtgttca atcgctttcc cgagaaccag attttggcgc 15660 gcccgccagc ccccaccatc accaccgtca gtgaaaacgt tcctgctctc acagatcacg 15720 ggacgctacc gctgcgcaac agcatcggag gagtccagcg agtgaccatt actgacgcca 15780 gacgccgcac ctgcccctac gtttacaagg ccctgggcat agtctcgccg cgcgtcctat 15840 cgagccgcac tttttgagca agcatgtcca tccttatatc gcccagcaat aacacaggct 15900 ggggcctgcg cttcccaagc aagatgtttg gcggggccaa gaagcgctcc gaccaacacc 15960 cagtgcgcgt gcgcgggcac taccgcgcgc cctggggcgc gcacaaacgc ggccgcactg 16020 ggcgcaccac cgtcgatgac gccatcgacg cggtggtgga ggaggcgcgc aactacacgc 16080 ccacgccgcc accagtgtcc acagtggacg cggccattca gaccgtggtg cgcggagccc 16140 ggcgctatgc taaaatgaag agacggcgga ggcgcgtagc acgtcgccac cgccgccgac 16200 ccggcactgc cgcccaacgc gcggcggcgg ccctgcttaa ccgcgcacgt cgcaccggcc 16260 gacgggcggc catgcgggcc gctcgaaggc tggccgcggg tattgtcact gtgcccccca 16320 ggtccaggcg acgagcggcc gccgcagcag ccgcggccat tagtgctatg actcagggtc 16380 gcaggggcaa cgtgtattgg gtgcgcgact cggttagcgg cctgcgcgtg cccgtgcgca 16440 cccgcccccc gcgcaactag attgcaagaa aaaactactt agactcgtac tgttgtatgt 16500 atccagcggc ggcggcgcgc aacgaagcta tgtccaagcg caaaatcaaa gaagagatgc 16560 tccaggtcat cgcgccggag atctatggcc ccccgaagaa ggaagagcag gattacaagc 16620 cccgaaagct aaagcgggtc aaaaagaaaa agaaagatga tgatgatgaa cttgacgacg 16680 aggtggaact gctgcacgct accgcgccca ggcgacgggt acagtggaaa ggtcgacgcg 16740 taaaacgtgt tttgcgaccc ggcaccaccg tagtctttac gcccggtgag cgctccaccc 16800 gcacctacaa gcgcgtgtat gatgaggtgt acggcgacga ggacctgctt gagcaggcca 16860 acgagcgcct cggggagttt gcctacggaa agcggcataa ggacatgctg gcgttgccgc 16920 tggacgaggg caacccaaca cctagcctaa agcccgtaac actgcagcag gtgctgcccg 16980 cgcttgcacc gtccgaagaa aagcgcggcc taaagcgcga gtctggtgac ttggcaccca 17040 ccgtgcagct gatggtaccc aagcgccagc gactggaaga tgtcttggaa aaaatgaccg 17100 tggaacctgg gctggagccc gaggtccgcg tgcggccaat caagcaggtg gcgccgggac 17160 tgggcgtgca gaccgtggac gttcagatac ccactaccag tagcaccagt attgccaccg 17220 ccacagaggg catggagaca caaacgtccc cggttgcctc agcggtggcg gatgccgcgg 17280 tgcaggcggt cgctgcggcc gcgtccaaga cctctacgga ggtgcaaacg gacccgtgga 17340 tgtttcgcgt ttcagccccc cggcgcccgc gcggttcgag gaagtacggc gccgccagcg 17400 cgctactgcc cgaatatgcc ctacatcctt ccattgcgcc tacccccggc tatcgtggct 17460 acacctaccg ccccagaaga cgagcaacta cccgacgccg aaccaccact ggaacccgcc 17520 gccgccgtcg ccgtcgccag cccgtgctgg ccccgatttc cgtgcgcagg gtggctcgcg 17580 aaggaggcag gaccctggtg ctgccaacag cgcgctacca ccccagcatc gtttaaaagc 17640 cggtctttgt ggttcttgca gatatggccc tcacctgccg cctccgtttc ccggtgccgg 17700 gattccgagg aagaatgcac cgtaggaggg gcatggccgg ccacggcctg acgggcggca 17760 tgcgtcgtgc gcaccaccgg cggcggcgcg cgtcgcaccg tcgcatgcgc ggcggtatcc 17820 tgcccctcct tattccactg atcgccgcgg cgattggcgc cgtgcccgga attgcatccg 17880 tggccttgca ggcgcagaga cactgattaa aaacaagttg catgtggaaa aatcaaaata 17940 aaaagtctgg actctcacgc tcgcttggtc ctgtaactat tttgtagaat ggaagacatc 18000 aactttgcgt ctctggcccc gcgacacggc tcgcgcccgt tcatgggaaa ctggcaagat 18060 atcggcacca gcaatatgag cggtggcgcc ttcagctggg gctcgctgtg gagcggcatt 18120 aaaaatttcg gttccaccgt taagaactat ggcagcaagg cctggaacag cagcacaggc 18180 cagatgctga gggataagtt gaaagagcaa aatttccaac aaaaggtggt agatggcctg 18240 gcctctggca ttagcggggt ggtggacctg gccaaccagg cagtgcaaaa taagattaac 18300 agtaagcttg atccccgccc tcccgtagag gagcctccac cggccgtgga gacagtgtct 18360 ccagaggggc gtggcgaaaa gcgtccgcgc cccgacaggg aagaaactct ggtgacgcaa 18420 atagacgagc ctccctcgta cgaggaggca ctaaagcaag gcctgcccac cacccgtccc 18480 atcgcgccca tggctaccgg agtgctgggc cagcacacac ccgtaacgct ggacctgcct 18540 ccccccgccg acacccagca gaaacctgtg ctgccaggcc cgaccgccgt tgttgtaacc 18600 cgtcctagcc gcgcgtccct gcgccgcgcc gccagcggtc cgcgatcgtt gcggcccgta 18660 gccagtggca actggcaaag cacactgaac agcatcgtgg gtctgggggt gcaatccctg 18720 aagcgccgac gatgcttctg aatagctaac gtgtcgtatg tgtgtcatgt atgcgtccat 18780 gtcgccgcca gaggagctgc tgagccgccg cgcgcccgct ttccaagatg gctacccctt 18840 cgatgatgcc gcagtggtct tacatgcaca tctcgggcca ggacgcctcg gagtacctga 18900 gccccgggct ggtgcagttt gcccgcgcca ccgagacgta cttcagcctg aataacaagt 18960 ttagaaaccc cacggtggcg cctacgcacg acgtgaccac agaccggtcc cagcgtttga 19020 cgctgcggtt catccctgtg gaccgtgagg atactgcgta ctcgtacaag gcgcggttca 19080 ccctagctgt gggtgataac cgtgtgctgg acatggcttc cacgtacttt gacatccgcg 19140 gcgtgctgga caggggccct acttttaagc cctactctgg cactgcctac aacgccctgg 19200 ctcccaaggg tgccccaaat ccttgcgaat gggatgaagc tgctactgct cttgaaataa 19260 acctagaaga agaggacgat gacaacgaag acgaagtaga cgagcaagct gagcagcaaa 19320 aaactcacgt atttgggcag gcgccttatt ctggtataaa tattacaaag gagggtattc 19380 aaataggtgt cgaaggtcaa acacctaaat atgccgataa aacatttcaa cctgaacctc 19440 aaataggaga atctcagtgg tacgaaactg aaattaatca tgcagctggg agagtcctta 19500 aaaagactac cccaatgaaa ccatgttacg gttcatatgc aaaacccaca aatgaaaatg 19560 gagggcaagg cattcttgta aagcaacaaa atggaaagct agaaagtcaa gtggaaatgc 19620 aatttttctc aactactgag gcgaccgcag gcaatggtga taacttgact cctaaagtgg 19680 tattgtacag tgaagatgta gatatagaaa ccccagacac tcatatttct tacatgccca 19740 ctattaagga aggtaactca cgagaactaa tgggccaaca atctatgccc aacaggccta 19800 attacattgc ttttagggac aattttattg gtctaatgta ttacaacagc acgggtaata 19860 tgggtgttct ggcgggccaa gcatcgcagt tgaatgctgt tgtagatttg caagacagaa 19920 acacagagct ttcataccag cttttgcttg attccattgg tgatagaacc aggtactttt 19980 ctatgtggaa tcaggctgtt gacagctatg atccagatgt tagaattatt gaaaatcatg 20040 gaactgaaga tgaacttcca aattactgct ttccactggg aggtgtgatt aatacagaga 20100 ctcttaccaa ggtaaaacct aaaacaggtc aggaaaatgg atgggaaaaa gatgctacag 20160 aattttcaga taaaaatcaa ataagagttg gaaataattt tgccatggaa atcaatctaa 20220 atgccaacct gtggagaaat ttcctgtact ccaacatagc gctgtatttg cccgacaagc 20280 taaagtacag tccttccaac gtaaaaattt ctgataaccc aaacacctac gactacatga 20340 acaagcgagt ggtggctccc gggttagtgg actgctacat taaccttgga gcacgctggt 20400 cccttgacta tatggacaac gtcaacccat ttaaccacca ccgcaatgct ggcctgcgct 20460 accgctcaat gttgctgggc aatggtcgct atgtgccctt ccacatccag gtgcctcaga 20520 agttctttgc cattaaaaac ctccttctcc tgccgggctc atacacctac gagtggaact 20580 tcaggaagga tgttaacatg gttctgcaga gctccctagg aaatgaccta agggttgacg 20640 gagccagcat taagtttgat agcatttgcc tttacgccac cttcttcccc atggcccaca 20700 acaccgcctc cacgcttgag gccatgctta gaaacgacac caacgaccag tcctttaacg 20760 actatctctc cgccgccaac atgctctacc ctatacccgc caacgctacc aacgtgccca 20820 tatccatccc ctcccgcaac tgggcggctt tccgcggctg ggccttcacg cgccttaaga 20880 ctaaggaaac cccatcactg ggctcgggct acgaccctta ttacacctac tctggctcta 20940 taccctacct agatggaacc ttttacctca accacacctt taagaaggtg gccattacct 21000 ttgactcttc tgtcagctgg cctggcaatg accgcctgct tacccccaac gagtttgaaa 21060 ttaagcgctc agttgacggg gagggttaca acgttgccca gtgtaacatg accaaagact 21120 ggttcctggt acaaatgcta gctaactaca acattggcta ccagggcttc tatatcccag 21180 agagctacaa ggaccgcatg tactccttct ttagaaactt ccagcccatg agccgtcagg 21240 tggtggatga tactaaatac aaggactacc aacaggtggg catcctacac caacacaaca 21300 actctggatt tgttggctac cttgccccca ccatgcgcga aggacaggcc taccctgcta 21360 acttccccta tccgcttata ggcaagaccg cagttgacag cattacccag aaaaagtttc 21420 tttgcgatcg caccctttgg cgcatcccat tctccagtaa ctttatgtcc atgggcgcac 21480 tcacagacct gggccaaaac cttctctacg ccaactccgc ccacgcgcta gacatgactt 21540 ttgaggtgga tcccatggac gagcccaccc ttctttatgt tttgtttgaa gtctttgacg 21600 tggtccgtgt gcaccggccg caccgcggcg tcatcgaaac cgtgtacctg cgcacgccct 21660 tctcggccgg caacgccaca acataaagaa gcaagcaaca tcaacaacag ctgccgccat 21720 gggctccagt gagcaggaac tgaaagccat tgtcaaagat cttggttgtg ggccatattt 21780 tttgggcacc tatgacaagc gctttccagg ctttgtttct ccacacaagc tcgcctgcgc 21840 catagtcaat acggccggtc gcgagactgg gggcgtacac tggatggcct ttgcctggaa 21900 cccgcactca aaaacatgct acctctttga gccctttggc ttttctgacc agcgactcaa 21960 gcaggtttac cagtttgagt acgagtcact cctgcgccgt agcgccattg cttcttcccc 22020 cgaccgctgt ataacgctgg aaaagtccac ccaaagcgta caggggccca actcggccgc 22080 ctgtggacta ttctgctgca tgtttctcca cgcctttgcc aactggcccc aaactcccat 22140 ggatcacaac cccaccatga accttattac cggggtaccc aactccatgc tcaacagtcc 22200 ccaggtacag cccaccctgc gtcgcaacca ggaacagctc tacagcttcc tggagcgcca 22260 ctcgccctac ttccgcagcc acagtgcgca gattaggagc gccacttctt tttgtcactt 22320 gaaaaacatg taaaaataat gtactagaga cactttcaat aaaggcaaat gcttttattt 22380 gtacactctc gggtgattat ttacccccac ccttgccgtc tgcgccgttt aaaaatcaaa 22440 ggggttctgc cgcgcatcgc tatgcgccac tggcagggac acgttgcgat actggtgttt 22500 agtgctccac ttaaactcag gcacaaccat ccgcggcagc tcggtgaagt tttcactcca 22560 caggctgcgc accatcacca acgcgtttag caggtcgggc gccgatatct tgaagtcgca 22620 gttggggcct ccgccctgcg cgcgcgagtt gcgatacaca gggttgcagc actggaacac 22680 tatcagcgcc gggtggtgca cgctggccag cacgctcttg tcggagatca gatccgcgtc 22740 caggtcctcc gcgttgctca gggcgaacgg agtcaacttt ggtagctgcc ttcccaaaaa 22800 gggcgcgtgc ccaggctttg agttgcactc gcaccgtagt ggcatcaaaa ggtgaccgtg 22860 cccggtctgg gcgttaggat acagcgcctg cataaaagcc ttgatctgct taaaagccac 22920 ctgagccttt gcgccttcag agaagaacat gccgcaagac ttgccggaaa actgattggc 22980 cggacaggcc gcgtcgtgca cgcagcacct tgcgtcggtg ttggagatct gcaccacatt 23040 tcggccccac cggttcttca cgatcttggc cttgctagac tgctccttca gcgcgcgctg 23100 cccgttttcg ctcgtcacat ccatttcaat cacgtgctcc ttatttatca taatgcttcc 23160 gtgtagacac ttaagctcgc cttcgatctc agcgcagcgg tgcagccaca acgcgcagcc 23220 cgtgggctcg tgatgcttgt aggtcacctc tgcaaacgac tgcaggtacg cctgcaggaa 23280 tcgccccatc atcgtcacaa aggtcttgtt gctggtgaag gtcagctgca acccgcggtg 23340 ctcctcgttc agccaggtct tgcatacggc cgccagagct tccacttggt caggcagtag 23400 tttgaagttc gcctttagat cgttatccac gtggtacttg tccatcagcg cgcgcgcagc 23460 ctccatgccc ttctcccacg cagacacgat cggcacactc agcgggttca tcaccgtaat 23520 ttcactttcc gcttcgctgg gctcttcctc ttcctcttgc gtccgcatac cacgcgccac 23580 tgggtcgtct tcattcagcc gccgcactgt gcgcttacct cctttgccat gcttgattag 23640 caccggtggg ttgctgaaac ccaccatttg tagcgccaca tcttctcttt cttcctcgct 23700 gtccacgatt acctctggtg atggcgggcg ctcgggcttg ggagaagggc gcttcttttt 23760 cttcttgggc gcaatggcca aatccgccgc cgaggtcgat ggccgcgggc tgggtgtgcg 23820 cggcaccagc gcgtcttgtg atgagtcttc ctcgtcctcg gactcgatac gccgcctcat 23880 ccgctttttt gggggcgccc ggggaggcgg cggcgacggg gacggggacg acacgtcctc 23940 catggttggg ggacgtcgcg ccgcaccgcg tccgcgctcg ggggtggttt cgcgctgctc 24000 ctcttcccga ctggccattt ccttctccta taggcagaaa aagatcatgg agtcagtcga 24060 gaagaaggac agcctaaccg ccccctctga gttcgccacc accgcctcca ccgatgccgc 24120 caacgcgcct accaccttcc ccgtcgaggc acccccgctt gaggaggagg aagtgattat 24180 cgagcaggac ccaggttttg taagcgaaga cgacgaggac cgctcagtac caacagagga 24240 taaaaagcaa gaccaggaca acgcagaggc aaacgaggaa caagtcgggc ggggggacga 24300 aaggcatggc gactacctag atgtgggaga cgacgtgctg ttgaagcatc tgcagcgcca 24360 gtgcgccatt atctgcgacg cgttgcaaga gcgcagcgat gtgcccctcg ccatagcgga 24420 tgtcagcctt gcctacgaac gccacctatt ctcaccgcgc gtacccccca aacgccaaga 24480 aaacggcaca tgcgagccca acccgcgcct caacttctac cccgtatttg ccgtgccaga 24540 ggtgcttgcc acctatcaca tctttttcca aaactgcaag atacccctat cctgccgtgc 24600 caaccgcagc cgagcggaca agcagctggc cttgcggcag ggcgctgtca tacctgatat 24660 cgcctcgctc aacgaagtgc caaaaatctt tgagggtctt ggacgcgacg agaagcgcgc 24720 ggcaaacgct ctgcaacagg aaaacagcga aaatgaaagt cactctggag tgttggtgga 24780 actcgagggt gacaacgcgc gcctagccgt actaaaacgc agcatcgagg tcacccactt 24840 tgcctacccg gcacttaacc taccccccaa ggtcatgagc acagtcatga gtgagctgat 24900 cgtgcgccgt gcgcagcccc tggagaggga tgcaaatttg caagaacaaa cagaggaggg 24960 cctacccgca gttggcgacg agcagctagc gcgctggctt caaacgcgcg agcctgccga 25020 cttggaggag cgacgcaaac taatgatggc cgcagtgctc gttaccgtgg agcttgagtg 25080 catgcagcgg ttctttgctg acccggagat gcagcgcaag ctagaggaaa cattgcacta 25140 cacctttcga cagggctacg tacgccaggc ctgcaagatc tccaacgtgg agctctgcaa 25200 cctggtctcc taccttggaa ttttgcacga aaaccgcctt gggcaaaacg tgcttcattc 25260 cacgctcaag ggcgaggcgc gccgcgacta cgtccgcgac tgcgtttact tatttctatg 25320 ctacacctgg cagacggcca tgggcgtttg gcagcagtgc ttggaggagt gcaacctcaa 25380 ggagctgcag aaactgctaa agcaaaactt gaaggaccta tggacggcct tcaacgagcg 25440 ctccgtggcc gcgcacctgg cggacatcat tttccccgaa cgcctgctta aaaccctgca 25500 acagggtctg ccagacttca ccagtcaaag catgttgcag aactttagga actttatcct 25560 agagcgctca ggaatcttgc ccgccacctg ctgtgcactt cctagcgact ttgtgcccat 25620 taagtaccgc gaatgccctc cgccgctttg gggccactgc taccttctgc agctagccaa 25680 ctaccttgcc taccactctg acataatgga agacgtgagc ggtgacggtc tactggagtg 25740 tcactgtcgc tgcaacctat gcaccccgca ccgctccctg gtttgcaatt cgcagctgct 25800 taacgaaagt caaattatcg gtacctttga gctgcagggt ccctcgcctg acgaaaagtc 25860 cgcggctccg gggttgaaac tcactccggg gctgtggacg tcggcttacc ttcgcaaatt 25920 tgtacctgag gactaccacg cccacgagat taggttctac gaagaccaat cccgcccgcc 25980 aaatgcggag cttaccgcct gcgtcattac ccagggccac attcttggcc aattgcaagc 26040 catcaacaaa gcccgccaag agtttctgct acgaaaggga cggggggttt acttggaccc 26100 ccagtccggc gaggagctca acccaatccc cccgccgccg cagccctatc agcagcagcc 26160 gcgggccctt gcttcccagg atggcaccca aaaagaagct gcagctgccg ccgccaccca 26220 cggacgagga ggaatactgg gacagtcagg cagaggaggt tttggacgag gaggaggagg 26280 acatgatgga agactgggag agcctagacg aggaagcttc cgaggtcgaa gaggtgtcag 26340 acgaaacacc gtcaccctcg gtcgcattcc cctcgccggc gccccagaaa tcggcaaccg 26400 gttccagcat ggctacaacc tccgctcctc aggcgccgcc ggcactgccc gttcgccgac 26460 ccaaccgtag atgggacacc actggaacca gggccggtaa gtccaagcag ccgccgccgt 26520 tagcccaaga gcaacaacag cgccaaggct accgctcatg gcgcgggcac aagaacgcca 26580 tagttgcttg cttgcaagac tgtgggggca acatctcctt cgcccgccgc tttcttctct 26640 accatcacgg cgtggccttc ccccgtaaca tcctgcatta ctaccgtcat ctctacagcc 26700 catactgcac cggcggcagc ggcagcggca gcaacagcag cggccacaca gaagcaaagg 26760 cgaccggata gcaagactct gacaaagccc aagaaatcca cagcggcggc agcagcagga 26820 ggaggagcgc tgcgtctggc gcccaacgaa cccgtatcga cccgcgagct tagaaacagg 26880 atttttccca ctctgtatgc tatatttcaa cagagcaggg gccaagaaca agagctgaaa 26940 ataaaaaaca ggtctctgcg atccctcacc cgcagctgcc tgtatcacaa aagcgaagat 27000 cagcttcggc gcacgctgga agacgcggag gctctcttca gtaaatactg cgcgctgact 27060 cttaaggact agtttcgcgc cctttctcaa atttaagcgc gaaaactacg tcatctccag 27120 cggccacacc cggcgccagc acctgtcgtc agcgccattt atgagcaagg aaattcccac 27180 gccctacatg tggagttacc agccacaaat gggacttgcg gctggagctg cccaagacta 27240 ctcaacccga ataaactaca tgagcgcggg accccacatg atatcccggg tcaacggaat 27300 acgcgcccac cgaaaccgaa ttctcctgga acaggcggct attaccacca cacctcgtaa 27360 taaccttaat ccccgtagtt ggcccgctgc cctggtgtac caggaaagtc ccgctcccac 27420 cactgtggta cttcccagag acgcccaggc cgaagttcag atgactaact caggggcgca 27480 gcttgcgggc ggctttcgtc acagggtgcg gtcgcccggg cagggtataa ctcacctgac 27540 aatcagaggg cgaggtattc agctcaacga cgagtcggtg agctcctcgc ttggtctccg 27600 tccggacggg acatttcaga tcggcggcgc cggccgctct tcattcacgc ctcgtcaggc 27660 aatcctaact ctgcagacct cgtcctctga gccgcgctct ggaggcattg gaactctgca 27720 atttattgag gagtttgtgc catcggtcta ctttaacccc ttctcgggac ctcccggcca 27780 ctatccggat caatttattc ctaactttga cgcggtaaag gactcggcgg acggctacga 27840 ctgaatgtta agtggagagg cagagcaact gcgcctgaaa cacctggtcc actgtcgccg 27900 ccacaagtgc tttgcccgcg actccggtga gttttgctac tttgaattgc ccgaggatca 27960 tatcgagggc ccggcgcacg gcgtccggct taccgcccag ggagagcttg cccgtagcct 28020 gattcgggag tttacccagc gccccctgct agttgagcgg gacaggggac cctgtgttct 28080 cactgtgatt tgcaactgtc ctaaccctgg attacatcaa gatctttgtt gccatctctg 28140 tgctgagtat aataaataca gaaattaaaa tatactgggg ctcctatcgc catcctgtaa 28200 acgccaccgt cttcacccgc ccaagcaaac caaggcgaac cttacctggt acttttaaca 28260 tctctccctc tgtgatttac aacagtttca acccagacgg agtgagtcta cgagagaacc 28320 tctccgagct cagctactcc atcagaaaaa acaccaccct ccttacctgc cgggaacgta 28380 cgagtgcgtc accggccgct gcaccacacc taccgcctga ccgtaaacca gactttttcc 28440 ggacagacct caataactct gtttaccaga acaggaggtg agcttagaaa acccttaggg 28500 tattaggcca aaggcgcagc tactgtgggg tttatgaaca attcaagcaa ctctacgggc 28560 tattctaatt caggtttctc tagaatcggg gttggggtta ttctctgtct tgtgattctc 28620 tttattctta tactaacgct tctctgccta aggctcgccg cctgctgtgt gcacatttgc 28680 atttattgtc agctttttaa acgctggggt cgccacccaa gatgattagg tacataatcc 28740 taggtttact cacccttgcg tcagcccacg gtaccaccca aaaggtggat tttaaggagc 28800 cagcctgtaa tgttacattc gcagctgaag ctaatgagtg caccactctt ataaaatgca 28860 ccacagaaca tgaaaagctg cttattcgcc acaaaaacaa aattggcaag tatgctgttt 28920 atgctatttg gcagccaggt gacactacag agtataatgt tacagttttc cagggtaaaa 28980 gtcataaaac ttttatgtat acttttccat tttatgaaat gtgcgacatt accatgtaca 29040 tgagcaaaca gtataagttg tggcccccac aaaattgtgt ggaaaacact ggcactttct 29100 gctgcactgc tatgctaatt acagtgctcg ctttggtctg taccctactc tatattaaat 29160 acaaaagcag acgcagcttt attgaggaaa agaaaatgcc ttaatttact aagttacaaa 29220 gctaatgtca ccactaactg ctttactcgc tgcttgcaaa acaaattcaa aaagttagca 29280 ttataattag aataggattt aaaccccccg gtcatttcct gctcaatacc attcccctga 29340 acaattgact ctatgtggga tatgctccag cgctacaacc ttgaagtcag gcttcctgga 29400 tgtcagcatc tgactttggc cagcacctgt cccgcggatt tgttccagtc caactacagc 29460 gacccaccct aacagagatg accaacacaa ccaacgcggc cgccgctacc ggacttacat 29520 ctaccacaaa tacaccccaa gtttctgcct ttgtcaataa ctgggataac ttgggcatgt 29580 ggtggttctc catagcgctt atgtttgtat gccttattat tatgtggctc atctgctgcc 29640 taaagcgcaa acgcgcccga ccacccatct atagtcccat cattgtgcta cacccaaaca 29700 atgatggaat ccatagattg gacggactga aacacatgtt cttttctctt acagtatgat 29760 taaatgagac atggccgttc agctggtgga aagtggcggg ggttctgttc aggcgggcgg 29820 gtctctgagg cttacttgcg ccgcgagtgg tagaaccagt cggagctacg gaatggggtg 29880 gtttaggcaa gctcccggga aagaacgcga atttgtgagc ggcattagct ggcggggcga 29940 ttccactggg tacgcagact ctgtaaaggg aaggtttacc atcagccgcg ataacgcaaa 30000 gaacaccgtt gatctgcaga tgaatagctt gagaccggag gacaccgcca tctactactg 30060 tgcagctgcc gccggaagca catggtatgg gactctgtat gaatacgact actggggcca 30120 gggtacacaa gttaccgtaa gcagcggctc tgggtccggc tcgaccggag tgcaggtgga 30180 aaccatctcc ccaggagacg ggcgcacctt ccccaagcgc ggccagacct gcgtggtgca 30240 ctacaccggg atgcttgaag atggaaagaa atttgattcc tcccgggaca gaaacaagcc 30300 ctttaagttt atgctaggca agcaggaggt gatccgaggc tgggaagaag gggttgccca 30360 gatgagtgtg ggtcagagag ccaaactgac tatatctcca gattatgcct atggtgccac 30420 tgggcaccca ggcatcatcc caccacatgc cactctcgtc ttcgatgtgg agcttctaaa 30480 actgtaataa aaaaaaataa taaagcatca cttacttaaa atcagttagc aaatttctgt 30540 ccagtttatt cagcagcacc tccttgccct cctcccagct ctggtattgc agcttcctcc 30600 tggctgcaaa ctttctccac aatctaaatg gaatgtcagt ttcctcctgt tcctgtccat 30660 ccgcacccac tatcttcatg ttgttgcaga tgaagcgcgc aagaccgtct gaagatacct 30720 tcaaccccgt gtatccatat gacacggaaa ccggtcctcc aactgtgcct tttcttactc 30780 ctccctttgt atcccccaat gggtttcaag agagtccccc tggggtactc tctttgcgcc 30840 tatccgaacc tctagttacc tccaatggca tgcttgcgct caaaatgggc aacggcctct 30900 ctctggacga ggccggcaac cttacctccc aaaatgtaac cactgtgagc ccacctctca 30960 aaaaaaccaa gtcaaacata aacctggaaa tatctgcacc cctcacagtt acctcagaag 31020 ccctaactgt ggctgccgcc gcacctctaa tggtcgcggg caacacactc accatgcaat 31080 cacaggcccc gctaaccgtg cacgactcca aacttagcat tgccacccaa ggacccctca 31140 cagtgtcaga aggaaagcta gccctgcaaa catcaggccc cctcaccacc accgatagca 31200 gtacccttac tatcactgcc tcaccccctc taactactgc cactggtagc ttgggcattg 31260 acttgaaaga gcccatttat acacaaaatg gaaaactagg actaaagtac ggggctcctt 31320 tgcatgtaac agacgaccta aacactttga ccgtagcaac tggtccaggt gtgactatta 31380 ataatacttc cttgcaaact aaagttactg gagccttggg ttttgattca caaggcaata 31440 tgcaacttaa tgtagcagga ggactaagga ttgattctca aaacagacgc cttatacttg 31500 atgttagtta tccgtttgat gctcaaaacc aactaaatct aagactagga cagggccctc 31560 tttttataaa ctcagcccac aacttggata ttaactacaa caaaggcctt tacttgttta 31620 cagcttcaaa caattccaaa aagcttgagg ttaacctaag cactgccaag gggttgatgt 31680 ttgacgctac agccatagcc attaatgcag gagatgggct tgaatttggt tcacctaatg 31740 caccaaacac aaatcccctc aaaacaaaaa ttggccatgg cctagaattt gattcaaaca 31800 aggctatggt tcctaaacta ggaactggcc ttagttttga cagcacaggt gccattacag 31860 taggaaacaa aaataatgat aagctaactt tgtggaccac accagctcca tctcctaact 31920 gtagactaaa tgcagagaaa gatgctaaac tcactttggt cttaacaaaa tgtggcagtc 31980 aaatacttgc tacagtttca gttttggctg ttaaaggcag tttggctcca atatctggaa 32040 cagttcaaag tgctcatctt attataagat ttgacgaaaa tggagtgcta ctaaacaatt 32100 ccttcctgga cccagaatat tggaacttta gaaatggaga tcttactgaa ggcacagcct 32160 atacaaacgc tgttggattt atgcctaacc tatcagctta tccaaaatct cacggtaaaa 32220 ctgccaaaag taacattgtc agtcaagttt acttaaacgg agacaaaact aaacctgtaa 32280 cactaaccat tacactaaac ggtacacagg aaacaggaga cacaactgag atgtggcatg 32340 aaggcctaga agaggcctct cgcttgtact ttggggagag gaacgtcaaa ggcatgtttg 32400 aggtgctgga gcccctgcat gctatgatgg aacgcggtcc ccagaccctg aaggaaacgt 32460 cctttaatca ggcatatggt cgagatttaa tggaggcaca agaatggtgc cgaaagtaca 32520 tgaaatcagg gaacgtcaag gacctcctcc aagcctggga cctctactat cacgtgttca 32580 gacgaatctc aaagcagcca agtgcatact ctatgtcatt ttcatgggac tggtctggcc 32640 acaactacat taatgaaata tttgccacat cctcttacac tttttcatac attgcccaag 32700 aataaagaat cgtttgtgtt atgtttcaac gtgtttattt ttcaattgca gaaaatttcg 32760 aatcattttt cattcagtag tatagcccca ccaccacata gcttatacag atcaccgtac 32820 cttaatcaaa cctacatggg ggtagagtca taatcgtgca tcaggatagg gcggtggtgc 32880 tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga atacaacatg 32940 gcagtggtct cctcagcgat gattcgcacc gcccgcagca taaggcgcct tgtcctccgg 33000 gcacagcagc gcaccctgat ctcacttaaa tcagcacagt aactgcagca cagcaccaca 33060 atattgttca aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc ggggaccaca 33120 gaacccacgt ggccatcata ccacaagcgc aggtagatta agtggcgacc cctcataaac 33180 acgctggaca taaacattac ctcttttggc atgttgtaat tcaccacctc ccggtaccat 33240 ataaacctct gattaaacat ggcgccatcc accaccatcc taaaccagct ggccaaaacc 33300 tgcccgccgg ctatacactg cagggaaccg ggactggaac aatgacagtg gagagcccag 33360 gactcgtaac catggatcat catgctcgtc atgatatcaa tgttggcaca acacaggcac 33420 acgtgcatac acttcctcag gattacaagc tcctcccgcg ttagaaccat atcccaggga 33480 acaacccatt cctgaatcag cgtaaatccc acactgcagg gaagacctcg cacgtaactc 33540 acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc cagtatggta 33600 gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac tgtacggagt gcgccgagac 33660 aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt agtcatattt 33720 cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg cgtctccggt ctcgccgctt 33780 agatcgctct gtgtagtagt tgtagtatat ccactctctc aaagcatcca ggcgccccct 33840 ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc ctgataacat ccaccaccgc 33900 agaataagcc acacccagcc aacctacaca ttcgttctgc gagtcacaca cgggaggagc 33960 gggaagagct ggaagaacca tgtttttttt tttattccaa aagattatcc aaaacctcaa 34020 aatgaagatc tattaagtga acgcgctccc ctccggtggc gtggtcaaac tctacagcca 34080 aagaacagat aatggcattt gtaagatgtt gcacaatggc ttccaaaagg caaacggccc 34140 tcacgtccaa gtggacgtaa aggctaaacc cttcagggtg aatctcctct ataaacattc 34200 cagcaccttc aaccatgccc aaataattct catctcgcca ccttctcaat atatctctaa 34260 gcaaatcccg aatattaagt ccggccattg taaaaatctg ctccagagcg ccctccacct 34320 tcagcctcaa gcagcgaatc atgattgcaa aaattcaggt tcctcacaga cctgtataag 34380 attcaaaagc ggaacattaa caaaaatacc gcgatcccgt aggtcccttc gcagggccag 34440 ctgaacataa tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc caggaaccat 34500 gacaaaagaa cccacactga ttatgacacg catactcgga gctatgctaa ccagcgtagc 34560 cccgatgtaa gcttgttgca tgggcggcga tataaaatgc aaggtgctgc tcaaaaaatc 34620 aggcaaagcc tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca gataaaggca 34680 ggtaagctcc ggaaccacca cagaaaaaga caccattttt ctctcaaaca tgtctgcggg 34740 tttctgcata aacacaaaat aaaataacaa aaaaacattt aaacattaga agcctgtctt 34800 acaacaggaa aaacaaccct tataagcata agacggacta cggccatgcc ggcgtgaccg 34860 taaaaaaact ggtcaccgtg attaaaaagc accaccgaca gctcctcggt catgtccgga 34920 gtcataatgt aagactcggt aaacacatca ggttgattca catcggtcag tgctaaaaag 34980 cgaccgaaat agcccggggg aatacatacc cgcaggcgta gagacaacat tacagccccc 35040 ataggaggta taacaaaatt aataggagag aaaaacacat aaacacctga aaaaccctcc 35100 tgcctaggca aaatagcacc ctcccgctcc agaacaacat acagcgcttc cacagcggca 35160 gccataacag tcagccttac cagtaaaaaa gaaaacctat taaaaaaaca ccactcgaca 35220 cggcaccagc tcaatcagtc acagtgtaaa aaagggccaa gtgcagagcg agtatatata 35280 ggactaaaaa atgacgtaac ggttaaagtc cacaaaaaac acccagaaaa ccgcacgcga 35340 acctacgccc agaaacgaaa gccaaaaaac ccacaacttc ctcaaatcgt cacttccgtt 35400 ttcccacgtt acgtcacttc ccattttaag aaaactacaa ttcccaacac atacaagtta 35460 ctccgcccta aaacctacgt cacccgcccc gttcccacgc cccgcgccac gtcacaaact 35520 ccaccccctc attatcatat tggcttcaat ccaaaataag gtatattatt gatgatg 35577 <210> 87 <211> 35673 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO512) <400> 87 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccatgagca 3600 ccaactcgtt tgatggaagc attgtgagct catatttgac aacgcgcatg cccccatggg 3660 ccggggtgcg tcagaatgtg atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa 3720 actctactac cttgacctac gagaccgtgt ctggaacgcc gttggagact gcagcctccg 3780 ccgccgcttc agccgctgca gccaccgccc gcgggattgt gactgacttt gctttcctga 3840 gcccgcttgc aagcagtgca gcttcccgtt catccgcccg cgatgacaag ttgacggctc 3900 ttttggcaca attggattct ttgacccggg aacttaatgt cgtttctcag cagctgttgg 3960 atctgcgcca gcaggtttct gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagct aagtgtcttg ctgtctttat 4080 ttaggggttt tgcgcgcgcg gtaggcccgg gaccagcggt ctcggtcgtt gagggtcctg 4140 tgtatttttt ccaggacgtg gtaaaggtga ctctggatgt tcagatacat gggcataagc 4200 ccgtctctgg ggtggaggta gcaccactgc agagcttcat gctgcggggt ggtgttgtag 4260 atgatccagt cgtagcagga gcgctgggcg tggtgcctaa aaatgtcttt cagtagcaag 4320 ctgattgcca ggggcaggcc cttggtgtaa gtgtttacaa agcggttaag ctgggatggg 4380 tgcatacgtg gggatatgag atgcatcttg gactgtattt ttaggttggc tatgttccca 4440 gccatatccc tccggggatt catgttgtgc agaaccacca gcacagtgta tccggtgcac 4500 ttgggaaatt tgtcatgtag cttagaagga aatgcgtgga agaacttgga gacgcccttg 4560 tgacctccaa gattttccat gcattcgtcc ataatgatgg caatgggccc acgggcggcg 4620 gcctgggcga agatatttct gggatcacta acgtcatagt tgtgttccag gatgagatcg 4680 tcataggcca tttttacaaa gcgcgggcgg agggtgccag actgcggtat aatggttcca 4740 tccggcccag gggcgtagtt accctcacag atttgcattt cccacgcttt gagttcagat 4800 ggggggatca tgtctacctg cggggcgatg aagaaaacgg tttccggggt aggggagatc 4860 agctgggaag aaagcaggtt cctgagcagc tgcgacttac cgcagccggt gggcccgtaa 4920 atcacaccta ttaccgggtg caactggtag ttaagagagc tgcagctgcc gtcatccctg 4980 agcagggggg ccacttcgtt aagcatgtcc ctgactcgca tgttttccct gaccaaatcc 5040 gccagaaggc gctcgccgcc cagcgatagc agttcttgca aggaagcaaa gtttttcaac 5100 ggtttgagac cgtccgccgt aggcatgctt ttgagcgttt gaccaagcag ttccaggcgg 5160 tcccacagct cggtcacctg ctctacggca tctcgatcca gcatatctcc tcgtttcgcg 5220 ggttggggcg gctttcgctg tacggcagta gtcggtgctc gtccagacgg gccagggtca 5280 tgtctttcca cgggcgcagg gtcctcgtca gcgtagtctg ggtcacggtg aaggggtgcg 5340 ctccgggctg cgcgctggcc agggtgcgct tgaggctggt cctgctggtg ctgaagcgct 5400 gccggtcttc gccctgcgcg tcggccaggt agcatttgac catggtgtca tagtccagcc 5460 cctccgcggc gtggcccttg gcgcgcagct tgcccttgga ggaggcgccg cacgaggggc 5520 agtgcagact tttgagggcg tagagcttgg gcgcgagaaa taccgattcc ggggagtagg 5580 catccgcgcc gcaggccccg cagacggtct cgcattccac gagccaggtg agctctggcc 5640 gttcggggtc aaaaaccagg tttcccccat gctttttgat gcgtttctta cctctggttt 5700 ccatgagccg gtgtccacgc tcggtgacga aaaggctgtc cgtgtccccg tatacagact 5760 tgagaggcct gtcctcgagc ggtgttccgc ggtcctcctc gtatagaaac tcggaccact 5820 ctgagacaaa ggctcgcgtc caggccagca cgaaggaggc taagtgggag gggtagcggt 5880 cgttgtccac tagggggtcc actcgctcca gggtgtgaag acacatgtcg ccctcttcgg 5940 catcaaggaa ggtgattggt ttgtaggtgt aggccacgtg accgggtgtt cctgaagggg 6000 ggctataaaa gggggtgggg gcgcgttcgt cctcactctc ttccgcatcg ctgtctgcga 6060 gggccagctg ttggggtgag tactccctct gaaaagcggg catgacttct gcgctaagat 6120 tgtcagtttc caaaaacgag gaggatttga tattcacctg gcccgcggtg atgcctttga 6180 gggtggccgc atccatctgg tcagaaaaga caatcttttt gttgtcaagc ttggtggcaa 6240 acgacccgta gagggcgttg gacagcaact tggcgatgga gcgcagggtt tggtttttgt 6300 cgcgatcggc gcgctccttg gccgcgatgt ttagctgcac gtattcgcgc gcaacgcacc 6360 gccattcggg aaagacggtg gtgcgctcgt cgggcaccag gtgcacgcgc caaccgcggt 6420 tgtgcagggt gacaaggtca acgctggtgg ctacctctcc gcgtaggcgc tcgttggtcc 6480 agcagaggcg gccgcccttg cgcgagcaga atggcggtag ggggtctagc tgcgtctcgt 6540 ccggggggtc tgcgtccacg gtaaagaccc cgggcagcag gcgcgcgtcg aagtagtcta 6600 tcttgcatcc ttgcaagtct agcgcctgct gccatgcgcg ggcggcaagc gcgcgctcgt 6660 atgggttgag tgggggaccc catggcatgg ggtgggtgag cgcggaggcg tacatgccgc 6720 aaatgtcgta aacgtagagg ggctctctga gtattccaag atatgtaggg tagcatcttc 6780 caccgcggat gctggcgcgc acgtaatcgt atagttcgtg cgagggagcg aggaggtcgg 6840 gaccgaggtt gctacgggcg ggctgctctg ctcggaagac tatctgcctg aagatggcat 6900 gtgagttgga tgatatggtt ggacgctgga agacgttgaa gctggcgtct gtgagaccta 6960 ccgcgtcacg cacgaaggag gcgtaggagt cgcgcagctt gttgaccagc tcggcggtga 7020 cctgcacgtc tagggcgcag tagtccaggg tttccttgat gatgtcatac ttatcctgtc 7080 cctttttttt ccacagctcg cggttgagga caaactcttc gcggtctttc cagtactctt 7140 ggatcggaaa cccgtcggcc tccgaacggt aagagcctag catgtagaac tggttgacgg 7200 cctggtaggc gcagcatccc ttttctacgg gtagcgcgta tgcctgcgcg gccttccgga 7260 gcgaggtgtg ggtgagcgca aaggtgtccc tgaccatgac tttgaggtac tggtatttga 7320 agtcagtgtc gtcgcatccg ccctgctccc agagcaaaaa gtccgtgcgc tttttggaac 7380 gcggatttgg cagggcgaag gtgacatcgt tgaagagtat ctttcccgcg cgaggcataa 7440 agttgcgtgt gatgcggaag ggtcccggca cctcggaacg gttgttaatt acctgggcgg 7500 cgagcacgat ctcgtcaaag ccgttgatgt tgtggcccac aatgtaaagt tccaagaagc 7560 gcgggatgcc cttgatggaa ggcaattttt taagttcctc gtaggtgagc tcttcagggg 7620 agctgagccc gtgctctgaa agggcccagt ctgcaagatg agggttggaa gcgacgaatg 7680 agctccacag gtcacgggcc attagcattt gcaggtggtc gcgaaaggtc ctaaactggc 7740 gacctatggc cattttttct ggggtgatgc agtagaaggt aagcgggtct tgttcccagc 7800 ggtcccatcc aaggttcgcg gctaggtctc gcgcggcagt cactagaggc tcatctccgc 7860 cgaacttcat gaccagcatg aagggcacga gctgcttccc aaaggccccc atccaagtat 7920 aggtctctac atcgtaggtg acaaagagac gctcggtgcg aggatgcgag ccgatcggga 7980 agaactggat ctcccgccac caattggagg agtggctatt gatgtggtga aagtagaagt 8040 ccctgcgacg ggccgaacac tcgtgctggc ttttgtaaaa acgtgcgcag tactggcagc 8100 ggtgcacggg ctgtacatcc tgcacgaggt tgacctgacg accgcgcaca aggaagcaga 8160 gtgggaattt gagcccctcg cctggcgggt ttggctggtg gtcttctact tcggctgctt 8220 gtccttgacc gtctggctgc tcgaggggag ttacggtgga tcggaccacc acgccgcgcg 8280 agcccaaagt ccagatgtcc gcgcgcggcg gtcggagctt gatgacaaca tcgcgcagat 8340 gggagctgtc catggtctgg agctcccgcg gcgtcaggtc aggcgggagc tcctgcaggt 8400 ttacctcgca tagacgggtc agggcgcggg ctagatccag gtgataccta atttccaggg 8460 gctggttggt ggcggcgtcg atggcttgca agaggccgca tccccgcggc gcgactacgg 8520 taccgcgcgg cgggcggtgg gccgcggggg tgtccttgga tgatgcatct aaaagcggtg 8580 acgcgggcga gcccccggag gtaggggggg ctccggaccc gccgggagag ggggcagggg 8640 cacgtcggcg ccgcgcgcgg gcaggagctg gtgctgcgcg cgtaggttgc tggcgaacgc 8700 gacgacgcgg cggttgatct cctgaatctg gcgcctctgc gtgaagacga cgggcccggt 8760 gagcttgagc ctgaaagaga gttcgacaga atcaatttcg gtgtcgttga cggcggcctg 8820 gcgcaaaatc tcctgcacgt ctcctgagtt gtcttgatag gcgatctcgg ccatgaactg 8880 ctcgatctct tcctcctgga gatctccgcg tccggctcgc tccacggtgg cggcgaggtc 8940 gttggaaatg cgggccatga gctgcgagaa ggcgttgagg cctccctcgt tccagacgcg 9000 gctgtagacc acgccccctt cggcatcgcg ggcgcgcatg accacctgcg cgagattgag 9060 ctccacgtgc cgggcgaaga cggcgtagtt tcgcaggcgc tgaaagaggt agttgagggt 9120 ggtggcggtg tgttctgcca cgaagaagta cataacccag cgtcgcaacg tggattcgtt 9180 gatatccccc aaggcctcaa ggcgctccat ggcctcgtag aagtccacgg cgaagttgaa 9240 aaactgggag ttgcgcgccg acacggttaa ctcctcctcc agaagacgga tgagctcggc 9300 gacagtgtcg cgcacctcgc gctcaaaggc tacaggggcc tcttcttctt cttcaatctc 9360 ctcttccata agggcctccc cttcttcttc ttctggcggc ggtgggggag gggggacacg 9420 gcggcgacga cggcgcaccg ggaggcggtc gacaaagcgc tcgatcatct ccccgcggcg 9480 acggcgcatg gtctcggtga cggcgcggcc gttctcgcgg gggcgcagtt ggaagacgcc 9540 gcccgtcatg tcccggttat gggttggcgg ggggctgcca tgcggcaggg atacggcgct 9600 aacgatgcat ctcaacaatt gttgtgtagg tactccgccg ccgagggacc tgagcgagtc 9660 cgcatcgacc ggatcggaaa acctctcgag aaaggcgtct aaccagtcac agtcgcaagg 9720 taggctgagc accgtggcgg gcggcagcgg gcggcggtcg gggttgtttc tggcggaggt 9780 gctgctgatg atgtaattaa agtaggcggt cttgagacgg cggatggtcg acagaagcac 9840 catgtccttg ggtccggcct gctgaatgcg caggcggtcg gccatgcccc aggcttcgtt 9900 ttgacatcgg cgcaggtctt tgtagtagtc ttgcatgagc ctttctaccg gcacttcttc 9960 ttctccttcc tcttgtcctg catctcttgc atctatcgct gcggcggcgg cggagtttgg 10020 ccgtaggtgg cgccctcttc ctcccatgcg tgtgaccccg aagcccctca tcggctgaag 10080 cagggctagg tcggcgacaa cgcgctcggc taatatggcc tgctgcacct gcgtgagggt 10140 agactggaag tcatccatgt ccacaaagcg gtggtatgcg cccgtgttga tggtgtaagt 10200 gcagttggcc ataacggacc agttaacggt ctggtgaccc ggctgcgaga gctcggtgta 10260 cctgagacgc gagtaagccc tcgagtcaaa tacgtagtcg ttgcaagtcc gcaccaggta 10320 ctggtatccc accaaaaagt gcggcggcgg ctggcggtag aggggccagc gtagggtggc 10380 cggggctccg ggggcgagat cttccaacat aaggcgatga tatccgtaga tgtacctgga 10440 catccaggtg atgccggcgg cggtggtgga ggcgcgcgga aagtcgcgga cgcggttcca 10500 gatgttgcgc agcggcaaaa agtgctccat ggtcgggacg ctctggccgg tcaggcgcgc 10560 gcaatcgttg acgctctaga ccgtgcaaaa ggagagcctg taagcgggca ctcttccgtg 10620 gtctggtgga taaattcgca agggtatcat ggcggacgac cggggttcga gccccgtatc 10680 cggccgtccg ccgtgatcca tgcggttacc gcccgcgtgt cgaacccagg tgtgcgacgt 10740 cagacaacgg gggagtgctc cttttggctt ccttccaggc gcggcggctg ctgcgctagc 10800 ttttttggcc actggccgcg cgcagcgtaa gcggttaggc tggaaagcga aagcattaag 10860 tggctcgctc cctgtagccg gagggttatt ttccaagggt tgagtcgcgg gacccccggt 10920 tcgagtctcg gaccggccgg actgcggcga acgggggttt gcctccccgt catgcaagac 10980 cccgcttgca aattcctccg gaaacaggga cgagcccctt ttttgctttt cccagatgca 11040 tccggtgctg cggcagatgc gcccccctcc tcagcagcgg caagagcaag agcagcggca 11100 gacatgcagg gcaccctccc ctcctcctac cgcgtcagga ggggcgacat ccgcggttga 11160 cgcggcagca gatggtgatt acgaaccccc gcggcgccgg gcccggcact acctggactt 11220 ggaggagggc gagggcctgg cgcggctagg agcgccctct cctgagcggt acccaagggt 11280 gcagctgaag cgtgatacgc gtgaggcgta cgtgccgcgg cagaacctgt ttcgcgaccg 11340 cgagggagag gagcccgagg agatgcggga tcgaaagttc cacgcagggc gcgagctgcg 11400 gcatggcctg aatcgcgagc ggttgctgcg cgaggaggac tttgagcccg acgcgcgaac 11460 cgggattagt cccgcgcgcg cacacgtggc ggccgccgac ctggtaaccg catacgagca 11520 gacggtgaac caggagatta actttcaaaa aagctttaac aaccacgtgc gtacgcttgt 11580 ggcgcgcgag gaggtggcta taggactgat gcatctgtgg gactttgtaa gcgcgctgga 11640 gcaaaaccca aatagcaagc cgctcatggc gcagctgttc cttatagtgc agcacagcag 11700 ggacaacgag gcattcaggg atgcgctgct aaacatagta gagcccgagg gccgctggct 11760 gctcgatttg ataaacatcc tgcagagcat agtggtgcag gagcgcagct tgagcctggc 11820 tgacaaggtg gccgccatca actattccat gcttagcctg ggcaagtttt acgcccgcaa 11880 gatataccat accccttacg ttcccataga caaggaggta aagatcgagg ggttctacat 11940 gcgcatggcg ctgaaggtgc ttaccttgag cgacgacctg ggcgtttatc gcaacgagcg 12000 catccacaag gccgtgagcg tgagccggcg gcgcgagctc agcgaccgcg agctgatgca 12060 cagcctgcaa agggccctgg ctggcacggg cagcggcgat agagaggccg agtcctactt 12120 tgacgcgggc gctgacctgc gctgggcccc aagccgacgc gccctggagg cagctggggc 12180 cggacctggg ctggcggtgg cacccgcgcg cgctggcaac gtcggcggcg tggaggaata 12240 tgacgaggac gatgagtacg agccagagga cggcgagtac taagcggtga tgtttctgat 12300 cagatgatgc aagacgcaac ggacccggcg gtgcgggcgg cgctgcagag ccagccgtcc 12360 ggccttaact ccacggacga ctggcgccag gtcatggacc gcatcatgtc gctgactgcg 12420 cgcaatcctg acgcgttccg gcagcagccg caggccaacc ggctctccgc aattctggaa 12480 gcggtggtcc cggcgcgcgc aaaccccacg cacgagaagg tgctggcgat cgtaaacgcg 12540 ctggccgaaa acagggccat ccggcccgac gaggccggcc tggtctacga cgcgctgctt 12600 cagcgcgtgg ctcgttacaa cagcggcaac gtgcagacca acctggaccg gctggtgggg 12660 gatgtgcgcg aggccgtggc gcagcgtgag cgcgcgcagc agcagggcaa cctgggctcc 12720 atggttgcac taaacgcctt cctgagtaca cagcccgcca acgtgccgcg gggacaggag 12780 gactacacca actttgtgag cgcactgcgg ctaatggtga ctgagacacc gcaaagtgag 12840 gtgtaccagt ctgggccaga ctattttttc cagaccagta gacaaggcct gcagaccgta 12900 aacctgagcc aggctttcaa aaacttgcag gggctgtggg gggtgcgggc tcccacaggc 12960 gaccgcgcga ccgtgtctag cttgctgacg cccaactcgc gcctgttgct gctgctaata 13020 gcgcccttca cggacagtgg cagcgtgtcc cgggacacat acctaggtca cttgctgaca 13080 ctgtaccgcg aggccatagg tcaggcgcat gtggacgagc atactttcca ggagattaca 13140 agtgtcagcc gcgcgctggg gcaggaggac acgggcagcc tggaggcaac cctaaactac 13200 ctgctgacca accggcggca gaagatcccc tcgttgcaca gtttaaacag cgaggaggag 13260 cgcattttgc gctacgtgca gcagagcgtg agccttaacc tgatgcgcga cggggtaacg 13320 cccagcgtgg cgctggacat gaccgcgcgc aacatggaac cgggcatgta tgcctcaaac 13380 cggccgttta tcaaccgcct aatggactac ttgcatcgcg cggccgccgt gaaccccgag 13440 tatttcacca atgccatctt gaacccgcac tggctaccgc cccctggttt ctacaccggg 13500 ggattcgagg tgcccgaggg taacgatgga ttcctctggg acgacataga cgacagcgtg 13560 ttttccccgc aaccgcagac cctgctagag ttgcaacagc gcgagcaggc agaggcggcg 13620 ctgcgaaagg aaagcttccg caggccaagc agcttgtccg atctaggcgc tgcggccccg 13680 cggtcagatg ctagtagccc atttccaagc ttgatagggt ctcttaccag cactcgcacc 13740 acccgcccgc gcctgctggg cgaggaggag tacctaaaca actcgctgct gcagccgcag 13800 cgcgaaaaaa acctgcctcc ggcatttccc aacaacggga tagagagcct agtggacaag 13860 atgagtagat ggaagacgta cgcgcaggag cacagggacg tgccaggccc gcgcccgccc 13920 acccgtcgtc aaaggcacga ccgtcagcgg ggtctggtgt gggaggacga tgactcggca 13980 gacgacagca gcgtcctgga tttgggaggg agtggcaacc cgtttgcgca ccttcgcccc 14040 aggctgggga gaatgtttta aaaaaaaaaa agcatgatgc aaaataaaaa actcaccaag 14100 gccatggcac cgagcgttgg ttttcttgta ttccccttag tatgcggcgc gcggcgatgt 14160 atgaggaagg tcctcctccc tcctacgaga gtgtggtgag cgcggcgcca gtggcggcgg 14220 cgctgggttc tcccttcgat gctcccctgg acccgccgtt tgtgcctccg cggtacctgc 14280 ggcctaccgg ggggagaaac agcatccgtt actctgagtt ggcaccccta ttcgacacca 14340 cccgtgtgta cctggtggac aacaagtcaa cggatgtggc atccctgaac taccagaacg 14400 accacagcaa ctttctgacc acggtcattc aaaacaatga ctacagcccg ggggaggcaa 14460 gcacacagac catcaatctt gacgaccggt cgcactgggg cggcgacctg aaaaccatcc 14520 tgcataccaa catgccaaat gtgaacgagt tcatgtttac caataagttt aaggcgcggg 14580 tgatggtgtc gcgcttgcct actaaggaca atcaggtgga gctgaaatac gagtgggtgg 14640 agttcacgct gcccgagggc aactactccg agaccatgac catagacctt atgaacaacg 14700 cgatcgtgga gcactacttg aaagtgggca gacagaacgg ggttctggaa agcgacatcg 14760 gggtaaagtt tgacacccgc aacttcagac tggggtttga ccccgtcact ggtcttgtca 14820 tgcctggggt atatacaaac gaagccttcc atccagacat cattttgctg ccaggatgcg 14880 gggtggactt cacccacagc cgcctgagca acttgttggg catccgcaag cggcaaccct 14940 tccaggaggg ctttaggatc acctacgatg atctggaggg tggtaacatt cccgcactgt 15000 tggatgtgga cgcctaccag gcgagcttga aagatgacac cgaacagggc gggggtggcg 15060 caggcggcag caacagcagt ggcagcggcg cggaagagaa ctccaacgcg gcagccgcgg 15120 caatgcagcc ggtggaggac atgaacgatc atgccattcg cggcgaaacc tttgccacac 15180 gggctgagga gaagcgcgct gaggccgaag cagcggccga agctgccgcc cccgctgcgc 15240 aacccgaggt cgagaagcct cagaagaaac cggtgatcaa acccctgaca gaggacagca 15300 agaaacgcag ttacaaccta ataagcaatg acagcacctt cacccagtac cgcagctggt 15360 accttgcata caactacggc gaccctcaga ccggaatccg ctcatggacc ctgctttgca 15420 ctcctgacgt aacctgcggc tcggagcagg tctactggtc gttgccagac atgatgcaag 15480 accccgtgac cttccgctcc acgcgccaga tcagcaactt tccggtggtg ggcgccgagc 15540 tgttgcccgt gcactccaag agcttctaca acgaccaggc cgtctactcc caactcatcc 15600 gccagtttac ctctctgacc cacgtgttca atcgctttcc cgagaaccag attttggcgc 15660 gcccgccagc ccccaccatc accaccgtca gtgaaaacgt tcctgctctc acagatcacg 15720 ggacgctacc gctgcgcaac agcatcggag gagtccagcg agtgaccatt actgacgcca 15780 gacgccgcac ctgcccctac gtttacaagg ccctgggcat agtctcgccg cgcgtcctat 15840 cgagccgcac tttttgagca agcatgtcca tccttatatc gcccagcaat aacacaggct 15900 ggggcctgcg cttcccaagc aagatgtttg gcggggccaa gaagcgctcc gaccaacacc 15960 cagtgcgcgt gcgcgggcac taccgcgcgc cctggggcgc gcacaaacgc ggccgcactg 16020 ggcgcaccac cgtcgatgac gccatcgacg cggtggtgga ggaggcgcgc aactacacgc 16080 ccacgccgcc accagtgtcc acagtggacg cggccattca gaccgtggtg cgcggagccc 16140 ggcgctatgc taaaatgaag agacggcgga ggcgcgtagc acgtcgccac cgccgccgac 16200 ccggcactgc cgcccaacgc gcggcggcgg ccctgcttaa ccgcgcacgt cgcaccggcc 16260 gacgggcggc catgcgggcc gctcgaaggc tggccgcggg tattgtcact gtgcccccca 16320 ggtccaggcg acgagcggcc gccgcagcag ccgcggccat tagtgctatg actcagggtc 16380 gcaggggcaa cgtgtattgg gtgcgcgact cggttagcgg cctgcgcgtg cccgtgcgca 16440 cccgcccccc gcgcaactag attgcaagaa aaaactactt agactcgtac tgttgtatgt 16500 atccagcggc ggcggcgcgc aacgaagcta tgtccaagcg caaaatcaaa gaagagatgc 16560 tccaggtcat cgcgccggag atctatggcc ccccgaagaa ggaagagcag gattacaagc 16620 cccgaaagct aaagcgggtc aaaaagaaaa agaaagatga tgatgatgaa cttgacgacg 16680 aggtggaact gctgcacgct accgcgccca ggcgacgggt acagtggaaa ggtcgacgcg 16740 taaaacgtgt tttgcgaccc ggcaccaccg tagtctttac gcccggtgag cgctccaccc 16800 gcacctacaa gcgcgtgtat gatgaggtgt acggcgacga ggacctgctt gagcaggcca 16860 acgagcgcct cggggagttt gcctacggaa agcggcataa ggacatgctg gcgttgccgc 16920 tggacgaggg caacccaaca cctagcctaa agcccgtaac actgcagcag gtgctgcccg 16980 cgcttgcacc gtccgaagaa aagcgcggcc taaagcgcga gtctggtgac ttggcaccca 17040 ccgtgcagct gatggtaccc aagcgccagc gactggaaga tgtcttggaa aaaatgaccg 17100 tggaacctgg gctggagccc gaggtccgcg tgcggccaat caagcaggtg gcgccgggac 17160 tgggcgtgca gaccgtggac gttcagatac ccactaccag tagcaccagt attgccaccg 17220 ccacagaggg catggagaca caaacgtccc cggttgcctc agcggtggcg gatgccgcgg 17280 tgcaggcggt cgctgcggcc gcgtccaaga cctctacgga ggtgcaaacg gacccgtgga 17340 tgtttcgcgt ttcagccccc cggcgcccgc gcggttcgag gaagtacggc gccgccagcg 17400 cgctactgcc cgaatatgcc ctacatcctt ccattgcgcc tacccccggc tatcgtggct 17460 acacctaccg ccccagaaga cgagcaacta cccgacgccg aaccaccact ggaacccgcc 17520 gccgccgtcg ccgtcgccag cccgtgctgg ccccgatttc cgtgcgcagg gtggctcgcg 17580 aaggaggcag gaccctggtg ctgccaacag cgcgctacca ccccagcatc gtttaaaagc 17640 cggtctttgt ggttcttgca gatatggccc tcacctgccg cctccgtttc ccggtgccgg 17700 gattccgagg aagaatgcac cgtaggaggg gcatggccgg ccacggcctg acgggcggca 17760 tgcgtcgtgc gcaccaccgg cggcggcgcg cgtcgcaccg tcgcatgcgc ggcggtatcc 17820 tgcccctcct tattccactg atcgccgcgg cgattggcgc cgtgcccgga attgcatccg 17880 tggccttgca ggcgcagaga cactgattaa aaacaagttg catgtggaaa aatcaaaata 17940 aaaagtctgg actctcacgc tcgcttggtc ctgtaactat tttgtagaat ggaagacatc 18000 aactttgcgt ctctggcccc gcgacacggc tcgcgcccgt tcatgggaaa ctggcaagat 18060 atcggcacca gcaatatgag cggtggcgcc ttcagctggg gctcgctgtg gagcggcatt 18120 aaaaatttcg gttccaccgt taagaactat ggcagcaagg cctggaacag cagcacaggc 18180 cagatgctga gggataagtt gaaagagcaa aatttccaac aaaaggtggt agatggcctg 18240 gcctctggca ttagcggggt ggtggacctg gccaaccagg cagtgcaaaa taagattaac 18300 agtaagcttg atccccgccc tcccgtagag gagcctccac cggccgtgga gacagtgtct 18360 ccagaggggc gtggcgaaaa gcgtccgcgc cccgacaggg aagaaactct ggtgacgcaa 18420 atagacgagc ctccctcgta cgaggaggca ctaaagcaag gcctgcccac cacccgtccc 18480 atcgcgccca tggctaccgg agtgctgggc cagcacacac ccgtaacgct ggacctgcct 18540 ccccccgccg acacccagca gaaacctgtg ctgccaggcc cgaccgccgt tgttgtaacc 18600 cgtcctagcc gcgcgtccct gcgccgcgcc gccagcggtc cgcgatcgtt gcggcccgta 18660 gccagtggca actggcaaag cacactgaac agcatcgtgg gtctgggggt gcaatccctg 18720 aagcgccgac gatgcttctg aatagctaac gtgtcgtatg tgtgtcatgt atgcgtccat 18780 gtcgccgcca gaggagctgc tgagccgccg cgcgcccgct ttccaagatg gctacccctt 18840 cgatgatgcc gcagtggtct tacatgcaca tctcgggcca ggacgcctcg gagtacctga 18900 gccccgggct ggtgcagttt gcccgcgcca ccgagacgta cttcagcctg aataacaagt 18960 ttagaaaccc cacggtggcg cctacgcacg acgtgaccac agaccggtcc cagcgtttga 19020 cgctgcggtt catccctgtg gaccgtgagg atactgcgta ctcgtacaag gcgcggttca 19080 ccctagctgt gggtgataac cgtgtgctgg acatggcttc cacgtacttt gacatccgcg 19140 gcgtgctgga caggggccct acttttaagc cctactctgg cactgcctac aacgccctgg 19200 ctcccaaggg tgccccaaat ccttgcgaat gggatgaagc tgctactgct cttgaaataa 19260 acctagaaga agaggacgat gacaacgaag acgaagtaga cgagcaagct gagcagcaaa 19320 aaactcacgt atttgggcag gcgccttatt ctggtataaa tattacaaag gagggtattc 19380 aaataggtgt cgaaggtcaa acacctaaat atgccgataa aacatttcaa cctgaacctc 19440 aaataggaga atctcagtgg tacgaaactg aaattaatca tgcagctggg agagtcctta 19500 aaaagactac cccaatgaaa ccatgttacg gttcatatgc aaaacccaca aatgaaaatg 19560 gagggcaagg cattcttgta aagcaacaaa atggaaagct agaaagtcaa gtggaaatgc 19620 aatttttctc aactactgag gcgaccgcag gcaatggtga taacttgact cctaaagtgg 19680 tattgtacag tgaagatgta gatatagaaa ccccagacac tcatatttct tacatgccca 19740 ctattaagga aggtaactca cgagaactaa tgggccaaca atctatgccc aacaggccta 19800 attacattgc ttttagggac aattttattg gtctaatgta ttacaacagc acgggtaata 19860 tgggtgttct ggcgggccaa gcatcgcagt tgaatgctgt tgtagatttg caagacagaa 19920 acacagagct ttcataccag cttttgcttg attccattgg tgatagaacc aggtactttt 19980 ctatgtggaa tcaggctgtt gacagctatg atccagatgt tagaattatt gaaaatcatg 20040 gaactgaaga tgaacttcca aattactgct ttccactggg aggtgtgatt aatacagaga 20100 ctcttaccaa ggtaaaacct aaaacaggtc aggaaaatgg atgggaaaaa gatgctacag 20160 aattttcaga taaaaatcaa ataagagttg gaaataattt tgccatggaa atcaatctaa 20220 atgccaacct gtggagaaat ttcctgtact ccaacatagc gctgtatttg cccgacaagc 20280 taaagtacag tccttccaac gtaaaaattt ctgataaccc aaacacctac gactacatga 20340 acaagcgagt ggtggctccc gggttagtgg actgctacat taaccttgga gcacgctggt 20400 cccttgacta tatggacaac gtcaacccat ttaaccacca ccgcaatgct ggcctgcgct 20460 accgctcaat gttgctgggc aatggtcgct atgtgccctt ccacatccag gtgcctcaga 20520 agttctttgc cattaaaaac ctccttctcc tgccgggctc atacacctac gagtggaact 20580 tcaggaagga tgttaacatg gttctgcaga gctccctagg aaatgaccta agggttgacg 20640 gagccagcat taagtttgat agcatttgcc tttacgccac cttcttcccc atggcccaca 20700 acaccgcctc cacgcttgag gccatgctta gaaacgacac caacgaccag tcctttaacg 20760 actatctctc cgccgccaac atgctctacc ctatacccgc caacgctacc aacgtgccca 20820 tatccatccc ctcccgcaac tgggcggctt tccgcggctg ggccttcacg cgccttaaga 20880 ctaaggaaac cccatcactg ggctcgggct acgaccctta ttacacctac tctggctcta 20940 taccctacct agatggaacc ttttacctca accacacctt taagaaggtg gccattacct 21000 ttgactcttc tgtcagctgg cctggcaatg accgcctgct tacccccaac gagtttgaaa 21060 ttaagcgctc agttgacggg gagggttaca acgttgccca gtgtaacatg accaaagact 21120 ggttcctggt acaaatgcta gctaactaca acattggcta ccagggcttc tatatcccag 21180 agagctacaa ggaccgcatg tactccttct ttagaaactt ccagcccatg agccgtcagg 21240 tggtggatga tactaaatac aaggactacc aacaggtggg catcctacac caacacaaca 21300 actctggatt tgttggctac cttgccccca ccatgcgcga aggacaggcc taccctgcta 21360 acttccccta tccgcttata ggcaagaccg cagttgacag cattacccag aaaaagtttc 21420 tttgcgatcg caccctttgg cgcatcccat tctccagtaa ctttatgtcc atgggcgcac 21480 tcacagacct gggccaaaac cttctctacg ccaactccgc ccacgcgcta gacatgactt 21540 ttgaggtgga tcccatggac gagcccaccc ttctttatgt tttgtttgaa gtctttgacg 21600 tggtccgtgt gcaccggccg caccgcggcg tcatcgaaac cgtgtacctg cgcacgccct 21660 tctcggccgg caacgccaca acataaagaa gcaagcaaca tcaacaacag ctgccgccat 21720 gggctccagt gagcaggaac tgaaagccat tgtcaaagat cttggttgtg ggccatattt 21780 tttgggcacc tatgacaagc gctttccagg ctttgtttct ccacacaagc tcgcctgcgc 21840 catagtcaat acggccggtc gcgagactgg gggcgtacac tggatggcct ttgcctggaa 21900 cccgcactca aaaacatgct acctctttga gccctttggc ttttctgacc agcgactcaa 21960 gcaggtttac cagtttgagt acgagtcact cctgcgccgt agcgccattg cttcttcccc 22020 cgaccgctgt ataacgctgg aaaagtccac ccaaagcgta caggggccca actcggccgc 22080 ctgtggacta ttctgctgca tgtttctcca cgcctttgcc aactggcccc aaactcccat 22140 ggatcacaac cccaccatga accttattac cggggtaccc aactccatgc tcaacagtcc 22200 ccaggtacag cccaccctgc gtcgcaacca ggaacagctc tacagcttcc tggagcgcca 22260 ctcgccctac ttccgcagcc acagtgcgca gattaggagc gccacttctt tttgtcactt 22320 gaaaaacatg taaaaataat gtactagaga cactttcaat aaaggcaaat gcttttattt 22380 gtacactctc gggtgattat ttacccccac ccttgccgtc tgcgccgttt aaaaatcaaa 22440 ggggttctgc cgcgcatcgc tatgcgccac tggcagggac acgttgcgat actggtgttt 22500 agtgctccac ttaaactcag gcacaaccat ccgcggcagc tcggtgaagt tttcactcca 22560 caggctgcgc accatcacca acgcgtttag caggtcgggc gccgatatct tgaagtcgca 22620 gttggggcct ccgccctgcg cgcgcgagtt gcgatacaca gggttgcagc actggaacac 22680 tatcagcgcc gggtggtgca cgctggccag cacgctcttg tcggagatca gatccgcgtc 22740 caggtcctcc gcgttgctca gggcgaacgg agtcaacttt ggtagctgcc ttcccaaaaa 22800 gggcgcgtgc ccaggctttg agttgcactc gcaccgtagt ggcatcaaaa ggtgaccgtg 22860 cccggtctgg gcgttaggat acagcgcctg cataaaagcc ttgatctgct taaaagccac 22920 ctgagccttt gcgccttcag agaagaacat gccgcaagac ttgccggaaa actgattggc 22980 cggacaggcc gcgtcgtgca cgcagcacct tgcgtcggtg ttggagatct gcaccacatt 23040 tcggccccac cggttcttca cgatcttggc cttgctagac tgctccttca gcgcgcgctg 23100 cccgttttcg ctcgtcacat ccatttcaat cacgtgctcc ttatttatca taatgcttcc 23160 gtgtagacac ttaagctcgc cttcgatctc agcgcagcgg tgcagccaca acgcgcagcc 23220 cgtgggctcg tgatgcttgt aggtcacctc tgcaaacgac tgcaggtacg cctgcaggaa 23280 tcgccccatc atcgtcacaa aggtcttgtt gctggtgaag gtcagctgca acccgcggtg 23340 ctcctcgttc agccaggtct tgcatacggc cgccagagct tccacttggt caggcagtag 23400 tttgaagttc gcctttagat cgttatccac gtggtacttg tccatcagcg cgcgcgcagc 23460 ctccatgccc ttctcccacg cagacacgat cggcacactc agcgggttca tcaccgtaat 23520 ttcactttcc gcttcgctgg gctcttcctc ttcctcttgc gtccgcatac cacgcgccac 23580 tgggtcgtct tcattcagcc gccgcactgt gcgcttacct cctttgccat gcttgattag 23640 caccggtggg ttgctgaaac ccaccatttg tagcgccaca tcttctcttt cttcctcgct 23700 gtccacgatt acctctggtg atggcgggcg ctcgggcttg ggagaagggc gcttcttttt 23760 cttcttgggc gcaatggcca aatccgccgc cgaggtcgat ggccgcgggc tgggtgtgcg 23820 cggcaccagc gcgtcttgtg atgagtcttc ctcgtcctcg gactcgatac gccgcctcat 23880 ccgctttttt gggggcgccc ggggaggcgg cggcgacggg gacggggacg acacgtcctc 23940 catggttggg ggacgtcgcg ccgcaccgcg tccgcgctcg ggggtggttt cgcgctgctc 24000 ctcttcccga ctggccattt ccttctccta taggcagaaa aagatcatgg agtcagtcga 24060 gaagaaggac agcctaaccg ccccctctga gttcgccacc accgcctcca ccgatgccgc 24120 caacgcgcct accaccttcc ccgtcgaggc acccccgctt gaggaggagg aagtgattat 24180 cgagcaggac ccaggttttg taagcgaaga cgacgaggac cgctcagtac caacagagga 24240 taaaaagcaa gaccaggaca acgcagaggc aaacgaggaa caagtcgggc ggggggacga 24300 aaggcatggc gactacctag atgtgggaga cgacgtgctg ttgaagcatc tgcagcgcca 24360 gtgcgccatt atctgcgacg cgttgcaaga gcgcagcgat gtgcccctcg ccatagcgga 24420 tgtcagcctt gcctacgaac gccacctatt ctcaccgcgc gtacccccca aacgccaaga 24480 aaacggcaca tgcgagccca acccgcgcct caacttctac cccgtatttg ccgtgccaga 24540 ggtgcttgcc acctatcaca tctttttcca aaactgcaag atacccctat cctgccgtgc 24600 caaccgcagc cgagcggaca agcagctggc cttgcggcag ggcgctgtca tacctgatat 24660 cgcctcgctc aacgaagtgc caaaaatctt tgagggtctt ggacgcgacg agaagcgcgc 24720 ggcaaacgct ctgcaacagg aaaacagcga aaatgaaagt cactctggag tgttggtgga 24780 actcgagggt gacaacgcgc gcctagccgt actaaaacgc agcatcgagg tcacccactt 24840 tgcctacccg gcacttaacc taccccccaa ggtcatgagc acagtcatga gtgagctgat 24900 cgtgcgccgt gcgcagcccc tggagaggga tgcaaatttg caagaacaaa cagaggaggg 24960 cctacccgca gttggcgacg agcagctagc gcgctggctt caaacgcgcg agcctgccga 25020 cttggaggag cgacgcaaac taatgatggc cgcagtgctc gttaccgtgg agcttgagtg 25080 catgcagcgg ttctttgctg acccggagat gcagcgcaag ctagaggaaa cattgcacta 25140 cacctttcga cagggctacg tacgccaggc ctgcaagatc tccaacgtgg agctctgcaa 25200 cctggtctcc taccttggaa ttttgcacga aaaccgcctt gggcaaaacg tgcttcattc 25260 cacgctcaag ggcgaggcgc gccgcgacta cgtccgcgac tgcgtttact tatttctatg 25320 ctacacctgg cagacggcca tgggcgtttg gcagcagtgc ttggaggagt gcaacctcaa 25380 ggagctgcag aaactgctaa agcaaaactt gaaggaccta tggacggcct tcaacgagcg 25440 ctccgtggcc gcgcacctgg cggacatcat tttccccgaa cgcctgctta aaaccctgca 25500 acagggtctg ccagacttca ccagtcaaag catgttgcag aactttagga actttatcct 25560 agagcgctca ggaatcttgc ccgccacctg ctgtgcactt cctagcgact ttgtgcccat 25620 taagtaccgc gaatgccctc cgccgctttg gggccactgc taccttctgc agctagccaa 25680 ctaccttgcc taccactctg acataatgga agacgtgagc ggtgacggtc tactggagtg 25740 tcactgtcgc tgcaacctat gcaccccgca ccgctccctg gtttgcaatt cgcagctgct 25800 taacgaaagt caaattatcg gtacctttga gctgcagggt ccctcgcctg acgaaaagtc 25860 cgcggctccg gggttgaaac tcactccggg gctgtggacg tcggcttacc ttcgcaaatt 25920 tgtacctgag gactaccacg cccacgagat taggttctac gaagaccaat cccgcccgcc 25980 aaatgcggag cttaccgcct gcgtcattac ccagggccac attcttggcc aattgcaagc 26040 catcaacaaa gcccgccaag agtttctgct acgaaaggga cggggggttt acttggaccc 26100 ccagtccggc gaggagctca acccaatccc cccgccgccg cagccctatc agcagcagcc 26160 gcgggccctt gcttcccagg atggcaccca aaaagaagct gcagctgccg ccgccaccca 26220 cggacgagga ggaatactgg gacagtcagg cagaggaggt tttggacgag gaggaggagg 26280 acatgatgga agactgggag agcctagacg aggaagcttc cgaggtcgaa gaggtgtcag 26340 acgaaacacc gtcaccctcg gtcgcattcc cctcgccggc gccccagaaa tcggcaaccg 26400 gttccagcat ggctacaacc tccgctcctc aggcgccgcc ggcactgccc gttcgccgac 26460 ccaaccgtag atgggacacc actggaacca gggccggtaa gtccaagcag ccgccgccgt 26520 tagcccaaga gcaacaacag cgccaaggct accgctcatg gcgcgggcac aagaacgcca 26580 tagttgcttg cttgcaagac tgtgggggca acatctcctt cgcccgccgc tttcttctct 26640 accatcacgg cgtggccttc ccccgtaaca tcctgcatta ctaccgtcat ctctacagcc 26700 catactgcac cggcggcagc ggcagcggca gcaacagcag cggccacaca gaagcaaagg 26760 cgaccggata gcaagactct gacaaagccc aagaaatcca cagcggcggc agcagcagga 26820 ggaggagcgc tgcgtctggc gcccaacgaa cccgtatcga cccgcgagct tagaaacagg 26880 atttttccca ctctgtatgc tatatttcaa cagagcaggg gccaagaaca agagctgaaa 26940 ataaaaaaca ggtctctgcg atccctcacc cgcagctgcc tgtatcacaa aagcgaagat 27000 cagcttcggc gcacgctgga agacgcggag gctctcttca gtaaatactg cgcgctgact 27060 cttaaggact agtttcgcgc cctttctcaa atttaagcgc gaaaactacg tcatctccag 27120 cggccacacc cggcgccagc acctgtcgtc agcgccattt atgagcaagg aaattcccac 27180 gccctacatg tggagttacc agccacaaat gggacttgcg gctggagctg cccaagacta 27240 ctcaacccga ataaactaca tgagcgcggg accccacatg atatcccggg tcaacggaat 27300 acgcgcccac cgaaaccgaa ttctcctgga acaggcggct attaccacca cacctcgtaa 27360 taaccttaat ccccgtagtt ggcccgctgc cctggtgtac caggaaagtc ccgctcccac 27420 cactgtggta cttcccagag acgcccaggc cgaagttcag atgactaact caggggcgca 27480 gcttgcgggc ggctttcgtc acagggtgcg gtcgcccggg cagggtataa ctcacctgac 27540 aatcagaggg cgaggtattc agctcaacga cgagtcggtg agctcctcgc ttggtctccg 27600 tccggacggg acatttcaga tcggcggcgc cggccgctct tcattcacgc ctcgtcaggc 27660 aatcctaact ctgcagacct cgtcctctga gccgcgctct ggaggcattg gaactctgca 27720 atttattgag gagtttgtgc catcggtcta ctttaacccc ttctcgggac ctcccggcca 27780 ctatccggat caatttattc ctaactttga cgcggtaaag gactcggcgg acggctacga 27840 ctgaatgtta agtggagagg cagagcaact gcgcctgaaa cacctggtcc actgtcgccg 27900 ccacaagtgc tttgcccgcg actccggtga gttttgctac tttgaattgc ccgaggatca 27960 tatcgagggc ccggcgcacg gcgtccggct taccgcccag ggagagcttg cccgtagcct 28020 gattcgggag tttacccagc gccccctgct agttgagcgg gacaggggac cctgtgttct 28080 cactgtgatt tgcaactgtc ctaaccctgg attacatcaa gatctttgtt gccatctctg 28140 tgctgagtat aataaataca gaaattaaaa tatactgggg ctcctatcgc catcctgtaa 28200 acgccaccgt cttcacccgc ccaagcaaac caaggcgaac cttacctggt acttttaaca 28260 tctctccctc tgtgatttac aacagtttca acccagacgg agtgagtcta cgagagaacc 28320 tctccgagct cagctactcc atcagaaaaa acaccaccct ccttacctgc cgggaacgta 28380 cgagtgcgtc accggccgct gcaccacacc taccgcctga ccgtaaacca gactttttcc 28440 ggacagacct caataactct gtttaccaga acaggaggtg agcttagaaa acccttaggg 28500 tattaggcca aaggcgcagc tactgtgggg tttatgaaca attcaagcaa ctctacgggc 28560 tattctaatt caggtttctc tagaatcggg gttggggtta ttctctgtct tgtgattctc 28620 tttattctta tactaacgct tctctgccta aggctcgccg cctgctgtgt gcacatttgc 28680 atttattgtc agctttttaa acgctggggt cgccacccaa gatgattagg tacataatcc 28740 taggtttact cacccttgcg tcagcccacg gtaccaccca aaaggtggat tttaaggagc 28800 cagcctgtaa tgttacattc gcagctgaag ctaatgagtg caccactctt ataaaatgca 28860 ccacagaaca tgaaaagctg cttattcgcc acaaaaacaa aattggcaag tatgctgttt 28920 atgctatttg gcagccaggt gacactacag agtataatgt tacagttttc cagggtaaaa 28980 gtcataaaac ttttatgtat acttttccat tttatgaaat gtgcgacatt accatgtaca 29040 tgagcaaaca gtataagttg tggcccccac aaaattgtgt ggaaaacact ggcactttct 29100 gctgcactgc tatgctaatt acagtgctcg ctttggtctg taccctactc tatattaaat 29160 acaaaagcag acgcagcttt attgaggaaa agaaaatgcc ttaatttact aagttacaaa 29220 gctaatgtca ccactaactg ctttactcgc tgcttgcaaa acaaattcaa aaagttagca 29280 ttataattag aataggattt aaaccccccg gtcatttcct gctcaatacc attcccctga 29340 acaattgact ctatgtggga tatgctccag cgctacaacc ttgaagtcag gcttcctgga 29400 tgtcagcatc tgactttggc cagcacctgt cccgcggatt tgttccagtc caactacagc 29460 gacccaccct aacagagatg accaacacaa ccaacgcggc cgccgctacc ggacttacat 29520 ctaccacaaa tacaccccaa gtttctgcct ttgtcaataa ctgggataac ttgggcatgt 29580 ggtggttctc catagcgctt atgtttgtat gccttattat tatgtggctc atctgctgcc 29640 taaagcgcaa acgcgcccga ccacccatct atagtcccat cattgtgcta cacccaaaca 29700 atgatggaat ccatagattg gacggactga aacacatgtt cttttctctt acagtatgat 29760 taaatgagac atgattcctc gagtttttat attactgacc cttgttgcgc ttttttgtgc 29820 gtgctccaca ttggctgcgg tttctcacat cgaagtagac tgcattccag ccttcacagt 29880 ctatttgctt tacggatttg tcaccctcac gctcatctgc agcctcatca ctgtggtcat 29940 cgcctttatc cagtgcattg actgggtctg tgtgcgcttt gcatatctca gacaccatcc 30000 ccagtacagg gacaggacta tagctgagct tcttagaatt ctttaattat gaaatttact 30060 gtgacttttc tgctgattat ttgcacccta tctgcgtttt gttccccgac ctccaagcct 30120 caaagacata tatcatgcag attcactcgt atatggaata ttccaagttg ctacaatgaa 30180 aaaagcgatc tttccgaagc ctggttatat gcaatcatct ctgttatggt gttctgcagt 30240 accatcttag ccctagctat atatccctac cttgacattg gctggaacgc aatagatgcc 30300 atgaaccacc caactttccc cgcgcccgct atgcttccac tgcaacaagt tgttgccggc 30360 ggctttgtcc cagccaatca gcctcgccca ccttctccca cccccactga aatcagctac 30420 tttaatctaa caggaggaga tgactgacac cctagatcta gaaatggacg gaattattac 30480 agagcagcgc ctgctagaaa gacgcagggc agcggccgag caacagcgca tgaatcaaga 30540 gctccaagac atggttaact tgcaccagtg caaaaggggt atcttttgtc tggtaaagca 30600 ggccaaagtc acctacgaca gtaataccac cggacaccgc cttagctaca agttgccaac 30660 caagcgtcag aaattggtgg tcatggtggg agaaaagccc attaccataa ctcagcactc 30720 ggtagaaacc gaaggctgca ttcactcacc ttgtcaagga cctgaggatc tctgcaccct 30780 tattaagacc ctgtgcggtc tcaaagatct tattcccttt aactaataaa aaaaaataat 30840 aaagcatcac ttacttaaaa tcagttagca aatttctgtc cagtttattc agcagcacct 30900 ccttgccctc ctcccagctc tggtattgca gcttcctcct ggctgcaaac tttctccaca 30960 atctaaatgg aatgtcagtt tcctcctgtt cctgtccatc cgcacccact atcttcatgt 31020 tgttgcagat gaagcgcgca agaccgtctg aagatacctt caaccccgtg tatccatatg 31080 acacggaaac cggtcctcca actgtgcctt ttcttactcc tccctttgta tcccccaatg 31140 ggtttcaaga gagtccccct ggggtactct ctttgcgcct atccgaacct ctagttacct 31200 ccaatggcat gcttgcgctc aaaatgggca acggcctctc tctggacgag gccggcaacc 31260 ttacctccca aaatgtaacc actgtgagcc cacctctcaa aaaaaccaag tcaaacataa 31320 acctggaaat atctgcaccc ctcacagtta cctcagaagc cctaactgtg gctgccgccg 31380 cacctctaat ggtcgcgggc aacacactca ccatgcaatc acaggccccg ctaaccgtgc 31440 acgactccaa acttagcatt gccacccaag gacccctcac agtgtcagaa ggaaagctag 31500 ccctgcaaac atcaggcccc ctcaccacca ccgatagcag tacccttact atcactgcct 31560 caccccctct aactactgcc actggtagct tgggcattga cttgaaagag cccatttata 31620 cacaaaatgg aaaactagga ctaaagtacg gggctccttt gcatgtaaca gacgacctaa 31680 acactttgac cgtagcaact ggtccaggtg tgactattaa taatacttcc ttgcaaacta 31740 aagttactgg agccttgggt tttgattcac aaggcaatat gcaacttaat gtagcaggag 31800 gactaaggat tgattctcaa aacagacgcc ttatacttga tgttagttat ccgtttgatg 31860 ctcaaaacca actaaatcta agactaggac agggccctct ttttataaac tcagcccaca 31920 acttggatat taactacaac aaaggccttt acttgtttac agcttcaaac aattccaaaa 31980 agcttgaggt taacctaagc actgccaagg ggttgatgtt tgacgctaca gccatagcca 32040 ttaatgcagg agatgggctt gaatttggtt cacctaatgc accaaacaca aatcccctca 32100 aaacaaaaat tggccatggc ctagaatttg attcaaacaa ggctatggtt cctaaactag 32160 gaactggcct tagttttgac agcacaggtg ccattacagt aggaaacaaa aataatgata 32220 agctaacttt gtggaccaca ccagctccat ctcctaactg tagactaaat gcagagaaag 32280 atgctaaact cactttggtc ttaacaaaat gtggcagtca aatacttgct acagtttcag 32340 ttttggctgt taaaggcagt ttggctccaa tatctggaac agttcaaagt gctcatctta 32400 ttataagatt tgacgaaaat ggagtgctac taaacaattc cttcctggac ccagaatatt 32460 ggaactttag aaatggagat cttactgaag gcacagccta tacaaacgct gttggattta 32520 tgcctaacct atcagcttat ccaaaatctc acggtaaaac tgccaaaagt aacattgtca 32580 gtcaagttta cttaaacgga gacaaaacta aacctgtaac actaaccatt acactaaacg 32640 gtacacagga aacaggagac acaacttgcg actgcagagg cgactgcttc tgcccaagtg 32700 catactctat gtcattttca tgggactggt ctggccacaa ctacattaat gaaatatttg 32760 ccacatcctc ttacactttt tcatacattg cccaagaata aagaatcgtt tgtgttatgt 32820 ttcaacgtgt ttatttttca attgcagaaa atttcgaatc atttttcatt cagtagtata 32880 gccccaccac cacatagctt atacagatca ccgtacctta atcaaaccta catgggggta 32940 gagtcataat cgtgcatcag gatagggcgg tggtgctgca gcagcgcgcg aataaactgc 33000 tgccgccgcc gctccgtcct gcaggaatac aacatggcag tggtctcctc agcgatgatt 33060 cgcaccgccc gcagcataag gcgccttgtc ctccgggcac agcagcgcac cctgatctca 33120 cttaaatcag cacagtaact gcagcacagc accacaatat tgttcaaaat cccacagtgc 33180 aaggcgctgt atccaaagct catggcgggg accacagaac ccacgtggcc atcataccac 33240 aagcgcaggt agattaagtg gcgacccctc ataaacacgc tggacataaa cattacctct 33300 tttggcatgt tgtaattcac cacctcccgg taccatataa acctctgatt aaacatggcg 33360 ccatccacca ccatcctaaa ccagctggcc aaaacctgcc cgccggctat acactgcagg 33420 gaaccgggac tggaacaatg acagtggaga gcccaggact cgtaaccatg gatcatcatg 33480 ctcgtcatga tatcaatgtt ggcacaacac aggcacacgt gcatacactt cctcaggatt 33540 acaagctcct cccgcgttag aaccatatcc cagggaacaa cccattcctg aatcagcgta 33600 aatcccacac tgcagggaag acctcgcacg taactcacgt tgtgcattgt caaagtgtta 33660 cattcgggca gcagcggatg atcctccagt atggtagcgc gggtttctgt ctcaaaagga 33720 ggtagacgat ccctactgta cggagtgcgc cgagacaacc gagatcgtgt tggtcgtagt 33780 gtcatgccaa atggaacgcc ggacgtagtc atatttcctg aagcaaaacc aggtgcgggc 33840 gtgacaaaca gatctgcgtc tccggtctcg ccgcttagat cgctctgtgt agtagttgta 33900 gtatatccac tctctcaaag catccaggcg ccccctggct tcgggttcta tgtaaactcc 33960 ttcatgcgcc gctgccctga taacatccac caccgcagaa taagccacac ccagccaacc 34020 tacacattcg ttctgcgagt cacacacggg aggagcggga agagctggaa gaaccatgtt 34080 ttttttttta ttccaaaaga ttatccaaaa cctcaaaatg aagatctatt aagtgaacgc 34140 gctcccctcc ggtggcgtgg tcaaactcta cagccaaaga acagataatg gcatttgtaa 34200 gatgttgcac aatggcttcc aaaaggcaaa cggccctcac gtccaagtgg acgtaaaggc 34260 taaacccttc agggtgaatc tcctctataa acattccagc accttcaacc atgcccaaat 34320 aattctcatc tcgccacctt ctcaatatat ctctaagcaa atcccgaata ttaagtccgg 34380 ccattgtaaa aatctgctcc agagcgccct ccaccttcag cctcaagcag cgaatcatga 34440 ttgcaaaaat tcaggttcct cacagacctg tataagattc aaaagcggaa cattaacaaa 34500 aataccgcga tcccgtaggt cccttcgcag ggccagctga acataatcgt gcaggtctgc 34560 acggaccagc gcggccactt ccccgccagg aaccatgaca aaagaaccca cactgattat 34620 gacacgcata ctcggagcta tgctaaccag cgtagccccg atgtaagctt gttgcatggg 34680 cggcgatata aaatgcaagg tgctgctcaa aaaatcaggc aaagcctcgc gcaaaaaaga 34740 aagcacatcg tagtcatgct catgcagata aaggcaggta agctccggaa ccaccacaga 34800 aaaagacacc atttttctct caaacatgtc tgcgggtttc tgcataaaca caaaataaaa 34860 taacaaaaaa acatttaaac attagaagcc tgtcttacaa caggaaaaac aacccttata 34920 agcataagac ggactacggc catgccggcg tgaccgtaaa aaaactggtc accgtgatta 34980 aaaagcacca ccgacagctc ctcggtcatg tccggagtca taatgtaaga ctcggtaaac 35040 acatcaggtt gattcacatc ggtcagtgct aaaaagcgac cgaaatagcc cgggggaata 35100 catacccgca ggcgtagaga caacattaca gcccccatag gaggtataac aaaattaata 35160 ggagagaaaa acacataaac acctgaaaaa ccctcctgcc taggcaaaat agcaccctcc 35220 cgctccagaa caacatacag cgcttccaca gcggcagcca taacagtcag ccttaccagt 35280 aaaaaagaaa acctattaaa aaaacaccac tcgacacggc accagctcaa tcagtcacag 35340 tgtaaaaaag ggccaagtgc agagcgagta tatataggac taaaaaatga cgtaacggtt 35400 aaagtccaca aaaaacaccc agaaaaccgc acgcgaacct acgcccagaa acgaaagcca 35460 aaaaacccac aacttcctca aatcgtcact tccgttttcc cacgttacgt cacttcccat 35520 tttaagaaaa ctacaattcc caacacatac aagttactcc gccctaaaac ctacgtcacc 35580 cgccccgttc ccacgccccg cgccacgtca caaactccac cccctcatta tcatattggc 35640 ttcaatccaa aataaggtat attattgatg atg 35673 <210> 88 <211> 36674 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO205) <400> 88 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc 600 catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg 660 cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct 720 gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg 780 ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt 840 ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa 900 gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga 960 cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat 1020 ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga 1080 cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt 1140 gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga 1200 gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat 1260 ggacgagctg tacaagggaa gtggacggga gggaatgaga catattatct gccacggagg 1320 tgttattacc gaagaaatgg ccgccagtct tttggaccag ctgatcgaag aggtactggc 1380 tgataatctt ccacctccta gccattttga accacctacc cttcacgaac tgtatgattt 1440 agacgtgacg gcccccgaag atcccaacga ggaggcggtt tcgcagattt ttcccgactc 1500 tgtaatgttg gcggtgcagg aagggattga cttactcact tttccgccgg cgcccggttc 1560 tccggagccg cctcaccttt cccggcagcc cgagcagccg gagcagagag ccttgggtcc 1620 ggtttctatg ccaaaccttg taccggaggt gatcgatctt acctgccacg aggctggctt 1680 tccacccagt gacgacgagg atgaagaggg tgaggagttt gtgttagatt atgtggagca 1740 ccccgggcac ggttgcaggt cttgtcatta tcaccggagg aatacggggg acccagatat 1800 tatgtgttcg ctttgctata tgaggacctg tggcatgttt gtctacagta agtgaaaatt 1860 atgggcagtg ggtgatagag tggtgggttt ggtgtggtaa tttttttttt aatttttaca 1920 gttttgtggt ttaaagaatt ttgtattgtg atttttttaa aaggtcctgt gtctgaacct 1980 gagcctgagc ccgagccaga accggagcct gcaagaccta cccgccgtcc taaaatggcg 2040 cctgctatcc tgagacgccc gacatcacct gtgtctagag aatgcaatag tagtacggat 2100 agctgtgact ccggtccttc taacacacct cctgagatac acccggtggt cccgctgtgc 2160 cccattaaac cagttgccgt gagagttggt gggcgtcgcc aggctgtgga atgtatcgag 2220 gacttgctta acgagcctgg gcaacctttg gacttgagct gtaaacgccc caggccataa 2280 ggtgtaaacc tgtgattgcg tgtgtggtta acgcctttgt ttgctgaatg agttgatgta 2340 agtttaataa agggtgagat aatgtttaac ttgcatggcg tgttaaatgg ggcggggctt 2400 aaagggtata taatgcgccg tgggctaatc ttggttacat ctgacctcat ggaggcttgg 2460 gagtgtttgg aagatttttc tgctgtgcgt aacttgctgg aacagagctc taacagtacc 2520 tcttggtttt ggaggtttct gtggggctca tcccaggcaa agttagtctg cagaattaag 2580 gaggattaca agtgggaatt tgaagagctt ttgaaatcct gtggtgagct gtttgattct 2640 ttgaatctgg gtcaccaggc gcttttccaa gagaaggtca tcaagacttt ggatttttcc 2700 acaccggggc gcgctgcggc tgctgttgct tttttgagtt ttataaagga taaatggagc 2760 gaagaaaccc atctgagcgg ggggtacctg ctggattttc tggccatgca tctgtggaga 2820 gcggttgtga gacacaagaa tcgcctgcta ctgttgtctt ccgtccgccc ggcgataata 2880 ccgacggagg agcagcagca gcagcaggag gaagccaggc ggcggcggca ggagcagagc 2940 ccatggaacc cgagagccgg cctggaccct cgggaatgaa tgttgtacag gtggctgaac 3000 tgtatccaga actgagacgc attttgacaa ttacagagga tgggcagggg ctaaaggggg 3060 taaagaggga gcggggggct tgtgaggcta cagaggaggc taggaatcta gcttttagct 3120 taatgaccag acaccgtcct gagtgtatta cttttcaaca gatcaaggat aattgcgcta 3180 atgagcttga tctgctggcg cagaagtatt ccatagagca gctgaccact tactggctgc 3240 agccagggga tgattttgag gaggctatta gggtatatgc aaaggtggca cttaggccag 3300 attgcaagta caagatcagc aaacttgtaa atatcaggaa ttgttgctac atttctggga 3360 acggggccga ggtggagata gatacggagg atagggtggc ctttagatgt agcatgataa 3420 atatgtggcc gggggtgctt ggcatggacg gggtggttat tatgaatgta aggtttactg 3480 gccccaattt tagcggtacg gttttcctgg ccaataccaa ccttatccta cacggtgtaa 3540 gcttctatgg gtttaacaat acctgtgtgg aagcctggac cgatgtaagg gttcggggct 3600 gtgcctttta ctgctgctgg aagggggtgg tgtgtcgccc caaaagcagg gcttcaatta 3660 agaaatgcct ctttgaaagg tgtaccttgg gtatcctgtc tgagggtaac tccagggtgc 3720 gccacaatgt ggcctccgac tgtggttgct tcatgctagt gaaaagcgtg gctgtgatta 3780 agcataacat ggtatgtggc aactgcgagg acagggcctc tcagatgctg acctgctcgg 3840 acggcaactg tcacctgctg aagaccattc acgtagccag ccactctcgc aaggcctggc 3900 cagtgtttga gcataacata ctgacccgct gttccttgca tttgggtaac aggagggggg 3960 tgttcctacc ttaccaatgc aatttgagtc acactaagat attgcttgag cccgagagca 4020 tgtccaaggt gaacctgaac ggggtgtttg acatgaccat gaagatctgg aaggtgctga 4080 ggtacgatga gacccgcacc aggtgcagac cctgcgagtg tggcggtaaa catattagga 4140 accagcctgt gatgctggat gtgaccgagg agctgaggcc cgatcacttg gtgctggcct 4200 gcacccgcgc tgagtttggc tctagcgatg aagatacaga ttgaggtact gaaatgtgtg 4260 ggcgtggctt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct 4320 gttttgcagc agccgccgcc gcccaacttt tctatacaaa gttgtaatga gcaccaactc 4380 gtttgatgga agcattgtga gctcatattt gacaacgcgc atgcccccat gggccggggt 4440 gcgtcagaat gtgatgggct ccagcattga tggtcgcccc gtcctgcccg caaactctac 4500 taccttgacc tacgagaccg tgtctggaac gccgttggag actgcagcct ccgccgccgc 4560 ttcagccgct gcagccaccg cccgcgggat tgtgactgac tttgctttcc tgagcccgct 4620 tgcaagcagt gcagcttccc gttcatccgc ccgcgatgac aagttgacgg ctcttttggc 4680 acaattggat tctttgaccc gggaacttaa tgtcgtttct cagcagctgt tggatctgcg 4740 ccagcaggtt tctgccctga aggcttcctc ccctcccaat gcggtttaaa acataaataa 4800 aaaaccagac tctgtttgga tttggatcaa gcataagtgt cttgctgtct ttatttaggg 4860 gttttgcgcg cgcggtaggc ccgggaccag cggtctcggt cgttgagggt cctgtgtatt 4920 ttttccagga cgtggtaaag gtgactctgg atgttcagat acatgggcat aagcccgtct 4980 ctggggtgga ggtagcacca ctgcagagct tcatgctgcg gggtggtgtt gtagatgatc 5040 cagtcgtagc aggagcgctg ggcgtggtgc ctaaaaatgt ctttcagtag caagctgatt 5100 gccaggggca ggcccttggt gtaagtgttt acaaagcggt taagctggga tgggtgcata 5160 cgtggggata tgagatgcat cttggactgt atttttaggt tggctatgtt cccagccata 5220 tccctccggg gattcatgtt gtgcagaacc accagcacag tgtatccggt gcacttggga 5280 aatttgtcat gtagcttaga aggaaatgcg tggaagaact tggagacgcc cttgtgacct 5340 ccaagatttt ccatgcattc gtccataatg atggcaatgg gcccacgggc ggcggcctgg 5400 gcgaagatat ttctgggatc actaacgtca tagttgtgtt ccaggatgag atcgtcatag 5460 gccattttta caaagcgcgg gcggagggtg ccagactgcg gtataatggt tccatccggc 5520 ccaggggcgt agttaccctc acagatttgc atttcccacg ctttgagttc agatgggggg 5580 atcatgtcta cctgcggggc gatgaagaaa acggtttccg gggtagggga gatcagctgg 5640 gaagaaagca ggttcctgag cagctgcgac ttaccgcagc cggtgggccc gtaaatcaca 5700 cctattaccg ggtgcaactg gtagttaaga gagctgcagc tgccgtcatc cctgagcagg 5760 ggggccactt cgttaagcat gtccctgact cgcatgtttt ccctgaccaa atccgccaga 5820 aggcgctcgc cgcccagcga tagcagttct tgcaaggaag caaagttttt caacggtttg 5880 agaccgtccg ccgtaggcat gcttttgagc gtttgaccaa gcagttccag gcggtcccac 5940 agctcggtca cctgctctac ggcatctcga tccagcatat ctcctcgttt cgcgggttgg 6000 ggcggctttc gctgtacggc agtagtcggt gctcgtccag acgggccagg gtcatgtctt 6060 tccacgggcg cagggtcctc gtcagcgtag tctgggtcac ggtgaagggg tgcgctccgg 6120 gctgcgcgct ggccagggtg cgcttgaggc tggtcctgct ggtgctgaag cgctgccggt 6180 cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt gtcatagtcc agcccctccg 6240 cggcgtggcc cttggcgcgc agcttgccct tggaggaggc gccgcacgag gggcagtgca 6300 gacttttgag ggcgtagagc ttgggcgcga gaaataccga ttccggggag taggcatccg 6360 cgccgcaggc cccgcagacg gtctcgcatt ccacgagcca ggtgagctct ggccgttcgg 6420 ggtcaaaaac caggtttccc ccatgctttt tgatgcgttt cttacctctg gtttccatga 6480 gccggtgtcc acgctcggtg acgaaaaggc tgtccgtgtc cccgtataca gacttgagag 6540 gcctgtcctc gagcggtgtt ccgcggtcct cctcgtatag aaactcggac cactctgaga 6600 caaaggctcg cgtccaggcc agcacgaagg aggctaagtg ggaggggtag cggtcgttgt 6660 ccactagggg gtccactcgc tccagggtgt gaagacacat gtcgccctct tcggcatcaa 6720 ggaaggtgat tggtttgtag gtgtaggcca cgtgaccggg tgttcctgaa ggggggctat 6780 aaaagggggt gggggcgcgt tcgtcctcac tctcttccgc atcgctgtct gcgagggcca 6840 gctgttgggg tgagtactcc ctctgaaaag cgggcatgac ttctgcgcta agattgtcag 6900 tttccaaaaa cgaggaggat ttgatattca cctggcccgc ggtgatgcct ttgagggtgg 6960 ccgcatccat ctggtcagaa aagacaatct ttttgttgtc aagcttggtg gcaaacgacc 7020 cgtagagggc gttggacagc aacttggcga tggagcgcag ggtttggttt ttgtcgcgat 7080 cggcgcgctc cttggccgcg atgtttagct gcacgtattc gcgcgcaacg caccgccatt 7140 cgggaaagac ggtggtgcgc tcgtcgggca ccaggtgcac gcgccaaccg cggttgtgca 7200 gggtgacaag gtcaacgctg gtggctacct ctccgcgtag gcgctcgttg gtccagcaga 7260 ggcggccgcc cttgcgcgag cagaatggcg gtagggggtc tagctgcgtc tcgtccgggg 7320 ggtctgcgtc cacggtaaag accccgggca gcaggcgcgc gtcgaagtag tctatcttgc 7380 atccttgcaa gtctagcgcc tgctgccatg cgcgggcggc aagcgcgcgc tcgtatgggt 7440 tgagtggggg accccatggc atggggtggg tgagcgcgga ggcgtacatg ccgcaaatgt 7500 cgtaaacgta gaggggctct ctgagtattc caagatatgt agggtagcat cttccaccgc 7560 ggatgctggc gcgcacgtaa tcgtatagtt cgtgcgaggg agcgaggagg tcgggaccga 7620 ggttgctacg ggcgggctgc tctgctcgga agactatctg cctgaagatg gcatgtgagt 7680 tggatgatat ggttggacgc tggaagacgt tgaagctggc gtctgtgaga cctaccgcgt 7740 cacgcacgaa ggaggcgtag gagtcgcgca gcttgttgac cagctcggcg gtgacctgca 7800 cgtctagggc gcagtagtcc agggtttcct tgatgatgtc atacttatcc tgtccctttt 7860 ttttccacag ctcgcggttg aggacaaact cttcgcggtc tttccagtac tcttggatcg 7920 gaaacccgtc ggcctccgaa cggtaagagc ctagcatgta gaactggttg acggcctggt 7980 aggcgcagca tcccttttct acgggtagcg cgtatgcctg cgcggccttc cggagcgagg 8040 tgtgggtgag cgcaaaggtg tccctgacca tgactttgag gtactggtat ttgaagtcag 8100 tgtcgtcgca tccgccctgc tcccagagca aaaagtccgt gcgctttttg gaacgcggat 8160 ttggcagggc gaaggtgaca tcgttgaaga gtatctttcc cgcgcgaggc ataaagttgc 8220 gtgtgatgcg gaagggtccc ggcacctcgg aacggttgtt aattacctgg gcggcgagca 8280 cgatctcgtc aaagccgttg atgttgtggc ccacaatgta aagttccaag aagcgcggga 8340 tgcccttgat ggaaggcaat tttttaagtt cctcgtaggt gagctcttca ggggagctga 8400 gcccgtgctc tgaaagggcc cagtctgcaa gatgagggtt ggaagcgacg aatgagctcc 8460 acaggtcacg ggccattagc atttgcaggt ggtcgcgaaa ggtcctaaac tggcgaccta 8520 tggccatttt ttctggggtg atgcagtaga aggtaagcgg gtcttgttcc cagcggtccc 8580 atccaaggtt cgcggctagg tctcgcgcgg cagtcactag aggctcatct ccgccgaact 8640 tcatgaccag catgaagggc acgagctgct tcccaaaggc ccccatccaa gtataggtct 8700 ctacatcgta ggtgacaaag agacgctcgg tgcgaggatg cgagccgatc gggaagaact 8760 ggatctcccg ccaccaattg gaggagtggc tattgatgtg gtgaaagtag aagtccctgc 8820 gacgggccga acactcgtgc tggcttttgt aaaaacgtgc gcagtactgg cagcggtgca 8880 cgggctgtac atcctgcacg aggttgacct gacgaccgcg cacaaggaag cagagtggga 8940 atttgagccc ctcgcctggc gggtttggct ggtggtcttc tacttcggct gcttgtcctt 9000 gaccgtctgg ctgctcgagg ggagttacgg tggatcggac caccacgccg cgcgagccca 9060 aagtccagat gtccgcgcgc ggcggtcgga gcttgatgac aacatcgcgc agatgggagc 9120 tgtccatggt ctggagctcc cgcggcgtca ggtcaggcgg gagctcctgc aggtttacct 9180 cgcatagacg ggtcagggcg cgggctagat ccaggtgata cctaatttcc aggggctggt 9240 tggtggcggc gtcgatggct tgcaagaggc cgcatccccg cggcgcgact acggtaccgc 9300 gcggcgggcg gtgggccgcg ggggtgtcct tggatgatgc atctaaaagc ggtgacgcgg 9360 gcgagccccc ggaggtaggg ggggctccgg acccgccggg agagggggca ggggcacgtc 9420 ggcgccgcgc gcgggcagga gctggtgctg cgcgcgtagg ttgctggcga acgcgacgac 9480 gcggcggttg atctcctgaa tctggcgcct ctgcgtgaag acgacgggcc cggtgagctt 9540 gagcctgaaa gagagttcga cagaatcaat ttcggtgtcg ttgacggcgg cctggcgcaa 9600 aatctcctgc acgtctcctg agttgtcttg ataggcgatc tcggccatga actgctcgat 9660 ctcttcctcc tggagatctc cgcgtccggc tcgctccacg gtggcggcga ggtcgttgga 9720 aatgcgggcc atgagctgcg agaaggcgtt gaggcctccc tcgttccaga cgcggctgta 9780 gaccacgccc ccttcggcat cgcgggcgcg catgaccacc tgcgcgagat tgagctccac 9840 gtgccgggcg aagacggcgt agtttcgcag gcgctgaaag aggtagttga gggtggtggc 9900 ggtgtgttct gccacgaaga agtacataac ccagcgtcgc aacgtggatt cgttgatatc 9960 ccccaaggcc tcaaggcgct ccatggcctc gtagaagtcc acggcgaagt tgaaaaactg 10020 ggagttgcgc gccgacacgg ttaactcctc ctccagaaga cggatgagct cggcgacagt 10080 gtcgcgcacc tcgcgctcaa aggctacagg ggcctcttct tcttcttcaa tctcctcttc 10140 cataagggcc tccccttctt cttcttctgg cggcggtggg ggagggggga cacggcggcg 10200 acgacggcgc accgggaggc ggtcgacaaa gcgctcgatc atctccccgc ggcgacggcg 10260 catggtctcg gtgacggcgc ggccgttctc gcgggggcgc agttggaaga cgccgcccgt 10320 catgtcccgg ttatgggttg gcggggggct gccatgcggc agggatacgg cgctaacgat 10380 gcatctcaac aattgttgtg taggtactcc gccgccgagg gacctgagcg agtccgcatc 10440 gaccggatcg gaaaacctct cgagaaaggc gtctaaccag tcacagtcgc aaggtaggct 10500 gagcaccgtg gcgggcggca gcgggcggcg gtcggggttg tttctggcgg aggtgctgct 10560 gatgatgtaa ttaaagtagg cggtcttgag acggcggatg gtcgacagaa gcaccatgtc 10620 cttgggtccg gcctgctgaa tgcgcaggcg gtcggccatg ccccaggctt cgttttgaca 10680 tcggcgcagg tctttgtagt agtcttgcat gagcctttct accggcactt cttcttctcc 10740 ttcctcttgt cctgcatctc ttgcatctat cgctgcggcg gcggcggagt ttggccgtag 10800 gtggcgccct cttcctccca tgcgtgtgac cccgaagccc ctcatcggct gaagcagggc 10860 taggtcggcg acaacgcgct cggctaatat ggcctgctgc acctgcgtga gggtagactg 10920 gaagtcatcc atgtccacaa agcggtggta tgcgcccgtg ttgatggtgt aagtgcagtt 10980 ggccataacg gaccagttaa cggtctggtg acccggctgc gagagctcgg tgtacctgag 11040 acgcgagtaa gccctcgagt caaatacgta gtcgttgcaa gtccgcacca ggtactggta 11100 tcccaccaaa aagtgcggcg gcggctggcg gtagaggggc cagcgtaggg tggccggggc 11160 tccgggggcg agatcttcca acataaggcg atgatatccg tagatgtacc tggacatcca 11220 ggtgatgccg gcggcggtgg tggaggcgcg cggaaagtcg cggacgcggt tccagatgtt 11280 gcgcagcggc aaaaagtgct ccatggtcgg gacgctctgg ccggtcaggc gcgcgcaatc 11340 gttgacgctc tagaccgtgc aaaaggagag cctgtaagcg ggcactcttc cgtggtctgg 11400 tggataaatt cgcaagggta tcatggcgga cgaccggggt tcgagccccg tatccggccg 11460 tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc caggtgtgcg acgtcagaca 11520 acgggggagt gctccttttg gcttccttcc aggcgcggcg gctgctgcgc tagctttttt 11580 ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa gcgaaagcat taagtggctc 11640 gctccctgta gccggagggt tattttccaa gggttgagtc gcgggacccc cggttcgagt 11700 ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc ccgtcatgca agaccccgct 11760 tgcaaattcc tccggaaaca gggacgagcc ccttttttgc ttttcccaga tgcatccggt 11820 gctgcggcag atgcgccccc ctcctcagca gcggcaagag caagagcagc ggcagacatg 11880 cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg acatccgcgg ttgacgcggc 11940 agcagatggt gattacgaac ccccgcggcg ccgggcccgg cactacctgg acttggagga 12000 gggcgagggc ctggcgcggc taggagcgcc ctctcctgag cggtacccaa gggtgcagct 12060 gaagcgtgat acgcgtgagg cgtacgtgcc gcggcagaac ctgtttcgcg accgcgaggg 12120 agaggagccc gaggagatgc gggatcgaaa gttccacgca gggcgcgagc tgcggcatgg 12180 cctgaatcgc gagcggttgc tgcgcgagga ggactttgag cccgacgcgc gaaccgggat 12240 tagtcccgcg cgcgcacacg tggcggccgc cgacctggta accgcatacg agcagacggt 12300 gaaccaggag attaactttc aaaaaagctt taacaaccac gtgcgtacgc ttgtggcgcg 12360 cgaggaggtg gctataggac tgatgcatct gtgggacttt gtaagcgcgc tggagcaaaa 12420 cccaaatagc aagccgctca tggcgcagct gttccttata gtgcagcaca gcagggacaa 12480 cgaggcattc agggatgcgc tgctaaacat agtagagccc gagggccgct ggctgctcga 12540 tttgataaac atcctgcaga gcatagtggt gcaggagcgc agcttgagcc tggctgacaa 12600 ggtggccgcc atcaactatt ccatgcttag cctgggcaag ttttacgccc gcaagatata 12660 ccatacccct tacgttccca tagacaagga ggtaaagatc gaggggttct acatgcgcat 12720 ggcgctgaag gtgcttacct tgagcgacga cctgggcgtt tatcgcaacg agcgcatcca 12780 caaggccgtg agcgtgagcc ggcggcgcga gctcagcgac cgcgagctga tgcacagcct 12840 gcaaagggcc ctggctggca cgggcagcgg cgatagagag gccgagtcct actttgacgc 12900 gggcgctgac ctgcgctggg ccccaagccg acgcgccctg gaggcagctg gggccggacc 12960 tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc ggcgtggagg aatatgacga 13020 ggacgatgag tacgagccag aggacggcga gtactaagcg gtgatgtttc tgatcagatg 13080 atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc agagccagcc gtccggcctt 13140 aactccacgg acgactggcg ccaggtcatg gaccgcatca tgtcgctgac tgcgcgcaat 13200 cctgacgcgt tccggcagca gccgcaggcc aaccggctct ccgcaattct ggaagcggtg 13260 gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg cgatcgtaaa cgcgctggcc 13320 gaaaacaggg ccatccggcc cgacgaggcc ggcctggtct acgacgcgct gcttcagcgc 13380 gtggctcgtt acaacagcgg caacgtgcag accaacctgg accggctggt gggggatgtg 13440 cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg gcaacctggg ctccatggtt 13500 gcactaaacg ccttcctgag tacacagccc gccaacgtgc cgcggggaca ggaggactac 13560 accaactttg tgagcgcact gcggctaatg gtgactgaga caccgcaaag tgaggtgtac 13620 cagtctgggc cagactattt tttccagacc agtagacaag gcctgcagac cgtaaacctg 13680 agccaggctt tcaaaaactt gcaggggctg tggggggtgc gggctcccac aggcgaccgc 13740 gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt tgctgctgct aatagcgccc 13800 ttcacggaca gtggcagcgt gtcccgggac acatacctag gtcacttgct gacactgtac 13860 cgcgaggcca taggtcaggc gcatgtggac gagcatactt tccaggagat tacaagtgtc 13920 agccgcgcgc tggggcagga ggacacgggc agcctggagg caaccctaaa ctacctgctg 13980 accaaccggc ggcagaagat cccctcgttg cacagtttaa acagcgagga ggagcgcatt 14040 ttgcgctacg tgcagcagag cgtgagcctt aacctgatgc gcgacggggt aacgcccagc 14100 gtggcgctgg acatgaccgc gcgcaacatg gaaccgggca tgtatgcctc aaaccggccg 14160 tttatcaacc gcctaatgga ctacttgcat cgcgcggccg ccgtgaaccc cgagtatttc 14220 accaatgcca tcttgaaccc gcactggcta ccgccccctg gtttctacac cgggggattc 14280 gaggtgcccg agggtaacga tggattcctc tgggacgaca tagacgacag cgtgttttcc 14340 ccgcaaccgc agaccctgct agagttgcaa cagcgcgagc aggcagaggc ggcgctgcga 14400 aaggaaagct tccgcaggcc aagcagcttg tccgatctag gcgctgcggc cccgcggtca 14460 gatgctagta gcccatttcc aagcttgata gggtctctta ccagcactcg caccacccgc 14520 ccgcgcctgc tgggcgagga ggagtaccta aacaactcgc tgctgcagcc gcagcgcgaa 14580 aaaaacctgc ctccggcatt tcccaacaac gggatagaga gcctagtgga caagatgagt 14640 agatggaaga cgtacgcgca ggagcacagg gacgtgccag gcccgcgccc gcccacccgt 14700 cgtcaaaggc acgaccgtca gcggggtctg gtgtgggagg acgatgactc ggcagacgac 14760 agcagcgtcc tggatttggg agggagtggc aacccgtttg cgcaccttcg ccccaggctg 14820 gggagaatgt tttaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg 14880 gcaccgagcg ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg 14940 aaggtcctcc tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg 15000 gttctccctt cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta 15060 ccggggggag aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg 15120 tgtacctggt ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca 15180 gcaactttct gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac 15240 agaccatcaa tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata 15300 ccaacatgcc aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg 15360 tgtcgcgctt gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca 15420 cgctgcccga gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg 15480 tggagcacta cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa 15540 agtttgacac ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg 15600 gggtatatac aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg 15660 acttcaccca cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg 15720 agggctttag gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg 15780 tggacgccta ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg 15840 gcagcaacag cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc 15900 agccggtgga ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg 15960 aggagaagcg cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg 16020 aggtcgagaa gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac 16080 gcagttacaa cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg 16140 catacaacta cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg 16200 acgtaacctg cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg 16260 tgaccttccg ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc 16320 ccgtgcactc caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt 16380 ttacctctct gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc 16440 cagcccccac catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc 16500 taccgctgcg caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc 16560 gcacctgccc ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc 16620 gcactttttg agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc 16680 tgcgcttccc aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc 16740 gcgtgcgcgg gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca 16800 ccaccgtcga tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc 16860 cgccaccagt gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct 16920 atgctaaaat gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca 16980 ctgccgccca acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg 17040 cggccatgcg ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca 17100 ggcgacgagc ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg 17160 gcaacgtgta ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc 17220 ccccgcgcaa ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag 17280 cggcggcggc gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg 17340 tcatcgcgcc ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa 17400 agctaaagcg ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg 17460 aactgctgca cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac 17520 gtgttttgcg acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct 17580 acaagcgcgt gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc 17640 gcctcgggga gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg 17700 agggcaaccc aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg 17760 caccgtccga agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc 17820 agctgatggt acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac 17880 ctgggctgga gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg 17940 tgcagaccgt ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag 18000 agggcatgga gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg 18060 cggtcgctgc ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc 18120 gcgtttcagc cccccggcgc ccgcgcggtt cgaggaagta cggcgccgcc agcgcgctac 18180 tgcccgaata tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct 18240 accgccccag aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc 18300 gtcgccgtcg ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag 18360 gcaggaccct ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct 18420 ttgtggttct tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc 18480 gaggaagaat gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc 18540 gtgcgcacca ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc 18600 tccttattcc actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct 18660 tgcaggcgca gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt 18720 ctggactctc acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt 18780 gcgtctctgg ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc 18840 accagcaata tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat 18900 ttcggttcca ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg 18960 ctgagggata agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct 19020 ggcattagcg gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag 19080 cttgatcccc gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag 19140 gggcgtggcg aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac 19200 gagcctccct cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg 19260 cccatggcta ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc 19320 gccgacaccc agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct 19380 agccgcgcgt ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt 19440 ggcaactggc aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc 19500 cgacgatgct tctgaatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc 19560 gccagaggag ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga 19620 tgccgcagtg gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg 19680 ggctggtgca gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa 19740 accccacggt ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc 19800 ggttcatccc tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag 19860 ctgtgggtga taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc 19920 tggacagggg ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca 19980 agggtgcccc aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag 20040 aagaagagga cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc 20100 acgtatttgg gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag 20160 gtgtcgaagg tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag 20220 gagaatctca gtggtacgaa actgaaatta atcatgcagc tgggagagtc cttaaaaaga 20280 ctaccccaat gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc 20340 aaggcattct tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt 20400 tctcaactac tgaggcgacc gcaggcaatg gtgataactt gactcctaaa gtggtattgt 20460 acagtgaaga tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta 20520 aggaaggtaa ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca 20580 ttgcttttag ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg 20640 ttctggcggg ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag 20700 agctttcata ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt 20760 ggaatcaggc tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg 20820 aagatgaact tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta 20880 ccaaggtaaa acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt 20940 cagataaaaa tgaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca 21000 acctgtggag aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt 21060 acagtccttc caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc 21120 gagtggtggc tcccgggtta gtggactgct acattaacct tggagcacgc tggtcccttg 21180 actatatgga caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct 21240 caatgttgct gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct 21300 ttgccattaa aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga 21360 aggatgttaa catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca 21420 gcattaagtt tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg 21480 cctccacgct tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc 21540 tctccgccgc caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca 21600 tcccctcccg caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg 21660 aaaccccatc actgggctcg ggctacgacc cttattacac ctactctggc tctataccct 21720 acctagatgg aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact 21780 cttctgtcag ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc 21840 gctcagttga cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc 21900 tggtacaaat gctagctaac tacaacattg gctaccaggg cttctatatc ccagagagct 21960 acaaggaccg catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg 22020 atgatactaa atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg 22080 gatttgttgg ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc 22140 cctatccgct tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg 22200 atcgcaccct ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag 22260 acctgggcca aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg 22320 tggatcccat ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc 22380 gtgtgcaccg gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg 22440 ccggcaacgc cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc 22500 cagtgagcag gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg 22560 cacctatgac aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt 22620 caatacggcc ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca 22680 ctcaaaaaca tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt 22740 ttaccagttt gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg 22800 ctgtataacg ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg 22860 actattctgc tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca 22920 caaccccacc atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt 22980 acagcccacc ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc 23040 ctacttccgc agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa 23100 catgtaaaaa taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac 23160 tctcgggtga ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt 23220 ctgccgcgca tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct 23280 ccacttaaac tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct 23340 gcgcaccatc accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg 23400 gcctccgccc tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag 23460 cgccgggtgg tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc 23520 ctccgcgttg ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc 23580 gtgcccaggc tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt 23640 ctgggcgtta ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc 23700 ctttgcgcct tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca 23760 ggccgcgtcg tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc 23820 ccaccggttc ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt 23880 ttcgctcgtc acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag 23940 acacttaagc tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg 24000 ctcgtgatgc ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc 24060 catcatcgtc acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc 24120 gttcagccag gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa 24180 gttcgccttt agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat 24240 gcccttctcc cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact 24300 ttccgcttcg ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc 24360 gtcttcattc agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg 24420 tgggttgctg aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac 24480 gattacctct ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt 24540 gggcgcaatg gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac 24600 cagcgcgtct tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt 24660 ttttgggggc gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt 24720 tgggggacgt cgcgccgcac cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc 24780 ccgactggcc atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa 24840 ggacagccta accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc 24900 gcctaccacc ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca 24960 ggacccaggt tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa 25020 gcaagaccag gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca 25080 tggcgactac ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc 25140 cattatctgc gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag 25200 ccttgcctac gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg 25260 cacatgcgag cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct 25320 tgccacctat cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg 25380 cagccgagcg gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc 25440 gctcaacgaa gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa 25500 cgctctgcaa caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga 25560 gggtgacaac gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta 25620 cccggcactt aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg 25680 ccgtgcgcag cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc 25740 cgcagttggc gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga 25800 ggagcgacgc aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca 25860 gcggttcttt gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt 25920 tcgacagggc tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt 25980 ctcctacctt ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct 26040 caagggcgag gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac 26100 ctggcagacg gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct 26160 gcagaaactg ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt 26220 ggccgcgcac ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg 26280 tctgccagac ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg 26340 ctcaggaatc ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta 26400 ccgcgaatgc cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct 26460 tgcctaccac tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg 26520 tcgctgcaac ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga 26580 aagtcaaatt atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc 26640 tccggggttg aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc 26700 tgaggactac cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccaaatgc 26760 ggagcttacc gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa 26820 caaagcccgc caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc 26880 cggcgaggag ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc 26940 ccttgcttcc caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg 27000 aggaggaata ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga 27060 tggaagactg ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa 27120 caccgtcacc ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca 27180 gcatggctac aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc 27240 gtagatggga caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc 27300 aagagcaaca acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg 27360 cttgcttgca agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc 27420 acggcgtggc cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact 27480 gcaccggcgg cagcggcagc ggcagcaaca gcagcggcca cacagaagca aaggcgaccg 27540 gatagcaaga ctctgacaaa gcccaagaaa tccacagcgg cggcagcagc aggaggagga 27600 gcgctgcgtc tggcgcccaa cgaacccgta tcgacccgcg agcttagaaa caggattttt 27660 cccactctgt atgctatatt tcaacagagc aggggccaag aacaagagct gaaaataaaa 27720 aacaggtctc tgcgatccct cacccgcagc tgcctgtatc acaaaagcga agatcagctt 27780 cggcgcacgc tggaagacgc ggaggctctc ttcagtaaat actgcgcgct gactcttaag 27840 gactagtttc gcgccctttc tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca 27900 cacccggcgc cagcacctgt cgtcagcgcc atttcaactt tgtatacaaa agttgtgatg 27960 agcaaggaaa ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct 28020 ggagctgccc aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata 28080 tcccgggtca acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt 28140 accaccacac ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag 28200 gaaagtcccg ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg 28260 actaactcag gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag 28320 ggtataactc acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc 28380 tcctcgcttg gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca 28440 ttcacgcctc gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga 28500 ggcattggaa ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc 28560 tcgggacctc ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac 28620 tcggcggacg gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac 28680 ctggtccact gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt 28740 gaattgcccg aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga 28800 gagcttgccc gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac 28860 aggggaccct gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat 28920 ctttgttgcc atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc 28980 ctatcgccat cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt 29040 acctggtact tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt 29100 gagtctacga gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct 29160 tacctgccgg gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg 29220 taaaccagac tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc 29280 ttagaaaacc cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt 29340 caagcaactc tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc 29400 tctgtcttgt gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct 29460 gctgtgtgca catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat 29520 gattaggtac ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa 29580 ggtggatttt aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac 29640 cactcttata aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat 29700 tggcaagtat gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac 29760 agttttccag ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg 29820 cgacattacc atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga 29880 aaacactggc actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac 29940 cctactctat attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta 30000 atttactaag ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca 30060 aattcaaaaa gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct 30120 caataccatt cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg 30180 aagtcaggct tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt 30240 tccagtccaa ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc 30300 cgctaccgga cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg 30360 ggataacttg ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat 30420 gtggctcatc tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat 30480 tgtgctacac ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt 30540 ttctcttaca gtatgattaa atgagacatg gccgttcagc tggtggaaag tggcgggggt 30600 tctgttcagg cgggcgggtc tctgaggctt acttgcgccg cgagtggtag aaccagtcgg 30660 agctacggaa tggggtggtt taggcaagct cccgggaaag aacgcgaatt tgtgagcggc 30720 attagctggc ggggcgattc cactgggtac gcagactctg taaagggaag gtttaccatc 30780 agccgcgata acgcaaagaa caccgttgat ctgcagatga atagcttgag accggaggac 30840 accgccatct actactgtgc agctgccgcc ggaagcacat ggtatgggac tctgtatgaa 30900 tacgactact ggggccaggg tacacaagtt accgtaagca gcggctctgg gtccggctcg 30960 accggagtgc aggtggaaac catctcccca ggagacgggc gcaccttccc caagcgcggc 31020 cagacctgcg tggtgcacta caccgggatg cttgaagatg gaaagaaatt tgattcctcc 31080 cgggacagaa acaagccctt taagtttatg ctaggcaagc aggaggtgat ccgaggctgg 31140 gaagaagggg ttgcccagat gagtgtgggt cagagagcca aactgactat atctccagat 31200 tatgcctatg gtgccactgg gcacccaggc atcatcccac cacatgccac tctcgtcttc 31260 gatgtggagc ttctaaaact gtaataaaaa aaaataataa agcatcactt acttaaaatc 31320 agttagcaaa tttctgtcca gtttattcag cagcacctcc ttgccctcct cccagctctg 31380 gtattgcagc ttcctcctgg ctgcaaactt tctccacaat ctaaatggaa tgtcagtttc 31440 ctcctgttcc tgtccatccg cacccactat cttcatgttg ttgcagatga agcgcgcaag 31500 accgtctgaa gataccttca accccgtgta tccatatgac acggaaaccg gtcctccaac 31560 tgtgcctttt cttactcctc cctttgtatc ccccaatggg tttcaagaga gtccccctgg 31620 ggtactctct ttgcgcctat ccgaacctct agttacctcc aatggcatgc ttgcgctcaa 31680 aatgggcaac ggcctctctc tggacgaggc cggcaacctt acctcccaaa atgtaaccac 31740 tgtgagccca cctctcaaaa aaaccaagtc aaacataaac ctggaaatat ctgcacccct 31800 cacagttacc tcagaagccc taactgtggc tgccgccgca cctctaatgg tcgcgggcaa 31860 cacactcacc atgcaatcac aggccccgct aaccgtgcac gactccaaac ttagcattgc 31920 cacccaagga cccctcacag tgtcagaagg aaagctagcc ctgcaaacat caggccccct 31980 caccaccacc gatagcagta cccttactat cactgcctca ccccctctaa ctactgccac 32040 tggtagcttg ggcattgact tgaaagagcc catttataca caaaatggaa aactaggact 32100 aaagtacggg gctcctttgc atgtaacaga cgacctaaac actttgaccg tagcaactgg 32160 tccaggtgtg actattaata atacttcctt gcaaactaaa gttactggag ccttgggttt 32220 tgattcacaa ggcaatatgc aacttaatgt agcaggagga ctaaggattg attctcaaaa 32280 cagacgcctt atacttgatg ttagttatcc gtttgatgct caaaaccaac taaatctaag 32340 actaggacag ggccctcttt ttataaactc agcccacaac ttggatatta actacaacaa 32400 aggcctttac ttgtttacag cttcaaacaa ttccaaaaag cttgaggtta acctaagcac 32460 tgccaagggg ttgatgtttg acgctacagc catagccatt aatgcaggag atgggcttga 32520 atttggttca cctaatgcac caaacacaaa tcccctcaaa acaaaaattg gccatggcct 32580 agaatttgat tcaaacaagg ctatggttcc taaactagga actggcctta gttttgacag 32640 cacaggtgcc attacagtag gaaacaaaaa taatgataag ctaactttgt ggaccacacc 32700 agctccatct cctaactgta gactaaatgc agagaaagat gctaaactca ctttggtctt 32760 aacaaaatgt ggcagtcaaa tacttgctac agtttcagtt ttggctgtta aaggcagttt 32820 ggctccaata tctggaacag ttcaaagtgc tcatcttatt ataagatttg acgaaaatgg 32880 agtgctacta aacaattcct tcctggaccc agaatattgg aactttagaa atggagatct 32940 tactgaaggc acagcctata caaacgctgt tggatttatg cctaacctat cagcttatcc 33000 aaaatctcac ggtaaaactg ccaaaagtaa cattgtcagt caagtttact taaacggaga 33060 caaaactaaa cctgtaacac taaccattac actaaacggt acacaggaaa caggagacac 33120 aactgagatg tggcatgaag gcctagaaga ggcctctcgc ttgtactttg gggagaggaa 33180 cgtcaaaggc atgtttgagg tgctggagcc cctgcatgct atgatggaac gcggtcccca 33240 gaccctgaag gaaacgtcct ttaatcaggc atatggtcga gatttaatgg aggcacaaga 33300 atggtgccga aagtacatga aatcagggaa cgtcaaggac ctcacccaag cctgggacct 33360 ctactatcac gtgttcagac gaatctcaaa gcagccaagt gcatactcta tgtcattttc 33420 atgggactgg tctggccaca actacattaa tgaaatattt gccacatcct cttacacttt 33480 ttcatacatt gcccaagaat aaagaatcgt ttgtgttatg tttcaacgtg tttatttttc 33540 aattgcagaa aatttcaagt catttttcat tcagtagtat agccccacca ccacatagct 33600 tatacagatc accgtacctc aactttgtat aataaagttg taatcaaact cacagaaccc 33660 tagtattcaa cctgccacct ccctcccaac acacagagta cacagtcctt tctccccggc 33720 tggccttaaa aagcatcata tcatgggtaa cagacatatt cttaggtgtt atattccaca 33780 cggtttcctg tcgagccaaa cgctcatcag tgatattaat aaactccccg ggcagctcac 33840 ttaagttcat gtcgctgtcc agctgctgag ccacaggctg ctgtccaact tgcggttgct 33900 taacgggcgg cgaaggagaa gtccacgcct acatgggggt agagtcataa tcgtgcatca 33960 ggatagggcg gtggtgctgc agcagcgcgc gaataaactg ctgccgccgc cgctccgtcc 34020 tgcaggaata caacatggca gtggtctcct cagcgatgat tcgcaccgcc cgcagcataa 34080 ggcgccttgt cctccgggca cagcagcgca ccctgatctc acttaaatca gcacagtaac 34140 tgcagcacag caccacaata ttgttcaaaa tcccacagtg caaggcgctg tatccaaagc 34200 tcatggcggg gaccacagaa cccacgtggc catcatacca caagcgcagg tagattaagt 34260 ggcgacccct cataaacacg ctggacataa acattacctc ttttggcatg ttgtaattca 34320 ccacctcccg gtaccatata aacctctgat taaacatggc gccatccacc accatcctaa 34380 accagctggc caaaacctgc ccgccggcta tacactgcag ggaaccggga ctggaacaat 34440 gacagtggag agcccaggac tcgtaaccat ggatcatcat gctcgtcatg atatcaatgt 34500 tggcacaaca caggcacacg tgcatacact tcctcaggat tacaagctcc tcccgcgtta 34560 gaaccatatc ccagggaaca acccattcct gaatcagcgt aaatcccaca ctgcagggaa 34620 gacctcgcac gtaactcacg ttgtgcattg tcaaagtgtt acattcgggc agcagcggat 34680 gatcctccag tatggtagcg cgggtttctg tctcaaaagg aggtagacga tccctactgt 34740 acggagtgcg ccgagacaac cgagatcgtg ttggtcgtag tgtcatgcca aatggaacgc 34800 cggacgtagt catatttcct gaagcaaaac caggtgcggg cgtgacaaac agatctgcgt 34860 ctccggtctc gccgcttaga tcgctctgtg tagtagttgt agtatatcca ctctctcaaa 34920 gcatccaggc gccccctggc ttcgggttct atgtaaactc cttcatgcgc cgctgccctg 34980 ataacatcca ccaccgcaga ataagccaca cccagccaac ctacacattc gttctgcgag 35040 tcacacacgg gaggagcggg aagagctgga agaaccatgt tttttttttt attccaaaag 35100 attatccaaa acctcaaaat gaagatctat taagtgaacg cgctcccctc cggtggcgtg 35160 gtcaaactct acagccaaag aacagataat ggcatttgta agatgttgca caatggcttc 35220 caaaaggcaa acggccctca cgtccaagtg gacgtaaagg ctaaaccctt cagggtgaat 35280 ctcctctata aacattccag caccttcaac catgcccaaa taattctcat ctcgccacct 35340 tctcaatata tctctaagca aatcccgaat attaagtccg gccattgtaa aaatctgctc 35400 cagagcgccc tccaccttca gcctcaagca gcgaatcatg attgcaaaaa ttcaggttcc 35460 tcacagacct gtataagatt caaaagcgga acattaacaa aaataccgcg atcccgtagg 35520 tcccttcgca gggccagctg aacataatcg tgcaggtctg cacggaccag cgcggccact 35580 tccccgccag gaaccatgac aaaagaaccc acactgatta tgacacgcat actcggagct 35640 atgctaacca gcgtagcccc gatgtaagct tgttgcatgg gcggcgatat aaaatgcaag 35700 gtgctgctca aaaaatcagg caaagcctcg cgcaaaaaag aaagcacatc gtagtcatgc 35760 tcatgcagat aaaggcaggt aagctccgga accaccacag aaaaagacac catttttctc 35820 tcaaacatgt ctgcgggttt ctgcataaac acaaaataaa ataacaaaaa aacatttaaa 35880 cattagaagc ctgtcttaca acaggaaaaa caacccttat aagcataaga cggactacgg 35940 ccatgccggc gtgaccgtaa aaaaactggt caccgtgatt aaaaagcacc accgacagct 36000 cctcggtcat gtccggagtc ataatgtaag actcggtaaa cacatcaggt tgattcacat 36060 cggtcagtgc taaaaagcga ccgaaatagc ccgggggaat acatacccgc aggcgtagag 36120 acaacattac agcccccata ggaggtataa caaaattaat aggagagaaa aacacataaa 36180 cacctgaaaa accctcctgc ctaggcaaaa tagcaccctc ccgctccaga acaacataca 36240 gcgcttccac agcggcagcc ataacagtca gccttaccag taaaaaagaa aacctattaa 36300 aaaaacacca ctcgacacgg caccagctca atcagtcaca gtgtaaaaaa gggccaagtg 36360 cagagcgagt atatatagga ctaaaaaatg acgtaacggt taaagtccac aaaaaacacc 36420 cagaaaaccg cacgcgaacc tacgcccaga aacgaaagcc aaaaaaccca caacttcctc 36480 aaatcgtcac ttccgttttc ccacgttacg tcacttccca ttttaagaaa actacaattc 36540 ccaacacata caagttactc cgccctaaaa cctacgtcac ccgccccgtt cccacgcccc 36600 gcgccacgtc acaaactcca ccccctcatt atcatattgg cttcaatcca aaataaggta 36660 tattattgat gatg 36674 <210> 89 <211> 36404 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO206) <400> 89 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc 600 catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg 660 cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct 720 gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg 780 ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt 840 ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa 900 gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga 960 cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat 1020 ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga 1080 cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt 1140 gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga 1200 gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat 1260 ggacgagctg tacaagggaa gtggacggga gggaatgaga catattatct gccacggagg 1320 tgttattacc gaagaaatgg ccgccagtct tttggaccag ctgatcgaag aggtactggc 1380 tgataatctt ccacctccta gccattttga accacctacc cttcacgaac tgtatgattt 1440 agacgtgacg gcccccgaag atcccaacga ggaggcggtt tcgcagattt ttcccgactc 1500 tgtaatgttg gcggtgcagg aagggattga cttactcact tttccgccgg cgcccggttc 1560 tccggagccg cctcaccttt cccggcagcc cgagcagccg gagcagagag ccttgggtcc 1620 ggtttctatg ccaaaccttg taccggaggt gatcgatctt acctgccacg aggctggctt 1680 tccacccagt gacgacgagg atgaagaggg tgaggagttt gtgttagatt atgtggagca 1740 ccccgggcac ggttgcaggt cttgtcatta tcaccggagg aatacggggg acccagatat 1800 tatgtgttcg ctttgctata tgaggacctg tggcatgttt gtctacagta agtgaaaatt 1860 atgggcagtg ggtgatagag tggtgggttt ggtgtggtaa tttttttttt aatttttaca 1920 gttttgtggt ttaaagaatt ttgtattgtg atttttttaa aaggtcctgt gtctgaacct 1980 gagcctgagc ccgagccaga accggagcct gcaagaccta cccgccgtcc taaaatggcg 2040 cctgctatcc tgagacgccc gacatcacct gtgtctagag aatgcaatag tagtacggat 2100 agctgtgact ccggtccttc taacacacct cctgagatac acccggtggt cccgctgtgc 2160 cccattaaac cagttgccgt gagagttggt gggcgtcgcc aggctgtgga atgtatcgag 2220 gacttgctta acgagcctgg gcaacctttg gacttgagct gtaaacgccc caggccataa 2280 ggtgtaaacc tgtgattgcg tgtgtggtta acgcctttgt ttgctgaatg agttgatgta 2340 agtttaataa agggtgagat aatgtttaac ttgcatggcg tgttaaatgg ggcggggctt 2400 aaagggtata taatgcgccg tgggctaatc ttggttacat ctgacctcat ggaggcttgg 2460 gagtgtttgg aagatttttc tgctgtgcgt aacttgctgg aacagagctc taacagtacc 2520 tcttggtttt ggaggtttct gtggggctca tcccaggcaa agttagtctg cagaattaag 2580 gaggattaca agtgggaatt tgaagagctt ttgaaatcct gtggtgagct gtttgattct 2640 ttgaatctgg gtcaccaggc gcttttccaa gagaaggtca tcaagacttt ggatttttcc 2700 acaccggggc gcgctgcggc tgctgttgct tttttgagtt ttataaagga taaatggagc 2760 gaagaaaccc atctgagcgg ggggtacctg ctggattttc tggccatgca tctgtggaga 2820 gcggttgtga gacacaagaa tcgcctgcta ctgttgtctt ccgtccgccc ggcgataata 2880 ccgacggagg agcagcagca gcagcaggag gaagccaggc ggcggcggca ggagcagagc 2940 ccatggaacc cgagagccgg cctggaccct cgggaatgaa tgttgtacag gtggctgaac 3000 tgtatccaga actgagacgc attttgacaa ttacagagga tgggcagggg ctaaaggggg 3060 taaagaggga gcggggggct tgtgaggcta cagaggaggc taggaatcta gcttttagct 3120 taatgaccag acaccgtcct gagtgtatta cttttcaaca gatcaaggat aattgcgcta 3180 atgagcttga tctgctggcg cagaagtatt ccatagagca gctgaccact tactggctgc 3240 agccagggga tgattttgag gaggctatta gggtatatgc aaaggtggca cttaggccag 3300 attgcaagta caagatcagc aaacttgtaa atatcaggaa ttgttgctac atttctggga 3360 acggggccga ggtggagata gatacggagg atagggtggc ctttagatgt agcatgataa 3420 atatgtggcc gggggtgctt ggcatggacg gggtggttat tatgaatgta aggtttactg 3480 gccccaattt tagcggtacg gttttcctgg ccaataccaa ccttatccta cacggtgtaa 3540 gcttctatgg gtttaacaat acctgtgtgg aagcctggac cgatgtaagg gttcggggct 3600 gtgcctttta ctgctgctgg aagggggtgg tgtgtcgccc caaaagcagg gcttcaatta 3660 agaaatgcct ctttgaaagg tgtaccttgg gtatcctgtc tgagggtaac tccagggtgc 3720 gccacaatgt ggcctccgac tgtggttgct tcatgctagt gaaaagcgtg gctgtgatta 3780 agcataacat ggtatgtggc aactgcgagg acagggcctc tcagatgctg acctgctcgg 3840 acggcaactg tcacctgctg aagaccattc acgtagccag ccactctcgc aaggcctggc 3900 cagtgtttga gcataacata ctgacccgct gttccttgca tttgggtaac aggagggggg 3960 tgttcctacc ttaccaatgc aatttgagtc acactaagat attgcttgag cccgagagca 4020 tgtccaaggt gaacctgaac ggggtgtttg acatgaccat gaagatctgg aaggtgctga 4080 ggtacgatga gacccgcacc aggtgcagac cctgcgagtg tggcggtaaa catattagga 4140 accagcctgt gatgctggat gtgaccgagg agctgaggcc cgatcacttg gtgctggcct 4200 gcacccgcgc tgagtttggc tctagcgatg aagatacaga ttgaggtact gaaatgtgtg 4260 ggcgtggctt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct 4320 gttttgcagc agccgccgcc gcccaacttt tctatacaaa gttgtaatga gcaccaactc 4380 gtttgatgga agcattgtga gctcatattt gacaacgcgc atgcccccat gggccggggt 4440 gcgtcagaat gtgatgggct ccagcattga tggtcgcccc gtcctgcccg caaactctac 4500 taccttgacc tacgagaccg tgtctggaac gccgttggag actgcagcct ccgccgccgc 4560 ttcagccgct gcagccaccg cccgcgggat tgtgactgac tttgctttcc tgagcccgct 4620 tgcaagcagt gcagcttccc gttcatccgc ccgcgatgac aagttgacgg ctcttttggc 4680 acaattggat tctttgaccc gggaacttaa tgtcgtttct cagcagctgt tggatctgcg 4740 ccagcaggtt tctgccctga aggcttcctc ccctcccaat gcggtttaaa acataaataa 4800 aaaaccagac tctgtttgga tttggatcaa gcataagtgt cttgctgtct ttatttaggg 4860 gttttgcgcg cgcggtaggc ccgggaccag cggtctcggt cgttgagggt cctgtgtatt 4920 ttttccagga cgtggtaaag gtgactctgg atgttcagat acatgggcat aagcccgtct 4980 ctggggtgga ggtagcacca ctgcagagct tcatgctgcg gggtggtgtt gtagatgatc 5040 cagtcgtagc aggagcgctg ggcgtggtgc ctaaaaatgt ctttcagtag caagctgatt 5100 gccaggggca ggcccttggt gtaagtgttt acaaagcggt taagctggga tgggtgcata 5160 cgtggggata tgagatgcat cttggactgt atttttaggt tggctatgtt cccagccata 5220 tccctccggg gattcatgtt gtgcagaacc accagcacag tgtatccggt gcacttggga 5280 aatttgtcat gtagcttaga aggaaatgcg tggaagaact tggagacgcc cttgtgacct 5340 ccaagatttt ccatgcattc gtccataatg atggcaatgg gcccacgggc ggcggcctgg 5400 gcgaagatat ttctgggatc actaacgtca tagttgtgtt ccaggatgag atcgtcatag 5460 gccattttta caaagcgcgg gcggagggtg ccagactgcg gtataatggt tccatccggc 5520 ccaggggcgt agttaccctc acagatttgc atttcccacg ctttgagttc agatgggggg 5580 atcatgtcta cctgcggggc gatgaagaaa acggtttccg gggtagggga gatcagctgg 5640 gaagaaagca ggttcctgag cagctgcgac ttaccgcagc cggtgggccc gtaaatcaca 5700 cctattaccg ggtgcaactg gtagttaaga gagctgcagc tgccgtcatc cctgagcagg 5760 ggggccactt cgttaagcat gtccctgact cgcatgtttt ccctgaccaa atccgccaga 5820 aggcgctcgc cgcccagcga tagcagttct tgcaaggaag caaagttttt caacggtttg 5880 agaccgtccg ccgtaggcat gcttttgagc gtttgaccaa gcagttccag gcggtcccac 5940 agctcggtca cctgctctac ggcatctcga tccagcatat ctcctcgttt cgcgggttgg 6000 ggcggctttc gctgtacggc agtagtcggt gctcgtccag acgggccagg gtcatgtctt 6060 tccacgggcg cagggtcctc gtcagcgtag tctgggtcac ggtgaagggg tgcgctccgg 6120 gctgcgcgct ggccagggtg cgcttgaggc tggtcctgct ggtgctgaag cgctgccggt 6180 cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt gtcatagtcc agcccctccg 6240 cggcgtggcc cttggcgcgc agcttgccct tggaggaggc gccgcacgag gggcagtgca 6300 gacttttgag ggcgtagagc ttgggcgcga gaaataccga ttccggggag taggcatccg 6360 cgccgcaggc cccgcagacg gtctcgcatt ccacgagcca ggtgagctct ggccgttcgg 6420 ggtcaaaaac caggtttccc ccatgctttt tgatgcgttt cttacctctg gtttccatga 6480 gccggtgtcc acgctcggtg acgaaaaggc tgtccgtgtc cccgtataca gacttgagag 6540 gcctgtcctc gagcggtgtt ccgcggtcct cctcgtatag aaactcggac cactctgaga 6600 caaaggctcg cgtccaggcc agcacgaagg aggctaagtg ggaggggtag cggtcgttgt 6660 ccactagggg gtccactcgc tccagggtgt gaagacacat gtcgccctct tcggcatcaa 6720 ggaaggtgat tggtttgtag gtgtaggcca cgtgaccggg tgttcctgaa ggggggctat 6780 aaaagggggt gggggcgcgt tcgtcctcac tctcttccgc atcgctgtct gcgagggcca 6840 gctgttgggg tgagtactcc ctctgaaaag cgggcatgac ttctgcgcta agattgtcag 6900 tttccaaaaa cgaggaggat ttgatattca cctggcccgc ggtgatgcct ttgagggtgg 6960 ccgcatccat ctggtcagaa aagacaatct ttttgttgtc aagcttggtg gcaaacgacc 7020 cgtagagggc gttggacagc aacttggcga tggagcgcag ggtttggttt ttgtcgcgat 7080 cggcgcgctc cttggccgcg atgtttagct gcacgtattc gcgcgcaacg caccgccatt 7140 cgggaaagac ggtggtgcgc tcgtcgggca ccaggtgcac gcgccaaccg cggttgtgca 7200 gggtgacaag gtcaacgctg gtggctacct ctccgcgtag gcgctcgttg gtccagcaga 7260 ggcggccgcc cttgcgcgag cagaatggcg gtagggggtc tagctgcgtc tcgtccgggg 7320 ggtctgcgtc cacggtaaag accccgggca gcaggcgcgc gtcgaagtag tctatcttgc 7380 atccttgcaa gtctagcgcc tgctgccatg cgcgggcggc aagcgcgcgc tcgtatgggt 7440 tgagtggggg accccatggc atggggtggg tgagcgcgga ggcgtacatg ccgcaaatgt 7500 cgtaaacgta gaggggctct ctgagtattc caagatatgt agggtagcat cttccaccgc 7560 ggatgctggc gcgcacgtaa tcgtatagtt cgtgcgaggg agcgaggagg tcgggaccga 7620 ggttgctacg ggcgggctgc tctgctcgga agactatctg cctgaagatg gcatgtgagt 7680 tggatgatat ggttggacgc tggaagacgt tgaagctggc gtctgtgaga cctaccgcgt 7740 cacgcacgaa ggaggcgtag gagtcgcgca gcttgttgac cagctcggcg gtgacctgca 7800 cgtctagggc gcagtagtcc agggtttcct tgatgatgtc atacttatcc tgtccctttt 7860 ttttccacag ctcgcggttg aggacaaact cttcgcggtc tttccagtac tcttggatcg 7920 gaaacccgtc ggcctccgaa cggtaagagc ctagcatgta gaactggttg acggcctggt 7980 aggcgcagca tcccttttct acgggtagcg cgtatgcctg cgcggccttc cggagcgagg 8040 tgtgggtgag cgcaaaggtg tccctgacca tgactttgag gtactggtat ttgaagtcag 8100 tgtcgtcgca tccgccctgc tcccagagca aaaagtccgt gcgctttttg gaacgcggat 8160 ttggcagggc gaaggtgaca tcgttgaaga gtatctttcc cgcgcgaggc ataaagttgc 8220 gtgtgatgcg gaagggtccc ggcacctcgg aacggttgtt aattacctgg gcggcgagca 8280 cgatctcgtc aaagccgttg atgttgtggc ccacaatgta aagttccaag aagcgcggga 8340 tgcccttgat ggaaggcaat tttttaagtt cctcgtaggt gagctcttca ggggagctga 8400 gcccgtgctc tgaaagggcc cagtctgcaa gatgagggtt ggaagcgacg aatgagctcc 8460 acaggtcacg ggccattagc atttgcaggt ggtcgcgaaa ggtcctaaac tggcgaccta 8520 tggccatttt ttctggggtg atgcagtaga aggtaagcgg gtcttgttcc cagcggtccc 8580 atccaaggtt cgcggctagg tctcgcgcgg cagtcactag aggctcatct ccgccgaact 8640 tcatgaccag catgaagggc acgagctgct tcccaaaggc ccccatccaa gtataggtct 8700 ctacatcgta ggtgacaaag agacgctcgg tgcgaggatg cgagccgatc gggaagaact 8760 ggatctcccg ccaccaattg gaggagtggc tattgatgtg gtgaaagtag aagtccctgc 8820 gacgggccga acactcgtgc tggcttttgt aaaaacgtgc gcagtactgg cagcggtgca 8880 cgggctgtac atcctgcacg aggttgacct gacgaccgcg cacaaggaag cagagtggga 8940 atttgagccc ctcgcctggc gggtttggct ggtggtcttc tacttcggct gcttgtcctt 9000 gaccgtctgg ctgctcgagg ggagttacgg tggatcggac caccacgccg cgcgagccca 9060 aagtccagat gtccgcgcgc ggcggtcgga gcttgatgac aacatcgcgc agatgggagc 9120 tgtccatggt ctggagctcc cgcggcgtca ggtcaggcgg gagctcctgc aggtttacct 9180 cgcatagacg ggtcagggcg cgggctagat ccaggtgata cctaatttcc aggggctggt 9240 tggtggcggc gtcgatggct tgcaagaggc cgcatccccg cggcgcgact acggtaccgc 9300 gcggcgggcg gtgggccgcg ggggtgtcct tggatgatgc atctaaaagc ggtgacgcgg 9360 gcgagccccc ggaggtaggg ggggctccgg acccgccggg agagggggca ggggcacgtc 9420 ggcgccgcgc gcgggcagga gctggtgctg cgcgcgtagg ttgctggcga acgcgacgac 9480 gcggcggttg atctcctgaa tctggcgcct ctgcgtgaag acgacgggcc cggtgagctt 9540 gagcctgaaa gagagttcga cagaatcaat ttcggtgtcg ttgacggcgg cctggcgcaa 9600 aatctcctgc acgtctcctg agttgtcttg ataggcgatc tcggccatga actgctcgat 9660 ctcttcctcc tggagatctc cgcgtccggc tcgctccacg gtggcggcga ggtcgttgga 9720 aatgcgggcc atgagctgcg agaaggcgtt gaggcctccc tcgttccaga cgcggctgta 9780 gaccacgccc ccttcggcat cgcgggcgcg catgaccacc tgcgcgagat tgagctccac 9840 gtgccgggcg aagacggcgt agtttcgcag gcgctgaaag aggtagttga gggtggtggc 9900 ggtgtgttct gccacgaaga agtacataac ccagcgtcgc aacgtggatt cgttgatatc 9960 ccccaaggcc tcaaggcgct ccatggcctc gtagaagtcc acggcgaagt tgaaaaactg 10020 ggagttgcgc gccgacacgg ttaactcctc ctccagaaga cggatgagct cggcgacagt 10080 gtcgcgcacc tcgcgctcaa aggctacagg ggcctcttct tcttcttcaa tctcctcttc 10140 cataagggcc tccccttctt cttcttctgg cggcggtggg ggagggggga cacggcggcg 10200 acgacggcgc accgggaggc ggtcgacaaa gcgctcgatc atctccccgc ggcgacggcg 10260 catggtctcg gtgacggcgc ggccgttctc gcgggggcgc agttggaaga cgccgcccgt 10320 catgtcccgg ttatgggttg gcggggggct gccatgcggc agggatacgg cgctaacgat 10380 gcatctcaac aattgttgtg taggtactcc gccgccgagg gacctgagcg agtccgcatc 10440 gaccggatcg gaaaacctct cgagaaaggc gtctaaccag tcacagtcgc aaggtaggct 10500 gagcaccgtg gcgggcggca gcgggcggcg gtcggggttg tttctggcgg aggtgctgct 10560 gatgatgtaa ttaaagtagg cggtcttgag acggcggatg gtcgacagaa gcaccatgtc 10620 cttgggtccg gcctgctgaa tgcgcaggcg gtcggccatg ccccaggctt cgttttgaca 10680 tcggcgcagg tctttgtagt agtcttgcat gagcctttct accggcactt cttcttctcc 10740 ttcctcttgt cctgcatctc ttgcatctat cgctgcggcg gcggcggagt ttggccgtag 10800 gtggcgccct cttcctccca tgcgtgtgac cccgaagccc ctcatcggct gaagcagggc 10860 taggtcggcg acaacgcgct cggctaatat ggcctgctgc acctgcgtga gggtagactg 10920 gaagtcatcc atgtccacaa agcggtggta tgcgcccgtg ttgatggtgt aagtgcagtt 10980 ggccataacg gaccagttaa cggtctggtg acccggctgc gagagctcgg tgtacctgag 11040 acgcgagtaa gccctcgagt caaatacgta gtcgttgcaa gtccgcacca ggtactggta 11100 tcccaccaaa aagtgcggcg gcggctggcg gtagaggggc cagcgtaggg tggccggggc 11160 tccgggggcg agatcttcca acataaggcg atgatatccg tagatgtacc tggacatcca 11220 ggtgatgccg gcggcggtgg tggaggcgcg cggaaagtcg cggacgcggt tccagatgtt 11280 gcgcagcggc aaaaagtgct ccatggtcgg gacgctctgg ccggtcaggc gcgcgcaatc 11340 gttgacgctc tagaccgtgc aaaaggagag cctgtaagcg ggcactcttc cgtggtctgg 11400 tggataaatt cgcaagggta tcatggcgga cgaccggggt tcgagccccg tatccggccg 11460 tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc caggtgtgcg acgtcagaca 11520 acgggggagt gctccttttg gcttccttcc aggcgcggcg gctgctgcgc tagctttttt 11580 ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa gcgaaagcat taagtggctc 11640 gctccctgta gccggagggt tattttccaa gggttgagtc gcgggacccc cggttcgagt 11700 ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc ccgtcatgca agaccccgct 11760 tgcaaattcc tccggaaaca gggacgagcc ccttttttgc ttttcccaga tgcatccggt 11820 gctgcggcag atgcgccccc ctcctcagca gcggcaagag caagagcagc ggcagacatg 11880 cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg acatccgcgg ttgacgcggc 11940 agcagatggt gattacgaac ccccgcggcg ccgggcccgg cactacctgg acttggagga 12000 gggcgagggc ctggcgcggc taggagcgcc ctctcctgag cggtacccaa gggtgcagct 12060 gaagcgtgat acgcgtgagg cgtacgtgcc gcggcagaac ctgtttcgcg accgcgaggg 12120 agaggagccc gaggagatgc gggatcgaaa gttccacgca gggcgcgagc tgcggcatgg 12180 cctgaatcgc gagcggttgc tgcgcgagga ggactttgag cccgacgcgc gaaccgggat 12240 tagtcccgcg cgcgcacacg tggcggccgc cgacctggta accgcatacg agcagacggt 12300 gaaccaggag attaactttc aaaaaagctt taacaaccac gtgcgtacgc ttgtggcgcg 12360 cgaggaggtg gctataggac tgatgcatct gtgggacttt gtaagcgcgc tggagcaaaa 12420 cccaaatagc aagccgctca tggcgcagct gttccttata gtgcagcaca gcagggacaa 12480 cgaggcattc agggatgcgc tgctaaacat agtagagccc gagggccgct ggctgctcga 12540 tttgataaac atcctgcaga gcatagtggt gcaggagcgc agcttgagcc tggctgacaa 12600 ggtggccgcc atcaactatt ccatgcttag cctgggcaag ttttacgccc gcaagatata 12660 ccatacccct tacgttccca tagacaagga ggtaaagatc gaggggttct acatgcgcat 12720 ggcgctgaag gtgcttacct tgagcgacga cctgggcgtt tatcgcaacg agcgcatcca 12780 caaggccgtg agcgtgagcc ggcggcgcga gctcagcgac cgcgagctga tgcacagcct 12840 gcaaagggcc ctggctggca cgggcagcgg cgatagagag gccgagtcct actttgacgc 12900 gggcgctgac ctgcgctggg ccccaagccg acgcgccctg gaggcagctg gggccggacc 12960 tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc ggcgtggagg aatatgacga 13020 ggacgatgag tacgagccag aggacggcga gtactaagcg gtgatgtttc tgatcagatg 13080 atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc agagccagcc gtccggcctt 13140 aactccacgg acgactggcg ccaggtcatg gaccgcatca tgtcgctgac tgcgcgcaat 13200 cctgacgcgt tccggcagca gccgcaggcc aaccggctct ccgcaattct ggaagcggtg 13260 gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg cgatcgtaaa cgcgctggcc 13320 gaaaacaggg ccatccggcc cgacgaggcc ggcctggtct acgacgcgct gcttcagcgc 13380 gtggctcgtt acaacagcgg caacgtgcag accaacctgg accggctggt gggggatgtg 13440 cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg gcaacctggg ctccatggtt 13500 gcactaaacg ccttcctgag tacacagccc gccaacgtgc cgcggggaca ggaggactac 13560 accaactttg tgagcgcact gcggctaatg gtgactgaga caccgcaaag tgaggtgtac 13620 cagtctgggc cagactattt tttccagacc agtagacaag gcctgcagac cgtaaacctg 13680 agccaggctt tcaaaaactt gcaggggctg tggggggtgc gggctcccac aggcgaccgc 13740 gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt tgctgctgct aatagcgccc 13800 ttcacggaca gtggcagcgt gtcccgggac acatacctag gtcacttgct gacactgtac 13860 cgcgaggcca taggtcaggc gcatgtggac gagcatactt tccaggagat tacaagtgtc 13920 agccgcgcgc tggggcagga ggacacgggc agcctggagg caaccctaaa ctacctgctg 13980 accaaccggc ggcagaagat cccctcgttg cacagtttaa acagcgagga ggagcgcatt 14040 ttgcgctacg tgcagcagag cgtgagcctt aacctgatgc gcgacggggt aacgcccagc 14100 gtggcgctgg acatgaccgc gcgcaacatg gaaccgggca tgtatgcctc aaaccggccg 14160 tttatcaacc gcctaatgga ctacttgcat cgcgcggccg ccgtgaaccc cgagtatttc 14220 accaatgcca tcttgaaccc gcactggcta ccgccccctg gtttctacac cgggggattc 14280 gaggtgcccg agggtaacga tggattcctc tgggacgaca tagacgacag cgtgttttcc 14340 ccgcaaccgc agaccctgct agagttgcaa cagcgcgagc aggcagaggc ggcgctgcga 14400 aaggaaagct tccgcaggcc aagcagcttg tccgatctag gcgctgcggc cccgcggtca 14460 gatgctagta gcccatttcc aagcttgata gggtctctta ccagcactcg caccacccgc 14520 ccgcgcctgc tgggcgagga ggagtaccta aacaactcgc tgctgcagcc gcagcgcgaa 14580 aaaaacctgc ctccggcatt tcccaacaac gggatagaga gcctagtgga caagatgagt 14640 agatggaaga cgtacgcgca ggagcacagg gacgtgccag gcccgcgccc gcccacccgt 14700 cgtcaaaggc acgaccgtca gcggggtctg gtgtgggagg acgatgactc ggcagacgac 14760 agcagcgtcc tggatttggg agggagtggc aacccgtttg cgcaccttcg ccccaggctg 14820 gggagaatgt tttaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg 14880 gcaccgagcg ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg 14940 aaggtcctcc tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg 15000 gttctccctt cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta 15060 ccggggggag aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg 15120 tgtacctggt ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca 15180 gcaactttct gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac 15240 agaccatcaa tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata 15300 ccaacatgcc aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg 15360 tgtcgcgctt gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca 15420 cgctgcccga gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg 15480 tggagcacta cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa 15540 agtttgacac ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg 15600 gggtatatac aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg 15660 acttcaccca cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg 15720 agggctttag gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg 15780 tggacgccta ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg 15840 gcagcaacag cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc 15900 agccggtgga ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg 15960 aggagaagcg cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg 16020 aggtcgagaa gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac 16080 gcagttacaa cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg 16140 catacaacta cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg 16200 acgtaacctg cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg 16260 tgaccttccg ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc 16320 ccgtgcactc caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt 16380 ttacctctct gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc 16440 cagcccccac catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc 16500 taccgctgcg caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc 16560 gcacctgccc ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc 16620 gcactttttg agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc 16680 tgcgcttccc aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc 16740 gcgtgcgcgg gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca 16800 ccaccgtcga tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc 16860 cgccaccagt gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct 16920 atgctaaaat gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca 16980 ctgccgccca acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg 17040 cggccatgcg ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca 17100 ggcgacgagc ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg 17160 gcaacgtgta ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc 17220 ccccgcgcaa ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag 17280 cggcggcggc gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg 17340 tcatcgcgcc ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa 17400 agctaaagcg ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg 17460 aactgctgca cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac 17520 gtgttttgcg acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct 17580 acaagcgcgt gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc 17640 gcctcgggga gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg 17700 agggcaaccc aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg 17760 caccgtccga agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc 17820 agctgatggt acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac 17880 ctgggctgga gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg 17940 tgcagaccgt ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag 18000 agggcatgga gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg 18060 cggtcgctgc ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc 18120 gcgtttcagc cccccggcgc ccgcgcggtt cgaggaagta cggcgccgcc agcgcgctac 18180 tgcccgaata tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct 18240 accgccccag aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc 18300 gtcgccgtcg ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag 18360 gcaggaccct ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct 18420 ttgtggttct tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc 18480 gaggaagaat gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc 18540 gtgcgcacca ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc 18600 tccttattcc actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct 18660 tgcaggcgca gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt 18720 ctggactctc acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt 18780 gcgtctctgg ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc 18840 accagcaata tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat 18900 ttcggttcca ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg 18960 ctgagggata agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct 19020 ggcattagcg gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag 19080 cttgatcccc gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag 19140 gggcgtggcg aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac 19200 gagcctccct cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg 19260 cccatggcta ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc 19320 gccgacaccc agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct 19380 agccgcgcgt ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt 19440 ggcaactggc aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc 19500 cgacgatgct tctgaatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc 19560 gccagaggag ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga 19620 tgccgcagtg gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg 19680 ggctggtgca gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa 19740 accccacggt ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc 19800 ggttcatccc tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag 19860 ctgtgggtga taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc 19920 tggacagggg ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca 19980 agggtgcccc aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag 20040 aagaagagga cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc 20100 acgtatttgg gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag 20160 gtgtcgaagg tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag 20220 gagaatctca gtggtacgaa actgaaatta atcatgcagc tgggagagtc cttaaaaaga 20280 ctaccccaat gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc 20340 aaggcattct tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt 20400 tctcaactac tgaggcgacc gcaggcaatg gtgataactt gactcctaaa gtggtattgt 20460 acagtgaaga tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta 20520 aggaaggtaa ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca 20580 ttgcttttag ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg 20640 ttctggcggg ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag 20700 agctttcata ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt 20760 ggaatcaggc tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg 20820 aagatgaact tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta 20880 ccaaggtaaa acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt 20940 cagataaaaa tgaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca 21000 acctgtggag aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt 21060 acagtccttc caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc 21120 gagtggtggc tcccgggtta gtggactgct acattaacct tggagcacgc tggtcccttg 21180 actatatgga caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct 21240 caatgttgct gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct 21300 ttgccattaa aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga 21360 aggatgttaa catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca 21420 gcattaagtt tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg 21480 cctccacgct tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc 21540 tctccgccgc caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca 21600 tcccctcccg caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg 21660 aaaccccatc actgggctcg ggctacgacc cttattacac ctactctggc tctataccct 21720 acctagatgg aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact 21780 cttctgtcag ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc 21840 gctcagttga cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc 21900 tggtacaaat gctagctaac tacaacattg gctaccaggg cttctatatc ccagagagct 21960 acaaggaccg catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg 22020 atgatactaa atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg 22080 gatttgttgg ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc 22140 cctatccgct tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg 22200 atcgcaccct ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag 22260 acctgggcca aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg 22320 tggatcccat ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc 22380 gtgtgcaccg gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg 22440 ccggcaacgc cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc 22500 cagtgagcag gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg 22560 cacctatgac aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt 22620 caatacggcc ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca 22680 ctcaaaaaca tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt 22740 ttaccagttt gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg 22800 ctgtataacg ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg 22860 actattctgc tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca 22920 caaccccacc atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt 22980 acagcccacc ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc 23040 ctacttccgc agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa 23100 catgtaaaaa taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac 23160 tctcgggtga ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt 23220 ctgccgcgca tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct 23280 ccacttaaac tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct 23340 gcgcaccatc accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg 23400 gcctccgccc tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag 23460 cgccgggtgg tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc 23520 ctccgcgttg ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc 23580 gtgcccaggc tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt 23640 ctgggcgtta ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc 23700 ctttgcgcct tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca 23760 ggccgcgtcg tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc 23820 ccaccggttc ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt 23880 ttcgctcgtc acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag 23940 acacttaagc tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg 24000 ctcgtgatgc ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc 24060 catcatcgtc acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc 24120 gttcagccag gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa 24180 gttcgccttt agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat 24240 gcccttctcc cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact 24300 ttccgcttcg ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc 24360 gtcttcattc agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg 24420 tgggttgctg aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac 24480 gattacctct ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt 24540 gggcgcaatg gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac 24600 cagcgcgtct tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt 24660 ttttgggggc gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt 24720 tgggggacgt cgcgccgcac cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc 24780 ccgactggcc atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa 24840 ggacagccta accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc 24900 gcctaccacc ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca 24960 ggacccaggt tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa 25020 gcaagaccag gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca 25080 tggcgactac ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc 25140 cattatctgc gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag 25200 ccttgcctac gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg 25260 cacatgcgag cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct 25320 tgccacctat cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg 25380 cagccgagcg gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc 25440 gctcaacgaa gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa 25500 cgctctgcaa caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga 25560 gggtgacaac gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta 25620 cccggcactt aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg 25680 ccgtgcgcag cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc 25740 cgcagttggc gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga 25800 ggagcgacgc aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca 25860 gcggttcttt gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt 25920 tcgacagggc tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt 25980 ctcctacctt ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct 26040 caagggcgag gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac 26100 ctggcagacg gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct 26160 gcagaaactg ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt 26220 ggccgcgcac ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg 26280 tctgccagac ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg 26340 ctcaggaatc ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta 26400 ccgcgaatgc cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct 26460 tgcctaccac tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg 26520 tcgctgcaac ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga 26580 aagtcaaatt atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc 26640 tccggggttg aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc 26700 tgaggactac cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccaaatgc 26760 ggagcttacc gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa 26820 caaagcccgc caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc 26880 cggcgaggag ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc 26940 ccttgcttcc caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg 27000 aggaggaata ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga 27060 tggaagactg ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa 27120 caccgtcacc ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca 27180 gcatggctac aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc 27240 gtagatggga caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc 27300 aagagcaaca acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg 27360 cttgcttgca agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc 27420 acggcgtggc cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact 27480 gcaccggcgg cagcggcagc ggcagcaaca gcagcggcca cacagaagca aaggcgaccg 27540 gatagcaaga ctctgacaaa gcccaagaaa tccacagcgg cggcagcagc aggaggagga 27600 gcgctgcgtc tggcgcccaa cgaacccgta tcgacccgcg agcttagaaa caggattttt 27660 cccactctgt atgctatatt tcaacagagc aggggccaag aacaagagct gaaaataaaa 27720 aacaggtctc tgcgatccct cacccgcagc tgcctgtatc acaaaagcga agatcagctt 27780 cggcgcacgc tggaagacgc ggaggctctc ttcagtaaat actgcgcgct gactcttaag 27840 gactagtttc gcgccctttc tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca 27900 cacccggcgc cagcacctgt cgtcagcgcc atttcaactt tgtatacaaa agttgtgatg 27960 agcaaggaaa ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct 28020 ggagctgccc aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata 28080 tcccgggtca acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt 28140 accaccacac ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag 28200 gaaagtcccg ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg 28260 actaactcag gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag 28320 ggtataactc acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc 28380 tcctcgcttg gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca 28440 ttcacgcctc gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga 28500 ggcattggaa ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc 28560 tcgggacctc ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac 28620 tcggcggacg gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac 28680 ctggtccact gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt 28740 gaattgcccg aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga 28800 gagcttgccc gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac 28860 aggggaccct gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat 28920 ctttgttgcc atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc 28980 ctatcgccat cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt 29040 acctggtact tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt 29100 gagtctacga gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct 29160 tacctgccgg gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg 29220 taaaccagac tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc 29280 ttagaaaacc cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt 29340 caagcaactc tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc 29400 tctgtcttgt gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct 29460 gctgtgtgca catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat 29520 gattaggtac ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa 29580 ggtggatttt aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac 29640 cactcttata aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat 29700 tggcaagtat gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac 29760 agttttccag ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg 29820 cgacattacc atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga 29880 aaacactggc actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac 29940 cctactctat attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta 30000 atttactaag ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca 30060 aattcaaaaa gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct 30120 caataccatt cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg 30180 aagtcaggct tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt 30240 tccagtccaa ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc 30300 cgctaccgga cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg 30360 ggataacttg ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat 30420 gtggctcatc tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat 30480 tgtgctacac ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt 30540 ttctcttaca gtatgattaa atgagacatg gccgttcagc tggtggaaag tggcgggggt 30600 tctgttcagg cgggcgggtc tctgaggctt acttgcgccg cgagtggtag aaccagtcgg 30660 agctacggaa tggggtggtt taggcaagct cccgggaaag aacgcgaatt tgtgagcggc 30720 attagctggc ggggcgattc cactgggtac gcagactctg taaagggaag gtttaccatc 30780 agccgcgata acgcaaagaa caccgttgat ctgcagatga atagcttgag accggaggac 30840 accgccatct actactgtgc agctgccgcc ggaagcacat ggtatgggac tctgtatgaa 30900 tacgactact ggggccaggg tacacaagtt accgtaagca gcggctctgg gtccggctcg 30960 accggagtgc aggtggaaac catctcccca ggagacgggc gcaccttccc caagcgcggc 31020 cagacctgcg tggtgcacta caccgggatg cttgaagatg gaaagaaatt tgattcctcc 31080 cgggacagaa acaagccctt taagtttatg ctaggcaagc aggaggtgat ccgaggctgg 31140 gaagaagggg ttgcccagat gagtgtgggt cagagagcca aactgactat atctccagat 31200 tatgcctatg gtgccactgg gcacccaggc atcatcccac cacatgccac tctcgtcttc 31260 gatgtggagc ttctaaaact gtaataaaaa aaaataataa agcatcactt acttaaaatc 31320 agttagcaaa tttctgtcca gtttattcag cagcacctcc ttgccctcct cccagctctg 31380 gtattgcagc ttcctcctgg ctgcaaactt tctccacaat ctaaatggaa tgtcagtttc 31440 ctcctgttcc tgtccatccg cacccactat cttcatgttg ttgcagatga agcgcgcaag 31500 accgtctgaa gataccttca accccgtgta tccatatgac acggaaaccg gtcctccaac 31560 tgtgcctttt cttactcctc cctttgtatc ccccaatggg tttcaagaga gtccccctgg 31620 ggtactctct ttgcgcctat ccgaacctct agttacctcc aatggcatgc ttgcgctcaa 31680 aatgggcaac ggcctctctc tggacgaggc cggcaacctt acctcccaaa atgtaaccac 31740 tgtgagccca cctctcaaaa aaaccaagtc aaacataaac ctggaaatat ctgcacccct 31800 cacagttacc tcagaagccc taactgtggc tgccgccgca cctctaatgg tcgcgggcaa 31860 cacactcacc atgcaatcac aggccccgct aaccgtgcac gactccaaac ttagcattgc 31920 cacccaagga cccctcacag tgtcagaagg aaagctagcc ctgcaaacat caggccccct 31980 caccaccacc gatagcagta cccttactat cactgcctca ccccctctaa ctactgccac 32040 tggtagcttg ggcattgact tgaaagagcc catttataca caaaatggaa aactaggact 32100 aaagtacggg gctcctttgc atgtaacaga cgacctaaac actttgaccg tagcaactgg 32160 tccaggtgtg actattaata atacttcctt gcaaactaaa gttactggag ccttgggttt 32220 tgattcacaa ggcaatatgc aacttaatgt agcaggagga ctaaggattg attctcaaaa 32280 cagacgcctt atacttgatg ttagttatcc gtttgatgct caaaaccaac taaatctaag 32340 actaggacag ggccctcttt ttataaactc agcccacaac ttggatatta actacaacaa 32400 aggcctttac ttgtttacag cttcaaacaa ttccaaaaag cttgaggtta acctaagcac 32460 tgccaagggg ttgatgtttg acgctacagc catagccatt aatgcaggag atgggcttga 32520 atttggttca cctaatgcac caaacacaaa tcccctcaaa acaaaaattg gccatggcct 32580 agaatttgat tcaaacaagg ctatggttcc taaactagga actggcctta gttttgacag 32640 cacaggtgcc attacagtag gaaacaaaaa taatgataag ctaactttgt ggaccacacc 32700 agctccatct cctaactgta gactaaatgc agagaaagat gctaaactca ctttggtctt 32760 aacaaaatgt ggcagtcaaa tacttgctac agtttcagtt ttggctgtta aaggcagttt 32820 ggctccaata tctggaacag ttcaaagtgc tcatcttatt ataagatttg acgaaaatgg 32880 agtgctacta aacaattcct tcctggaccc agaatattgg aactttagaa atggagatct 32940 tactgaaggc acagcctata caaacgctgt tggatttatg cctaacctat cagcttatcc 33000 aaaatctcac ggtaaaactg ccaaaagtaa cattgtcagt caagtttact taaacggaga 33060 caaaactaaa cctgtaacac taaccattac actaaacggt acacaggaaa caggagacac 33120 aactccaagt gcatactcta tgtcattttc atgggactgg tctggccaca actacattaa 33180 tgaaatattt gccacatcct cttacacttt ttcatacatt gcccaagaat aaagaatcgt 33240 ttgtgttatg tttcaacgtg tttatttttc aattgcagaa aatttcaagt catttttcat 33300 tcagtagtat agccccacca ccacatagct tatacagatc accgtacctc aactttgtat 33360 aataaagttg taatcaaact cacagaaccc tagtattcaa cctgccacct ccctcccaac 33420 acacagagta cacagtcctt tctccccggc tggccttaaa aagcatcata tcatgggtaa 33480 cagacatatt cttaggtgtt atattccaca cggtttcctg tcgagccaaa cgctcatcag 33540 tgatattaat aaactccccg ggcagctcac ttaagttcat gtcgctgtcc agctgctgag 33600 ccacaggctg ctgtccaact tgcggttgct taacgggcgg cgaaggagaa gtccacgcct 33660 acatgggggt agagtcataa tcgtgcatca ggatagggcg gtggtgctgc agcagcgcgc 33720 gaataaactg ctgccgccgc cgctccgtcc tgcaggaata caacatggca gtggtctcct 33780 cagcgatgat tcgcaccgcc cgcagcataa ggcgccttgt cctccgggca cagcagcgca 33840 ccctgatctc acttaaatca gcacagtaac tgcagcacag caccacaata ttgttcaaaa 33900 tcccacagtg caaggcgctg tatccaaagc tcatggcggg gaccacagaa cccacgtggc 33960 catcatacca caagcgcagg tagattaagt ggcgacccct cataaacacg ctggacataa 34020 acattacctc ttttggcatg ttgtaattca ccacctcccg gtaccatata aacctctgat 34080 taaacatggc gccatccacc accatcctaa accagctggc caaaacctgc ccgccggcta 34140 tacactgcag ggaaccggga ctggaacaat gacagtggag agcccaggac tcgtaaccat 34200 ggatcatcat gctcgtcatg atatcaatgt tggcacaaca caggcacacg tgcatacact 34260 tcctcaggat tacaagctcc tcccgcgtta gaaccatatc ccagggaaca acccattcct 34320 gaatcagcgt aaatcccaca ctgcagggaa gacctcgcac gtaactcacg ttgtgcattg 34380 tcaaagtgtt acattcgggc agcagcggat gatcctccag tatggtagcg cgggtttctg 34440 tctcaaaagg aggtagacga tccctactgt acggagtgcg ccgagacaac cgagatcgtg 34500 ttggtcgtag tgtcatgcca aatggaacgc cggacgtagt catatttcct gaagcaaaac 34560 caggtgcggg cgtgacaaac agatctgcgt ctccggtctc gccgcttaga tcgctctgtg 34620 tagtagttgt agtatatcca ctctctcaaa gcatccaggc gccccctggc ttcgggttct 34680 atgtaaactc cttcatgcgc cgctgccctg ataacatcca ccaccgcaga ataagccaca 34740 cccagccaac ctacacattc gttctgcgag tcacacacgg gaggagcggg aagagctgga 34800 agaaccatgt tttttttttt attccaaaag attatccaaa acctcaaaat gaagatctat 34860 taagtgaacg cgctcccctc cggtggcgtg gtcaaactct acagccaaag aacagataat 34920 ggcatttgta agatgttgca caatggcttc caaaaggcaa acggccctca cgtccaagtg 34980 gacgtaaagg ctaaaccctt cagggtgaat ctcctctata aacattccag caccttcaac 35040 catgcccaaa taattctcat ctcgccacct tctcaatata tctctaagca aatcccgaat 35100 attaagtccg gccattgtaa aaatctgctc cagagcgccc tccaccttca gcctcaagca 35160 gcgaatcatg attgcaaaaa ttcaggttcc tcacagacct gtataagatt caaaagcgga 35220 acattaacaa aaataccgcg atcccgtagg tcccttcgca gggccagctg aacataatcg 35280 tgcaggtctg cacggaccag cgcggccact tccccgccag gaaccatgac aaaagaaccc 35340 acactgatta tgacacgcat actcggagct atgctaacca gcgtagcccc gatgtaagct 35400 tgttgcatgg gcggcgatat aaaatgcaag gtgctgctca aaaaatcagg caaagcctcg 35460 cgcaaaaaag aaagcacatc gtagtcatgc tcatgcagat aaaggcaggt aagctccgga 35520 accaccacag aaaaagacac catttttctc tcaaacatgt ctgcgggttt ctgcataaac 35580 acaaaataaa ataacaaaaa aacatttaaa cattagaagc ctgtcttaca acaggaaaaa 35640 caacccttat aagcataaga cggactacgg ccatgccggc gtgaccgtaa aaaaactggt 35700 caccgtgatt aaaaagcacc accgacagct cctcggtcat gtccggagtc ataatgtaag 35760 actcggtaaa cacatcaggt tgattcacat cggtcagtgc taaaaagcga ccgaaatagc 35820 ccgggggaat acatacccgc aggcgtagag acaacattac agcccccata ggaggtataa 35880 caaaattaat aggagagaaa aacacataaa cacctgaaaa accctcctgc ctaggcaaaa 35940 tagcaccctc ccgctccaga acaacataca gcgcttccac agcggcagcc ataacagtca 36000 gccttaccag taaaaaagaa aacctattaa aaaaacacca ctcgacacgg caccagctca 36060 atcagtcaca gtgtaaaaaa gggccaagtg cagagcgagt atatatagga ctaaaaaatg 36120 acgtaacggt taaagtccac aaaaaacacc cagaaaaccg cacgcgaacc tacgcccaga 36180 aacgaaagcc aaaaaaccca caacttcctc aaatcgtcac ttccgttttc ccacgttacg 36240 tcacttccca ttttaagaaa actacaattc ccaacacata caagttactc cgccctaaaa 36300 cctacgtcac ccgccccgtt cccacgcccc gcgccacgtc acaaactcca ccccctcatt 36360 atcatattgg cttcaatcca aaataaggta tattattgat gatg 36404 <210> 90 <211> 37013 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO207) <400> 90 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc 600 catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg 660 cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct 720 gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg 780 ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt 840 ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa 900 gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga 960 cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat 1020 ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga 1080 cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt 1140 gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga 1200 gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat 1260 ggacgagctg tacaagggaa gtggacggga gggaatgaga catattatct gccacggagg 1320 tgttattacc gaagaaatgg ccgccagtct tttggaccag ctgatcgaag aggtactggc 1380 tgataatctt ccacctccta gccattttga accacctacc cttcacgaac tgtatgattt 1440 agacgtgacg gcccccgaag atcccaacga ggaggcggtt tcgcagattt ttcccgactc 1500 tgtaatgttg gcggtgcagg aagggattga cttactcact tttccgccgg cgcccggttc 1560 tccggagccg cctcaccttt cccggcagcc cgagcagccg gagcagagag ccttgggtcc 1620 ggtttctatg ccaaaccttg taccggaggt gatcgatctt acctgccacg aggctggctt 1680 tccacccagt gacgacgagg atgaagaggg tgaggagttt gtgttagatt atgtggagca 1740 ccccgggcac ggttgcaggt cttgtcatta tcaccggagg aatacggggg acccagatat 1800 tatgtgttcg ctttgctata tgaggacctg tggcatgttt gtctacagta agtgaaaatt 1860 atgggcagtg ggtgatagag tggtgggttt ggtgtggtaa tttttttttt aatttttaca 1920 gttttgtggt ttaaagaatt ttgtattgtg atttttttaa aaggtcctgt gtctgaacct 1980 gagcctgagc ccgagccaga accggagcct gcaagaccta cccgccgtcc taaaatggcg 2040 cctgctatcc tgagacgccc gacatcacct gtgtctagag aatgcaatag tagtacggat 2100 agctgtgact ccggtccttc taacacacct cctgagatac acccggtggt cccgctgtgc 2160 cccattaaac cagttgccgt gagagttggt gggcgtcgcc aggctgtgga atgtatcgag 2220 gacttgctta acgagcctgg gcaacctttg gacttgagct gtaaacgccc caggccataa 2280 ggtgtaaacc tgtgattgcg tgtgtggtta acgcctttgt ttgctgaatg agttgatgta 2340 agtttaataa agggtgagat aatgtttaac ttgcatggcg tgttaaatgg ggcggggctt 2400 aaagggtata taatgcgccg tgggctaatc ttggttacat ctgacctcat ggaggcttgg 2460 gagtgtttgg aagatttttc tgctgtgcgt aacttgctgg aacagagctc taacagtacc 2520 tcttggtttt ggaggtttct gtggggctca tcccaggcaa agttagtctg cagaattaag 2580 gaggattaca agtgggaatt tgaagagctt ttgaaatcct gtggtgagct gtttgattct 2640 ttgaatctgg gtcaccaggc gcttttccaa gagaaggtca tcaagacttt ggatttttcc 2700 acaccggggc gcgctgcggc tgctgttgct tttttgagtt ttataaagga taaatggagc 2760 gaagaaaccc atctgagcgg ggggtacctg ctggattttc tggccatgca tctgtggaga 2820 gcggttgtga gacacaagaa tcgcctgcta ctgttgtctt ccgtccgccc ggcgataata 2880 ccgacggagg agcagcagca gcagcaggag gaagccaggc ggcggcggca ggagcagagc 2940 ccatggaacc cgagagccgg cctggaccct cgggaatgaa tgttgtacag gtggctgaac 3000 tgtatccaga actgagacgc attttgacaa ttacagagga tgggcagggg ctaaaggggg 3060 taaagaggga gcggggggct tgtgaggcta cagaggaggc taggaatcta gcttttagct 3120 taatgaccag acaccgtcct gagtgtatta cttttcaaca gatcaaggat aattgcgcta 3180 atgagcttga tctgctggcg cagaagtatt ccatagagca gctgaccact tactggctgc 3240 agccagggga tgattttgag gaggctatta gggtatatgc aaaggtggca cttaggccag 3300 attgcaagta caagatcagc aaacttgtaa atatcaggaa ttgttgctac atttctggga 3360 acggggccga ggtggagata gatacggagg atagggtggc ctttagatgt agcatgataa 3420 atatgtggcc gggggtgctt ggcatggacg gggtggttat tatgaatgta aggtttactg 3480 gccccaattt tagcggtacg gttttcctgg ccaataccaa ccttatccta cacggtgtaa 3540 gcttctatgg gtttaacaat acctgtgtgg aagcctggac cgatgtaagg gttcggggct 3600 gtgcctttta ctgctgctgg aagggggtgg tgtgtcgccc caaaagcagg gcttcaatta 3660 agaaatgcct ctttgaaagg tgtaccttgg gtatcctgtc tgagggtaac tccagggtgc 3720 gccacaatgt ggcctccgac tgtggttgct tcatgctagt gaaaagcgtg gctgtgatta 3780 agcataacat ggtatgtggc aactgcgagg acagggcctc tcagatgctg acctgctcgg 3840 acggcaactg tcacctgctg aagaccattc acgtagccag ccactctcgc aaggcctggc 3900 cagtgtttga gcataacata ctgacccgct gttccttgca tttgggtaac aggagggggg 3960 tgttcctacc ttaccaatgc aatttgagtc acactaagat attgcttgag cccgagagca 4020 tgtccaaggt gaacctgaac ggggtgtttg acatgaccat gaagatctgg aaggtgctga 4080 ggtacgatga gacccgcacc aggtgcagac cctgcgagtg tggcggtaaa catattagga 4140 accagcctgt gatgctggat gtgaccgagg agctgaggcc cgatcacttg gtgctggcct 4200 gcacccgcgc tgagtttggc tctagcgatg aagatacaga ttgaggtact gaaatgtgtg 4260 ggcgtggctt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct 4320 gttttgcagc agccgccgcc gcccaacttt tctatacaaa gttgtaatga gcaccaactc 4380 gtttgatgga agcattgtga gctcatattt gacaacgcgc atgcccccat gggccggggt 4440 gcgtcagaat gtgatgggct ccagcattga tggtcgcccc gtcctgcccg caaactctac 4500 taccttgacc tacgagaccg tgtctggaac gccgttggag actgcagcct ccgccgccgc 4560 ttcagccgct gcagccaccg cccgcgggat tgtgactgac tttgctttcc tgagcccgct 4620 tgcaagcagt gcagcttccc gttcatccgc ccgcgatgac aagttgacgg ctcttttggc 4680 acaattggat tctttgaccc gggaacttaa tgtcgtttct cagcagctgt tggatctgcg 4740 ccagcaggtt tctgccctga aggcttcctc ccctcccaat gcggtttaaa acataaataa 4800 aaaaccagac tctgtttgga tttggatcaa gcataagtgt cttgctgtct ttatttaggg 4860 gttttgcgcg cgcggtaggc ccgggaccag cggtctcggt cgttgagggt cctgtgtatt 4920 ttttccagga cgtggtaaag gtgactctgg atgttcagat acatgggcat aagcccgtct 4980 ctggggtgga ggtagcacca ctgcagagct tcatgctgcg gggtggtgtt gtagatgatc 5040 cagtcgtagc aggagcgctg ggcgtggtgc ctaaaaatgt ctttcagtag caagctgatt 5100 gccaggggca ggcccttggt gtaagtgttt acaaagcggt taagctggga tgggtgcata 5160 cgtggggata tgagatgcat cttggactgt atttttaggt tggctatgtt cccagccata 5220 tccctccggg gattcatgtt gtgcagaacc accagcacag tgtatccggt gcacttggga 5280 aatttgtcat gtagcttaga aggaaatgcg tggaagaact tggagacgcc cttgtgacct 5340 ccaagatttt ccatgcattc gtccataatg atggcaatgg gcccacgggc ggcggcctgg 5400 gcgaagatat ttctgggatc actaacgtca tagttgtgtt ccaggatgag atcgtcatag 5460 gccattttta caaagcgcgg gcggagggtg ccagactgcg gtataatggt tccatccggc 5520 ccaggggcgt agttaccctc acagatttgc atttcccacg ctttgagttc agatgggggg 5580 atcatgtcta cctgcggggc gatgaagaaa acggtttccg gggtagggga gatcagctgg 5640 gaagaaagca ggttcctgag cagctgcgac ttaccgcagc cggtgggccc gtaaatcaca 5700 cctattaccg ggtgcaactg gtagttaaga gagctgcagc tgccgtcatc cctgagcagg 5760 ggggccactt cgttaagcat gtccctgact cgcatgtttt ccctgaccaa atccgccaga 5820 aggcgctcgc cgcccagcga tagcagttct tgcaaggaag caaagttttt caacggtttg 5880 agaccgtccg ccgtaggcat gcttttgagc gtttgaccaa gcagttccag gcggtcccac 5940 agctcggtca cctgctctac ggcatctcga tccagcatat ctcctcgttt cgcgggttgg 6000 ggcggctttc gctgtacggc agtagtcggt gctcgtccag acgggccagg gtcatgtctt 6060 tccacgggcg cagggtcctc gtcagcgtag tctgggtcac ggtgaagggg tgcgctccgg 6120 gctgcgcgct ggccagggtg cgcttgaggc tggtcctgct ggtgctgaag cgctgccggt 6180 cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt gtcatagtcc agcccctccg 6240 cggcgtggcc cttggcgcgc agcttgccct tggaggaggc gccgcacgag gggcagtgca 6300 gacttttgag ggcgtagagc ttgggcgcga gaaataccga ttccggggag taggcatccg 6360 cgccgcaggc cccgcagacg gtctcgcatt ccacgagcca ggtgagctct ggccgttcgg 6420 ggtcaaaaac caggtttccc ccatgctttt tgatgcgttt cttacctctg gtttccatga 6480 gccggtgtcc acgctcggtg acgaaaaggc tgtccgtgtc cccgtataca gacttgagag 6540 gcctgtcctc gagcggtgtt ccgcggtcct cctcgtatag aaactcggac cactctgaga 6600 caaaggctcg cgtccaggcc agcacgaagg aggctaagtg ggaggggtag cggtcgttgt 6660 ccactagggg gtccactcgc tccagggtgt gaagacacat gtcgccctct tcggcatcaa 6720 ggaaggtgat tggtttgtag gtgtaggcca cgtgaccggg tgttcctgaa ggggggctat 6780 aaaagggggt gggggcgcgt tcgtcctcac tctcttccgc atcgctgtct gcgagggcca 6840 gctgttgggg tgagtactcc ctctgaaaag cgggcatgac ttctgcgcta agattgtcag 6900 tttccaaaaa cgaggaggat ttgatattca cctggcccgc ggtgatgcct ttgagggtgg 6960 ccgcatccat ctggtcagaa aagacaatct ttttgttgtc aagcttggtg gcaaacgacc 7020 cgtagagggc gttggacagc aacttggcga tggagcgcag ggtttggttt ttgtcgcgat 7080 cggcgcgctc cttggccgcg atgtttagct gcacgtattc gcgcgcaacg caccgccatt 7140 cgggaaagac ggtggtgcgc tcgtcgggca ccaggtgcac gcgccaaccg cggttgtgca 7200 gggtgacaag gtcaacgctg gtggctacct ctccgcgtag gcgctcgttg gtccagcaga 7260 ggcggccgcc cttgcgcgag cagaatggcg gtagggggtc tagctgcgtc tcgtccgggg 7320 ggtctgcgtc cacggtaaag accccgggca gcaggcgcgc gtcgaagtag tctatcttgc 7380 atccttgcaa gtctagcgcc tgctgccatg cgcgggcggc aagcgcgcgc tcgtatgggt 7440 tgagtggggg accccatggc atggggtggg tgagcgcgga ggcgtacatg ccgcaaatgt 7500 cgtaaacgta gaggggctct ctgagtattc caagatatgt agggtagcat cttccaccgc 7560 ggatgctggc gcgcacgtaa tcgtatagtt cgtgcgaggg agcgaggagg tcgggaccga 7620 ggttgctacg ggcgggctgc tctgctcgga agactatctg cctgaagatg gcatgtgagt 7680 tggatgatat ggttggacgc tggaagacgt tgaagctggc gtctgtgaga cctaccgcgt 7740 cacgcacgaa ggaggcgtag gagtcgcgca gcttgttgac cagctcggcg gtgacctgca 7800 cgtctagggc gcagtagtcc agggtttcct tgatgatgtc atacttatcc tgtccctttt 7860 ttttccacag ctcgcggttg aggacaaact cttcgcggtc tttccagtac tcttggatcg 7920 gaaacccgtc ggcctccgaa cggtaagagc ctagcatgta gaactggttg acggcctggt 7980 aggcgcagca tcccttttct acgggtagcg cgtatgcctg cgcggccttc cggagcgagg 8040 tgtgggtgag cgcaaaggtg tccctgacca tgactttgag gtactggtat ttgaagtcag 8100 tgtcgtcgca tccgccctgc tcccagagca aaaagtccgt gcgctttttg gaacgcggat 8160 ttggcagggc gaaggtgaca tcgttgaaga gtatctttcc cgcgcgaggc ataaagttgc 8220 gtgtgatgcg gaagggtccc ggcacctcgg aacggttgtt aattacctgg gcggcgagca 8280 cgatctcgtc aaagccgttg atgttgtggc ccacaatgta aagttccaag aagcgcggga 8340 tgcccttgat ggaaggcaat tttttaagtt cctcgtaggt gagctcttca ggggagctga 8400 gcccgtgctc tgaaagggcc cagtctgcaa gatgagggtt ggaagcgacg aatgagctcc 8460 acaggtcacg ggccattagc atttgcaggt ggtcgcgaaa ggtcctaaac tggcgaccta 8520 tggccatttt ttctggggtg atgcagtaga aggtaagcgg gtcttgttcc cagcggtccc 8580 atccaaggtt cgcggctagg tctcgcgcgg cagtcactag aggctcatct ccgccgaact 8640 tcatgaccag catgaagggc acgagctgct tcccaaaggc ccccatccaa gtataggtct 8700 ctacatcgta ggtgacaaag agacgctcgg tgcgaggatg cgagccgatc gggaagaact 8760 ggatctcccg ccaccaattg gaggagtggc tattgatgtg gtgaaagtag aagtccctgc 8820 gacgggccga acactcgtgc tggcttttgt aaaaacgtgc gcagtactgg cagcggtgca 8880 cgggctgtac atcctgcacg aggttgacct gacgaccgcg cacaaggaag cagagtggga 8940 atttgagccc ctcgcctggc gggtttggct ggtggtcttc tacttcggct gcttgtcctt 9000 gaccgtctgg ctgctcgagg ggagttacgg tggatcggac caccacgccg cgcgagccca 9060 aagtccagat gtccgcgcgc ggcggtcgga gcttgatgac aacatcgcgc agatgggagc 9120 tgtccatggt ctggagctcc cgcggcgtca ggtcaggcgg gagctcctgc aggtttacct 9180 cgcatagacg ggtcagggcg cgggctagat ccaggtgata cctaatttcc aggggctggt 9240 tggtggcggc gtcgatggct tgcaagaggc cgcatccccg cggcgcgact acggtaccgc 9300 gcggcgggcg gtgggccgcg ggggtgtcct tggatgatgc atctaaaagc ggtgacgcgg 9360 gcgagccccc ggaggtaggg ggggctccgg acccgccggg agagggggca ggggcacgtc 9420 ggcgccgcgc gcgggcagga gctggtgctg cgcgcgtagg ttgctggcga acgcgacgac 9480 gcggcggttg atctcctgaa tctggcgcct ctgcgtgaag acgacgggcc cggtgagctt 9540 gagcctgaaa gagagttcga cagaatcaat ttcggtgtcg ttgacggcgg cctggcgcaa 9600 aatctcctgc acgtctcctg agttgtcttg ataggcgatc tcggccatga actgctcgat 9660 ctcttcctcc tggagatctc cgcgtccggc tcgctccacg gtggcggcga ggtcgttgga 9720 aatgcgggcc atgagctgcg agaaggcgtt gaggcctccc tcgttccaga cgcggctgta 9780 gaccacgccc ccttcggcat cgcgggcgcg catgaccacc tgcgcgagat tgagctccac 9840 gtgccgggcg aagacggcgt agtttcgcag gcgctgaaag aggtagttga gggtggtggc 9900 ggtgtgttct gccacgaaga agtacataac ccagcgtcgc aacgtggatt cgttgatatc 9960 ccccaaggcc tcaaggcgct ccatggcctc gtagaagtcc acggcgaagt tgaaaaactg 10020 ggagttgcgc gccgacacgg ttaactcctc ctccagaaga cggatgagct cggcgacagt 10080 gtcgcgcacc tcgcgctcaa aggctacagg ggcctcttct tcttcttcaa tctcctcttc 10140 cataagggcc tccccttctt cttcttctgg cggcggtggg ggagggggga cacggcggcg 10200 acgacggcgc accgggaggc ggtcgacaaa gcgctcgatc atctccccgc ggcgacggcg 10260 catggtctcg gtgacggcgc ggccgttctc gcgggggcgc agttggaaga cgccgcccgt 10320 catgtcccgg ttatgggttg gcggggggct gccatgcggc agggatacgg cgctaacgat 10380 gcatctcaac aattgttgtg taggtactcc gccgccgagg gacctgagcg agtccgcatc 10440 gaccggatcg gaaaacctct cgagaaaggc gtctaaccag tcacagtcgc aaggtaggct 10500 gagcaccgtg gcgggcggca gcgggcggcg gtcggggttg tttctggcgg aggtgctgct 10560 gatgatgtaa ttaaagtagg cggtcttgag acggcggatg gtcgacagaa gcaccatgtc 10620 cttgggtccg gcctgctgaa tgcgcaggcg gtcggccatg ccccaggctt cgttttgaca 10680 tcggcgcagg tctttgtagt agtcttgcat gagcctttct accggcactt cttcttctcc 10740 ttcctcttgt cctgcatctc ttgcatctat cgctgcggcg gcggcggagt ttggccgtag 10800 gtggcgccct cttcctccca tgcgtgtgac cccgaagccc ctcatcggct gaagcagggc 10860 taggtcggcg acaacgcgct cggctaatat ggcctgctgc acctgcgtga gggtagactg 10920 gaagtcatcc atgtccacaa agcggtggta tgcgcccgtg ttgatggtgt aagtgcagtt 10980 ggccataacg gaccagttaa cggtctggtg acccggctgc gagagctcgg tgtacctgag 11040 acgcgagtaa gccctcgagt caaatacgta gtcgttgcaa gtccgcacca ggtactggta 11100 tcccaccaaa aagtgcggcg gcggctggcg gtagaggggc cagcgtaggg tggccggggc 11160 tccgggggcg agatcttcca acataaggcg atgatatccg tagatgtacc tggacatcca 11220 ggtgatgccg gcggcggtgg tggaggcgcg cggaaagtcg cggacgcggt tccagatgtt 11280 gcgcagcggc aaaaagtgct ccatggtcgg gacgctctgg ccggtcaggc gcgcgcaatc 11340 gttgacgctc tagaccgtgc aaaaggagag cctgtaagcg ggcactcttc cgtggtctgg 11400 tggataaatt cgcaagggta tcatggcgga cgaccggggt tcgagccccg tatccggccg 11460 tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc caggtgtgcg acgtcagaca 11520 acgggggagt gctccttttg gcttccttcc aggcgcggcg gctgctgcgc tagctttttt 11580 ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa gcgaaagcat taagtggctc 11640 gctccctgta gccggagggt tattttccaa gggttgagtc gcgggacccc cggttcgagt 11700 ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc ccgtcatgca agaccccgct 11760 tgcaaattcc tccggaaaca gggacgagcc ccttttttgc ttttcccaga tgcatccggt 11820 gctgcggcag atgcgccccc ctcctcagca gcggcaagag caagagcagc ggcagacatg 11880 cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg acatccgcgg ttgacgcggc 11940 agcagatggt gattacgaac ccccgcggcg ccgggcccgg cactacctgg acttggagga 12000 gggcgagggc ctggcgcggc taggagcgcc ctctcctgag cggtacccaa gggtgcagct 12060 gaagcgtgat acgcgtgagg cgtacgtgcc gcggcagaac ctgtttcgcg accgcgaggg 12120 agaggagccc gaggagatgc gggatcgaaa gttccacgca gggcgcgagc tgcggcatgg 12180 cctgaatcgc gagcggttgc tgcgcgagga ggactttgag cccgacgcgc gaaccgggat 12240 tagtcccgcg cgcgcacacg tggcggccgc cgacctggta accgcatacg agcagacggt 12300 gaaccaggag attaactttc aaaaaagctt taacaaccac gtgcgtacgc ttgtggcgcg 12360 cgaggaggtg gctataggac tgatgcatct gtgggacttt gtaagcgcgc tggagcaaaa 12420 cccaaatagc aagccgctca tggcgcagct gttccttata gtgcagcaca gcagggacaa 12480 cgaggcattc agggatgcgc tgctaaacat agtagagccc gagggccgct ggctgctcga 12540 tttgataaac atcctgcaga gcatagtggt gcaggagcgc agcttgagcc tggctgacaa 12600 ggtggccgcc atcaactatt ccatgcttag cctgggcaag ttttacgccc gcaagatata 12660 ccatacccct tacgttccca tagacaagga ggtaaagatc gaggggttct acatgcgcat 12720 ggcgctgaag gtgcttacct tgagcgacga cctgggcgtt tatcgcaacg agcgcatcca 12780 caaggccgtg agcgtgagcc ggcggcgcga gctcagcgac cgcgagctga tgcacagcct 12840 gcaaagggcc ctggctggca cgggcagcgg cgatagagag gccgagtcct actttgacgc 12900 gggcgctgac ctgcgctggg ccccaagccg acgcgccctg gaggcagctg gggccggacc 12960 tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc ggcgtggagg aatatgacga 13020 ggacgatgag tacgagccag aggacggcga gtactaagcg gtgatgtttc tgatcagatg 13080 atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc agagccagcc gtccggcctt 13140 aactccacgg acgactggcg ccaggtcatg gaccgcatca tgtcgctgac tgcgcgcaat 13200 cctgacgcgt tccggcagca gccgcaggcc aaccggctct ccgcaattct ggaagcggtg 13260 gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg cgatcgtaaa cgcgctggcc 13320 gaaaacaggg ccatccggcc cgacgaggcc ggcctggtct acgacgcgct gcttcagcgc 13380 gtggctcgtt acaacagcgg caacgtgcag accaacctgg accggctggt gggggatgtg 13440 cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg gcaacctggg ctccatggtt 13500 gcactaaacg ccttcctgag tacacagccc gccaacgtgc cgcggggaca ggaggactac 13560 accaactttg tgagcgcact gcggctaatg gtgactgaga caccgcaaag tgaggtgtac 13620 cagtctgggc cagactattt tttccagacc agtagacaag gcctgcagac cgtaaacctg 13680 agccaggctt tcaaaaactt gcaggggctg tggggggtgc gggctcccac aggcgaccgc 13740 gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt tgctgctgct aatagcgccc 13800 ttcacggaca gtggcagcgt gtcccgggac acatacctag gtcacttgct gacactgtac 13860 cgcgaggcca taggtcaggc gcatgtggac gagcatactt tccaggagat tacaagtgtc 13920 agccgcgcgc tggggcagga ggacacgggc agcctggagg caaccctaaa ctacctgctg 13980 accaaccggc ggcagaagat cccctcgttg cacagtttaa acagcgagga ggagcgcatt 14040 ttgcgctacg tgcagcagag cgtgagcctt aacctgatgc gcgacggggt aacgcccagc 14100 gtggcgctgg acatgaccgc gcgcaacatg gaaccgggca tgtatgcctc aaaccggccg 14160 tttatcaacc gcctaatgga ctacttgcat cgcgcggccg ccgtgaaccc cgagtatttc 14220 accaatgcca tcttgaaccc gcactggcta ccgccccctg gtttctacac cgggggattc 14280 gaggtgcccg agggtaacga tggattcctc tgggacgaca tagacgacag cgtgttttcc 14340 ccgcaaccgc agaccctgct agagttgcaa cagcgcgagc aggcagaggc ggcgctgcga 14400 aaggaaagct tccgcaggcc aagcagcttg tccgatctag gcgctgcggc cccgcggtca 14460 gatgctagta gcccatttcc aagcttgata gggtctctta ccagcactcg caccacccgc 14520 ccgcgcctgc tgggcgagga ggagtaccta aacaactcgc tgctgcagcc gcagcgcgaa 14580 aaaaacctgc ctccggcatt tcccaacaac gggatagaga gcctagtgga caagatgagt 14640 agatggaaga cgtacgcgca ggagcacagg gacgtgccag gcccgcgccc gcccacccgt 14700 cgtcaaaggc acgaccgtca gcggggtctg gtgtgggagg acgatgactc ggcagacgac 14760 agcagcgtcc tggatttggg agggagtggc aacccgtttg cgcaccttcg ccccaggctg 14820 gggagaatgt tttaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg 14880 gcaccgagcg ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg 14940 aaggtcctcc tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg 15000 gttctccctt cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta 15060 ccggggggag aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg 15120 tgtacctggt ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca 15180 gcaactttct gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac 15240 agaccatcaa tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata 15300 ccaacatgcc aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg 15360 tgtcgcgctt gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca 15420 cgctgcccga gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg 15480 tggagcacta cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa 15540 agtttgacac ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg 15600 gggtatatac aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg 15660 acttcaccca cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg 15720 agggctttag gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg 15780 tggacgccta ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg 15840 gcagcaacag cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc 15900 agccggtgga ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg 15960 aggagaagcg cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg 16020 aggtcgagaa gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac 16080 gcagttacaa cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg 16140 catacaacta cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg 16200 acgtaacctg cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg 16260 tgaccttccg ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc 16320 ccgtgcactc caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt 16380 ttacctctct gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc 16440 cagcccccac catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc 16500 taccgctgcg caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc 16560 gcacctgccc ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc 16620 gcactttttg agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc 16680 tgcgcttccc aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc 16740 gcgtgcgcgg gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca 16800 ccaccgtcga tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc 16860 cgccaccagt gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct 16920 atgctaaaat gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca 16980 ctgccgccca acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg 17040 cggccatgcg ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca 17100 ggcgacgagc ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg 17160 gcaacgtgta ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc 17220 ccccgcgcaa ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag 17280 cggcggcggc gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg 17340 tcatcgcgcc ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa 17400 agctaaagcg ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg 17460 aactgctgca cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac 17520 gtgttttgcg acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct 17580 acaagcgcgt gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc 17640 gcctcgggga gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg 17700 agggcaaccc aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg 17760 caccgtccga agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc 17820 agctgatggt acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac 17880 ctgggctgga gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg 17940 tgcagaccgt ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag 18000 agggcatgga gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg 18060 cggtcgctgc ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc 18120 gcgtttcagc cccccggcgc ccgcgcggtt cgaggaagta cggcgccgcc agcgcgctac 18180 tgcccgaata tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct 18240 accgccccag aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc 18300 gtcgccgtcg ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag 18360 gcaggaccct ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct 18420 ttgtggttct tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc 18480 gaggaagaat gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc 18540 gtgcgcacca ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc 18600 tccttattcc actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct 18660 tgcaggcgca gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt 18720 ctggactctc acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt 18780 gcgtctctgg ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc 18840 accagcaata tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat 18900 ttcggttcca ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg 18960 ctgagggata agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct 19020 ggcattagcg gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag 19080 cttgatcccc gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag 19140 gggcgtggcg aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac 19200 gagcctccct cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg 19260 cccatggcta ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc 19320 gccgacaccc agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct 19380 agccgcgcgt ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt 19440 ggcaactggc aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc 19500 cgacgatgct tctgaatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc 19560 gccagaggag ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga 19620 tgccgcagtg gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg 19680 ggctggtgca gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa 19740 accccacggt ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc 19800 ggttcatccc tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag 19860 ctgtgggtga taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc 19920 tggacagggg ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca 19980 agggtgcccc aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag 20040 aagaagagga cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc 20100 acgtatttgg gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag 20160 gtgtcgaagg tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag 20220 gagaatctca gtggtacgaa actgaaatta atcatgcagc tgggagagtc cttaaaaaga 20280 ctaccccaat gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc 20340 aaggcattct tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt 20400 tctcaactac tgaggcgacc gcaggcaatg gtgataactt gactcctaaa gtggtattgt 20460 acagtgaaga tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta 20520 aggaaggtaa ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca 20580 ttgcttttag ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg 20640 ttctggcggg ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag 20700 agctttcata ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt 20760 ggaatcaggc tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg 20820 aagatgaact tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta 20880 ccaaggtaaa acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt 20940 cagataaaaa tgaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca 21000 acctgtggag aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt 21060 acagtccttc caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc 21120 gagtggtggc tcccgggtta gtggactgct acattaacct tggagcacgc tggtcccttg 21180 actatatgga caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct 21240 caatgttgct gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct 21300 ttgccattaa aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga 21360 aggatgttaa catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca 21420 gcattaagtt tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg 21480 cctccacgct tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc 21540 tctccgccgc caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca 21600 tcccctcccg caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg 21660 aaaccccatc actgggctcg ggctacgacc cttattacac ctactctggc tctataccct 21720 acctagatgg aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact 21780 cttctgtcag ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc 21840 gctcagttga cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc 21900 tggtacaaat gctagctaac tacaacattg gctaccaggg cttctatatc ccagagagct 21960 acaaggaccg catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg 22020 atgatactaa atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg 22080 gatttgttgg ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc 22140 cctatccgct tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg 22200 atcgcaccct ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag 22260 acctgggcca aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg 22320 tggatcccat ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc 22380 gtgtgcaccg gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg 22440 ccggcaacgc cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc 22500 cagtgagcag gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg 22560 cacctatgac aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt 22620 caatacggcc ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca 22680 ctcaaaaaca tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt 22740 ttaccagttt gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg 22800 ctgtataacg ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg 22860 actattctgc tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca 22920 caaccccacc atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt 22980 acagcccacc ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc 23040 ctacttccgc agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa 23100 catgtaaaaa taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac 23160 tctcgggtga ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt 23220 ctgccgcgca tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct 23280 ccacttaaac tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct 23340 gcgcaccatc accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg 23400 gcctccgccc tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag 23460 cgccgggtgg tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc 23520 ctccgcgttg ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc 23580 gtgcccaggc tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt 23640 ctgggcgtta ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc 23700 ctttgcgcct tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca 23760 ggccgcgtcg tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc 23820 ccaccggttc ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt 23880 ttcgctcgtc acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag 23940 acacttaagc tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg 24000 ctcgtgatgc ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc 24060 catcatcgtc acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc 24120 gttcagccag gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa 24180 gttcgccttt agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat 24240 gcccttctcc cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact 24300 ttccgcttcg ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc 24360 gtcttcattc agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg 24420 tgggttgctg aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac 24480 gattacctct ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt 24540 gggcgcaatg gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac 24600 cagcgcgtct tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt 24660 ttttgggggc gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt 24720 tgggggacgt cgcgccgcac cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc 24780 ccgactggcc atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa 24840 ggacagccta accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc 24900 gcctaccacc ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca 24960 ggacccaggt tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa 25020 gcaagaccag gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca 25080 tggcgactac ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc 25140 cattatctgc gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag 25200 ccttgcctac gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg 25260 cacatgcgag cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct 25320 tgccacctat cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg 25380 cagccgagcg gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc 25440 gctcaacgaa gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa 25500 cgctctgcaa caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga 25560 gggtgacaac gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta 25620 cccggcactt aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg 25680 ccgtgcgcag cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc 25740 cgcagttggc gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga 25800 ggagcgacgc aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca 25860 gcggttcttt gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt 25920 tcgacagggc tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt 25980 ctcctacctt ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct 26040 caagggcgag gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac 26100 ctggcagacg gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct 26160 gcagaaactg ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt 26220 ggccgcgcac ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg 26280 tctgccagac ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg 26340 ctcaggaatc ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta 26400 ccgcgaatgc cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct 26460 tgcctaccac tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg 26520 tcgctgcaac ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga 26580 aagtcaaatt atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc 26640 tccggggttg aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc 26700 tgaggactac cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccaaatgc 26760 ggagcttacc gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa 26820 caaagcccgc caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc 26880 cggcgaggag ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc 26940 ccttgcttcc caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg 27000 aggaggaata ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga 27060 tggaagactg ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa 27120 caccgtcacc ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca 27180 gcatggctac aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc 27240 gtagatggga caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc 27300 aagagcaaca acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg 27360 cttgcttgca agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc 27420 acggcgtggc cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact 27480 gcaccggcgg cagcggcagc ggcagcaaca gcagcggcca cacagaagca aaggcgaccg 27540 gatagcaaga ctctgacaaa gcccaagaaa tccacagcgg cggcagcagc aggaggagga 27600 gcgctgcgtc tggcgcccaa cgaacccgta tcgacccgcg agcttagaaa caggattttt 27660 cccactctgt atgctatatt tcaacagagc aggggccaag aacaagagct gaaaataaaa 27720 aacaggtctc tgcgatccct cacccgcagc tgcctgtatc acaaaagcga agatcagctt 27780 cggcgcacgc tggaagacgc ggaggctctc ttcagtaaat actgcgcgct gactcttaag 27840 gactagtttc gcgccctttc tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca 27900 cacccggcgc cagcacctgt cgtcagcgcc atttcaactt tgtatacaaa agttgtgatg 27960 agcaaggaaa ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct 28020 ggagctgccc aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata 28080 tcccgggtca acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt 28140 accaccacac ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag 28200 gaaagtcccg ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg 28260 actaactcag gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag 28320 ggtataactc acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc 28380 tcctcgcttg gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca 28440 ttcacgcctc gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga 28500 ggcattggaa ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc 28560 tcgggacctc ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac 28620 tcggcggacg gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac 28680 ctggtccact gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt 28740 gaattgcccg aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga 28800 gagcttgccc gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac 28860 aggggaccct gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat 28920 ctttgttgcc atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc 28980 ctatcgccat cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt 29040 acctggtact tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt 29100 gagtctacga gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct 29160 tacctgccgg gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg 29220 taaaccagac tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc 29280 ttagaaaacc cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt 29340 caagcaactc tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc 29400 tctgtcttgt gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct 29460 gctgtgtgca catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat 29520 gattaggtac ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa 29580 ggtggatttt aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac 29640 cactcttata aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat 29700 tggcaagtat gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac 29760 agttttccag ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg 29820 cgacattacc atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga 29880 aaacactggc actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac 29940 cctactctat attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta 30000 atttactaag ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca 30060 aattcaaaaa gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct 30120 caataccatt cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg 30180 aagtcaggct tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt 30240 tccagtccaa ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc 30300 cgctaccgga cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg 30360 ggataacttg ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat 30420 gtggctcatc tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat 30480 tgtgctacac ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt 30540 ttctcttaca gtatgattaa atgagacatg attcctcgag tttttatatt actgaccctt 30600 gttgcgcttt tttgtgcgtg ctccacattg gctgcggttt ctcacatcga agtagactgc 30660 attccagcct tcacagtcta tttgctttac ggatttgtca ccctcacgct catctgcagc 30720 ctcatcactg tggtcatcgc ctttatccag tgcattgact gggtctgtgt gcgctttgca 30780 tatctcagac accatcccca gtacagggac aggactatag ctgagcttct tagaattctt 30840 taattatgaa atttactgtg acttttctgc tgattatttg caccctatct gcgttttgtt 30900 ccccgacctc caagcctcaa agacatatat catgcagatt cactcgtata tggaatattc 30960 caagttgcta caatgaaaaa agcgatcttt ccgaagcctg gttatatgca atcatctctg 31020 ttatggtgtt ctgcagtacc atcttagccc tagctatata tccctacctt gacattggct 31080 ggaacgcaat agatgccatg aaccacccaa ctttccccgc gcccgctatg cttccactgc 31140 aacaagttgt tgccggcggc tttgtcccag ccaatcagcc tcgcccacct tctcccaccc 31200 ccactgaaat cagctacttt aatctaacag gaggagatga ctgacaccct agatctagaa 31260 atggacggaa ttattacaga gcagcgcctg ctagaaagac gcagggcagc ggccgagcaa 31320 cagcgcatga atcaagagct ccaagacatg gttaacttgc accagtgcaa aaggggtatc 31380 ttttgtctgg taaagcaggc caaagtcacc tacgacagta ataccaccgg acaccgcctt 31440 agctacaagt tgccaaccaa gcgtcagaaa ttggtggtca tggtgggaga aaagcccatt 31500 accataactc agcactcggt agaaaccgaa ggctgcattc actcaccttg tcaaggacct 31560 gaggatctct gcacccttat taagaccctg tgcggtctca aagatcttat tccctttaac 31620 taataaaaaa aaataataaa gcatcactta cttaaaatca gttagcaaat ttctgtccag 31680 tttattcagc agcacctcct tgccctcctc ccagctctgg tattgcagct tcctcctggc 31740 tgcaaacttt ctccacaatc taaatggaat gtcagtttcc tcctgttcct gtccatccgc 31800 acccactatc ttcatgttgt tgcagatgaa gcgcgcaaga ccgtctgaag ataccttcaa 31860 ccccgtgtat ccatatgaca cggaaaccgg tcctccaact gtgccttttc ttactcctcc 31920 ctttgtatcc cccaatgggt ttcaagagag tccccctggg gtactctctt tgcgcctatc 31980 cgaacctcta gttacctcca atggcatgct tgcgctcaaa atgggcaacg gcctctctct 32040 ggacgaggcc ggcaacctta cctcccaaaa tgtaaccact gtgagcccac ctctcaaaaa 32100 aaccaagtca aacataaacc tggaaatatc tgcacccctc acagttacct cagaagccct 32160 aactgtggct gccgccgcac ctctaatggt cgcgggcaac acactcacca tgcaatcaca 32220 ggccccgcta accgtgcacg actccaaact tagcattgcc acccaaggac ccctcacagt 32280 gtcagaagga aagctagccc tgcaaacatc aggccccctc accaccaccg atagcagtac 32340 ccttactatc actgcctcac cccctctaac tactgccact ggtagcttgg gcattgactt 32400 gaaagagccc atttatacac aaaatggaaa actaggacta aagtacgggg ctcctttgca 32460 tgtaacagac gacctaaaca ctttgaccgt agcaactggt ccaggtgtga ctattaataa 32520 tacttccttg caaactaaag ttactggagc cttgggtttt gattcacaag gcaatatgca 32580 acttaatgta gcaggaggac taaggattga ttctcaaaac agacgcctta tacttgatgt 32640 tagttatccg tttgatgctc aaaaccaact aaatctaaga ctaggacagg gccctctttt 32700 tataaactca gcccacaact tggatattaa ctacaacaaa ggcctttact tgtttacagc 32760 ttcaaacaat tccaaaaagc ttgaggttaa cctaagcact gccaaggggt tgatgtttga 32820 cgctacagcc atagccatta atgcaggaga tgggcttgaa tttggttcac ctaatgcacc 32880 aaacacaaat cccctcaaaa caaaaattgg ccatggccta gaatttgatt caaacaaggc 32940 tatggttcct aaactaggaa ctggccttag ttttgacagc acaggtgcca ttacagtagg 33000 aaacaaaaat aatgataagc taactttgtg gaccacacca gctccatctc ctaactgtag 33060 actaaatgca gagaaagatg ctaaactcac tttggtctta acaaaatgtg gcagtcaaat 33120 acttgctaca gtttcagttt tggctgttaa aggcagtttg gctccaatat ctggaacagt 33180 tcaaagtgct catcttatta taagatttga cgaaaatgga gtgctactaa acaattcctt 33240 cctggaccca gaatattgga actttagaaa tggagatctt actgaaggca cagcctatac 33300 aaacgctgtt ggatttatgc ctaacctatc agcttatcca aaatctcacg gtaaaactgc 33360 caaaagtaac attgtcagtc aagtttactt aaacggagac aaaactaaac ctgtaacact 33420 aaccattaca ctaaacggta cacaggaaac aggagacaca actgagatgt ggcatgaagg 33480 cctagaagag gcctctcgct tgtactttgg ggagaggaac gtcaaaggca tgtttgaggt 33540 gctggagccc ctgcatgcta tgatggaacg cggtccccag accctgaagg aaacgtcctt 33600 taatcaggca tatggtcgag atttaatgga ggcacaagaa tggtgccgaa agtacatgaa 33660 atcagggaac gtcaaggacc tcacccaagc ctgggacctc tactatcacg tgttcagacg 33720 aatctcaaag cagccaagtg catactctat gtcattttca tgggactggt ctggccacaa 33780 ctacattaat gaaatatttg ccacatcctc ttacactttt tcatacattg cccaagaata 33840 aagaatcgtt tgtgttatgt ttcaacgtgt ttatttttca attgcagaaa atttcgaatc 33900 atttttcatt cagtagtata gccccaccac cacatagctt atacagatca ccgtacctca 33960 actttgtata ataaagttgt aatcaaactc acagaaccct agtattcaac ctgccacctc 34020 cctcccaaca cacagagtac acagtccttt ctccccggct ggccttaaaa agcatcatat 34080 catgggtaac agacatattc ttaggtgtta tattccacac ggtttcctgt cgagccaaac 34140 gctcatcagt gatattaata aactccccgg gcagctcact taagttcatg tcgctgtcca 34200 gctgctgagc cacaggctgc tgtccaactt gcggttgctt aacgggcggc gaaggagaag 34260 tccacgccta catgggggta gagtcataat cgtgcatcag gatagggcgg tggtgctgca 34320 gcagcgcgcg aataaactgc tgccgccgcc gctccgtcct gcaggaatac aacatggcag 34380 tggtctcctc agcgatgatt cgcaccgccc gcagcataag gcgccttgtc ctccgggcac 34440 agcagcgcac cctgatctca cttaaatcag cacagtaact gcagcacagc accacaatat 34500 tgttcaaaat cccacagtgc aaggcgctgt atccaaagct catggcgggg accacagaac 34560 ccacgtggcc atcataccac aagcgcaggt agattaagtg gcgacccctc ataaacacgc 34620 tggacataaa cattacctct tttggcatgt tgtaattcac cacctcccgg taccatataa 34680 acctctgatt aaacatggcg ccatccacca ccatcctaaa ccagctggcc aaaacctgcc 34740 cgccggctat acactgcagg gaaccgggac tggaacaatg acagtggaga gcccaggact 34800 cgtaaccatg gatcatcatg ctcgtcatga tatcaatgtt ggcacaacac aggcacacgt 34860 gcatacactt cctcaggatt acaagctcct cccgcgttag aaccatatcc cagggaacaa 34920 cccattcctg aatcagcgta aatcccacac tgcagggaag acctcgcacg taactcacgt 34980 tgtgcattgt caaagtgtta cattcgggca gcagcggatg atcctccagt atggtagcgc 35040 gggtttctgt ctcaaaagga ggtagacgat ccctactgta cggagtgcgc cgagacaacc 35100 gagatcgtgt tggtcgtagt gtcatgccaa atggaacgcc ggacgtagtc atatttcctg 35160 aagcaaaacc aggtgcgggc gtgacaaaca gatctgcgtc tccggtctcg ccgcttagat 35220 cgctctgtgt agtagttgta gtatatccac tctctcaaag catccaggcg ccccctggct 35280 tcgggttcta tgtaaactcc ttcatgcgcc gctgccctga taacatccac caccgcagaa 35340 taagccacac ccagccaacc tacacattcg ttctgcgagt cacacacggg aggagcggga 35400 agagctggaa gaaccatgtt ttttttttta ttccaaaaga ttatccaaaa cctcaaaatg 35460 aagatctatt aagtgaacgc gctcccctcc ggtggcgtgg tcaaactcta cagccaaaga 35520 acagataatg gcatttgtaa gatgttgcac aatggcttcc aaaaggcaaa cggccctcac 35580 gtccaagtgg acgtaaaggc taaacccttc agggtgaatc tcctctataa acattccagc 35640 accttcaacc atgcccaaat aattctcatc tcgccacctt ctcaatatat ctctaagcaa 35700 atcccgaata ttaagtccgg ccattgtaaa aatctgctcc agagcgccct ccaccttcag 35760 cctcaagcag cgaatcatga ttgcaaaaat tcaggttcct cacagacctg tataagattc 35820 aaaagcggaa cattaacaaa aataccgcga tcccgtaggt cccttcgcag ggccagctga 35880 acataatcgt gcaggtctgc acggaccagc gcggccactt ccccgccagg aaccatgaca 35940 aaagaaccca cactgattat gacacgcata ctcggagcta tgctaaccag cgtagccccg 36000 atgtaagctt gttgcatggg cggcgatata aaatgcaagg tgctgctcaa aaaatcaggc 36060 aaagcctcgc gcaaaaaaga aagcacatcg tagtcatgct catgcagata aaggcaggta 36120 agctccggaa ccaccacaga aaaagacacc atttttctct caaacatgtc tgcgggtttc 36180 tgcataaaca caaaataaaa taacaaaaaa acatttaaac attagaagcc tgtcttacaa 36240 caggaaaaac aacccttata agcataagac ggactacggc catgccggcg tgaccgtaaa 36300 aaaactggtc accgtgatta aaaagcacca ccgacagctc ctcggtcatg tccggagtca 36360 taatgtaaga ctcggtaaac acatcaggtt gattcacatc ggtcagtgct aaaaagcgac 36420 cgaaatagcc cgggggaata catacccgca ggcgtagaga caacattaca gcccccatag 36480 gaggtataac aaaattaata ggagagaaaa acacataaac acctgaaaaa ccctcctgcc 36540 taggcaaaat agcaccctcc cgctccagaa caacatacag cgcttccaca gcggcagcca 36600 taacagtcag ccttaccagt aaaaaagaaa acctattaaa aaaacaccac tcgacacggc 36660 accagctcaa tcagtcacag tgtaaaaaag ggccaagtgc agagcgagta tatataggac 36720 taaaaaatga cgtaacggtt aaagtccaca aaaaacaccc agaaaaccgc acgcgaacct 36780 acgcccagaa acgaaagcca aaaaacccac aacttcctca aatcgtcact tccgttttcc 36840 cacgttacgt cacttcccat tttaagaaaa ctacaattcc caacacatac aagttactcc 36900 gccctaaaac ctacgtcacc cgccccgttc ccacgccccg cgccacgtca caaactccac 36960 cccctcatta tcatattggc ttcaatccaa aataaggtat attattgatg atg 37013 <210> 91 <211> 36011 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO170) <400> 91 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccca acttttctat acaaagttgt aatgagcacc aactcgtttg atggaagcat 3660 tgtgagctca tatttgacaa cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat 3720 gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct tgacctacga 3780 gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag ccgctgcagc 3840 caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc 3900 ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat tggattcttt 3960 gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc aggtttctgc 4020 cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac cagactctgt 4080 ttggatttgg atcaagcata agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg 4140 taggcccggg accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg 4200 taaaggtgac tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag 4260 caccactgca gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag 4320 cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc 4380 ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga 4440 tgcatcttgg actgtatttt taggttggct atgttcccag ccatatccct ccggggattc 4500 atgttgtgca gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc 4560 ttagaaggaa atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg 4620 cattcgtcca taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg 4680 ggatcactaa cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag 4740 cgcgggcgga gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta 4800 ccctcacaga tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc 4860 ggggcgatga agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc 4920 ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccggctgc 4980 aactggtagt taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta 5040 agcatgtccc tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc 5100 agcgatagca gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta 5160 ggcatgcttt tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc 5220 tctacggcat ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt 5280 acggcagtag tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg 5340 tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca 5400 gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt 5460 cggccaggta gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg 5520 cgcgcagctt gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt 5580 agagcttggg cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc 5640 agacggtctc gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt 5700 ttcccccatg ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct 5760 cggtgacgaa aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg 5820 gtgttccgcg gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc 5880 aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca 5940 ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt 6000 tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg 6060 cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt 6120 actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg 6180 aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt 6240 cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg 6300 acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg 6360 ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg 6420 tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa 6480 cgctggtggc tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc 6540 gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg 6600 taaagacccc gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta 6660 gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc 6720 atggcatggg gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg 6780 gctctctgag tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca 6840 cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg 6900 gctgctctgc tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg 6960 gacgctggaa gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg 7020 cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt 7080 agtccagggt ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc 7140 ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct 7200 ccgaacggta agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct 7260 tttctacggg tagcgcgtat gcctgcgcgg ccttccggag cgaggtgtgg gtgagcgcaa 7320 aggtgtccct gaccatgact ttgaggtact ggtatttgaa gtcagtgtcg tcgcatccgc 7380 cctgctccca gagcaaaaag tccgtgcgct ttttggaacg cggatttggc agggcgaagg 7440 tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa gttgcgtgtg atgcggaagg 7500 gtcccggcac ctcggaacgg ttgttaatta cctgggcggc gagcacgatc tcgtcaaagc 7560 cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg cgggatgccc ttgatggaag 7620 gcaatttttt aagttcctcg taggtgagct cttcagggga gctgagcccg tgctctgaaa 7680 gggcccagtc tgcaagatga gggttggaag cgacgaatga gctccacagg tcacgggcca 7740 ttagcatttg caggtggtcg cgaaaggtcc taaactggcg acctatggcc attttttctg 7800 gggtgatgca gtagaaggta agcgggtctt gttcccagcg gtcccatcca aggttcgcgg 7860 ctaggtctcg cgcggcagtc actagaggct catctccgcc gaacttcatg accagcatga 7920 agggcacgag ctgcttccca aaggccccca tccaagtata ggtctctaca tcgtaggtga 7980 caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa gaactggatc tcccgccacc 8040 aattggagga gtggctattg atgtggtgaa agtagaagtc cctgcgacgg gccgaacact 8100 cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg gtgcacgggc tgtacatcct 8160 gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag tgggaatttg agcccctcgc 8220 ctggcgggtt tggctggtgg tcttctactt cggctgcttg tccttgaccg tctggctgct 8280 cgaggggagt tacggtggat cggaccacca cgccgcgcga gcccaaagtc cagatgtccg 8340 cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg ggagctgtcc atggtctgga 8400 gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt tacctcgcat agacgggtca 8460 gggcgcgggc tagatccagg tgatacctaa tttccagggg ctggttggtg gcggcgtcga 8520 tggcttgcaa gaggccgcat ccccgcggcg cgactacggt accgcgcggc gggcggtggg 8580 ccgcgggggt gtccttggat gatgcatcta aaagcggtga cgcgggcgag cccccggagg 8640 tagggggggc tccggacccg ccgggagagg gggcaggggc acgtcggcgc cgcgcgcggg 8700 caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg acgacgcggc ggttgatctc 8760 ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg agcttgaacc tgaaagagag 8820 ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg cgcaaaatct cctgcacgtc 8880 tcctgagttg tcttgatagg cgatctcggc catgaactgc tcgatctctt cctcctggag 8940 atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg ttggaaatgc gggccatgag 9000 ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg ctgtagacca cgcccccttc 9060 ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc tccacgtgcc gggcgaagac 9120 ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg gtggcggtgt gttctgccac 9180 gaagaagtac ataacccagc gtcgcaacgt ggattcgttg atatccccca aggcctcaag 9240 gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga 9300 cacggttaac tcctcctcca gaagacggat gagctcggcg acagtgtcgc gcacctcgcg 9360 ctcaaaggct acaggggcct cttcttcttc ttcaatctcc tcttccataa gggcctcccc 9420 ttcttcttct tctggcggcg gtgggggagg ggggacacgg cggcgacgac ggcgcaccgg 9480 gaggcggtcg acaaagcgct cgatcatctc cccgcggcga cggcgcatgg tctcggtgac 9540 ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg cccgtcatgt cccggttatg 9600 ggttggcggg gggctgccat gcggcaggga tacggcgcta acgatgcatc tcaacaattg 9660 ttgtgtaggt actccgccgc cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa 9720 cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca ccgtggcggg 9780 cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa 9840 gtaggcggtc ttgagacggc ggatggtcga cagaagcacc atgtccttgg gtccggcctg 9900 ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt tgacatcggc gcaggtcttt 9960 gtagtagtct tgcatgagcc tttctaccgg cacttcttct tctccttcct cttgtcctgc 10020 atctcttgca tctatcgctg cggcggcggc ggagtttggc cgtaggtggc gccctcttcc 10080 tcccatgcgt gtgaccccga agcccctcat cggctgaagc agggctaggt cggcgacaac 10140 gcgctcggct aatatggcct gctgcacctg cgtgagggta gactggaagt catccatgtc 10200 cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg cagttggcca taacggacca 10260 gttaacggtc tggtgacccg gctgcgagag ctcggtgtac ctgagacgcg agtaagccct 10320 cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac tggtatccca ccaaaaagtg 10380 cggcggcggc tggcggtaga ggggccagcg tagggtggcc ggggctccgg gggcgagatc 10440 ttccaacata aggcgatgat atccgtagat gtacctggac atccaggtga tgccggcggc 10500 ggtggtggag gcgcgcggaa agtcgcggac gcggttccag atgttgcgca gcggcaaaaa 10560 gtgctccatg gtcgggacgc tctggccggt caggcgcgcg caatcgttga cgctctagac 10620 cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg tctggtggat aaattcgcaa 10680 gggtatcatg gcggacgacc ggggttcgag ccccgtatcc ggccgtccgc cgtgatccat 10740 gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc agacaacggg ggagtgctcc 10800 ttttggcttc cttccaggcg cggcggctgc tgcgctagct tttttggcca ctggccgcgc 10860 gcagcgtaag cggttaggct ggaaagcgaa agcattaagt ggctcgctcc ctgtagccgg 10920 agggttattt tccaagggtt gagtcgcggg acccccggtt cgagtctcgg accggccgga 10980 ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc ccgcttgcaa attcctccgg 11040 aaacagggac gagccccttt tttgcttttc ccagatgcat ccggtgctgc ggcagatgcg 11100 cccccctcct cagcagcggc aagagcaaga gcagcggcag acatgcaggg caccctcccc 11160 tcctcctacc gcgtcaggag gggcgacatc cgcggttgac gcggcagcag atggtgatta 11220 cgaacccccg cggcgccggg cccggcacta cctggacttg gaggagggcg agggcctggc 11280 gcggctagga gcgccctctc ctgagcggca cccaagggtg cagctgaagc gtgatacgcg 11340 tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc gagggagagg agcccgagga 11400 gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg catggcctga atcgcgagcg 11460 gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc gggattagtc ccgcgcgcgc 11520 acacgtggcg gccgccgacc tggtaaccgc atacgagcag acggtgaacc aggagattaa 11580 ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg gcgcgcgagg aggtggctat 11640 aggactgatg catctgtggg actttgtaag cgcgctggag caaaacccaa atagcaagcc 11700 gctcatggcg cagctgttcc ttatagtgca gcacagcagg gacaacgagg cattcaggga 11760 tgcgctgcta aacatagtag agcccgaggg ccgctggctg ctcgatttga taaacatcct 11820 gcagagcata gtggtgcagg agcgcagctt gagcctggct gacaaggtgg ccgccatcaa 11880 ctattccatg cttagcctgg gcaagtttta cgcccgcaag atataccata ccccttacgt 11940 tcccatagac aaggaggtaa agatcgaggg gttctacatg cgcatggcgc tgaaggtgct 12000 taccttgagc gacgacctgg gcgtttatcg caacgagcgc atccacaagg ccgtgagcgt 12060 gagccggcgg cgcgagctca gcgaccgcga gctgatgcac agcctgcaaa gggccctggc 12120 tggcacgggc agcggcgata gagaggccga gtcctacttt gacgcgggcg ctgacctgcg 12180 ctgggcccca agccgacgcg ccctggaggc agctggggcc ggacctgggc tggcggtggc 12240 acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat gacgaggacg atgagtacga 12300 gccagaggac ggcgagtact aagcggtgat gtttctgatc agatgatgca agacgcaacg 12360 gacccggcgg tgcgggcggc gctgcagagc cagccgtccg gccttaactc cacggacgac 12420 tggcgccagg tcatggaccg catcatgtcg ctgactgcgc gcaatcctga cgcgttccgg 12480 cagcagccgc aggccaaccg gctctccgca attctggaag cggtggtccc ggcgcgcgca 12540 aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc tggccgaaaa cagggccatc 12600 cggcccgacg aggccggcct ggtctacgac gcgctgcttc agcgcgtggc tcgttacaac 12660 agcggcaacg tgcagaccaa cctggaccgg ctggtggggg atgtgcgcga ggccgtggcg 12720 cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca tggttgcact aaacgccttc 12780 ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg actacaccaa ctttgtgagc 12840 gcactgcggc taatggtgac tgagacaccg caaagtgagg tgtaccagtc tgggccagac 12900 tattttttcc agaccagtag acaaggcctg cagaccgtaa acctgagcca ggctttcaaa 12960 aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg accgcgcgac cgtgtctagc 13020 ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag cgcccttcac ggacagtggc 13080 agcgtgtccc gggacacata cctaggtcac ttgctgacac tgtaccgcga ggccataggt 13140 caggcgcatg tggacgagca tactttccag gagattacaa gtgtcagccg cgcgctgggg 13200 caggaggaca cgggcagcct ggaggcaacc ctaaactacc tgctgaccaa ccggcggcag 13260 aagatcccct cgttgcacag tttaaacagc gaggaggagc gcattttgcg ctacgtgcag 13320 cagagcgtga gccttaacct gatgcgcgac ggggtaacgc ccagcgtggc gctggacatg 13380 accgcgcgca acatggaacc gggcatgtat gcctcaaacc ggccgtttat caaccgccta 13440 atggactact tgcatcgcgc ggccgccgtg aaccccgagt atttcaccaa tgccatcttg 13500 aacccgcact ggctaccgcc ccctggtttc tacaccgggg gattcgaggt gcccgagggt 13560 aacgatggat tcctctggga cgacatagac gacagcgtgt tttccccgca accgcagacc 13620 ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc tgcgaaagga aagcttccgc 13680 aggccaagca gcttgtccga tctaggcgct gcggccccgc ggtcagatgc tagtagccca 13740 tttccaagct tgatagggtc tcttaccagc actcgcacca cccgcccgcg cctgctgggc 13800 gaggaggagt acctaaacaa ctcgctgctg cagccgcagc gcgaaaaaaa cctgcctccg 13860 gcatttccca acaacgggat agagagccta gtggacaaga tgagtagatg gaagacgtac 13920 gcgcaggagc acagggacgt gccaggcccg cgcccgccca cccgtcgtca aaggcacgac 13980 cgtcagcggg gtctggtgtg ggaggacgat gactcggcag acgacagcag cgtcctggat 14040 ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca ggctggggag aatgttttaa 14100 aaaaaaaaaa aaagcatgat gcaaaataaa aaactcacca aggccatggc accgagcgtt 14160 ggttttcttg tattcccctt agtatgcggc gcgcggcgat gtatgaggaa ggtcctcctc 14220 cctcctacga gagtgtggtg agcgcggcgc cagtggcggc ggcgctgggt tctcccttcg 14280 atgctcccct ggacccgccg tttgtgcctc cgcggtacct gcggcctacc ggggggagaa 14340 acagcatccg ttactctgag ttggcacccc tattcgacac cacccgtgtg tacctggtgg 14400 acaacaagtc aacggatgtg gcatccctga actaccagaa cgaccacagc aactttctga 14460 ccacggtcat tcaaaacaat gactacagcc cgggggaggc aagcacacag accatcaatc 14520 ttgacgaccg gtcgcactgg ggcggcgacc tgaaaaccat cctgcatacc aacatgccaa 14580 atgtgaacga gttcatgttt accaataagt ttaaggcgcg ggtgatggtg tcgcgcttgc 14640 ctactaagga caatcaggtg gagctgaaat acgagtgggt ggagttcacg ctgcccgagg 14700 gcaactactc cgagaccatg accatagacc ttatgaacaa cgcgatcgtg gagcactact 14760 tgaaagtggg cagacagaac ggggttctgg aaagcgacat cggggtaaag tttgacaccc 14820 gcaacttcag actggggttt gaccccgtca ctggtcttgt catgcctggg gtatatacaa 14880 acgaagcctt ccatccagac atcattttgc tgccaggatg cggggtggac ttcacccaca 14940 gccgcctgag caacttgttg ggcatccgca agcggcaacc cttccaggag ggctttagga 15000 tcacctacga tgatctggag ggtggtaaca ttcccgcact gttggatgtg gacgcctacc 15060 aggcgagctt gaaagatgac accgaacagg gcgggggtgg cgcaggcggc agcaacagca 15120 gtggcagcgg cgcggaagag aactccaacg cggcagccgc ggcaatgcag ccggtggagg 15180 acatgaacga tcatgccatt cgcggcgaca cctttgccac acgggctgag gagaagcgcg 15240 ctgaggccga agcagcggcc gaagctgccg cccccgctgc gcaacccgag gtcgagaagc 15300 ctcagaagaa accggtgatc aaacccctga cagaggacag caagaaacgc agttacaacc 15360 taataagcaa tgacagcacc ttcacccagt accgcagctg gtaccttgca tacaactacg 15420 gcgaccctca gaccggaatc cgctcatgga ccctgctttg cactcctgac gtaacctgcg 15480 gctcggagca ggtctactgg tcgttgccag acatgatgca agaccccgtg accttccgct 15540 ccacgcgcca gatcagcaac tttccggtgg tgggcgccga gctgttgccc gtgcactcca 15600 agagcttcta caacgaccag gccgtctact cccaactcat ccgccagttt acctctctga 15660 cccacgtgtt caatcgcttt cccgagaacc agattttggc gcgcccgcca gcccccacca 15720 tcaccaccgt cagtgaaaac gttcctgctc tcacagatca cgggacgcta ccgctgcgca 15780 acagcatcgg aggagtccag cgagtgacca ttactgacgc cagacgccgc acctgcccct 15840 acgtttacaa ggccctgggc atagtctcgc cgcgcgtcct atcgagccgc actttttgag 15900 caagcatgtc catccttata tcgcccagca ataacacagg ctggggcctg cgcttcccaa 15960 gcaagatgtt tggcggggcc aagaagcgct ccgaccaaca cccagtgcgc gtgcgcgggc 16020 actaccgcgc gccctggggc gcgcacaaac gcggccgcac tgggcgcacc accgtcgatg 16080 acgccatcga cgcggtggtg gaggaggcgc gcaactacac gcccacgccg ccaccagtgt 16140 ccacagtgga cgcggccatt cagaccgtgg tgcgcggagc ccggcgctat gctaaaatga 16200 agagacggcg gaggcgcgta gcacgtcgcc accgccgccg acccggcact gccgcccaac 16260 gcgcggcggc ggccctgctt aaccgcgcac gtcgcaccgg ccgacgggcg gccatgcggg 16320 ccgctcgaag gctggccgcg ggtattgtca ctgtgccccc caggtccagg cgacgagcgg 16380 ccgccgcagc agccgcggcc attagtgcta tgactcaggg tcgcaggggc aacgtgtatt 16440 gggtgcgcga ctcggttagc ggcctgcgcg tgcccgtgcg cacccgcccc ccgcgcaact 16500 agattgcaag aaaaaactac ttagactcgt actgttgtat gtatccagcg gcggcggcgc 16560 gcaacgaagc tatgtccaag cgcaaaatca aagaagagat gctccaggtc atcgcgccgg 16620 agatctatgg ccccccgaag aaggaagagc aggattacaa gccccgaaag ctaaagcggg 16680 tcaaaaagaa aaagaaagat gatgatgatg aacttgacga cgaggtggaa ctgctgcacg 16740 ctaccgcgcc caggcgacgg gtacagtgga aaggtcgacg cgtaaaacgt gttttgcgac 16800 ccggcaccac cgtagtcttt acgcccggtg agcgctccac ccgcacctac aagcgcgtgt 16860 atgatgaggt gtacggcgac gaggacctgc ttgagcaggc caacgagcgc ctcggggagt 16920 ttgcctacgg aaagcggcat aaggacatgc tggcgttgcc gctggacgag ggcaacccaa 16980 cacctagcct aaagcccgta acactgcagc aggtgctgcc cgcgcttgca ccgtccgaag 17040 aaaagcgcgg cctaaagcgc gagtctggtg acttggcacc caccgtgcag ctgatggtac 17100 ccaagcgcca gcgactggaa gatgtcttgg aaaaaatgac cgtggaacct gggctggagc 17160 ccgaggtccg cgtgcggcca atcaagcagg tggcgccggg actgggcgtg cagaccgtgg 17220 acgttcagat acccactacc agtagcacca gtattgccac cgccacagag ggcatggaga 17280 cacaaacgtc cccggttgcc tcagcggtgg cggatgccgc ggtgcaggcg gtcgctgcgg 17340 ccgcgtccaa gacctctacg gaggtgcaaa cggacccgtg gatgtttcgc gtttcagccc 17400 cccggcgccc gcgccgttcg aggaagtacg gcgccgccag cgcgctactg cccgaatatg 17460 ccctacatcc ttccattgcg cctacccccg gctatcgtgg ctacacctac cgccccagaa 17520 gacgagcaac tacccgacgc cgaaccacca ctggaacccg ccgccgccgt cgccgtcgcc 17580 agcccgtgct ggccccgatt tccgtgcgca gggtggctcg cgaaggaggc aggaccctgg 17640 tgctgccaac agcgcgctac caccccagca tcgtttaaaa gccggtcttt gtggttcttg 17700 cagatatggc cctcacctgc cgcctccgtt tcccggtgcc gggattccga ggaagaatgc 17760 accgtaggag gggcatggcc ggccacggcc tgacgggcgg catgcgtcgt gcgcaccacc 17820 ggcggcggcg cgcgtcgcac cgtcgcatgc gcggcggtat cctgcccctc cttattccac 17880 tgatcgccgc ggcgattggc gccgtgcccg gaattgcatc cgtggccttg caggcgcaga 17940 gacactgatt aaaaacaagt tgcatgtgga aaaatcaaaa taaaaagtct ggactctcac 18000 gctcgcttgg tcctgtaact attttgtaga atggaagaca tcaactttgc gtctctggcc 18060 ccgcgacacg gctcgcgccc gttcatggga aactggcaag atatcggcac cagcaatatg 18120 agcggtggcg ccttcagctg gggctcgctg tggagcggca ttaaaaattt cggttccacc 18180 gttaagaact atggcagcaa ggcctggaac agcagcacag gccagatgct gagggataag 18240 ttgaaagagc aaaatttcca acaaaaggtg gtagatggcc tggcctctgg cattagcggg 18300 gtggtggacc tggccaacca ggcagtgcaa aataagatta acagtaagct tgatccccgc 18360 cctcccgtag aggagcctcc accggccgtg gagacagtgt ctccagaggg gcgtggcgaa 18420 aagcgtccgc gccccgacag ggaagaaact ctggtgacgc aaatagacga gcctccctcg 18480 tacgaggagg cactaaagca aggcctgccc accacccgtc ccatcgcgcc catggctacc 18540 ggagtgctgg gccagcacac acccgtaacg ctggacctgc ctccccccgc cgacacccag 18600 cagaaacctg tgctgccagg cccgaccgcc gttgttgtaa cccgtcctag ccgcgcgtcc 18660 ctgcgccgcg ccgccagcgg tccgcgatcg ttgcggcccg tagccagtgg caactggcaa 18720 agcacactga acagcatcgt gggtctgggg gtgcaatccc tgaagcgccg acgatgcttc 18780 tgaatagcta acgtgtcgta tgtgtgtcat gtatgcgtcc atgtcgccgc cagaggagct 18840 gctgagccgc cgcgcgcccg ctttccaaga tggctacccc ttcgatgatg ccgcagtggt 18900 cttacatgca catctcgggc caggacgcct cggagtacct gagccccggg ctggtgcagt 18960 ttgcccgcgc caccgagacg tacttcagcc tgaataacaa gtttagaaac cccacggtgg 19020 cgcctacgca cgacgtgacc acagaccggt cccagcgttt gacgctgcgg ttcatccctg 19080 tggaccgtga ggatactgcg tactcgtaca aggcgcggtt caccctagct gtgggtgata 19140 accgtgtgct ggacatggct tccacgtact ttgacatccg cggcgtgctg gacaggggcc 19200 ctacttttaa gccctactct ggcactgcct acaacgccct ggctcccaag ggtgccccaa 19260 atccttgcga atgggatgaa gctgctactg ctcttgaaat aaacctagaa gaagaggacg 19320 atgacaacga agacgaagta gacgagcaag ctgagcagca aaaaactcac gtatttgggc 19380 aggcgcctta ttctggtata aatattacaa aggagggtat tcaaataggt gtcgaaggtc 19440 aaacacctaa atatgccgat aaaacatttc aacctgaacc tcaaatagga gaatctcagt 19500 ggtacgaaac tgaaattaat catgcagctg ggagagtcct taaaaagact accccaatga 19560 aaccatgtta cggttcatat gcaaaaccca caaatgaaaa tggagggcaa ggcattcttg 19620 taaagcaaca aaatggaaag ctagaaagtc aagtggaaat gcaatttttc tcaactactg 19680 aggcgaccgc aggcaatggt gataacttga ctcctaaagt ggtattgtac agtgaagatg 19740 tagatataga aaccccagac actcatattt cttacatgcc cactattaag gaaggtaact 19800 cacgagaact aatgggccaa caatctatgc ccaacaggcc taattacatt gcttttaggg 19860 acaattttat tggtctaatg tattacaaca gcacgggtaa tatgggtgtt ctggcgggcc 19920 aagcatcgca gttgaatgct gttgtagatt tgcaagacag aaacacagag ctttcatacc 19980 agcttttgct tgattccatt ggtgatagaa ccaggtactt ttctatgtgg aatcaggctg 20040 ttgacagcta tgatccagat gttagaatta ttgaaaatca tggaactgaa gatgaacttc 20100 caaattactg ctttccactg ggaggtgtga ttaatacaga gactcttacc aaggtaaaac 20160 ctaaaacagg tcaggaaaat ggatgggaaa aagatgctac agaattttca gataaaaatg 20220 aaataagagt tggaaataat tttgccatgg aaatcaatct aaatgccaac ctgtggagaa 20280 atttcctgta ctccaacata gcgctgtatt tgcccgacaa gctaaagtac agtccttcca 20340 acgtaaaaat ttctgataac ccaaacacct acgactacat gaacaagcga gtggtggctc 20400 ccgggttagt ggactgctac attaaccttg gagcacgctg gtcccttgac tatatggaca 20460 acgtcaaccc atttaaccac caccgcaatg ctggcctgcg ctaccgctca atgttgctgg 20520 gcaatggtcg ctatgtgccc ttccacatcc aggtgcctca gaagttcttt gccattaaaa 20580 acctccttct cctgccgggc tcatacacct acgagtggaa cttcaggaag gatgttaaca 20640 tggttctgca gagctcccta ggaaatgacc taagggttga cggagccagc attaagtttg 20700 atagcatttg cctttacgcc accttcttcc ccatggccca caacaccgcc tccacgcttg 20760 aggccatgct tagaaacgac accaacgacc agtcctttaa cgactatctc tccgccgcca 20820 acatgctcta ccctataccc gccaacgcta ccaacgtgcc catatccatc ccctcccgca 20880 actgggcggc tttccgcggc tgggccttca cgcgccttaa gactaaggaa accccatcac 20940 tgggctcggg ctacgaccct tattacacct actctggctc tataccctac ctagatggaa 21000 ccttttacct caaccacacc tttaagaagg tggccattac ctttgactct tctgtcagct 21060 ggcctggcaa tgaccgcctg cttaccccca acgagtttga aattaagcgc tcagttgacg 21120 gggagggtta caacgttgcc cagtgtaaca tgaccaaaga ctggttcctg gtacaaatgc 21180 tagctaacta caacattggc taccagggct tctatatccc agagagctac aaggaccgca 21240 tgtactcctt ctttagaaac ttccagccca tgagccgtca ggtggtggat gatactaaat 21300 acaaggacta ccaacaggtg ggcatcctac accaacacaa caactctgga tttgttggct 21360 accttgcccc caccatgcgc gaaggacagg cctaccctgc taacttcccc tatccgctta 21420 taggcaagac cgcagttgac agcattaccc agaaaaagtt tctttgcgat cgcacccttt 21480 ggcgcatccc attctccagt aactttatgt ccatgggcgc actcacagac ctgggccaaa 21540 accttctcta cgccaactcc gcccacgcgc tagacatgac ttttgaggtg gatcccatgg 21600 acgagcccac ccttctttat gttttgtttg aagtctttga cgtggtccgt gtgcaccggc 21660 cgcaccgcgg cgtcatcgaa accgtgtacc tgcgcacgcc cttctcggcc ggcaacgcca 21720 caacataaag aagcaagcaa catcaacaac agctgccgcc atgggctcca gtgagcagga 21780 actgaaagcc attgtcaaag atcttggttg tgggccatat tttttgggca cctatgacaa 21840 gcgctttcca ggctttgttt ctccacacaa gctcgcctgc gccatagtca atacggccgg 21900 tcgcgagact gggggcgtac actggatggc ctttgcctgg aacccgcact caaaaacatg 21960 ctacctcttt gagccctttg gcttttctga ccagcgactc aagcaggttt accagtttga 22020 gtacgagtca ctcctgcgcc gtagcgccat tgcttcttcc cccgaccgct gtataacgct 22080 ggaaaagtcc acccaaagcg tacaggggcc caactcggcc gcctgtggac tattctgctg 22140 catgtttctc cacgcctttg ccaactggcc ccaaactccc atggatcaca accccaccat 22200 gaaccttatt accggggtac ccaactccat gctcaacagt ccccaggtac agcccaccct 22260 gcgtcgcaac caggaacagc tctacagctt cctggagcgc cactcgccct acttccgcag 22320 ccacagtgcg cagattagga gcgccacttc tttttgtcac ttgaaaaaca tgtaaaaata 22380 atgtactaga gacactttca ataaaggcaa atgcttttat ttgtacactc tcgggtgatt 22440 atttaccccc acccttgccg tctgcgccgt ttaaaaatca aaggggttct gccgcgcatc 22500 gctatgcgcc actggcaggg acacgttgcg atactggtgt ttagtgctcc acttaaactc 22560 aggcacaacc atccgcggca gctcggtgaa gttttcactc cacaggctgc gcaccatcac 22620 caacgcgttt agcaggtcgg gcgccgatat cttgaagtcg cagttggggc ctccgccctg 22680 cgcgcgcgag ttgcgataca cagggttgca gcactggaac actatcagcg ccgggtggtg 22740 cacgctggcc agcacgctct tgtcggagat cagatccgcg tccaggtcct ccgcgttgct 22800 cagggcgaac ggagtcaact ttggtagctg ccttcccaaa aagggcgcgt gcccaggctt 22860 tgagttgcac tcgcaccgta gtggcatcaa aaggtgaccg tgcccggtct gggcgttagg 22920 atacagcgcc tgcataaaag ccttgatctg cttaaaagcc acctgagcct ttgcgccttc 22980 agagaagaac atgccgcaag acttgccgga aaactgattg gccggacagg ccgcgtcgtg 23040 cacgcagcac cttgcgtcgg tgttggagat ctgcaccaca tttcggcccc accggttctt 23100 cacgatcttg gccttgctag actgctcctt cagcgcgcgc tgcccgtttt cgctcgtcac 23160 atccatttca atcacgtgct ccttatttat cataatgctt ccgtgtagac acttaagctc 23220 gccttcgatc tcagcgcagc ggtgcagcca caacgcgcag cccgtgggct cgtgatgctt 23280 gtaggtcacc tctgcaaacg actgcaggta cgcctgcagg aatcgcccca tcatcgtcac 23340 aaaggtcttg ttgctggtga aggtcagctg caacccgcgg tgctcctcgt tcagccaggt 23400 cttgcatacg gccgccagag cttccacttg gtcaggcagt agtttgaagt tcgcctttag 23460 atcgttatcc acgtggtact tgtccatcag cgcgcgcgca gcctccatgc ccttctccca 23520 cgcagacacg atcggcacac tcagcgggtt catcaccgta atttcacttt ccgcttcgct 23580 gggctcttcc tcttcctctt gcgtccgcat accacgcgcc actgggtcgt cttcattcag 23640 ccgccgcact gtgcgcttac ctcctttgcc atgcttgatt agcaccggtg ggttgctgaa 23700 acccaccatt tgtagcgcca catcttctct ttcttcctcg ctgtccacga ttacctctgg 23760 tgatggcggg cgctcgggct tgggagaagg gcgcttcttt ttcttcttgg gcgcaatggc 23820 caaatccgcc gccgaggtcg atggccgcgg gctgggtgtg cgcggcacca gcgcgtcttg 23880 tgatgagtct tcctcgtcct cggactcgat acgccgcctc atccgctttt ttgggggcgc 23940 ccggggaggc ggcggcgacg gggacgggga cgacacgtcc tccatggttg ggggacgtcg 24000 cgccgcaccg cgtccgcgct cgggggtggt ttcgcgctgc tcctcttccc gactggccat 24060 ttccttctcc tataggcaga aaaagatcat ggagtcagtc gagaagaagg acagcctaac 24120 cgccccctct gagttcgcca ccaccgcctc caccgatgcc gccaacgcgc ctaccacctt 24180 ccccgtcgag gcacccccgc ttgaggagga ggaagtgatt atcgagcagg acccaggttt 24240 tgtaagcgaa gacgacgagg accgctcagt accaacagag gataaaaagc aagaccagga 24300 caacgcagag gcaaacgagg aacaagtcgg gcggggggac gaaaggcatg gcgactacct 24360 agatgtggga gacgacgtgc tgttgaagca tctgcagcgc cagtgcgcca ttatctgcga 24420 cgcgttgcaa gagcgcagcg atgtgcccct cgccatagcg gatgtcagcc ttgcctacga 24480 acgccaccta ttctcaccgc gcgtaccccc caaacgccaa gaaaacggca catgcgagcc 24540 caacccgcgc ctcaacttct accccgtatt tgccgtgcca gaggtgcttg ccacctatca 24600 catctttttc caaaactgca agatacccct atcctgccgt gccaaccgca gccgagcgga 24660 caagcagctg gccttgcggc agggcgctgt catacctgat atcgcctcgc tcaacgaagt 24720 gccaaaaatc tttgagggtc ttggacgcga cgagaagcgc gcggcaaacg ctctgcaaca 24780 ggaaaacagc gaaaatgaaa gtcactctgg agtgttggtg gaactcgagg gtgacaacgc 24840 gcgcctagcc gtactaaaac gcagcatcga ggtcacccac tttgcctacc cggcacttaa 24900 cctacccccc aaggtcatga gcacagtcat gagtgagctg atcgtgcgcc gtgcgcagcc 24960 cctggagagg gatgcaaatt tgcaagaaca aacagaggag ggcctacccg cagttggcga 25020 cgagcagcta gcgcgctggc ttcaaacgcg cgagcctgcc gacttggagg agcgacgcaa 25080 actaatgatg gccgcagtgc tcgttaccgt ggagcttgag tgcatgcagc ggttctttgc 25140 tgacccggag atgcagcgca agctagagga aacattgcac tacacctttc gacagggcta 25200 cgtacgccag gcctgcaaga tctccaacgt ggagctctgc aacctggtct cctaccttgg 25260 aattttgcac gaaaaccgcc ttgggcaaaa cgtgcttcat tccacgctca agggcgaggc 25320 gcgccgcgac tacgtccgcg actgcgttta cttatttcta tgctacacct ggcagacggc 25380 catgggcgtt tggcagcagt gcttggagga gtgcaacctc aaggagctgc agaaactgct 25440 aaagcaaaac ttgaaggacc tatggacggc cttcaacgag cgctccgtgg ccgcgcacct 25500 ggcggacatc attttccccg aacgcctgct taaaaccctg caacagggtc tgccagactt 25560 caccagtcaa agcatgttgc agaactttag gaactttatc ctagagcgct caggaatctt 25620 gcccgccacc tgctgtgcac ttcctagcga ctttgtgccc attaagtacc gcgaatgccc 25680 tccgccgctt tggggccact gctaccttct gcagctagcc aactaccttg cctaccactc 25740 tgacataatg gaagacgtga gcggtgacgg tctactggag tgtcactgtc gctgcaacct 25800 atgcaccccg caccgctccc tggtttgcaa ttcgcagctg cttaacgaaa gtcaaattat 25860 cggtaccttt gagctgcagg gtccctcgcc tgacgaaaag tccgcggctc cggggttgaa 25920 actcactccg gggctgtgga cgtcggctta ccttcgcaaa tttgtacctg aggactacca 25980 cgcccacgag attaggttct acgaagacca atcccgcccg ccaaatgcgg agcttaccgc 26040 ctgcgtcatt acccagggcc acattcttgg ccaattgcaa gccatcaaca aagcccgcca 26100 agagtttctg ctacgaaagg gacggggggt ttacttggac ccccagtccg gcgaggagct 26160 caacccaatc cccccgccgc cgcagcccta tcagcagcag ccgcgggccc ttgcttccca 26220 ggatggcacc caaaaagaag ctgcagctgc cgccgccacc cacggacgag gaggaatact 26280 gggacagtca ggcagaggag gttttggacg aggaggagga ggacatgatg gaagactggg 26340 agagcctaga cgaggaagct tccgaggtcg aagaggtgtc agacgaaaca ccgtcaccct 26400 cggtcgcatt cccctcgccg gcgccccaga aatcggcaac cggttccagc atggctacaa 26460 cctccgctcc tcaggcgccg ccggcactgc ccgttcgccg acccaaccgt agatgggaca 26520 ccactggaac cagggccggt aagtccaagc agccgccgcc gttagcccaa gagcaacaac 26580 agcgccaagg ctaccgctca tggcgcgggc acaagaacgc catagttgct tgcttgcaag 26640 actgtggggg caacatctcc ttcgcccgcc gctttcttct ctaccatcac ggcgtggcct 26700 tcccccgtaa catcctgcat tactaccgtc atctctacag cccatactgc accggcggca 26760 gcggcagcgg cagcaacagc agcggccaca cagaagcaaa ggcgaccgga tagcaagact 26820 ctgacaaagc ccaagaaatc cacagcggcg gcagcagcag gaggaggagc gctgcgtctg 26880 gcgcccaacg aacccgtatc gacccgcgag cttagaaaca ggatttttcc cactctgtat 26940 gctatatttc aacagagcag gggccaagaa caagagctga aaataaaaaa caggtctctg 27000 cgatccctca cccgcagctg cctgtatcac aaaagcgaag atcagcttcg gcgcacgctg 27060 gaagacgcgg aggctctctt cagtaaatac tgcgcgctga ctcttaagga ctagtttcgc 27120 gccctttctc aaatttaagc gcgaaaacta cgtcatctcc agcggccaca cccggcgcca 27180 gcacctgtcg tcagcgccat ttcaactttg tatacaaaag ttgtgatgag caaggaaatt 27240 cccacgccct acatgtggag ttaccagcca caaatgggac ttgcggctgg agctgcccaa 27300 gactactcaa cccgaataaa ctacatgagc gcgggacccc acatgatatc ccgggtcaac 27360 ggaatacgcg cccaccgaaa ccgaattctc ctggaacagg cggctattac caccacacct 27420 cgtaataacc ttaatccccg tagttggccc gctgccctgg tgtaccagga aagtcccgct 27480 cccaccactg tggtacttcc cagagacgcc caggccgaag ttcagatgac taactcaggg 27540 gcgcagcttg cgggcggctt tcgtcacagg gtgcggtcgc ccgggcaggg tataactcac 27600 ctgacaatca gagggcgagg tattcagctc aacgacgagt cggtgagctc ctcgcttggt 27660 ctccgtccgg acgggacatt tcagatcggc ggcgccggcc gctcttcatt cacgcctcgt 27720 caggcaatcc taactctgca gacctcgtcc tctgagccgc gctctggagg cattggaact 27780 ctgcaattta ttgaggagtt tgtgccatcg gtctacttta accccttctc gggacctccc 27840 ggccactatc cggatcaatt tattcctaac tttgacgcgg taaaggactc ggcggacggc 27900 tacgactgaa tgttaagtgg agaggcagag caactgcgcc tgaaacacct ggtccactgt 27960 cgccgccaca agtgctttgc ccgcgactcc ggtgagtttt gctactttga attgcccgag 28020 gatcatatcg agggcccggc gcacggcgtc cggcttaccg cccagggaga gcttgcccgt 28080 agcctgattc gggagtttac ccagcgcccc ctgctagttg agcgggacag gggaccctgt 28140 gttctcactg tgatttgcaa ctgtcctaac cctggattac atcaagatct ttgttgccat 28200 ctctgtgctg agtataataa atacagaaat taaaatatac tggggctcct atcgccatcc 28260 tgtaaacgcc accgtcttca cccgcccaag caaaccaagg cgaaccttac ctggtacttt 28320 taacatctct ccctctgtga tttacaacag tttcaaccca gacggagtga gtctacgaga 28380 gaacctctcc gagctcagct actccatcag aaaaaacacc accctcctta cctgccggga 28440 acgtacgagt gcgtcaccgg ccgctgcacc acacctaccg cctgaccgta aaccagactt 28500 tttccggaca gacctcaata actctgttta ccagaacagg aggtgagctt agaaaaccct 28560 tagggtatta ggccaaaggc gcagctactg tggggtttat gaacaattca agcaactcta 28620 cgggctattc taattcaggt ttctctagaa tcggggttgg ggttattctc tgtcttgtga 28680 ttctctttat tcttatacta acgcttctct gcctaaggct cgccgcctgc tgtgtgcaca 28740 tttgcattta ttgtcagctt tttaaacgct ggggtcgcca cccaagatga ttaggtacat 28800 aatcctaggt ttactcaccc ttgcgtcagc ccacggtacc acccaaaagg tggattttaa 28860 ggagccagcc tgtaatgtta cattcgcagc tgaagctaat gagtgcacca ctcttataaa 28920 atgcaccaca gaacatgaaa agctgcttat tcgccacaaa aacaaaattg gcaagtatgc 28980 tgtttatgct atttggcagc caggtgacac tacagagtat aatgttacag ttttccaggg 29040 taaaagtcat aaaactttta tgtatacttt tccattttat gaaatgtgcg acattaccat 29100 gtacatgagc aaacagtata agttgtggcc cccacaaaat tgtgtggaaa acactggcac 29160 tttctgctgc actgctatgc taattacagt gctcgctttg gtctgtaccc tactctatat 29220 taaatacaaa agcagacgca gctttattga ggaaaagaaa atgccttaat ttactaagtt 29280 acaaagctaa tgtcaccact aactgcttta ctcgctgctt gcaaaacaaa ttcaaaaagt 29340 tagcattata attagaatag gatttaaacc ccccggtcat ttcctgctca ataccattcc 29400 cctgaacaat tgactctatg tgggatatgc tccagcgcta caaccttgaa gtcaggcttc 29460 ctggatgtca gcatctgact ttggccagca cctgtcccgc ggatttgttc cagtccaact 29520 acagcgaccc accctaacag agatgaccaa cacaaccaac gcggccgccg ctaccggact 29580 tacatctacc acaaatacac cccaagtttc tgcctttgtc aataactggg ataacttggg 29640 catgtggtgg ttctccatag cgcttatgtt tgtatgcctt attattatgt ggctcatctg 29700 ctgcctaaag cgcaaacgcg cccgaccacc catctatagt cccatcattg tgctacaccc 29760 aaacaatgat ggaatccata gattggacgg actgaaacac atgttctttt ctcttacagt 29820 atgattaaat gagacatgat tcctcgagtt tttatattac tgacccttgt tgcgcttttt 29880 tgtgcgtgct ccacattggc tgcggtttct cacatcgaag tagactgcat tccagccttc 29940 acagtctatt tgctttacgg atttgtcacc ctcacgctca tctgcagcct catcactgtg 30000 gtcatcgcct ttatccagtg cattgactgg gtctgtgtgc gctttgcata tctcagacac 30060 catccccagt acagggacag gactatagct gagcttctta gaattcttta attatgaaat 30120 ttactgtgac ttttctgctg attatttgca ccctatctgc gttttgttcc ccgacctcca 30180 agcctcaaag acatatatca tgcagattca ctcgtatatg gaatattcca agttgctaca 30240 atgaaaaaag cgatctttcc gaagcctggt tatatgcaat catctctgtt atggtgttct 30300 gcagtaccat cttagcccta gctatatatc cctaccttga cattggctgg aacgcaatag 30360 atgccatgaa ccacccaact ttccccgcgc ccgctatgct tccactgcaa caagttgttg 30420 ccggcggctt tgtcccagcc aatcagcctc gcccaccttc tcccaccccc actgaaatca 30480 gctactttaa tctaacagga ggagatgact gacaccctag atctagaaat ggacggaatt 30540 attacagagc agcgcctgct agaaagacgc agggcagcgg ccgagcaaca gcgcatgaat 30600 caagagctcc aagacatggt taacttgcac cagtgcaaaa ggggtatctt ttgtctggta 30660 aagcaggcca aagtcaccta cgacagtaat accaccggac accgccttag ctacaagttg 30720 ccaaccaagc gtcagaaatt ggtggtcatg gtgggagaaa agcccattac cataactcag 30780 cactcggtag aaaccgaagg ctgcattcac tcaccttgtc aaggacctga ggatctctgc 30840 acccttatta agaccctgtg cggtctcaaa gatcttattc cctttaacta ataaaaaaaa 30900 ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag 30960 cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct 31020 ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt 31080 catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc 31140 atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc 31200 caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt 31260 tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg 31320 caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa 31380 cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc 31440 cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac 31500 cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa 31560 gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac 31620 tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat 31680 ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga 31740 cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca 31800 aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc 31860 aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt 31920 tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc 31980 ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc 32040 caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat 32100 agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc 32160 cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa 32220 actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa 32280 tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga 32340 gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt 32400 ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca 32460 tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga 32520 atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg 32580 atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat 32640 tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact 32700 aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg 32760 ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc 32820 atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat 32880 tgcagaaaat ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat 32940 acagatcacc gtacctcaac tttgtataat aaagttgtaa tcaaactcac agaaccctag 33000 tattcaacct gccacctccc tcccaacaca cagagtacac agtcctttct ccccggctgg 33060 ccttaaaaag catcatatca tgggtaacag acatattctt aggtgttata ttccacacgg 33120 tttcctgtcg agccaaacgc tcatcagtga tattaataaa ctccccgggc agctcactta 33180 agttcatgtc gctgtccagc tgctgagcca caggctgctg tccaacttgc ggttgcttaa 33240 cgggcggcga aggagaagtc cacgcctaca tgggggtaga gtcataatcg tgcatcagga 33300 tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc tccgtcctgc 33360 aggaatacaa catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc 33420 gccttgtcct ccgggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc 33480 agcacagcac cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca 33540 tggcggggac cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc 33600 gacccctcat aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca 33660 cctcccggta ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc 33720 agctggccaa aacctgcccg ccggctatac actgcaggga accgggactg gaacaatgac 33780 agtggagagc ccaggactcg taaccatgga tcatcatgct cgtcatgata tcaatgttgg 33840 cacaacacag gcacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa 33900 ccatatccca gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac 33960 ctcgcacgta actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat 34020 cctccagtat ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg 34080 gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt catgccaaat ggaacgccgg 34140 acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc 34200 cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca 34260 tccaggcgcc ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata 34320 acatccacca ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca 34380 cacacgggag gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt 34440 atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc 34500 aaactctaca gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa 34560 aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc 34620 ctctataaac attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct 34680 caatatatct ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag 34740 agcgccctcc accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca 34800 cagacctgta taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc 34860 cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc 34920 ccgccaggaa ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg 34980 ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg 35040 ctgctcaaaa aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta gtcatgctca 35100 tgcagataaa ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca 35160 aacatgtctg cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat 35220 tagaagcctg tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca 35280 tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct 35340 cggtcatgtc cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg 35400 tcagtgctaa aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca 35460 acattacagc ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac 35520 ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg 35580 cttccacagc ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa 35640 aacaccactc gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag 35700 agcgagtata tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag 35760 aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa 35820 tcgtcacttc cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca 35880 acacatacaa gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg 35940 ccacgtcaca aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat 36000 tattgatgat g 36011 <210> 92 <211> 34235 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO335B-K) <400> 92 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccttatgag 3600 tggaaacgct tcttttaagg ggggagtctt cagcccttat ctgacagggc gtctcccatc 3660 ctgggcagga gttcgtcaga atgttatggg atctactgtg gatggaagac ccgtccaacc 3720 cgccaattct tcaacgctga cctatgctac tttaagttct tcacctttgg acgcagctgc 3780 agccgccgcc gccgcctctg ttgccgctaa cactgtgctt ggaatgggtt actatggaag 3840 tatcgtggct aattccactt cctctaataa cccttctacc ctgactcagg acaagttact 3900 tgtccttttg gcccagctgg aggctttgac ccaacgtctg ggtgaacttt atcagcaggt 3960 ggccgagttg cgagtacaaa ctgagtctgc tgtcggcacg gcaaagtcta aataaaacat 4020 aaataaaaaa ccagactctg tttggatttg gatcaagcaa aatcaagtgt ttttatttca 4080 tttttcgcgc acggtatgcc ctagaccacc gatctcgatc attgagaaca cggtggattt 4140 tttccagaat cctatagagg tgggattgaa tgtttagata catgggcatt aggccatctt 4200 tggggtggag atagctccat tgaagggatt catgctccgg ggtagtgttg taaatcaccc 4260 agtcataaca aggtcgcagt gcatggtgtt gcacaatatc ttttagaagt aggctgattg 4320 ccacagataa gcccttggtg taggtgttta caaaccggtt gagctgggag gggtgcattc 4380 ggggtgaaat tatgtgcatt ttggattgga tttttaagtt ggcaatattg ccgccaagat 4440 ctcgtcttgg gttcatgtta tgaaggacca ccaagacggt gtatccggta catttaggaa 4500 atttatcgtg tagcttggat ggaaaagcgt ggaaaaattt ggagacaccc ttgtgtcctc 4560 cgagattttc catgcactca tccatgataa tagcaatggg gccgtgggca gcagcgcggg 4620 caaacacgtt ccgtgggtct gacacatcat agttatgttc ctgagttaaa tcatcataag 4680 ccattttaat gaatttgggg cggagagtac ccgattgggg tatgaatgtt ccttcgggcc 4740 ccggagcata gttcccctca cagatttgca tttcccaagc tttcagttcc gatggtggaa 4800 tcatgtccac ctggggggct atgaagaaca ccgtttctgg ggcgggggtg attagttggg 4860 atgatagcaa gtttctgagc aattgagatt tgccacatcc ggtggggcca taaatgattc 4920 cgattacagg ttgcaggtgg tagtttaggg aacggcaact gccgtcttct cgaagcaagg 4980 gggccacctc gttcatcatt tcccttacat gcatattttc ccgcaccaaa tccattagga 5040 ggcgctctcc tcctagtgat agaagttctt gtagtgagga aaagtttttc agcggtttta 5100 gaccgtcagc catgggcatt ttggagagag tttgctgcaa aagttctagt ctgttccaca 5160 gttcagtgat gtgttctatg gcatctcgat ccagcagacc tcctcgtttc gcgggtttgg 5220 acggctcctg gagtagggta tgagacgatg ggcgtccagc gctgccaggg ttcggtcctt 5280 ccagggtctc agtgttcgag tcagggttgt ttccgtcaca gtgaaggggt gtgcgcctgc 5340 ttgggcgctt gccagggtgc gcttcagact cattctgctg gtggagaact tctgtcgctt 5400 ggcgccctgt atgtcggcca agtagcagtt taccatgagt tcgtagttga gcgcctcggc 5460 tgcgtggcct ttggcgcgga gcttaccttt ggaagttttc ttgcataccg ggcagtatag 5520 gcatttcagc gcatacagct tgggcgcaag gaaaatggat tctggggagt atgcatctgc 5580 gccgcaggag gcgcaaacag tttcacattc caccagccag gttaaatccg gttcattggg 5640 gtcaaaaaca agttttccgc catatttttt gatgcgtttc ttacctttgg tctccatgag 5700 ttcgtgtcct cgttgagtga caaacaggct gtccgtatcc ccgtagactg attttacagg 5760 cctcttctcc agtggagtgc ctcggtcttc ttcgtacagg aactctgacc actctgatac 5820 aaaggcgcgc gtccaggcca gcacaaagga ggctatgtgg gaggggtagc gatcgttgtc 5880 aaccaggggg tccacctttt ccaaagtatg caaacacatg tcaccctctt caacatccag 5940 gaatgtgatt ggcttgtagg tgtatttcac gtgacctggg gtccccgctg ggggggtata 6000 aaagggggcg gttctttgct cttcctcact gtcttccgga tcgctgtcca ggaacgtcag 6060 ctgttggggt aggtattccc tctcgaaggc gggcatgacc tctgcactca ggttgtcagt 6120 ttctaagaac gaggaggatt tgatattgac agtgccggtt gagatgcctt tcatgaggtt 6180 ttcgtccatt tggtcagaaa acacaatttt tttattgtca agtttggtgg caaatgatcc 6240 atacagggcg ttggataaaa gtttggcaat ggatcgcatg gtttggttct tttccttgtc 6300 cgcgcgctct ttggcagcga tgttgagttg gacatactcg cgtgctaggc acttccattc 6360 ggggaagata gttgtcaatt catctggcac gattctcact tgccaccctc gattatgcaa 6420 ggtaattaaa tccacactgg tggccacctc gcctcgaagg ggttcgttgg tccaacagag 6480 cctacctcct ttcctagaac agaaaggggg aagtgggtct agcataagtt catcgggagg 6540 gtctgcatcc atggtaaaga ttcccggaag taaatcctta tcaaaatagc tgatgggagt 6600 ggggtcatct aaggccattt gccattctcg agctgccagt gcacgctcat atgggttaag 6660 gggactgccc cagggcatgg gatgggtgag tgcagaggca tacatgccac agatgtcata 6720 gacgtagatg ggatcctcaa agatgcctat ataggttgga tagcatcgcc cccctctgat 6780 acttgctcgc acatagtcat atagttcatg tgatggcgct agcaaccccg gacccaagtt 6840 ggtgcgattg ggtttttctg ttctgtagac aatctggcga aagatggcgt gagaattgga 6900 agagatggtg ggtctttgaa aaatgttgaa atgggcatga ggtagaccta cagagtctct 6960 gacaaagtgg gcataagatt cttgaagctt ggttaccagt tcggcggtga caagtacgtc 7020 tagggcgcag tagtcaagtg tttcttgaat gatgtcataa cctggttggt ttttcttttc 7080 ccacagttcg cggttgagaa ggtattcttc gcgatccttc cagtactctt ctagcggaaa 7140 cccgtctttg tctgcacggt aagatcctag catgtagaac tgattaactg ccttgtaagg 7200 gcagcagccc ttctctacgg gtagagagta tgcttgagca gcttttcgca gcgaagcgtg 7260 agtaagggcg aaggtgtctc tgaccatgac tttgagaaat tggtatttga agtccatgtc 7320 gtcacaggct ccctgttccc agagttggaa gtctacccgt ttcttgtagg cggggttggg 7380 caaagcgaaa gtaacatcgt tgaagagaat cttaccggct ctgggcataa aattgcgagt 7440 gatgcggaaa ggctgtggta cttccgctcg attgttgatc acctgggcag ctaggacgat 7500 ctcgtcgaaa ccgttgatgt tgtgtcctac gatgtataat tctatgaaac gcggcgtgcc 7560 tttgacgtga ggtagcttat tgagctcatc aaaggttagg tctgtagggt cagataaggc 7620 gtagtgttcg agagcccatt cgtgcaggtg aggatttgca tgtaggaatg atgaccaaag 7680 atccaccgcc agtgctgttt gtaactggtc ccgatactga cgaaaatgct ggccaattgc 7740 cattttttct ggagtgacac agtagaaggt tctggggtct tgttgccatc gatcccactt 7800 tagtttaatg gctagatcgt gggccatgtt gacgagacgc tcttctcctg agagtttcat 7860 gaccagcatg aaaggaacta gttgtttgcc aaaggacccc atccaggtgt aagtttccac 7920 atcgtaggtc aggaagagtc tttctgtgcg aggatgagag ccgatcggga agaactggat 7980 ttcctgccac cagttggagg attggctgtt gatgtgatgg aagtagaagt ttctgcggcg 8040 cgccgagcat tcgtgtttgt gcttgtacag acggccgcag tagtcgcagc gttgcacggg 8100 ttgtatctcg tgaatgagct gtacctggct tcccttgacg agaaatttca gtgggaagcc 8160 gaggcctggc gattgtatct cgtgctcttc tatattcgct gtatcggcct gttcatcttc 8220 tgtttcggtg gtggtcatgc tgacgagccc ccgcgggagg caagtccaga cctcggcgcg 8280 ggaggggcgg agctgaagga ccagagcgcg caggctggag ctgtccagag tcctgagacg 8340 ctgcggactc aggttagtag gtagggacag aagattaact tgcatgatct tttccagggc 8400 gtgcgggagg ttcagatggt acttgatttc cacaggttcg tttgtagaga tgtcaatggc 8460 ttgcagggtt ccgtgtcctt tgggcgccac taccgtacct ttgttttttc ttttgatcgg 8520 tggtggctct cttgcttctt gcatgctcag aagcgatgac ggggacgcgc gccgggcgga 8580 agcggttgtt ccggacccgg aggcatggct ggtagtggca cgtcggcgcc gcgcacgggc 8640 aggttctggt actgcgctct gagaagactt gcgtgcgcca ccacgcgtcg attgacgtct 8700 tgtatctgac gtctctgggt gaaagctacc ggccccgtga gcttgaacct gaaagagagt 8760 tcaacagaat caatttcggt atcgttaacg gcagcttgtc tcagtatttc ttgtacgtca 8820 ccagagttgt cctggtaggc gatctccgcc atgaactgct cgatttcttc ctcctgaaga 8880 tctccgcgac ccgctctctc gacggtggcc gcgaggtcat tggagatacg gcccatgagt 8940 tgggagaatg cagtcatgcc cgcctcgttc cagacgcggc tgtaaaccac ggccccctcg 9000 gagtctcttg cgcgcatcac cacctgagcg aggttaagct ccacgtgtct ggtgaagacc 9060 gcatagttgc ataggcgctg aaaaaggtag ttgagtgtgg tggcaatgtg ttcggcgacg 9120 aagaaataca tgatccatcg tctcagcggc atttcgctga catcgcccag agcttccaag 9180 cgctccatgg cctcgtagaa gtccacggca aaattaaaaa actgggagtt tcgcgcggac 9240 acggtcaatt cctcctcgag aagacggatg agttcggcta tggtggcccg tacttcgcgt 9300 tcgaaggctc ccgggatctc ttcttcctct tctatctctt cttccactaa catctcttct 9360 tcgtcttcag gcgggggcgg agggggcaca cggcgacgtc gacggcgcac gggcaaacgg 9420 tcgatgaatc gttcaatgac ctctccgcgg cggcggcgca tggtttcagt gacggcgcgg 9480 ccgttctcgc gcggtcgcag agtaaaaaca ccgccgcgca tctccttaaa gtggtgactg 9540 ggaggttctc cgtttgggag ggagagggcg ctgattatac attttattaa ttggcccgta 9600 gggactgcgc gcagagatct gatcgtgtca agatccacgg gatctgaaaa cctttcgacg 9660 aaagcgtcta accagtcaca gtcacaaggt aggctgagta cggcttcttg tgggcggggg 9720 tggttatgtg ttcggtctgg gtcttctgtt tcttcttcat ctcgggaagg tgagacgatg 9780 ctgctggtga tgaaattaaa gtaggcagtt ctaagacggc ggatggtggc gaggagcacc 9840 aggtctttgg gtccggcttg ctggatacgc aggcgattgg ccattcccca agcattatcc 9900 tgacatctag caagatcttt gtagtagtct tgcatgagcc gttctacggg cacttcttcc 9960 tcacccgttc tgccatgcat acgtgtgagt ccaaacccgc gcattggttg taccagtgcc 10020 aagtcagcta cgactctttc ggcgaggatg gcttgctgta cttgggtgag ggtggcttga 10080 aagtcatcaa aatccacaaa gcggtggtaa gccccggtat taatggtgta agcacagttg 10140 gccatgactg accagttaac tgtctggtga ccagggcgca cgagctcggt gtatttaagg 10200 cgcgaatagg cgcgggtgtc aaagatgtaa tcgttgcagg tgcgcaccag atactggtaa 10260 cctataagaa aatgcggcgg tggttggcgg tagagaggcc atcgttctgt agctggagcg 10320 ccgggggcga ggtcttccaa cataaggcgg tgatagccgt agatgtacct ggacatccag 10380 gtgattcctg cggcggtagt agaagcccga ggaaactcgc gtacgcggtt ccaaatgttg 10440 cgtagcggca tgaagtagtt cattgtaggc acggtttgac cagtgaggcg cgcgcagtca 10500 ttgatgctct atagacacgg agaaaatgaa agcgttcagc gactcgactc cgtagcctgg 10560 aggaacgtga acgggttggg tcgcggtgta ccccggttcg agacttgtac tcgagccggc 10620 cggagccgcg gctaacgtgg tattggcact cccgtctcga cccagcctac aaaaatccag 10680 gatacggaat cgagtcgttt tgctggttgc cgaatggcag ggaagtgagt cctatttttt 10740 ttttttgccg ctcagatgca tcccgtgctg cgacagatgc gtccccaaca acagcccccc 10800 tcgcagcagc agcaaccaca aaaggctgtc cctgcaacta ctgcaactgc cgctgtgagc 10860 ggtgcgggac agcccgccta tgatctggac ttggaagagg gcgaaggact ggcacgtcta 10920 ggtgcgcctt cgcccgagcg gcatccgcga gttcaactga aaaaagattc tcgcgaggcg 10980 tatgtgcccc aacagaacct atttagagac agaagcggcg aggagccgga ggagatgcga 11040 gcttcccgct ttaacgcggg tcgtgagctg cgtcacggtt tggacagaag acgagtgttg 11100 cgggacgagg atttcgaagt tgatgaagtg acagggatca gtcctgccag ggcacacgtg 11160 gctgcagcca accttgtatc ggcttacgaa cagacagtaa aggaagagcg taatttccaa 11220 aagtctttta ataatcatgt gcgaaccctc attgcccgcg aagaagtcac ccttggtttg 11280 atgcatttgt gggatttgat ggaagctatc attcagaacc ctactagcaa acctctgacc 11340 gcacagctgt ttctggtggt gcaacacagc agagacaatg aggctttcag agaggcgctg 11400 ctcaacatca ccgaacccga ggggagatgg ttgtatgatc ttatcaacat tctacagagt 11460 atcatagtgc aggagcggag cctgggcctg gccgagaagg tggctgccat caattactcg 11520 gttttgagct tgggaaagta ttacgctcgc aagatctaca agactccata cgttcccata 11580 gacaaggagg tgaagataga tgggttctac atgcgcatga cgctgaaggt gttgaccctg 11640 agcgatgatc ttggggtgta ccgcaatgac agaatgcatc gcgcggtgag cgccagcagg 11700 aggcgcgagt taagcgacag ggaactgatg cacagtttgc aaagagctct aactggagct 11760 ggaaccgagg gtgagaatta ctttgatatg ggagctgact tgcagtggca gcctagtcgc 11820 agggctctga acgccgcgac ggcaggatgt gagcttcctt acatagaaga ggcggatgaa 11880 ggcgaggagg aagagggcga gtacttggaa gactgatggc acaacccgtg ttttttgcta 11940 gatggaacag caagcaccgg atcccgcaat gcgggcggcg ctgcagagcc agccgtccgg 12000 cattaactcc tcggacgatt ggacccaggc catgcaacgt atcatggcgt tgacgactcg 12060 caaccccgaa gcctttagac agcaacccca ggccaaccgt ctatcggcca tcatggaagc 12120 tgtagtgcct tcccgctcta atcccactca tgagaaggtc ctggccatcg tgaacgcgtt 12180 ggtggagaac aaagctattc gtccagatga ggccggactg gtatacaacg ctctcttaga 12240 acgcgtggct cgctacaaca gtagcaatgt gcaaaccaat ttggaccgta tgataacaga 12300 tgtacgcgaa gccgtgtctc agcgcgaaag gttccagcgc gatgccaacc tgggttcgct 12360 ggtggcgtta aatgctttct tgagtactca gcctgctaat gtgccgcgtg gtcaacagga 12420 ttatactaac tttttaagtg ctttgagact gatggtatca gaagtacctc agagcgaagt 12480 atatcagtcc ggtcctgatt acttctttca gactagcaga cagggcttgc agacggtaaa 12540 tctgagccaa gcttttaaaa accttaaagg tttgtgggga gtgcatgccc cggtaggaga 12600 aagagcaacc gtgtctagct tgttaactcc gaactcccgc ctattattac tgttggtagc 12660 tcctttcacc gacagcggta gcatcgaccg taattcctat ttgggttacc tactaaacct 12720 gtatcgcgaa gccatagggc aaagtcaggt ggacgagcag acctatcaag aaattaccca 12780 agtcagtcgc gctttgggac aggaagacac tggcagtttg gaagccactc tgaacttctt 12840 gcttaccaat cggtctcaaa agatccctcc tcaatatgct cttactgcgg aggaggagag 12900 gatccttaga tatgtgcagc agagcgtggg attgtttctg atgcaagagg gggcaactcc 12960 gactgcagca ctggacatga cagcgcgaaa tatggagccc agcatgtatg ccagtaaccg 13020 acctttcatt aacaaactgc tggactactt gcacagagct gccgctatga actctgatta 13080 tttcaccaat gccatcttaa acccgcactg gctgccccca cctggtttct acacgggcga 13140 atatgacatg cccgacccta atgacggatt tctgtgggac gacgtggaca gcgatgtttt 13200 ttcacctctt tctgatcatc gcacgtggaa aaaggaaggc ggcgatagaa tgcattcttc 13260 tgcatcgctg tccggggtca ttggtgctac cgcggctgag cccgagtctg caagtccttt 13320 tcctagtcta cccttttctc tacacagtgt acgtagcagc gaagtgggta gaataagtcg 13380 cccgagttta atgggcgaag aggagtacct aaacgattcc ttgctcagac cggcaagaga 13440 aaaaaatttc ccaaacaatg gaatagaaag tttggtggat aaaatgagta gatggaagac 13500 ttatgctcag gatcacagag acgagcctgg gatcatgggg actacaagta gagcgagccg 13560 tagacgccag cgccatgaca gacagagggg tcttgtgtgg gacgatgagg attcggccga 13620 tgatagcagc gtattggact tgggtgggag aggaaggggc aacccgtttg ctcatttgcg 13680 ccctcgcttg ggtggtatgt tgtaaaaaaa aataaaaaag aaaaaactca ccaaggccat 13740 ggcgacgagc gtacgttcgt tcttctttat tatctgtgtc tagtataatg aggcgagtcg 13800 tgctaggcgg agcggtggtg tatccggagg gtcctcctcc ttcgtacgag agcgtgatgc 13860 agcagcagca ggcgacggcg gtgatgcaat ccccactgga ggctcccttt gtgcctccgc 13920 gatacctggc acctacggag ggcagaaaca gcattcgtta ctcggaactg gcacctcagt 13980 acgataccac caggttgtat ctggtggaca acaagtcggc ggacattgct tctctgaact 14040 atcagaatga ccacagcaac ttcttgacca cggtggtgca aaacaatgac tttaccccta 14100 cggaagccag cacccagacc attaactttg atgaacgatc gcggtggggc ggtcagctaa 14160 aaaccatcat gcatactaac atgcccaacg tgaacgagta tatgtttagt aacaagttca 14220 aagcgcgtgt gatggtgtcc agaaaacctc ctgagggtgt tagagtagac gataattatg 14280 atcataagca agatattcta aaatacgagt ggttcgagtt tactttgcca gaaggcaact 14340 tttcggtcac tatgactatc gacttgatga acaatgccat catagacaat tacttgaaag 14400 tgggcagaca gaatggagtg ttggaaagtg acattggtgt taagttcgac actaggaact 14460 tcaagttggg atgggatcca gaaactaagt tgatcatgcc tggggtttac acctatgagg 14520 ccttccatcc tgacatcgta ttgctgcctg gctgcggagt ggactttacc gaaagccgtc 14580 tgagcaacct tcttggcatt agaaagaaac acccattcca agagggtttt aagatcttgt 14640 atgaggattt agaaggagga aatattccag cccttttgga tgtagatgct tatgagaaca 14700 gcaagaaaga tcaaaaagcc aaaatagaag ctgctgcaga agctaaagca aacatagttg 14760 ccaacgatcc ggtaagggtg gctaacgcta gtgaaatcag gggagacagt tttgccgcaa 14820 catccgttcc gactaaagaa tcattattgg atgatgtgtc tcaaaacata gagttaaaac 14880 tcactattaa gcctgtggaa aaagatggca aaaacagaag ttacaatgtg ttggaagata 14940 aaatcaacac ggcctatcgc agttggtacc tttcgtacaa ttatggcgac cccgaaaaag 15000 gagtgcgttc ctggacattg ctcaccacct cagatgtcac ctgcggagcg gagcaggtct 15060 actggtcgct tccagacatg atgcaggatc ctgtcacttt ccgctccact agacaagtca 15120 gtaactaccc tgtggtgggt gcagagctta tgcccgtctt ttcaaagagc ttctacaacg 15180 aacaagctgt gtactcccag cagctccgcc agtccacctc gcttacgcac gtcttcaacc 15240 gctttcctga gaaccagatt ttaatccgtc cgccggcgcc cacaattacc accgtcagtg 15300 aaaacgttcc tgctctcaca gatcacggga ccctgccgtt gcgcagcagt atccggggag 15360 tccaacgtgt gaccgttact gacgccagac gccgcacctg tccctacgtg tacaaggcac 15420 tgggcatagt cgcaccgcgc gtcctttcaa gccgcacttt ctaaaaaaaa aaaaaaaatg 15480 tccgttctta tctcgcccag taataacacc ggttggggtc tgcgcgctcc cagcaagatg 15540 tacggaggcg cacgcaaacg ttctacccaa catcccgtgc gtgttcgcgg gcattttcgc 15600 gctccatggg gtgccctcaa gggccgcact cgcgttcgaa ccaccgtcga tgatgtaatc 15660 gatcaggtgg ttgccgacgc ccgtaattat actcctactg cgcctacatc tactgtggac 15720 gcagttattg acagtgtagt ggctgacgct cgcaactatg ctcgacgtaa gagccggcga 15780 aggcgcattg ccagacgtca ccgagctacc actgccatgc gagcagcaag agctctgcta 15840 cgaagagcta gacgcgtggg gcgaagagcc atgcttaggg cggccagacg tgcagcttcg 15900 ggcgccagcg ccggcaggtc ccgcaggcaa gcagccgctg tcgcagcggc gactattgcc 15960 gacatggccc aatcgcgaag aggcaatgta tactgggtgc gtgacgctgc caccggtcaa 16020 cgtgtacccg tgcgcacccg tccccctcgc acttagaaga tactgagcag tctccgatgt 16080 tgtgtcccag cggcgaggat gtccaagcgc aaatacaagg aagaaatgct gcaggttatc 16140 gcacctgaag tctacggcca accgttgaag gatgaaaaaa aaccccgcaa aatcaagcgg 16200 gtaaaaaagg acaaaaaaga agaggaagat ggcgatgatg ggctggcgga gtttgtgcgc 16260 gagtttgccc cacggcgacg cgtgcaatgg cgtgggcgca aagttcgaca tgtgttgaga 16320 cctggaactt cggtggtctt tacacccggc gagcgttcaa gcgctacttt taagcgttcc 16380 tatgatgagg tgtacgggga tgatgatatt cttgagcagg cagctgaccg attaggcgag 16440 tttgcttatg gcaagcgtag tagaataaat cccaaggatg aaacagtgtc catacccttg 16500 gatcatggaa atcccacccc tagtcttaaa ccggtcactt tgcagcaagt gttacccgta 16560 actccgcgaa caggtgttaa acgcgaaggt gaagatttgt atcccactat gcaactgatg 16620 gtgcccaaac gccagaagtt ggaggacgtt ttggagaaag taaaagtgga tccagatatt 16680 caacctgagg ttaaagtgag acccattaag caggtagcgc ctggtctggg agtacaaact 16740 gtagacatta aaattcccac tgaaagtatg gaagtgcaaa ctgaacccgc aaagcctact 16800 gccacctcca ctgaagtgca aacggaccca tggatgccca tgcctattac aactgacgcc 16860 gtcggtccca ctcgaagatc ccgacgaaag tacggtccag caagtctgtt gatgcccaac 16920 tatgtcgtac acccatctat tattcctact cctggttacc gaggcactcg ctactatcgc 16980 agccgaaaca gtacttcccg ccgtcgccgc aagacacctg caaatcgcag tcgtcgccgt 17040 agacgcacaa gcaaaccgat tcccggcgcc ctggtgcggc aagtgtaccg caatggtagt 17100 gcggaacctt tgacactgcc gcgtgcgcgt taccatccta gtatcatcac ttaatcaatg 17160 ttgccgctgc ctccttgcag atatggccct cacttgtcgc cttcgcgttc ccatcactgg 17220 ttaccgagga agaaactcgc gccgtagaag agggatgttg gggcgcggaa tgcgacgcta 17280 caggcgacgg cgtgctatcc gcaagcaatt gcggggtggt tttttgccag ccttaattcc 17340 aattatcgct gctgcgattg gcgcaatacc aggcatagct tccgtggcgg ttcaggcctc 17400 gcaacgacat tgacattgga aaaaaaaaaa acgtataaat aaaaaataca atggactctg 17460 acactcctgg tactgtgact atgttttctt agagatggaa gacatcaatt tttcatcctt 17520 ggctccgcga cacggcacga agccgtacat gggcacctgg agcgacatcg gcacgagcca 17580 actgaacggg ggcgccttca attggagcag tatctggagc gggcttaaaa attttggctc 17640 aaccataaaa acatacggga acaaagcttg gaacagcagt acaggacagg cgcttagaaa 17700 taaacttaaa gaccagaact tccaacaaaa agtagtcgat gggatagctt ccggtatcaa 17760 tggagtggta gatttggcta accaggctgt gcagaaaaag ataaacagtc gtttggaccc 17820 gccgccagca accccaggtg aaatgcaagt ggaggaagaa attcctccgc cagaaaaacg 17880 aggcgacaag cgtccgcgtc ccgatttgga agagacgctg gtgacgcgcg tagatgaacc 17940 gccttcttat gaggaagcaa cgaagcttgg aatgcccacc actagaccga tagcccctat 18000 ggccaccggg gtgatgaaac cttctcagtt gcatcgaccc gtcaccttgg atttgccccc 18060 tcctcctgct gctactgctg tacccgcttc taagcctgtc gctgccccga aaccagtcgc 18120 cgtagccagg tcacgtcccg ggggcgctcc tcgtccaaat gcacactggc aaaatactct 18180 gaacagcatc gtgggtctag gcgtgcaaag tgtaaaacgc cgtcgctgct tttaattaaa 18240 tatggagtag cgcttaactt gcctatctgt gtatatgtgt cattacacgc cgtcacagca 18300 tcagaggaaa aaaggaagag gtcgtgcgtc gacgctgagt tactttcaag atggccaccc 18360 catcgatgct gccccaatgg gcatacatgc acatcgccgg acaggatgct tcggagtacc 18420 tgagtccggg tctggtgcag ttcgcccgcg ccacagacac ctacttcaat ctgggaaata 18480 agtttagaaa tcctaccgta gcgccgaccc acgatgtgac caccgatcgt agccagcggc 18540 tcatgttgcg cttcgtgccc gttgaccggg aggacaatac atactcttac aaagtgcggt 18600 acaccctggc cgtgggcgac aacagagtgc tggatatggc cagcacgttc tttgacatta 18660 ggggcgtgtt ggacagaggt cccagtttta aaccctattc tggtacggct tacaactccc 18720 tggctcctaa aggcgctcca aatgcatctc agtggttgga taagggagtt acaagcactg 18780 gcctagtgga cgacggcaat actgatgatg gggaagaagc caaaaaagca acatacactt 18840 ttggtaatgc tccagtaaaa gccgaggctg aaatcacaaa agacggattg ccggtgggct 18900 tggaagtttc aactgaaggt cctaaaccaa tctatgctga taagctttat cagccagaac 18960 ctcaagtggg agacgaaact tggactgacc tagacggaaa aaccgaagag tatggaggga 19020 gggttcttaa acctgaaact aaaatgaaac cctgctacgg atcttttgct aaacctacta 19080 atattaaagg aggtcaggca aaggtaaaac caaaagaaga cgatggcact aacaacatcg 19140 agtatgacat tgacatgaac ttctttgact taagatcaca aagatcagaa ctcaaaccta 19200 aaattgtaat gtatgcagaa aatgtggacc tggaatgtcc agatactcat gttgtgtaca 19260 aacctggagt ttcagatgct agttctgaga ccaatcttgg acaacagtct atgcccaaca 19320 gacccaacta cattggcttc agagataact tcatcggact tatgtactat aacagtactg 19380 gcaacatggg ggtactggct ggccaagcgt ctcagttgaa tgcagtggtt gacttgcagg 19440 acagaaacac agaactgtct taccaactct tgcttgactc tctgggcgac agaaccagat 19500 actttagcat gtggaatcag gctgtggaca gttatgatcc tgatgtacgt gttattgaaa 19560 atcatggtgt ggaagatgaa cttcccaact attgttttcc gttggatggt gtcggtccgc 19620 gaacagatag ttacaaggag attaagccaa atggagacca atctacttgg acaaatgtag 19680 acccaactgg cagcagtgaa cttgctaagg gaaatccatt tgccatggaa attaaccttc 19740 aagccaatct atggcgaagt ttcctttatt ccaatgtggc tctatatctc ccagactcgt 19800 acaaatacac cccgtccaat gtcactcttc cagaaaacaa aaacacctac gactacatga 19860 acgggcgggt ggtgccgcca tctctagtag acacctatgt gaacattggt gccaggtggt 19920 ctctggatgc catggacaat gtcaacccat tcaaccacca ccgtaacgct ggcttgcgtt 19980 accgatccat gcttctgggt aacggacgtt atgtgccttt ccacatacaa gtgcctcaaa 20040 aattcttcgc tgttaaaaac ctgctgcttc tcccaggctc ctacacttat gagtggaact 20100 ttaggaagga tgtaaacatg gttctacaga gttccctcgg taacgaccta cgggtagatg 20160 gcgccagcat cagttttacg agcatcaacc tctatgctac ttttttcccc atggctcaca 20220 acaccgcttc cacccttgaa gccatgctgc ggaatgacac caatgatcag tcattcaacg 20280 actacctatc tgcagctaac atgctctacc ccattcctgc caatgcaacc aatattccca 20340 tttccattcc ttctcgcaac tgggcggctt tcagaggctg gtcatttacc agactgaaaa 20400 ccaaagaaac tccctctttg gggtctggat ttgaccccta cttcgtctat tctggttcta 20460 ttccctacct ggatggtacc ttctacctga accacacttt taagaaggtt tccatcatgt 20520 ttgactcttc agtgagctgg cctggaaatg acaggttact atctcctaac gaatttgaaa 20580 taaagcgcac tgtggatggc gaaggctaca acgtagccca atgcaacatg accaaagact 20640 ggttcttggt acagatgctc gccaactaca acatcggcta tcagggcttc tacattccag 20700 aaggatacaa agatcgcatg tattcatttt tcagaaactt ccagcccatg agcaggcagg 20760 tggttgatga ggtcaattac aaagacttca aggccgtcgc cataccctac caacacaaca 20820 actctggctt tgtgggttac atggctccga ccatgcgtca aggtcaaccc tatcccgcta 20880 actatcccta tccactcatt ggaacaactg ccgtaaatag tgttacgcag aaaaagttct 20940 tgtgtgacag aaccatgtgg cgcataccgt tctcaagcaa cttcatgtct atgggagccc 21000 ttacagactt gggacagaac atgctctatg ccaactcagc tcatgctctg gacatgacct 21060 ttgaggtgga tcccatggat gagcccaccc tgctttatct tctcttcgaa gttttcgacg 21120 tggtcagagt gcatcagcca caccgcggca tcatcgaggc agtctacctg cgtacaccgt 21180 tctcggccgg taacgctacc acgtaagaag cttcttgctt cttgcaaaca gcagctgcaa 21240 ccatggcctg cggatcccaa aacggctcca gcgagcaaga gctcagagcc attgtccaag 21300 acctgggttg cggaccatat tttttgggaa cctttgataa gcgcttcccg gggttcatgg 21360 cccccgataa gctcgcctgt gccattgtaa atacggccgg acgtgagacg gggggagagc 21420 actggttggc tttcggttgg aacccacgtt ctaacacctg ctaccttttt gatccttttg 21480 gattctcgga tgatcgtctc aaacagattt accagtttga atatgagggt ctcctgcgcc 21540 gcagcgctct tgctaccaag gaccggtgta ttacgctgga aaaatctacc cagaccgtgc 21600 agggcccccg ttctgccgcc tgcggacttt tctgctgcat gttccttcat gcctttgtgc 21660 actggcctga ccgtcccatg gacggaaacc ccaccatgaa attgctaact ggagtgccaa 21720 acaacatgct tcattctcct aaagtccagc ccaccctgtg tgacaatcaa aaagcactct 21780 accattttct caatacccat tcgccttatt ttcgctctca tcgtacacac atcgaaaggg 21840 ccactgcgtt cgaccgtatg gatgtgcaat aatgattcat gtaaacaacg tgttcaataa 21900 acagcacttt attttttaca tgtatcgagg ctctggatta cttatttatt tacaagtcga 21960 atgggttctg acgagaatca gaatgacccg caggcagtga tacgttgcgg aactgatact 22020 tgggttgcca cttgaattcg ggaatcacca acttgggaac cggtatatcg ggcaggatgt 22080 cactccacag ctttctggtc agctgcaaag ctcccagcag gtcaggagcc gaaatcttga 22140 aatcacaatt aggaccagtg ctctgagcgc gagagttgcg gtacaccgga ttgcagcact 22200 gaaacaccat cagcgacgga tgtcttacgc ttgccagcac ggtgggatct gcaatcatgc 22260 ccacatccag atcttcagca ttggcaatgc tgaacggggt catcttgcag gtctgcctac 22320 ccatggcggg cacccaatta ggcttgtggt tacaatcgca gtgcaggggg atcagtatca 22380 tcttggcctg atcctgtctg attcctggat acacggctct catgaaagca tcatattgct 22440 tgaaagcctg ctgggcttta ctaccctcgg tataaaacat cccgcaggac ctgctcgaaa 22500 actggttagc tgcgcagccg gcatcattca cacagcagcg ggcgtcattg ttggctattt 22560 gcaccacact tctgccccag cggttttggg tgattttggt tcgctcggga ttctccttca 22620 aggctcgttg tccgttctcg ctggccacat ccatctcgat aatctgctcc ttctgaatca 22680 taatattgcc atgcaagcac ttcagcttgc cctcataatc attgcagcca tgaggccaca 22740 acgcacagcc tgtacattcc caattatggt gggcgatctg agaaaaagaa tgtatcattc 22800 cctgcagaaa tcttcccatc atcgtgctca gtgtcttgtg actagtgaaa gttaactgga 22860 tgcctcggtg ctcctcgttc acgtactggt gacagatgcg cttgtattgt tcgtgctgct 22920 caggcattag tttaaaagag gttctaagtt cgttatccag cctgtacttc tccatcagca 22980 gacacatcac ttccatgcct ttctcccaag cagacaccag gggcaagcta atcggattct 23040 taacagtgca ggcagcagct cctttagcca gagggtcatc tttggcgatc ttctcaatgc 23100 ttcttttgcc atccttctca acgatgcgca cgggcgggta gctgaaaccc actgctacaa 23160 gttgcgcctc ttctctttct tcttcgctgt cttgactgat gtcttgcatg gggacatgtt 23220 tggtcttcct tggcttcttt ttcgggggta tcggaggagg aggactgtcg ctccgttccg 23280 gagacaggga ggattgtgac gtttcgctca ccattaccaa ctgactgtcg gtagaagaac 23340 ctgaccccac acggcgacag gtgtttctct tcgggggcag aggtggaggc gattgcgaag 23400 ggctgcggtc cgacctggaa ggcggatgac tggcagaacc ccttccgcgt tcgggggtgt 23460 gctccctgtg gcggtcgctt aactgatttc cttcgcggct ggccattgtg ttctcctagg 23520 cagagaaaca acagacatgg aaactcagcc attgctgtca acatcgccac gagtgccatc 23580 acatctcgtc ctcagcgacg aggaaaagga gcagagctta agcattccac cgcccagtcc 23640 tgccaccacc tctaccctag aagataagga ggtcgacgca tctcatgaca tgcagaataa 23700 aaaagcgaaa gagtctgagc cagacatcga acaagacccg ggctatgtga caccggtgga 23760 acacgaggaa gagttgaaac gctttctaga gagagaggat gaaaactgcc caaaacagca 23820 agcggataac tatcaccaag atgctggaaa tagggatcag aacaccgact acctcatagg 23880 gcttgacggg gaagacgcgc tccttaaaca tctagcaaga cagtcactca tagtcaagga 23940 tgcattattg gacagaactg aagtgcccat cagtgtcgaa gagctcagcc gcgcctacga 24000 gcttaaccta ttttcacctc gtactccccc caaacgtcag ccaaacggca cctgcgagcc 24060 aaatcctcgc ttaaactttt atccagcttt tgctgtgcca gaagtactgg ctacctatca 24120 catctttttt aaaaatcaaa aaattccagt ctcctgccgc gctaatcgca cccgcgccga 24180 tgccctactc aatctgggac ctggttcacg cttacctgat atagcttcct tggaagaggt 24240 tccaaagatc ttcgagggtc tgggcaataa tgagactcgg gccgcaaatg ctctgcaaaa 24300 gggagaaaat ggcatggatg agcatcacag cgttctggtg gaattggaag gcgataatgc 24360 cagactcgca gtactcaagc gaagcgtcga ggtcacacac tttgcatacc ccgctgtcaa 24420 cctgccccct aaagtcatga cggccgtcat ggaccagtta ctcattaagc gcgcaagtcc 24480 cctttcagaa gacatgcatg acccagatgc ctgtgatgag ggtaaaccag tggtcagtga 24540 tgagcagcta acccgatggc tgggcaccga ctctccccgg gatttggaag agcgtcgcaa 24600 gcttatgatg gccgtggtgc tggttaccgt agaactagag tgtcttcggc gtttctttac 24660 cgattcagaa accttgcgca aactcgaaga gaatctgcac tacactttta gacacggctt 24720 tgtgcggcag gcatgcaaga tatctaacgt ggaactcacc aacctggttt cctacatggg 24780 tattctgcat gagaatcgcc taggacaaag cgtgctgcac agcaccctta agggggaagc 24840 ccgccgtgat tacatccgcg attgtgttta tctctacctg tgccacacgt ggcaaaccgg 24900 catgggtgta tggcagcaat gtttagaaga acagaacctg aaagagctaa acaagctctt 24960 acagaaatct cttaaggttc tgtggacagg gttcgacgag cgcaccgtcg cttccgacct 25020 ggcagacctc atcttcccag agcgtctcag ggttactttg cgaaacggac tgcctgactt 25080 tatgagccag agcatgctta acaattttcg ctctttcatc ctggaacgct ccggtatcct 25140 gcccgccacc tgctgcgcac tgccctccga ctttgtgcct ctcacctacc gcgaatgccc 25200 cccgccgcta tggagtcact gctacctgtt ccgtctggcc aactacctct cctaccactc 25260 ggatgtgatc gaggatgtga gcggagacgg cttgctggag tgtcactgcc gctgcaatct 25320 gtgcacgccc caccggtccc tagcttgcaa cccccagttg atgagcgaaa cccagataat 25380 aggcaccttt gaattgcaag gccccagcag ccaaggcgat gggtcttctc ctgggcaaag 25440 tttaaaactg accccgggac tgtggacctc cgcctacttg cgcaagtttg ccccggaaga 25500 ttaccacccc tatgaaatca agttctatga ggaccaatca cagcctccga aagccgaact 25560 ttcggcctgc gtcatcaccc agggggcaat tctggcccaa ttgcaagcca tccaaaaatc 25620 ccgccaagaa tttctactga aaaagggtaa gggggtctac cttgaccccc agaccggcga 25680 ggaactcaac acaaggttcc ctcaggatgt cccaacgacg agaaagcaag aagttgaagg 25740 tgcagccgcc gcccccagaa gatatggagg aagattggga cagtcaggca gaggaagcgg 25800 aggaggagga cagtctggag gacagtctgg aggaagacag tttggaggag gaaaacgagg 25860 aggcagagga ggtggaagaa gtaaccgccg acaaacagtt atcctcggct gcggagacaa 25920 gcaacagcgc taccatctcc gctccgagtc gaggaacccg gcggcgtccc agcagtagat 25980 gggacgagac cggacgcttc ccgaacccaa ccagcgcttc caagaccggt aagaaggatc 26040 ggcagggata caagtcctgg cgggggcata agaatgccat catctcctgc ttgcatgagt 26100 gcgggggcaa catatccttc acgcggcgct acttgctatt ccaccatggg gtgaactttc 26160 cgcgcaatgt tttgcattac taccgtcacc tccacagccc ctactatagc cagcaaatcc 26220 cggcagtctc gacagataaa gacagcggcg gcgacctcca acagaaaacc agcagcggca 26280 gttagaaaat acacaacaag tgcagcaaca ggaggattaa agattacagc caacgagcca 26340 gcgcaaaccc gagagttaag aaatcggatc tttccaaccc tgtatgccat cttccagcag 26400 agtcggggcc aagagcagga actgaaaata aaaaaccgat ctctgcgttc gctcaccaga 26460 agttgtttgt atcacaagag cgaagatcaa cttcagcgca ctctcgagga cgccgaggct 26520 ctcttcaaca agtactgcgc gctgactctt aaagagtagg cagcgaccgc gcttattcaa 26580 aaaaggcggg aattacatca tcctcgacat gagtaaagaa attcccacgc cttacatgtg 26640 gagttatcag ccccaaatgg gattggcggc aggcgcctcc caggactact ccacccgcat 26700 gaattggctc agcgccgggc cttctatgat ttctcgagtt aatgatatac gcgcctaccg 26760 aaaccaaata cttttggaac agtcagctct taccaccacg ccccgccaac accttaatcc 26820 cagaaattgg cccgccgccc tagtgtacca ggaaagtccc gctcccacca ctgtattact 26880 tcctcgagac gcccaggccg aagtccaaat gactaatgca ggtgcgcagt tagcgggcgg 26940 ctccacccta tgtcgtcaca ggcctcggca taatataaaa cgcctgatga tcagaggccg 27000 aggtatccag ctcaacgacg agtcggtgag ctctccgctt ggtctacgac cagacggaat 27060 ctttcagatt gccggctgcg ggagatcttc cttcacccct cgtcaggctg ttctgacttt 27120 ggaaagttcg tcttcgcaac cccgctcggg cggaatcggg accgttcaat ttgtggagga 27180 gtttactccc tctgtctact tcaacccctt ctccggatct cctgggcact acccggacga 27240 gttcataccg aacttcgacg cgattagcga gtcagtggac ggctacgatt gagtttatgt 27300 taagtggaga ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc cgccacaagt 27360 gctttgcccg cgactccggt gagttttgct actttgaatt gcccgaggat catatcgagg 27420 gcccggcgca cggcgtccgg cttaccgccc agggagagct tgcccgtagc ctgattcggg 27480 agtttaccca gcgccccctg ctagttgagc gggacagggg accctgtgtt ctcactgtga 27540 tttgcaactg tcctaaccct ggattacatc aagatctttg ttgccatctc tgtgctgagt 27600 ataataaata cagaaattaa aatatactgg ggctcctatc gccatcctgt aaacgccacc 27660 gtcttcaccc gcccaagcaa accaaggcga accttacctg gtacttttaa catctctccc 27720 tctgtgattt acaacagttt caacccagac ggagtgagtc tacgagagaa cctctccgag 27780 ctcagctact ccatcagaaa aaacaccacc ctccttacct gccgggaacg tacgagtgcg 27840 tcaccggccg ctgcaccaca cctaccgcct gaccgtaaac cagacttttt ccggacagac 27900 ctcaataact ctgtttacca gaacaggagg tgagcttaga aaacccttag ggtattaggc 27960 caaaggcgca gctactgtgg ggtttatgaa caattcaagc aactctacgg gctattctaa 28020 ttcaggtttc tctagaatcg gggttggggt tattctctgt cttgtgattc tctttattct 28080 tatactaacg cttctctgcc taaggctcgc cgcctgctgt gtgcacattt gcatttattg 28140 tcagcttttt aaacgctggg gtcgccaccc aagatgatta ggtacataat cctaggttta 28200 ctcacccttg cgtcagccca cggtaccacc caaaaggtgg attttaagga gccagcctgt 28260 aatgttacat tcgcagctga agctaatgag tgcaccactc ttataaaatg caccacagaa 28320 catgaaaagc tgcttattcg ccacaaaaac aaaattggca agtatgctgt ttatgctatt 28380 tggcagccag gtgacactac agagtataat gttacagttt tccagggtaa aagtcataaa 28440 acttttatgt atacttttcc attttatgaa atgtgcgaca ttaccatgta catgagcaaa 28500 cagtataagt tgtggccccc acaaaattgt gtggaaaaca ctggcacttt ctgctgcact 28560 gctatgctaa ttacagtgct cgctttggtc tgtaccctac tctatattaa atacaaaagc 28620 agacgcagct ttattgagga aaagaaaatg ccttaattta ctaagttaca aagctaatgt 28680 caccactaac tgctttactc gctgcttgca aaacaaattc aaaaagttag cattataatt 28740 agaataggat ttaaaccccc cggtcatttc ctgctcaata ccattcccct gaacaattga 28800 ctctatgtgg gatatgctcc agcgctacaa ccttgaagtc aggcttcctg gatgtcagca 28860 tctgactttg gccagcacct gtcccgcgga tttgttccag tccaactaca gcgacccacc 28920 ctaacagaga tgaccaacac aaccaacgcg gccgccgcta ccggacttac atctaccaca 28980 aatacacccc aagtttctgc ctttgtcaat aactgggata acttgggcat gtggtggttc 29040 tccatagcgc ttatgtttgt atgccttatt attatgtggc tcatctgctg cctaaagcgc 29100 aaacgcgccc gaccacccat ctatagtccc atcattgtgc tacacccaaa caatgatgga 29160 atccatagat tggacggact gaaacacatg ttcttttctc ttacagtatg attaaatgag 29220 acatggccgt tcagctggtg gaaagtggcg ggggttctgt tcaggcgggc gggtctctga 29280 ggcttacttg cgccgcgagt ggtagaacca gtcggagcta cggaatgggg tggtttaggc 29340 aagctcccgg gaaagaacgc gaatttgtga gcggcattag ctggcggggc gattccactg 29400 ggtacgcaga ctctgtaaag ggaaggttta ccatcagccg cgataacgca aagaacaccg 29460 ttgatctgca gatgaatagc ttgagaccgg aggacaccgc catctactac tgtgcagctg 29520 ccgccggaag cacatggtat gggactctgt atgaatacga ctactggggc cagggtacac 29580 aagttaccgt aagcagcggc tctgggtccg gctcgaccgg agtgcaggtg gaaaccatct 29640 ccccaggaga cgggcgcacc ttccccaagc gcggccagac ctgcgtggtg cactacaccg 29700 ggatgcttga agatggaaag aaatttgatt cctcccggga cagaaacaag ccctttaagt 29760 ttatgctagg caagcaggag gtgatccgag gctgggaaga aggggttgcc cagatgagtg 29820 tgggtcagag agccaaactg actatatctc cagattatgc ctatggtgcc actgggcacc 29880 caggcatcat cccaccacat gccactctcg tcttcgatgt ggagcttcta aaactgtaat 29940 aaaaaaaaat aataaagctt aatcacttac ttgaaatcag caataaggtc tctgttgaaa 30000 ttttctccca gcagcacctc acttccctct tcccaactct ggtattctaa accccgttca 30060 gcggcatact ttctccatac tttaaagggg atgtcaaatt ttagctcctc tcctgtaccc 30120 acaatcttca tgtctttctt cccagatgac caagagagtc cggctcagtg actccttcaa 30180 ccctgtctac ccctatgaag atgaaagcac ctcccaacac ccctttataa acccagggtt 30240 tatttcccca aatggcttca cacaaagccc agacggagtt cttactttaa aatgtttaac 30300 cccactaaca accacaggcg gatctctaca gctaaaagtg ggagggggac ttacagtgga 30360 tgacactgat ggtaccttac aagaaaacat acgtgctaca gcacccatta ctaaaaataa 30420 tcactctgta gaactatcca ttggaaatgg attagaaact caaaacaata aactatgtgc 30480 caaattggga aatgggttaa aatttaacaa cggtgacatt tgtataaagg atagtattaa 30540 caccttatgg accacaccag ctccatctcc taactgtaga ctaaatgcag agaaagatgc 30600 taaactcact ttggtcttaa caaaatgtgg cagtcaaata cttgctacag tttcagtttt 30660 ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt caaagtgctc atcttattat 30720 aagatttgac gaaaatggag tgctactaaa caattccttc ctggacccag aatattggaa 30780 ctttagaaat ggagatctta ctgaaggcac agcctataca aacgctgttg gatttatgcc 30840 taacctatca gcttatccaa aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca 30900 agtttactta aacggagaca aaactaaacc tgtaacacta accattacac taaacggtac 30960 acaggaaaca ggagacacaa ctgagatgtg gcatgaaggc ctagaagagg cctctcgctt 31020 gtactttggg gagaggaacg tcaaaggcat gtttgaggtg ctggagcccc tgcatgctat 31080 gatggaacgc ggtccccaga ccctgaagga aacgtccttt aatcaggcat atggtcgaga 31140 tttaatggag gcacaagaat ggtgccgaaa gtacatgaaa tcagggaacg tcaaggacct 31200 cctccaagcc tgggacctct actatcacgt gttcagacga atctcaaagc agccaagtgc 31260 atactctatg tcattttcat gggactggtc tggccacaac tacattaatg aaatatttgc 31320 cacatcctct tacacttttt catacattgc ccaagaataa taaagaatcg tttgtgttat 31380 gtttcaacgt gtttattttt caattgcaga aaatttcgaa tcatttttca ttcagtagta 31440 tagccccacc accacatagc ttatacagat caccgtacct taatcaaacc tacatggggg 31500 tagagtcata atcgtgcatc aggatagggc ggtggtgctg cagcagcgcg cgaataaact 31560 gctgccgccg ccgctccgtc ctgcaggaat acaacatggc agtggtctcc tcagcgatga 31620 ttcgcaccgc ccgcagcata aggcgccttg tcctccgggc acagcagcgc accctgatct 31680 cacttaaatc agcacagtaa ctgcagcaca gcaccacaat attgttcaaa atcccacagt 31740 gcaaggcgct gtatccaaag ctcatggcgg ggaccacaga acccacgtgg ccatcatacc 31800 acaagcgcag gtagattaag tggcgacccc tcataaacac gctggacata aacattacct 31860 cttttggcat gttgtaattc accacctccc ggtaccatat aaacctctga ttaaacatgg 31920 cgccatccac caccatccta aaccagctgg ccaaaacctg cccgccggct atacactgca 31980 gggaaccggg actggaacaa tgacagtgga gagcccagga ctcgtaacca tggatcatca 32040 tgctcgtcat gatatcaatg ttggcacaac acaggcacac gtgcatacac ttcctcagga 32100 ttacaagctc ctcccgcgtt agaaccatat cccagggaac aacccattcc tgaatcagcg 32160 taaatcccac actgcaggga agacctcgca cgtaactcac gttgtgcatt gtcaaagtgt 32220 tacattcggg cagcagcgga tgatcctcca gtatggtagc gcgggtttct gtctcaaaag 32280 gaggtagacg atccctactg tacggagtgc gccgagacaa ccgagatcgt gttggtcgta 32340 gtgtcatgcc aaatggaacg ccggacgtag tcatatttcc tgaagcaaaa ccaggtgcgg 32400 gcgtgacaaa cagatctgcg tctccggtct cgccgcttag atcgctctgt gtagtagttg 32460 tagtatatcc actctctcaa agcatccagg cgccccctgg cttcgggttc tatgtaaact 32520 ccttcatgcg ccgctgccct gataacatcc accaccgcag aataagccac acccagccaa 32580 cctacacatt cgttctgcga gtcacacacg ggaggagcgg gaagagctgg aagaaccatg 32640 tttttttttt tattccaaaa gattatccaa aacctcaaaa tgaagatcta ttaagtgaac 32700 gcgctcccct ccggtggcgt ggtcaaactc tacagccaaa gaacagataa tggcatttgt 32760 aagatgttgc acaatggctt ccaaaaggca aacggccctc acgtccaagt ggacgtaaag 32820 gctaaaccct tcagggtgaa tctcctctat aaacattcca gcaccttcaa ccatgcccaa 32880 ataattctca tctcgccacc ttctcaatat atctctaagc aaatcccgaa tattaagtcc 32940 ggccattgta aaaatctgct ccagagcgcc ctccaccttc agcctcaagc agcgaatcat 33000 gattgcaaaa attcaggttc ctcacagacc tgtataagat tcaaaagcgg aacattaaca 33060 aaaataccgc gatcccgtag gtcccttcgc agggccagct gaacataatc gtgcaggtct 33120 gcacggacca gcgcggccac ttccccgcca ggaaccatga caaaagaacc cacactgatt 33180 atgacacgca tactcggagc tatgctaacc agcgtagccc cgatgtaagc ttgttgcatg 33240 ggcggcgata taaaatgcaa ggtgctgctc aaaaaatcag gcaaagcctc gcgcaaaaaa 33300 gaaagcacat cgtagtcatg ctcatgcaga taaaggcagg taagctccgg aaccaccaca 33360 gaaaaagaca ccatttttct ctcaaacatg tctgcgggtt tctgcataaa cacaaaataa 33420 aataacaaaa aaacatttaa acattagaag cctgtcttac aacaggaaaa acaaccctta 33480 taagcataag acggactacg gccatgccgg cgtgaccgta aaaaaactgg tcaccgtgat 33540 taaaaagcac caccgacagc tcctcggtca tgtccggagt cataatgtaa gactcggtaa 33600 acacatcagg ttgattcaca tcggtcagtg ctaaaaagcg accgaaatag cccgggggaa 33660 tacatacccg caggcgtaga gacaacatta cagcccccat aggaggtata acaaaattaa 33720 taggagagaa aaacacataa acacctgaaa aaccctcctg cctaggcaaa atagcaccct 33780 cccgctccag aacaacatac agcgcttcca cagcggcagc cataacagtc agccttacca 33840 gtaaaaaaga aaacctatta aaaaaacacc actcgacacg gcaccagctc aatcagtcac 33900 agtgtaaaaa agggccaagt gcagagcgag tatatatagg actaaaaaat gacgtaacgg 33960 ttaaagtcca caaaaaacac ccagaaaacc gcacgcgaac ctacgcccag aaacgaaagc 34020 caaaaaaccc acaacttcct caaatcgtca cttccgtttt cccacgttac gtcacttccc 34080 attttaagaa aactacaatt cccaacacat acaagttact ccgccctaaa acctacgtca 34140 cccgccccgt tcccacgccc cgcgccacgt cacaaactcc accccctcat tatcatattg 34200 gcttcaatcc aaaataaggt atattattga tgatg 34235 <210> 93 <211> 34362 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO159X) <400> 93 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccttaatga 3600 gtggaaacgc ttcttttaag gggggagtct tcagccctta tctgacaggg cgtctcccat 3660 cctgggcagg agttcgtcag aatgttatgg gatctactgt ggatggaaga cccgtccaac 3720 ccgccaattc ttcaacgctg acctatgcta ctttaagttc ttcacctttg gacgcagctg 3780 cagctgccgc cgccgcttct gttgccgcta acactgtgct tggaatgggt tactatggaa 3840 gcatcatggc taattccact tcctctaata acccttctac cctgactcag gacaagttac 3900 ttgtcctttt ggcccagctg gaggctttga cccaacgtct gggtgaactt tctcagcagg 3960 tggtcgagtt gcgagtacaa actgagtctg ctgtcggcac ggcaaagtct aaataaaaca 4020 taaataaaaa accagactct gtttggattt ggatcaagca agtaaatcaa gtgtttttat 4080 ttcatttttc gcgcacggta tgccctagac caccgatctc tatcattgag aactcggtgg 4140 attttttcca ggatcctata gaggtgggat tgaatgttta gatacatggg cattaggccg 4200 tctttggggt ggagatagct ccattgaagg gattcatgct ccggggtagt gttgtaaatc 4260 acccagtcat aacaaggtcg cagtgcatgg tgttgcacaa tatcttttag aagtaggctg 4320 attgccacag ataagccctt ggtgtaggtg tttacaaacc ggttgagctg ggatgggtgc 4380 attcggggtg aaattatgtg cattttggat tggattttta agttggcaat attgccgcca 4440 agatcccgtc ttgggttcat gttatgaagg accaccaaga cggtgtatcc ggtacattta 4500 ggaaatttat cgtgcagctt ggatggaaaa gcgtggaaaa atttggagac acccttgtgt 4560 cctccaagat tttccatgca ctcatccatg ataatagcaa tggggccgtg ggcagcggcg 4620 cgggcaaaca cgttccgtgg gtctgacaca tcatagttat gttcctgagt taaatcatca 4680 taagccattt taatgaattt ggggcggaga gtaccagatt ggggtatgaa tgttccttcg 4740 ggccccggag catagttccc ctcacagatt tgcatttccc aagctttcag ttccgagggt 4800 ggaatcatgt ccacctgggg ggctatgaaa aacaccgttt ctggggcggg ggtgattaat 4860 tgtgatgata gcaaatttct gagcaattga gatttgccac atccggtggg gccataaatg 4920 attccgatta cgggttgcag gtggtagttt agggaacggc aactgccgtc ttctcgaagc 4980 aagggggcca cctcgttcat catttccctt acatgcatat tttcccgcac caaatccatt 5040 aggaggcgct ctcctcctag tgatagaagt tcttgtagtg aggaaaagtt tttcagcggt 5100 ttcagaccgt cagccatggg cattttggag agagtttgct gcaaaagttc tagtctgttc 5160 cacagttcag tgatgtgttc tatggcatct cgatccagca gacctcctcg tttcgcgggt 5220 ttggacggct cctggaatag ggtatgagac gatgggcgtc cagcgctgcc agggttcggt 5280 ccttccaggg tctcagtgtt cgagtcaggg ttgtttccgt cacagtgaag gggtgtgcgc 5340 ctgcttgggc gcttgccagg gtgcgcttca gactcatcct gctggtcgaa aacttctgtc 5400 gcttggcgcc ctgtatgtcg gccaagtagc agtttaccat gagttcgtag ttgagcgcct 5460 cggctgcgtg gcctttggcg cggagcttac ctttggaagt tttcttgcat accgggcagt 5520 ataggcattt cagcgcatac aacttgggcg caaggaaaac ggattctggg gagtatgcat 5580 ctgcgccgca ggaggcgcaa acagtttcac attccaccag ccaggttaaa tccggttcat 5640 tggggtcaaa aacaagtttt ccgccatatt ttttgatgcg tttcttacct ttggtctcca 5700 tgagttcgtg tcctcgttga gtgacaaaca ggctgtccgt gtccccgtag actgatttta 5760 caggcctctt ctccagtgga gtgcctcggt cttcttcgta caggaactct gaccactctg 5820 atacaaaggc gcgcgtccag gccagcacaa aggaggctat gtgggagggg tagcgatcgt 5880 tgtcaaccag ggggtccacc ttttccaaag tatgcaaaca catgtcaccc tcttcaacat 5940 ccaggaatgt gattggcttg taggtgtatt tcacgtgacc tggggtcccc gctggggggg 6000 tataaaaggg ggcggttctt tgctcttcct cactgtcttc cggatcgctg tccaggaacg 6060 tcagctgttg gggtaggtat tccctctcga aggcgggcat gacctctgca ctcaggttgt 6120 cagtttctaa gaacgaggag gatttgatat tgacagtgcc ggttgagatg cctttcatga 6180 ggttttcgtc catttggtca gaaaacacaa tttttttatt gtcaagtttg gtggcaaatg 6240 atccatacag ggcgttggat aaaagtttgg caatggatcg catggtttgg ttcttttcct 6300 tgtccgcgcg ctctttggcg gcgatgttga gttggacata ctcgcgtgcc aggcacttcc 6360 attcggggaa gatagttgtt aattcatctg gcacgattct cacttgccac cctcgattat 6420 gcaaggtaat taaatccaca ctggtggcca cctcgcctcg aaggggttca ttggtccaac 6480 agagcctacc tcctttccta gaacagaaag ggggaagtgg gtctagcata agttcatcgg 6540 gagggtctgc atccatggta aagattcccg gaagtaaatc cttatcaaaa tagctgatgg 6600 gagtggggtc atctaaggcc atttgccatt ctcgagctgc cagtgcgcgc tcatatgggt 6660 taaggggact gccccatggc atgggatggg tgagtgcaga ggcatacatg ccacagatgt 6720 catagacgta gatgggatcc tcaaagatgc ctatgtaggt tggatagcat cgcccccctc 6780 tgatacttgc tcgcacatag tcatatagtt catgtgatgg cgctagcagc cccggaccca 6840 agttggtgcg attgggtttt tctgttctgt agacgatctg gcgaaagatg gcgtgagaat 6900 tggaagagat ggtgggtctt tgaaaaatgt tgaaatgggc atgaggtaga cctacagagt 6960 ctctgacaaa gtgggcataa gattcttgaa gcttggttac cagttcggcg gtgacaagta 7020 cgtctagggc gcagtagtca agtgtttctt gaatgatgtc ataacctggt tggtttttct 7080 tttcccacag ttcgcggttg agaaggtatt cttcgcgatc cttccagtac tcttctagcg 7140 gaaacccgtc tttgtctgca cggtaagatc ctagcatgta gaactgatta actgccttgt 7200 aagggcagca gcccttctct acgggtagag agtatgcttg agcagctttt cgtagcgaag 7260 cgtgagtaag ggcaaaggtg tctctgacca tgactttgag aaattggtat ttgaagtcga 7320 tgtcgtcaca ggctccctgt tcccagagtt ggaagtctac ccgtttcttg taggcggggt 7380 tgggcaaagc gaaagtaaca tcattgaaga gaatcttacc ggctctgggc ataaaattgc 7440 gagtgatgcg aaaaggctgt ggtacttccg ctcgattgtt gatcacctgg gcagctagga 7500 cgatctcgtc gaaaccgttg atgttgtgtc ctacgatgta taattctatg aaacgcggcg 7560 tgcctctgac gtgaggtagc ttactgagct catcaaaggt taggtctgtg gggtcagata 7620 aggcgtagtg ttcgagagcc cattcgtgca ggtgaggatt tgcatgtagg aatgatgacc 7680 aaagatctac cgccagtgct gtttgtaact ggtcccgata ctgacgaaaa tgccggccaa 7740 ttgccatttt ttctggagtg acacagtaga aggttctggg gtcttgttgc catcgatccc 7800 acttgagttt aatggctaga tcgtgggcca tgttgacgag acgctcttct cctgagagtt 7860 tcatgaccag catgaaagga actagttgtt tgccaaagga tcccatccag gtgtaagttt 7920 ccacatcgta ggtcaggaag agtctttctg tgcgaggatg agagccgatc gggaagaact 7980 ggatttcctg ccaccagttg gaggattggc tgttgatgtg atggaagtag aagtttctgc 8040 ggcgcgccga gcattcgtgt ttgtgcttgt acagacggcc gcagtagtcg cagcgttgca 8100 cgggttgtat ctcgtgaatg agttgtacct ggcttccctt gacgagaaat ttcagtggga 8160 agccgaggcc tggcgattgt atctcgtgct cttctatatt cgctgtatcg gcctgttcat 8220 cttctgtttc gatggtggtc atgctgacga gcccccgcgg gaggcaagtc cagacctcgg 8280 cgcgggaggg gcggagctga aggacgagag cgcgcaggct ggagctgtcc agagtcctga 8340 gacgctgcgg actcaggtta gtaggtaggg acagaagatt aacttgcatg atcttttcca 8400 gggcgtgcgg gaggttcaga tggtacttga tttccacagg ttcgtttgta gagacgtcaa 8460 tggcttgcag ggttccgtgt cctttgggcg ccactaccgt acctttgttt tttcttttga 8520 tcggtggtgg ctctcttgct tcttgcatgc tcagaagcgg tgacggggac gcgcgccggg 8580 cggcagcggt tgttccggac ccgagggcat ggctggtagt ggcacgtcgg cgccgcgcac 8640 gggcaggttc tggtactgcg ctctgagaag acttgcgtgc gccaccacgc gtcgattgac 8700 gtcttgtatc tgacgtctct gggtgaaagc taccggcccc gtgagcttga acctgaaaga 8760 gagttcaaca gaatcaattt cggtatcgtt aacggcagct tgtctcagta tttcttgtac 8820 gtcaccagag ttgtcctggt aggcgatctc cgccatgaac tgctcgattt cttcctcctg 8880 aagatctccg cgacccgctc tttcgacggt ggccgcgagg tcattggaga tacggcccat 8940 gagttgggag aatgcattca tgcccgcctc gttccagacg cggctgtaaa ccacggcccc 9000 ctcggagtct cttgcgcgca tcaccacctg agcgaggtta agctccacgt gtctggtgaa 9060 gaccgcatag ttgcataggc gctgaaaaag gtagttgagt gtggtggcaa tgtgttcggc 9120 gacgaagaaa tacatgatcc atcgtctcag cggcatttcg ctaacatcgc ccagagcttc 9180 caagcgctcc atggcctcgt agaagtccac ggcaaaatta aaaaactggg agtttcgcgc 9240 ggacacggtc aattcctcct cgagaagacg gatgagttcg gctatggtgg cccgtacttc 9300 gcgttcgaag gctcccggga tctcttcttc ctcttctatc tcttcttcca ctaacatctc 9360 ttcttcgtct tcaggcgggg gcggaggggg cacgcggcga cgtcgacggc gcacgggcaa 9420 acggtcgatg aatcgttcaa tgacctctcc gcggcggcgg cgcatggttt cagtgacggc 9480 gcggccgttc tcgcgcggtc gcagagtaaa aacaccgccg cgcatctcct taaagtggtg 9540 actgggaggt tctccgtttg ggagggagag ggcgctgatt atacatttta ttaattggcc 9600 cgtagggact gcacgcagag atctgatcgt gtcaagatcc acgggatctg aaaacctttc 9660 gacgaaagcg tctaaccagt cacagtcaca aggtaggctg agtacggctt cttgtgggcg 9720 ggggtggtta tgtgttcggt ctgggtcttc tgtttcttct tcatctcggg aaggtgagac 9780 gatgctgctg gtgatgaaat taaagtaggc agttctaaga cggcggatgg tggcgaggag 9840 caccaggtct ttgggtccgg cttgctggat acgcaggcga ttggccattc cccaagcatt 9900 atcctgacat ctagcaagat ctttgtagta gtcttgcatg agccgttcta cgggcacttc 9960 ttcctcaccc gttctgccat gcatacgtgt gagtccaaat ccgcgcattg gttgtaccag 10020 tgccaagtca gctacgactc tttcggcgag gatggcttgc tgtacttggg taagggtggc 10080 ttgaaagtca tcaaaatcca caaagcggtg gtaagctcct gtattaatgg tgtaagcaca 10140 gttggccatg actgaccagt taactgtctg gtgaccaggg cgcacgagct cggtgtattt 10200 aaggcgcgaa taggcgcggg tgtcaaagat gtaatcgttg caggtgcgca ccagatactg 10260 gtaccctata agaaaatgcg gcggtggttg gcggtagaga ggccatcgtt ctgtagctgg 10320 agcgccaggg gcgaggtctt ccaacataag gcggtgatag ccgtagatgt acctggacat 10380 ccaggtgatt cctgcggcgg tagtagaagc ccgaggaaac tcgcgtacgc ggttccaaat 10440 gttgcgtagc ggcatgaagt agttcattgt aggcacggtt tgaccagtga ggcgcgcgca 10500 gtcattgatg ctctatagac acggagaaaa tgaaagcgtt cagcgactcg actccgtagc 10560 ctggaggaac gtgaacgggt tgggtcgcgg tgtaccccgg ttcgagactt gtactcgagc 10620 cggccggagc cgcggctaac gtggtattgg cactcccgtc tcgacccagc ctacaaaaat 10680 ccaggatacg gaatcgagtc gttttgctgg tttccgaatg gcagggaagt gagtcctatt 10740 tttttttttt gccgctcaga tgcatcccgt gctgcgacag atgcgccccc aacaacagcc 10800 cccctcgcag cagcagcagc agcaatcaca aaaggctgtc cctgcaacta ctgcaactgc 10860 cgccgtgagc ggtgcgggac agcccgccta tgatctggac ttggaagagg gcgaaggact 10920 ggcacgtcta ggtgcgcctt cacccgagcg gcatccgcga gttcaactga aaaaagattc 10980 tcgcgaggcg tatgtgcccc aacagaacct atttagagac agaagcggcg aggagccgga 11040 ggagatgcga gcttcccgct ttaacgcggg tcgtgagctg cgtcacggtt tggaccgaag 11100 acgagtgttg cgggacgagg atttcgaagt tgatgaaatg acagggatca gtcctgccag 11160 ggcacacgtg gctgcagcca accttgtatc ggcttacgag cagacagtaa aggaagagcg 11220 taacttccaa aagtctttta ataatcatgt gcgaaccctg attgcccgcg aagaagttac 11280 ccttggtttg atgcatttgt gggatttgat ggaagctatc attcagaacc ctactagcaa 11340 acctctgacc gcccagctgt ttctggtggt gcaacacagc agagacaatg aggctttcag 11400 agaggcgctg ctgaacatca ccgaacccga ggggagatgg ttgtatgatc ttatcaacat 11460 tctacagagt atcatagtgc aggagcggag cctgggcctg gccgagaagg tggctgccat 11520 caattactcg gttttgagct tgggaaaata ttacgctcgc aaaatctaca agactccata 11580 cgttcccata gacaaggagg tgaagataga tgggttctac atgcgcatga cgctcaaggt 11640 cttgaccctg agcgatgatc ttggggtgta tcgcaatgac agaatgcatc gcgcggttag 11700 cgccagcagg aggcgcgagt taagcgacag ggaactgatg cacagtttgc aaagagctct 11760 gactggagct ggaaccgagg gtgagaatta cttcgacatg ggagctgact tgcagtggca 11820 gcctagtcgc agggctctga gcgccgcgac ggcaggatgt gagcttcctt acatagaaga 11880 ggcggatgaa ggcgaggagg aagagggcga gtacttggaa gactgatggc acaacccgtg 11940 ttttttgcta gatggaacag caagcaccgg atcccgcaat gcgggcggcg ctgcagagcc 12000 agccgtccgg cattaactcc tcggacgatt ggacccaggc catgcaacgt atcatggcgt 12060 tgacgactcg caaccccgaa gcctttagac agcaacccca ggccaaccgt ctatcggcca 12120 tcatggaagc tgtagtgcct tcccgctcta atcccactca tgagaaggtc ctggccatcg 12180 tgaacgcgtt ggtggagaac aaagctattc gtccagatga ggccggactg gtatacaacg 12240 ctctcttaga acgcgtggct cgctacaaca gtagcaatgt gcaaaccaat ttggaccgta 12300 tgataacaga tgtacgcgaa gccgtgtctc agcgcgaaag gttccagcgt gatgccaacc 12360 tgggttcgct ggtggcgtta aatgctttct tgagtactca gcctgctaat gtgccgcgtg 12420 gtcaacagga ttatactaac tttttaagcg ctttgagact gatggtatca gaagtacctc 12480 agagcgaagt gtatcagtcc ggtcctgatt acttctttca gactagcaga cagggcttgc 12540 agacggtaaa tctgagccaa gcttttaaaa accttaaagg tttgtgggga gtgcatgccc 12600 cggtaggaga aagagcaacc gtgtctagct tgttaactcc gaactcccgc ctattattac 12660 tgttggtagc tcctttcacc gacagcggta gcatcgaccg taattcctat ttgggttacc 12720 tactaaacct gtatcgcgaa gccatagggc aaagtcaggt ggacgagcag acctatcaag 12780 aaattaccca agtcagtcgc gctttgggac aggaagacac tggcagtttg gaagccactc 12840 tgaacttctt gcttaccaat cggtctcaaa agatccctcc tcaatatgct cttactgcgg 12900 aggaggagag gatccttaga tatgtgcagc agagcgtggg attgtttctg atgcaagagg 12960 gggcaactcc gactgcagca ctggacatga cagcgcgaaa tatggagccc agcatgtatg 13020 ccagtaaccg acctttcatt aacaaactgc tggactactt gcacagagct gccgctatga 13080 actctgatta tttcaccaat gccatcttaa acccgcactg gctgccccca cctggtttct 13140 acacgggcga atatgacatg cccgacccta atgacggatt tctgtgggac gacgtggaca 13200 gcgatgtttt ttcacctctt tctgatcatc gcacgtggaa aaaggaaggc ggcgatagaa 13260 tgcattcttc tgcatcgctg tccggggtca tgggtgctac cgcggctgag cccgagtctg 13320 caagtccttt tcctagtcta cccttttctc tacacagtgt acgtagcagc gaagtgggta 13380 gaataagtcg cccgagttta atgggcgaag aggagtatct aaacgattcc ttgctcagac 13440 cggcaagaga aaaaaatttc ccaaacaatg gaatagaaag tttggtggat aaaatgagta 13500 gatggaagac ttatgctcag gatcacagag acgagcctgg gatcatgggg attacaagta 13560 gagcgagccg tagacgccag cgccatgaca gacagagggg tcttgtgtgg gacgatgagg 13620 attcggccga tgatagcagc gtgctggact tgggtgggag aggaaggggc aacccgtttg 13680 ctcatttgcg ccctcgcttg ggtggtatgt tgtaaaaaaa aataaaaaaa aaactcacca 13740 aggccatggc gacgagcgta cgttcgttct tctttattat ctgtgtctag tataatgagg 13800 cgagtcgtgc taggcggagc ggtggtgtat ccggagggtc ctcctccttc gtacgagagc 13860 gtgatgcagc agcagcaggc gacggcggtg atgcaatccc cactggaggc tccctttgtg 13920 cctccgcgat acctggcacc tacggagggc agaaacagca ttcgttattc ggaactggca 13980 cctcagtacg ataccaccag gttgtatctg gtggacaaca agtcggcgga cattgcttct 14040 ctgaactatc agaatgacca cagcaacttc ttgaccacgg tggtgcaaaa caatgacttt 14100 acccctacgg aagccagcac ccagaccatt aactttgatg aacgatcgcg gtggggcggt 14160 cagctaaaga ccatcatgca tactaacatg ccaaacgtga acgagtatat gtttagtaac 14220 aagttcaaag cgcgtgtgat ggtgtccaga aaacctcccg acggtgctgc agttggggat 14280 acttatgatc acaagcagga tattttgaaa tatgagtggt tcgagtttac tttgccagaa 14340 ggcaactttt cagttactat gactattgat ttgatgaaca atgccatcat agataattac 14400 ttgaaagtgg gtagacagaa tggagtgctt gaaagtgaca ttggtgttaa gttcgacacc 14460 aggaacttca agctgggatg ggatcccgaa accaagttga tcatgcctgg agtgtatacg 14520 tatgaagcct tccatcctga cattgtctta ctgcctggct gcggagtgga ttttaccgag 14580 agtcgtttga gcaaccttct tggtatcaga aaaaaacagc catttcaaga gggttttaag 14640 attttgtatg aagatttaga aggtggtaat attccggccc tcttggatgt agatgcctat 14700 gagaacagta agaaagaaca aaaagccaaa atagaagctg ctacagctgc tgcagaagct 14760 aaggcaaaca tagttgccag cgactctaca agggttgcta acgctggaga ggtcagagga 14820 gacaattttg cgccaacacc tgttccgact gcagaatcat tattggccga tgtgtctgaa 14880 ggaacggacg tgaaactcac tattcaacct gtagaaaaag atagtaagaa tagaagctat 14940 aatgtgttgg aagacaaaat caacacagcc tatcgcagtt ggtatctttc gtacaattat 15000 ggcgatcccg aaaaaggagt gcgttcctgg acattgctca ccacctcaga tgtcacctgc 15060 ggagcagagc aggtctactg gtcgcttcca gacatgatga aggatcctgt cactttccgc 15120 tccactagac aagtcagtaa ctaccctgtg gtgggtgcag agcttatgcc cgtcttctca 15180 aagagcttct acaacgaaca agctgtgtac tcccagcagc tccgccagtc cacctcgctt 15240 acgcacgtct tcaaccgctt tcctgagaac cagattttaa tccgtccgcc ggcgcccacc 15300 attaccaccg tcagtgaaaa cgttcctgct ctcacagatc acgggaccct gccgttgcgc 15360 agcagtatcc ggggagtcca acgtgtgacc gttactgacg ccagacgccg cacctgtccc 15420 tacgtgtaca aggcactggg catagtcgca ccgcgcgtcc tttcaagccg cactttctaa 15480 aaaaaaaaaa aatgtccatt cttatctcgc ccagtaataa caccggttgg ggtctgcgcg 15540 ctccaagcaa gatgtacgga ggcgcacgca aacgttctac ccaacatcct gtccgtgttc 15600 gcggacattt tcgcgctcca tggggcgccc tcaagggccg cactcgcgtt cgaaccaccg 15660 tcgatgatgt aatcgatcag gtggttgccg acgcccgtaa ttatactcct actgcgccta 15720 catctactgt ggatgcagtt attgacagtg tagtggctga cgctcgcaac tatgctcgac 15780 gtaagagccg gcgaaggcgc attgccagac gccaccgagc taccactgcc atgcgagccg 15840 caagagctct gctacgaaga gctagacgcg tggggcgaag agccatgctt agggcggcca 15900 gacgtgcagc ttcgggcgcc agcgccggca ggtcccgcag gcaagcagcc gctgtcgcag 15960 cggcgactat tgccgacatg gcccaatcgc gaagaggcaa tgtatactgg gtgcgtgacg 16020 ctgccaccgg tcaacgtgta cccgtgcgca cccgtccccc tcgcacttag aagatactga 16080 gcagtctccg atgttgtgtc ccagcggcga ggatgtccaa gcgcaaatac aaggaagaaa 16140 tgctgcaggt tatcgcacct gaagtctacg gccaaccgtt gaaggatgaa aaaaaacccc 16200 gcaaaatcaa gcgggttaaa aaggacaaaa aagaagagga agatggcgat gatgggctgg 16260 cggagtttgt gcgcgagttt gccccacggc gacgcgtgca atggcgtggg cgcaaagttc 16320 gacatgtgtt gagacctgga acttcggtgg tctttacacc cggcgagcgt tcaagcgcta 16380 cttttaagcg ttcctatgat gaggtgtacg gggatgatga tattcttgag caggcggctg 16440 accgattagg cgagtttgct tatggcaagc gtagtagaat aacttccaag gatgagacag 16500 tgtcgatacc cttggatcat ggaaatccca cccctagtct taaaccggtc actttgcagc 16560 aagtgttacc cgtaactccg cgaacaggtg ttaaacgcga aggtgaagat ttgtatccca 16620 ctatgcaact gatggtaccc aaacgccaga agttggagga cgttttggag aaagtaaaag 16680 tggatccaga tattcaacct gaggttaaag tgagacccat taagcaggta gcgcctggtc 16740 tgggggtaca aactgtagac attaagattc ccactgaaag tatggaagtg caaactgaac 16800 ccgcaaagcc tactgccacc tccactgaag tgcaaacgga tccatggatg cccatgccta 16860 ttacaactga cgccgccggt cccactcgaa gatcccgacg aaagtacggt ccagcaagtc 16920 tgttgatgcc caattatgtt gtacacccat ctattattcc tactcctggt taccgaggca 16980 ctcgctacta tcgcagccga aacagtacct cccgccgtcg ccgcaagaca cctgcaaatc 17040 gcagtcgtcg ccgtagacgc acaagcaaac cgactcccgg cgccctggtg cggcaagtgt 17100 accgcaatgg tagtgcggaa cctttgacac tgccgcgtgc gcgttaccat ccgagtatca 17160 tcacttaatc aatgttgccg ctgcctcctt gcagatatgg ccctcacttg tcgccttcgc 17220 gttcccatca ctggttaccg aggaagaaac tcgcgccgta gaagagggat gttgggacgc 17280 ggaatgcgac gctacaggcg acggcgtgct atccgcaagc aattgcgggg tggtttttta 17340 ccagccttaa ttccaattat cgctgctgca attggcgcga taccaggcat agcttccgtg 17400 gcggttcagg cctcgcaacg acattgacat tggaaaaaaa cgtataaata aaaaaaaaaa 17460 aatacaatgg actctgacac tcctggtcct gtgactatgt tttcttagag atggaagaca 17520 tcaatttttc atccttggct ccgcgacacg gcacgaagcc gtacatgggc acctggagcg 17580 acatcggcac gagccaactg aacgggggcg ccttcaattg gagcagtatc tggagcgggc 17640 ttaaaaattt tggctcaacc ataaaaacat acgggaacaa agcttggaac agcagtacag 17700 gacaggcgct tagaaataaa cttaaagacc agaacttcca acaaaaagta gtcgatggga 17760 tagcttccgg catcaatgga gtggtagatt tggctaacca ggctgtgcag aaaaagataa 17820 acagtcgttt ggacccgccg ccagcaaccc caggtgaaat gcaagtggag gaagaaattc 17880 ctccgccaga aaaacgaggc gacaagcgtc cgcgtcccga tttggaagag acgctggtga 17940 cgcgcgtaga tgaaccgcct tcttatgagg aagcaacgaa gcttggaatg cccaccacta 18000 gaccgatagc cccaatggcc accggggtga tgaaaccttc tcagttgcat cgacccgtca 18060 ccttggattt gccccctccc cctgctgcta ctgctgtacc cgcttctaag cctgtcgctg 18120 ccccgaaacc agtcgccgta gccaggtcac gtcccggggg cgctcctcgt ccaaatgcgc 18180 actggcaaaa tactctgaac agcatcgtgg gtctaggcgt gcaaagtgta aaacgccgtc 18240 gctgctttta attaaatatg gagtagcgct taacttgcct atctgtgtat atgtgtcatt 18300 acacgccgtc acagcagcag aggaaaaaag gaagaggagc agaggaaaaa aggaagaggt 18360 cgtgcgtcga cgctgagtta ctttcaagat ggccacccca tcgatgctgc cccaatgggc 18420 atacatgcac atcgccggac aggatgcttc ggagtacctg agtccgggtc tggtgcagtt 18480 cgcccgcgcc acagacacct acttcaatct gggaaataag tttagaaatc ccaccgtagc 18540 gccgacccac gatgtgacca ccgaccgtag ccagcggctc atgttgcgct tcgtgcccgt 18600 tgaccgggag gacaatacat actcttacaa agtgcggtac accctggccg tgggcgacaa 18660 cagagtgctg gatatggcca gcacgttctt tgacattagg ggtgtgttgg acagaggtcc 18720 cagtttcaaa ccctattctg gtacggctta caactccctg gctcctaaag gcgctccaaa 18780 tacatctcag tggattgcag aaggtgtaaa aaatacaact ggtgaggaac acgtaacaga 18840 agaggaaacc aatactacta cttacacttt tggcaatgct cctgtaaaag ctgaagctga 18900 aattacaaaa gaaggactcc cagtaggttt ggaagtttca gatgaagaaa gtaaaccgat 18960 ttatgctgat aaaacatatc agccagaacc tcagctggga gatgaaactt ggactgacct 19020 tgatggaaaa accgaaaagt atggaggcag ggctctcaaa cccgatacta agatgaaacc 19080 atgctacggg tcctttgcca aacctactaa tgtgaaaggc ggtcaggcaa aacaaaaaac 19140 aacggagcag ccaaatcaga aagtcgaata tgatatcgac atggagtttt ttgatgcggc 19200 atcgcagaaa acaaacttaa gtcctaaaat tgtcatgtat gcagaaaatg taaatttgga 19260 aactccagac actcatgtag tgtacaaacc tggaacagaa gacacaagtt ccgaagctaa 19320 tttgggacaa caatctatgc ccaacagacc caactacatt ggcttcagag ataactttat 19380 tggacttatg tactataaca gtactggtaa catgggggtg ctggctggtc aagcgtctca 19440 gttaaatgca gtggttgact tgcaggacag aaacacagaa ctttcttacc aactcttgct 19500 tgactctctg ggcgacagaa ccagatactt tagcatgtgg aatcaggctg tggacagtta 19560 tgatcctgat gtacgtgtta ttgaaaatca tggtgtggaa gatgaacttc ccaactactg 19620 ttttccactg gacggcatag gtgttccaac aaccagttac aaatcaatag ttccaaatgg 19680 agacaatgcg cctaattgga aggaacctga agtaaatgga acaagtgaga tcggacaggg 19740 taatttgttt gccatggaaa ttaaccttca agccaatcta tggcgaagtt tcctttattc 19800 caatgtggct ctatatctcc cagactcgta caaatacacc ccgtccaatg tcactcttcc 19860 agaaaacaaa aacacctacg actacatgaa cgggcgggtg gtgccgccat ctctagtaga 19920 cacctatgtg aacattggtg ccaggtggtc tctggatgcc atggacaatg tcaacccatt 19980 caaccaccac cgtaacgctg gcttgcgtta ccgatccatg cttctgggta acggacgtta 20040 tgtgcctttc cacatacaag tgcctcaaaa attcttcgct gttaaaaacc tgctgcttct 20100 cccaggctcc tacacttatg agtggaactt taggaaggat gtgaacatgg ttctacagag 20160 ttccctcggt aacgacctgc gggtagatgg cgccagcatc agtttcacga gcatcaacct 20220 ctatgctact tttttcccca tggctcacaa caccgcttcc acccttgaag ccatgctgcg 20280 gaatgacacc aatgatcagt cattcaacga ctacctatct gcagctaaca tgctctaccc 20340 cattcctgcc aatgcaacca atattcccat ttccattcct tctcgcaact gggcggcttt 20400 cagaggctgg tcatttacca gactgaaaac caaagaaact ccctctttgg ggtctggatt 20460 tgacccctac tttgtctatt ctggttctat tccctacctg gatggtacct tctacctgaa 20520 ccacactttt aagaaggttt ccatcatgtt tgactcttca gtgagctggc ctggaaatga 20580 caggttacta tctcctaacg aatttgaaat aaagcgcact gtggatggcg aaggctacaa 20640 cgtagcccaa tgcaacatga ccaaagactg gttcttggta cagatgctcg ccaactacaa 20700 catcggctat cagggcttct acattccaga aggatacaaa gatcgcatgt attcattttt 20760 cagaaacttc cagcccatga gcaggcaggt ggttgatgag gtcaattaca aagacttcaa 20820 ggccgtcgcc ataccctacc aacacaacaa ctctggcttt gtgggttaca tggctccgac 20880 catgcgccaa ggtcaaccct atcccgctaa ctatccctat ccactcattg gaacaactgc 20940 cgtaaatagt gttacgcaga aaaagttctt gtgtgacaga accatgtggc gcataccgtt 21000 ctcgagcaac ttcatgtcta tgggggccct tacagacttg ggacagaata tgctctatgc 21060 caactcagct catgctctgg acatgacctt tgaggtggat cccatggatg agcccaccct 21120 gctttatctt ctcttcgaag ttttcgacgt ggtcagagtg catcagccac accgcggcat 21180 catcgaggca gtctacctgc gtacaccgtt ctcggccggt aacgctacca cgtaagaagc 21240 ttcttgcttc ttgcaaatag cagctgcaac catggcctgc ggatcccaaa acggctccag 21300 cgagcaagag ctcagagcca ttgtccaaga cctgggttgc ggaccctatt ttttgggaac 21360 ctacgataag cgcttcccgg ggttcatggc ccccgataag ctcgcctgtg ccattgtaaa 21420 tacggccgga cgtgagacgg ggggagagca ctggttggct ttcggttgga acccacgttc 21480 taacacctgc tacctttttg atccttttgg attctcggat gatcgtctca aacagattta 21540 ccagtttgaa tatgagggtc tcctgcgccg cagcgctctt gctaccaagg accgctgtat 21600 tacgctggaa aaatctaccc agaccgtgca gggtccccgt tctgccgcct gcggactttt 21660 ctgctgcatg ttccttcacg cctttgtgca ctggcctgac cgtcccatgg acggaaaccc 21720 caccatgaaa ttgctaactg gagtgccaaa caacatgctt cattctccta aagtccagcc 21780 caccctgtgt gacaatcaaa aagcactcta ccattttctt aatacccatt cgccttattt 21840 tcgctcccat cgtacacaca tcgaaagggc cactgcgttc gaccgtatgg atgttcaata 21900 atgactcatg taaacaacgt gttcaataaa catcacttta tttttttaca tgtatcaagg 21960 ctctgcatta cttatttatt tacaagtcga atgggttctg acgagaatca gaatgacccg 22020 caggcagtga tacgttgcgg aactgatact tgggttgcca cttgaattcg ggaatcacca 22080 acttgggaac cggtatatcg ggcaggatgt cactccacag ctttctggtc agctgcaaag 22140 ctccaagcag gtcaggagcc gaaatcttga aatcacaatt aggaccagtg ctttgagcgc 22200 gagagttgcg gtacaccgga ttgcagcact gaaacaccat cagcgacgga tgtctcacgc 22260 ttgccagcac ggtgggatct gcaatcatgc ccacatccag atcttcagca ttggcaatgc 22320 tgaacggggt catcttgcag gtctgcctac ccatggcggg cacccaatta ggcttgtggt 22380 tgcaatcgca gtgcaggggg atcagtatca tcttggcctg atcctgtctg attcctggat 22440 acacggctct catgaaagca tcatattgct tgaaagcctg ctgggcttta ctaccctcgg 22500 tataaaacat cccgcaggac ctgctcgaaa actggttagc tgcacagccg gcatcattca 22560 cacagcagcg ggcgtcattg ttagctattt gcaccacact tctgccccag cggttttggg 22620 tgattttggt tcgctcggga ttctccttta aggctcgttg tccgttctcg ctggccacat 22680 ccatctcgat aatctgctcc ttctgaatca taatattgcc atgcaggcac ttcagcttgc 22740 cctcataatc attgcagcca tgaggccaca acgcacagcc tgtacattcc caattatggt 22800 gggcgatctg agaaaaagaa tgtatcattc cctgcagaaa tcttcccatc atcgtgctca 22860 gtgtcttgtg actagtgaaa gttaactgga tgcctcggtg ctcctcgttt acgtactggt 22920 gacagatgcg cttgtattgt tcgtgttgct caggcattag tttaaaagag gttctaagtt 22980 cgttatccag cctgtacttc tccatcagca gacacatcac ttccatgcct ttctcccaag 23040 cagacaccag gggcaagcta atcggattct taacagtgca ggcagcagct cctttagcca 23100 gagggtcatc tttagcgatc ttctcaatgc ttcttttgcc atccttctca acgatgcgca 23160 cgggcgggta gctgaaaccc actgctacaa gttgcgcctc ttctctttct tcttcgctgt 23220 cttgactgat gtcttgcatg gggatatgtt tggtcttcct tggcttcttt ttggggggta 23280 tcggaggagg aggactgtcg ctccgttccg gagacaggga ggattgtgac gtttcgctca 23340 ccattaccaa ctgactgtcg gtagaagaac ctgaccccac acggcgacag gtgtttctct 23400 tcgggggcag aggtggaggc gattgcgaag ggctgcggtc cgacctggaa ggcggatgac 23460 tggcagaacc ccttccgcgt tcgggggtgt gctccctgtg gcggtcgctt aactgatttc 23520 cttcgcggct ggccattgtg ttctcctagg cagagaaaca acagacatgg aaactcagcc 23580 attgctgtca acatcgccac gagtgccatc acatctcgtc ctcagcgacg aggaaaagga 23640 gcagagctta agcattccac cgcccagtcc tgccaccacc tctaccctag aagataagga 23700 ggtcgacgca tctcatgaca tgcagaataa aaaagcgaaa gagtctgaga cagacatcga 23760 gcaagacccg ggctatgtga caccggtgga acacgaggaa gagttgaaac gctttctaga 23820 gagagaggat gaaaactgcc caaaacaacg agcagataac tatcaccaag atgctggaaa 23880 tagggatcag aacaccgact acctcatagg gcttgacggg gaagacgcgc tccttaaaca 23940 tctagcaaga cagtcgctca tagtcaagga tgcattattg gacagaactg aagtgcccat 24000 cagtgtggaa gagctcagcc gcgcctacga gcttaacctc ttttcacctc gtactccccc 24060 caaacgtcag ccaaacggca cctgcgagcc aaatcctcgc ttaaactttt atccagcttt 24120 tgctgtgcca gaagtactgg ctacctatca catctttttt aaaaatcaaa aaattccagt 24180 ctcctgccgc gctaatcgca cccgcgccga tgccctactc aatctgggac ctggttcacg 24240 cttacctgat atagcttcct tggaagaggt tccaaagatc ttcgagggtc tgggcaataa 24300 tgagactcgg gccgcaaatg ctctgcaaaa gggagaaaat ggcatggatg agcatcacag 24360 cgttctggtg gaattggaag gcgataatgc cagactcgca gtactcaagc gaagcatcga 24420 ggtcacacac ttcgcatatc ccgctgtcaa cctgccccct aaagtcatga cggcggtcat 24480 ggaccagtta ctcattaagc gcgcaagtcc cctttcagaa gacatgcatg acccagatgc 24540 ctgtgatgag ggtaaaccag tggtcagtga tgagcagcta acccgatggc tgggcaccga 24600 ctctcccagg gatttggaag agcgtcgcaa gcttatgatg gccgtggtgc tggttaccgt 24660 agaactagag tgtctccgac gtttctttac cgattcagaa accttgcgca aactcgaaga 24720 gaatctgcac tacactttta gacacggctt tgtgcggcag gcatgcaaga tatctaacgt 24780 ggaactcacc aacctggttt cctacatggg tattctgcat gagaatcgcc taggacaaag 24840 cgtgctgcac agcaccctga agggggaagc ccgccgtgat tacatccgcg attgtgtcta 24900 tctgtacctg tgccacacgt ggcaaaccgg catgggtgta tggcagcaat gtttagaaga 24960 acagaacttg aaagagcttg acaagctctt acagaaatct cttaaggttc tgtggacagg 25020 gttcgacgag cgcaccgtcg cttccgacct ggcagacctc atcttcccag agcgtctcag 25080 ggttactttg cgaaacggat tgcctgactt tatgagccag agcatgctta acaattttcg 25140 ctctttcatc ctggaacgct ccggtatcct gcccgccacc tgctgcgcac tgccctccga 25200 ctttgtgcct ctcacctacc gcgagtgccc cccgccgcta tggagtcact gctacctgtt 25260 ccgtctggcc aactatctct cctaccactc ggatgtgatc gaggatgtga gcggagacgg 25320 cttgctggag tgtcactgcc gctgcaatct gtgcacgccc caccggtccc tagcttgcaa 25380 cccccagttg atgagcgaaa cccagataat aggcaccttt gaattgcaag gccccagcag 25440 ccaaggcgat gggtcttctc ctgggcaaag tttaaaactg accccgggac tgtggacctc 25500 cgcctacttg cgcaagtttg ctccggaaga ttaccacccc tatgaaatca agttctatga 25560 ggaccaatca cagcctccaa aggccgaact ttcggcctgc gtcatcaccc agggggcaat 25620 tctggcccaa ttgcaagcca tccaaaaatc ccgccaagaa tttctactga aaaagggtaa 25680 gggggtctac cttgaccccc agaccggcga ggaactcaac acaaggttcc ctcaggatgt 25740 cccaacgacg agaaaacaag aagttgaagg tgcagccgcc gcccccagaa gatatggagg 25800 aagattggga cagtcaggca gaggaggcgg aggaggacag tctggaggac agtctggagg 25860 aagacagttt ggaggaggaa aacgaggagg cagaggaggt ggaagaagta accgccgaca 25920 aacagttatc ctcggctgcg gagacaagca acagcgctac catctccgct ccgagtcgag 25980 gaacccggcg gcgtcccagc agtagatggg acgagaccgg acgcttcccg aacccaacca 26040 gcgcttccaa gaccggtaag aaggatcggc agggatacaa gtcctggcgg gggcataaga 26100 atgccatcat ctcctgcttg catgagtgcg ggggcaacat atccttcacg cggcgctact 26160 tgctattcca ccatggggtg aactttccgc gcaatgtttt gcattactac cgtcacctcc 26220 acagccccta ctatagccag caaatcccgg cagtctcgac agataaagac agcggcggcg 26280 acctccaaca gaaaaccagc agcggcagtt agaaaataca caacaagtgc agcaacagga 26340 ggattaaaga ttacagccaa cgagccagcg caaacccgag agttaagaaa tcggatcttt 26400 ccaaccctgt atgccatctt ccagcagagt cggggtcaag agcaggaact gaaaataaaa 26460 aaccgatctc tgcgttcgct caccagaagt tgtttgtatc acaagagcga agatcaactt 26520 cagcgcactc tcgaggacgc cgaggctctc ttcaacaagt actgcgcgct gactcttaaa 26580 gagtaggcag cgaccgcgct tattcaaaaa aggcgggaat tacatcatcc tcgacatgag 26640 taaagaaatt cccacgcctt acatgtggag ttatcaaccc caaatgggat tggcggcagg 26700 cgcctcccag gactactcca cccgcatgaa ttggctcagc gccgggcctt ctatgatttc 26760 tcgagttaat gatatacgcg cctaccgaaa ccaaatactt ttggaacagt cagctcttac 26820 caccacgccc cgccaacacc ttaatcccag aaattggccc gccgccctag tgtaccagga 26880 aagtcccgct cccaccactg tattacttcc tcgagacgcc caggccgaag tccaaatgac 26940 taatgcaggt gcgcagttag ctggcggctc caccctatgt cgtcacaggc ctcggcataa 27000 tataaaacgc ctgatgatca gaggccgagg tatccagctc aacgacgagt cggtgagctc 27060 tccgcttggt ctacgaccag acggaatctt tcagattgcc ggctgcggga gatcttcctt 27120 cacccctcgt caggctgttc tgactttgga aagttcgtct tcgcaacccc gctcgggcgg 27180 aatcgggacc gttcaatttg tggaggagtt tactccctct gtctacttca accccttctc 27240 cggatctcct gggcattacc cggacgagtt cataccgaac ttcgacgcga ttagcgagtc 27300 agtggacggc tacgattgag gatgttaagt ggagaggcag agcaactgcg cctgaaacac 27360 ctggtccact gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt 27420 gaattgcccg aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga 27480 gagcttgccc gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac 27540 aggggaccct gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat 27600 ctttgttgcc atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc 27660 ctatcgccat cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt 27720 acctggtact tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt 27780 gagtctacga gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct 27840 tacctgccgg gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg 27900 taaaccagac tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc 27960 ttagaaaacc cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt 28020 caagcaactc tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc 28080 tctgtcttgt gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct 28140 gctgtgtgca catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat 28200 gattaggtac ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa 28260 ggtggatttt aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac 28320 cactcttata aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat 28380 tggcaagtat gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac 28440 agttttccag ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg 28500 cgacattacc atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga 28560 aaacactggc actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac 28620 cctactctat attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta 28680 atttactaag ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca 28740 aattcaaaaa gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct 28800 caataccatt cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg 28860 aagtcaggct tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt 28920 tccagtccaa ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc 28980 cgctaccgga cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg 29040 ggataacttg ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat 29100 gtggctcatc tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat 29160 tgtgctacac ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt 29220 ttctcttaca gtatgattaa atgagacatg attcctcgag tttttatatt actgaccctt 29280 gttgcgcttt tttgtgcgtg ctccacattg gctgcggttt ctcacatcga agtagactgc 29340 attccagcct tcacagtcta tttgctttac ggatttgtca ccctcacgct catctgcagc 29400 ctcatcactg tggtcatcgc ctttatccag tgcattgact gggtctgtgt gcgctttgca 29460 tatctcagac accatcccca gtacagggac aggactatag ctgagcttct tagaattctt 29520 taattatgaa atttactgtg acttttctgc tgattatttg caccctatct gcgttttgtt 29580 ccccgacctc caagcctcaa agacatatat catgcagatt cactcgtata tggaatattc 29640 caagttgcta caatgaaaaa agcgatcttt ccgaagcctg gttatatgca atcatctctg 29700 ttatggtgtt ctgcagtacc atcttagccc tagctatata tccctacctt gacattggct 29760 ggaacgcaat agatgccatg aaccacccaa ctttccccgc gcccgctatg cttccactgc 29820 aacaagttgt tgccggcggc tttgtcccag ccaatcagcc tcgcccacct tctcccaccc 29880 ccactgaaat cagctacttt aatctaacag gaggagatga ctgacaccct agatctagaa 29940 atggacggaa ttattacaga gcagcgcctg ctagaaagac gcagggcagc ggccgagcaa 30000 cagcgcatga atcaagagct ccaagacatg gttaacttgc accagtgcaa aaggggtatc 30060 ttttgtctgg taaagcaggc caaagtcacc tacgacagta ataccaccgg acaccgcctt 30120 agctacaagt tgccaaccaa gcgtcagaaa ttggtggtca tggtgggaga aaagcccatt 30180 accataactc agcactcggt agaaaccgaa ggctgcattc actcaccttg tcaaggacct 30240 gaggatctct gcacccttat taagaccctg tgcggtctca aagatcttat tccctttaac 30300 taataaaaaa aaataataaa gcttaatcac ttacttgaaa tcagcaataa ggtctctgtt 30360 gaaattttct cccagcagca cctcacttcc ctcttcccaa ctctggtatt ctaaaccccg 30420 ttcagcggca tactttctcc atactttaaa ggggatgtca aattttagct cctctcctgt 30480 acccacaatc ttcatgtctt tcttcccaga tgaccaagag agtccggctc agtgactcct 30540 tcaaccctgt ctacccctat gaagatgaaa gcacctccca acaccccttt ataaacccag 30600 ggtttatttc cccaaatggc ttcacacaaa gcccaaacgg agttcttact ttaaaatgtt 30660 taaccccact aacaaccaca ggcggatctc tacagctaaa agtgggaggg ggacttacag 30720 tggatgacac caacggtttt ttgaaagaaa acataagtgc caccacacca ctcgttaaga 30780 ctggtcactc tataggttta ccactaggag ccggattggg aacgaatgaa aataaacttt 30840 gtatcaaatt aggacaagga cttacattca attcaaacaa catttgcatt gatgacaata 30900 ttaacacctt atggacagga gtcaacccca ccgaagccaa ctgtcaaatc atgaactcca 30960 gtgaatctaa tgattgcaaa ttaattctaa cactagttaa aactggagca ctagtcactg 31020 catttgttta tgttatagga gtatctaaca attttaatat gctaactaca cacagaaata 31080 taaattttac tgcagagctg tttttcgatt ctactggtaa tttactaact agactctcat 31140 ccctcaaaac tccacttaat cataaatcag gacaaaacat ggctactggt gccattacta 31200 atgctaaagg tttcatgccc agcacgactg cctatccttt caatgataat tctagagaaa 31260 aagaaaacta catttacgga acttgttact acacagctag tgatcgcact gcttttccca 31320 ttgacatatc tgtcatgctt aaccgaagag caataaatga cgagacatca tattgtattc 31380 gtataacttg gtcctggaac acaggagatg ccccagaggt gcaaacctct gctacaaccc 31440 tagtcacctc cccatttacc ttttactaca tcagagaaga cgactaataa agaatcgttt 31500 gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcgaatca tttttcattc 31560 agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa tcaaacctac 31620 atgggggtag agtcataatc gtgcatcagg atagggcggt ggtgctgcag cagcgcgcga 31680 ataaactgct gccgccgccg ctccgtcctg caggaataca acatggcagt ggtctcctca 31740 gcgatgattc gcaccgcccg cagcataagg cgccttgtcc tccgggcaca gcagcgcacc 31800 ctgatctcac ttaaatcagc acagtaactg cagcacagca ccacaatatt gttcaaaatc 31860 ccacagtgca aggcgctgta tccaaagctc atggcgggga ccacagaacc cacgtggcca 31920 tcataccaca agcgcaggta gattaagtgg cgacccctca taaacacgct ggacataaac 31980 attacctctt ttggcatgtt gtaattcacc acctcccggt accatataaa cctctgatta 32040 aacatggcgc catccaccac catcctaaac cagctggcca aaacctgccc gccggctata 32100 cactgcaggg aaccgggact ggaacaatga cagtggagag cccaggactc gtaaccatgg 32160 atcatcatgc tcgtcatgat atcaatgttg gcacaacaca ggcacacgtg catacacttc 32220 ctcaggatta caagctcctc ccgcgttaga accatatccc agggaacaac ccattcctga 32280 atcagcgtaa atcccacact gcagggaaga cctcgcacgt aactcacgtt gtgcattgtc 32340 aaagtgttac attcgggcag cagcggatga tcctccagta tggtagcgcg ggtttctgtc 32400 tcaaaaggag gtagacgatc cctactgtac ggagtgcgcc gagacaaccg agatcgtgtt 32460 ggtcgtagtg tcatgccaaa tggaacgccg gacgtagtca tatttcctga agcaaaacca 32520 ggtgcgggcg tgacaaacag atctgcgtct ccggtctcgc cgcttagatc gctctgtgta 32580 gtagttgtag tatatccact ctctcaaagc atccaggcgc cccctggctt cgggttctat 32640 gtaaactcct tcatgcgccg ctgccctgat aacatccacc accgcagaat aagccacacc 32700 cagccaacct acacattcgt tctgcgagtc acacacggga ggagcgggaa gagctggaag 32760 aaccatgttt ttttttttat tccaaaagat tatccaaaac ctcaaaatga agatctatta 32820 agtgaacgcg ctcccctccg gtggcgtggt caaactctac agccaaagaa cagataatgg 32880 catttgtaag atgttgcaca atggcttcca aaaggcaaac ggccctcacg tccaagtgga 32940 cgtaaaggct aaacccttca gggtgaatct cctctataaa cattccagca ccttcaacca 33000 tgcccaaata attctcatct cgccaccttc tcaatatatc tctaagcaaa tcccgaatat 33060 taagtccggc cattgtaaaa atctgctcca gagcgccctc caccttcagc ctcaagcagc 33120 gaatcatgat tgcaaaaatt caggttcctc acagacctgt ataagattca aaagcggaac 33180 attaacaaaa ataccgcgat cccgtaggtc ccttcgcagg gccagctgaa cataatcgtg 33240 caggtctgca cggaccagcg cggccacttc cccgccagga accatgacaa aagaacccac 33300 actgattatg acacgcatac tcggagctat gctaaccagc gtagccccga tgtaagcttg 33360 ttgcatgggc ggcgatataa aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg 33420 caaaaaagaa agcacatcgt agtcatgctc atgcagataa aggcaggtaa gctccggaac 33480 caccacagaa aaagacacca tttttctctc aaacatgtct gcgggtttct gcataaacac 33540 aaaataaaat aacaaaaaaa catttaaaca ttagaagcct gtcttacaac aggaaaaaca 33600 acccttataa gcataagacg gactacggcc atgccggcgt gaccgtaaaa aaactggtca 33660 ccgtgattaa aaagcaccac cgacagctcc tcggtcatgt ccggagtcat aatgtaagac 33720 tcggtaaaca catcaggttg attcacatcg gtcagtgcta aaaagcgacc gaaatagccc 33780 gggggaatac atacccgcag gcgtagagac aacattacag cccccatagg aggtataaca 33840 aaattaatag gagagaaaaa cacataaaca cctgaaaaac cctcctgcct aggcaaaata 33900 gcaccctccc gctccagaac aacatacagc gcttccacag cggcagccat aacagtcagc 33960 cttaccagta aaaaagaaaa cctattaaaa aaacaccact cgacacggca ccagctcaat 34020 cagtcacagt gtaaaaaagg gccaagtgca gagcgagtat atataggact aaaaaatgac 34080 gtaacggtta aagtccacaa aaaacaccca gaaaaccgca cgcgaaccta cgcccagaaa 34140 cgaaagccaa aaaacccaca acttcctcaa atcgtcactt ccgttttccc acgttacgtc 34200 acttcccatt ttaagaaaac tacaattccc aacacataca agttactccg ccctaaaacc 34260 tacgtcaccc gccccgttcc cacgccccgc gccacgtcac aaactccacc ccctcattat 34320 catattggct tcaatccaaa ataaggtata ttattgatga tg 34362 <210> 94 <211> 33510 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO167X) <400> 94 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccttaatga 3600 acgggaccgg cggggccttc gaaggggggc tttttagccc ttatttgaca acccgcctgc 3660 cgggatgggc cggagttcgt cagaatgtga tgggatcgac ggtggatggg cgcccagtgc 3720 ttccagcaaa ttcctcgacc atgacctacg cgaccgtggg gagctcgtcg ctcgacagca 3780 ccgccgcagc cgcggcagcc gcagctgcca tgacagcgac gagactggcc tcgagctaca 3840 tgcccagcag cggcagcagc ccctctgtgc ccagttccat catcgccgag gagaaactgc 3900 tggccctgct ggccgagctg gaagccctga gccgccagct ggccgccctg acccagcagg 3960 tgtccgagct ccgcgagcag caacagcagc aaaataaata aaacataaat aaaaaaccag 4020 actctgtttg gatttggatc aagcaagtaa acacagattc tgattcaaac agcaaagcat 4080 ctttattatt tattttttcg cgcgcggtag gccctggtcc acctctcccg atcattgaga 4140 gtgcggtgga ttttttccag gacccggtag aggtgggatt ggatgttgag gtacatgggc 4200 atgagcccgt cccgggggtg gaggtagcac cactgcatgg cctcgtgctc tggggtcgtg 4260 ttgtagatga tccagtcata gcaggggcgc tgggcgtggt gctggatgat gtctttgaga 4320 aggagactga tggccacggg gagccccttg gtgtaggtat tggcgaagcg gttgagctgg 4380 gagggatgca tgcgggggga gatgatgtgc agtttggcct ggatcttgag gttggcgatg 4440 ttgccaccca gatcccgccg ggggttcatg ttgtgcagga ccaccaggac ggtgtagccc 4500 gtgcacttgg ggaacttgtc atgcaacttg gaagggaatg cgtggaagaa tttggagacg 4560 cccttgtgcc cgcccaggtt ttccatgcat tcatccatga tgatggcgat gggcccgtgg 4620 gctgcggctt tggcaaagac gtttctgggg tcagatacat cataattatg ctcctgggtg 4680 agatcatcat aagacatttt aatgaatttg gggcggaggg tgccagattg ggggacgatg 4740 gttccctcgg gccccggggc gaagttcccc tcacagatct gcatctccca ggctttcatc 4800 tcggaggggg ggatcatgtc cacctgcggg gcgatgaaaa aaacggtttc cggggctggg 4860 gtgatgagct gcgaagagag caggtttctc aacagctggg acttgccgca cccggtcggg 4920 ccgtagatga ccccgatgac gggttgcagg tggtagttca aggacatgca gctgccgtcg 4980 tcccggagga ggggggccac ctcgttgagc atgtctctga cttggaggtt ttcccgaacg 5040 agctcgccga ggaggcggtc cccgcccagc gagaggagct cttgcaggga agcaaagttt 5100 ttcaggggct tgagtccgtc ggccatgggc atcttggcga gggtctgcga gaggagctcc 5160 aggcggtccc agagctcggt gacgtgctct acggcatctc gatccagcag acttcctcgt 5220 ttcgggggtt gggacgactg cgactgtagg gcacgagacg atgggcgtcc agcgcggcca 5280 gcgtcatgtc cttccagggt ctcagggtcc gagtgagggt ggtctccgtc acggtgaagg 5340 ggtgggcccc tggctgggcg cttgcaaggg tgcgcttgag actcatcctg ctggtgctga 5400 aacgggcacg gtcttcgccc tgcgagtcgg cgagatagca gttgaccatg agctcgtagt 5460 tgagggcctc ggcggcgtgg cccttggcgc ggagcttgcc cttggaagag cgcccgcagg 5520 cgggacagag gagggattgc agggcgtaga gcttgggggc gagaaagacg gactcgggag 5580 cgaaagcgtc cgctccgcag tgggcgcaga cggtctcgca ctcgacgagc caggtgagct 5640 ctggctgctc ggggtcaaaa accagttttc ccccgttctt tttgatgcgc ttcttacctc 5700 gcgtctccat gagtctgtgt ccgcgctcgg tgacaaacag gctgtcggtg tccccgtaga 5760 cggacttgat tggcctgtcc tgcaggggcg tcccgcggtc ctcctcgtag agaaactcgg 5820 accactctga gacaaaggcg cgcgtccacg ccaagacaaa ggaggccacg tgcgaggggt 5880 agcggtcgtt gtccactagg gggtccacct tttccaccgt gtgcagacac atgtccccct 5940 cctccgcatc caagaaggtg attggcttgt aggtgtaggc cacgtgaccg ggggtccccg 6000 acgggggggt ataaaagggg gcgggtctgt gctcgtcctc actctcttcc gcgtcgctgt 6060 ccacgagcgc cagctgttgg ggtaggtatt ccctctcgag agcgggcatg acctcggcac 6120 tcaggttgtc agtttctaga aacgaggagg atttgatgtt ggcttgccct gccgcgatgc 6180 tttttaggag actttcatcc atctggtcag aaaagactat ttttttattg tcaagcttgg 6240 tggcgaagga gccatagagg gcgttggata gaagcttggc gatggatctc atggtctgat 6300 ttttgtcacg gtcggcgcgc tccttggccg cgatgtttag ctggacatac tcgcgcgcga 6360 cgcacttcca ttcggggaag acggtggtgc gctcgtcggg cacgatcctg acgcgccagc 6420 cgcggttatg cagggtgacc aggtccacgc tggtggccac ctcgccgcgc aggggctcgt 6480 tggtccagca gagtctgccg cccttgcgcg agcagaacgg gggcagcaca tcaagcagat 6540 gctcgtcagg ggggtccgca tcgatggtga agatgcccgg acagagttcc ttgtcaaaat 6600 aatcgatttt tgaggatgca tcatccaagg ccatctgcca ctcgcgggcg gccagcgctc 6660 gctcgtaggg gttgaggggc ggaccccagg gcatgggatg agtgagggcg gaggcgtaca 6720 tgccgcagat gtcgtagaca tagatgggct ccgagaggat gccgatgtag gtgggataac 6780 agcgcccccc gcggatgctg gcgcgcacgt agtcatacaa ctcgtgcgag ggggccaaga 6840 aggcggggcc gagattggtg cgctggggct gctcggcgcg gaagacgatc tggcgaaaga 6900 tggcgtgcga gttggaggag atggtgggcc gttggaagat gttaaagtgg gcgtggggca 6960 agcggaccga gtcgcggatg aagtgcgcgt aggagtcttg cagcttggcg acgagctcgg 7020 cggtgacgag gacgtccatg gcgcagtagt ccagcgtttc gcggatgatg tcataacccg 7080 cctctccttt cttctcccac agctcgcggt tgagggcgta ctcctcgtca tccttccagt 7140 actcccggag cgggaatcct cgatcgtccg cacggtaaga gcccagcatg tagaaatggt 7200 tcacggcctt gtagggacag cagcccttct ccacggggag ggcgtaagct tgagcggcct 7260 tgcggagcga ggtgtgcgtc agggcgaagg tgtccctgac catgactttc aagaactggt 7320 acttgaaatc cgagtcgtcg cagccgccgt gctcccagag ctcgaaatcg gtgcgcttct 7380 tcgagagggg gttaggcaga gcgaaagtga cgtcattgaa gagaatcttg cctgctcgcg 7440 gcatgaaatt gcgggtgatg cggaaagggc ccgggacgga ggctcggttg ttgatcacct 7500 gggcggcaag gacgatctcg tcgaagccgt tgatgttgtg cccgacgatg tagagttcca 7560 tgaatcgcgg gcggcctttg atgtgcggca gctttttgag ctcctcgtag gtgaggtcct 7620 cggggcattg caggccgtgc tgctctagcg cccactcctg gagatgtggg ttggcttgca 7680 tgaaggaagc ccagagctcg cgggccatga gggtctggag ctcgtcgcga aagaggcgga 7740 actgctggcc cacggccatc ttttctgggg tgacgcagta gaaggtgagg gggtcccgct 7800 cccagcgatc ccagcgtaag cgcacggcga gatcgcgagc gagggcgacc agctcgggtt 7860 cccccgagaa tttcatgacc agcatgaagg ggacgagctg cttgccgaag gaccccatcc 7920 aggtgtaggt ttctacatcg taggtgacaa agagccgctc cgtgcgagga tgagagccga 7980 ttgggaagaa ctggatttcc tgccaccagt tggacgagtg gctgttgatg tgatgaaagt 8040 agaaatcccg ccggcgaacc gagcactcgt gctgatgctt gtaaaagcgt ccgcagtact 8100 cgcagcgctg cacgggctgt acctcatcca cgagatacac agcgcgtccc ttgaggagga 8160 acttcaggag tggcggccct ggctggtggc tttcatgttc gcctgcgtgg gactcaccct 8220 ggggctcctc gaggacggag aggctgacga gcccgcgcgg gagccaggtc cagatctcgg 8280 cgcggcgggg gcggagagcg aagacgaggg cgcgcagttg ggagctgtcc atggtgtcgc 8340 ggagatccag gtccgggggc agggttctga ggttgacctc gtagaggcgg gtgagggcgt 8400 gcttgagatg cagatggtac ttgatctcca cgggtgagtt ggtggtcgtg tccacgcatt 8460 gcatgagccc gtagctgcgc ggggccacga ccgtgccgcg gtgcgctttt agaagcggtg 8520 tcgcgggcgt gctcccggcg gcagcggcgg ttctggcccc gcgggcaggg gcggcagagg 8580 cacgtcggcg tggcgctcgg gcaggtcccg gtgctgcgcc ctgagagcgc tggcgtgcgc 8640 gacgacgcgg cggttgacat cctggatctg ccgcctctgc gtgaagacca cgggccccgt 8700 gactttgaac ctgaaagaca gttcaacaga atcaatctct gcgtcattga cggcggcctg 8760 acgcaggatc tcttgcacgt cgcccgagtt gtcctggtag gcgatctcgg tcatgaactg 8820 ttcgatctcc tcctcctgga gatcgccgcg gcccgcgcgc tccacggtgg cggcgaggtc 8880 attggagatg cggcccatga gctgcgagaa ggcgcccagg ccgctctcgt tccagacgcg 8940 gctgtagacc acgtccccgt cggcgtcgcg tgcgcgcatg accacctgcg cgaggttgag 9000 ctccacgtgc cgcgtgaaga cggcgtagtt gcgcaggcgc tggaagaggt agttgagggt 9060 ggtggcgatg tgctcggtga cgaagaagta catgatccag cggcgcaggg gcatctcgct 9120 gatgtcgccg atggcctcca gcctttccat ggcctcgtag aaatccacgg cgaagttgaa 9180 aaactgggca ttgcgggccg agaccgtgag ctcgtcttcc aggagccgga tgagctcggc 9240 gatggtggcg cgcacctcgc gctcgaaatc cccgggggcc tcctcttctt cctcttcttc 9300 catgacgacc tcttcttcta tttcttcctc tgggggcggt ggtggtggcg gggcccgacg 9360 acgacggcga cgcaccggga gacggtcgac gaagcgctcg atcatctccc cgcggcggcg 9420 acgcatggtt tcggtgacgg cgcgaccccg ttcgcgagga cgcagcgtga agacgccgcc 9480 ggtcatctcc cggtaatggg gcgggtcccc gttgggcagc gatagggcgc tgacgatgca 9540 tcttatcaat tgcggtgtag gggacgtgag cgcgtcgaga tcgaccggat cggagaatct 9600 ttcgaggaaa gcgtctagcc aatcgcagtc gcaaggtaag ctcaaacacg tagcagccct 9660 gtggacgctg ttagaattgc ggttgctgat gatgtaattg aagtaggcgt ttttgaggcg 9720 gcggatggtg gcgaggagga ccaggtcctt gggtcccgct tgctggatgc ggagccgctc 9780 ggccatgccc caggcctggc cctgacaccg gctcaggttc ttgtagtagt catgcatgag 9840 cctctcgatg tcatcactgg cggaggcgga gtcttccatg cgggtgaccc cgacgcccct 9900 gagcggctgc acgagcgcca ggtcggcgac gacgcgctcg gcgaggatgg cctgttgcac 9960 gcgggtgagg gtgtcctgga agtcgtccat gtcgacaaag cggtggtagg ccccggtgtt 10020 gatggtgtag gtgcagttgg ccatgagcga ccagttgacg gtctgcaggc cgggttgcac 10080 gacctcggag tacctgagcc gcgagaaggc gcgcgagtcg aagacgtagt cattgcaggt 10140 gcgcacgagg tactggtagc cgactaggaa gtgcggcggc ggctggcggt agagcggcca 10200 gcgctgggtg gccggcgcgc ccggggccag gtcctcgagc atgaggcggt ggtagccgta 10260 gaggtagcgg gacatccagg tgatgccggc ggcggtggtg gaggcgcgcg ggaactcgcg 10320 gacgcggttc cagatgttgc gcagcggcag gaaatagtcc atggtcggca cggtctggcc 10380 ggtgagacgc gcgcagtcat tgacgctcta gaggcaaaaa cgaaagcggt tgagcgggct 10440 cttcctccgt agcctggcgg aacgcaaacg ggttaggccg cgtgtgtacc ccggttcgag 10500 tccccttgaa tcaggctgga gccgcgacta acgtggtatt ggcactcccg tctcgacccg 10560 agcccgatag ccgccaggat acggcggaga gtcctttttg ccggccaagg ggggtcgcta 10620 gacttgaaag cgaccgaaaa ccctgccggg tagtggctcg cgcccgtagt ctggagaagc 10680 atcgccaggg ttgagtcgcg gcagaacccg gttcgcggac ggccgcggcg agcgggactt 10740 ggtcaccccg ccgatttaaa gacccacagc cagccgactt ctccagttac gggagcgagc 10800 cccctttttt ctttttgcca gatgcatccc gtcctgcgcc aaatgcgtcc cacccccccg 10860 gcgaccaccg cgaccgcggc cgtagcaggc gccggcgcta gccagccaca gccacagaca 10920 gagatggact tggaagaggg cgaagggctg gcgagactgg gggcgccgtc cccggagcga 10980 cacccccgcg tgcagctgca gaaggacgtg cgcccggcgt acgtgcctgc gcagaacctg 11040 ttcagggacc gcagcgggga ggagcccgag gagatgcgcg actgccggtt tcgggcgggc 11100 agggagctgc gcgagggcct ggaccgccag cgcgtgctgc gcgacgagga tttcgagccg 11160 aacgagcaga cggggatcag ccccgcgcgc gctcacgtgg cggcggccaa cctggtgacg 11220 gcctacgagc agacggtgaa gcaggagcgc aacttccaaa agagtttcaa caaccacgtg 11280 cgcaccctga tcgcgcgcga ggaggtggcc ctgggcctga tgcacctgtg ggacctggcg 11340 gaggccatcg tgcagaaccc ggacagcaag cctctgacgg cgcagctgtt cctggtggtg 11400 cagcacagca gggacaacga ggcgttcagg gaggcactgc tgaacatcgc cgagcccgag 11460 ggtcgctggc tgctggagct gatcaacatc ttgcagagca tcgtagtgca ggagcgcagc 11520 ctgagcttgg ccgagaaggt ggcggcgatc aactactcgg tgctgagcct gggcaagttt 11580 tacgcgcgca agatttacaa gacgccgtac gtgcccatag acaaggaggt gaagatagac 11640 agcttttaca tgcgcatggc gctcaaggtg ctgacgctga gcgacgacct gggcgtgtac 11700 cgcaacgacc gcatccacaa ggccgtgagc acgagccggc ggcgcgagct aagcgaccgc 11760 gagctgatgc tgagcctgcg ccgggcgctg gtagggggcg ctgccggcgg cgaggagtcc 11820 tacttcgaca tgggggcgga cctgcattgg cagccgagcc ggcgcgcctt ggaggccgcc 11880 tacggtccag aggacttgga tgaggaagag gaagaggagg aggatgcacc cgctgcgggg 11940 tactgacgcc tccgtgatgt gtttttagat gcagcaagcc ccggaccccg ccataagggc 12000 ggcgctgcaa agccagccgt ccggtctagc atcggacgac tgggaggccg cgatgcaacg 12060 catcatggcc ctgacgaccc gcaaccccga gtcctttaga caacagccgc aggccaacag 12120 actctcggcc attctggagg cggtggtccc ctctcggacc aaccccacgc acgagaaggt 12180 gctggcgatc gtgaacgcgc tggcggagaa caaggccatc cgtcccgacg aggccgggct 12240 ggtgtacaac gccctgctgg agcgcgtggg ccgctacaac agcacgaacg tgcagtccaa 12300 cctggaccgg ctggtgacgg acgtgcgcga ggccgtggcg cagcgcgagc ggttcaagaa 12360 cgagggcctg ggctcgctgg tggcgctgaa cgccttcctg gcgacgcagc cggcgaacgt 12420 gccgcgcggg caggacgatt acaccaactt tatcagcgcg ctgcggctga tggtgaccga 12480 ggttccccag agcgaggtgt accagtcggg cccggactac tttttccaga cgagccggca 12540 gggcttgcag acggtgaacc tgagccaggc tttcaagaac ctgcgagggc tgtggggcgt 12600 gcaggcgccc gtgggcgacc ggtcgacggt gagcagcttg ctgacgccca actcgcggct 12660 gctgctgctg ctgatcgcgc ccttcaccga cagcggcagc gtgaaccgca actcgtacct 12720 gggccatctg ctgacgctgt accgcgaggc cataggccag gcgcaggtgg acgagcagac 12780 cttccaggag atcactagcg tgagccgcgc gctggggcag aacgacaccg acagtctgag 12840 ggccaccctg aacttcttgc tgaccaatag acagcagaag atcccggcgc aatatgcgct 12900 gtcggccgag gaggaaagga tcctgagata tgtgcagcag agcgtagggc tgttcctgat 12960 gcaggagggg gccaccccca gcgccgcgct ggacatgacc gcgcgcaaca tggaacctag 13020 catgtacgcc gccaaccggc cgttcatcaa taagctgatg gactacctgc accgcgcggc 13080 ggtcatgaac acggactact ttacaaacgc catcctgaac ccgcactggc tcccgccgcc 13140 ggggttctac acgggcgagt acgacatgcc cgaccccaac gacgggttcc tgtgggacga 13200 cgtggacagc gtggtgttct cgccgacctt tcaaaagcgc caggaggcgc cgccgagcga 13260 gggcgcggtg gggaggagcc cctttcctag cttagggagt ttgcatagct tgccgggctc 13320 ggtgaacagc ggcagggtga gccggccgcg cttgctgggc gaggacgagt acctgaacga 13380 ctcgctgctg cagccgccgc gggccaagaa cgccatggcc aataacggga tagagagtct 13440 ggtggacaaa ctgaaccgtt ggaagaccta cgctcaggac catagggatg cgcccgcgcc 13500 gcggcgacag cgccacgacc ggcagcgggg cctggtgtgg gacgacgagg actcggccga 13560 cgatagcagc gtgttggact tgggcgggag cggtggggtc aacccgttcg cgcatctgca 13620 gcccaaactg gggcgacgga tgttttgaaa tgcaaaataa aactcaccaa ggccatagcg 13680 tgcgttctct tccttgttag agatgaggcg tgcggtggtg tcttcctctc ctcctccctc 13740 gtacgagagc gtgatggcgc aggcgaccct ggaggttccg tttgtgcctc cgcggtatat 13800 ggctcctacg gagggcagaa acagcattcg ttactcggag ctggctccgc agtacgacac 13860 cactcgcgtg tacttggtgg acaacaagtc ggcggacatc gcttccctga actaccaaaa 13920 cgaccacagc aacttcctga ccacggtggt gcagaacaac gatttcaccc ccgccgaggc 13980 cagcacgcag acgataaatt ttgacgagcg gtcgcggtgg ggcggtgatc tgaagaccat 14040 tctgcacact aacatgccca atgtgaacga gtacatgttc accagcaagt ttaaggcgcg 14100 ggtgatggtg gctaggaagc atccagaggg ggtagttgaa acagatttga gtcaggataa 14160 gcttgaatat gagtggtttg agtttaccct gcccgaggga aacttttccg agaccatgac 14220 catagacctg atgaacaacg ccatcttgga aaactacttg caagtggggc ggcaaaatgg 14280 cgtgctggag agcgatatcg gagtcaagtt tgacagcaga aatttcaagc tgggctggga 14340 cccggtgacc aagctggtga tgccaggggt ctacacctac gaggccttcc acccggacgt 14400 ggtgctgctg ccgggctgcg gggtggactt caccgagagc cgcctgagca acctcctggg 14460 cattcgcaag aagcaacctt tccaagaggg cttcagaatc atgtatgagg atctagaagg 14520 tggcaacatc cccgccctcc ttgatgtgcc caagtacttg gaaagcaaga agaaagttga 14580 agacgaaact aaaaatgcag ctgcggctac agccgataca accactaggg gtgatacatt 14640 tgcaactcca gcgcaagaga cagcagctga taagaaggta gaagtcttgc ccattgaaaa 14700 ggatgagagt ggtagaagtt acaacctgat ccaggggacc cacgacacgc tgtaccgcag 14760 ttggtacctg tcctatacct acggggaccc cgagaagggg gtgcagtcgt ggacgctgct 14820 caccaccccg gacgtcacct gcggcgcgga gcaagtctac tggtcgctgc cggacctcat 14880 gcaagaccca gtcaccttcc gctctaccca gcaagtcagc aactaccccg tggtcggcgc 14940 cgagctcatg cccttccgcg ccaagagctt ttacaacgac ctcgccgtct actcccagct 15000 catccgcagc tacacctccc tcacccacgt cttcaaccgc ttccccgaca accagatcct 15060 ctgccgcccg cccgcgccca ccatcaccac cgtcagtgaa aacgtgcctg ctctcacaga 15120 tcacgggacg ctaccgctgc gcagcagtat ccgcggagtc cagcgagtga ccgtcactga 15180 cgcccgtcgc cgcacctgtc cctacgtcta caaggccctg ggcatagtcg cgccgcgcgt 15240 gctttccagt cgcaccttct aaaaaaatgt ctattctcat ctcgcccagc aataacaccg 15300 gctggggtct tactagaccc agcaccatgt acggaggagc caagaagcgc tcccagcagc 15360 accccgtccg cgtccgcggc cacttccgcg ctccctgggg cgcttacaag cgcgggcgga 15420 cttccaccgc cgtgcgcacc accgtcgacg acgtcatcga ctcggtggtc gccgacgcgc 15480 gcaactatac ccccgccccc tccaccgtgg acgcggtcat cgacagcgtg gtggccgacg 15540 cgcgcgacta tgccagacgc aagagccggc ggcgacggat cgccaggcgc caccggagca 15600 cgcccgccat gcgcgccgcc cgggctctgc tgcgccgcgc cagacgcacg ggccgccggg 15660 ccatgatgcg agccgcgcgc cgcgctgcca ctgcacccac ccccgcaggc aggactcgca 15720 gacgagcggc cgccgccgcc gccgcggcca tctctagcat gaccagaccc aggcgcggaa 15780 acgtgtactg ggtgcgcgac tccgtcacgg gcgtgcgcgt gcccgtgcgc acccgtcctc 15840 ctcgtccctg atctaatgct tgtgtcctcc cccgcaagcg acgatgtcaa agcgcaaaat 15900 caaggaggag atgctccagg tcgtcgcccc ggagatttac ggaccacccc aggcggacca 15960 gaaaccccgc aaaatcaagc gggttaaaaa aaaggatgag gtggacgagg gggcagtaga 16020 gtttgtgcgc gagttcgctc cgcggcggcg cgtaaattgg aaggggcgca gggtgcagcg 16080 cgtgttgcgg cccggcacgg cggtggtgtt cacgcccggc gagcggtcct cagtcaggag 16140 caagcgtagc tatgacgagg tgtacggcga cgacgacatc ctggaccagg cggcggagcg 16200 ggcgggcgag ttcgcctacg ggaagcggtc gcgcgaagag gagctgatct cgctgccgct 16260 ggacgaaagc aaccccacgc cgagcctgaa gcccgtgacc ctgcagcagg tgctgcccca 16320 ggcggtgctg ctgccgagcc gcggggtcaa gcgcgagggc gagagcatgt acccgaccat 16380 gcagatcatg gtgcccaagc gccggcgcgt ggaggacgtg ctggacaccg tgaaaatgga 16440 tgtggagccc gaggtcaagg tgcgccccat caagcaggtg gcgccgggcc tgggcgtgca 16500 gaccgtggac attcagatcc ccaccgacat ggatgtcgac aaaaaaccct cgaccagcat 16560 cgaggtgcag accgacccct ggctcccagc ctccactgct accgtctcca cttctaccgc 16620 cgccacggct accgagcctc ccaggaggcg aagatggggc gccgccagcc ggctgatgcc 16680 caactacgtg gtgcatcctt ccatcatccc gacgccgggc taccgcggca cccggtacta 16740 cgccagccgc cggcgcccag ccagcaaacg ccgccgccgc accgccaccc gccgccgtct 16800 ggcccccgcc cgcgtgcgcc gcgtgaccac gcgccggggc cgctcgctcg ttctgcccac 16860 cgtgcgctac caccccagca tcctttaatt cgtgtgctgt gatactgttg cagagagatg 16920 gctctcactt gccgcctgcg catccccgtc ccgaattacc gaggaagatc ccgccgcagg 16980 agaggcatgg caggcagcgg cctgaaccgc cgccggcggc gggccatgcg caggcgcctg 17040 agtggcggct ttctgcccgc gctcatcccc ataatcgccg cggccatcgg cacgatcccg 17100 ggcatagctt ccgttgcgct gcaggcgtcg cagcgccgtt gatgtgcgaa taaaagcctc 17160 tttagactct gacacacctg gtcctgtata tttttagaat ggaagacatc aattttgcgt 17220 ccctggctcc gcggcacggc acgcggccgt tcatgggcac ctggaacgag atcggcacca 17280 gccagctgaa cgggggcgcc ttcaattgga gcagtgtctg gagcgggctt aaaaatttcg 17340 gctcgacgct ccggacctat gggaacaagg cctggaatag tagcacgggg cagttgctaa 17400 gggaaaagct caaagaccag aactttcagc agaaggtggt ggacgggctg gcctcgggca 17460 ttaacggggt ggtggacatc gcgaaccagg ccgtgcagcg cgagataaac agccgcctgg 17520 acccgcggcc gcccacggtg gtggagatgg aagatgcaac tcttccgccg cccaaaggcg 17580 agaagcggcc gcggcccgac gcggaggaga cgatcctgca ggtggacgag ccgccctcgt 17640 acgaggaggc cgtcaaggcc ggcatgccca ccacgcgcat catcgcgccg ctggccacgg 17700 gtgtaatgaa acccgccacc cttgacctgc ctccaccacc cgcgcccgct ccaccgaagg 17760 cagctcccgc ggtcgtgcag gcccccccgg tggcgaccgc cgtgcgccgc gtccccgccc 17820 gccgccaggc ccagaactgg cagagcacgt tgcacagtat cgtaggcctg ggagtgaaaa 17880 gtctgaagcg ccgccgatgc tattgaaaga gaggaaagag gacactaaag ggagagctta 17940 acttgtatgt gccttaccgc cagagaacgc gcgaagatgg ccaccccctc gatgatgccg 18000 cagtgggcgt acatgcacat cgccgggcag gacgcctcgg agtacctgag cccgggtctg 18060 gtgcagtttg cccgcgccac cgacacgtac ttcagcctgg gcaacaagtt taggaacccc 18120 acggtggccc cgacccacga tgtgaccacg gaccggtccc agcgtctgac gctgcgcttc 18180 gtgcccgtgg atcgcgagga caccacgtac tcgtacaagg cgcgcttcac tctggccgtg 18240 ggcgacaacc gggtgctaga catggccagc acttactttg acatccgcgg cgtcctggac 18300 cgcggtccca gcttcaaacc ctactcgggc acagcttaca acagtctggc ccccaagggt 18360 gcccccaact ccagccagtg gcttgcaaaa gacaccaatg ctggcgatca agcattaaaa 18420 acccacacac atggcgtagc tgctatgggg ggaacagata tcacagcaaa gggtttgcaa 18480 attggtgttg acacgactga aaacaagaat gagcctattt atgcaaatga aatataccag 18540 ccagaacctc aggtaggaga ggaaaacttg caagatgttg aaaactttta tggaggcaga 18600 gctcttaaaa aagaaaccaa aatgaaacct tgctatggct cgtttgccag acccacaaat 18660 gaaaaaggcg gtcaagccaa atttttaact gacggcgatg gtcagctaac taaaaatcat 18720 gatatcacaa tgaatttctt tgacactcct ggaggaacag ttggtcagga tactgaactt 18780 gaagcagaca ttgttatgta tgctgagaat gtgcatctgg aaactccaga cacgcatgtg 18840 gtgtacaaac caggaacttc tgatgagagt tcagaagcaa atttggttca gcagtccatg 18900 ccaaacaggc ccaactacat cggcttcagg gacaactttg tgggtctcat gtactataac 18960 agcactggca acatgggtgt gctggctggt caagcatctc agttgaatgc tgtggtcgac 19020 ttgcaagaca gaaacacaga gctgtcttac cagctcttgc tagattctct gggtgacaga 19080 accagatact ttagcatgtg gaactctgca gtggacagtt atgatcctga tgtcaggatt 19140 attgaaaatc acggtgtgga agatgaactt ccaaactatt gcttcccatt ggatggagct 19200 ggcactaatg ctacctacca aggtgtaaaa gttaaaaatg gccaagatgg agatgtaaac 19260 gcagattggg aaaaagatcc aaatcttgct tcacgaaacc aaatatgcaa gggtaacatc 19320 ttcgccatgg agatcaacct ccaggccaac ctgtggaaga gttttctgta ctcgaatgtg 19380 gccctgtacc tgcccgactc atacaagtac acgccggcca acgtcacgct gcccgccaat 19440 accaacacct acgagtacat gaacggccgc gtggtagccc cctcgctggt ggacgcctac 19500 atcaacatcg gcgcccggtg gtcgctggac cccatggaca acgtcaaccc attcaaccac 19560 caccgcaacg cgggcctgcg ttaccgctcc atgcttctgg gcaacggccg ctacgtgccc 19620 ttccacatcc aagtgcccca aaagttcttt gccatcaaga acctgctcct gctccccggc 19680 tcctacacct acgagtggaa cttccgcaag gatgtcaaca tgatcctgca gagttccctc 19740 ggaaacgacc tgcgcgtcga cggcgcctcc gtccgcttcg acagcgtcaa cctctacgcc 19800 acattcttcc ccatggcgca caacaccgcc tccaccctgg aagccatgct gcgcaacgac 19860 accaacgacc agtccttcaa cgactacctc tcggccgcca acatgctcta ccccatcccg 19920 gccaaggcca ccaacgtgcc catctccatc ccctcgcgca actgggccgc cttccgcggc 19980 tggagtttca cccggctcaa gaccaaagaa actccctccc tcggctcggg tttcgatccc 20040 tactttgtat actcgggttc catcccctac ctcgacggga ccttctacct caaccacacc 20100 ttcaagaagg tctccatcat gttcgactcc tcggtcagct ggcccggcaa cgaccggctg 20160 ctcacgccga acgagttcga gatcaagcgc agtgtcgacg gggagggcta caatgtggcc 20220 caatgcaaca tgaccaagga ctggttcctc gtccagatgc tctcccacta caacatcggc 20280 taccagggct tccacgtgcc cgagggctac aaggaccgca tgtactcctt cttccgcaac 20340 ttccagccca tgagcaggca ggtggtcgat gagatcaact acaaggacta caaggccgtc 20400 accctgccct tccagcacaa caactcgggc ttcaccggct accttgcacc caccatgcgt 20460 caggggcagc cctaccccgc caacttcccc tatcctctca tcggccagac agccgtgccc 20520 tctgtcaccc agaaaaagtt cctctgcgac agggtcatgt ggcgcatccc cttctccagc 20580 aacttcatgt ccatgggcgc cctcaccgac ctgggtcaga acatgctcta tgccaactcg 20640 gcccacgcgc tcgacatgac cttcgaggtg gaccccatgg atgagcccac cctcctctat 20700 cttctcttcg aagttttcga cgtggtcaga gtgcaccagc cgcaccgcgg cgtcatcgag 20760 gccgtctacc tgcgcacgcc cttctccgcc ggcaacgcca ccacctaagc atgagcggct 20820 ccagcgaacg agagctcgcg gccatcgtgc gcgacctggg ctgcgggccc tactttttgg 20880 gcacccacga caagcgcttc ccgggcttcc tcgccggcga caagctggcc tgcgccattg 20940 tcaacacggc cggccgcgag accggaggcg tgcactggct cgccttcggc tggaacccgc 21000 gctcgcgcac ctgctacatg ttcgacccat ttgggttctc ggaccgccgg ctcaagcaga 21060 tttacagctt cgagtacgag gctatgttgc gccgaagcgc cctggcttcc tcgcccgacc 21120 gctgtctcag cctcgagcag tccacccaga ccgtgcaggg gcccgactcc gccgcctgcg 21180 gacttttctg ttgcatgttc ttgcatgcct tcgtgcactg gcccgaccga cccatggacg 21240 ggaaccccac catgaacttg ctgacggggg tgcccaacgg catgctacaa tcgccacagg 21300 tgctgcccac cctccggcgc aaccaggagg agctctaccg cttcctcgcg cgccactccc 21360 cttactttcg ctcccaccgc gccgccatcg aacacgccac cgcttttgac aaaatgaaac 21420 aactgcgtgt atctcaataa acagcacttt tattttacat gtactggagt atatgcaagt 21480 tatttaaaag tcgaaggggt tctcgcgctc gtcgttgtgc gccgcgctgg ggagggccac 21540 gttgcggtac tggaacttgg gctgccactt gaactcgggg atcaccagtt tgggcactgg 21600 ggtctcgggg aaggtctcgc tccacatgcg ccggctcatc tgcagggcgc ccagtatgtc 21660 cggggcggag atcttgaaat cgcagttggg gccggtgctc tgcgcgcgcg agttgcggta 21720 cacggggttg cagcactgga acaccatcag actggggtac ttcacactgg ccagcacgct 21780 cttgtcgctg atctgatcct tgtccaggtc ctcggcgttg ctcaggccga acggggtcat 21840 cttgcacagc tggcggccca ggaagggcac gctctgaggc ttgtggttac actcgcagtg 21900 cacgggcatc agcatcatcc ccgcgccgcg ctgcatattc gggtagaggg ccttgacaaa 21960 ggccgagatc tgcttgaaag cttgctgggc cttggccccc tcgctgaaaa acaggccgca 22020 gctcttcccg ctgaactggt tattcccgca cccggcatca tgcacgcagc agcgcgcgtc 22080 atggctggtc agttgcacca cgctccgtcc ccagcggttc tgggtcacct tggccttgct 22140 aggctgctcc ttcaacgcgc gctggccgtt ctcgctggtc acatccatct ccaccacgtg 22200 gtccttgtgg atcatcaccg tcccgtgcaa acacttgagc tggccttcca cctcggtgca 22260 gccgtgatcc cacagggcgc agccggtgca ctcccaattc ttgtgtgcga tcccgctgtg 22320 gctgaagatg taaccttgca acaggcgacc catgacggtg ctaaatgatt tactggtgct 22380 gaaggtcagt tgcagaccgc gggcctcctc gttcatccag gtctggcaca tcttttggaa 22440 gatctcggtc tgctcgggca tgagcttgta agcatcgcgc aggccgctgt cgacgcggta 22500 gcgttccata agcacgttca tggtatccat gcccttctcc caggacgaga ccagaggcag 22560 actcaggggg ttgcgcacgt tcagaatacc gggggtcgcg ggctcgacga tgcgttttcc 22620 gtccttgcct tccttcaaca gaaccggcgg ctggctgaat cccactccca cgatcacggc 22680 atcttcctgg ggcatctctt cgtcggggtc taccttggtc acatgcttgg tctttctggc 22740 ttgcttcttt tttggagggc tgtccacggg gaccacgtcc tcctcggaag acccggagcc 22800 cacccgctga tactttcggc gcttggtggg cagaggaggt ggaggcgagg ggctcctctc 22860 ctgctccggc ggatagcgcg ccgacccgtg gccccggggc ggagtggcct ctcgctccat 22920 gaaccggcgc acgtcctgac tgccgccggc cattgtttcc taggggaaga tggaggagca 22980 gccgcgtaag caggagcagg aggaggactt aaccacccac gagcaaccca aaatcgagca 23040 ggacctgggc ttcgaagagc cggctcgtct agaaccccca caggatgaac aggagcacga 23100 gcaagacgca ggccaggagg agaccgacgc tgggctcgag catggctacc tgggaggaga 23160 ggaggatgtg ctgctgaaac acttgcagcg ccagtccctc atcctccggg acgccctggc 23220 cgaccggagc gaaacccccc tcagcgtcga ggagctgtgt cgggcctacg agctcaacct 23280 cttctcgccg cgcgtgcccc ccaaacgcca gcccaacggc acctgcgagc ccaacccgcg 23340 tctcaacttc tatcccgttt tcgcggtccc cgaggccctt gccacctatc acattttttt 23400 caagaaccaa aagatccccg tctcctgccg cgccaaccgc acccgcgccg acgcgctcct 23460 cgctctgggg cccggcgcgc gcatacctga tatcgcttcc ctggaagagg tgcccaagat 23520 cttcgaaggg ctcggtcggg acgagacgcg cgcggcgaac gctctgaaag aaacagcaga 23580 ggaagagggt cacactagcg ccctggtaga gttggaaggc gacaacgcca ggctggccgt 23640 gctcaagcgc agcgtcgagc tcacccactt tgcctacccc gccgtcaacc tcccgcccaa 23700 ggtcatgcgt cacatcatgg atcagctcat catgccccac atcgaagccc tcgatgaaag 23760 tcaggagcag cgccccgagg acgcccgacc cgtggtcagc gacgagatgc tcgcgcgctg 23820 gctcgggacc cgcgagcccc aggctttgga acagcggcgc aagctcatgc tggccgtggt 23880 cctggtcacc ctcgagctcg aatgcatgcg ccgcttcttc agcgaccccg agaccctgcg 23940 caaagtcgag gagaccctgc actacacttt cagacacggt ttcgtcaggc aggcctgcaa 24000 gatttccaac gtggagctga ccaacctggt ctcctgcctg gggatcctgc atgagaaccg 24060 cctgggacag accgtactcc actctaccct gaagggcgag gcgcggaggg actatgtccg 24120 cgactgcgtc tttctctttc tctgccacac atggcaagca gccatgggcg tgtggcagca 24180 gtgtctcgag gacgagaacc tgaaggagct ggacaagctt cttgctagaa accttaaaaa 24240 gctttggacg ggcttcgacg agcgcaccgt cgcctcggac ctggccgaga tcgtcttccc 24300 cgagcgcctg aggcagacgc tgaaaggcgg gctgcccgac ttcatgagcc agagcatgtt 24360 gcaaaactac cgcactttca ttctcgagcg atcggggatg ctgcccgcca cctgcaacgc 24420 tttcccctcc gactttgtcc cgctgagcta ccgcgagtgt cccccgccgc tgtggagcca 24480 ctgctacctc ttgcagctgg ccaactacat cgcctaccac tcggacgtga tcgaggacgt 24540 gagcggcgag gggctgctcg agtgccactg ccgctgcaac ctgtgctccc cgcaccgctc 24600 cctggtctgc aacccccagc tccttagcga gacccaggtc atcggtacct tcgagctgca 24660 aggtccgcag gagtccaccg ctccgctgaa actcacgccg gggttgtgga cttccgcgta 24720 cctgcgcaaa tttgtacccg aggactacca cgcccatgag ataaagttct tcgaggacca 24780 atcgcggccg cagcacgcgg atctcacggc ctgcgtcatc acccagggcg cgatcctcgc 24840 ccaattgcac gccatccaaa aatcccgcca agagtttctt ctgaaaaagg gtagaggggt 24900 ctacctggac ccccagacgg gcgaggtgct caacacgggt ctcccccagc atgccgagga 24960 agaagcagga gccgctagtg gaggagatgg aagaagaatg ggacagccag gcagaggagg 25020 acgaatggga ggaggagaca gaggaggaag aattggaaga ggtggaagag gagcaggcaa 25080 cagagcagcc cgtcgccgca ccatccgcgc cggcagcccc ggcggtcacg gatacaacct 25140 ccgcagctcc ggccaagcct cctcgtagat gggatcgagt gaagggcgac ggtaagcacg 25200 agcggcaggg ctaccgatca tggagggccc acaaagccgc gatcatcgcc tgcttgcaag 25260 actgcggggg gaacatcgct ttcgcccgcc gctacctgct cttccaccgc ggggtgaaca 25320 tcccccgcaa cgtgttgcat tactaccgtc accttcacag ctaagaaaaa gcaagtaaga 25380 gaagtcgccg gaggaggcct gaggatcgcg gcgaacgagc ccttgaccac cagggagctg 25440 aggaaccgga tcttccccac tctttatgcc atttttcagc agagtcgagg tcagcagcaa 25500 gagctcaaag taaaaaaccg gtctctgcgc tcgctcaccc gcagttgctt gtaccacaaa 25560 aacgaagatc agctgcagcg cactctcgaa gacgccgagg ctctgttcca caagtactgc 25620 gcgctcactc ttaaagacta aggcgcgccc acccggaaaa aaggcgggaa ttacctcatc 25680 gccaccatga gcaaggagat tcccacccct tacatgtgga gctatcagcc ccagatgggc 25740 ctggccgcgg gcgcctccca agactactcc acacgcatga actggctcag tgccggcccc 25800 tcgatgatat cacgggtcaa cggggtccgc agtcatcgaa accagatatt gttggagcag 25860 gcggcggtca cctccacgcc cagggcaaag ctcaacccgc gtaattggcc ctccaccctg 25920 gtgtatcagg aaatccccgg gccgactacc gtactacttc cgcgtgacgc actggccgaa 25980 gtccgcatga ctaactcagg tgtccagctg gccggcggcg cttcccggtg cccgctccgc 26040 ccacaatcgg gtataaaaac cctggtgatc cgaggcagag gcacacagct caacgacgag 26100 ttggtgagct cttcgatcgg tctgcgaccg gacggagtgt tccaactagc cggagccggg 26160 agatcgtcct tcactcccaa ccaggcctac ctgaccttgc agagcagctc ttcggagcct 26220 cgctcgggag gcatcggaac cctccagttc gtggaggagt ttgtgccctc ggtctacttc 26280 aaccccttct cgggatcgcc aggcctctac ccggacgagt tcataccgaa cttcgacgca 26340 gtgagagaag cggtggacgg ctacgactga ttaatgttaa gtggagaggc agagcaactg 26400 cgcctgaaac acctggtcca ctgtcgccgc cacaagtgct ttgcccgcga ctccggtgag 26460 ttttgctact ttgaattgcc cgaggatcat atcgagggcc cggcgcacgg cgtccggctt 26520 accgcccagg gagagcttgc ccgtagcctg attcgggagt ttacccagcg ccccctgcta 26580 gttgagcggg acaggggacc ctgtgttctc actgtgattt gcaactgtcc taaccctgga 26640 ttacatcaag atctttgttg ccatctctgt gctgagtata ataaatacag aaattaaaat 26700 atactggggc tcctatcgcc atcctgtaaa cgccaccgtc ttcacccgcc caagcaaacc 26760 aaggcgaacc ttacctggta cttttaacat ctctccctct gtgatttaca acagtttcaa 26820 cccagacgga gtgagtctac gagagaacct ctccgagctc agctactcca tcagaaaaaa 26880 caccaccctc cttacctgcc gggaacgtac gagtgcgtca ccggccgctg caccacacct 26940 accgcctgac cgtaaaccag actttttccg gacagacctc aataactctg tttaccagaa 27000 caggaggtga gcttagaaaa cccttagggt attaggccaa aggcgcagct actgtggggt 27060 ttatgaacaa ttcaagcaac tctacgggct attctaattc aggtttctct agaatcgggg 27120 ttggggttat tctctgtctt gtgattctct ttattcttat actaacgctt ctctgcctaa 27180 ggctcgccgc ctgctgtgtg cacatttgca tttattgtca gctttttaaa cgctggggtc 27240 gccacccaag atgattaggt acataatcct aggtttactc acccttgcgt cagcccacgg 27300 taccacccaa aaggtggatt ttaaggagcc agcctgtaat gttacattcg cagctgaagc 27360 taatgagtgc accactctta taaaatgcac cacagaacat gaaaagctgc ttattcgcca 27420 caaaaacaaa attggcaagt atgctgttta tgctatttgg cagccaggtg acactacaga 27480 gtataatgtt acagttttcc agggtaaaag tcataaaact tttatgtata cttttccatt 27540 ttatgaaatg tgcgacatta ccatgtacat gagcaaacag tataagttgt ggcccccaca 27600 aaattgtgtg gaaaacactg gcactttctg ctgcactgct atgctaatta cagtgctcgc 27660 tttggtctgt accctactct atattaaata caaaagcaga cgcagcttta ttgaggaaaa 27720 gaaaatgcct taatttacta agttacaaag ctaatgtcac cactaactgc tttactcgct 27780 gcttgcaaaa caaattcaaa aagttagcat tataattaga ataggattta aaccccccgg 27840 tcatttcctg ctcaatacca ttcccctgaa caattgactc tatgtgggat atgctccagc 27900 gctacaacct tgaagtcagg cttcctggat gtcagcatct gactttggcc agcacctgtc 27960 ccgcggattt gttccagtcc aactacagcg acccacccta acagagatga ccaacacaac 28020 caacgcggcc gccgctaccg gacttacatc taccacaaat acaccccaag tttctgcctt 28080 tgtcaataac tgggataact tgggcatgtg gtggttctcc atagcgctta tgtttgtatg 28140 ccttattatt atgtggctca tctgctgcct aaagcgcaaa cgcgcccgac cacccatcta 28200 tagtcccatc attgtgctac acccaaacaa tgatggaatc catagattgg acggactgaa 28260 acacatgttc ttttctctta cagtatgatt aaatgagaca tgattcctcg agtttttata 28320 ttactgaccc ttgttgcgct tttttgtgcg tgctccacat tggctgcggt ttctcacatc 28380 gaagtagact gcattccagc cttcacagtc tatttgcttt acggatttgt caccctcacg 28440 ctcatctgca gcctcatcac tgtggtcatc gcctttatcc agtgcattga ctgggtctgt 28500 gtgcgctttg catatctcag acaccatccc cagtacaggg acaggactat agctgagctt 28560 cttagaattc tttaattatg aaatttactg tgacttttct gctgattatt tgcaccctat 28620 ctgcgttttg ttccccgacc tccaagcctc aaagacatat atcatgcaga ttcactcgta 28680 tatggaatat tccaagttgc tacaatgaaa aaagcgatct ttccgaagcc tggttatatg 28740 caatcatctc tgttatggtg ttctgcagta ccatcttagc cctagctata tatccctacc 28800 ttgacattgg ctggaacgca atagatgcca tgaaccaccc aactttcccc gcgcccgcta 28860 tgcttccact gcaacaagtt gttgccggcg gctttgtccc agccaatcag cctcgcccac 28920 cttctcccac ccccactgaa atcagctact ttaatctaac aggaggagat gactgacacc 28980 ctagatctag aaatggacgg aattattaca gagcagcgcc tgctagaaag acgcagggca 29040 gcggccgagc aacagcgcat gaatcaagag ctccaagaca tggttaactt gcaccagtgc 29100 aaaaggggta tcttttgtct ggtaaagcag gccaaagtca cctacgacag taataccacc 29160 ggacaccgcc ttagctacaa gttgccaacc aagcgtcaga aattggtggt catggtggga 29220 gaaaagccca ttaccataac tcagcactcg gtagaaaccg aaggctgcat tcactcacct 29280 tgtcaaggac ctgaggatct ctgcaccctt attaagaccc tgtgcggtct caaagatctt 29340 attcccttta actaataaaa aaaaataata aagcttatca cttacttgaa atctgaaagt 29400 atgtctctgg tgtagttgtt cagcagcacc tcgttaccct cctcccagct ctggtattcc 29460 agtccccggc gggcggcgaa cttcctccac accttgaaag ggatgtcaaa ttcctggtcc 29520 acaattttca ttgtcttccc tctcagatgt caaagaggct ccgggtggaa gatgacttca 29580 accccgtcta cccctatggc tacgcgcgga atcagaatat ccccttcctc actcccccct 29640 ttgtctcctc cgatggattc caaaacttcc cccctggggt cctgtcactc aaactggctg 29700 acccaatagc catcgtcaat gggaatgtct cactcaaagt gggagggggt ctcactttgc 29760 aagatggaac tggaaaacta acagtcaatg ctgatccacc tttgcaactt acaaacaaca 29820 aattagggat tgctttggac gctccatttg atgttataga caataaactc acattgttag 29880 cgggccatgg cttgtctatt ataacaaaag aaacatcaac actgcctggc ttgattaata 29940 ctcttgtagt attaactgga aagggtattg gaacagaatc aacagataat ggcggaagcg 30000 tatgtgttag agttggagaa ggtggcggct tatcatttaa taatgatgga gacttggtag 30060 catttaataa aaaagaagat aagcgcaccc tatggacaac tccagacaca tctccaaatt 30120 gcaagattga tcaagataag gactctaagt taactctggt ccttacaaag tgtggaagtc 30180 aaatattggc taatgtgtca ttaattgtcg tagctggtaa gtacaaaatt atcaataaca 30240 atactcaacc agctctcaaa ggatttacca ttaaattatt gtttgatgaa aatggagtac 30300 ttatggaatc ttcaaatctt ggtaaatcat attggaactt tagaaatgaa aattcaatta 30360 tgtcaacagc ttatgaaaaa gctattggat tcatgcctaa tttggtagcc tatccaaaac 30420 ctaccgctgg ctctaaaaaa tatgcaagag atatagttta tggaaacatc taccttggtg 30480 gaaagccaga tcaaccagta accattaaaa ctacctttaa tcaggaaact ggatgtgaat 30540 attctatcac atttgatttt agttgggcca agacttatgt aaatgttgaa tttgaaacaa 30600 cctcttttac cttttcctat atcgcccaag aataataaag aatcgtttgt gttatgtttc 30660 aacgtgttta tttttcaatt gcagaaaatt tcgaatcatt tttcattcag tagtatagcc 30720 ccaccaccac atagcttata cagatcaccg taccttaatc aaacctacat gggggtagag 30780 tcataatcgt gcatcaggat agggcggtgg tgctgcagca gcgcgcgaat aaactgctgc 30840 cgccgccgct ccgtcctgca ggaatacaac atggcagtgg tctcctcagc gatgattcgc 30900 accgcccgca gcataaggcg ccttgtcctc cgggcacagc agcgcaccct gatctcactt 30960 aaatcagcac agtaactgca gcacagcacc acaatattgt tcaaaatccc acagtgcaag 31020 gcgctgtatc caaagctcat ggcggggacc acagaaccca cgtggccatc ataccacaag 31080 cgcaggtaga ttaagtggcg acccctcata aacacgctgg acataaacat tacctctttt 31140 ggcatgttgt aattcaccac ctcccggtac catataaacc tctgattaaa catggcgcca 31200 tccaccacca tcctaaacca gctggccaaa acctgcccgc cggctataca ctgcagggaa 31260 ccgggactgg aacaatgaca gtggagagcc caggactcgt aaccatggat catcatgctc 31320 gtcatgatat caatgttggc acaacacagg cacacgtgca tacacttcct caggattaca 31380 agctcctccc gcgttagaac catatcccag ggaacaaccc attcctgaat cagcgtaaat 31440 cccacactgc agggaagacc tcgcacgtaa ctcacgttgt gcattgtcaa agtgttacat 31500 tcgggcagca gcggatgatc ctccagtatg gtagcgcggg tttctgtctc aaaaggaggt 31560 agacgatccc tactgtacgg agtgcgccga gacaaccgag atcgtgttgg tcgtagtgtc 31620 atgccaaatg gaacgccgga cgtagtcata tttcctgaag caaaaccagg tgcgggcgtg 31680 acaaacagat ctgcgtctcc ggtctcgccg cttagatcgc tctgtgtagt agttgtagta 31740 tatccactct ctcaaagcat ccaggcgccc cctggcttcg ggttctatgt aaactccttc 31800 atgcgccgct gccctgataa catccaccac cgcagaataa gccacaccca gccaacctac 31860 acattcgttc tgcgagtcac acacgggagg agcgggaaga gctggaagaa ccatgttttt 31920 ttttttattc caaaagatta tccaaaacct caaaatgaag atctattaag tgaacgcgct 31980 cccctccggt ggcgtggtca aactctacag ccaaagaaca gataatggca tttgtaagat 32040 gttgcacaat ggcttccaaa aggcaaacgg ccctcacgtc caagtggacg taaaggctaa 32100 acccttcagg gtgaatctcc tctataaaca ttccagcacc ttcaaccatg cccaaataat 32160 tctcatctcg ccaccttctc aatatatctc taagcaaatc ccgaatatta agtccggcca 32220 ttgtaaaaat ctgctccaga gcgccctcca ccttcagcct caagcagcga atcatgattg 32280 caaaaattca ggttcctcac agacctgtat aagattcaaa agcggaacat taacaaaaat 32340 accgcgatcc cgtaggtccc ttcgcagggc cagctgaaca taatcgtgca ggtctgcacg 32400 gaccagcgcg gccacttccc cgccaggaac catgacaaaa gaacccacac tgattatgac 32460 acgcatactc ggagctatgc taaccagcgt agccccgatg taagcttgtt gcatgggcgg 32520 cgatataaaa tgcaaggtgc tgctcaaaaa atcaggcaaa gcctcgcgca aaaaagaaag 32580 cacatcgtag tcatgctcat gcagataaag gcaggtaagc tccggaacca ccacagaaaa 32640 agacaccatt tttctctcaa acatgtctgc gggtttctgc ataaacacaa aataaaataa 32700 caaaaaaaca tttaaacatt agaagcctgt cttacaacag gaaaaacaac ccttataagc 32760 ataagacgga ctacggccat gccggcgtga ccgtaaaaaa actggtcacc gtgattaaaa 32820 agcaccaccg acagctcctc ggtcatgtcc ggagtcataa tgtaagactc ggtaaacaca 32880 tcaggttgat tcacatcggt cagtgctaaa aagcgaccga aatagcccgg gggaatacat 32940 acccgcaggc gtagagacaa cattacagcc cccataggag gtataacaaa attaatagga 33000 gagaaaaaca cataaacacc tgaaaaaccc tcctgcctag gcaaaatagc accctcccgc 33060 tccagaacaa catacagcgc ttccacagcg gcagccataa cagtcagcct taccagtaaa 33120 aaagaaaacc tattaaaaaa acaccactcg acacggcacc agctcaatca gtcacagtgt 33180 aaaaaagggc caagtgcaga gcgagtatat ataggactaa aaaatgacgt aacggttaaa 33240 gtccacaaaa aacacccaga aaaccgcacg cgaacctacg cccagaaacg aaagccaaaa 33300 aacccacaac ttcctcaaat cgtcacttcc gttttcccac gttacgtcac ttcccatttt 33360 aagaaaacta caattcccaa cacatacaag ttactccgcc ctaaaaccta cgtcacccgc 33420 cccgttccca cgccccgcgc cacgtcacaa actccacccc ctcattatca tattggcttc 33480 aatccaaaat aaggtatatt attgatgatg 33510 <210> 95 <211> 34546 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO201X) <400> 95 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccttatgag 3600 tggaagcgct tcttttgagg ggggagtatt tagcccttat ctgacgggca ggctcccacc 3660 atgggcagga gttcgtcaga atgtcatggg atccactgtg gatgggagac ccgtccagcc 3720 cgccaattcc tcaacgctga cctatgccac tttgagttcg tcaccattgg atgcagctgc 3780 agccgccgcc gctactgctg ccgccaacac catccttgga atgggctatt atggaagcat 3840 cgttgccaat tccagttcct ctaataaccc ttcaaccctg gctgaggaca agctacttgt 3900 tctcttggcg cagctcgagg ccttaaccca acgcttaggc gaactgtcta agcaggtggc 3960 ccagttgcgt gagcaaactg agtctgctgt tgccacagca aagtctaaat aaaacataaa 4020 taaaaaacca gactctgttt ggatttggat caagcaaaat gaatgtttat ttgatttttc 4080 gcgcgcggta tgccctggac catcggtctc gatcattgag aacgcggtgg atcttttcca 4140 gtaccctgta aaggtgggat tgaatgttta gatacatggg cattagtccg tctcgggggt 4200 ggagatagct ccattgaaga gcctcttgct ccggggtagt gttataaatc acccagtcat 4260 agcaaggtcg gagtgcatgg tgttgcacaa tatcttttag gagcagacta attgcaacgg 4320 ggaggccctt agtgtaggtg tttacaaatc tgttgagctg ggacgggtgc atccggggtg 4380 aaattatatg cattttggac tggatcttga ggttggcaat gttgccgcct agatcccgtc 4440 tcgggttcat attgtgcagg accaccaaga cagtgtatcc ggtgcacttg ggaaatttat 4500 catgcagctt agagggaaaa gcatgaaaaa atttggagac gcctttgtga ccccccagat 4560 tctccatgca ctcatccata atgatagcga tggggccgtg ggcagcggca cgggcgaaca 4620 cgttccgggg gtctgaaaca tcatagttat gctcctgagt caggtcatca taagccattt 4680 taataaactt tgggcggagg gtgccagatt gggggatgaa agttccctct ggcccgggag 4740 catagtttcc ctcacatatt tgcatttccc aggctttcag ttcagagggg gggatcatgt 4800 ccacctgcgg ggctataaaa aataccgttt ctggagccgg ggtgattaac tgggacgaga 4860 gcaaattcct aagcagctga gacttgccgc acccagtggg accgtaaatg accccaatta 4920 cgggttgcag atggtagttt agggaacgac agctgccgtc ctcccggagc aggggggcca 4980 cttcgttcat catttccctt acatggatat tttcccgcac caagtccgtt aggaggcgct 5040 ctcccccaag ggatagaagc tcctggagcg aggagaagtt tttcagcggc ttcagcccgt 5100 cagccatggg cattttggaa agagtctgtt gcaagagctc gagccggtcc cagagctcgg 5160 tgatgtgctc tatggcatct cgatccagca gacctcctcg tttcgcgggt tgggacggct 5220 cctggagtag ggaatcagac gatgggcgtc cagcgctgcc agggtccgat ccttccatgg 5280 tcgcagcgtc cgagtcaggg ttgtttccgt cacggtgaag gggtgcgcgc ctggttgggc 5340 gcttgcgagg gtgcgcttca gactcatcct gctggtcgag aaccgctgcc gattggcgcc 5400 ctgcatgtcg gccaggtagc agtttaccat gagttcgtag ttgagcgcct cggccgcgtg 5460 gcctttggca cggagcttac ctttggaagt tttatggcag gcggggcagt agatacattt 5520 gagggcatac aacttgggcg cgaggaaaat ggattcgggg gagtatgcat ccgcaccgca 5580 ggaggcgcag acggtttcgc actccacgag ccaggtcaga tccggctcat cggggtcaaa 5640 aacaagtttt ccgccatgtt ttttgatgcg tttcttacct ttggtttcca tgagttcgtg 5700 tccccgctgg gtgacaaaga ggctgtccgt gtccccgtag accgacttta tgggcctgtc 5760 ctcgagcgga gtgcctcggt cctcttcgta gaggaaccca gcccactctg atacaaaagc 5820 gcgtgtccag gccagcacaa aggaggccac gtgggagggg tagcggtcgt tgtcaaccag 5880 ggggtccacc ttctctacgg tatgtaaaca catgtccccc tcctccacat ccaagaatgt 5940 gattggcttg taagtgtagg ccacgtgacc aggggtcccc gccggggggg tataaaaggg 6000 ggcgggcctc tgttcgtcct cactgtcttc cggatcgctg tccaggagcg ccagctgttg 6060 gggtaggtat tccctctcga aggcgggcat gacctctgca ctcaggttgt cagtttctag 6120 gaacgaggag gatttgatat tgacagtacc agcagagatg cctttcataa gactctcgtc 6180 catctggtca gaaaacacaa tcttcttgtt gtccagcttg gtggcaaatg atccatagag 6240 ggcattggat agaagcttgg cgatggagcg catggtttgg ttcttttcct tgtccgcgcg 6300 ctccttggcg gtgatgttaa gctggacgta ctcgcgcgcc acacatttcc attcaggaaa 6360 gatggttgtc agttcatccg gaactattct gattcgccat cccctattgt gcagggttat 6420 cagatccaca ctggtggcca cctcgcctcg gaggggctca ttggtccagc agagtcgacc 6480 tccttttctt gaacagaaag gggggagggg gtctagcatg aactcatcag gggggtccgc 6540 atctatggta aatattcccg gtagcaaatc tttgtcaaaa tagctgatgg tggcgggatc 6600 atccaaggtc atctgccatt ctcgaactgc cagcgcgcgc tcataggggt taagaggggt 6660 gccccagggc atggggtggg tgagcgcgga ggcatacatg ccacagatat cgtagacata 6720 gaggggctct tcgaggatgc cgatgtaagt gggataacat cgcccccctc tgatgcttgc 6780 tcgcacatag tcatagagtt catgtgaggg ggcaagaaga cccgggccca gattggtgcg 6840 gttgggtttt tccgccctgt aaacgatctg gcgaaagatg gcatgggaat tggaagagat 6900 agtaggtctc tggaatatgt taaaatgggc atgaggtaag cctacagagt cccttatgaa 6960 gtgggcatat gactcttgca gcttggctac cagctcggcg gtgatgagta catccagggc 7020 acagtagtcg agagtttcct ggatgatgtc ataacgcggt tggcttttct tttcccacag 7080 ctcgcggttg agaaggtatt cttcgtgatc cttccagtac tcttcgaggg gaaacccgtc 7140 tttttctgca cggtaagagc ccaacatgta gaactgattg actgccttgt agggacagca 7200 tcccttctcc actgggagag agtatgcttg ggctgcattg cgcagcgagg tatgagtgag 7260 ggcaaaagtg tccctgacca tgactttgag gaattgatac ttgaagtcga tgtcatcaca 7320 ggccccctgt tcccagagtt ggaagtccac ccgcttcttg taggcggggt tgggcaaagc 7380 gaaagtaaca tcattgaaga ggatcttgcc ggccctgggc atgaaatttc gggtgatttt 7440 gaaaggctga ggaacctctg ctcggttatt gataacctga gcggccaaga cgatctcatc 7500 aaagccattg atgttgtgcc ccactatgta cagttctaag aatcgagggg tgcccctgac 7560 atgaggcagc ttcttgagtt cttcaaaagt gagatctgta gggtcagtga gagcatagtg 7620 ttcgagggcc cattcgtgca cgtgagggtt cgctttaagg aaggaggacc agaggtccac 7680 tgccagtgct gtttgtaact ggtcccggta ctgacgaaaa tgctgtccga ctgccatctt 7740 ttctggggtg acgcaataga aggtttgggg gtcctgccgc cagcgatccc acttgagttt 7800 tatggcgagg tcataggcga tgttgacgag ccgctggtct ccagagagtt tcatgaccag 7860 catgaagggg attagctgct tgccaaagga ccccatccag gtgtaggttt ccacatcgta 7920 ggtgagaaag agcctttctg tgcgaggatg agagccaatc gggaagaact ggatctcctg 7980 ccaccagttg gaggaatggc tgttgatgtg atggaagtag aactccctgc gacgcgccga 8040 gcattcatgc ttgtgcttgt acagacggcc gcagtactcg cagcgattca cgggatgcac 8100 cttatgaatg agttgtacct gacttccttt gacgagaaat ttcagtggaa aattgaggcc 8160 tggcgcttgt acctcgcgct ttactatgtt gtctgcatcg gcatgaccat cttctgtctc 8220 gatggtggtc atgctgacga gccctcgcgg gaggcaagtc cagacctcgg cgcggcaggg 8280 gcggagctcg aggacgagag cgcgcaggcc ggagctgtcc agggtcctga gacgctgcgg 8340 agtcaggtta gtaggcagtg tcaggagatt aacttgcatg atcttttgga gggcgtgagg 8400 gaggttcaga tagtacttga tctcaacggg tccgttggtg gagatgtcga tggcttgcag 8460 ggttccgtgt cccttgggcg ctaccaccgt gcccttgttt ttcattttgg acggcggtgg 8520 ctctgttgct tcttgcatgt ttagaagcgg tgtcgagggc gcgcaccggg cggcaggggc 8580 ggctcgggac ccggcggcat ggctggcagt ggtacgtcgg cgccgcgcgc gggtaggttc 8640 tggtactgcg ccctgagaag actcgcatgc gcgacgacgc ggcggttgac atcctggatc 8700 tgacgcctct gggtgaaagc taccggcccc gtgagcttga acctgaaaga gagttcaaca 8760 gaatcaatct cggtatcgtt gacggcggct tgcctaagga tttcttgcac gtcgccagag 8820 ttgtcctggt aggcgatctc ggccatgaac tgctcgatct cttcctcttg aagatctccg 8880 cggcccgctc tctcgacggt ggccgcgagg tcgttggaga tgcgcccaat gagttgagag 8940 aatgcattca tgcccgcctc gttccagacg cggctgtaga ccacagcccc cacgggatct 9000 ctcgcgcgca tgaccacctg ggcgaggttg agctccacgt ggcgggtgaa gaccgcatag 9060 ttgcataggc gctggaaaag gtagttgagt gtggtggcga tgtgctcggt gacgaagaaa 9120 tacatgatcc atcgtctcag cggcatctcg ctgacatcgc ccagcgcttc caagcgctcc 9180 atggcctcgt agaagtccac ggcaaagtta aaaaactggg agttacgcgc ggacacggtc 9240 aactcctctt ccagaagacg gataagttcg gcgatggtgg tgcgcacctc gcgctcgaaa 9300 gcccctggga tttcttcctc aatctcttct tcttccacta acatctcttc ctcttcaggt 9360 ggggctgcag gaggaggggg aacgcggcga cgccggcggc gcacgggcag acggtcgatg 9420 aatctttcaa tgacctctcc gcggcggcgg cgcatggtct cggtgacggc acgaccgttc 9480 tccctgggtc tcagagtgaa gacgcctccg cgcatctccc tgaagtggtg actgggaggc 9540 tctccgttgg gcagggacac cgcgctgatt atgcatttta tcaattgccc cgtaggtact 9600 ccgcgcaagg acctgatcgt ctcaagatcc acgggatctg aaaacctttc gacgaaagcg 9660 tctaaccagt cgcaatcgca aggtaggctg agcactgttt cttgcgggcg ggggcggcta 9720 gacgctcggt cggggttctc tctttcttct ccttcctcct cttgggaggg tgagacgatg 9780 ctgctggtga tgaaattaaa ataggcagtt ttgagacggc ggatggtggc gaggagcacc 9840 aggtctttgg gtccggcttg ttggatacgc aggcgatgag ccattcccca agcattatcc 9900 tgacatctgg ccagatcttt atagtagtct tgcatgagtc gttccacggg cacttcttct 9960 tcgcccgctc tgccatgcat gcgagtgatc ccgaacccgc gcatgggctg gacaagtgcc 10020 aggtccgcta caaccctttc ggcgaggatg gcttgctgca cctgggtgag ggtggcttgg 10080 aagtcgtcaa agtccacgaa gcggtggtag gccccggtgt tgattgtgta ggagcagttg 10140 gccatgactg accagttgac tgtctggtgc ccagggcgca cgagctcggt gtacttgagg 10200 cgcgagtatg cgcgggtgtc aaagatgtaa tcgttgcagg tgcgcaccag gtactggtag 10260 ccaatgagaa agtgtggcgg tggctggcgg tacaggggcc atcgctctgt agccggggct 10320 ccgggggcga ggtcttccag catgaggcgg tggtagccgt agatgtacct ggacatccag 10380 gtgataccgg aggcggtggt ggatgcacgt gggaactcgc gcacgcggtt ccagatgttg 10440 cgcagcggca tgaagtagtt catggtaggc acggtctggc cagtgaggcg cgcgcagtca 10500 ttgacgctct gtagacacgg agaaaacgaa agcgatgagc ggctcgactc cgtggtctgg 10560 gggaacgtga acgggttggg tcgcggtgta ccccggttcg agtccaaagc taagcgatca 10620 cgctcggatc ggccggagcc gcggctaacg tggtattggc tatcccgtct cgacccagcc 10680 gacgaatatc cagggtacgg agtagagtcg tttttgctgc tttttcctgg acgtgtgcca 10740 ttgccacgtc aagctttaga acgctcagtt ctcgggccgt gagtggctcg cgcccgtagt 10800 ctggagaatc agtcgccagg gttgcgttgc ggtatgcccc ggttggagcc taagcgcggc 10860 tcgtatcggc cggtttccgc gacaagcgag ggtttggcag ccccgttatt tccaagaccc 10920 cgccagccga cttctccagt ttacgggagc gagccctttt tttttttttt ttgtttttgt 10980 cgcccagatg catccagtgc tgcgacagat gcgcccccag caacaggccc cttctcagca 11040 acagccacaa aaggctcttc ttgctcctgc aactactgca gctgcagccg tgagcggcgc 11100 gggacagccc gcctatgatc tggacttgga agagggcgag ggattggcgc gcctgggggc 11160 tccatcgccc gagcggcacc cgcgggtgca actaaaaaag gactctcgcg aggcgtacgt 11220 gccccagcag aacctgttca gggacaggag cggcgaggag ccagaggaga tgcgagcatc 11280 tcgatttaac gcgggtcgcg agctgcgcca cggtctggat cgaagacggg tgctgcaaga 11340 cgaggatttt gaggtcgatg aagtcacagg gatcagccca gctagggcac atgtggccgc 11400 ggccaaccta gtctcggcct acgagcagac cgtgaaggag gagcgcaact tccaaaaatc 11460 ttttaacaac catgtgcgca ccctgatcgc ccgcgaggaa gtgaccctgg gtctgatgca 11520 tctgtgggac ctgatggagg ctatcgccca aaaccccact agcaaaccac tgacagctca 11580 gctgtttctg gtggttcaac atagcaggga caacgaggca ttcagggagg cgttgttgaa 11640 catcaccgag cctgatggga gatggctgta tgatctgatc aacatcctgc aaagtattat 11700 agtgcaggaa cgtagcctgg gtttggctga gaaagtggca gctatcaact actcggtctt 11760 gagcctgggc aaatactacg ctcgcaagat ctacaagacc ccctacgtac ccatagacaa 11820 ggaggtgaag atagatgggt tttacatgcg catgactctg aaggtgctga ctctgagcga 11880 cgatctgggg gtgtatcgca atgacaggat gcaccgcgcg gtgagcgcca gcaggaggcg 11940 cgagctgagc gacagagaac ttatgcacag cttgcaaaga gctctaacgg gggccgggac 12000 tgatggggag aactactttg acatgggagc ggatttgcaa tggcaaccca gtcgcagggc 12060 catggaggct gcagggtgtg agcttcctta catagaagag gtggatgaag tcgaggacga 12120 ggagggcgag tacttggaag actgatggcg cgacccgtat ttttgctaga tggaacagca 12180 gcaggcaccg gaccccgcaa tgcgggcggc gctgcagagc cagccgtccg gcattaactc 12240 ctcggacgat tggacccagg ccatgcaacg cataatggcg ctgacgaccc gcaaccccga 12300 agcctttaga cagcaacccc aggccaaccg cctttctgcc atactggagg ccgtagtgcc 12360 ctcccgctcc aaccccaccc acgagaaggt cctggctatc gtgaacgcgc tggtggagaa 12420 caaggccatc cgtcccgatg aggccgggct ggtatacaat gctctcttgg agcgcgtggc 12480 ccgttacaac agcagcaacg tgcaaaccaa cctggaccgg atggtgaccg atgtgcgcga 12540 ggccgtgtct cagcgcgagc gattccagcg cgacgccaac ttggggtcgt tggtagcgct 12600 aaacgctttc ctcagcaccc agcccgccaa cgtgccccgt ggtcagcaag actatacaaa 12660 ctttttgagt gcattgagac tcatggtagc tgaggtgccc cagagcgagg tgtaccagtc 12720 cgggccagat tacttcttcc agaccagcag acagggcttg cagacagtga acctgactca 12780 ggctttcaag aacctgaagg gtctgtgggg agtgcacgcc ccagtagggg atcgcgcgac 12840 cgtgtctagc ttgctgactc ccaactcccg cctgctgctg ctgctggtat ccccctttac 12900 tgacagcggt agcattgacc gcaactcgta cttgggctac ctgcttaacc tgtatcgcga 12960 ggccatagga cagagccagg tggacgagca gacctatcaa gaaatcaccc aagtgagccg 13020 cgccctgggt caggaagaca cgggcagttt ggaagccacc ctgaacttct tgctaaccaa 13080 ccggtcacag aagatccctc ctcagtatgc gcttaccgct gaggaggagc ggatcctcag 13140 atacgtgcaa cagagcgttg gactgttcct gatgcaggag ggggcgacac ctaccgccgc 13200 gctggacatg acagctcgaa acatggagcc cagcatgtat gctagtaaca ggcctttcat 13260 taacaaactg ctggactacc tgcacagggc ggccgccatg aactctgatt atttcaccaa 13320 tgctatcctg aacccacact ggctgccccc acctggtttc tacactggcg agtacgacat 13380 gcccgacccc aatgacgggt tcctgtggga cgatgtggac agcagcatat tttccccgcc 13440 tcccggttat acagtttgga agaaggaagg gggcgataga agacactctt ccgtgtcgct 13500 atccggaacg gctggtgctg ccgcgaccgt gcccgaagct gcaagtcctt tccctagctt 13560 gcccttttca ctaaacagcg ttcgcagcag tgaactgggg agaataaccc gcccgcgctt 13620 gatgggcgag gatgagtact tgaatgactc tttgctgagg ccagagaggg aaaagaactt 13680 ccccaacaat ggaatagaga gtctggtgga taagatgagt agatggaaga cctatgcgca 13740 ggatcacaga gacgagccca ggatcttggg ggctacaagc agaccgatcc gtagacgcca 13800 gcgccacgac aggcagatgg gtcttgtgtg ggacgatgag gactctgccg atgatagcag 13860 cgtgttggac ttgggtggaa gaggaggggg caacccgttc gctcatctgc gtcccagatt 13920 cgggcgcatg ttgtaaaagt gaaagtaaaa taaaaaggca actcaccaag gccatggcga 13980 ccgagcgtgc gttcgttctt ttttgttatc tgtgtctagt acgatgagga gacgagccgt 14040 gctaggcgga gcggtggtgt atccggaggg tcctcctcct tcttacgaga gcgtgatgca 14100 gcaacaggcg gcgatgatac agcccccact ggaggctccc ttcgtacccc cacggtacct 14160 ggcgcctacg gaagggagaa acagcattcg ttactcggag ctgtcgcccc tgtacgatac 14220 caccaagttg tatctggtgg acaacaagtc ggcggacatc gcctccctga actatcagaa 14280 cgaccacagc aacttcctga ccacggtggt gcagaacaat gactttaccc ccacggaggc 14340 tagcacccag accatcaact ttgacgagcg gtcgcgatgg ggcggtcagc tgaagaccat 14400 catgcacacc aacatgccca acgtgaacga gtacatgttc agcaacaagt tcaaggcgag 14460 ggtgatggtg tccagaaaag ctcctgaagg tgttacagta aatgacacct atgatcataa 14520 agaggatatc ttgaagtatg agtggtttga gttcatttta ccagaaggca acttttcagc 14580 caccatgacg atcgacctga tgaacaatgc catcattgac aactacctgg aaattggcag 14640 acagaatgga gtgctggaaa gtgacattgg tgttaagttt gacactagaa atttcaggct 14700 cgggtgggac cccgaaacta agttgattat gccaggtgtc tacacttatg aggcattcca 14760 tcctgacatt gtattgctgc ctggttgcgg ggtagacttt actgaaagcc gacttagcaa 14820 cttgcttggc atcaggaaga gacatccatt ccaggagggt ttcaaaatca tgtatgaaga 14880 tcttgaaggg ggtaatattc ctgccctttt ggatgtcact gcctatgagg aaagcaaaaa 14940 ggataccact actgaaacaa ccacactggc tgttgcagag gaaactagtg aagatgatga 15000 tataactaga ggagatacct atataactga aaaacaaaaa cgtgaagctg cagctgctga 15060 agttaaaaaa gagttaaaga tccaacctct agaaaaagac agcaagagta gaagctacaa 15120 tgtcttggaa gacaaaatca acacagccta ccgcagttgg tacctgtcct acaattacgg 15180 taaccctgag aaaggaataa ggtcttggac actgctcacc acttcagatg tcacctgtgg 15240 ggcagagcag gtctactggt cgctccctga catgatgcaa gacccagtca ccttccgctc 15300 cacaagacaa gtcaacaact acccagtggt gggtgcagag cttatgcccg tcttctcaaa 15360 gagtttctac aatgagcaag ccgtgtactc tcagcagctc cgacaggcca cttcgctcac 15420 gcacgtcttc aaccgcttcc ctgagaacca gatcctcatc cgcccgccgg cgcccacaat 15480 taccaccgtc agtgaaaacg ttcctgctct cacagatcac gggaccctgc cgttacgcag 15540 cagtatccgg ggagtccagc gcgtgaccgt tactgacgcc agacgccgca cctgtcccta 15600 cgtttacaag gccctgggca tagtcgcgcc gcgcgttctt tcaagccgca ctttctaaaa 15660 aaaaaaaaaa tgtccattct catctcgccc agtaataata ccggttgggg actgtatgcg 15720 cccaccaaga tgtatggagg cgcccgcaag cgctctaccc agcatcctgt gcgcgttcgc 15780 ggtcatttcc gcgctccctg gggcgcactc aagggtcgta cccgcactcg gaccacggtc 15840 gatgatgtga tcgaccaggt ggtcgccgat gctcgtaatt atactcctac tgcgcctaca 15900 tctactgtgg atgcagttat tgacagtgtg gtggcagacg cccgcgccta tgctcgccgg 15960 aagagccgaa ggaggcgcat cgccaggcgc cacagggcta ctcccgccat gcgagccgca 16020 aaagctattc tgcggagggc caaacgtgtg gggcgaagag ccatgcttag agcggccaga 16080 cgcgcggctt caggtgccag cagcggcagg tcccgcaggc gcgcggccac ggcggcagca 16140 gcggccattg ccaacatggc ccaaccgcga agaggcaatg tgtactgggt gcgtgatgcc 16200 actaccggcc agcgcgtgcc cgtgcgcacc cgcccccctc gcacttagaa gatactgagc 16260 agtctccgat gttgtgtccc agcggcaagt atgtccaagc gcaaatacaa ggaagagatg 16320 ctccaggtca tcgcgcctga aatctacggt ccgccggtga aggatgaaaa aaagccccgc 16380 aaaatcaagc gggtcaaaaa taacaaaaag gaagaagatg acgatgatgg gctggtggag 16440 tttgtgcgcg agttcgcccc aagacggcgc gtgcagtggc gcgggcgcaa agtgcgtcaa 16500 gtgctcagac ccgggaccac tgtggttttt acacctggcg agcgttccag cactactttt 16560 aaacggtcct atgatgaggt gtacggggat gacgatattc ttgagcaggc ggcagaccgc 16620 cttgacgagt ttgcttatgg caagcgcact agatccagtc ccaaagagga ggctgtgtcc 16680 attcctttgg atcatggaaa tcccaccccc agcctcaaac cagtcaccct gcagcaagtg 16740 ctgcccgtgc ctgcgcggag aggcgtaaag cgcgagggtg aggacctata tcccaccatg 16800 cagctaatgg tgcccaagcg ccagaggcta gaagacgtac tggagaaaat gaaagtggat 16860 gccgatatcc agcctgaggt caaagtaaga cctatcaagg aagtggcgcc aggtttggga 16920 gtacaaacct tcgacatcaa gattcccacc gagtccatgg aagtgcagac cgaacctgca 16980 aaacccacca cctcaattga ggtgcaaacg gaaccctgga tgcccgcgcc cgttgccgcc 17040 cccagcacca ctcgaagatc acgacgaaag tacggcccag caagtctgct aatgcccaac 17100 tatgctctgc acccatccat cattcccact ccgggttaca gaggcactcg ctactatcga 17160 aaccggagca acacctctcg ccgccgcaaa ccacctgcaa gtcgcactcg ccgtcgccgc 17220 cgccgcaaca ctgccagcaa attgactccc gccgccctgg tgcggagagt gtaccgcgat 17280 ggtcgcgctg aacctctgac gctgccgcgc gcgcgctacc atccaagcat caccacttaa 17340 tgactgttga cgctgcctcc ttgcagatat ggccctcact tgccgccttc gcgtccccat 17400 tactggctac cgaggaagaa actcgcgccg tagaaggatg ttggggcgag ggatgcgccg 17460 ccacagacga aggcgcgcta tcagcagacg attagggggt ggctttttgc cagctcttat 17520 acccatcatc gccgcagcga tcggggcgat accaggcata gcttcagtgg cggttcaggc 17580 ctcgcagcgc cactaacatt ggaaaaaact tataaataaa aaatagaatg gactctgacg 17640 ctcctggtcc tgtgactatg tttttgtaga gatggaagac atcaattttt catccctggc 17700 tccgcgacac ggcacgaggc cgtacatggg cacctggagc gacatcggca cgagccaact 17760 gaacgggggc gccttcaatt ggagcagtat ctggagcggg cttaaaaatt ttggctcgac 17820 cgtaaaaacc tatgggaaca aagcttggaa cagcagcaca gggcaggctc tgagaaataa 17880 gcttaaggaa caaaacttcc aacagaaggt ggtcgatggg atcgcctctg gtattaacgg 17940 cgtagtggat ctggccaacc aggctgtaca aaaacagata aacagccgcc tggacccgcc 18000 gcccgcaacc cctggtgaaa tggaagtgga ggaagaactt cctccgctgg aaaagcgggg 18060 cgacaagcgt ccgcgacccg agctagagca gacgctggtg acgcgcgcag acgagccccc 18120 ttcatatgag gaggcagtaa agctcggaat gcccactacc aggcctgtag ctcacatggc 18180 taccggggtg atgaaacctt ctcagtcaca tcgacccgcc accttggact tgcctcctcc 18240 ccctgcttct gcggcgcctg ttcccaaacc tgtcgctacc agaaagccca ccgccgtaca 18300 gcccgtcgcc gtagccagac cgcgtcctgg gggcacaccg cgcccgaaag caaactggca 18360 aagtactctg aacagcatcg tgggtctggg cgtgcagagt gtaaagcgcc gtcgctgcta 18420 ttaattaaat atggagtagc gcttaacttg cttgtctgtg tgtatgtatc atcaccacgc 18480 cgccgcagca gaggagaaag gaagaggtcg cgcgccgagg ctgagttgct ttcaagatgg 18540 ccaccccatc gatgatgccc caatgggcat acatgcacat cgccggacag gatgcttcgg 18600 agtacctcag tccgggtctg gtgcagttcg cccgtgcaac agacacctac ttcagtatgg 18660 ggaacaaatt tagaaacccc acagtggcgc ccacccacga tgtgaccacc gaccgtagcc 18720 agcgcctgat gctgcgcttc gtgcccgttg accgggaaga caatacctac tcttacaaag 18780 ttcgctacac gctggctgta ggcgacaaca gagtgcttga catggccagc acattctttg 18840 acattcgggg ggtgcttgat agaggtccta gcttcaagcc atattccggc acagcttaca 18900 attcactcgc tcctaagggc gcgcccaata catctcagtg gatagttaca acaaatgggg 18960 acaatgcagt aactaccacc acaaacacat ttggcattgc ttccatgaag ggagacaata 19020 ttactaaaga aggtttgcaa attgggaaag acattaccac tactgaagga gaagaaaagc 19080 ccatttatgc cgataaaaca tatcagccag agcctcaagt tggagaagaa tcatggactg 19140 atactgatgg aacaaatgaa aagtttggtg gaagagccct taaaccagct accaacatga 19200 agccatgcta cgggtctttt gcaagaccta caaacataaa agggggccaa gctaaaaaca 19260 gaaaagtaaa accaacaacc gaaggagggg ttgaaactga ggaaccagat attgatatgg 19320 aatttttcga tggtagagat gctgttgcag gagctttagc gcctgaaatt gtgctttata 19380 cggaaaatgt aaatttggaa actccagaca gtcatgtggt atataaacca gaaacgtcta 19440 ataactctca tgcaaatttg ggtcaacaag ccatgcctaa cagacccaat tacattggct 19500 tcagggataa cttcgtaggc ctaatgtact acaacagtac tggaaatatg ggagttttgg 19560 ctggccaagc atcacaactg aatgcagtgg ttgacttgca ggacagaaat actgaactgt 19620 catatcagct tttgcttgat tctctgggag acagaaccag atacttcagc atgtggaatc 19680 aggctgtgga cagttacgat cccgatgttc gcattattga aaatcatggc atcgaggatg 19740 aactgcctaa ttactgtttt cctctgaatg gcataggacc agggcacaca tatcaaggca 19800 ttaaagttaa aaccgatgac actaatggat gggaaaaaga tgctaatgtt gctccagcta 19860 atgaaataac cataggcaac aacctggcta tggaaattaa tatccaagct aacctttgga 19920 gaagttttct gtactctaat gtggctttgt accttccaga tgtttacaag tacacgccac 19980 ctaacattac tttgcccact aacaccaaca cctatgagta catgaacggg cgagtggtat 20040 ccccatccct ggttgattca tacatcaaca ttggcgccag gtggtctctt gacccaatgg 20100 acaatgtgaa tccattcaac caccaccgca atgctggtct gcgctacagg tccatgcttc 20160 tgggaaatgg tcgttatgtg cctttccaca tacaagtgcc tcagaaattc tttgctgtca 20220 agaacctact tcttctacct ggctcctaca cctacgagtg gaacttccga aaggatgtga 20280 acatggtcct gcaaagttcc cttggaaatg acctcagaac ggatggtgct accataagtt 20340 tcaccagcat caatctctat gccaccttct tccccatggc tcacaacaca gcttccaccc 20400 ttgaagccat gctgcgcaac gataccaatg atcagtcatt taacgactac ctctctgcag 20460 ctaacatgct ttaccccatt cctgccaatg caaccaacat tccaatttcc atcccatctc 20520 gcaactgggc agccttcagg ggctggtcct tcaccagact caaaaccaag gagactccat 20580 ctcttggatc agggttcgat ccctacttcg tatattctgg atctattccc tacctggatg 20640 gcacctttta ccttaaccac actttcaaga aggtctccat catgtttgac tcctcagtca 20700 gctggcctgg caatgacagg ctgttgagtc caaatgagtt tgaaatcaag cgcactgtgg 20760 acggggaagg atacaacgtg gcacaatgca acatgaccaa agactggttc ctggttcaga 20820 tgcttgccaa ttacaacatt ggctaccagg gcttttacat ccctgaggga tacaaggatc 20880 gcatgtactc ctttttcaga aacttccagc ctatgagcag gcaggtggtt gatgaggtta 20940 attacactga ctacaaagcc gtcaccttac cataccaaca caacaactct ggctttgtag 21000 ggtaccttgc acctactatg agacaagggg aaccttaccc agccaattat ccatacccgc 21060 tcatcggaac tactgccgtt aagagtgtca cccagaaaaa gttcctgtgc gacaggacca 21120 tgtggcgcat tcccttctcc agcaacttca tgtccatggg ggcccttacc gacctgggac 21180 agaacatgct ctatgccaac tcagcccatg cgctggacat gacttttgag gtggatccca 21240 tggatgagcc caccctgctt tatcttcttt tcgaagtctt cgacgtggtc agagtgcacc 21300 agccacaccg cggcgtcatc gaggccgtct acctgcgcac accgttctcg gccggcaacg 21360 ccaccacata agaagcctct tgcttcttgc aagcagcagc tgcagccatg acatgcgggt 21420 ccggaaacgg ctccagcgag caagagctca aagccatcgt ccgagacctg ggctgcggac 21480 cctatttcct gggaaccttt gacaagcgtt tcccggggtt catggccccc gacaagctcg 21540 cctgcgccat agtcaacact gccggacgcg agacgggggg agagcactgg ctggcttttg 21600 gttggaaccc gcgctacaac acctgctacc tttttgatcc ttttgggttc tcggatgagc 21660 ggctcaaaca gatttaccag tttgagtacg aggggctcct gcgtcgcagt gcccttgcta 21720 ccaaagaccg ctgcatcacc ctggagaagt ctacccaaag cgtgcagggt ccgcgctcag 21780 ccgcctgtgg acttttttgc tgtatgttcc ttcatgcctt tgtgcactgg cccgaccgcc 21840 ccatggacgg aaaccccacc atgaagttgc tgactggggt gtccaacagc atgctccaat 21900 caccccaagt ccagcccacc ctgcgccgca accaggaggt gctataccgc ttcctaaaca 21960 cccactcatc ttactttcgt tctcaccgcg cgcgcattga aagggccacc gcgtttgacc 22020 gtatggatat gcaataagtc atgtaaaacc gtgttcaata aacagcactt tatttttaca 22080 tgcactgagg ctctggtttt gctcatttgt ttcatcattt actcagaagt cgaatgggtt 22140 ctggcgggag tcagagtgac ccgcgggcag ggatacgttg cggaactgta acctgttctg 22200 ccacttgaac tcggggatta ccagcttggg aactggaatc tcgggaaagg tgtcttgcca 22260 caactttctg gtcagttgca tagcgccaag caggtcagga gcagagatct tgaaatcaca 22320 gttggggccg gcattctgga cacgggagtt gcgatacact gggttgcaac actggaacac 22380 tatcaacgct gggtgtctta cgcttgccaa cacggttggg tcactgatgg tagtcacatc 22440 caagtcttca gcattggcca tcccaaaggg ggtcatctta catgtctgcc tgcccatcac 22500 gggagcgcag cctggcttgt ggttgcaatc acaatgaatg gggatcagca tcatcctggc 22560 ttggtcggga gttatccctg ggtacacagc cttcatgaag gcttcgtact gcttaaaagc 22620 ttcctgggcc ttacttccct cggtgtagaa catcccacag gacttgctgg aaaattgatt 22680 agtagtacag ttggcatcat tcacacaaca gcgggcatcg ttgttggcca actgaaccac 22740 atttctgccc cagcggtttt gggtgatctt ggctctgtct ggattctcct tcatagcgcg 22800 ctgcccgttc tcgctcgcca catccatctc gataatgtgg tccttctgga tcatgatagt 22860 gccatgcagg catttcacct tgccttcata atcggtgcat ccatgagccc acagagcgca 22920 cccggtgcac tcccaattat tgtgggcgat ctcagaataa taatgtacca atccctgcat 22980 gaatcttccc atcattgttg tcaaggtctt catgctggta aatgtcagcg ggatgccacg 23040 gtgctcctcg ttcacatact ggtggcagat acgcttgtat tgctcgtgct gctctggcat 23100 cagcttgaaa gaggttctca gatcattatc cagcctgtac ctttccatta gcacagccat 23160 cacttccatg cccttctccc aggcagatac caggggcaga ctcaaaggat tcctaacagc 23220 aataaaagta gctcctttag ctatagggtc attcttgtcg atcttctcaa cacttctctt 23280 gccatccttc tcaatgatgc gcaccggggg gtagctgaag cccacggcca ccaactgagc 23340 ctgttctctt tcttcttcac tatcctggct gatgtcttgc agagggacat gcttggtctt 23400 cctgggcttc ttcttgggag ggatcggggg aggactgttg ctccgctccg gagacaggga 23460 tgactgcgaa gtttcgctta ccaataccac ctggctctcg gtagaagaac cggaccccac 23520 acgacggtag gtgttcctct tcgggggcag aggtggaggc gactgagatg ggctgcggtc 23580 tggccttgga ggcggatggc tggcagagct cattccgcgt tcgggggtgt gctcccggtg 23640 gcggtcgctt gactgatttc ctccgcggct ggccattgtg ttctcctagg cagagaaaca 23700 acagacatgg aaactcagcc atcactgcca acatcgctgc aagcaccatc acacctcgcc 23760 cccagcagcg acgaggagga gagcttaacc accccaccac ccagtcccgc taccaccacc 23820 tctaccctcg atgatgagga ggaggtcgac gcagcccagg agatgcaggc gcaggataat 23880 gtgaaaacgg aagagattga ggcagatgtc gagcaggacc cgggctatgt gacgccggcg 23940 gagcaccagg aggagctgaa acgctttcta gacagagagg atgacgaccg cccagagcat 24000 caagcagatg gcgtttacca ggaggctggg atcagggatc atgtcgccga ctacctcacc 24060 ggccttggtg gggaggacgt gctcctcaaa catctagcaa ggcagtcgat catagttaaa 24120 gacgcattgc tcgatctcac tgaagtgccc atcagtgtgg aagagcttag ccgcgcctac 24180 gagctgaacc tcttttcgcc tcaggtaccc cccaagcggc agccaaacgg cacctgcgag 24240 gccaaccctc gactcaactt ctatccagct tttactatcc ccgaagtgtt ggccacctac 24300 cacatctttt tcaagaacca aaagattcca gtctcctgcc gcgccaaccg cacccgcgcc 24360 gatgccctgc tcaacttggg tccgggagct cgcttacctg atatagcttc cttggaagag 24420 gttccaaaga tctttgaggg tctgggaagt gatgagacac gggccgcaaa tgctctgcaa 24480 cagggagaga atgacatgga tgaacaccac agcgctctgg tggaactgga gggtgacaat 24540 gcccggattg cagtgctcaa gcgcagtatc gtggtcaccc attttgccta ccccgctgtt 24600 aacctgcccc ccaaagttat gagcgctgtc atggaccatc tgctcatcaa acgagcaaga 24660 cctctttcag aaaaccagaa catgcaggat ccagacgcct cggacgaggg caagccggta 24720 gtcagtgacg agcagctatc tcgctggctg ggtaccaact ccccccgaga tttggaagag 24780 aggcgcaagc ttatgatggc tgtagtgcta gtaactgtgg agctggagtg tctgcgccgc 24840 tttttcaccg accctgagac cctgcgcaag ctagaggaga acctgcacta cacctttaga 24900 catggcttcg tgcggcaggc atgcaagatc tccaacgtgg agcttaccaa cctggtttct 24960 tacatgggca ttttgcatga gaaccgacta gggcagagcg tcctgcacac cacccttaaa 25020 ggggaggccc gccgtgacta catccgagac tgtgtctacc tctacctctg ccatacctgg 25080 caaactggta tgggtgtgtg gcaacagtgt ttggaagagc agaacctaaa agagctggac 25140 aagctcttgc agagatccct caaagccctg tggacaggtt ttgatgagcg caccgtcgcc 25200 tcggacctgg cagacatcat cttccccgag cgtctcaggg ttactctgcg aaacggcctg 25260 ccagacttta tgagccagag catgcttaac aactttcgct ctttcatcct ggaacgctcc 25320 ggtatcctgc ctgccacctg ctgtgcgctg ccctccgact ttgtgcctct cacctaccgc 25380 gagtgcccac cgccgctatg gagccactgc tacctgttcc gcctggccaa ctacctctcc 25440 taccactcgg atgttataga ggatgtgagc ggagacggcc tgctggaatg ccactgccgc 25500 tgcaatcttt gcacacccca ccgctccctt gcctgcaacc cccagttgct gagcgagacc 25560 cagattatcg gcaccttcga gctgcagggt cccagaagta aaggcgaggg gtcttctccg 25620 gggcagagtt tgaaactgac accggggctg tggacctccg cctacctgcg caagtttcac 25680 cccgaggact accatcccta tgagatcagg ttctatgagg accaatcaca tcctcccaaa 25740 gtcgagctct cagcctgcgt catcacccag ggagcaattc tggcccaatt gcaagccatc 25800 caaaaatctc gccaagaatt tctgctaaaa aagggaaacg gggtctacct tgaccctcag 25860 accggtgagg agctcaacac aaggttcccc caggatgtcc catcgccgag gaagcaagaa 25920 gttgaaggtg cagctgtcgc ccccagagga tatgaaggaa gactgggaca gtcaggcaga 25980 ggaggagatg gaagattggg acagccaggc agaggaggtg gacagcctgg aggaagacag 26040 tttggaggag gaagacgagg aggcagagga ggtggaagaa gcaaccgccg ccaaacagtt 26100 gtcatcggcg gcggagacaa gcaagtcccc agacagcagc acggctacca tctccgctcc 26160 gggtcggggg gcccagcggc ggcccaacag tagatgggac gagaccgggc gattcccaaa 26220 cccgaccacc gcttccaaga ccggtaagaa ggagcgacag ggatacaagt cctggcgtgg 26280 acataaaaac gctatcatct cctgcttgca tgaatgcggg ggcaacatat ccttcacccg 26340 gcgatacctg ctcttccacc acggtgtaaa cttcccccgc aatatcttgc attactaccg 26400 tcacctccac agcccctact gcagtcagca agtcccggca accccgacag aaaaatacag 26460 cagcgacaac ggtgaccaga aaaccagcag ttagaaaatc cacaacaagt gcaccaggag 26520 gaggactgag gatcacagcg aacgagccag cgcagaccag agagctgagg aaccggatct 26580 ttccaaccct ctatgccatt ttccagcaga gtcgggggca agagcaggaa ctgaaagtaa 26640 aaaaccgatc tctgcgctcg ctcaccagaa gttgtttgta tcacaagagc gaagaccaac 26700 ttcagcgcac tctcgaggac gccgaggctc tcttcaacaa gtactgcgcg ctgactctta 26760 aagagtagcc cttgcccgcg ctcattttga aaacggcggg aatcacgtca cccttggcac 26820 ctgtcctttg cccttgtcat gagtaaagag attcccacgc cttacatgtg gagctatcag 26880 ccccaaatgg ggttggcagc aggcgcttcc caggactact ccacccgcat gaattggctt 26940 agcgccgggc cctcaatgat atcacgggtt aatgatatac gagcttatcg aaaccagtta 27000 ctcctagaac agtcagctct caccaccaca ccccgtcaac accttaatcc ccgaaattgg 27060 cccgccaccc tggtgtacca ggaaaatccc gctcccacca ccgtactact tcctcgagac 27120 gcccaggccg aagttcagat gactaacgca ggtgtacagc tggcgggcgg ttccgcccta 27180 tgtcgtcacc gacctcaaca gagtataaaa cgcctggtga ttagaggccg aggtatccag 27240 ctcaacgacg agtcggttag ctcttcgctt ggtctgcgac cagacggagt cttccaaatc 27300 gccggctgtg ggagatcttc cttcactcct cgtcaggctg tgctgacttt ggagagttcg 27360 tcctcgcagc cccgctcggg cggcattgga actctccagt ttgtggagga gtttactccc 27420 tctgtctact tcaacccctt ctccggctct cctggccagt acccggacga gttcatacca 27480 aacttcgacg caatcagcga gtcagtggat ggctatgatt gagtttatgt taagtggaga 27540 ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc cgccacaagt gctttgcccg 27600 cgactccggt gagttttgct actttgaatt gcccgaggat catatcgagg gcccggcgca 27660 cggcgtccgg cttaccgccc agggagagct tgcccgtagc ctgattcggg agtttaccca 27720 gcgccccctg ctagttgagc gggacagggg accctgtgtt ctcactgtga tttgcaactg 27780 tcctaaccct ggattacatc aagatctttg ttgccatctc tgtgctgagt ataataaata 27840 cagaaattaa aatatactgg ggctcctatc gccatcctgt aaacgccacc gtcttcaccc 27900 gcccaagcaa accaaggcga accttacctg gtacttttaa catctctccc tctgtgattt 27960 acaacagttt caacccagac ggagtgagtc tacgagagaa cctctccgag ctcagctact 28020 ccatcagaaa aaacaccacc ctccttacct gccgggaacg tacgagtgcg tcaccggccg 28080 ctgcaccaca cctaccgcct gaccgtaaac cagacttttt ccggacagac ctcaataact 28140 ctgtttacca gaacaggagg tgagcttaga aaacccttag ggtattaggc caaaggcgca 28200 gctactgtgg ggtttatgaa caattcaagc aactctacgg gctattctaa ttcaggtttc 28260 tctagaatcg gggttggggt tattctctgt cttgtgattc tctttattct tatactaacg 28320 cttctctgcc taaggctcgc cgcctgctgt gtgcacattt gcatttattg tcagcttttt 28380 aaacgctggg gtcgccaccc aagatgatta ggtacataat cctaggttta ctcacccttg 28440 cgtcagccca cggtaccacc caaaaggtgg attttaagga gccagcctgt aatgttacat 28500 tcgcagctga agctaatgag tgcaccactc ttataaaatg caccacagaa catgaaaagc 28560 tgcttattcg ccacaaaaac aaaattggca agtatgctgt ttatgctatt tggcagccag 28620 gtgacactac agagtataat gttacagttt tccagggtaa aagtcataaa acttttatgt 28680 atacttttcc attttatgaa atgtgcgaca ttaccatgta catgagcaaa cagtataagt 28740 tgtggccccc acaaaattgt gtggaaaaca ctggcacttt ctgctgcact gctatgctaa 28800 ttacagtgct cgctttggtc tgtaccctac tctatattaa atacaaaagc agacgcagct 28860 ttattgagga aaagaaaatg ccttaattta ctaagttaca aagctaatgt caccactaac 28920 tgctttactc gctgcttgca aaacaaattc aaaaagttag cattataatt agaataggat 28980 ttaaaccccc cggtcatttc ctgctcaata ccattcccct gaacaattga ctctatgtgg 29040 gatatgctcc agcgctacaa ccttgaagtc aggcttcctg gatgtcagca tctgactttg 29100 gccagcacct gtcccgcgga tttgttccag tccaactaca gcgacccacc ctaacagaga 29160 tgaccaacac aaccaacgcg gccgccgcta ccggacttac atctaccaca aatacacccc 29220 aagtttctgc ctttgtcaat aactgggata acttgggcat gtggtggttc tccatagcgc 29280 ttatgtttgt atgccttatt attatgtggc tcatctgctg cctaaagcgc aaacgcgccc 29340 gaccacccat ctatagtccc atcattgtgc tacacccaaa caatgatgga atccatagat 29400 tggacggact gaaacacatg ttcttttctc ttacagtatg attaaatgag acatgattcc 29460 tcgagttttt atattactga cccttgttgc gcttttttgt gcgtgctcca cattggctgc 29520 ggtttctcac atcgaagtag actgcattcc agccttcaca gtctatttgc tttacggatt 29580 tgtcaccctc acgctcatct gcagcctcat cactgtggtc atcgccttta tccagtgcat 29640 tgactgggtc tgtgtgcgct ttgcatatct cagacaccat ccccagtaca gggacaggac 29700 tatagctgag cttcttagaa ttctttaatt atgaaattta ctgtgacttt tctgctgatt 29760 atttgcaccc tatctgcgtt ttgttccccg acctccaagc ctcaaagaca tatatcatgc 29820 agattcactc gtatatggaa tattccaagt tgctacaatg aaaaaagcga tctttccgaa 29880 gcctggttat atgcaatcat ctctgttatg gtgttctgca gtaccatctt agccctagct 29940 atatatccct accttgacat tggctggaac gcaatagatg ccatgaacca cccaactttc 30000 cccgcgcccg ctatgcttcc actgcaacaa gttgttgccg gcggctttgt cccagccaat 30060 cagcctcgcc caccttctcc cacccccact gaaatcagct actttaatct aacaggagga 30120 gatgactgac accctagatc tagaaatgga cggaattatt acagagcagc gcctgctaga 30180 aagacgcagg gcagcggccg agcaacagcg catgaatcaa gagctccaag acatggttaa 30240 cttgcaccag tgcaaaaggg gtatcttttg tctggtaaag caggccaaag tcacctacga 30300 cagtaatacc accggacacc gccttagcta caagttgcca accaagcgtc agaaattggt 30360 ggtcatggtg ggagaaaagc ccattaccat aactcagcac tcggtagaaa ccgaaggctg 30420 cattcactca ccttgtcaag gacctgagga tctctgcacc cttattaaga ccctgtgcgg 30480 tctcaaagat cttattccct ttaactaata aaaaaaaata ataaagctta gacacttact 30540 tgaaatcagc aatacagtct ttgtcaaaac tttctaccag cagcacctca ccctcttccc 30600 aactctggta ctctaaacgt cggagggtgg catactttct ccacactttg aaagggatgt 30660 caaattttat ttcctcttct ttgcccacaa tcttcatttc tttatcccca gatggccaag 30720 cgagctcggc taagcacttc cttcaacccg gtgtaccctt atgaagatga aagcagctca 30780 caacacccat ttataaatcc tggtttcatt tcccctgacg ggttcacaca aagtccaaac 30840 ggggttttaa gtcttaaatg tgttaatcca cttaccactg caagcggctc cctccaactt 30900 aaagtgggaa gtggtcttac agtagacact actgatggat ccttagaaga aaacatcaaa 30960 gttaacaccc ccctaacaaa gtcaaaccat tctataaatt taccaatagg aaacggtttg 31020 caaatagaac aaaacaaact ttgcagtaaa ctcggaaatg gtcttacatt tgactcttcc 31080 aattctattg cactgaaaaa taacacttta tggacaggtc caaaaccaga agccaactgc 31140 ataattgaat acgggaaaca aaacccagat agcaaactaa ctttaatcct tgtaaaaaat 31200 ggaggaattg ttaatggata tgtaacgcta atgggagcct cagactacgt taacacctta 31260 tttaaaaaca aaaatgtctc cattaatgta gaactatact ttgatgccac tggtcatata 31320 ttaccagact catcttctct taaaacagat ctagaactaa aatacaagca aaccgctgac 31380 tttagtgcaa gaggttttat gccaagtact acagcgtatc catttgtcct tcctaatgcg 31440 ggaacacata atgaaaatta tatttttggt caatgctact acaaagcaag cgatggtgcc 31500 ctttttccgt tggaagttac tgttatgctt aataaacgcc tgccagatag tcgcacatcc 31560 tatgttatga cttttttatg gtccttgaat gctggtctag ctccagaaac tactcaggca 31620 accctcataa cctccccatt taccttttcc tatattagag aagatgacta ataaagaatc 31680 gtttgtgtta tgtttcaacg tgtttatttt tcaattgcag aaaatttcga atcatttttc 31740 attcagtagt atagccccac caccacatag cttatacaga tcaccgtacc ttaatcaaac 31800 ctacatgggg gtagagtcat aatcgtgcat caggataggg cggtggtgct gcagcagcgc 31860 gcgaataaac tgctgccgcc gccgctccgt cctgcaggaa tacaacatgg cagtggtctc 31920 ctcagcgatg attcgcaccg cccgcagcat aaggcgcctt gtcctccggg cacagcagcg 31980 caccctgatc tcacttaaat cagcacagta actgcagcac agcaccacaa tattgttcaa 32040 aatcccacag tgcaaggcgc tgtatccaaa gctcatggcg gggaccacag aacccacgtg 32100 gccatcatac cacaagcgca ggtagattaa gtggcgaccc ctcataaaca cgctggacat 32160 aaacattacc tcttttggca tgttgtaatt caccacctcc cggtaccata taaacctctg 32220 attaaacatg gcgccatcca ccaccatcct aaaccagctg gccaaaacct gcccgccggc 32280 tatacactgc agggaaccgg gactggaaca atgacagtgg agagcccagg actcgtaacc 32340 atggatcatc atgctcgtca tgatatcaat gttggcacaa cacaggcaca cgtgcataca 32400 cttcctcagg attacaagct cctcccgcgt tagaaccata tcccagggaa caacccattc 32460 ctgaatcagc gtaaatccca cactgcaggg aagacctcgc acgtaactca cgttgtgcat 32520 tgtcaaagtg ttacattcgg gcagcagcgg atgatcctcc agtatggtag cgcgggtttc 32580 tgtctcaaaa ggaggtagac gatccctact gtacggagtg cgccgagaca accgagatcg 32640 tgttggtcgt agtgtcatgc caaatggaac gccggacgta gtcatatttc ctgaagcaaa 32700 accaggtgcg ggcgtgacaa acagatctgc gtctccggtc tcgccgctta gatcgctctg 32760 tgtagtagtt gtagtatatc cactctctca aagcatccag gcgccccctg gcttcgggtt 32820 ctatgtaaac tccttcatgc gccgctgccc tgataacatc caccaccgca gaataagcca 32880 cacccagcca acctacacat tcgttctgcg agtcacacac gggaggagcg ggaagagctg 32940 gaagaaccat gttttttttt ttattccaaa agattatcca aaacctcaaa atgaagatct 33000 attaagtgaa cgcgctcccc tccggtggcg tggtcaaact ctacagccaa agaacagata 33060 atggcatttg taagatgttg cacaatggct tccaaaaggc aaacggccct cacgtccaag 33120 tggacgtaaa ggctaaaccc ttcagggtga atctcctcta taaacattcc agcaccttca 33180 accatgccca aataattctc atctcgccac cttctcaata tatctctaag caaatcccga 33240 atattaagtc cggccattgt aaaaatctgc tccagagcgc cctccacctt cagcctcaag 33300 cagcgaatca tgattgcaaa aattcaggtt cctcacagac ctgtataaga ttcaaaagcg 33360 gaacattaac aaaaataccg cgatcccgta ggtcccttcg cagggccagc tgaacataat 33420 cgtgcaggtc tgcacggacc agcgcggcca cttccccgcc aggaaccatg acaaaagaac 33480 ccacactgat tatgacacgc atactcggag ctatgctaac cagcgtagcc ccgatgtaag 33540 cttgttgcat gggcggcgat ataaaatgca aggtgctgct caaaaaatca ggcaaagcct 33600 cgcgcaaaaa agaaagcaca tcgtagtcat gctcatgcag ataaaggcag gtaagctccg 33660 gaaccaccac agaaaaagac accatttttc tctcaaacat gtctgcgggt ttctgcataa 33720 acacaaaata aaataacaaa aaaacattta aacattagaa gcctgtctta caacaggaaa 33780 aacaaccctt ataagcataa gacggactac ggccatgccg gcgtgaccgt aaaaaaactg 33840 gtcaccgtga ttaaaaagca ccaccgacag ctcctcggtc atgtccggag tcataatgta 33900 agactcggta aacacatcag gttgattcac atcggtcagt gctaaaaagc gaccgaaata 33960 gcccggggga atacataccc gcaggcgtag agacaacatt acagccccca taggaggtat 34020 aacaaaatta ataggagaga aaaacacata aacacctgaa aaaccctcct gcctaggcaa 34080 aatagcaccc tcccgctcca gaacaacata cagcgcttcc acagcggcag ccataacagt 34140 cagccttacc agtaaaaaag aaaacctatt aaaaaaacac cactcgacac ggcaccagct 34200 caatcagtca cagtgtaaaa aagggccaag tgcagagcga gtatatatag gactaaaaaa 34260 tgacgtaacg gttaaagtcc acaaaaaaca cccagaaaac cgcacgcgaa cctacgccca 34320 gaaacgaaag ccaaaaaacc cacaacttcc tcaaatcgtc acttccgttt tcccacgtta 34380 cgtcacttcc cattttaaga aaactacaat tcccaacaca tacaagttac tccgccctaa 34440 aacctacgtc acccgccccg ttcccacgcc ccgcgccacg tcacaaactc caccccctca 34500 ttatcatatt ggcttcaatc caaaataagg tatattattg atgatg 34546 <210> 96 <211> 34331 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO202X) <400> 96 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccttatgag 3600 tggaaacgct tcttttaagg ggggagtctt cagcccttat ctgacagggc gtctcccatc 3660 ctgggcagga gttcgtcaga atgttatggg atctactgtg gatggaagac ccgtccaacc 3720 cgccaattct tcaacgctga cctatgctac tttaagttct tcacctttgg acgcagctgc 3780 agccgccgcc gccgcctctg ttgccgctaa cactgtgctt ggaatgggtt actatggaag 3840 tatcgtggct aattccactt cctctaataa cccttctacc ctgactcagg acaagttact 3900 tgtccttttg gcccagctgg aggctttgac ccaacgtctg ggtgaacttt atcagcaggt 3960 ggccgagttg cgagtacaaa ctgagtctgc tgtcggcacg gcaaagtcta aataaaacat 4020 aaataaaaaa ccagactctg tttggatttg gatcaagcaa aatcaagtgt ttttatttca 4080 tttttcgcgc acggtatgcc ctagaccacc gatctcgatc attgagaaca cggtggattt 4140 tttccagaat cctatagagg tgggattgaa tgtttagata catgggcatt aggccatctt 4200 tggggtggag atagctccat tgaagggatt catgctccgg ggtagtgttg taaatcaccc 4260 agtcataaca aggtcgcagt gcatggtgtt gcacaatatc ttttagaagt aggctgattg 4320 ccacagataa gcccttggtg taggtgttta caaaccggtt gagctgggag gggtgcattc 4380 ggggtgaaat tatgtgcatt ttggattgga tttttaagtt ggcaatattg ccgccaagat 4440 ctcgtcttgg gttcatgtta tgaaggacca ccaagacggt gtatccggta catttaggaa 4500 atttatcgtg tagcttggat ggaaaagcgt ggaaaaattt ggagacaccc ttgtgtcctc 4560 cgagattttc catgcactca tccatgataa tagcaatggg gccgtgggca gcagcgcggg 4620 caaacacgtt ccgtgggtct gacacatcat agttatgttc ctgagttaaa tcatcataag 4680 ccattttaat gaatttgggg cggagagtac ccgattgggg tatgaatgtt ccttcgggcc 4740 ccggagcata gttcccctca cagatttgca tttcccaagc tttcagttcc gatggtggaa 4800 tcatgtccac ctggggggct atgaagaaca ccgtttctgg ggcgggggtg attagttggg 4860 atgatagcaa gtttctgagc aattgagatt tgccacatcc ggtggggcca taaatgattc 4920 cgattacagg ttgcaggtgg tagtttaggg aacggcaact gccgtcttct cgaagcaagg 4980 gggccacctc gttcatcatt tcccttacat gcatattttc ccgcaccaaa tccattagga 5040 ggcgctctcc tcctagtgat agaagttctt gtagtgagga aaagtttttc agcggtttta 5100 gaccgtcagc catgggcatt ttggagagag tttgctgcaa aagttctagt ctgttccaca 5160 gttcagtgat gtgttctatg gcatctcgat ccagcagacc tcctcgtttc gcgggtttgg 5220 acggctcctg gagtagggta tgagacgatg ggcgtccagc gctgccaggg ttcggtcctt 5280 ccagggtctc agtgttcgag tcagggttgt ttccgtcaca gtgaaggggt gtgcgcctgc 5340 ttgggcgctt gccagggtgc gcttcagact cattctgctg gtggagaact tctgtcgctt 5400 ggcgccctgt atgtcggcca agtagcagtt taccatgagt tcgtagttga gcgcctcggc 5460 tgcgtggcct ttggcgcgga gcttaccttt ggaagttttc ttgcataccg ggcagtatag 5520 gcatttcagc gcatacagct tgggcgcaag gaaaatggat tctggggagt atgcatctgc 5580 gccgcaggag gcgcaaacag tttcacattc caccagccag gttaaatccg gttcattggg 5640 gtcaaaaaca agttttccgc catatttttt gatgcgtttc ttacctttgg tctccatgag 5700 ttcgtgtcct cgttgagtga caaacaggct gtccgtatcc ccgtagactg attttacagg 5760 cctcttctcc agtggagtgc ctcggtcttc ttcgtacagg aactctgacc actctgatac 5820 aaaggcgcgc gtccaggcca gcacaaagga ggctatgtgg gaggggtagc gatcgttgtc 5880 aaccaggggg tccacctttt ccaaagtatg caaacacatg tcaccctctt caacatccag 5940 gaatgtgatt ggcttgtagg tgtatttcac gtgacctggg gtccccgctg ggggggtata 6000 aaagggggcg gttctttgct cttcctcact gtcttccgga tcgctgtcca ggaacgtcag 6060 ctgttggggt aggtattccc tctcgaaggc gggcatgacc tctgcactca ggttgtcagt 6120 ttctaagaac gaggaggatt tgatattgac agtgccggtt gagatgcctt tcatgaggtt 6180 ttcgtccatt tggtcagaaa acacaatttt tttattgtca agtttggtgg caaatgatcc 6240 atacagggcg ttggataaaa gtttggcaat ggatcgcatg gtttggttct tttccttgtc 6300 cgcgcgctct ttggcagcga tgttgagttg gacatactcg cgtgctaggc acttccattc 6360 ggggaagata gttgtcaatt catctggcac gattctcact tgccaccctc gattatgcaa 6420 ggtaattaaa tccacactgg tggccacctc gcctcgaagg ggttcgttgg tccaacagag 6480 cctacctcct ttcctagaac agaaaggggg aagtgggtct agcataagtt catcgggagg 6540 gtctgcatcc atggtaaaga ttcccggaag taaatcctta tcaaaatagc tgatgggagt 6600 ggggtcatct aaggccattt gccattctcg agctgccagt gcacgctcat atgggttaag 6660 gggactgccc cagggcatgg gatgggtgag tgcagaggca tacatgccac agatgtcata 6720 gacgtagatg ggatcctcaa agatgcctat ataggttgga tagcatcgcc cccctctgat 6780 acttgctcgc acatagtcat atagttcatg tgatggcgct agcaaccccg gacccaagtt 6840 ggtgcgattg ggtttttctg ttctgtagac aatctggcga aagatggcgt gagaattgga 6900 agagatggtg ggtctttgaa aaatgttgaa atgggcatga ggtagaccta cagagtctct 6960 gacaaagtgg gcataagatt cttgaagctt ggttaccagt tcggcggtga caagtacgtc 7020 tagggcgcag tagtcaagtg tttcttgaat gatgtcataa cctggttggt ttttcttttc 7080 ccacagttcg cggttgagaa ggtattcttc gcgatccttc cagtactctt ctagcggaaa 7140 cccgtctttg tctgcacggt aagatcctag catgtagaac tgattaactg ccttgtaagg 7200 gcagcagccc ttctctacgg gtagagagta tgcttgagca gcttttcgca gcgaagcgtg 7260 agtaagggcg aaggtgtctc tgaccatgac tttgagaaat tggtatttga agtccatgtc 7320 gtcacaggct ccctgttccc agagttggaa gtctacccgt ttcttgtagg cggggttggg 7380 caaagcgaaa gtaacatcgt tgaagagaat cttaccggct ctgggcataa aattgcgagt 7440 gatgcggaaa ggctgtggta cttccgctcg attgttgatc acctgggcag ctaggacgat 7500 ctcgtcgaaa ccgttgatgt tgtgtcctac gatgtataat tctatgaaac gcggcgtgcc 7560 tttgacgtga ggtagcttat tgagctcatc aaaggttagg tctgtagggt cagataaggc 7620 gtagtgttcg agagcccatt cgtgcaggtg aggatttgca tgtaggaatg atgaccaaag 7680 atccaccgcc agtgctgttt gtaactggtc ccgatactga cgaaaatgct ggccaattgc 7740 cattttttct ggagtgacac agtagaaggt tctggggtct tgttgccatc gatcccactt 7800 tagtttaatg gctagatcgt gggccatgtt gacgagacgc tcttctcctg agagtttcat 7860 gaccagcatg aaaggaacta gttgtttgcc aaaggacccc atccaggtgt aagtttccac 7920 atcgtaggtc aggaagagtc tttctgtgcg aggatgagag ccgatcggga agaactggat 7980 ttcctgccac cagttggagg attggctgtt gatgtgatgg aagtagaagt ttctgcggcg 8040 cgccgagcat tcgtgtttgt gcttgtacag acggccgcag tagtcgcagc gttgcacggg 8100 ttgtatctcg tgaatgagct gtacctggct tcccttgacg agaaatttca gtgggaagcc 8160 gaggcctggc gattgtatct cgtgctcttc tatattcgct gtatcggcct gttcatcttc 8220 tgtttcggtg gtggtcatgc tgacgagccc ccgcgggagg caagtccaga cctcggcgcg 8280 ggaggggcgg agctgaagga ccagagcgcg caggctggag ctgtccagag tcctgagacg 8340 ctgcggactc aggttagtag gtagggacag aagattaact tgcatgatct tttccagggc 8400 gtgcgggagg ttcagatggt acttgatttc cacaggttcg tttgtagaga tgtcaatggc 8460 ttgcagggtt ccgtgtcctt tgggcgccac taccgtacct ttgttttttc ttttgatcgg 8520 tggtggctct cttgcttctt gcatgctcag aagcgatgac ggggacgcgc gccgggcgga 8580 agcggttgtt ccggacccgg aggcatggct ggtagtggca cgtcggcgcc gcgcacgggc 8640 aggttctggt actgcgctct gagaagactt gcgtgcgcca ccacgcgtcg attgacgtct 8700 tgtatctgac gtctctgggt gaaagctacc ggccccgtga gcttgaacct gaaagagagt 8760 tcaacagaat caatttcggt atcgttaacg gcagcttgtc tcagtatttc ttgtacgtca 8820 ccagagttgt cctggtaggc gatctccgcc atgaactgct cgatttcttc ctcctgaaga 8880 tctccgcgac ccgctctctc gacggtggcc gcgaggtcat tggagatacg gcccatgagt 8940 tgggagaatg cagtcatgcc cgcctcgttc cagacgcggc tgtaaaccac ggccccctcg 9000 gagtctcttg cgcgcatcac cacctgagcg aggttaagct ccacgtgtct ggtgaagacc 9060 gcatagttgc ataggcgctg aaaaaggtag ttgagtgtgg tggcaatgtg ttcggcgacg 9120 aagaaataca tgatccatcg tctcagcggc atttcgctga catcgcccag agcttccaag 9180 cgctccatgg cctcgtagaa gtccacggca aaattaaaaa actgggagtt tcgcgcggac 9240 acggtcaatt cctcctcgag aagacggatg agttcggcta tggtggcccg tacttcgcgt 9300 tcgaaggctc ccgggatctc ttcttcctct tctatctctt cttccactaa catctcttct 9360 tcgtcttcag gcgggggcgg agggggcaca cggcgacgtc gacggcgcac gggcaaacgg 9420 tcgatgaatc gttcaatgac ctctccgcgg cggcggcgca tggtttcagt gacggcgcgg 9480 ccgttctcgc gcggtcgcag agtaaaaaca ccgccgcgca tctccttaaa gtggtgactg 9540 ggaggttctc cgtttgggag ggagagggcg ctgattatac attttattaa ttggcccgta 9600 gggactgcgc gcagagatct gatcgtgtca agatccacgg gatctgaaaa cctttcgacg 9660 aaagcgtcta accagtcaca gtcacaaggt aggctgagta cggcttcttg tgggcggggg 9720 tggttatgtg ttcggtctgg gtcttctgtt tcttcttcat ctcgggaagg tgagacgatg 9780 ctgctggtga tgaaattaaa gtaggcagtt ctaagacggc ggatggtggc gaggagcacc 9840 aggtctttgg gtccggcttg ctggatacgc aggcgattgg ccattcccca agcattatcc 9900 tgacatctag caagatcttt gtagtagtct tgcatgagcc gttctacggg cacttcttcc 9960 tcacccgttc tgccatgcat acgtgtgagt ccaaacccgc gcattggttg taccagtgcc 10020 aagtcagcta cgactctttc ggcgaggatg gcttgctgta cttgggtgag ggtggcttga 10080 aagtcatcaa aatccacaaa gcggtggtaa gccccggtat taatggtgta agcacagttg 10140 gccatgactg accagttaac tgtctggtga ccagggcgca cgagctcggt gtatttaagg 10200 cgcgaatagg cgcgggtgtc aaagatgtaa tcgttgcagg tgcgcaccag atactggtaa 10260 cctataagaa aatgcggcgg tggttggcgg tagagaggcc atcgttctgt agctggagcg 10320 ccgggggcga ggtcttccaa cataaggcgg tgatagccgt agatgtacct ggacatccag 10380 gtgattcctg cggcggtagt agaagcccga ggaaactcgc gtacgcggtt ccaaatgttg 10440 cgtagcggca tgaagtagtt cattgtaggc acggtttgac cagtgaggcg cgcgcagtca 10500 ttgatgctct atagacacgg agaaaatgaa agcgttcagc gactcgactc cgtagcctgg 10560 aggaacgtga acgggttggg tcgcggtgta ccccggttcg agacttgtac tcgagccggc 10620 cggagccgcg gctaacgtgg tattggcact cccgtctcga cccagcctac aaaaatccag 10680 gatacggaat cgagtcgttt tgctggttgc cgaatggcag ggaagtgagt cctatttttt 10740 ttttttgccg ctcagatgca tcccgtgctg cgacagatgc gtccccaaca acagcccccc 10800 tcgcagcagc agcaaccaca aaaggctgtc cctgcaacta ctgcaactgc cgctgtgagc 10860 ggtgcgggac agcccgccta tgatctggac ttggaagagg gcgaaggact ggcacgtcta 10920 ggtgcgcctt cgcccgagcg gcatccgcga gttcaactga aaaaagattc tcgcgaggcg 10980 tatgtgcccc aacagaacct atttagagac agaagcggcg aggagccgga ggagatgcga 11040 gcttcccgct ttaacgcggg tcgtgagctg cgtcacggtt tggacagaag acgagtgttg 11100 cgggacgagg atttcgaagt tgatgaagtg acagggatca gtcctgccag ggcacacgtg 11160 gctgcagcca accttgtatc ggcttacgaa cagacagtaa aggaagagcg taatttccaa 11220 aagtctttta ataatcatgt gcgaaccctc attgcccgcg aagaagtcac ccttggtttg 11280 atgcatttgt gggatttgat ggaagctatc attcagaacc ctactagcaa acctctgacc 11340 gcacagctgt ttctggtggt gcaacacagc agagacaatg aggctttcag agaggcgctg 11400 ctcaacatca ccgaacccga ggggagatgg ttgtatgatc ttatcaacat tctacagagt 11460 atcatagtgc aggagcggag cctgggcctg gccgagaagg tggctgccat caattactcg 11520 gttttgagct tgggaaagta ttacgctcgc aagatctaca agactccata cgttcccata 11580 gacaaggagg tgaagataga tgggttctac atgcgcatga cgctgaaggt gttgaccctg 11640 agcgatgatc ttggggtgta ccgcaatgac agaatgcatc gcgcggtgag cgccagcagg 11700 aggcgcgagt taagcgacag ggaactgatg cacagtttgc aaagagctct aactggagct 11760 ggaaccgagg gtgagaatta ctttgatatg ggagctgact tgcagtggca gcctagtcgc 11820 agggctctga acgccgcgac ggcaggatgt gagcttcctt acatagaaga ggcggatgaa 11880 ggcgaggagg aagagggcga gtacttggaa gactgatggc acaacccgtg ttttttgcta 11940 gatggaacag caagcaccgg atcccgcaat gcgggcggcg ctgcagagcc agccgtccgg 12000 cattaactcc tcggacgatt ggacccaggc catgcaacgt atcatggcgt tgacgactcg 12060 caaccccgaa gcctttagac agcaacccca ggccaaccgt ctatcggcca tcatggaagc 12120 tgtagtgcct tcccgctcta atcccactca tgagaaggtc ctggccatcg tgaacgcgtt 12180 ggtggagaac aaagctattc gtccagatga ggccggactg gtatacaacg ctctcttaga 12240 acgcgtggct cgctacaaca gtagcaatgt gcaaaccaat ttggaccgta tgataacaga 12300 tgtacgcgaa gccgtgtctc agcgcgaaag gttccagcgc gatgccaacc tgggttcgct 12360 ggtggcgtta aatgctttct tgagtactca gcctgctaat gtgccgcgtg gtcaacagga 12420 ttatactaac tttttaagtg ctttgagact gatggtatca gaagtacctc agagcgaagt 12480 atatcagtcc ggtcctgatt acttctttca gactagcaga cagggcttgc agacggtaaa 12540 tctgagccaa gcttttaaaa accttaaagg tttgtgggga gtgcatgccc cggtaggaga 12600 aagagcaacc gtgtctagct tgttaactcc gaactcccgc ctattattac tgttggtagc 12660 tcctttcacc gacagcggta gcatcgaccg taattcctat ttgggttacc tactaaacct 12720 gtatcgcgaa gccatagggc aaagtcaggt ggacgagcag acctatcaag aaattaccca 12780 agtcagtcgc gctttgggac aggaagacac tggcagtttg gaagccactc tgaacttctt 12840 gcttaccaat cggtctcaaa agatccctcc tcaatatgct cttactgcgg aggaggagag 12900 gatccttaga tatgtgcagc agagcgtggg attgtttctg atgcaagagg gggcaactcc 12960 gactgcagca ctggacatga cagcgcgaaa tatggagccc agcatgtatg ccagtaaccg 13020 acctttcatt aacaaactgc tggactactt gcacagagct gccgctatga actctgatta 13080 tttcaccaat gccatcttaa acccgcactg gctgccccca cctggtttct acacgggcga 13140 atatgacatg cccgacccta atgacggatt tctgtgggac gacgtggaca gcgatgtttt 13200 ttcacctctt tctgatcatc gcacgtggaa aaaggaaggc ggcgatagaa tgcattcttc 13260 tgcatcgctg tccggggtca ttggtgctac cgcggctgag cccgagtctg caagtccttt 13320 tcctagtcta cccttttctc tacacagtgt acgtagcagc gaagtgggta gaataagtcg 13380 cccgagttta atgggcgaag aggagtacct aaacgattcc ttgctcagac cggcaagaga 13440 aaaaaatttc ccaaacaatg gaatagaaag tttggtggat aaaatgagta gatggaagac 13500 ttatgctcag gatcacagag acgagcctgg gatcatgggg actacaagta gagcgagccg 13560 tagacgccag cgccatgaca gacagagggg tcttgtgtgg gacgatgagg attcggccga 13620 tgatagcagc gtattggact tgggtgggag aggaaggggc aacccgtttg ctcatttgcg 13680 ccctcgcttg ggtggtatgt tgtaaaaaaa aataaaaaag aaaaaactca ccaaggccat 13740 ggcgacgagc gtacgttcgt tcttctttat tatctgtgtc tagtataatg aggcgagtcg 13800 tgctaggcgg agcggtggtg tatccggagg gtcctcctcc ttcgtacgag agcgtgatgc 13860 agcagcagca ggcgacggcg gtgatgcaat ccccactgga ggctcccttt gtgcctccgc 13920 gatacctggc acctacggag ggcagaaaca gcattcgtta ctcggaactg gcacctcagt 13980 acgataccac caggttgtat ctggtggaca acaagtcggc ggacattgct tctctgaact 14040 atcagaatga ccacagcaac ttcttgacca cggtggtgca aaacaatgac tttaccccta 14100 cggaagccag cacccagacc attaactttg atgaacgatc gcggtggggc ggtcagctaa 14160 aaaccatcat gcatactaac atgcccaacg tgaacgagta tatgtttagt aacaagttca 14220 aagcgcgtgt gatggtgtcc agaaaacctc ctgagggtgt tagagtagac gataattatg 14280 atcataagca agatattcta aaatacgagt ggttcgagtt tactttgcca gaaggcaact 14340 tttcggtcac tatgactatc gacttgatga acaatgccat catagacaat tacttgaaag 14400 tgggcagaca gaatggagtg ttggaaagtg acattggtgt taagttcgac actaggaact 14460 tcaagttggg atgggatcca gaaactaagt tgatcatgcc tggggtttac acctatgagg 14520 ccttccatcc tgacatcgta ttgctgcctg gctgcggagt ggactttacc gaaagccgtc 14580 tgagcaacct tcttggcatt agaaagaaac acccattcca agagggtttt aagatcttgt 14640 atgaggattt agaaggagga aatattccag cccttttgga tgtagatgct tatgagaaca 14700 gcaagaaaga tcaaaaagcc aaaatagaag ctgctgcaga agctaaagca aacatagttg 14760 ccaacgatcc ggtaagggtg gctaacgcta gtgaaatcag gggagacagt tttgccgcaa 14820 catccgttcc gactaaagaa tcattattgg atgatgtgtc tcaaaacata gagttaaaac 14880 tcactattaa gcctgtggaa aaagatggca aaaacagaag ttacaatgtg ttggaagata 14940 aaatcaacac ggcctatcgc agttggtacc tttcgtacaa ttatggcgac cccgaaaaag 15000 gagtgcgttc ctggacattg ctcaccacct cagatgtcac ctgcggagcg gagcaggtct 15060 actggtcgct tccagacatg atgcaggatc ctgtcacttt ccgctccact agacaagtca 15120 gtaactaccc tgtggtgggt gcagagctta tgcccgtctt ttcaaagagc ttctacaacg 15180 aacaagctgt gtactcccag cagctccgcc agtccacctc gcttacgcac gtcttcaacc 15240 gctttcctga gaaccagatt ttaatccgtc cgccggcgcc cacaattacc accgtcagtg 15300 aaaacgttcc tgctctcaca gatcacggga ccctgccgtt gcgcagcagt atccggggag 15360 tccaacgtgt gaccgttact gacgccagac gccgcacctg tccctacgtg tacaaggcac 15420 tgggcatagt cgcaccgcgc gtcctttcaa gccgcacttt ctaaaaaaaa aaaaaaaatg 15480 tccgttctta tctcgcccag taataacacc ggttggggtc tgcgcgctcc cagcaagatg 15540 tacggaggcg cacgcaaacg ttctacccaa catcccgtgc gtgttcgcgg gcattttcgc 15600 gctccatggg gtgccctcaa gggccgcact cgcgttcgaa ccaccgtcga tgatgtaatc 15660 gatcaggtgg ttgccgacgc ccgtaattat actcctactg cgcctacatc tactgtggac 15720 gcagttattg acagtgtagt ggctgacgct cgcaactatg ctcgacgtaa gagccggcga 15780 aggcgcattg ccagacgtca ccgagctacc actgccatgc gagcagcaag agctctgcta 15840 cgaagagcta gacgcgtggg gcgaagagcc atgcttaggg cggccagacg tgcagcttcg 15900 ggcgccagcg ccggcaggtc ccgcaggcaa gcagccgctg tcgcagcggc gactattgcc 15960 gacatggccc aatcgcgaag aggcaatgta tactgggtgc gtgacgctgc caccggtcaa 16020 cgtgtacccg tgcgcacccg tccccctcgc acttagaaga tactgagcag tctccgatgt 16080 tgtgtcccag cggcgaggat gtccaagcgc aaatacaagg aagaaatgct gcaggttatc 16140 gcacctgaag tctacggcca accgttgaag gatgaaaaaa aaccccgcaa aatcaagcgg 16200 gtaaaaaagg acaaaaaaga agaggaagat ggcgatgatg ggctggcgga gtttgtgcgc 16260 gagtttgccc cacggcgacg cgtgcaatgg cgtgggcgca aagttcgaca tgtgttgaga 16320 cctggaactt cggtggtctt tacacccggc gagcgttcaa gcgctacttt taagcgttcc 16380 tatgatgagg tgtacgggga tgatgatatt cttgagcagg cagctgaccg attaggcgag 16440 tttgcttatg gcaagcgtag tagaataaat cccaaggatg aaacagtgtc catacccttg 16500 gatcatggaa atcccacccc tagtcttaaa ccggtcactt tgcagcaagt gttacccgta 16560 actccgcgaa caggtgttaa acgcgaaggt gaagatttgt atcccactat gcaactgatg 16620 gtgcccaaac gccagaagtt ggaggacgtt ttggagaaag taaaagtgga tccagatatt 16680 caacctgagg ttaaagtgag acccattaag caggtagcgc ctggtctggg agtacaaact 16740 gtagacatta aaattcccac tgaaagtatg gaagtgcaaa ctgaacccgc aaagcctact 16800 gccacctcca ctgaagtgca aacggaccca tggatgccca tgcctattac aactgacgcc 16860 gtcggtccca ctcgaagatc ccgacgaaag tacggtccag caagtctgtt gatgcccaac 16920 tatgtcgtac acccatctat tattcctact cctggttacc gaggcactcg ctactatcgc 16980 agccgaaaca gtacttcccg ccgtcgccgc aagacacctg caaatcgcag tcgtcgccgt 17040 agacgcacaa gcaaaccgat tcccggcgcc ctggtgcggc aagtgtaccg caatggtagt 17100 gcggaacctt tgacactgcc gcgtgcgcgt taccatccta gtatcatcac ttaatcaatg 17160 ttgccgctgc ctccttgcag atatggccct cacttgtcgc cttcgcgttc ccatcactgg 17220 ttaccgagga agaaactcgc gccgtagaag agggatgttg gggcgcggaa tgcgacgcta 17280 caggcgacgg cgtgctatcc gcaagcaatt gcggggtggt tttttgccag ccttaattcc 17340 aattatcgct gctgcgattg gcgcaatacc aggcatagct tccgtggcgg ttcaggcctc 17400 gcaacgacat tgacattgga aaaaaaaaaa acgtataaat aaaaaataca atggactctg 17460 acactcctgg tactgtgact atgttttctt agagatggaa gacatcaatt tttcatcctt 17520 ggctccgcga cacggcacga agccgtacat gggcacctgg agcgacatcg gcacgagcca 17580 actgaacggg ggcgccttca attggagcag tatctggagc gggcttaaaa attttggctc 17640 aaccataaaa acatacggga acaaagcttg gaacagcagt acaggacagg cgcttagaaa 17700 taaacttaaa gaccagaact tccaacaaaa agtagtcgat gggatagctt ccggtatcaa 17760 tggagtggta gatttggcta accaggctgt gcagaaaaag ataaacagtc gtttggaccc 17820 gccgccagca accccaggtg aaatgcaagt ggaggaagaa attcctccgc cagaaaaacg 17880 aggcgacaag cgtccgcgtc ccgatttgga agagacgctg gtgacgcgcg tagatgaacc 17940 gccttcttat gaggaagcaa cgaagcttgg aatgcccacc actagaccga tagcccctat 18000 ggccaccggg gtgatgaaac cttctcagtt gcatcgaccc gtcaccttgg atttgccccc 18060 tcctcctgct gctactgctg tacccgcttc taagcctgtc gctgccccga aaccagtcgc 18120 cgtagccagg tcacgtcccg ggggcgctcc tcgtccaaat gcacactggc aaaatactct 18180 gaacagcatc gtgggtctag gcgtgcaaag tgtaaaacgc cgtcgctgct tttaattaaa 18240 tatggagtag cgcttaactt gcctatctgt gtatatgtgt cattacacgc cgtcacagca 18300 tcagaggaaa aaaggaagag gtcgtgcgtc gacgctgagt tactttcaag atggccaccc 18360 catcgatgct gccccaatgg gcatacatgc acatcgccgg acaggatgct tcggagtacc 18420 tgagtccggg tctggtgcag ttcgcccgcg ccacagacac ctacttcaat ctgggaaata 18480 agtttagaaa tcctaccgta gcgccgaccc acgatgtgac caccgatcgt agccagcggc 18540 tcatgttgcg cttcgtgccc gttgaccggg aggacaatac atactcttac aaagtgcggt 18600 acaccctggc cgtgggcgac aacagagtgc tggatatggc cagcacgttc tttgacatta 18660 ggggcgtgtt ggacagaggt cccagtttta aaccctattc tggtacggct tacaactccc 18720 tggctcctaa aggcgctcca aatgcatctc agtggttgga taagggagtt acaagcactg 18780 gcctagtgga cgacggcaat actgatgatg gggaagaagc caaaaaagca acatacactt 18840 ttggtaatgc tccagtaaaa gccgaggctg aaatcacaaa agacggattg ccggtgggct 18900 tggaagtttc aactgaaggt cctaaaccaa tctatgctga taagctttat cagccagaac 18960 ctcaagtggg agacgaaact tggactgacc tagacggaaa aaccgaagag tatggaggga 19020 gggttcttaa acctgaaact aaaatgaaac cctgctacgg atcttttgct aaacctacta 19080 atattaaagg aggtcaggca aaggtaaaac caaaagaaga cgatggcact aacaacatcg 19140 agtatgacat tgacatgaac ttctttgact taagatcaca aagatcagaa ctcaaaccta 19200 aaattgtaat gtatgcagaa aatgtggacc tggaatgtcc agatactcat gttgtgtaca 19260 aacctggagt ttcagatgct agttctgaga ccaatcttgg acaacagtct atgcccaaca 19320 gacccaacta cattggcttc agagataact tcatcggact tatgtactat aacagtactg 19380 gcaacatggg ggtactggct ggccaagcgt ctcagttgaa tgcagtggtt gacttgcagg 19440 acagaaacac agaactgtct taccaactct tgcttgactc tctgggcgac agaaccagat 19500 actttagcat gtggaatcag gctgtggaca gttatgatcc tgatgtacgt gttattgaaa 19560 atcatggtgt ggaagatgaa cttcccaact attgttttcc gttggatggt gtcggtccgc 19620 gaacagatag ttacaaggag attaagccaa atggagacca atctacttgg acaaatgtag 19680 acccaactgg cagcagtgaa cttgctaagg gaaatccatt tgccatggaa attaaccttc 19740 aagccaatct atggcgaagt ttcctttatt ccaatgtggc tctatatctc ccagactcgt 19800 acaaatacac cccgtccaat gtcactcttc cagaaaacaa aaacacctac gactacatga 19860 acgggcgggt ggtgccgcca tctctagtag acacctatgt gaacattggt gccaggtggt 19920 ctctggatgc catggacaat gtcaacccat tcaaccacca ccgtaacgct ggcttgcgtt 19980 accgatccat gcttctgggt aacggacgtt atgtgccttt ccacatacaa gtgcctcaaa 20040 aattcttcgc tgttaaaaac ctgctgcttc tcccaggctc ctacacttat gagtggaact 20100 ttaggaagga tgtaaacatg gttctacaga gttccctcgg taacgaccta cgggtagatg 20160 gcgccagcat cagttttacg agcatcaacc tctatgctac ttttttcccc atggctcaca 20220 acaccgcttc cacccttgaa gccatgctgc ggaatgacac caatgatcag tcattcaacg 20280 actacctatc tgcagctaac atgctctacc ccattcctgc caatgcaacc aatattccca 20340 tttccattcc ttctcgcaac tgggcggctt tcagaggctg gtcatttacc agactgaaaa 20400 ccaaagaaac tccctctttg gggtctggat ttgaccccta cttcgtctat tctggttcta 20460 ttccctacct ggatggtacc ttctacctga accacacttt taagaaggtt tccatcatgt 20520 ttgactcttc agtgagctgg cctggaaatg acaggttact atctcctaac gaatttgaaa 20580 taaagcgcac tgtggatggc gaaggctaca acgtagccca atgcaacatg accaaagact 20640 ggttcttggt acagatgctc gccaactaca acatcggcta tcagggcttc tacattccag 20700 aaggatacaa agatcgcatg tattcatttt tcagaaactt ccagcccatg agcaggcagg 20760 tggttgatga ggtcaattac aaagacttca aggccgtcgc cataccctac caacacaaca 20820 actctggctt tgtgggttac atggctccga ccatgcgtca aggtcaaccc tatcccgcta 20880 actatcccta tccactcatt ggaacaactg ccgtaaatag tgttacgcag aaaaagttct 20940 tgtgtgacag aaccatgtgg cgcataccgt tctcaagcaa cttcatgtct atgggagccc 21000 ttacagactt gggacagaac atgctctatg ccaactcagc tcatgctctg gacatgacct 21060 ttgaggtgga tcccatggat gagcccaccc tgctttatct tctcttcgaa gttttcgacg 21120 tggtcagagt gcatcagcca caccgcggca tcatcgaggc agtctacctg cgtacaccgt 21180 tctcggccgg taacgctacc acgtaagaag cttcttgctt cttgcaaaca gcagctgcaa 21240 ccatggcctg cggatcccaa aacggctcca gcgagcaaga gctcagagcc attgtccaag 21300 acctgggttg cggaccatat tttttgggaa cctttgataa gcgcttcccg gggttcatgg 21360 cccccgataa gctcgcctgt gccattgtaa atacggccgg acgtgagacg gggggagagc 21420 actggttggc tttcggttgg aacccacgtt ctaacacctg ctaccttttt gatccttttg 21480 gattctcgga tgatcgtctc aaacagattt accagtttga atatgagggt ctcctgcgcc 21540 gcagcgctct tgctaccaag gaccggtgta ttacgctgga aaaatctacc cagaccgtgc 21600 agggcccccg ttctgccgcc tgcggacttt tctgctgcat gttccttcat gcctttgtgc 21660 actggcctga ccgtcccatg gacggaaacc ccaccatgaa attgctaact ggagtgccaa 21720 acaacatgct tcattctcct aaagtccagc ccaccctgtg tgacaatcaa aaagcactct 21780 accattttct caatacccat tcgccttatt ttcgctctca tcgtacacac atcgaaaggg 21840 ccactgcgtt cgaccgtatg gatgtgcaat aatgattcat gtaaacaacg tgttcaataa 21900 acagcacttt attttttaca tgtatcgagg ctctggatta cttatttatt tacaagtcga 21960 atgggttctg acgagaatca gaatgacccg caggcagtga tacgttgcgg aactgatact 22020 tgggttgcca cttgaattcg ggaatcacca acttgggaac cggtatatcg ggcaggatgt 22080 cactccacag ctttctggtc agctgcaaag ctcccagcag gtcaggagcc gaaatcttga 22140 aatcacaatt aggaccagtg ctctgagcgc gagagttgcg gtacaccgga ttgcagcact 22200 gaaacaccat cagcgacgga tgtcttacgc ttgccagcac ggtgggatct gcaatcatgc 22260 ccacatccag atcttcagca ttggcaatgc tgaacggggt catcttgcag gtctgcctac 22320 ccatggcggg cacccaatta ggcttgtggt tacaatcgca gtgcaggggg atcagtatca 22380 tcttggcctg atcctgtctg attcctggat acacggctct catgaaagca tcatattgct 22440 tgaaagcctg ctgggcttta ctaccctcgg tataaaacat cccgcaggac ctgctcgaaa 22500 actggttagc tgcgcagccg gcatcattca cacagcagcg ggcgtcattg ttggctattt 22560 gcaccacact tctgccccag cggttttggg tgattttggt tcgctcggga ttctccttca 22620 aggctcgttg tccgttctcg ctggccacat ccatctcgat aatctgctcc ttctgaatca 22680 taatattgcc atgcaagcac ttcagcttgc cctcataatc attgcagcca tgaggccaca 22740 acgcacagcc tgtacattcc caattatggt gggcgatctg agaaaaagaa tgtatcattc 22800 cctgcagaaa tcttcccatc atcgtgctca gtgtcttgtg actagtgaaa gttaactgga 22860 tgcctcggtg ctcctcgttc acgtactggt gacagatgcg cttgtattgt tcgtgctgct 22920 caggcattag tttaaaagag gttctaagtt cgttatccag cctgtacttc tccatcagca 22980 gacacatcac ttccatgcct ttctcccaag cagacaccag gggcaagcta atcggattct 23040 taacagtgca ggcagcagct cctttagcca gagggtcatc tttggcgatc ttctcaatgc 23100 ttcttttgcc atccttctca acgatgcgca cgggcgggta gctgaaaccc actgctacaa 23160 gttgcgcctc ttctctttct tcttcgctgt cttgactgat gtcttgcatg gggacatgtt 23220 tggtcttcct tggcttcttt ttcgggggta tcggaggagg aggactgtcg ctccgttccg 23280 gagacaggga ggattgtgac gtttcgctca ccattaccaa ctgactgtcg gtagaagaac 23340 ctgaccccac acggcgacag gtgtttctct tcgggggcag aggtggaggc gattgcgaag 23400 ggctgcggtc cgacctggaa ggcggatgac tggcagaacc ccttccgcgt tcgggggtgt 23460 gctccctgtg gcggtcgctt aactgatttc cttcgcggct ggccattgtg ttctcctagg 23520 cagagaaaca acagacatgg aaactcagcc attgctgtca acatcgccac gagtgccatc 23580 acatctcgtc ctcagcgacg aggaaaagga gcagagctta agcattccac cgcccagtcc 23640 tgccaccacc tctaccctag aagataagga ggtcgacgca tctcatgaca tgcagaataa 23700 aaaagcgaaa gagtctgagc cagacatcga acaagacccg ggctatgtga caccggtgga 23760 acacgaggaa gagttgaaac gctttctaga gagagaggat gaaaactgcc caaaacagca 23820 agcggataac tatcaccaag atgctggaaa tagggatcag aacaccgact acctcatagg 23880 gcttgacggg gaagacgcgc tccttaaaca tctagcaaga cagtcactca tagtcaagga 23940 tgcattattg gacagaactg aagtgcccat cagtgtcgaa gagctcagcc gcgcctacga 24000 gcttaaccta ttttcacctc gtactccccc caaacgtcag ccaaacggca cctgcgagcc 24060 aaatcctcgc ttaaactttt atccagcttt tgctgtgcca gaagtactgg ctacctatca 24120 catctttttt aaaaatcaaa aaattccagt ctcctgccgc gctaatcgca cccgcgccga 24180 tgccctactc aatctgggac ctggttcacg cttacctgat atagcttcct tggaagaggt 24240 tccaaagatc ttcgagggtc tgggcaataa tgagactcgg gccgcaaatg ctctgcaaaa 24300 gggagaaaat ggcatggatg agcatcacag cgttctggtg gaattggaag gcgataatgc 24360 cagactcgca gtactcaagc gaagcgtcga ggtcacacac tttgcatacc ccgctgtcaa 24420 cctgccccct aaagtcatga cggccgtcat ggaccagtta ctcattaagc gcgcaagtcc 24480 cctttcagaa gacatgcatg acccagatgc ctgtgatgag ggtaaaccag tggtcagtga 24540 tgagcagcta acccgatggc tgggcaccga ctctccccgg gatttggaag agcgtcgcaa 24600 gcttatgatg gccgtggtgc tggttaccgt agaactagag tgtcttcggc gtttctttac 24660 cgattcagaa accttgcgca aactcgaaga gaatctgcac tacactttta gacacggctt 24720 tgtgcggcag gcatgcaaga tatctaacgt ggaactcacc aacctggttt cctacatggg 24780 tattctgcat gagaatcgcc taggacaaag cgtgctgcac agcaccctta agggggaagc 24840 ccgccgtgat tacatccgcg attgtgttta tctctacctg tgccacacgt ggcaaaccgg 24900 catgggtgta tggcagcaat gtttagaaga acagaacctg aaagagctaa acaagctctt 24960 acagaaatct cttaaggttc tgtggacagg gttcgacgag cgcaccgtcg cttccgacct 25020 ggcagacctc atcttcccag agcgtctcag ggttactttg cgaaacggac tgcctgactt 25080 tatgagccag agcatgctta acaattttcg ctctttcatc ctggaacgct ccggtatcct 25140 gcccgccacc tgctgcgcac tgccctccga ctttgtgcct ctcacctacc gcgaatgccc 25200 cccgccgcta tggagtcact gctacctgtt ccgtctggcc aactacctct cctaccactc 25260 ggatgtgatc gaggatgtga gcggagacgg cttgctggag tgtcactgcc gctgcaatct 25320 gtgcacgccc caccggtccc tagcttgcaa cccccagttg atgagcgaaa cccagataat 25380 aggcaccttt gaattgcaag gccccagcag ccaaggcgat gggtcttctc ctgggcaaag 25440 tttaaaactg accccgggac tgtggacctc cgcctacttg cgcaagtttg ccccggaaga 25500 ttaccacccc tatgaaatca agttctatga ggaccaatca cagcctccga aagccgaact 25560 ttcggcctgc gtcatcaccc agggggcaat tctggcccaa ttgcaagcca tccaaaaatc 25620 ccgccaagaa tttctactga aaaagggtaa gggggtctac cttgaccccc agaccggcga 25680 ggaactcaac acaaggttcc ctcaggatgt cccaacgacg agaaagcaag aagttgaagg 25740 tgcagccgcc gcccccagaa gatatggagg aagattggga cagtcaggca gaggaagcgg 25800 aggaggagga cagtctggag gacagtctgg aggaagacag tttggaggag gaaaacgagg 25860 aggcagagga ggtggaagaa gtaaccgccg acaaacagtt atcctcggct gcggagacaa 25920 gcaacagcgc taccatctcc gctccgagtc gaggaacccg gcggcgtccc agcagtagat 25980 gggacgagac cggacgcttc ccgaacccaa ccagcgcttc caagaccggt aagaaggatc 26040 ggcagggata caagtcctgg cgggggcata agaatgccat catctcctgc ttgcatgagt 26100 gcgggggcaa catatccttc acgcggcgct acttgctatt ccaccatggg gtgaactttc 26160 cgcgcaatgt tttgcattac taccgtcacc tccacagccc ctactatagc cagcaaatcc 26220 cggcagtctc gacagataaa gacagcggcg gcgacctcca acagaaaacc agcagcggca 26280 gttagaaaat acacaacaag tgcagcaaca ggaggattaa agattacagc caacgagcca 26340 gcgcaaaccc gagagttaag aaatcggatc tttccaaccc tgtatgccat cttccagcag 26400 agtcggggcc aagagcagga actgaaaata aaaaaccgat ctctgcgttc gctcaccaga 26460 agttgtttgt atcacaagag cgaagatcaa cttcagcgca ctctcgagga cgccgaggct 26520 ctcttcaaca agtactgcgc gctgactctt aaagagtagg cagcgaccgc gcttattcaa 26580 aaaaggcggg aattacatca tcctcgacat gagtaaagaa attcccacgc cttacatgtg 26640 gagttatcag ccccaaatgg gattggcggc aggcgcctcc caggactact ccacccgcat 26700 gaattggctc agcgccgggc cttctatgat ttctcgagtt aatgatatac gcgcctaccg 26760 aaaccaaata cttttggaac agtcagctct taccaccacg ccccgccaac accttaatcc 26820 cagaaattgg cccgccgccc tagtgtacca ggaaagtccc gctcccacca ctgtattact 26880 tcctcgagac gcccaggccg aagtccaaat gactaatgca ggtgcgcagt tagcgggcgg 26940 ctccacccta tgtcgtcaca ggcctcggca taatataaaa cgcctgatga tcagaggccg 27000 aggtatccag ctcaacgacg agtcggtgag ctctccgctt ggtctacgac cagacggaat 27060 ctttcagatt gccggctgcg ggagatcttc cttcacccct cgtcaggctg ttctgacttt 27120 ggaaagttcg tcttcgcaac cccgctcggg cggaatcggg accgttcaat ttgtggagga 27180 gtttactccc tctgtctact tcaacccctt ctccggatct cctgggcact acccggacga 27240 gttcataccg aacttcgacg cgattagcga gtcagtggac ggctacgatt gagtttatgt 27300 taagtggaga ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc cgccacaagt 27360 gctttgcccg cgactccggt gagttttgct actttgaatt gcccgaggat catatcgagg 27420 gcccggcgca cggcgtccgg cttaccgccc agggagagct tgcccgtagc ctgattcggg 27480 agtttaccca gcgccccctg ctagttgagc gggacagggg accctgtgtt ctcactgtga 27540 tttgcaactg tcctaaccct ggattacatc aagatctttg ttgccatctc tgtgctgagt 27600 ataataaata cagaaattaa aatatactgg ggctcctatc gccatcctgt aaacgccacc 27660 gtcttcaccc gcccaagcaa accaaggcga accttacctg gtacttttaa catctctccc 27720 tctgtgattt acaacagttt caacccagac ggagtgagtc tacgagagaa cctctccgag 27780 ctcagctact ccatcagaaa aaacaccacc ctccttacct gccgggaacg tacgagtgcg 27840 tcaccggccg ctgcaccaca cctaccgcct gaccgtaaac cagacttttt ccggacagac 27900 ctcaataact ctgtttacca gaacaggagg tgagcttaga aaacccttag ggtattaggc 27960 caaaggcgca gctactgtgg ggtttatgaa caattcaagc aactctacgg gctattctaa 28020 ttcaggtttc tctagaatcg gggttggggt tattctctgt cttgtgattc tctttattct 28080 tatactaacg cttctctgcc taaggctcgc cgcctgctgt gtgcacattt gcatttattg 28140 tcagcttttt aaacgctggg gtcgccaccc aagatgatta ggtacataat cctaggttta 28200 ctcacccttg cgtcagccca cggtaccacc caaaaggtgg attttaagga gccagcctgt 28260 aatgttacat tcgcagctga agctaatgag tgcaccactc ttataaaatg caccacagaa 28320 catgaaaagc tgcttattcg ccacaaaaac aaaattggca agtatgctgt ttatgctatt 28380 tggcagccag gtgacactac agagtataat gttacagttt tccagggtaa aagtcataaa 28440 acttttatgt atacttttcc attttatgaa atgtgcgaca ttaccatgta catgagcaaa 28500 cagtataagt tgtggccccc acaaaattgt gtggaaaaca ctggcacttt ctgctgcact 28560 gctatgctaa ttacagtgct cgctttggtc tgtaccctac tctatattaa atacaaaagc 28620 agacgcagct ttattgagga aaagaaaatg ccttaattta ctaagttaca aagctaatgt 28680 caccactaac tgctttactc gctgcttgca aaacaaattc aaaaagttag cattataatt 28740 agaataggat ttaaaccccc cggtcatttc ctgctcaata ccattcccct gaacaattga 28800 ctctatgtgg gatatgctcc agcgctacaa ccttgaagtc aggcttcctg gatgtcagca 28860 tctgactttg gccagcacct gtcccgcgga tttgttccag tccaactaca gcgacccacc 28920 ctaacagaga tgaccaacac aaccaacgcg gccgccgcta ccggacttac atctaccaca 28980 aatacacccc aagtttctgc ctttgtcaat aactgggata acttgggcat gtggtggttc 29040 tccatagcgc ttatgtttgt atgccttatt attatgtggc tcatctgctg cctaaagcgc 29100 aaacgcgccc gaccacccat ctatagtccc atcattgtgc tacacccaaa caatgatgga 29160 atccatagat tggacggact gaaacacatg ttcttttctc ttacagtatg attaaatgag 29220 acatgattcc tcgagttttt atattactga cccttgttgc gcttttttgt gcgtgctcca 29280 cattggctgc ggtttctcac atcgaagtag actgcattcc agccttcaca gtctatttgc 29340 tttacggatt tgtcaccctc acgctcatct gcagcctcat cactgtggtc atcgccttta 29400 tccagtgcat tgactgggtc tgtgtgcgct ttgcatatct cagacaccat ccccagtaca 29460 gggacaggac tatagctgag cttcttagaa ttctttaatt atgaaattta ctgtgacttt 29520 tctgctgatt atttgcaccc tatctgcgtt ttgttccccg acctccaagc ctcaaagaca 29580 tatatcatgc agattcactc gtatatggaa tattccaagt tgctacaatg aaaaaagcga 29640 tctttccgaa gcctggttat atgcaatcat ctctgttatg gtgttctgca gtaccatctt 29700 agccctagct atatatccct accttgacat tggctggaac gcaatagatg ccatgaacca 29760 cccaactttc cccgcgcccg ctatgcttcc actgcaacaa gttgttgccg gcggctttgt 29820 cccagccaat cagcctcgcc caccttctcc cacccccact gaaatcagct actttaatct 29880 aacaggagga gatgactgac accctagatc tagaaatgga cggaattatt acagagcagc 29940 gcctgctaga aagacgcagg gcagcggccg agcaacagcg catgaatcaa gagctccaag 30000 acatggttaa cttgcaccag tgcaaaaggg gtatcttttg tctggtaaag caggccaaag 30060 tcacctacga cagtaatacc accggacacc gccttagcta caagttgcca accaagcgtc 30120 agaaattggt ggtcatggtg ggagaaaagc ccattaccat aactcagcac tcggtagaaa 30180 ccgaaggctg cattcactca ccttgtcaag gacctgagga tctctgcacc cttattaaga 30240 ccctgtgcgg tctcaaagat cttattccct ttaactaata aaaaaaaata ataaagctta 30300 atcacttact tgaaatcagc aataaggtct ctgttgaaat tttctcccag cagcacctca 30360 cttccctctt cccaactctg gtattctaaa ccccgttcag cggcatactt tctccatact 30420 ttaaagggga tgtcaaattt tagctcctct cctgtaccca caatcttcat gtctttcttc 30480 ccagatgacc aagagagtcc ggctcagtga ctccttcaac cctgtctacc cctatgaaga 30540 tgaaagcacc tcccaacacc cctttataaa cccagggttt atttccccaa atggcttcac 30600 acaaagccca gacggagttc ttactttaaa atgtttaacc ccactaacaa ccacaggcgg 30660 atctctacag ctaaaagtgg gagggggact tacagtggat gacactgatg gtaccttaca 30720 agaaaacata cgtgctacag cacccattac taaaaataat cactctgtag aactatccat 30780 tggaaatgga ttagaaactc aaaacaataa actatgtgcc aaattgggaa atgggttaaa 30840 atttaacaac ggtgacattt gtataaagga tagtattaac accttatgga ctggaataaa 30900 ccctccacct aactgtcaaa ttgtggaaaa cactaataca aatgatggca aacttacttt 30960 agtattagta aaaaacggag ggcttgttaa tggctacgtg tctctagttg gtgtatcaga 31020 cactgtgaac caaatgttca cacaaaagac agcaaacatc caattaagat tatattttga 31080 ctcttctgga aatctattaa ctgatgaatc agacttaaaa attccactta aaaataaatc 31140 ttctacagcg accagtgaaa ctgtagccag cagcaaagcc tttatgccaa gtactacagc 31200 ttatcccttc aacaccacta ctagggatag tgaaaactac attcatggaa tatgttacta 31260 catgactagt tatgatagaa gtctatttcc cttgaacatt tctataatgc taaacagccg 31320 tatgatttct tccaatgttg cctatgccat acaatttgaa tggaatctaa atgcaagtga 31380 atctccagaa agcaacatag ctacgctgac cacatccccc tttttctttt cttacattac 31440 agaagacgac aactaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat 31500 tgcagaaaat ttcgaatcat ttttcattca gtagtatagc cccaccacca catagcttat 31560 acagatcacc gtaccttaat caaacctaca tgggggtaga gtcataatcg tgcatcagga 31620 tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc tccgtcctgc 31680 aggaatacaa catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc 31740 gccttgtcct ccgggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc 31800 agcacagcac cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca 31860 tggcggggac cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc 31920 gacccctcat aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca 31980 cctcccggta ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc 32040 agctggccaa aacctgcccg ccggctatac actgcaggga accgggactg gaacaatgac 32100 agtggagagc ccaggactcg taaccatgga tcatcatgct cgtcatgata tcaatgttgg 32160 cacaacacag gcacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa 32220 ccatatccca gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac 32280 ctcgcacgta actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat 32340 cctccagtat ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg 32400 gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt catgccaaat ggaacgccgg 32460 acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc 32520 cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca 32580 tccaggcgcc ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata 32640 acatccacca ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca 32700 cacacgggag gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt 32760 atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc 32820 aaactctaca gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa 32880 aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc 32940 ctctataaac attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct 33000 caatatatct ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag 33060 agcgccctcc accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca 33120 cagacctgta taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc 33180 cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc 33240 ccgccaggaa ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg 33300 ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg 33360 ctgctcaaaa aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta gtcatgctca 33420 tgcagataaa ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca 33480 aacatgtctg cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat 33540 tagaagcctg tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca 33600 tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct 33660 cggtcatgtc cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg 33720 tcagtgctaa aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca 33780 acattacagc ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac 33840 ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg 33900 cttccacagc ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa 33960 aacaccactc gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag 34020 agcgagtata tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag 34080 aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa 34140 tcgtcacttc cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca 34200 acacatacaa gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg 34260 ccacgtcaca aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat 34320 tattgatgat g 34331 <210> 97 <211> 35033 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO335B-TK) <400> 97 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atgctggctt tccacccagt gacgacgagg atgaagaggg 960 tgaggagttt gtgttagatt atgtggagca ccccgggcac ggttgcaggt cttgtcatta 1020 tcaccggagg aatacggggg acccagatat tatgtgttcg ctttgctata tgaggacctg 1080 tggcatgttt gtctacagta agtgaaaatt atgggcagtg ggtgatagag tggtgggttt 1140 ggtgtggtaa tttttttttt aatttttaca gttttgtggt ttaaagaatt ttgtattgtg 1200 atttttttaa aaggtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct 1260 gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct 1320 gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct 1380 cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt 1440 gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg 1500 gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta 1560 acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac 1620 ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc 1680 ttggttacat ctgacctcat ggaggcttgg gagtgtttgg aagatttttc tgctgtgcgt 1740 aacttgctgg aacagagctc taacagtacc tcttggtttt ggaggtttct gtggggctca 1800 tcccaggcaa agttagtctg cagaattaag gaggattaca agtgggaatt tgaagagctt 1860 ttgaaatcct gtggtgagct gtttgattct ttgaatctgg gtcaccaggc gcttttccaa 1920 gagaaggtca tcaagacttt ggatttttcc acaccggggc gcgctgcggc tgctgttgct 1980 tttttgagtt ttataaagga taaatggagc gaagaaaccc atctgagcgg ggggtacctg 2040 ctggattttc tggccatgca tctgtggaga gcggttgtga gacacaagaa tcgcctgcta 2100 ctgttgtctt ccgtccgccc ggcgataata ccgacggagg agcagcagca gcagcaggag 2160 gaagccaggc ggcggcggca ggagcagagc ccatggaacc cgagagccgg cctggaccct 2220 cgggaatgaa tgttgtacag gtggctgaac tgtatccaga actgagacgc attttgacaa 2280 ttacagagga tgggcagggg ctaaaggggg taaagaggga gcggggggct tgtgaggcta 2340 cagaggaggc taggaatcta gcttttagct taatgaccag acaccgtcct gagtgtatta 2400 cttttcaaca gatcaaggat aattgcgcta atgagcttga tctgctggcg cagaagtatt 2460 ccatagagca gctgaccact tactggctgc agccagggga tgattttgag gaggctatta 2520 gggtatatgc aaaggtggca cttaggccag attgcaagta caagatcagc aaacttgtaa 2580 atatcaggaa ttgttgctac atttctggga acggggccga ggtggagata gatacggagg 2640 atagggtggc ctttagatgt agcatgataa atatgtggcc gggggtgctt ggcatggacg 2700 gggtggttat tatgaatgta aggtttactg gccccaattt tagcggtacg gttttcctgg 2760 ccaataccaa ccttatccta cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg 2820 aagcctggac cgatgtaagg gttcggggct gtgcctttta ctgctgctgg aagggggtgg 2880 tgtgtcgccc caaaagcagg gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg 2940 gtatcctgtc tgagggtaac tccagggtgc gccacaatgt ggcctccgac tgtggttgct 3000 tcatgctagt gaaaagcgtg gctgtgatta agcataacat ggtatgtggc aactgcgagg 3060 acagggcctc tcagatgctg acctgctcgg acggcaactg tcacctgctg aagaccattc 3120 acgtagccag ccactctcgc aaggcctggc cagtgtttga gcataacata ctgacccgct 3180 gttccttgca tttgggtaac aggagggggg tgttcctacc ttaccaatgc aatttgagtc 3240 acactaagat attgcttgag cccgagagca tgtccaaggt gaacctgaac ggggtgtttg 3300 acatgaccat gaagatctgg aaggtgctga ggtacgatga gacccgcacc aggtgcagac 3360 cctgcgagtg tggcggtaaa catattagga accagcctgt gatgctggat gtgaccgagg 3420 agctgaggcc cgatcacttg gtgctggcct gcacccgcgc tgagtttggc tctagcgatg 3480 aagatacaga ttgaggtact gaaatgtgtg ggcgtggctt aagggtggga aagaatatat 3540 aaggtggggg tcttatgtag ttttgtatct gttttgcagc agccgccgcc gccttatgag 3600 tggaaacgct tcttttaagg ggggagtctt cagcccttat ctgacagggc gtctcccatc 3660 ctgggcagga gttcgtcaga atgttatggg atctactgtg gatggaagac ccgtccaacc 3720 cgccaattct tcaacgctga cctatgctac tttaagttct tcacctttgg acgcagctgc 3780 agccgccgcc gccgcctctg ttgccgctaa cactgtgctt ggaatgggtt actatggaag 3840 tatcgtggct aattccactt cctctaataa cccttctacc ctgactcagg acaagttact 3900 tgtccttttg gcccagctgg aggctttgac ccaacgtctg ggtgaacttt atcagcaggt 3960 ggccgagttg cgagtacaaa ctgagtctgc tgtcggcacg gcaaagtcta aataaaacat 4020 aaataaaaaa ccagactctg tttggatttg gatcaagcaa aatcaagtgt ttttatttca 4080 tttttcgcgc acggtatgcc ctagaccacc gatctcgatc attgagaaca cggtggattt 4140 tttccagaat cctatagagg tgggattgaa tgtttagata catgggcatt aggccatctt 4200 tggggtggag atagctccat tgaagggatt catgctccgg ggtagtgttg taaatcaccc 4260 agtcataaca aggtcgcagt gcatggtgtt gcacaatatc ttttagaagt aggctgattg 4320 ccacagataa gcccttggtg taggtgttta caaaccggtt gagctgggag gggtgcattc 4380 ggggtgaaat tatgtgcatt ttggattgga tttttaagtt ggcaatattg ccgccaagat 4440 ctcgtcttgg gttcatgtta tgaaggacca ccaagacggt gtatccggta catttaggaa 4500 atttatcgtg tagcttggat ggaaaagcgt ggaaaaattt ggagacaccc ttgtgtcctc 4560 cgagattttc catgcactca tccatgataa tagcaatggg gccgtgggca gcagcgcggg 4620 caaacacgtt ccgtgggtct gacacatcat agttatgttc ctgagttaaa tcatcataag 4680 ccattttaat gaatttgggg cggagagtac ccgattgggg tatgaatgtt ccttcgggcc 4740 ccggagcata gttcccctca cagatttgca tttcccaagc tttcagttcc gatggtggaa 4800 tcatgtccac ctggggggct atgaagaaca ccgtttctgg ggcgggggtg attagttggg 4860 atgatagcaa gtttctgagc aattgagatt tgccacatcc ggtggggcca taaatgattc 4920 cgattacagg ttgcaggtgg tagtttaggg aacggcaact gccgtcttct cgaagcaagg 4980 gggccacctc gttcatcatt tcccttacat gcatattttc ccgcaccaaa tccattagga 5040 ggcgctctcc tcctagtgat agaagttctt gtagtgagga aaagtttttc agcggtttta 5100 gaccgtcagc catgggcatt ttggagagag tttgctgcaa aagttctagt ctgttccaca 5160 gttcagtgat gtgttctatg gcatctcgat ccagcagacc tcctcgtttc gcgggtttgg 5220 acggctcctg gagtagggta tgagacgatg ggcgtccagc gctgccaggg ttcggtcctt 5280 ccagggtctc agtgttcgag tcagggttgt ttccgtcaca gtgaaggggt gtgcgcctgc 5340 ttgggcgctt gccagggtgc gcttcagact cattctgctg gtggagaact tctgtcgctt 5400 ggcgccctgt atgtcggcca agtagcagtt taccatgagt tcgtagttga gcgcctcggc 5460 tgcgtggcct ttggcgcgga gcttaccttt ggaagttttc ttgcataccg ggcagtatag 5520 gcatttcagc gcatacagct tgggcgcaag gaaaatggat tctggggagt atgcatctgc 5580 gccgcaggag gcgcaaacag tttcacattc caccagccag gttaaatccg gttcattggg 5640 gtcaaaaaca agttttccgc catatttttt gatgcgtttc ttacctttgg tctccatgag 5700 ttcgtgtcct cgttgagtga caaacaggct gtccgtatcc ccgtagactg attttacagg 5760 cctcttctcc agtggagtgc ctcggtcttc ttcgtacagg aactctgacc actctgatac 5820 aaaggcgcgc gtccaggcca gcacaaagga ggctatgtgg gaggggtagc gatcgttgtc 5880 aaccaggggg tccacctttt ccaaagtatg caaacacatg tcaccctctt caacatccag 5940 gaatgtgatt ggcttgtagg tgtatttcac gtgacctggg gtccccgctg ggggggtata 6000 aaagggggcg gttctttgct cttcctcact gtcttccgga tcgctgtcca ggaacgtcag 6060 ctgttggggt aggtattccc tctcgaaggc gggcatgacc tctgcactca ggttgtcagt 6120 ttctaagaac gaggaggatt tgatattgac agtgccggtt gagatgcctt tcatgaggtt 6180 ttcgtccatt tggtcagaaa acacaatttt tttattgtca agtttggtgg caaatgatcc 6240 atacagggcg ttggataaaa gtttggcaat ggatcgcatg gtttggttct tttccttgtc 6300 cgcgcgctct ttggcagcga tgttgagttg gacatactcg cgtgctaggc acttccattc 6360 ggggaagata gttgtcaatt catctggcac gattctcact tgccaccctc gattatgcaa 6420 ggtaattaaa tccacactgg tggccacctc gcctcgaagg ggttcgttgg tccaacagag 6480 cctacctcct ttcctagaac agaaaggggg aagtgggtct agcataagtt catcgggagg 6540 gtctgcatcc atggtaaaga ttcccggaag taaatcctta tcaaaatagc tgatgggagt 6600 ggggtcatct aaggccattt gccattctcg agctgccagt gcacgctcat atgggttaag 6660 gggactgccc cagggcatgg gatgggtgag tgcagaggca tacatgccac agatgtcata 6720 gacgtagatg ggatcctcaa agatgcctat ataggttgga tagcatcgcc cccctctgat 6780 acttgctcgc acatagtcat atagttcatg tgatggcgct agcaaccccg gacccaagtt 6840 ggtgcgattg ggtttttctg ttctgtagac aatctggcga aagatggcgt gagaattgga 6900 agagatggtg ggtctttgaa aaatgttgaa atgggcatga ggtagaccta cagagtctct 6960 gacaaagtgg gcataagatt cttgaagctt ggttaccagt tcggcggtga caagtacgtc 7020 tagggcgcag tagtcaagtg tttcttgaat gatgtcataa cctggttggt ttttcttttc 7080 ccacagttcg cggttgagaa ggtattcttc gcgatccttc cagtactctt ctagcggaaa 7140 cccgtctttg tctgcacggt aagatcctag catgtagaac tgattaactg ccttgtaagg 7200 gcagcagccc ttctctacgg gtagagagta tgcttgagca gcttttcgca gcgaagcgtg 7260 agtaagggcg aaggtgtctc tgaccatgac tttgagaaat tggtatttga agtccatgtc 7320 gtcacaggct ccctgttccc agagttggaa gtctacccgt ttcttgtagg cggggttggg 7380 caaagcgaaa gtaacatcgt tgaagagaat cttaccggct ctgggcataa aattgcgagt 7440 gatgcggaaa ggctgtggta cttccgctcg attgttgatc acctgggcag ctaggacgat 7500 ctcgtcgaaa ccgttgatgt tgtgtcctac gatgtataat tctatgaaac gcggcgtgcc 7560 tttgacgtga ggtagcttat tgagctcatc aaaggttagg tctgtagggt cagataaggc 7620 gtagtgttcg agagcccatt cgtgcaggtg aggatttgca tgtaggaatg atgaccaaag 7680 atccaccgcc agtgctgttt gtaactggtc ccgatactga cgaaaatgct ggccaattgc 7740 cattttttct ggagtgacac agtagaaggt tctggggtct tgttgccatc gatcccactt 7800 tagtttaatg gctagatcgt gggccatgtt gacgagacgc tcttctcctg agagtttcat 7860 gaccagcatg aaaggaacta gttgtttgcc aaaggacccc atccaggtgt aagtttccac 7920 atcgtaggtc aggaagagtc tttctgtgcg aggatgagag ccgatcggga agaactggat 7980 ttcctgccac cagttggagg attggctgtt gatgtgatgg aagtagaagt ttctgcggcg 8040 cgccgagcat tcgtgtttgt gcttgtacag acggccgcag tagtcgcagc gttgcacggg 8100 ttgtatctcg tgaatgagct gtacctggct tcccttgacg agaaatttca gtgggaagcc 8160 gaggcctggc gattgtatct cgtgctcttc tatattcgct gtatcggcct gttcatcttc 8220 tgtttcggtg gtggtcatgc tgacgagccc ccgcgggagg caagtccaga cctcggcgcg 8280 ggaggggcgg agctgaagga ccagagcgcg caggctggag ctgtccagag tcctgagacg 8340 ctgcggactc aggttagtag gtagggacag aagattaact tgcatgatct tttccagggc 8400 gtgcgggagg ttcagatggt acttgatttc cacaggttcg tttgtagaga tgtcaatggc 8460 ttgcagggtt ccgtgtcctt tgggcgccac taccgtacct ttgttttttc ttttgatcgg 8520 tggtggctct cttgcttctt gcatgctcag aagcgatgac ggggacgcgc gccgggcgga 8580 agcggttgtt ccggacccgg aggcatggct ggtagtggca cgtcggcgcc gcgcacgggc 8640 aggttctggt actgcgctct gagaagactt gcgtgcgcca ccacgcgtcg attgacgtct 8700 tgtatctgac gtctctgggt gaaagctacc ggccccgtga gcttgaacct gaaagagagt 8760 tcaacagaat caatttcggt atcgttaacg gcagcttgtc tcagtatttc ttgtacgtca 8820 ccagagttgt cctggtaggc gatctccgcc atgaactgct cgatttcttc ctcctgaaga 8880 tctccgcgac ccgctctctc gacggtggcc gcgaggtcat tggagatacg gcccatgagt 8940 tgggagaatg cagtcatgcc cgcctcgttc cagacgcggc tgtaaaccac ggccccctcg 9000 gagtctcttg cgcgcatcac cacctgagcg aggttaagct ccacgtgtct ggtgaagacc 9060 gcatagttgc ataggcgctg aaaaaggtag ttgagtgtgg tggcaatgtg ttcggcgacg 9120 aagaaataca tgatccatcg tctcagcggc atttcgctga catcgcccag agcttccaag 9180 cgctccatgg cctcgtagaa gtccacggca aaattaaaaa actgggagtt tcgcgcggac 9240 acggtcaatt cctcctcgag aagacggatg agttcggcta tggtggcccg tacttcgcgt 9300 tcgaaggctc ccgggatctc ttcttcctct tctatctctt cttccactaa catctcttct 9360 tcgtcttcag gcgggggcgg agggggcaca cggcgacgtc gacggcgcac gggcaaacgg 9420 tcgatgaatc gttcaatgac ctctccgcgg cggcggcgca tggtttcagt gacggcgcgg 9480 ccgttctcgc gcggtcgcag agtaaaaaca ccgccgcgca tctccttaaa gtggtgactg 9540 ggaggttctc cgtttgggag ggagagggcg ctgattatac attttattaa ttggcccgta 9600 gggactgcgc gcagagatct gatcgtgtca agatccacgg gatctgaaaa cctttcgacg 9660 aaagcgtcta accagtcaca gtcacaaggt aggctgagta cggcttcttg tgggcggggg 9720 tggttatgtg ttcggtctgg gtcttctgtt tcttcttcat ctcgggaagg tgagacgatg 9780 ctgctggtga tgaaattaaa gtaggcagtt ctaagacggc ggatggtggc gaggagcacc 9840 aggtctttgg gtccggcttg ctggatacgc aggcgattgg ccattcccca agcattatcc 9900 tgacatctag caagatcttt gtagtagtct tgcatgagcc gttctacggg cacttcttcc 9960 tcacccgttc tgccatgcat acgtgtgagt ccaaacccgc gcattggttg taccagtgcc 10020 aagtcagcta cgactctttc ggcgaggatg gcttgctgta cttgggtgag ggtggcttga 10080 aagtcatcaa aatccacaaa gcggtggtaa gccccggtat taatggtgta agcacagttg 10140 gccatgactg accagttaac tgtctggtga ccagggcgca cgagctcggt gtatttaagg 10200 cgcgaatagg cgcgggtgtc aaagatgtaa tcgttgcagg tgcgcaccag atactggtaa 10260 cctataagaa aatgcggcgg tggttggcgg tagagaggcc atcgttctgt agctggagcg 10320 ccgggggcga ggtcttccaa cataaggcgg tgatagccgt agatgtacct ggacatccag 10380 gtgattcctg cggcggtagt agaagcccga ggaaactcgc gtacgcggtt ccaaatgttg 10440 cgtagcggca tgaagtagtt cattgtaggc acggtttgac cagtgaggcg cgcgcagtca 10500 ttgatgctct atagacacgg agaaaatgaa agcgttcagc gactcgactc cgtagcctgg 10560 aggaacgtga acgggttggg tcgcggtgta ccccggttcg agacttgtac tcgagccggc 10620 cggagccgcg gctaacgtgg tattggcact cccgtctcga cccagcctac aaaaatccag 10680 gatacggaat cgagtcgttt tgctggttgc cgaatggcag ggaagtgagt cctatttttt 10740 ttttttgccg ctcagatgca tcccgtgctg cgacagatgc gtccccaaca acagcccccc 10800 tcgcagcagc agcaaccaca aaaggctgtc cctgcaacta ctgcaactgc cgctgtgagc 10860 ggtgcgggac agcccgccta tgatctggac ttggaagagg gcgaaggact ggcacgtcta 10920 ggtgcgcctt cgcccgagcg gcatccgcga gttcaactga aaaaagattc tcgcgaggcg 10980 tatgtgcccc aacagaacct atttagagac agaagcggcg aggagccgga ggagatgcga 11040 gcttcccgct ttaacgcggg tcgtgagctg cgtcacggtt tggacagaag acgagtgttg 11100 cgggacgagg atttcgaagt tgatgaagtg acagggatca gtcctgccag ggcacacgtg 11160 gctgcagcca accttgtatc ggcttacgaa cagacagtaa aggaagagcg taatttccaa 11220 aagtctttta ataatcatgt gcgaaccctc attgcccgcg aagaagtcac ccttggtttg 11280 atgcatttgt gggatttgat ggaagctatc attcagaacc ctactagcaa acctctgacc 11340 gcacagctgt ttctggtggt gcaacacagc agagacaatg aggctttcag agaggcgctg 11400 ctcaacatca ccgaacccga ggggagatgg ttgtatgatc ttatcaacat tctacagagt 11460 atcatagtgc aggagcggag cctgggcctg gccgagaagg tggctgccat caattactcg 11520 gttttgagct tgggaaagta ttacgctcgc aagatctaca agactccata cgttcccata 11580 gacaaggagg tgaagataga tgggttctac atgcgcatga cgctgaaggt gttgaccctg 11640 agcgatgatc ttggggtgta ccgcaatgac agaatgcatc gcgcggtgag cgccagcagg 11700 aggcgcgagt taagcgacag ggaactgatg cacagtttgc aaagagctct aactggagct 11760 ggaaccgagg gtgagaatta ctttgatatg ggagctgact tgcagtggca gcctagtcgc 11820 agggctctga acgccgcgac ggcaggatgt gagcttcctt acatagaaga ggcggatgaa 11880 ggcgaggagg aagagggcga gtacttggaa gactgatggc acaacccgtg ttttttgcta 11940 gatggaacag caagcaccgg atcccgcaat gcgggcggcg ctgcagagcc agccgtccgg 12000 cattaactcc tcggacgatt ggacccaggc catgcaacgt atcatggcgt tgacgactcg 12060 caaccccgaa gcctttagac agcaacccca ggccaaccgt ctatcggcca tcatggaagc 12120 tgtagtgcct tcccgctcta atcccactca tgagaaggtc ctggccatcg tgaacgcgtt 12180 ggtggagaac aaagctattc gtccagatga ggccggactg gtatacaacg ctctcttaga 12240 acgcgtggct cgctacaaca gtagcaatgt gcaaaccaat ttggaccgta tgataacaga 12300 tgtacgcgaa gccgtgtctc agcgcgaaag gttccagcgc gatgccaacc tgggttcgct 12360 ggtggcgtta aatgctttct tgagtactca gcctgctaat gtgccgcgtg gtcaacagga 12420 ttatactaac tttttaagtg ctttgagact gatggtatca gaagtacctc agagcgaagt 12480 atatcagtcc ggtcctgatt acttctttca gactagcaga cagggcttgc agacggtaaa 12540 tctgagccaa gcttttaaaa accttaaagg tttgtgggga gtgcatgccc cggtaggaga 12600 aagagcaacc gtgtctagct tgttaactcc gaactcccgc ctattattac tgttggtagc 12660 tcctttcacc gacagcggta gcatcgaccg taattcctat ttgggttacc tactaaacct 12720 gtatcgcgaa gccatagggc aaagtcaggt ggacgagcag acctatcaag aaattaccca 12780 agtcagtcgc gctttgggac aggaagacac tggcagtttg gaagccactc tgaacttctt 12840 gcttaccaat cggtctcaaa agatccctcc tcaatatgct cttactgcgg aggaggagag 12900 gatccttaga tatgtgcagc agagcgtggg attgtttctg atgcaagagg gggcaactcc 12960 gactgcagca ctggacatga cagcgcgaaa tatggagccc agcatgtatg ccagtaaccg 13020 acctttcatt aacaaactgc tggactactt gcacagagct gccgctatga actctgatta 13080 tttcaccaat gccatcttaa acccgcactg gctgccccca cctggtttct acacgggcga 13140 atatgacatg cccgacccta atgacggatt tctgtgggac gacgtggaca gcgatgtttt 13200 ttcacctctt tctgatcatc gcacgtggaa aaaggaaggc ggcgatagaa tgcattcttc 13260 tgcatcgctg tccggggtca ttggtgctac cgcggctgag cccgagtctg caagtccttt 13320 tcctagtcta cccttttctc tacacagtgt acgtagcagc gaagtgggta gaataagtcg 13380 cccgagttta atgggcgaag aggagtacct aaacgattcc ttgctcagac cggcaagaga 13440 aaaaaatttc ccaaacaatg gaatagaaag tttggtggat aaaatgagta gatggaagac 13500 ttatgctcag gatcacagag acgagcctgg gatcatgggg actacaagta gagcgagccg 13560 tagacgccag cgccatgaca gacagagggg tcttgtgtgg gacgatgagg attcggccga 13620 tgatagcagc gtattggact tgggtgggag aggaaggggc aacccgtttg ctcatttgcg 13680 ccctcgcttg ggtggtatgt tgtaaaaaaa aataaaaaag aaaaaactca ccaaggccat 13740 ggcgacgagc gtacgttcgt tcttctttat tatctgtgtc tagtataatg aggcgagtcg 13800 tgctaggcgg agcggtggtg tatccggagg gtcctcctcc ttcgtacgag agcgtgatgc 13860 agcagcagca ggcgacggcg gtgatgcaat ccccactgga ggctcccttt gtgcctccgc 13920 gatacctggc acctacggag ggcagaaaca gcattcgtta ctcggaactg gcacctcagt 13980 acgataccac caggttgtat ctggtggaca acaagtcggc ggacattgct tctctgaact 14040 atcagaatga ccacagcaac ttcttgacca cggtggtgca aaacaatgac tttaccccta 14100 cggaagccag cacccagacc attaactttg atgaacgatc gcggtggggc ggtcagctaa 14160 aaaccatcat gcatactaac atgcccaacg tgaacgagta tatgtttagt aacaagttca 14220 aagcgcgtgt gatggtgtcc agaaaacctc ctgagggtgt tagagtagac gataattatg 14280 atcataagca agatattcta aaatacgagt ggttcgagtt tactttgcca gaaggcaact 14340 tttcggtcac tatgactatc gacttgatga acaatgccat catagacaat tacttgaaag 14400 tgggcagaca gaatggagtg ttggaaagtg acattggtgt taagttcgac actaggaact 14460 tcaagttggg atgggatcca gaaactaagt tgatcatgcc tggggtttac acctatgagg 14520 ccttccatcc tgacatcgta ttgctgcctg gctgcggagt ggactttacc gaaagccgtc 14580 tgagcaacct tcttggcatt agaaagaaac acccattcca agagggtttt aagatcttgt 14640 atgaggattt agaaggagga aatattccag cccttttgga tgtagatgct tatgagaaca 14700 gcaagaaaga tcaaaaagcc aaaatagaag ctgctgcaga agctaaagca aacatagttg 14760 ccaacgatcc ggtaagggtg gctaacgcta gtgaaatcag gggagacagt tttgccgcaa 14820 catccgttcc gactaaagaa tcattattgg atgatgtgtc tcaaaacata gagttaaaac 14880 tcactattaa gcctgtggaa aaagatggca aaaacagaag ttacaatgtg ttggaagata 14940 aaatcaacac ggcctatcgc agttggtacc tttcgtacaa ttatggcgac cccgaaaaag 15000 gagtgcgttc ctggacattg ctcaccacct cagatgtcac ctgcggagcg gagcaggtct 15060 actggtcgct tccagacatg atgcaggatc ctgtcacttt ccgctccact agacaagtca 15120 gtaactaccc tgtggtgggt gcagagctta tgcccgtctt ttcaaagagc ttctacaacg 15180 aacaagctgt gtactcccag cagctccgcc agtccacctc gcttacgcac gtcttcaacc 15240 gctttcctga gaaccagatt ttaatccgtc cgccggcgcc cacaattacc accgtcagtg 15300 aaaacgttcc tgctctcaca gatcacggga ccctgccgtt gcgcagcagt atccggggag 15360 tccaacgtgt gaccgttact gacgccagac gccgcacctg tccctacgtg tacaaggcac 15420 tgggcatagt cgcaccgcgc gtcctttcaa gccgcacttt ctaaaaaaaa aaaaaaaatg 15480 tccgttctta tctcgcccag taataacacc ggttggggtc tgcgcgctcc cagcaagatg 15540 tacggaggcg cacgcaaacg ttctacccaa catcccgtgc gtgttcgcgg gcattttcgc 15600 gctccatggg gtgccctcaa gggccgcact cgcgttcgaa ccaccgtcga tgatgtaatc 15660 gatcaggtgg ttgccgacgc ccgtaattat actcctactg cgcctacatc tactgtggac 15720 gcagttattg acagtgtagt ggctgacgct cgcaactatg ctcgacgtaa gagccggcga 15780 aggcgcattg ccagacgtca ccgagctacc actgccatgc gagcagcaag agctctgcta 15840 cgaagagcta gacgcgtggg gcgaagagcc atgcttaggg cggccagacg tgcagcttcg 15900 ggcgccagcg ccggcaggtc ccgcaggcaa gcagccgctg tcgcagcggc gactattgcc 15960 gacatggccc aatcgcgaag aggcaatgta tactgggtgc gtgacgctgc caccggtcaa 16020 cgtgtacccg tgcgcacccg tccccctcgc acttagaaga tactgagcag tctccgatgt 16080 tgtgtcccag cggcgaggat gtccaagcgc aaatacaagg aagaaatgct gcaggttatc 16140 gcacctgaag tctacggcca accgttgaag gatgaaaaaa aaccccgcaa aatcaagcgg 16200 gtaaaaaagg acaaaaaaga agaggaagat ggcgatgatg ggctggcgga gtttgtgcgc 16260 gagtttgccc cacggcgacg cgtgcaatgg cgtgggcgca aagttcgaca tgtgttgaga 16320 cctggaactt cggtggtctt tacacccggc gagcgttcaa gcgctacttt taagcgttcc 16380 tatgatgagg tgtacgggga tgatgatatt cttgagcagg cagctgaccg attaggcgag 16440 tttgcttatg gcaagcgtag tagaataaat cccaaggatg aaacagtgtc catacccttg 16500 gatcatggaa atcccacccc tagtcttaaa ccggtcactt tgcagcaagt gttacccgta 16560 actccgcgaa caggtgttaa acgcgaaggt gaagatttgt atcccactat gcaactgatg 16620 gtgcccaaac gccagaagtt ggaggacgtt ttggagaaag taaaagtgga tccagatatt 16680 caacctgagg ttaaagtgag acccattaag caggtagcgc ctggtctggg agtacaaact 16740 gtagacatta aaattcccac tgaaagtatg gaagtgcaaa ctgaacccgc aaagcctact 16800 gccacctcca ctgaagtgca aacggaccca tggatgccca tgcctattac aactgacgcc 16860 gtcggtccca ctcgaagatc ccgacgaaag tacggtccag caagtctgtt gatgcccaac 16920 tatgtcgtac acccatctat tattcctact cctggttacc gaggcactcg ctactatcgc 16980 agccgaaaca gtacttcccg ccgtcgccgc aagacacctg caaatcgcag tcgtcgccgt 17040 agacgcacaa gcaaaccgat tcccggcgcc ctggtgcggc aagtgtaccg caatggtagt 17100 gcggaacctt tgacactgcc gcgtgcgcgt taccatccta gtatcatcac ttaatcaatg 17160 ttgccgctgc ctccttgcag atatggccct cacttgtcgc cttcgcgttc ccatcactgg 17220 ttaccgagga agaaactcgc gccgtagaag agggatgttg gggcgcggaa tgcgacgcta 17280 caggcgacgg cgtgctatcc gcaagcaatt gcggggtggt tttttgccag ccttaattcc 17340 aattatcgct gctgcgattg gcgcaatacc aggcatagct tccgtggcgg ttcaggcctc 17400 gcaacgacat tgacattgga aaaaaaaaaa acgtataaat aaaaaataca atggactctg 17460 acactcctgg tactgtgact atgttttctt agagatggaa gacatcaatt tttcatcctt 17520 ggctccgcga cacggcacga agccgtacat gggcacctgg agcgacatcg gcacgagcca 17580 actgaacggg ggcgccttca attggagcag tatctggagc gggcttaaaa attttggctc 17640 aaccataaaa acatacggga acaaagcttg gaacagcagt acaggacagg cgcttagaaa 17700 taaacttaaa gaccagaact tccaacaaaa agtagtcgat gggatagctt ccggtatcaa 17760 tggagtggta gatttggcta accaggctgt gcagaaaaag ataaacagtc gtttggaccc 17820 gccgccagca accccaggtg aaatgcaagt ggaggaagaa attcctccgc cagaaaaacg 17880 aggcgacaag cgtccgcgtc ccgatttgga agagacgctg gtgacgcgcg tagatgaacc 17940 gccttcttat gaggaagcaa cgaagcttgg aatgcccacc actagaccga tagcccctat 18000 ggccaccggg gtgatgaaac cttctcagtt gcatcgaccc gtcaccttgg atttgccccc 18060 tcctcctgct gctactgctg tacccgcttc taagcctgtc gctgccccga aaccagtcgc 18120 cgtagccagg tcacgtcccg ggggcgctcc tcgtccaaat gcacactggc aaaatactct 18180 gaacagcatc gtgggtctag gcgtgcaaag tgtaaaacgc cgtcgctgct tttaattaaa 18240 tatggagtag cgcttaactt gcctatctgt gtatatgtgt cattacacgc cgtcacagca 18300 tcagaggaaa aaaggaagag gtcgtgcgtc gacgctgagt tactttcaag atggccaccc 18360 catcgatgct gccccaatgg gcatacatgc acatcgccgg acaggatgct tcggagtacc 18420 tgagtccggg tctggtgcag ttcgcccgcg ccacagacac ctacttcaat ctgggaaata 18480 agtttagaaa tcctaccgta gcgccgaccc acgatgtgac caccgatcgt agccagcggc 18540 tcatgttgcg cttcgtgccc gttgaccggg aggacaatac atactcttac aaagtgcggt 18600 acaccctggc cgtgggcgac aacagagtgc tggatatggc cagcacgttc tttgacatta 18660 ggggcgtgtt ggacagaggt cccagtttta aaccctattc tggtacggct tacaactccc 18720 tggctcctaa aggcgctcca aatgcatctc agtggttgga taagggagtt acaagcactg 18780 gcctagtgga cgacggcaat actgatgatg gggaagaagc caaaaaagca acatacactt 18840 ttggtaatgc tccagtaaaa gccgaggctg aaatcacaaa agacggattg ccggtgggct 18900 tggaagtttc aactgaaggt cctaaaccaa tctatgctga taagctttat cagccagaac 18960 ctcaagtggg agacgaaact tggactgacc tagacggaaa aaccgaagag tatggaggga 19020 gggttcttaa acctgaaact aaaatgaaac cctgctacgg atcttttgct aaacctacta 19080 atattaaagg aggtcaggca aaggtaaaac caaaagaaga cgatggcact aacaacatcg 19140 agtatgacat tgacatgaac ttctttgact taagatcaca aagatcagaa ctcaaaccta 19200 aaattgtaat gtatgcagaa aatgtggacc tggaatgtcc agatactcat gttgtgtaca 19260 aacctggagt ttcagatgct agttctgaga ccaatcttgg acaacagtct atgcccaaca 19320 gacccaacta cattggcttc agagataact tcatcggact tatgtactat aacagtactg 19380 gcaacatggg ggtactggct ggccaagcgt ctcagttgaa tgcagtggtt gacttgcagg 19440 acagaaacac agaactgtct taccaactct tgcttgactc tctgggcgac agaaccagat 19500 actttagcat gtggaatcag gctgtggaca gttatgatcc tgatgtacgt gttattgaaa 19560 atcatggtgt ggaagatgaa cttcccaact attgttttcc gttggatggt gtcggtccgc 19620 gaacagatag ttacaaggag attaagccaa atggagacca atctacttgg acaaatgtag 19680 acccaactgg cagcagtgaa cttgctaagg gaaatccatt tgccatggaa attaaccttc 19740 aagccaatct atggcgaagt ttcctttatt ccaatgtggc tctatatctc ccagactcgt 19800 acaaatacac cccgtccaat gtcactcttc cagaaaacaa aaacacctac gactacatga 19860 acgggcgggt ggtgccgcca tctctagtag acacctatgt gaacattggt gccaggtggt 19920 ctctggatgc catggacaat gtcaacccat tcaaccacca ccgtaacgct ggcttgcgtt 19980 accgatccat gcttctgggt aacggacgtt atgtgccttt ccacatacaa gtgcctcaaa 20040 aattcttcgc tgttaaaaac ctgctgcttc tcccaggctc ctacacttat gagtggaact 20100 ttaggaagga tgtaaacatg gttctacaga gttccctcgg taacgaccta cgggtagatg 20160 gcgccagcat cagttttacg agcatcaacc tctatgctac ttttttcccc atggctcaca 20220 acaccgcttc cacccttgaa gccatgctgc ggaatgacac caatgatcag tcattcaacg 20280 actacctatc tgcagctaac atgctctacc ccattcctgc caatgcaacc aatattccca 20340 tttccattcc ttctcgcaac tgggcggctt tcagaggctg gtcatttacc agactgaaaa 20400 ccaaagaaac tccctctttg gggtctggat ttgaccccta cttcgtctat tctggttcta 20460 ttccctacct ggatggtacc ttctacctga accacacttt taagaaggtt tccatcatgt 20520 ttgactcttc agtgagctgg cctggaaatg acaggttact atctcctaac gaatttgaaa 20580 taaagcgcac tgtggatggc gaaggctaca acgtagccca atgcaacatg accaaagact 20640 ggttcttggt acagatgctc gccaactaca acatcggcta tcagggcttc tacattccag 20700 aaggatacaa agatcgcatg tattcatttt tcagaaactt ccagcccatg agcaggcagg 20760 tggttgatga ggtcaattac aaagacttca aggccgtcgc cataccctac caacacaaca 20820 actctggctt tgtgggttac atggctccga ccatgcgtca aggtcaaccc tatcccgcta 20880 actatcccta tccactcatt ggaacaactg ccgtaaatag tgttacgcag aaaaagttct 20940 tgtgtgacag aaccatgtgg cgcataccgt tctcaagcaa cttcatgtct atgggagccc 21000 ttacagactt gggacagaac atgctctatg ccaactcagc tcatgctctg gacatgacct 21060 ttgaggtgga tcccatggat gagcccaccc tgctttatct tctcttcgaa gttttcgacg 21120 tggtcagagt gcatcagcca caccgcggca tcatcgaggc agtctacctg cgtacaccgt 21180 tctcggccgg taacgctacc acgtaagaag cttcttgctt cttgcaaaca gcagctgcaa 21240 ccatggcctg cggatcccaa aacggctcca gcgagcaaga gctcagagcc attgtccaag 21300 acctgggttg cggaccatat tttttgggaa cctttgataa gcgcttcccg gggttcatgg 21360 cccccgataa gctcgcctgt gccattgtaa atacggccgg acgtgagacg gggggagagc 21420 actggttggc tttcggttgg aacccacgtt ctaacacctg ctaccttttt gatccttttg 21480 gattctcgga tgatcgtctc aaacagattt accagtttga atatgagggt ctcctgcgcc 21540 gcagcgctct tgctaccaag gaccggtgta ttacgctgga aaaatctacc cagaccgtgc 21600 agggcccccg ttctgccgcc tgcggacttt tctgctgcat gttccttcat gcctttgtgc 21660 actggcctga ccgtcccatg gacggaaacc ccaccatgaa attgctaact ggagtgccaa 21720 acaacatgct tcattctcct aaagtccagc ccaccctgtg tgacaatcaa aaagcactct 21780 accattttct caatacccat tcgccttatt ttcgctctca tcgtacacac atcgaaaggg 21840 ccactgcgtt cgaccgtatg gatgtgcaat aatgattcat gtaaacaacg tgttcaataa 21900 acagcacttt attttttaca tgtatcgagg ctctggatta cttatttatt tacaagtcga 21960 atgggttctg acgagaatca gaatgacccg caggcagtga tacgttgcgg aactgatact 22020 tgggttgcca cttgaattcg ggaatcacca acttgggaac cggtatatcg ggcaggatgt 22080 cactccacag ctttctggtc agctgcaaag ctcccagcag gtcaggagcc gaaatcttga 22140 aatcacaatt aggaccagtg ctctgagcgc gagagttgcg gtacaccgga ttgcagcact 22200 gaaacaccat cagcgacgga tgtcttacgc ttgccagcac ggtgggatct gcaatcatgc 22260 ccacatccag atcttcagca ttggcaatgc tgaacggggt catcttgcag gtctgcctac 22320 ccatggcggg cacccaatta ggcttgtggt tacaatcgca gtgcaggggg atcagtatca 22380 tcttggcctg atcctgtctg attcctggat acacggctct catgaaagca tcatattgct 22440 tgaaagcctg ctgggcttta ctaccctcgg tataaaacat cccgcaggac ctgctcgaaa 22500 actggttagc tgcgcagccg gcatcattca cacagcagcg ggcgtcattg ttggctattt 22560 gcaccacact tctgccccag cggttttggg tgattttggt tcgctcggga ttctccttca 22620 aggctcgttg tccgttctcg ctggccacat ccatctcgat aatctgctcc ttctgaatca 22680 taatattgcc atgcaagcac ttcagcttgc cctcataatc attgcagcca tgaggccaca 22740 acgcacagcc tgtacattcc caattatggt gggcgatctg agaaaaagaa tgtatcattc 22800 cctgcagaaa tcttcccatc atcgtgctca gtgtcttgtg actagtgaaa gttaactgga 22860 tgcctcggtg ctcctcgttc acgtactggt gacagatgcg cttgtattgt tcgtgctgct 22920 caggcattag tttaaaagag gttctaagtt cgttatccag cctgtacttc tccatcagca 22980 gacacatcac ttccatgcct ttctcccaag cagacaccag gggcaagcta atcggattct 23040 taacagtgca ggcagcagct cctttagcca gagggtcatc tttggcgatc ttctcaatgc 23100 ttcttttgcc atccttctca acgatgcgca cgggcgggta gctgaaaccc actgctacaa 23160 gttgcgcctc ttctctttct tcttcgctgt cttgactgat gtcttgcatg gggacatgtt 23220 tggtcttcct tggcttcttt ttcgggggta tcggaggagg aggactgtcg ctccgttccg 23280 gagacaggga ggattgtgac gtttcgctca ccattaccaa ctgactgtcg gtagaagaac 23340 ctgaccccac acggcgacag gtgtttctct tcgggggcag aggtggaggc gattgcgaag 23400 ggctgcggtc cgacctggaa ggcggatgac tggcagaacc ccttccgcgt tcgggggtgt 23460 gctccctgtg gcggtcgctt aactgatttc cttcgcggct ggccattgtg ttctcctagg 23520 cagagaaaca acagacatgg aaactcagcc attgctgtca acatcgccac gagtgccatc 23580 acatctcgtc ctcagcgacg aggaaaagga gcagagctta agcattccac cgcccagtcc 23640 tgccaccacc tctaccctag aagataagga ggtcgacgca tctcatgaca tgcagaataa 23700 aaaagcgaaa gagtctgagc cagacatcga acaagacccg ggctatgtga caccggtgga 23760 acacgaggaa gagttgaaac gctttctaga gagagaggat gaaaactgcc caaaacagca 23820 agcggataac tatcaccaag atgctggaaa tagggatcag aacaccgact acctcatagg 23880 gcttgacggg gaagacgcgc tccttaaaca tctagcaaga cagtcactca tagtcaagga 23940 tgcattattg gacagaactg aagtgcccat cagtgtcgaa gagctcagcc gcgcctacga 24000 gcttaaccta ttttcacctc gtactccccc caaacgtcag ccaaacggca cctgcgagcc 24060 aaatcctcgc ttaaactttt atccagcttt tgctgtgcca gaagtactgg ctacctatca 24120 catctttttt aaaaatcaaa aaattccagt ctcctgccgc gctaatcgca cccgcgccga 24180 tgccctactc aatctgggac ctggttcacg cttacctgat atagcttcct tggaagaggt 24240 tccaaagatc ttcgagggtc tgggcaataa tgagactcgg gccgcaaatg ctctgcaaaa 24300 gggagaaaat ggcatggatg agcatcacag cgttctggtg gaattggaag gcgataatgc 24360 cagactcgca gtactcaagc gaagcgtcga ggtcacacac tttgcatacc ccgctgtcaa 24420 cctgccccct aaagtcatga cggccgtcat ggaccagtta ctcattaagc gcgcaagtcc 24480 cctttcagaa gacatgcatg acccagatgc ctgtgatgag ggtaaaccag tggtcagtga 24540 tgagcagcta acccgatggc tgggcaccga ctctccccgg gatttggaag agcgtcgcaa 24600 gcttatgatg gccgtggtgc tggttaccgt agaactagag tgtcttcggc gtttctttac 24660 cgattcagaa accttgcgca aactcgaaga gaatctgcac tacactttta gacacggctt 24720 tgtgcggcag gcatgcaaga tatctaacgt ggaactcacc aacctggttt cctacatggg 24780 tattctgcat gagaatcgcc taggacaaag cgtgctgcac agcaccctta agggggaagc 24840 ccgccgtgat tacatccgcg attgtgttta tctctacctg tgccacacgt ggcaaaccgg 24900 catgggtgta tggcagcaat gtttagaaga acagaacctg aaagagctaa acaagctctt 24960 acagaaatct cttaaggttc tgtggacagg gttcgacgag cgcaccgtcg cttccgacct 25020 ggcagacctc atcttcccag agcgtctcag ggttactttg cgaaacggac tgcctgactt 25080 tatgagccag agcatgctta acaattttcg ctctttcatc ctggaacgct ccggtatcct 25140 gcccgccacc tgctgcgcac tgccctccga ctttgtgcct ctcacctacc gcgaatgccc 25200 cccgccgcta tggagtcact gctacctgtt ccgtctggcc aactacctct cctaccactc 25260 ggatgtgatc gaggatgtga gcggagacgg cttgctggag tgtcactgcc gctgcaatct 25320 gtgcacgccc caccggtccc tagcttgcaa cccccagttg atgagcgaaa cccagataat 25380 aggcaccttt gaattgcaag gccccagcag ccaaggcgat gggtcttctc ctgggcaaag 25440 tttaaaactg accccgggac tgtggacctc cgcctacttg cgcaagtttg ccccggaaga 25500 ttaccacccc tatgaaatca agttctatga ggaccaatca cagcctccga aagccgaact 25560 ttcggcctgc gtcatcaccc agggggcaat tctggcccaa ttgcaagcca tccaaaaatc 25620 ccgccaagaa tttctactga aaaagggtaa gggggtctac cttgaccccc agaccggcga 25680 ggaactcaac acaaggttcc ctcaggatgt cccaacgacg agaaagcaag aagttgaagg 25740 tgcagccgcc gcccccagaa gatatggagg aagattggga cagtcaggca gaggaagcgg 25800 aggaggagga cagtctggag gacagtctgg aggaagacag tttggaggag gaaaacgagg 25860 aggcagagga ggtggaagaa gtaaccgccg acaaacagtt atcctcggct gcggagacaa 25920 gcaacagcgc taccatctcc gctccgagtc gaggaacccg gcggcgtccc agcagtagat 25980 gggacgagac cggacgcttc ccgaacccaa ccagcgcttc caagaccggt aagaaggatc 26040 ggcagggata caagtcctgg cgggggcata agaatgccat catctcctgc ttgcatgagt 26100 gcgggggcaa catatccttc acgcggcgct acttgctatt ccaccatggg gtgaactttc 26160 cgcgcaatgt tttgcattac taccgtcacc tccacagccc ctactatagc cagcaaatcc 26220 cggcagtctc gacagataaa gacagcggcg gcgacctcca acagaaaacc agcagcggca 26280 gttagaaaat acacaacaag tgcagcaaca ggaggattaa agattacagc caacgagcca 26340 gcgcaaaccc gagagttaag aaatcggatc tttccaaccc tgtatgccat cttccagcag 26400 agtcggggcc aagagcagga actgaaaata aaaaaccgat ctctgcgttc gctcaccaga 26460 agttgtttgt atcacaagag cgaagatcaa cttcagcgca ctctcgagga cgccgaggct 26520 ctcttcaaca agtactgcgc gctgactctt aaagagtagg cagcgaccgc gcttattcaa 26580 aaaaggcggg aattacatca tcctcgacat gagtaaagaa attcccacgc cttacatgtg 26640 gagttatcag ccccaaatgg gattggcggc aggcgcctcc caggactact ccacccgcat 26700 gaattggctc agcgccgggc cttctatgat ttctcgagtt aatgatatac gcgcctaccg 26760 aaaccaaata cttttggaac agtcagctct taccaccacg ccccgccaac accttaatcc 26820 cagaaattgg cccgccgccc tagtgtacca ggaaagtccc gctcccacca ctgtattact 26880 tcctcgagac gcccaggccg aagtccaaat gactaatgca ggtgcgcagt tagcgggcgg 26940 ctccacccta tgtcgtcaca ggcctcggca taatataaaa cgcctgatga tcagaggccg 27000 aggtatccag ctcaacgacg agtcggtgag ctctccgctt ggtctacgac cagacggaat 27060 ctttcagatt gccggctgcg ggagatcttc cttcacccct cgtcaggctg ttctgacttt 27120 ggaaagttcg tcttcgcaac cccgctcggg cggaatcggg accgttcaat ttgtggagga 27180 gtttactccc tctgtctact tcaacccctt ctccggatct cctgggcact acccggacga 27240 gttcataccg aacttcgacg cgattagcga gtcagtggac ggctacgatt gagtttatgt 27300 taagtggaga ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc cgccacaagt 27360 gctttgcccg cgactccggt gagttttgct actttgaatt gcccgaggat catatcgagg 27420 gcccggcgca cggcgtccgg cttaccgccc agggagagct tgcccgtagc ctgattcggg 27480 agtttaccca gcgccccctg ctagttgagc gggacagggg accctgtgtt ctcactgtga 27540 tttgcaactg tcctaaccct ggattacatc aagatctttg ttgccatctc tgtgctgagt 27600 ataataaata cagaaattaa aatatactgg ggctcctatc gccatcctgt aaacgccacc 27660 gtcttcaccc gcccaagcaa accaaggcga accttacctg gtacttttaa catctctccc 27720 tctgtgattt acaacagttt caacccagac ggagtgagtc tacgagagaa cctctccgag 27780 ctcagctact ccatcagaaa aaacaccacc ctccttacct gccgggaacg tacgagtgcg 27840 tcaccggccg ctgcaccaca cctaccgcct gaccgtaaac cagacttttt ccggacagac 27900 ctcaataact ctgtttacca gaacaggagg tgagcttaga aaacccttag ggtattaggc 27960 caaaggcgca gctactgtgg ggtttatgaa caattcaagc aactctacgg gctattctaa 28020 ttcaggtttc tctagaatcg gggttggggt tattctctgt cttgtgattc tctttattct 28080 tatactaacg cttctctgcc taaggctcgc cgcctgctgt gtgcacattt gcatttattg 28140 tcagcttttt aaacgctggg gtcgccaccc aagatgatta ggtacataat cctaggttta 28200 ctcacccttg cgtcagccca cggtaccacc caaaaggtgg attttaagga gccagcctgt 28260 aatgttacat tcgcagctga agctaatgag tgcaccactc ttataaaatg caccacagaa 28320 catgaaaagc tgcttattcg ccacaaaaac aaaattggca agtatgctgt ttatgctatt 28380 tggcagccag gtgacactac agagtataat gttacagttt tccagggtaa aagtcataaa 28440 acttttatgt atacttttcc attttatgaa atgtgcgaca ttaccatgta catgagcaaa 28500 cagtataagt tgtggccccc acaaaattgt gtggaaaaca ctggcacttt ctgctgcact 28560 gctatgctaa ttacagtgct cgctttggtc tgtaccctac tctatattaa atacaaaagc 28620 agacgcagct ttattgagga aaagaaaatg ccttaattta ctaagttaca aagctaatgt 28680 caccactaac tgctttactc gctgcttgca aaacaaattc aaaaagttag cattataatt 28740 agaataggat ttaaaccccc cggtcatttc ctgctcaata ccattcccct gaacaattga 28800 ctctatgtgg gatatgctcc agcgctacaa ccttgaagtc aggcttcctg gatgtcagca 28860 tctgactttg gccagcacct gtcccgcgga tttgttccag tccaactaca gcgacccacc 28920 ctaacagaga tgaccaacac aaccaacgcg gccgccgcta ccggacttac atctaccaca 28980 aatacacccc aagtttctgc ctttgtcaat aactgggata acttgggcat gtggtggttc 29040 tccatagcgc ttatgtttgt atgccttatt attatgtggc tcatctgctg cctaaagcgc 29100 aaacgcgccc gaccacccat ctatagtccc atcattgtgc tacacccaaa caatgatgga 29160 atccatagat tggacggact gaaacacatg ttcttttctc ttacagtatg attaaatgag 29220 acatggccgt tcagctggtg gaaagtggcg ggggttctgt tcaggcgggc gggtctctga 29280 ggcttacttg cgccgcgagt ggtagaacca gtcggagcta cggaatgggg tggtttaggc 29340 aagctcccgg gaaagaacgc gaatttgtga gcggcattag ctggcggggc gattccactg 29400 ggtacgcaga ctctgtaaag ggaaggttta ccatcagccg cgataacgca aagaacaccg 29460 ttgatctgca gatgaatagc ttgagaccgg aggacaccgc catctactac tgtgcagctg 29520 ccgccggaag cacatggtat gggactctgt atgaatacga ctactggggc cagggtacac 29580 aagttaccgt aagcagcggc tctgggtccg gctcgaccgg agtgcaggtg gaaaccatct 29640 ccccaggaga cgggcgcacc ttccccaagc gcggccagac ctgcgtggtg cactacaccg 29700 ggatgcttga agatggaaag aaatttgatt cctcccggga cagaaacaag ccctttaagt 29760 ttatgctagg caagcaggag gtgatccgag gctgggaaga aggggttgcc cagatgagtg 29820 tgggtcagag agccaaactg actatatctc cagattatgc ctatggtgcc actgggcacc 29880 caggcatcat cccaccacat gccactctcg tcttcgatgt ggagcttcta aaactgtaat 29940 aaaaaaaaat aataaagctt aatcacttac ttgaaatcag caataaggtc tctgttgaaa 30000 ttttctccca gcagcacctc acttccctct tcccaactct ggtattctaa accccgttca 30060 gcggcatact ttctccatac tttaaagggg atgtcaaatt ttagctcctc tcctgtaccc 30120 acaatcttca tgtctttctt cccagatgac caagagagtc cggctcagtg actccttcaa 30180 ccctgtctac ccctatgaag atgaaagcac ctcccaacac ccctttataa acccagggtt 30240 tatttcccca aatggcttca cacaaagccc agacggagtt ctctctttgc gcctatccga 30300 acctctagtt acctccaatg gcatgcttgc gctcaaaatg ggcaacggcc tctctctgga 30360 cgaggccggc aaccttacct cccaaaatgt aaccactgtg agcccacctc tcaaaaaaac 30420 caagtcaaac ataaacctgg aaatatctgc acccctcaca gttacctcag aagccctaac 30480 tgtggctgcc gccgcacctc taatggtcgc gggcaacaca ctcaccatgc aatcacaggc 30540 cccgctaacc gtgcacgact ccaaacttag cattgccacc caaggacccc tcacagtgtc 30600 agaaggaaag ctagccctgc aaacatcagg ccccctcacc accaccgata gcagtaccct 30660 tactatcact gcctcacccc ctctaactac tgccactggt agcttgggca ttgacttgaa 30720 agagcccatt tatacacaaa atggaaaact aggactaaag tacggggctc ctttgcatgt 30780 aacagacgac ctaaacactt tgaccgtagc aactggtcca ggtgtgacta ttaataatac 30840 ttccttgcaa actaaagtta ctggagcctt gggttttgat tcacaaggca atatgcaact 30900 taatgtagca ggaggactaa ggattgattc tcaaaacaga cgccttatac ttgatgttag 30960 ttatccgttt gatgctcaaa accaactaaa tctaagacta ggacagggcc ctctttttat 31020 aaactcagcc cacaacttgg atattaacta caacaaaggc ctttacttgt ttacagcttc 31080 aaacaattcc aaaaagcttg aggttaacct aagcactgcc aaggggttga tgtttgacgc 31140 tacagccata gccattaatg caggagatgg gcttgaattt ggttcaccta atgcaccaaa 31200 cacaaatccc ctcaaaacaa aaattggcca tggcctagaa tttgattcaa acaaggctat 31260 ggttcctaaa ctaggaactg gccttagttt tgacagcaca ggtgccatta cagtaggaaa 31320 caaaaataat gataagctaa ctttgtggac cacaccagct ccatctccta actgtagact 31380 aaatgcagag aaagatgcta aactcacttt ggtcttaaca aaatgtggca gtcaaatact 31440 tgctacagtt tcagttttgg ctgttaaagg cagtttggct ccaatatctg gaacagttca 31500 aagtgctcat cttattataa gatttgacga aaatggagtg ctactaaaca attccttcct 31560 ggacccagaa tattggaact ttagaaatgg agatcttact gaaggcacag cctatacaaa 31620 cgctgttgga tttatgccta acctatcagc ttatccaaaa tctcacggta aaactgccaa 31680 aagtaacatt gtcagtcaag tttacttaaa cggagacaaa actaaacctg taacactaac 31740 cattacacta aacggtacac aggaaacagg agacacaact gagatgtggc atgaaggcct 31800 agaagaggcc tctcgcttgt actttgggga gaggaacgtc aaaggcatgt ttgaggtgct 31860 ggagcccctg catgctatga tggaacgcgg tccccagacc ctgaaggaaa cgtcctttaa 31920 tcaggcatat ggtcgagatt taatggaggc acaagaatgg tgccgaaagt acatgaaatc 31980 agggaacgtc aaggacctcc tccaagcctg ggacctctac tatcacgtgt tcagacgaat 32040 ctcaaagcag ccaagtgcat actctatgtc attttcatgg gactggtctg gccacaacta 32100 cattaatgaa atatttgcca catcctctta cactttttca tacattgccc aagaataata 32160 aagaatcgtt tgtgttatgt ttcaacgtgt ttatttttca attgcagaaa atttcgaatc 32220 atttttcatt cagtagtata gccccaccac cacatagctt atacagatca ccgtacctta 32280 atcaaaccta catgggggta gagtcataat cgtgcatcag gatagggcgg tggtgctgca 32340 gcagcgcgcg aataaactgc tgccgccgcc gctccgtcct gcaggaatac aacatggcag 32400 tggtctcctc agcgatgatt cgcaccgccc gcagcataag gcgccttgtc ctccgggcac 32460 agcagcgcac cctgatctca cttaaatcag cacagtaact gcagcacagc accacaatat 32520 tgttcaaaat cccacagtgc aaggcgctgt atccaaagct catggcgggg accacagaac 32580 ccacgtggcc atcataccac aagcgcaggt agattaagtg gcgacccctc ataaacacgc 32640 tggacataaa cattacctct tttggcatgt tgtaattcac cacctcccgg taccatataa 32700 acctctgatt aaacatggcg ccatccacca ccatcctaaa ccagctggcc aaaacctgcc 32760 cgccggctat acactgcagg gaaccgggac tggaacaatg acagtggaga gcccaggact 32820 cgtaaccatg gatcatcatg ctcgtcatga tatcaatgtt ggcacaacac aggcacacgt 32880 gcatacactt cctcaggatt acaagctcct cccgcgttag aaccatatcc cagggaacaa 32940 cccattcctg aatcagcgta aatcccacac tgcagggaag acctcgcacg taactcacgt 33000 tgtgcattgt caaagtgtta cattcgggca gcagcggatg atcctccagt atggtagcgc 33060 gggtttctgt ctcaaaagga ggtagacgat ccctactgta cggagtgcgc cgagacaacc 33120 gagatcgtgt tggtcgtagt gtcatgccaa atggaacgcc ggacgtagtc atatttcctg 33180 aagcaaaacc aggtgcgggc gtgacaaaca gatctgcgtc tccggtctcg ccgcttagat 33240 cgctctgtgt agtagttgta gtatatccac tctctcaaag catccaggcg ccccctggct 33300 tcgggttcta tgtaaactcc ttcatgcgcc gctgccctga taacatccac caccgcagaa 33360 taagccacac ccagccaacc tacacattcg ttctgcgagt cacacacggg aggagcggga 33420 agagctggaa gaaccatgtt ttttttttta ttccaaaaga ttatccaaaa cctcaaaatg 33480 aagatctatt aagtgaacgc gctcccctcc ggtggcgtgg tcaaactcta cagccaaaga 33540 acagataatg gcatttgtaa gatgttgcac aatggcttcc aaaaggcaaa cggccctcac 33600 gtccaagtgg acgtaaaggc taaacccttc agggtgaatc tcctctataa acattccagc 33660 accttcaacc atgcccaaat aattctcatc tcgccacctt ctcaatatat ctctaagcaa 33720 atcccgaata ttaagtccgg ccattgtaaa aatctgctcc agagcgccct ccaccttcag 33780 cctcaagcag cgaatcatga ttgcaaaaat tcaggttcct cacagacctg tataagattc 33840 aaaagcggaa cattaacaaa aataccgcga tcccgtaggt cccttcgcag ggccagctga 33900 acataatcgt gcaggtctgc acggaccagc gcggccactt ccccgccagg aaccatgaca 33960 aaagaaccca cactgattat gacacgcata ctcggagcta tgctaaccag cgtagccccg 34020 atgtaagctt gttgcatggg cggcgatata aaatgcaagg tgctgctcaa aaaatcaggc 34080 aaagcctcgc gcaaaaaaga aagcacatcg tagtcatgct catgcagata aaggcaggta 34140 agctccggaa ccaccacaga aaaagacacc atttttctct caaacatgtc tgcgggtttc 34200 tgcataaaca caaaataaaa taacaaaaaa acatttaaac attagaagcc tgtcttacaa 34260 caggaaaaac aacccttata agcataagac ggactacggc catgccggcg tgaccgtaaa 34320 aaaactggtc accgtgatta aaaagcacca ccgacagctc ctcggtcatg tccggagtca 34380 taatgtaaga ctcggtaaac acatcaggtt gattcacatc ggtcagtgct aaaaagcgac 34440 cgaaatagcc cgggggaata catacccgca ggcgtagaga caacattaca gcccccatag 34500 gaggtataac aaaattaata ggagagaaaa acacataaac acctgaaaaa ccctcctgcc 34560 taggcaaaat agcaccctcc cgctccagaa caacatacag cgcttccaca gcggcagcca 34620 taacagtcag ccttaccagt aaaaaagaaa acctattaaa aaaacaccac tcgacacggc 34680 accagctcaa tcagtcacag tgtaaaaaag ggccaagtgc agagcgagta tatataggac 34740 taaaaaatga cgtaacggtt aaagtccaca aaaaacaccc agaaaaccgc acgcgaacct 34800 acgcccagaa acgaaagcca aaaaacccac aacttcctca aatcgtcact tccgttttcc 34860 cacgttacgt cacttcccat tttaagaaaa ctacaattcc caacacatac aagttactcc 34920 gccctaaaac ctacgtcacc cgccccgttc ccacgccccg cgccacgtca caaactccac 34980 cccctcatta tcatattggc ttcaatccaa aataaggtat attattgatg atg 35033 <210> 98 <211> 36674 <212> DNA <213> Artificial Sequence <220> <223> Recombinant adenovirus genome (AdSyn-CO220) <400> 98 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc 600 catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg 660 cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct 720 gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg 780 ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt 840 ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa 900 gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga 960 cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat 1020 ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga 1080 cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt 1140 gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga 1200 gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat 1260 ggacgagctg tacaagggaa gtggacggga gggaatgaga catattatct gccacggagg 1320 tgttattacc gaagaaatgg ccgccagtct tttggaccag ctgatcgaag aggtactggc 1380 tgataatctt ccacctccta gccattttga accacctacc cttcacgaac tgtatgattt 1440 agacgtgacg gcccccgaag atcccaacga ggaggcggtt tcgcagattt ttcccgactc 1500 tgtaatgttg gcggtgcagg aagggattga cttactcact tttccgccgg cgcccggttc 1560 tccggagccg cctcaccttt cccggcagcc cgagcagccg gagcagagag ccttgggtcc 1620 ggtttctatg ccaaaccttg taccggaggt gatcgatctt acctgccacg aggctggctt 1680 tccacccagt gacgacgagg atgaagaggg tgaggagttt gtgttagatt atgtggagca 1740 ccccgggcac ggttgcaggt cttgtcatta tcaccggagg aatacggggg acccagatat 1800 tatgtgttcg ctttgctata tgaggacctg tggcatgttt gtctacagta agtgaaaatt 1860 atgggcagtg ggtgatagag tggtgggttt ggtgtggtaa tttttttttt aatttttaca 1920 gttttgtggt ttaaagaatt ttgtattgtg atttttttaa aaggtcctgt gtctgaacct 1980 gagcctgagc ccgagccaga accggagcct gcaagaccta cccgccgtcc taaaatggcg 2040 cctgctatcc tgagacgccc gacatcacct gtgtctagag aatgcaatag tagtacggat 2100 agctgtgact ccggtccttc taacacacct cctgagatac acccggtggt cccgctgtgc 2160 cccattaaac cagttgccgt gagagttggt gggcgtcgcc aggctgtgga atgtatcgag 2220 gacttgctta acgagcctgg gcaacctttg gacttgagct gtaaacgccc caggccataa 2280 ggtgtaaacc tgtgattgcg tgtgtggtta acgcctttgt ttgctgaatg agttgatgta 2340 agtttaataa agggtgagat aatgtttaac ttgcatggcg tgttaaatgg ggcggggctt 2400 aaagggtata taatgcgccg tgggctaatc ttggttacat ctgacctcat ggaggcttgg 2460 gagtgtttgg aagatttttc tgctgtgcgt aacttgctgg aacagagctc taacagtacc 2520 tcttggtttt ggaggtttct gtggggctca tcccaggcaa agttagtctg cagaattaag 2580 gaggattaca agtgggaatt tgaagagctt ttgaaatcct gtggtgagct gtttgattct 2640 ttgaatctgg gtcaccaggc gcttttccaa gagaaggtca tcaagacttt ggatttttcc 2700 acaccggggc gcgctgcggc tgctgttgct tttttgagtt ttataaagga taaatggagc 2760 gaagaaaccc atctgagcgg ggggtacctg ctggattttc tggccatgca tctgtggaga 2820 gcggttgtga gacacaagaa tcgcctgcta ctgttgtctt ccgtccgccc ggcgataata 2880 ccgacggagg agcagcagca gcagcaggag gaagccaggc ggcggcggca ggagcagagc 2940 ccatggaacc cgagagccgg cctggaccct cgggaatgaa tgttgtacag gtggctgaac 3000 tgtatccaga actgagacgc attttgacaa ttacagagga tgggcagggg ctaaaggggg 3060 taaagaggga gcggggggct tgtgaggcta cagaggaggc taggaatcta gcttttagct 3120 taatgaccag acaccgtcct gagtgtatta cttttcaaca gatcaaggat aattgcgcta 3180 atgagcttga tctgctggcg cagaagtatt ccatagagca gctgaccact tactggctgc 3240 agccagggga tgattttgag gaggctatta gggtatatgc aaaggtggca cttaggccag 3300 attgcaagta caagatcagc aaacttgtaa atatcaggaa ttgttgctac atttctggga 3360 acggggccga ggtggagata gatacggagg atagggtggc ctttagatgt agcatgataa 3420 atatgtggcc gggggtgctt ggcatggacg gggtggttat tatgaatgta aggtttactg 3480 gccccaattt tagcggtacg gttttcctgg ccaataccaa ccttatccta cacggtgtaa 3540 gcttctatgg gtttaacaat acctgtgtgg aagcctggac cgatgtaagg gttcggggct 3600 gtgcctttta ctgctgctgg aagggggtgg tgtgtcgccc caaaagcagg gcttcaatta 3660 agaaatgcct ctttgaaagg tgtaccttgg gtatcctgtc tgagggtaac tccagggtgc 3720 gccacaatgt ggcctccgac tgtggttgct tcatgctagt gaaaagcgtg gctgtgatta 3780 agcataacat ggtatgtggc aactgcgagg acagggcctc tcagatgctg acctgctcgg 3840 acggcaactg tcacctgctg aagaccattc acgtagccag ccactctcgc aaggcctggc 3900 cagtgtttga gcataacata ctgacccgct gttccttgca tttgggtaac aggagggggg 3960 tgttcctacc ttaccaatgc aatttgagtc acactaagat attgcttgag cccgagagca 4020 tgtccaaggt gaacctgaac ggggtgtttg acatgaccat gaagatctgg aaggtgctga 4080 ggtacgatga gacccgcacc aggtgcagac cctgcgagtg tggcggtaaa catattagga 4140 accagcctgt gatgctggat gtgaccgagg agctgaggcc cgatcacttg gtgctggcct 4200 gcacccgcgc tgagtttggc tctagcgatg aagatacaga ttgaggtact gaaatgtgtg 4260 ggcgtggctt aagggtggga aagaatatat aaggtggggg tcttatgtag ttttgtatct 4320 gttttgcagc agccgccgcc gcccaacttt tctatacaaa gttgtaatga gcaccaactc 4380 gtttgatgga agcattgtga gctcatattt gacaacgcgc atgcccccat gggccggggt 4440 gcgtcagaat gtgatgggct ccagcattga tggtcgcccc gtcctgcccg caaactctac 4500 taccttgacc tacgagaccg tgtctggaac gccgttggag actgcagcct ccgccgccgc 4560 ttcagccgct gcagccaccg cccgcgggat tgtgactgac tttgctttcc tgagcccgct 4620 tgcaagcagt gcagcttccc gttcatccgc ccgcgatgac aagttgacgg ctcttttggc 4680 acaattggat tctttgaccc gggaacttaa tgtcgtttct cagcagctgt tggatctgcg 4740 ccagcaggtt tctgccctga aggcttcctc ccctcccaat gcggtttaaa acataaataa 4800 aaaaccagac tctgtttgga tttggatcaa gcataagtgt cttgctgtct ttatttaggg 4860 gttttgcgcg cgcggtaggc ccgggaccag cggtctcggt cgttgagggt cctgtgtatt 4920 ttttccagga cgtggtaaag gtgactctgg atgttcagat acatgggcat aagcccgtct 4980 ctggggtgga ggtagcacca ctgcagagct tcatgctgcg gggtggtgtt gtagatgatc 5040 cagtcgtagc aggagcgctg ggcgtggtgc ctaaaaatgt ctttcagtag caagctgatt 5100 gccaggggca ggcccttggt gtaagtgttt acaaagcggt taagctggga tgggtgcata 5160 cgtggggata tgagatgcat cttggactgt atttttaggt tggctatgtt cccagccata 5220 tccctccggg gattcatgtt gtgcagaacc accagcacag tgtatccggt gcacttggga 5280 aatttgtcat gtagcttaga aggaaatgcg tggaagaact tggagacgcc cttgtgacct 5340 ccaagatttt ccatgcattc gtccataatg atggcaatgg gcccacgggc ggcggcctgg 5400 gcgaagatat ttctgggatc actaacgtca tagttgtgtt ccaggatgag atcgtcatag 5460 gccattttta caaagcgcgg gcggagggtg ccagactgcg gtataatggt tccatccggc 5520 ccaggggcgt agttaccctc acagatttgc atttcccacg ctttgagttc agatgggggg 5580 atcatgtcta cctgcggggc gatgaagaaa acggtttccg gggtagggga gatcagctgg 5640 gaagaaagca ggttcctgag cagctgcgac ttaccgcagc cggtgggccc gtaaatcaca 5700 cctattaccg ggtgcaactg gtagttaaga gagctgcagc tgccgtcatc cctgagcagg 5760 ggggccactt cgttaagcat gtccctgact cgcatgtttt ccctgaccaa atccgccaga 5820 aggcgctcgc cgcccagcga tagcagttct tgcaaggaag caaagttttt caacggtttg 5880 agaccgtccg ccgtaggcat gcttttgagc gtttgaccaa gcagttccag gcggtcccac 5940 agctcggtca cctgctctac ggcatctcga tccagcatat ctcctcgttt cgcgggttgg 6000 ggcggctttc gctgtacggc agtagtcggt gctcgtccag acgggccagg gtcatgtctt 6060 tccacgggcg cagggtcctc gtcagcgtag tctgggtcac ggtgaagggg tgcgctccgg 6120 gctgcgcgct ggccagggtg cgcttgaggc tggtcctgct ggtgctgaag cgctgccggt 6180 cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt gtcatagtcc agcccctccg 6240 cggcgtggcc cttggcgcgc agcttgccct tggaggaggc gccgcacgag gggcagtgca 6300 gacttttgag ggcgtagagc ttgggcgcga gaaataccga ttccggggag taggcatccg 6360 cgccgcaggc cccgcagacg gtctcgcatt ccacgagcca ggtgagctct ggccgttcgg 6420 ggtcaaaaac caggtttccc ccatgctttt tgatgcgttt cttacctctg gtttccatga 6480 gccggtgtcc acgctcggtg acgaaaaggc tgtccgtgtc cccgtataca gacttgagag 6540 gcctgtcctc gagcggtgtt ccgcggtcct cctcgtatag aaactcggac cactctgaga 6600 caaaggctcg cgtccaggcc agcacgaagg aggctaagtg ggaggggtag cggtcgttgt 6660 ccactagggg gtccactcgc tccagggtgt gaagacacat gtcgccctct tcggcatcaa 6720 ggaaggtgat tggtttgtag gtgtaggcca cgtgaccggg tgttcctgaa ggggggctat 6780 aaaagggggt gggggcgcgt tcgtcctcac tctcttccgc atcgctgtct gcgagggcca 6840 gctgttgggg tgagtactcc ctctgaaaag cgggcatgac ttctgcgcta agattgtcag 6900 tttccaaaaa cgaggaggat ttgatattca cctggcccgc ggtgatgcct ttgagggtgg 6960 ccgcatccat ctggtcagaa aagacaatct ttttgttgtc aagcttggtg gcaaacgacc 7020 cgtagagggc gttggacagc aacttggcga tggagcgcag ggtttggttt ttgtcgcgat 7080 cggcgcgctc cttggccgcg atgtttagct gcacgtattc gcgcgcaacg caccgccatt 7140 cgggaaagac ggtggtgcgc tcgtcgggca ccaggtgcac gcgccaaccg cggttgtgca 7200 gggtgacaag gtcaacgctg gtggctacct ctccgcgtag gcgctcgttg gtccagcaga 7260 ggcggccgcc cttgcgcgag cagaatggcg gtagggggtc tagctgcgtc tcgtccgggg 7320 ggtctgcgtc cacggtaaag accccgggca gcaggcgcgc gtcgaagtag tctatcttgc 7380 atccttgcaa gtctagcgcc tgctgccatg cgcgggcggc aagcgcgcgc tcgtatgggt 7440 tgagtggggg accccatggc atggggtggg tgagcgcgga ggcgtacatg ccgcaaatgt 7500 cgtaaacgta gaggggctct ctgagtattc caagatatgt agggtagcat cttccaccgc 7560 ggatgctggc gcgcacgtaa tcgtatagtt cgtgcgaggg agcgaggagg tcgggaccga 7620 ggttgctacg ggcgggctgc tctgctcgga agactatctg cctgaagatg gcatgtgagt 7680 tggatgatat ggttggacgc tggaagacgt tgaagctggc gtctgtgaga cctaccgcgt 7740 cacgcacgaa ggaggcgtag gagtcgcgca gcttgttgac cagctcggcg gtgacctgca 7800 cgtctagggc gcagtagtcc agggtttcct tgatgatgtc atacttatcc tgtccctttt 7860 ttttccacag ctcgcggttg aggacaaact cttcgcggtc tttccagtac tcttggatcg 7920 gaaacccgtc ggcctccgaa cggtaagagc ctagcatgta gaactggttg acggcctggt 7980 aggcgcagca tcccttttct acgggtagcg cgtatgcctg cgcggccttc cggagcgagg 8040 tgtgggtgag cgcaaaggtg tccctgacca tgactttgag gtactggtat ttgaagtcag 8100 tgtcgtcgca tccgccctgc tcccagagca aaaagtccgt gcgctttttg gaacgcggat 8160 ttggcagggc gaaggtgaca tcgttgaaga gtatctttcc cgcgcgaggc ataaagttgc 8220 gtgtgatgcg gaagggtccc ggcacctcgg aacggttgtt aattacctgg gcggcgagca 8280 cgatctcgtc aaagccgttg atgttgtggc ccacaatgta aagttccaag aagcgcggga 8340 tgcccttgat ggaaggcaat tttttaagtt cctcgtaggt gagctcttca ggggagctga 8400 gcccgtgctc tgaaagggcc cagtctgcaa gatgagggtt ggaagcgacg aatgagctcc 8460 acaggtcacg ggccattagc atttgcaggt ggtcgcgaaa ggtcctaaac tggcgaccta 8520 tggccatttt ttctggggtg atgcagtaga aggtaagcgg gtcttgttcc cagcggtccc 8580 atccaaggtt cgcggctagg tctcgcgcgg cagtcactag aggctcatct ccgccgaact 8640 tcatgaccag catgaagggc acgagctgct tcccaaaggc ccccatccaa gtataggtct 8700 ctacatcgta ggtgacaaag agacgctcgg tgcgaggatg cgagccgatc gggaagaact 8760 ggatctcccg ccaccaattg gaggagtggc tattgatgtg gtgaaagtag aagtccctgc 8820 gacgggccga acactcgtgc tggcttttgt aaaaacgtgc gcagtactgg cagcggtgca 8880 cgggctgtac atcctgcacg aggttgacct gacgaccgcg cacaaggaag cagagtggga 8940 atttgagccc ctcgcctggc gggtttggct ggtggtcttc tacttcggct gcttgtcctt 9000 gaccgtctgg ctgctcgagg ggagttacgg tggatcggac caccacgccg cgcgagccca 9060 aagtccagat gtccgcgcgc ggcggtcgga gcttgatgac aacatcgcgc agatgggagc 9120 tgtccatggt ctggagctcc cgcggcgtca ggtcaggcgg gagctcctgc aggtttacct 9180 cgcatagacg ggtcagggcg cgggctagat ccaggtgata cctaatttcc aggggctggt 9240 tggtggcggc gtcgatggct tgcaagaggc cgcatccccg cggcgcgact acggtaccgc 9300 gcggcgggcg gtgggccgcg ggggtgtcct tggatgatgc atctaaaagc ggtgacgcgg 9360 gcgagccccc ggaggtaggg ggggctccgg acccgccggg agagggggca ggggcacgtc 9420 ggcgccgcgc gcgggcagga gctggtgctg cgcgcgtagg ttgctggcga acgcgacgac 9480 gcggcggttg atctcctgaa tctggcgcct ctgcgtgaag acgacgggcc cggtgagctt 9540 gagcctgaaa gagagttcga cagaatcaat ttcggtgtcg ttgacggcgg cctggcgcaa 9600 aatctcctgc acgtctcctg agttgtcttg ataggcgatc tcggccatga actgctcgat 9660 ctcttcctcc tggagatctc cgcgtccggc tcgctccacg gtggcggcga ggtcgttgga 9720 aatgcgggcc atgagctgcg agaaggcgtt gaggcctccc tcgttccaga cgcggctgta 9780 gaccacgccc ccttcggcat cgcgggcgcg catgaccacc tgcgcgagat tgagctccac 9840 gtgccgggcg aagacggcgt agtttcgcag gcgctgaaag aggtagttga gggtggtggc 9900 ggtgtgttct gccacgaaga agtacataac ccagcgtcgc aacgtggatt cgttgatatc 9960 ccccaaggcc tcaaggcgct ccatggcctc gtagaagtcc acggcgaagt tgaaaaactg 10020 ggagttgcgc gccgacacgg ttaactcctc ctccagaaga cggatgagct cggcgacagt 10080 gtcgcgcacc tcgcgctcaa aggctacagg ggcctcttct tcttcttcaa tctcctcttc 10140 cataagggcc tccccttctt cttcttctgg cggcggtggg ggagggggga cacggcggcg 10200 acgacggcgc accgggaggc ggtcgacaaa gcgctcgatc atctccccgc ggcgacggcg 10260 catggtctcg gtgacggcgc ggccgttctc gcgggggcgc agttggaaga cgccgcccgt 10320 catgtcccgg ttatgggttg gcggggggct gccatgcggc agggatacgg cgctaacgat 10380 gcatctcaac aattgttgtg taggtactcc gccgccgagg gacctgagcg agtccgcatc 10440 gaccggatcg gaaaacctct cgagaaaggc gtctaaccag tcacagtcgc aaggtaggct 10500 gagcaccgtg gcgggcggca gcgggcggcg gtcggggttg tttctggcgg aggtgctgct 10560 gatgatgtaa ttaaagtagg cggtcttgag acggcggatg gtcgacagaa gcaccatgtc 10620 cttgggtccg gcctgctgaa tgcgcaggcg gtcggccatg ccccaggctt cgttttgaca 10680 tcggcgcagg tctttgtagt agtcttgcat gagcctttct accggcactt cttcttctcc 10740 ttcctcttgt cctgcatctc ttgcatctat cgctgcggcg gcggcggagt ttggccgtag 10800 gtggcgccct cttcctccca tgcgtgtgac cccgaagccc ctcatcggct gaagcagggc 10860 taggtcggcg acaacgcgct cggctaatat ggcctgctgc acctgcgtga gggtagactg 10920 gaagtcatcc atgtccacaa agcggtggta tgcgcccgtg ttgatggtgt aagtgcagtt 10980 ggccataacg gaccagttaa cggtctggtg acccggctgc gagagctcgg tgtacctgag 11040 acgcgagtaa gccctcgagt caaatacgta gtcgttgcaa gtccgcacca ggtactggta 11100 tcccaccaaa aagtgcggcg gcggctggcg gtagaggggc cagcgtaggg tggccggggc 11160 tccgggggcg agatcttcca acataaggcg atgatatccg tagatgtacc tggacatcca 11220 ggtgatgccg gcggcggtgg tggaggcgcg cggaaagtcg cggacgcggt tccagatgtt 11280 gcgcagcggc aaaaagtgct ccatggtcgg gacgctctgg ccggtcaggc gcgcgcaatc 11340 gttgacgctc tagaccgtgc aaaaggagag cctgtaagcg ggcactcttc cgtggtctgg 11400 tggataaatt cgcaagggta tcatggcgga cgaccggggt tcgagccccg tatccggccg 11460 tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc caggtgtgcg acgtcagaca 11520 acgggggagt gctccttttg gcttccttcc aggcgcggcg gctgctgcgc tagctttttt 11580 ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa gcgaaagcat taagtggctc 11640 gctccctgta gccggagggt tattttccaa gggttgagtc gcgggacccc cggttcgagt 11700 ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc ccgtcatgca agaccccgct 11760 tgcaaattcc tccggaaaca gggacgagcc ccttttttgc ttttcccaga tgcatccggt 11820 gctgcggcag atgcgccccc ctcctcagca gcggcaagag caagagcagc ggcagacatg 11880 cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg acatccgcgg ttgacgcggc 11940 agcagatggt gattacgaac ccccgcggcg ccgggcccgg cactacctgg acttggagga 12000 gggcgagggc ctggcgcggc taggagcgcc ctctcctgag cggtacccaa gggtgcagct 12060 gaagcgtgat acgcgtgagg cgtacgtgcc gcggcagaac ctgtttcgcg accgcgaggg 12120 agaggagccc gaggagatgc gggatcgaaa gttccacgca gggcgcgagc tgcggcatgg 12180 cctgaatcgc gagcggttgc tgcgcgagga ggactttgag cccgacgcgc gaaccgggat 12240 tagtcccgcg cgcgcacacg tggcggccgc cgacctggta accgcatacg agcagacggt 12300 gaaccaggag attaactttc aaaaaagctt taacaaccac gtgcgtacgc ttgtggcgcg 12360 cgaggaggtg gctataggac tgatgcatct gtgggacttt gtaagcgcgc tggagcaaaa 12420 cccaaatagc aagccgctca tggcgcagct gttccttata gtgcagcaca gcagggacaa 12480 cgaggcattc agggatgcgc tgctaaacat agtagagccc gagggccgct ggctgctcga 12540 tttgataaac atcctgcaga gcatagtggt gcaggagcgc agcttgagcc tggctgacaa 12600 ggtggccgcc atcaactatt ccatgcttag cctgggcaag ttttacgccc gcaagatata 12660 ccatacccct tacgttccca tagacaagga ggtaaagatc gaggggttct acatgcgcat 12720 ggcgctgaag gtgcttacct tgagcgacga cctgggcgtt tatcgcaacg agcgcatcca 12780 caaggccgtg agcgtgagcc ggcggcgcga gctcagcgac cgcgagctga tgcacagcct 12840 gcaaagggcc ctggctggca cgggcagcgg cgatagagag gccgagtcct actttgacgc 12900 gggcgctgac ctgcgctggg ccccaagccg acgcgccctg gaggcagctg gggccggacc 12960 tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc ggcgtggagg aatatgacga 13020 ggacgatgag tacgagccag aggacggcga gtactaagcg gtgatgtttc tgatcagatg 13080 atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc agagccagcc gtccggcctt 13140 aactccacgg acgactggcg ccaggtcatg gaccgcatca tgtcgctgac tgcgcgcaat 13200 cctgacgcgt tccggcagca gccgcaggcc aaccggctct ccgcaattct ggaagcggtg 13260 gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg cgatcgtaaa cgcgctggcc 13320 gaaaacaggg ccatccggcc cgacgaggcc ggcctggtct acgacgcgct gcttcagcgc 13380 gtggctcgtt acaacagcgg caacgtgcag accaacctgg accggctggt gggggatgtg 13440 cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg gcaacctggg ctccatggtt 13500 gcactaaacg ccttcctgag tacacagccc gccaacgtgc cgcggggaca ggaggactac 13560 accaactttg tgagcgcact gcggctaatg gtgactgaga caccgcaaag tgaggtgtac 13620 cagtctgggc cagactattt tttccagacc agtagacaag gcctgcagac cgtaaacctg 13680 agccaggctt tcaaaaactt gcaggggctg tggggggtgc gggctcccac aggcgaccgc 13740 gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt tgctgctgct aatagcgccc 13800 ttcacggaca gtggcagcgt gtcccgggac acatacctag gtcacttgct gacactgtac 13860 cgcgaggcca taggtcaggc gcatgtggac gagcatactt tccaggagat tacaagtgtc 13920 agccgcgcgc tggggcagga ggacacgggc agcctggagg caaccctaaa ctacctgctg 13980 accaaccggc ggcagaagat cccctcgttg cacagtttaa acagcgagga ggagcgcatt 14040 ttgcgctacg tgcagcagag cgtgagcctt aacctgatgc gcgacggggt aacgcccagc 14100 gtggcgctgg acatgaccgc gcgcaacatg gaaccgggca tgtatgcctc aaaccggccg 14160 tttatcaacc gcctaatgga ctacttgcat cgcgcggccg ccgtgaaccc cgagtatttc 14220 accaatgcca tcttgaaccc gcactggcta ccgccccctg gtttctacac cgggggattc 14280 gaggtgcccg agggtaacga tggattcctc tgggacgaca tagacgacag cgtgttttcc 14340 ccgcaaccgc agaccctgct agagttgcaa cagcgcgagc aggcagaggc ggcgctgcga 14400 aaggaaagct tccgcaggcc aagcagcttg tccgatctag gcgctgcggc cccgcggtca 14460 gatgctagta gcccatttcc aagcttgata gggtctctta ccagcactcg caccacccgc 14520 ccgcgcctgc tgggcgagga ggagtaccta aacaactcgc tgctgcagcc gcagcgcgaa 14580 aaaaacctgc ctccggcatt tcccaacaac gggatagaga gcctagtgga caagatgagt 14640 agatggaaga cgtacgcgca ggagcacagg gacgtgccag gcccgcgccc gcccacccgt 14700 cgtcaaaggc acgaccgtca gcggggtctg gtgtgggagg acgatgactc ggcagacgac 14760 agcagcgtcc tggatttggg agggagtggc aacccgtttg cgcaccttcg ccccaggctg 14820 gggagaatgt tttaaaaaaa aaaaagcatg atgcaaaata aaaaactcac caaggccatg 14880 gcaccgagcg ttggttttct tgtattcccc ttagtatgcg gcgcgcggcg atgtatgagg 14940 aaggtcctcc tccctcctac gagagtgtgg tgagcgcggc gccagtggcg gcggcgctgg 15000 gttctccctt cgatgctccc ctggacccgc cgtttgtgcc tccgcggtac ctgcggccta 15060 ccggggggag aaacagcatc cgttactctg agttggcacc cctattcgac accacccgtg 15120 tgtacctggt ggacaacaag tcaacggatg tggcatccct gaactaccag aacgaccaca 15180 gcaactttct gaccacggtc attcaaaaca atgactacag cccgggggag gcaagcacac 15240 agaccatcaa tcttgacgac cggtcgcact ggggcggcga cctgaaaacc atcctgcata 15300 ccaacatgcc aaatgtgaac gagttcatgt ttaccaataa gtttaaggcg cgggtgatgg 15360 tgtcgcgctt gcctactaag gacaatcagg tggagctgaa atacgagtgg gtggagttca 15420 cgctgcccga gggcaactac tccgagacca tgaccataga ccttatgaac aacgcgatcg 15480 tggagcacta cttgaaagtg ggcagacaga acggggttct ggaaagcgac atcggggtaa 15540 agtttgacac ccgcaacttc agactggggt ttgaccccgt cactggtctt gtcatgcctg 15600 gggtatatac aaacgaagcc ttccatccag acatcatttt gctgccagga tgcggggtgg 15660 acttcaccca cagccgcctg agcaacttgt tgggcatccg caagcggcaa cccttccagg 15720 agggctttag gatcacctac gatgatctgg agggtggtaa cattcccgca ctgttggatg 15780 tggacgccta ccaggcgagc ttgaaagatg acaccgaaca gggcgggggt ggcgcaggcg 15840 gcagcaacag cagtggcagc ggcgcggaag agaactccaa cgcggcagcc gcggcaatgc 15900 agccggtgga ggacatgaac gatcatgcca ttcgcggcga cacctttgcc acacgggctg 15960 aggagaagcg cgctgaggcc gaagcagcgg ccgaagctgc cgcccccgct gcgcaacccg 16020 aggtcgagaa gcctcagaag aaaccggtga tcaaacccct gacagaggac agcaagaaac 16080 gcagttacaa cctaataagc aatgacagca ccttcaccca gtaccgcagc tggtaccttg 16140 catacaacta cggcgaccct cagaccggaa tccgctcatg gaccctgctt tgcactcctg 16200 acgtaacctg cggctcggag caggtctact ggtcgttgcc agacatgatg caagaccccg 16260 tgaccttccg ctccacgcgc cagatcagca actttccggt ggtgggcgcc gagctgttgc 16320 ccgtgcactc caagagcttc tacaacgacc aggccgtcta ctcccaactc atccgccagt 16380 ttacctctct gacccacgtg ttcaatcgct ttcccgagaa ccagattttg gcgcgcccgc 16440 cagcccccac catcaccacc gtcagtgaaa acgttcctgc tctcacagat cacgggacgc 16500 taccgctgcg caacagcatc ggaggagtcc agcgagtgac cattactgac gccagacgcc 16560 gcacctgccc ctacgtttac aaggccctgg gcatagtctc gccgcgcgtc ctatcgagcc 16620 gcactttttg agcaagcatg tccatcctta tatcgcccag caataacaca ggctggggcc 16680 tgcgcttccc aagcaagatg tttggcgggg ccaagaagcg ctccgaccaa cacccagtgc 16740 gcgtgcgcgg gcactaccgc gcgccctggg gcgcgcacaa acgcggccgc actgggcgca 16800 ccaccgtcga tgacgccatc gacgcggtgg tggaggaggc gcgcaactac acgcccacgc 16860 cgccaccagt gtccacagtg gacgcggcca ttcagaccgt ggtgcgcgga gcccggcgct 16920 atgctaaaat gaagagacgg cggaggcgcg tagcacgtcg ccaccgccgc cgacccggca 16980 ctgccgccca acgcgcggcg gcggccctgc ttaaccgcgc acgtcgcacc ggccgacggg 17040 cggccatgcg ggccgctcga aggctggccg cgggtattgt cactgtgccc cccaggtcca 17100 ggcgacgagc ggccgccgca gcagccgcgg ccattagtgc tatgactcag ggtcgcaggg 17160 gcaacgtgta ttgggtgcgc gactcggtta gcggcctgcg cgtgcccgtg cgcacccgcc 17220 ccccgcgcaa ctagattgca agaaaaaact acttagactc gtactgttgt atgtatccag 17280 cggcggcggc gcgcaacgaa gctatgtcca agcgcaaaat caaagaagag atgctccagg 17340 tcatcgcgcc ggagatctat ggccccccga agaaggaaga gcaggattac aagccccgaa 17400 agctaaagcg ggtcaaaaag aaaaagaaag atgatgatga tgaacttgac gacgaggtgg 17460 aactgctgca cgctaccgcg cccaggcgac gggtacagtg gaaaggtcga cgcgtaaaac 17520 gtgttttgcg acccggcacc accgtagtct ttacgcccgg tgagcgctcc acccgcacct 17580 acaagcgcgt gtatgatgag gtgtacggcg acgaggacct gcttgagcag gccaacgagc 17640 gcctcgggga gtttgcctac ggaaagcggc ataaggacat gctggcgttg ccgctggacg 17700 agggcaaccc aacacctagc ctaaagcccg taacactgca gcaggtgctg cccgcgcttg 17760 caccgtccga agaaaagcgc ggcctaaagc gcgagtctgg tgacttggca cccaccgtgc 17820 agctgatggt acccaagcgc cagcgactgg aagatgtctt ggaaaaaatg accgtggaac 17880 ctgggctgga gcccgaggtc cgcgtgcggc caatcaagca ggtggcgccg ggactgggcg 17940 tgcagaccgt ggacgttcag atacccacta ccagtagcac cagtattgcc accgccacag 18000 agggcatgga gacacaaacg tccccggttg cctcagcggt ggcggatgcc gcggtgcagg 18060 cggtcgctgc ggccgcgtcc aagacctcta cggaggtgca aacggacccg tggatgtttc 18120 gcgtttcagc cccccggcgc ccgcgcggtt cgaggaagta cggcgccgcc agcgcgctac 18180 tgcccgaata tgccctacat ccttccattg cgcctacccc cggctatcgt ggctacacct 18240 accgccccag aagacgagca actacccgac gccgaaccac cactggaacc cgccgccgcc 18300 gtcgccgtcg ccagcccgtg ctggccccga tttccgtgcg cagggtggct cgcgaaggag 18360 gcaggaccct ggtgctgcca acagcgcgct accaccccag catcgtttaa aagccggtct 18420 ttgtggttct tgcagatatg gccctcacct gccgcctccg tttcccggtg ccgggattcc 18480 gaggaagaat gcaccgtagg aggggcatgg ccggccacgg cctgacgggc ggcatgcgtc 18540 gtgcgcacca ccggcggcgg cgcgcgtcgc accgtcgcat gcgcggcggt atcctgcccc 18600 tccttattcc actgatcgcc gcggcgattg gcgccgtgcc cggaattgca tccgtggcct 18660 tgcaggcgca gagacactga ttaaaaacaa gttgcatgtg gaaaaatcaa aataaaaagt 18720 ctggactctc acgctcgctt ggtcctgtaa ctattttgta gaatggaaga catcaacttt 18780 gcgtctctgg ccccgcgaca cggctcgcgc ccgttcatgg gaaactggca agatatcggc 18840 accagcaata tgagcggtgg cgccttcagc tggggctcgc tgtggagcgg cattaaaaat 18900 ttcggttcca ccgttaagaa ctatggcagc aaggcctgga acagcagcac aggccagatg 18960 ctgagggata agttgaaaga gcaaaatttc caacaaaagg tggtagatgg cctggcctct 19020 ggcattagcg gggtggtgga cctggccaac caggcagtgc aaaataagat taacagtaag 19080 cttgatcccc gccctcccgt agaggagcct ccaccggccg tggagacagt gtctccagag 19140 gggcgtggcg aaaagcgtcc gcgccccgac agggaagaaa ctctggtgac gcaaatagac 19200 gagcctccct cgtacgagga ggcactaaag caaggcctgc ccaccacccg tcccatcgcg 19260 cccatggcta ccggagtgct gggccagcac acacccgtaa cgctggacct gcctcccccc 19320 gccgacaccc agcagaaacc tgtgctgcca ggcccgaccg ccgttgttgt aacccgtcct 19380 agccgcgcgt ccctgcgccg cgccgccagc ggtccgcgat cgttgcggcc cgtagccagt 19440 ggcaactggc aaagcacact gaacagcatc gtgggtctgg gggtgcaatc cctgaagcgc 19500 cgacgatgct tctgaatagc taacgtgtcg tatgtgtgtc atgtatgcgt ccatgtcgcc 19560 gccagaggag ctgctgagcc gccgcgcgcc cgctttccaa gatggctacc ccttcgatga 19620 tgccgcagtg gtcttacatg cacatctcgg gccaggacgc ctcggagtac ctgagccccg 19680 ggctggtgca gtttgcccgc gccaccgaga cgtacttcag cctgaataac aagtttagaa 19740 accccacggt ggcgcctacg cacgacgtga ccacagaccg gtcccagcgt ttgacgctgc 19800 ggttcatccc tgtggaccgt gaggatactg cgtactcgta caaggcgcgg ttcaccctag 19860 ctgtgggtga taaccgtgtg ctggacatgg cttccacgta ctttgacatc cgcggcgtgc 19920 tggacagggg ccctactttt aagccctact ctggcactgc ctacaacgcc ctggctccca 19980 agggtgcccc aaatccttgc gaatgggatg aagctgctac tgctcttgaa ataaacctag 20040 aagaagagga cgatgacaac gaagacgaag tagacgagca agctgagcag caaaaaactc 20100 acgtatttgg gcaggcgcct tattctggta taaatattac aaaggagggt attcaaatag 20160 gtgtcgaagg tcaaacacct aaatatgccg ataaaacatt tcaacctgaa cctcaaatag 20220 gagaatctca gtggtacgaa actgaaatta atcatgcagc tgggagagtc cttaaaaaga 20280 ctaccccaat gaaaccatgt tacggttcat atgcaaaacc cacaaatgaa aatggagggc 20340 aaggcattct tgtaaagcaa caaaatggaa agctagaaag tcaagtggaa atgcaatttt 20400 tctcaactac tgaggcgacc gcaggcaatg gtgataactt gactcctaaa gtggtattgt 20460 acagtgaaga tgtagatata gaaaccccag acactcatat ttcttacatg cccactatta 20520 aggaaggtaa ctcacgagaa ctaatgggcc aacaatctat gcccaacagg cctaattaca 20580 ttgcttttag ggacaatttt attggtctaa tgtattacaa cagcacgggt aatatgggtg 20640 ttctggcggg ccaagcatcg cagttgaatg ctgttgtaga tttgcaagac agaaacacag 20700 agctttcata ccagcttttg cttgattcca ttggtgatag aaccaggtac ttttctatgt 20760 ggaatcaggc tgttgacagc tatgatccag atgttagaat tattgaaaat catggaactg 20820 aagatgaact tccaaattac tgctttccac tgggaggtgt gattaataca gagactctta 20880 ccaaggtaaa acctaaaaca ggtcaggaaa atggatggga aaaagatgct acagaatttt 20940 cagataaaaa tgaaataaga gttggaaata attttgccat ggaaatcaat ctaaatgcca 21000 acctgtggag aaatttcctg tactccaaca tagcgctgta tttgcccgac aagctaaagt 21060 acagtccttc caacgtaaaa atttctgata acccaaacac ctacgactac atgaacaagc 21120 gagtggtggc tcccgggtta gtggactgct acattaacct tggagcacgc tggtcccttg 21180 actatatgga caacgtcaac ccatttaacc accaccgcaa tgctggcctg cgctaccgct 21240 caatgttgct gggcaatggt cgctatgtgc ccttccacat ccaggtgcct cagaagttct 21300 ttgccattaa aaacctcctt ctcctgccgg gctcatacac ctacgagtgg aacttcagga 21360 aggatgttaa catggttctg cagagctccc taggaaatga cctaagggtt gacggagcca 21420 gcattaagtt tgatagcatt tgcctttacg ccaccttctt ccccatggcc cacaacaccg 21480 cctccacgct tgaggccatg cttagaaacg acaccaacga ccagtccttt aacgactatc 21540 tctccgccgc caacatgctc taccctatac ccgccaacgc taccaacgtg cccatatcca 21600 tcccctcccg caactgggcg gctttccgcg gctgggcctt cacgcgcctt aagactaagg 21660 aaaccccatc actgggctcg ggctacgacc cttattacac ctactctggc tctataccct 21720 acctagatgg aaccttttac ctcaaccaca cctttaagaa ggtggccatt acctttgact 21780 cttctgtcag ctggcctggc aatgaccgcc tgcttacccc caacgagttt gaaattaagc 21840 gctcagttga cggggagggt tacaacgttg cccagtgtaa catgaccaaa gactggttcc 21900 tggtacaaat gctagctaac tacaacattg gctaccaggg cttctatatc ccagagagct 21960 acaaggaccg catgtactcc ttctttagaa acttccagcc catgagccgt caggtggtgg 22020 atgatactaa atacaaggac taccaacagg tgggcatcct acaccaacac aacaactctg 22080 gatttgttgg ctaccttgcc cccaccatgc gcgaaggaca ggcctaccct gctaacttcc 22140 cctatccgct tataggcaag accgcagttg acagcattac ccagaaaaag tttctttgcg 22200 atcgcaccct ttggcgcatc ccattctcca gtaactttat gtccatgggc gcactcacag 22260 acctgggcca aaaccttctc tacgccaact ccgcccacgc gctagacatg acttttgagg 22320 tggatcccat ggacgagccc acccttcttt atgttttgtt tgaagtcttt gacgtggtcc 22380 gtgtgcaccg gccgcaccgc ggcgtcatcg aaaccgtgta cctgcgcacg cccttctcgg 22440 ccggcaacgc cacaacataa agaagcaagc aacatcaaca acagctgccg ccatgggctc 22500 cagtgagcag gaactgaaag ccattgtcaa agatcttggt tgtgggccat attttttggg 22560 cacctatgac aagcgctttc caggctttgt ttctccacac aagctcgcct gcgccatagt 22620 caatacggcc ggtcgcgaga ctgggggcgt acactggatg gcctttgcct ggaacccgca 22680 ctcaaaaaca tgctacctct ttgagccctt tggcttttct gaccagcgac tcaagcaggt 22740 ttaccagttt gagtacgagt cactcctgcg ccgtagcgcc attgcttctt cccccgaccg 22800 ctgtataacg ctggaaaagt ccacccaaag cgtacagggg cccaactcgg ccgcctgtgg 22860 actattctgc tgcatgtttc tccacgcctt tgccaactgg ccccaaactc ccatggatca 22920 caaccccacc atgaacctta ttaccggggt acccaactcc atgctcaaca gtccccaggt 22980 acagcccacc ctgcgtcgca accaggaaca gctctacagc ttcctggagc gccactcgcc 23040 ctacttccgc agccacagtg cgcagattag gagcgccact tctttttgtc acttgaaaaa 23100 catgtaaaaa taatgtacta gagacacttt caataaaggc aaatgctttt atttgtacac 23160 tctcgggtga ttatttaccc ccacccttgc cgtctgcgcc gtttaaaaat caaaggggtt 23220 ctgccgcgca tcgctatgcg ccactggcag ggacacgttg cgatactggt gtttagtgct 23280 ccacttaaac tcaggcacaa ccatccgcgg cagctcggtg aagttttcac tccacaggct 23340 gcgcaccatc accaacgcgt ttagcaggtc gggcgccgat atcttgaagt cgcagttggg 23400 gcctccgccc tgcgcgcgcg agttgcgata cacagggttg cagcactgga acactatcag 23460 cgccgggtgg tgcacgctgg ccagcacgct cttgtcggag atcagatccg cgtccaggtc 23520 ctccgcgttg ctcagggcga acggagtcaa ctttggtagc tgccttccca aaaagggcgc 23580 gtgcccaggc tttgagttgc actcgcaccg tagtggcatc aaaaggtgac cgtgcccggt 23640 ctgggcgtta ggatacagcg cctgcataaa agccttgatc tgcttaaaag ccacctgagc 23700 ctttgcgcct tcagagaaga acatgccgca agacttgccg gaaaactgat tggccggaca 23760 ggccgcgtcg tgcacgcagc accttgcgtc ggtgttggag atctgcacca catttcggcc 23820 ccaccggttc ttcacgatct tggccttgct agactgctcc ttcagcgcgc gctgcccgtt 23880 ttcgctcgtc acatccattt caatcacgtg ctccttattt atcataatgc ttccgtgtag 23940 acacttaagc tcgccttcga tctcagcgca gcggtgcagc cacaacgcgc agcccgtggg 24000 ctcgtgatgc ttgtaggtca cctctgcaaa cgactgcagg tacgcctgca ggaatcgccc 24060 catcatcgtc acaaaggtct tgttgctggt gaaggtcagc tgcaacccgc ggtgctcctc 24120 gttcagccag gtcttgcata cggccgccag agcttccact tggtcaggca gtagtttgaa 24180 gttcgccttt agatcgttat ccacgtggta cttgtccatc agcgcgcgcg cagcctccat 24240 gcccttctcc cacgcagaca cgatcggcac actcagcggg ttcatcaccg taatttcact 24300 ttccgcttcg ctgggctctt cctcttcctc ttgcgtccgc ataccacgcg ccactgggtc 24360 gtcttcattc agccgccgca ctgtgcgctt acctcctttg ccatgcttga ttagcaccgg 24420 tgggttgctg aaacccacca tttgtagcgc cacatcttct ctttcttcct cgctgtccac 24480 gattacctct ggtgatggcg ggcgctcggg cttgggagaa gggcgcttct ttttcttctt 24540 gggcgcaatg gccaaatccg ccgccgaggt cgatggccgc gggctgggtg tgcgcggcac 24600 cagcgcgtct tgtgatgagt cttcctcgtc ctcggactcg atacgccgcc tcatccgctt 24660 ttttgggggc gcccggggag gcggcggcga cggggacggg gacgacacgt cctccatggt 24720 tgggggacgt cgcgccgcac cgcgtccgcg ctcgggggtg gtttcgcgct gctcctcttc 24780 ccgactggcc atttccttct cctataggca gaaaaagatc atggagtcag tcgagaagaa 24840 ggacagccta accgccccct ctgagttcgc caccaccgcc tccaccgatg ccgccaacgc 24900 gcctaccacc ttccccgtcg aggcaccccc gcttgaggag gaggaagtga ttatcgagca 24960 ggacccaggt tttgtaagcg aagacgacga ggaccgctca gtaccaacag aggataaaaa 25020 gcaagaccag gacaacgcag aggcaaacga ggaacaagtc gggcgggggg acgaaaggca 25080 tggcgactac ctagatgtgg gagacgacgt gctgttgaag catctgcagc gccagtgcgc 25140 cattatctgc gacgcgttgc aagagcgcag cgatgtgccc ctcgccatag cggatgtcag 25200 ccttgcctac gaacgccacc tattctcacc gcgcgtaccc cccaaacgcc aagaaaacgg 25260 cacatgcgag cccaacccgc gcctcaactt ctaccccgta tttgccgtgc cagaggtgct 25320 tgccacctat cacatctttt tccaaaactg caagataccc ctatcctgcc gtgccaaccg 25380 cagccgagcg gacaagcagc tggccttgcg gcagggcgct gtcatacctg atatcgcctc 25440 gctcaacgaa gtgccaaaaa tctttgaggg tcttggacgc gacgagaagc gcgcggcaaa 25500 cgctctgcaa caggaaaaca gcgaaaatga aagtcactct ggagtgttgg tggaactcga 25560 gggtgacaac gcgcgcctag ccgtactaaa acgcagcatc gaggtcaccc actttgccta 25620 cccggcactt aacctacccc ccaaggtcat gagcacagtc atgagtgagc tgatcgtgcg 25680 ccgtgcgcag cccctggaga gggatgcaaa tttgcaagaa caaacagagg agggcctacc 25740 cgcagttggc gacgagcagc tagcgcgctg gcttcaaacg cgcgagcctg ccgacttgga 25800 ggagcgacgc aaactaatga tggccgcagt gctcgttacc gtggagcttg agtgcatgca 25860 gcggttcttt gctgacccgg agatgcagcg caagctagag gaaacattgc actacacctt 25920 tcgacagggc tacgtacgcc aggcctgcaa gatctccaac gtggagctct gcaacctggt 25980 ctcctacctt ggaattttgc acgaaaaccg ccttgggcaa aacgtgcttc attccacgct 26040 caagggcgag gcgcgccgcg actacgtccg cgactgcgtt tacttatttc tatgctacac 26100 ctggcagacg gccatgggcg tttggcagca gtgcttggag gagtgcaacc tcaaggagct 26160 gcagaaactg ctaaagcaaa acttgaagga cctatggacg gccttcaacg agcgctccgt 26220 ggccgcgcac ctggcggaca tcattttccc cgaacgcctg cttaaaaccc tgcaacaggg 26280 tctgccagac ttcaccagtc aaagcatgtt gcagaacttt aggaacttta tcctagagcg 26340 ctcaggaatc ttgcccgcca cctgctgtgc acttcctagc gactttgtgc ccattaagta 26400 ccgcgaatgc cctccgccgc tttggggcca ctgctacctt ctgcagctag ccaactacct 26460 tgcctaccac tctgacataa tggaagacgt gagcggtgac ggtctactgg agtgtcactg 26520 tcgctgcaac ctatgcaccc cgcaccgctc cctggtttgc aattcgcagc tgcttaacga 26580 aagtcaaatt atcggtacct ttgagctgca gggtccctcg cctgacgaaa agtccgcggc 26640 tccggggttg aaactcactc cggggctgtg gacgtcggct taccttcgca aatttgtacc 26700 tgaggactac cacgcccacg agattaggtt ctacgaagac caatcccgcc cgccaaatgc 26760 ggagcttacc gcctgcgtca ttacccaggg ccacattctt ggccaattgc aagccatcaa 26820 caaagcccgc caagagtttc tgctacgaaa gggacggggg gtttacttgg acccccagtc 26880 cggcgaggag ctcaacccaa tccccccgcc gccgcagccc tatcagcagc agccgcgggc 26940 ccttgcttcc caggatggca cccaaaaaga agctgcagct gccgccgcca cccacggacg 27000 aggaggaata ctgggacagt caggcagagg aggttttgga cgaggaggag gaggacatga 27060 tggaagactg ggagagccta gacgaggaag cttccgaggt cgaagaggtg tcagacgaaa 27120 caccgtcacc ctcggtcgca ttcccctcgc cggcgcccca gaaatcggca accggttcca 27180 gcatggctac aacctccgct cctcaggcgc cgccggcact gcccgttcgc cgacccaacc 27240 gtagatggga caccactgga accagggccg gtaagtccaa gcagccgccg ccgttagccc 27300 aagagcaaca acagcgccaa ggctaccgct catggcgcgg gcacaagaac gccatagttg 27360 cttgcttgca agactgtggg ggcaacatct ccttcgcccg ccgctttctt ctctaccatc 27420 acggcgtggc cttcccccgt aacatcctgc attactaccg tcatctctac agcccatact 27480 gcaccggcgg cagcggcagc ggcagcaaca gcagcggcca cacagaagca aaggcgaccg 27540 gatagcaaga ctctgacaaa gcccaagaaa tccacagcgg cggcagcagc aggaggagga 27600 gcgctgcgtc tggcgcccaa cgaacccgta tcgacccgcg agcttagaaa caggattttt 27660 cccactctgt atgctatatt tcaacagagc aggggccaag aacaagagct gaaaataaaa 27720 aacaggtctc tgcgatccct cacccgcagc tgcctgtatc acaaaagcga agatcagctt 27780 cggcgcacgc tggaagacgc ggaggctctc ttcagtaaat actgcgcgct gactcttaag 27840 gactagtttc gcgccctttc tcaaatttaa gcgcgaaaac tacgtcatct ccagcggcca 27900 cacccggcgc cagcacctgt cgtcagcgcc atttcaactt tgtatacaaa agttgtgatg 27960 agcaaggaaa ttcccacgcc ctacatgtgg agttaccagc cacaaatggg acttgcggct 28020 ggagctgccc aagactactc aacccgaata aactacatga gcgcgggacc ccacatgata 28080 tcccgggtca acggaatacg cgcccaccga aaccgaattc tcctggaaca ggcggctatt 28140 accaccacac ctcgtaataa ccttaatccc cgtagttggc ccgctgccct ggtgtaccag 28200 gaaagtcccg ctcccaccac tgtggtactt cccagagacg cccaggccga agttcagatg 28260 actaactcag gggcgcagct tgcgggcggc tttcgtcaca gggtgcggtc gcccgggcag 28320 ggtataactc acctgacaat cagagggcga ggtattcagc tcaacgacga gtcggtgagc 28380 tcctcgcttg gtctccgtcc ggacgggaca tttcagatcg gcggcgccgg ccgctcttca 28440 ttcacgcctc gtcaggcaat cctaactctg cagacctcgt cctctgagcc gcgctctgga 28500 ggcattggaa ctctgcaatt tattgaggag tttgtgccat cggtctactt taaccccttc 28560 tcgggacctc ccggccacta tccggatcaa tttattccta actttgacgc ggtaaaggac 28620 tcggcggacg gctacgactg aatgttaagt ggagaggcag agcaactgcg cctgaaacac 28680 ctggtccact gtcgccgcca caagtgcttt gcccgcgact ccggtgagtt ttgctacttt 28740 gaattgcccg aggatcatat cgagggcccg gcgcacggcg tccggcttac cgcccaggga 28800 gagcttgccc gtagcctgat tcgggagttt acccagcgcc ccctgctagt tgagcgggac 28860 aggggaccct gtgttctcac tgtgatttgc aactgtccta accctggatt acatcaagat 28920 ctttgttgcc atctctgtgc tgagtataat aaatacagaa attaaaatat actggggctc 28980 ctatcgccat cctgtaaacg ccaccgtctt cacccgccca agcaaaccaa ggcgaacctt 29040 acctggtact tttaacatct ctccctctgt gatttacaac agtttcaacc cagacggagt 29100 gagtctacga gagaacctct ccgagctcag ctactccatc agaaaaaaca ccaccctcct 29160 tacctgccgg gaacgtacga gtgcgtcacc ggccgctgca ccacacctac cgcctgaccg 29220 taaaccagac tttttccgga cagacctcaa taactctgtt taccagaaca ggaggtgagc 29280 ttagaaaacc cttagggtat taggccaaag gcgcagctac tgtggggttt atgaacaatt 29340 caagcaactc tacgggctat tctaattcag gtttctctag aatcggggtt ggggttattc 29400 tctgtcttgt gattctcttt attcttatac taacgcttct ctgcctaagg ctcgccgcct 29460 gctgtgtgca catttgcatt tattgtcagc tttttaaacg ctggggtcgc cacccaagat 29520 gattaggtac ataatcctag gtttactcac ccttgcgtca gcccacggta ccacccaaaa 29580 ggtggatttt aaggagccag cctgtaatgt tacattcgca gctgaagcta atgagtgcac 29640 cactcttata aaatgcacca cagaacatga aaagctgctt attcgccaca aaaacaaaat 29700 tggcaagtat gctgtttatg ctatttggca gccaggtgac actacagagt ataatgttac 29760 agttttccag ggtaaaagtc ataaaacttt tatgtatact tttccatttt atgaaatgtg 29820 cgacattacc atgtacatga gcaaacagta taagttgtgg cccccacaaa attgtgtgga 29880 aaacactggc actttctgct gcactgctat gctaattaca gtgctcgctt tggtctgtac 29940 cctactctat attaaataca aaagcagacg cagctttatt gaggaaaaga aaatgcctta 30000 atttactaag ttacaaagct aatgtcacca ctaactgctt tactcgctgc ttgcaaaaca 30060 aattcaaaaa gttagcatta taattagaat aggatttaaa ccccccggtc atttcctgct 30120 caataccatt cccctgaaca attgactcta tgtgggatat gctccagcgc tacaaccttg 30180 aagtcaggct tcctggatgt cagcatctga ctttggccag cacctgtccc gcggatttgt 30240 tccagtccaa ctacagcgac ccaccctaac agagatgacc aacacaacca acgcggccgc 30300 cgctaccgga cttacatcta ccacaaatac accccaagtt tctgcctttg tcaataactg 30360 ggataacttg ggcatgtggt ggttctccat agcgcttatg tttgtatgcc ttattattat 30420 gtggctcatc tgctgcctaa agcgcaaacg cgcccgacca cccatctata gtcccatcat 30480 tgtgctacac ccaaacaatg atggaatcca tagattggac ggactgaaac acatgttctt 30540 ttctcttaca gtatgattaa atgagacatg gccgttcagc tggtggaaag tggcgggggt 30600 tctgttcagg cgggcgggtc tctgaggctt acttgcgccg cgagtggtag aaccagtcgg 30660 agctacggaa tggggtggtt taggcaagct cccgggaaag aacgcgaatt tgtgagcggc 30720 attagctggc ggggcgattc cactgggtac gcagactctg taaagggaag gtttaccatc 30780 agccgcgata acgcaaagaa caccgttgat ctgcagatga atagcttgag accggaggac 30840 accgccatct actactgtgc agctgccgcc ggaagcacat ggtatgggac tctgtatgaa 30900 tacgactact ggggccaggg tacacaagtt accgtaagca gcggctctgg gtccggctcg 30960 accggagtgc aggtggaaac catctcccca ggagacgggc gcaccttccc caagcgcggc 31020 cagacctgcg tggtgcacta caccgggatg cttgaagatg gaaagaaatt tgattcctcc 31080 cgggacagaa acaagccctt taagtttatg ctaggcaagc aggaggtgat ccgaggctgg 31140 gaagaagggg ttgcccagat gagtgtgggt cagagagcca aactgactat atctccagat 31200 tatgcctatg gtgccactgg gcacccaggc atcatcccac cacatgccac tctcgtcttc 31260 gatgtggagc ttctaaaact gtaataaaaa aaaataataa agcatcactt acttaaaatc 31320 agttagcaaa tttctgtcca gtttattcag cagcacctcc ttgccctcct cccagctctg 31380 gtattgcagc ttcctcctgg ctgcaaactt tctccacaat ctaaatggaa tgtcagtttc 31440 ctcctgttcc tgtccatccg cacccactat cttcatgttg ttgcagatga agcgcgcaag 31500 accgtctgaa gataccttca accccgtgta tccatatgac acggaaaccg gtcctccaac 31560 tgtgcctttt cttactcctc cctttgtatc ccccaatggg tttcaagaga gtccccctgg 31620 ggtactctct ttgcgcctat ccgaacctct agttacctcc aatggcatgc ttgcgctcaa 31680 aatgggcaac ggcctctctc tggacgaggc cggcaacctt acctcccaaa atgtaaccac 31740 tgtgagccca cctctcaaaa aaaccaagtc aaacataaac ctggaaatat ctgcacccct 31800 cacagttacc tcagaagccc taactgtggc tgccgccgca cctctaatgg tcgcgggcaa 31860 cacactcacc atgcaatcac aggccccgct aaccgtgcac gactccaaac ttagcattgc 31920 cacccaagga cccctcacag tgtcagaagg aaagctagcc ctgcaaacat caggccccct 31980 caccaccacc gatagcagta cccttactat cactgcctca ccccctctaa ctactgccac 32040 tggtagcttg ggcattgact tgaaagagcc catttataca caaaatggaa aactaggact 32100 aaagtacggg gctcctttgc atgtaacaga cgacctaaac actttgaccg tagcaactgg 32160 tccaggtgtg actattaata atacttcctt gcaaactaaa gttactggag ccttgggttt 32220 tgattcacaa ggcaatatgc aacttaatgt agcaggagga ctaaggattg attctcaaaa 32280 cagacgcctt atacttgatg ttagttatcc gtttgatgct caaaaccaac taaatctaag 32340 actaggacag ggccctcttt ttataaactc agcccacaac ttggatatta actacaacaa 32400 aggcctttac ttgtttacag cttcaaacaa ttccaaaaag cttgaggtta acctaagcac 32460 tgccaagggg ttgatgtttg acgctacagc catagccatt aatgcaggag atgggcttga 32520 atttggttca cctaatgcac caaacacaaa tcccctcaaa acaaaaattg gccatggcct 32580 agaatttgat tcaaacaagg ctatggttcc taaactagga actggcctta gttttgacag 32640 cacaggtgcc attacagtag gaaacaaaaa taatgataag ctaactttgt ggaccacacc 32700 agctccatct cctaactgta gactaaatgc agagaaagat gctaaactca ctttggtctt 32760 aacaaaatgt ggcagtcaaa tacttgctac agtttcagtt ttggctgtta aaggcagttt 32820 ggctccaata tctggaacag ttcaaagtgc tcatcttatt ataagatttg acgaaaatgg 32880 agtgctacta aacaattcct tcctggaccc agaatattgg aactttagaa atggagatct 32940 tactgaaggc acagcctata caaacgctgt tggatttatg cctaacctat cagcttatcc 33000 aaaatctcac ggtaaaactg ccaaaagtaa cattgtcagt caagtttact taaacggaga 33060 caaaactaaa cctgtaacac taaccattac actaaacggt acacaggaaa caggagacac 33120 aactgagatg tggcatgaag gcctagaaga ggcctctcgc ttgtactttg gggagaggaa 33180 cgtcaaaggc atgtttgagg tgctggagcc cctgcatgct atgatggaac gcggtcccca 33240 gaccctgaag gaaacgtcct ttaatcaggc atatggtcga gatttaatgg aggcacaaga 33300 atggtgccga aagtacatga aatcagggaa cgtcaaggac ctcctccaag cctgggacct 33360 ctactatcac gtgttcagac gaatctcaaa gcagccaagt gcatactcta tgtcattttc 33420 atgggactgg tctggccaca actacattaa tgaaatattt gccacatcct cttacacttt 33480 ttcatacatt gcccaagaat aaagaatcgt ttgtgttatg tttcaacgtg tttatttttc 33540 aattgcagaa aatttcaagt catttttcat tcagtagtat agccccacca ccacatagct 33600 tatacagatc accgtacctc aactttgtat aataaagttg taatcaaact cacagaaccc 33660 tagtattcaa cctgccacct ccctcccaac acacagagta cacagtcctt tctccccggc 33720 tggccttaaa aagcatcata tcatgggtaa cagacatatt cttaggtgtt atattccaca 33780 cggtttcctg tcgagccaaa cgctcatcag tgatattaat aaactccccg ggcagctcac 33840 ttaagttcat gtcgctgtcc agctgctgag ccacaggctg ctgtccaact tgcggttgct 33900 taacgggcgg cgaaggagaa gtccacgcct acatgggggt agagtcataa tcgtgcatca 33960 ggatagggcg gtggtgctgc agcagcgcgc gaataaactg ctgccgccgc cgctccgtcc 34020 tgcaggaata caacatggca gtggtctcct cagcgatgat tcgcaccgcc cgcagcataa 34080 ggcgccttgt cctccgggca cagcagcgca ccctgatctc acttaaatca gcacagtaac 34140 tgcagcacag caccacaata ttgttcaaaa tcccacagtg caaggcgctg tatccaaagc 34200 tcatggcggg gaccacagaa cccacgtggc catcatacca caagcgcagg tagattaagt 34260 ggcgacccct cataaacacg ctggacataa acattacctc ttttggcatg ttgtaattca 34320 ccacctcccg gtaccatata aacctctgat taaacatggc gccatccacc accatcctaa 34380 accagctggc caaaacctgc ccgccggcta tacactgcag ggaaccggga ctggaacaat 34440 gacagtggag agcccaggac tcgtaaccat ggatcatcat gctcgtcatg atatcaatgt 34500 tggcacaaca caggcacacg tgcatacact tcctcaggat tacaagctcc tcccgcgtta 34560 gaaccatatc ccagggaaca acccattcct gaatcagcgt aaatcccaca ctgcagggaa 34620 gacctcgcac gtaactcacg ttgtgcattg tcaaagtgtt acattcgggc agcagcggat 34680 gatcctccag tatggtagcg cgggtttctg tctcaaaagg aggtagacga tccctactgt 34740 acggagtgcg ccgagacaac cgagatcgtg ttggtcgtag tgtcatgcca aatggaacgc 34800 cggacgtagt catatttcct gaagcaaaac caggtgcggg cgtgacaaac agatctgcgt 34860 ctccggtctc gccgcttaga tcgctctgtg tagtagttgt agtatatcca ctctctcaaa 34920 gcatccaggc gccccctggc ttcgggttct atgtaaactc cttcatgcgc cgctgccctg 34980 ataacatcca ccaccgcaga ataagccaca cccagccaac ctacacattc gttctgcgag 35040 tcacacacgg gaggagcggg aagagctgga agaaccatgt tttttttttt attccaaaag 35100 attatccaaa acctcaaaat gaagatctat taagtgaacg cgctcccctc cggtggcgtg 35160 gtcaaactct acagccaaag aacagataat ggcatttgta agatgttgca caatggcttc 35220 caaaaggcaa acggccctca cgtccaagtg gacgtaaagg ctaaaccctt cagggtgaat 35280 ctcctctata aacattccag caccttcaac catgcccaaa taattctcat ctcgccacct 35340 tctcaatata tctctaagca aatcccgaat attaagtccg gccattgtaa aaatctgctc 35400 cagagcgccc tccaccttca gcctcaagca gcgaatcatg attgcaaaaa ttcaggttcc 35460 tcacagacct gtataagatt caaaagcgga acattaacaa aaataccgcg atcccgtagg 35520 tcccttcgca gggccagctg aacataatcg tgcaggtctg cacggaccag cgcggccact 35580 tccccgccag gaaccatgac aaaagaaccc acactgatta tgacacgcat actcggagct 35640 atgctaacca gcgtagcccc gatgtaagct tgttgcatgg gcggcgatat aaaatgcaag 35700 gtgctgctca aaaaatcagg caaagcctcg cgcaaaaaag aaagcacatc gtagtcatgc 35760 tcatgcagat aaaggcaggt aagctccgga accaccacag aaaaagacac catttttctc 35820 tcaaacatgt ctgcgggttt ctgcataaac acaaaataaa ataacaaaaa aacatttaaa 35880 cattagaagc ctgtcttaca acaggaaaaa caacccttat aagcataaga cggactacgg 35940 ccatgccggc gtgaccgtaa aaaaactggt caccgtgatt aaaaagcacc accgacagct 36000 cctcggtcat gtccggagtc ataatgtaag actcggtaaa cacatcaggt tgattcacat 36060 cggtcagtgc taaaaagcga ccgaaatagc ccgggggaat acatacccgc aggcgtagag 36120 acaacattac agcccccata ggaggtataa caaaattaat aggagagaaa aacacataaa 36180 cacctgaaaa accctcctgc ctaggcaaaa tagcaccctc ccgctccaga acaacataca 36240 gcgcttccac agcggcagcc ataacagtca gccttaccag taaaaaagaa aacctattaa 36300 aaaaacacca ctcgacacgg caccagctca atcagtcaca gtgtaaaaaa gggccaagtg 36360 cagagcgagt atatatagga ctaaaaaatg acgtaacggt taaagtccac aaaaaacacc 36420 cagaaaaccg cacgcgaacc tacgcccaga aacgaaagcc aaaaaaccca caacttcctc 36480 aaatcgtcac ttccgttttc ccacgttacg tcacttccca ttttaagaaa actacaattc 36540 ccaacacata caagttactc cgccctaaaa cctacgtcac ccgccccgtt cccacgcccc 36600 gcgccacgtc acaaactcca ccccctcatt atcatattgg cttcaatcca aaataaggta 36660 tattattgat gatg 36674

Claims (69)

  1. 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 변형된 또는 결실된 E4orf6/7 단백질, 또는 이들의 임의의 조합을 암호화하는 게놈을 가지며, 종양 세포와 비교하여 정상 세포에서 복제 결함을 갖는, 재조합 아데노바이러스.
  2. 제1항에 있어서, 상기 게놈은 변형된 E1A 단백질, 및 변형된 또는 결실된 E4orf1 단백질을 암호화하는, 재조합 아데노바이러스.
  3. 제1항에 있어서, 상기 게놈은 변형된 E1A 단백질 및 결실된 E4orf6/7 단백질을 암호화하는, 재조합 아데노바이러스.
  4. 제1항에 있어서, 상기 게놈은 변형된 E1A 단백질, 변형된 또는 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질을 암호화하는, 재조합 아데노바이러스.
  5. 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 변형된 E1A 단백질은 하기를 포함하는, 재조합 아데노바이러스:
    LXCXE 모티프의 결실;
    2 내지 11 잔기의 결실;
    C124G 치환;
    Y47H 치환;
    Y47H 치환 및 C124G 치환; 또는
    Y47H 치환, C124G 치환 및 2 내지 11 잔기의 결실.
  6. 제1항, 제2항, 제4항 및 제5항 중 어느 한 항에 있어서, 상기 변형된 E4orf1 단백질은 PDZ-결합 모티프의 결실을 포함하는, 재조합 아데노바이러스.
  7. 제1항에 있어서, 상기 게놈이 하기를 암호화하는, 재조합 아데노바이러스:
    LXCXE 모티프의 결실을 포함하는 변형된 E1A 단백질 및 결실된 E4orf6/7 단백질;
    LXCXE 모티프의 결실을 포함하는 변형된 E1A 단백질, PDZ-결합 모티프의 결실을 포함하는 변형된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질;
    LXCXE 모티프의 결실을 포함하는 변형된 E1A 단백질, 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질;
    C124G 치환을 포함하는 변형된 E1A 단백질 및 결실된 E4orf6/7 단백질;
    C124G 치환을 포함하는 변형된 E1A 단백질, PDZ-결합 모티프의 결실을 포함하는 변형된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질;
    C124G 치환을 포함하는 변형된 E1A 단백질, 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질;
    2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질 및 결실된 E4orf6/7 단백질;
    2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질, PDZ-결합 모티프의 결실을 포함하는 변형된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질;
    2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질, 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질;
    Y47H 치환 및 C124G 치환을 포함하는 변형된 E1A 단백질, 및 결실된 E4orf6/7 단백질;
    Y47H 치환 및 C124G 치환을 포함하는 변형된 E1A 단백질, PDZ-결합 모티프의 결실을 포함하는 변형된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질;
    Y47H 치환 및 C124G 치환을 포함하는 변형된 E1A 단백질, 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질;
    Y47H 치환, C124G 치환 및 2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질, 및 결실된 E4orf6/7 단백질;
    Y47H 치환, C124G 치환 및 2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질, PDZ-결합 모티프의 결실을 포함하는 변형된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질; 또는
    Y47H 치환, C124G 치환 및 2 내지 11 잔기의 결실을 포함하는 변형된 E1A 단백질, 결실된 E4orf1 단백질, 및 결실된 E4orf6/7 단백질.
  8. 제7항에 있어서, 상기 게놈이 서열번호 6 내지 8, 10 내지 12, 14, 15, 18 내지 20 및 22 내지 24중 어느 하나의 뉴클레오티드 서열을 포함하는, 재조합 아데노바이러스.
  9. 제1항 내지 제7항 중 어느 한 항에 있어서, 상기 게놈이 FK506 결합 단백질(FKBP)에 융합된 표적화 리간드, 및 야생형 FRB(FKBP-rapamycin binding) 단백질 또는 T2098L 치환을 포함하는 돌연변이 FRB 단백질에 융합된 아데노바이러스 섬유 단백질을 추가로 암호화하는, 재조합 아데노바이러스.
  10. 제9항에 있어서, 상기 표적화 리간드가 단일 도메인 항체인, 재조합 아데노바이러스.
  11. 제10항에 있어서, 상기 단일 도메인 항체가 EGFR에 특이적인, 재조합 아데노바이러스.
  12. 제1항 내지 제7항 및 제9항 내지 제11항 중 어느 한 항에 있어서, 상기 게놈이 E3-RIDα/RIDβ 및 E3-14.7k 코딩서열의 결실을 포함하는, 재조합 아데노바이러스.
  13. 제9항 내지 제12항 중 어느 한 항에 있어서, 상기 게놈이 서열번호 25 또는 서열번호 26의 뉴클레오티드 서열을 포함하는, 재조합 아데노바이러스.
  14. 제1항 내지 제7항 및 제9항 내지 제12항 중 어느 한 항에 있어서, 상기 게놈이 변형된 헥손 단백질을 추가로 암호화하는, 재조합 아데노바이러스.
  15. 제14항에 있어서, 상기 변형된 헥손 단백질이 E451Q 치환을 포함하는, 재조합 아데노바이러스.
  16. 제14항 또는 제15항에 있어서, 상기 게놈이 서열번호 30, 서열번호 92 또는 서열번호 97의 뉴클레오티드 서열을 포함하는, 재조합 아데노바이러스.
  17. 제1항 내지 제7항 중 어느 한 항에 있어서, 상기 게놈이 T2098L 치환을 포함하는 돌연변이 FRB 단백질에 융합된 아데노바이러스 섬유 단백질을 추가로 암호화하는, 재조합 아데노바이러스.
  18. 제17항에 있어서, 상기 게놈이 E451Q 치환을 포함하는 변형된 헥손 단백질을 추가로 암호화하는, 재조합 아데노바이러스.
  19. 제17항 또는 제18항에 있어서, 상기 게놈이 서열번호 31의 뉴클레오티드 서열을 포함하는, 재조합 아데노바이러스.
  20. 제1항 내지 제19항 중 어느 한 항에 있어서, 상기 게놈이 간 특이적인 마이크로 RNA를 위한 하나 또는 그 이상의 결합 부위를 추가로 포함하는, 재조합 아데노바이러스.
  21. 제20항에 있어서, 상기 간 특이적인 마이크로 RNA를 위한 하나 또는 그 이상의 결합 부위가 E1A의 3'-UTR에 위치하는, 재조합 아데노바이러스.
  22. 제20항 또는 제21항에 있어서, 상기 간 특이적인 마이크로 RNA가 miR-122인, 재조합 아데노바이러스.
  23. 제1항 내지 제22항 중 어느 한 항에 있어서, 상기 게놈이 키메라(chimeric) 섬유 단백질을 암호화하는, 재조합 아데노바이러스.
  24. 제23항에 있어서, 상기 키메라 섬유 단백질이 제1 아데노바이러스 혈청형으로부터의 섬유 샤프트(shaft) 및 제2 아데노바이러스 혈청형으로부터의 섬유 노브(knob)를 포함하는, 재조합 아데노바이러스.
  25. 제24항에 있어서, 상기 제1 아데노바이러스 혈청형이 Ad5이고, 제2 아데노바이러스 혈청형이 Ad3, Ad9, Ad11, Ad12, Ad34 또는 Ad37인, 재조합 아데노바이러스.
  26. 제25항에 있어서, 상기 제1 아데노바이러스 혈청형이 Ad5이고, 제2 아데노바이러스 혈청형이 Ad11, Ad34 또는 Ad37인, 재조합 아데노바이러스.
  27. 제26항에 있어서, 상기 게놈이 서열번호 82, 서열번호 83 또는 서열번호 84의 뉴클레오티드 서열을 포함하는, 재조합 아데노바이러스.
  28. 제1항 내지 제27항 중 어느 한 항에 있어서, 상기 게놈이 캡시드가 교환된(capsid-swapped) 키메라 아데노바이러스를 암호화하는, 재조합 아데노바이러스.
  29. 제28항에 있어서, 상기 게놈의 E1, E3 및 E4 영역이 제1 아데노바이러스 혈청형으로부터 유래되고, 상기 게놈의 E2B, L1, L2, L3, E2A 및 L4 영역이 제2 아데노바이러스 혈청형으로부터 유래된, 재조합 아데노바이러스.
  30. 제29항에 있어서, 상기 제1 아데노바이러스 혈청형의 E1 영역이 제2 아데노바이러스 혈청형으로부터의 pIX 단백질을 암호화하도록 변형; 및/또는 상기 제1 아데노바이러스 혈청형의 E3 영역이 제2 아데노바이러스 혈청형으로부터의 U엑손(Uexon) 및 섬유 단백질을 암호화하도록 변형된, 재조합 아데노바이러스.
  31. 제29항 또는 제30항에 있어서, 상기 제1 아데노바이러스 혈청형이 Ad5이고, 제2 아데노바이러스 혈청형이 Ad3, Ad9, Ad11 또는 Ad34인, 재조합 아데노바이러스.
  32. 제31항에 있어서, 상기 게놈이 서열번호 85, 서열번호 92, 서열번호 97, 서열번호 93, 서열번호 94, 서열번호 95, 또는 서열번호 96의 뉴클레오티드 서열을 포함하는, 재조합 아데노바이러스.
  33. 제1항 내지 제32항 중 어느 한 항에 있어서, 상기 게놈이 변형된 펜톤(penton) 단백질을 추가로 암호화하는, 재조합 아데노바이러스.
  34. 제33항에 있어서, 상기 변형된 펜톤 단백질이 인테그린-결합 RGD 모티프에서의 돌연변이를 포함하는, 재조합 아데노바이러스.
  35. 제34항에 있어서, 상기 게놈이 서열번호 86 또는 서열번호 87의 뉴클레오티드 서열을 포함하는, 재조합 아데노바이러스.
  36. 제1항 내지 제35항 중 어느 한 항에 있어서, 상기 게놈이 RGD 펩티드를 포함하도록 변형된 섬유 단백질을 추가로 암호화하는, 재조합 아데노바이러스.
  37. 제36항에 있어서, 상기 게놈이 서열번호 87의 뉴클레오티드 서열을 포함하는, 재조합 아데노바이러스.
  38. 제1항 내지 제37항 중 어느 한 항의 재조합 아데노바이러스 및 약학적으로 허용가능한 담체를 포함하는 조성물.
  39. 제1항 내지 제37항 중 어느 한 항의 재조합 아데노바이러스 또는 제38항의 조성물과 종양세포를 접촉시키는 것을 포함하는 종양세포 생존능을 저해하는 방법.
  40. 제39항에 있어서, 상기 방법이 시험관 내(in vitro) 방법인, 방법.
  41. 제39항에 있어서, 상기 방법이 생체 내(in vivo) 방법이고, 상기 종양세포를 접촉시키는 것이 상기 재조합 아데노바이러스 또는 조성물을 종양을 갖는 대상에게 투여하는 것을 포함하는, 방법.
  42. 제1항 내지 제37항 중 어느 한 항의 재조합 아데노바이러스 또는 제38항의 조성물의 치료학적 유효량을 대상에게 투여하여 대상에서의 종양의 진행을 저해하거나 종양의 부피를 감소시키는 것을 포함하는 대상의 종양 진행을 저해하거나 종양 부피를 감소시키는 방법.
  43. 제1항 내지 제37항 중 어느 한 항의 재조합 아데노바이러스 또는 제38항의 조성물의 치료학적 유효량을 대상에게 투여하여 대상에서의 암을 치료하는 것을 포함하는 대상의 암을 치료하는 방법.
  44. 하기를 대상에게 투여하는 것을 포함하는 대상의 종양 부피를 감소시키는 방법:
    (i) 제9항 내지 제16항 중 어느 한 항의 재조합 아데노바이러스의 치료학적 유효량; 및
    (ii) 라파마이신 또는 이의 유사체.
  45. 하기를 대상에게 투여하는 것을 포함하는 대상의 암을 치료하는 방법:
    (i) 제9항 내지 제16항 중 어느 한 항의 재조합 아데노바이러스의 치료학적 유효량; 및
    (ii) 라파마이신 또는 이의 유사체.
  46. 제44항 또는 제45항에 있어서, 상기 라파마이신 또는 라파마이신 유사체가 약 0.1 mg/kg 내지 약 2.0 mg/kg의 투여량으로 투여되는, 방법.
  47. 제44항 또는 제45항에 있어서, 상기 라파마이신 또는 라파마이신 유사체가 약 0.1 mg/kg 내지 약 0.5 mg/kg의 투여량으로 투여되는, 방법.
  48. 제44항 또는 제45항에 있어서, 상기 라파마이신 또는 라파마이신 유사체가 약 1 내지 약 15 mg/m2의 투여량으로 투여되는, 방법.
  49. 제44항 또는 제45항에 있어서, 상기 라파마이신 또는 라파마이신 유사체가 약 3 내지 약 10 ng/mL의 투여량으로 투여되는, 방법.
  50. 제44항 내지 제49항 중 어느 한 항에 있어서, 상기 라파마이신 또는 라파마이신 유사체가 대상에서 상당한 면역억제를 일으키지 않는 투여량으로 투여되는, 방법.
  51. 제39항 내지 제50항 중 어느 한 항에 있어서, 상기 종양 또는 암이 E2F 경로의 탈조절에 의해 특징화되는, 방법.
  52. 제39항 내지 제51항 중 어느 한 항에 있어서, 상기 종양 또는 암이 폐, 전립선, 결장직장, 유방, 갑상선, 신장 또는 간 종양 또는 암, 또는 백혈병인, 방법.
  53. 제41항 내지 제52항 중 어느 한 항에 있어서, 추가적인 치료제로 상기 대상을 치료하는 것을 추가로 포함하는, 방법.
  54. 제53항에 있어서, 상기 추가적인 치료제가 면역 조절제를 포함하는, 방법.
  55. 제53항에 있어서, 상기 추가적인 치료제가 사이클린-의존성 키나아제(CDK) 저해제를 포함하는, 방법.
  56. 재조합 아데노바이러스의 게놈이 E1A의 결실을 포함하고, EF1α-루시퍼라제를 암호화하는, 재조합 아데노바이러스.
  57. 제56항에 있어서, 상기 게놈이 서열번호 27의 뉴클레오티드 서열을 포함하는, 재조합 아데노바이러스.
  58. 제56항에 있어서, 상기 게놈이 간 특이적인 마이크로 RNA를 위한 하나 또는 그 이상의 결합 부위를 추가로 포함하는, 재조합 아데노바이러스.
  59. 제58항에 있어서, 상기 간 특이적인 마이크로 RNA를 위한 하나 또는 그 이상의 결합 부위가 E1A의 3'-UTR에 위치하는, 재조합 아데노바이러스.
  60. 제58항 또는 제59항에 있어서, 상기 간 특이적인 마이크로 RNA가 miR-122인, 재조합 아데노바이러스.
  61. 제58항 내지 제60항 중 어느 한 항에 있어서, 상기 게놈이 서열번호 28의 뉴클레오티드 서열을 포함하는, 재조합 아데노바이러스.
  62. 제56항 및 제58항 내지 제61항 중 어느 한 항에 있어서, 상기 게놈이 변형된 헥손(hexon) 단백질을 코딩하는, 재조합 아데노바이러스.
  63. 제62항에 있어서, 상기 변형된 헥손 단백질이 E451Q 치환을 포함하는, 재조합 아데노바이러스.
  64. 제62항 또는 제63항에 있어서, 상기 게놈이 서열번호 29의 뉴클레오티드 서열을 포함하는, 재조합 아데노바이러스.
  65. 서열번호 1 내지 31 및 68 내지 98 중 어느 하나의 뉴클레오티드 서열을 포함하는 재조합 핵산 분자.
  66. 제65항에 있어서, 상기 뉴클레오티드 서열이 서열번호 1 내지 31 및 68 내지 98 중 어느 하나의 서열로 이루어지는, 재조합 핵산 분자.
  67. 제65항 또는 제66항의 핵산 분자를 포함하는 벡터.
  68. 제67항의 벡터를 포함하는 형질전환세포.
  69. 제9항 내지 제16항 중 어느 한 항의 재조합 아데노바이러스 및 라파마이신 또는 이의 유사체를 포함하는 키트.



KR1020177011121A 2014-09-24 2015-09-23 종양 살상 바이러스 및 이의 사용방법 Active KR102608590B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237040919A KR102814615B1 (ko) 2014-09-24 2015-09-23 종양 살상 바이러스 및 이의 사용방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462054724P 2014-09-24 2014-09-24
US62/054,724 2014-09-24
PCT/US2015/051745 WO2016049201A1 (en) 2014-09-24 2015-09-23 Oncolytic tumor viruses and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020237040919A Division KR102814615B1 (ko) 2014-09-24 2015-09-23 종양 살상 바이러스 및 이의 사용방법

Publications (2)

Publication Number Publication Date
KR20170063801A true KR20170063801A (ko) 2017-06-08
KR102608590B1 KR102608590B1 (ko) 2023-12-01

Family

ID=55581955

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020177011121A Active KR102608590B1 (ko) 2014-09-24 2015-09-23 종양 살상 바이러스 및 이의 사용방법
KR1020257017356A Pending KR20250081944A (ko) 2014-09-24 2015-09-23 종양 살상 바이러스 및 이의 사용방법
KR1020237040919A Active KR102814615B1 (ko) 2014-09-24 2015-09-23 종양 살상 바이러스 및 이의 사용방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020257017356A Pending KR20250081944A (ko) 2014-09-24 2015-09-23 종양 살상 바이러스 및 이의 사용방법
KR1020237040919A Active KR102814615B1 (ko) 2014-09-24 2015-09-23 종양 살상 바이러스 및 이의 사용방법

Country Status (11)

Country Link
US (1) US12514887B2 (ko)
EP (2) EP3198009B1 (ko)
JP (3) JP6764859B2 (ko)
KR (3) KR102608590B1 (ko)
CN (1) CN108064275A (ko)
AU (3) AU2015320665B2 (ko)
CA (1) CA2961748A1 (ko)
DK (1) DK3198009T3 (ko)
ES (1) ES2899913T3 (ko)
PL (1) PL3198009T3 (ko)
WO (1) WO2016049201A1 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201507393TA (en) 2013-03-14 2015-10-29 Salk Inst For Biological Studi Oncolytic adenovirus compositions
KR102608590B1 (ko) 2014-09-24 2023-12-01 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양 살상 바이러스 및 이의 사용방법
EP3359175B1 (en) * 2015-10-05 2020-09-16 Salk Institute for Biological Studies Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration
WO2017147269A1 (en) * 2016-02-23 2017-08-31 Salk Institute For Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
EP3532082A4 (en) * 2016-12-12 2020-08-26 Salk Institute for Biological Studies SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES
WO2018125970A1 (en) * 2016-12-30 2018-07-05 Salk Institute For Biological Studies Synthetic adenoviruses targeting bone tissue and uses thereof
CA3052090A1 (en) * 2017-01-30 2018-08-02 Epicentrx, Inc. Multiple transgene recombinant adenovirus
EA201990822A1 (ru) 2017-04-12 2020-01-09 Эписентарикс, Инк. Иммуномодулирующие слитые белки
EP3773649A4 (en) 2018-03-28 2022-02-23 EpicentRx, Inc. PERSONALIZED CANCER VACCINE
CN112292449A (zh) * 2018-04-09 2021-01-29 萨克生物研究学院 具有增强的复制特性的溶瘤腺病毒组合物
CN111363726A (zh) 2018-12-26 2020-07-03 上海元宋生物技术有限公司 表达干扰素的溶瘤病毒及其应用
EP3927833A4 (en) 2019-02-21 2022-11-30 Unleash Immuno Oncolytics, Inc. ONCOLYTIC ADENOVIRAL VECTOR AND METHODS OF USE
KR20220079551A (ko) * 2019-09-05 2022-06-13 클리니쿰 레히츠 데어 이자르 데어 테크니쉔 우니베르지테트 뮌헨 종양 세포 붕괴성 아데노바이러스, cdk4/6 억제제 및 추가의 치료 활성제의 조합물에 의한 종양의 치료
EP3812465A1 (en) 2019-10-21 2021-04-28 Universität Ulm Adenovirus comprising a modified adenovirus hexon protein
KR20220153581A (ko) * 2020-02-14 2022-11-18 솔크 인스티튜트 포 바이올로지칼 스터디즈 Ulk1/2 의 억제제 및 이의 사용 방법
KR20220153582A (ko) 2020-02-14 2022-11-18 솔크 인스티튜트 포 바이올로지칼 스터디즈 마크로시클릭 ulk1/2 억제제
CA3188127A1 (en) * 2020-07-06 2022-01-13 Salk Institute For Biological Studies Oncolytic adenovirus with replication selectivity based on status of p53 transcriptional activity
US20240247283A1 (en) * 2021-05-06 2024-07-25 Asimov Inc. Compositions and methods for adeno-associated viral production

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012024351A2 (en) * 2010-08-16 2012-02-23 Salk Institute For Biological Studies Adenoviral assembly method

Family Cites Families (333)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670488A (en) * 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
US6410010B1 (en) 1992-10-13 2002-06-25 Board Of Regents, The University Of Texas System Recombinant P53 adenovirus compositions
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
ATE178490T1 (de) 1993-02-16 1999-04-15 Onyx Pharmaceuticals Cytopathische viren zur therapie und prophylaxe der neoplasie
US5801029A (en) 1993-02-16 1998-09-01 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US7045347B2 (en) 1993-06-24 2006-05-16 Advec, Inc. Helper dependent adenovirus vectors based on integrase family site-specific recombinases
US5543328A (en) 1993-08-13 1996-08-06 Genetic Therapy, Inc. Adenoviruses having modified fiber proteins
US20010006629A1 (en) 1993-10-25 2001-07-05 Richard J. Gregory Recombinant adenoviral vector and methods of use
US7252989B1 (en) 1994-04-04 2007-08-07 Board Of Regents, The University Of Texas System Adenovirus supervector system
US5559099A (en) 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US5965541A (en) 1995-11-28 1999-10-12 Genvec, Inc. Vectors and methods for gene transfer to cells
US5962311A (en) 1994-09-08 1999-10-05 Genvec, Inc. Short-shafted adenoviral fiber and its use
US6465253B1 (en) 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
FR2726285B1 (fr) 1994-10-28 1996-11-29 Centre Nat Rech Scient Adenovirus depourvus de particules contaminantes viables, preparation et utilisation
WO1996018418A1 (en) 1994-12-12 1996-06-20 Genetic Therapy, Inc. Improved adenoviral vectors and producer cells
US6127525A (en) 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US5770442A (en) 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
US20030026789A1 (en) 1995-05-03 2003-02-06 Richard J. Gregory Gene therapy using replication competent targeted adenoviral vectors
US6506379B1 (en) 1995-06-07 2003-01-14 Ariad Gene Therapeutics, Inc. Intramuscular delivery of recombinant AAV
AUPN477695A0 (en) 1995-08-14 1995-09-07 Commonwealth Scientific And Industrial Research Organisation Gene therapy
US5945335A (en) 1995-11-09 1999-08-31 Avigen, Inc. Adenovirus helper-free system for producing recombinant AAV virions lacking oncogenic sequences
DE69634489T2 (de) 1995-11-13 2006-02-16 Commissariat à l'Energie Atomique Adenovirus dodekahedrischer proteinkomplex, dieser enthaltende zusammensetzung und verwendungen davon
EE9800160A (et) 1995-11-28 1998-12-15 Genvec, Inc. Vektorid ja meetodid geenide ülekandmiseks rakkudesse
US6133243A (en) 1996-02-22 2000-10-17 Onyx Pharmaceuticals, Inc. Liposomal-viral DNA complexes for treating disease
FR2746110B1 (fr) 1996-03-14 1998-04-17 Methode de traitement par therapie genique des tumeurs humaines et virus recombinants correspondants
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
IL127692A0 (en) 1996-07-01 1999-10-28 Rhone Poulenc Rorer Sa Method for producing recombinant adenovirus
US7232899B2 (en) 1996-09-25 2007-06-19 The Scripps Research Institute Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use
US5922315A (en) 1997-01-24 1999-07-13 Genetic Therapy, Inc. Adenoviruses having altered hexon proteins
US6403370B1 (en) 1997-02-10 2002-06-11 Genstar Therapeutics Corporation Oncolytic/immunogenic complementary-adenoviral vector system
US20050287120A1 (en) 1997-03-21 2005-12-29 Fisher Paul B Cancer - targeted viral vectors
FR2761689B1 (fr) 1997-04-02 1999-06-25 Transgene Sa Fibre adenovirale modifiee et adenovirus cibles
CA2291323A1 (en) 1997-05-28 1998-12-03 Genvec, Inc. Alternatively targeted adenovirus
US6200799B1 (en) 1997-06-03 2001-03-13 University Of Lausanne Somatic gene therapy to suppress secondary cataract formation following eye surgery
EP0996735B1 (en) 1997-06-09 2003-12-10 Genvec, Inc. Chimeric vectors comprising a phage packaging site and a portion derived from the genome of a eukaryotic virus
AU751259B2 (en) 1997-12-12 2002-08-08 Onyx Pharmaceuticals, Inc. Selective killing and diagnosis of p53+ neoplastic cells
IL137681A0 (en) 1998-02-06 2001-10-31 Uab Research Foundation Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob
US6984635B1 (en) 1998-02-13 2006-01-10 Board Of Trustees Of The Leland Stanford Jr. University Dimerizing agents, their production and use
AU751542B2 (en) 1998-02-17 2002-08-22 Uab Research Foundation, The Modified adenovirus containing a fiber replacement protein
US20050095231A1 (en) 1998-02-17 2005-05-05 Curiel David T. Modified adenovirus containing a fiber replacement protein
WO1999044423A1 (en) 1998-03-03 1999-09-10 The Uab Research Foundation Amplification of gene transfer and gene therapy by controlled replication
AU3358999A (en) 1998-03-20 1999-10-11 Genzyme Corporation Chimeric adenoviral vectors for targeted gene delivery
US6670188B1 (en) 1998-04-24 2003-12-30 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
US7829329B2 (en) 1998-04-24 2010-11-09 Onyx Pharmaceuticals, Inc. Adenoviral vectors for treating disease
ES2180258T3 (es) 1998-07-07 2003-02-01 Transgene Sa Utilizacion de pautas de lectura abierta adenovirales de e4 para mejorar la expresion de genes.
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
CN1257286C (zh) 1998-08-27 2006-05-24 森泰莱昂公司 用于递送异源基因的定向腺病毒载体
US6900049B2 (en) 1998-09-10 2005-05-31 Cell Genesys, Inc. Adenovirus vectors containing cell status-specific response elements and methods of use thereof
US6455314B1 (en) 1998-09-11 2002-09-24 Genvec, Inc. Alternatively targeted adenovirus
US6841540B1 (en) 1998-09-29 2005-01-11 The Uab Research Foundation Immunomodulation by genetic modification of dendritic cells and B cells
IL142337A0 (en) 1998-10-15 2002-03-10 Canji Inc Selectively replicating viral vectors
US20020037274A1 (en) 1998-10-26 2002-03-28 Angelica Williams Single agent method for killing tumor and tumor associated endothelial cells using adenoviral mutants
US6929946B1 (en) 1998-11-20 2005-08-16 Crucell Holland B.V. Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
EP1141357A1 (en) 1999-01-14 2001-10-10 Novartis AG Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use
US6395875B1 (en) 1999-01-25 2002-05-28 Brookhaven Science Associates Llc Recombinant soluble adenovirus receptor
US7157266B2 (en) 1999-01-25 2007-01-02 Brookhaven Science Associates Llc Structure of adenovirus bound to cellular receptor car
AU776067B2 (en) 1999-03-04 2004-08-26 Crucell Holland B.V. Means and methods for fibroblast-like or macrophage-like cell transduction
US6869936B1 (en) 1999-03-04 2005-03-22 Crucell Holland B.V. Means and methods for fibroblast-like or macrophage-like cell transduction
US20040175362A1 (en) 1999-05-12 2004-09-09 Curiel David T. Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
ATE540686T1 (de) 1999-05-12 2012-01-15 Uab Research Foundation Adenovirus mit erhöhter infektiosität und konditionaler replikationsfähigkeit und deren verwendungen
ES2372823T3 (es) 1999-05-17 2012-01-26 Crucell Holland B.V. Adenovirus recombinante del serotipo ad11.
US20050232900A1 (en) 1999-05-18 2005-10-20 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
WO2003104467A1 (en) 2002-04-25 2003-12-18 Crucell Holland B.V. Means and methods for the production of adenovirus vectors
US7094398B1 (en) 1999-06-01 2006-08-22 University Of Washington Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration
EP1181382B1 (en) 1999-06-01 2005-03-23 The University of Washington Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration
EP1593742A3 (en) 1999-06-01 2006-02-01 The University of Washington Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
DE19929569A1 (de) 1999-06-21 2000-12-28 Holm Per Sonne Mittel zur Behandlung maligner Erkrankungen unter Verwendung des Proteins YB-1
WO2001002431A1 (en) 1999-07-06 2001-01-11 Got-A-Gene Ab Recombinant adenovirus
US7589069B1 (en) 1999-07-12 2009-09-15 Saint Louis University Replication-competent anti-cancer vectors
AU779892B2 (en) 1999-08-27 2005-02-17 European Molecular Biology Laboratory Modified adenoviral fibre and uses thereof
AU1070901A (en) 1999-09-23 2001-04-24 Genvec, Inc. Method of treating cells of the prostate prophylactically or therapeutically
EP1214098B1 (en) 1999-09-24 2006-11-22 The Uab Research Foundation Capsid-modified recombinant adenovirus and methods of use
AU1190901A (en) 1999-09-30 2001-04-30 Trustees Of The University Of Pennsylvania, The Replication selective adenoviruses for use in cancer therapy
AU1087701A (en) 1999-10-15 2001-04-30 Canji, Inc. Targeted vectors
BR0015491A (pt) 1999-11-12 2002-10-15 Oncolytics Biotech Inc Métodos para tratar um distúrbio proliferativo celular mediado por ras em um mamìfero, para tratar um neoplasma tendo uma via-ras ativada em um humano, para inibir metástase de um neoplasma tendo uma via-ras ativada em um mamìfero, e para tratar um neoplasma suspeito de ter uma via-ras ativada em um mamìfero, composição farmacêutica, kit, e, método para tratar uma população de células compreendendo um neoplasma suspeito de ter uma via-ras ativada in vitro
CN1382218A (zh) 1999-11-15 2002-11-27 昂尼克斯药物公司 溶瘤腺病毒
US6867022B1 (en) 2000-01-21 2005-03-15 Regents Of The University Of Michigan Replication deficient adenovirus vectors and methods of making and using them
AU2001234981A1 (en) 2000-02-09 2001-08-20 Genvec, Inc. Adenoviral capsid containing chimeric protein ix
US6911200B2 (en) 2000-03-24 2005-06-28 Cell Genesys, Inc. Methods of treating neoplasia with combination of target-cell specific adenovirus, chemotherapy and radiation
US6692736B2 (en) 2000-03-24 2004-02-17 Cell Genesys, Inc. Cell-specific adenovirus vectors comprising an internal ribosome entry site
WO2001073093A2 (en) 2000-03-24 2001-10-04 Cell Genesys, Inc. Cell-specific adenovirus vectors comprising an internal ribosome entry site
US20030082146A1 (en) 2000-04-26 2003-05-01 Van Es Helmuth H. G. Adenovirus vectors with knobless fibers, and their uses
AU2001295193A1 (en) 2000-05-01 2001-11-12 Novartis Ag Vectors for ocular transduction and use thereof for genetic therapy
US7332337B2 (en) 2000-05-16 2008-02-19 Galapagos Nv Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells
EP1157999A1 (en) 2000-05-24 2001-11-28 Introgene B.V. Methods and means for enhancing skin transplantation using gene delivery vehicles having tropism for primary fibroblasts, as well as other uses thereof
US7445929B2 (en) 2000-05-26 2008-11-04 Dainippon Sumitomo Pharma Co., Ltd. Recombinant adenovirus vector having a reduced side effect
WO2001092549A2 (en) 2000-05-31 2001-12-06 Genvec, Inc. Method and composition for targeting an adenoviral vector
AU6368901A (en) 2000-05-31 2001-12-11 Univ Saskatchewan Modified bovine adenovirus having altered tropism
US7754201B2 (en) 2000-06-02 2010-07-13 GenPhar, Inc Method of vaccination through serotype rotation
EP1167533A1 (en) 2000-06-23 2002-01-02 Vereniging Voor Christelijk Wetenschappelijk Onderwijs Methods and means for the complementation of viral protein expression in stable cell lines
US6579522B1 (en) 2000-06-27 2003-06-17 Genvec, Inc. Replication deficient adenoviral TNF vector
US7022496B2 (en) 2000-07-14 2006-04-04 The Johns Hopkins University Use of gene product of adenovirus early region 4 ORF-6 to inhibit repair of double-strand breaks in DNA
US20020106382A1 (en) 2000-07-14 2002-08-08 Young Charles S.H. Modified adenovirus and uses thereof
GB0017720D0 (en) 2000-07-19 2000-09-06 Got A Gene Ab Modified virus
WO2002012523A2 (en) 2000-08-10 2002-02-14 Crucell Holland B.V. Transduction of chondrocytes using adenoviral vectors
DE60138403D1 (de) 2000-09-26 2009-05-28 Crucell Holland Bv Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten
AU2715302A (en) 2000-12-08 2002-06-18 Invitrogen Corp Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US20030095989A1 (en) 2000-12-18 2003-05-22 Irving John M. Chimeric cytolytic viruses for cancer treatment
US6635466B2 (en) 2001-01-09 2003-10-21 University Of Iowa Research Foundation Adenovirus serotype 30 (Ad30)
AU2002250081A1 (en) 2001-02-14 2002-08-28 Uab Research Foundation Combined transductional and transcriptional targeting system for improved gene delivery
IL152420A0 (en) 2001-02-23 2003-05-29 Novartis Ag Novel oncolytic adenoviral vectors
WO2002079507A2 (de) 2001-04-02 2002-10-10 Bayer Aktiengesellschaft Verfahren zur spezifischen detektion, isolation und charakterisierung von zellen aus körperproben durch transfektion von nukleinsäurekonstrukten
US20030219899A1 (en) 2001-04-17 2003-11-27 Nikolay Korokhov Mosaic adenoviral vectors
US20030138405A1 (en) 2001-04-17 2003-07-24 Juan Fueyo Conditionally replicative adenovirus to target the Rb and Rb-related pathways
EP1390476A4 (en) 2001-04-17 2005-03-30 Vectorlogics Inc MOSAIC adenovirus vectors
EP1409748B1 (en) 2001-06-22 2011-10-26 The Trustees of The University of Pennsylvania Recombinant Adenoviruses comprising simian adenovirus proteins and uses thereof.
US6844192B2 (en) 2001-06-29 2005-01-18 Wake Forest University Adenovirus E4 protein variants for virus production
US6905678B2 (en) 2001-07-07 2005-06-14 Crucell Holland B.V. Gene delivery vectors with cell type specificity for mesenchymal stem cells
WO2003010306A1 (en) 2001-07-23 2003-02-06 Onyx Pharmaceuticals, Inc. Viral mutants that selectively replicate in targeted human cancer cells
WO2003025161A1 (en) 2001-09-18 2003-03-27 Clontech Laboratories, Inc. Site-specific recombinase based method for producing adenoviral vectors
US7569217B2 (en) 2001-09-24 2009-08-04 University Of Saskatchewan Porcine adenovirus E1 and E4 regions
WO2003029448A1 (en) 2001-09-29 2003-04-10 Yun, Chae-Ok Recombinant adenovirus with enhanced therapeutic effect and pharmaceutical composition comprising said recombinant adenovirus
AU2002365366B2 (en) 2001-11-21 2007-05-10 The Trustees Of The University Of Pennsylvania Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
CN100475966C (zh) 2001-11-23 2009-04-08 上海三维生物技术有限公司 具有肿瘤细胞特异性感染和转基因表达能力的新型腺病毒
EP1327688A1 (en) 2002-01-14 2003-07-16 Vereniging Voor Christelijk Wetenschappelijk Onderwijs Adenoviruses with enhanced lytic potency
EP1516055A4 (en) 2002-01-24 2007-08-08 Scripps Research Inst FIBER OPERATING MODIFICATIONS FOR EFFICIENT TARGETS
CA2474777A1 (en) 2002-02-01 2003-08-07 Transgene S.A. Adenoviral vectors for modulating the cellular activities associated with pods
US20030220284A1 (en) 2002-02-22 2003-11-27 Patricia Yotnda Delivery of adenoviral DNA in a liposomal formulation for treatment of disease
US20040005710A1 (en) 2002-03-09 2004-01-08 Ho-Sun Son Method for producing recombinant viruses using site-specific recombination
WO2003080083A1 (es) 2002-03-26 2003-10-02 Oncolytics Biotech Inc. Uso de adenovirus mutados en los genes va para el tratamiento del cancer
US20060147420A1 (en) 2004-03-10 2006-07-06 Juan Fueyo Oncolytic adenovirus armed with therapeutic genes
AU2003223089A1 (en) 2002-04-29 2003-11-17 Hadasit Medical Research Services And Development Company Ltd. Compositions and methods for treating cancer with an oncolytic viral agent
JP2005536231A (ja) 2002-05-08 2005-12-02 イントロン，インコーポレーテッド アデノウイルスに細胞選択的複製をもたらすための、スプライセオソーム媒介型ｒｎａトランススプライシングの使用
JP5213298B2 (ja) 2002-05-27 2013-06-19 ホルム，ペル・ゾンネ アデノウイルスおよびそれをコードしている核酸の新たな使用
US20060228334A1 (en) 2002-07-10 2006-10-12 Manuel Rosa-Calatrava Modified adenoviral fiber with ablated to cellular receptors
JP2005532829A (ja) 2002-07-18 2005-11-04 インヴィトロジェン コーポレーション 組換え部位を含むウイルスベクター
US7364727B2 (en) 2002-07-22 2008-04-29 Cell Genesys, Inc. Metastatic colon cancer specific promoter and uses thereof
US20040106194A1 (en) 2002-08-22 2004-06-03 Bett Andrew J. Methods for propagating adenovirus and virus produced thereby
WO2004031357A2 (en) 2002-10-01 2004-04-15 Duke University Targeted tumor therapy by use of recombinant adenovirus vectors that selectively replicate in hypoxic regions of tumors
EP1413586A1 (en) 2002-10-21 2004-04-28 Centre National De La Recherche Scientifique (Cnrs) Regulation of the Cre recombinase using a dissociation/re-association system of said recombinase
US20040102382A1 (en) 2002-11-27 2004-05-27 Transgene, S.A. Targeting peptides
US20080124360A1 (en) 2003-01-24 2008-05-29 Seggern Daniel J Von Adenovirus particles with enhanced infectivity of dendritic cells and particles with decreased infectivity of hepatocytes
US20040185555A1 (en) 2003-03-17 2004-09-23 Emini Emilio A. Adenovirus serotype 24 vectors, nucleic acids and virus produced thereby
US20040191761A1 (en) 2003-03-27 2004-09-30 Routes John M. Modified adenoviral E1A constructs and methods of use thereof
WO2004087930A1 (en) 2003-03-28 2004-10-14 Saint Louis University Adenovirus replication-competent vectors expressing trail
CN1759177A (zh) 2003-03-28 2006-04-12 麦克公司 腺病毒血清型34载体,核酸及其由此产生的病毒
US20050095705A1 (en) 2003-04-15 2005-05-05 Michael Kadan Method for production of oncolytic adenoviruses
US20060281090A1 (en) 2003-05-01 2006-12-14 University Of Washington Uw Tech Transfer- Invention Licensing Capsid-modified adenovirus vectors and methods of using the same
JP2007503843A (ja) 2003-05-14 2007-03-01 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー アデノウイルス親和性の拡大
US20050079158A1 (en) 2003-06-05 2005-04-14 Shenzhen Allucks Biotech Co., Ltd. Construct of anti-cancer recombinant adenovirus, method for preparing the same and use thereof
EP1631582A2 (en) 2003-06-10 2006-03-08 University of Saskatchewan Chimeric adenovirus capsid proteins
WO2004111251A2 (en) 2003-06-11 2004-12-23 The Scripps Research Institute Modified fiber proteins for efficient receptor binding
US7291498B2 (en) 2003-06-20 2007-11-06 The Trustees Of The University Of Pennsylvania Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
CA2528511C (en) 2003-06-20 2015-11-03 The Trustees Of The University Of Pennsylvania Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
US20050036989A1 (en) 2003-07-18 2005-02-17 Onyx Pharmaceuticals, Inc. Subgroup B adenoviral vectors for treating disease
WO2005012537A2 (en) 2003-07-25 2005-02-10 Genvec, Inc. Adenoviral vector-based vaccines
AU2003265873A1 (en) 2003-08-28 2005-04-14 Cell Genesys, Inc. Oncolytic adenoviral vectors encoding gm-csf
US20050186178A1 (en) 2003-08-28 2005-08-25 Ennist David L. Oncolytic adenoviral vectors encoding GM-CSF
EP1664099A2 (en) 2003-09-09 2006-06-07 Niels Rudi Pedersen Adenoviral epitopes
US7482156B2 (en) 2003-10-15 2009-01-27 Cell Genesys, Inc. Hepatocellular carcinoma specific promoter and uses thereof
CA2546178A1 (en) 2003-11-14 2005-06-09 Per Sonne Holm New use of adenovirus and nucleic acids coding therefor
WO2005048950A2 (en) 2003-11-17 2005-06-02 Biomune, Inc. Tumor and infectious disease therapeutic compositions
WO2005065348A2 (en) * 2003-12-31 2005-07-21 Kalobios, Inc. Transactivation system for mammalian cells
WO2005075506A1 (en) 2004-01-09 2005-08-18 The Scripps Research Institute Identification of endogenous trimerization domains in the adenovirus fiber protein that allow detargeting and retargeting of viral vectors
DE602005017743D1 (de) 2004-01-23 2009-12-31 Angeletti P Ist Richerche Bio Impfstoffträger für schimpansen-adenovirus
US20050201936A1 (en) 2004-02-12 2005-09-15 Wold William S.M. Models for viral-based cancer therapy
US7473418B2 (en) * 2004-03-25 2009-01-06 Cell Genesys, Inc. Pan cancer oncolytic vectors and methods of use thereof
EP1729817B1 (en) 2004-03-30 2014-03-05 Industry-Academic Cooperation Foundation Gene delivery system containing relaxin gene and pharmaceutical composition using relaxin
US20080292592A1 (en) 2004-04-30 2008-11-27 Sunil Chada Oncolytic Adenovirus Armed with Therapeutic Genes
WO2005106046A1 (en) 2004-05-03 2005-11-10 Stefan Kochanek Modified viral vector particles
GB0411428D0 (en) 2004-05-21 2004-06-23 Got A Gene Ab Vectors
BRPI0510475B8 (pt) 2004-05-26 2021-05-25 Bayer Pharma AG adenovírus quimérico recombinante, uso do mesmo no tratamento de câncer e métodos de inibição de crescimento de uma célula de câncer, de fornecimento de uma proteína terapêutica a uma célula e para o isolamento do adenovírus
US20050271622A1 (en) 2004-06-03 2005-12-08 Shenzhen Allucks Biotech Co., Ltd. Construct of tumor-selective recombinant adenovirus, method for preparing the same and use thereof
WO2005117993A2 (en) 2004-06-04 2005-12-15 Genvec, Inc. Method of using adenoviral vectors with improved safety and efficacy for the treatment of cancer
CN100361710C (zh) 2004-06-07 2008-01-16 成都康弘生物科技有限公司 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用
US20060292682A1 (en) 2004-07-22 2006-12-28 Hawkins Lynda K Addition of transgenes into adenoviral vectors
GB0416487D0 (en) 2004-07-23 2004-08-25 Isis Innovation Modified virus
US7776322B2 (en) 2004-08-16 2010-08-17 Stefan Kochanek Modified viral vector particles
EP1784493A2 (en) 2004-09-01 2007-05-16 The Government of the United States of America as Represented by The Department of Health and Human Services Adenoviral vectors able to transduce apcs, potential use in immune response generation
US7943373B2 (en) 2004-09-29 2011-05-17 Oncolys Biopharma, Inc. Telomelysin/GFP-expressing recombinant virus
AP2351A (en) 2004-10-13 2012-01-25 Crucell Holland Bv Improved adenoviral vectors and uses thereof.
US20070122817A1 (en) 2005-02-28 2007-05-31 George Church Methods for assembly of high fidelity synthetic polynucleotides
RU2007119313A (ru) 2004-10-25 2008-11-27 Новартис АГ (CH) Полинуклеотиды и полипептиды torc и способы применения
IL166049A0 (en) 2004-12-30 2006-01-15 Gavish Galilee Bio Appl Ltd Method for obtaining modified proteins and viruseswith intact native binding
SG158133A1 (en) 2004-12-31 2010-01-29 Sonne Holm Method for reversing multiple resistance in animal cells
US20090232800A1 (en) 2004-12-31 2009-09-17 Per Sonne Holm E1-minus adenoviruses and use thereof
WO2006086357A2 (en) 2005-02-10 2006-08-17 Merck & Co., Inc. Adenovirus serotype 36 vectors, nucleic acid and viruses produced thereby
JP2008538894A (ja) 2005-02-11 2008-11-13 メルク エンド カムパニー インコーポレーテッド アデノウイルス血清型２６ベクター、核酸およびそれにより製造されたウイルス
KR100747646B1 (ko) 2005-02-25 2007-08-08 연세대학교 산학협력단 데코린 유전자를 포함하는 유전자 전달 시스템 및 이를 포함하는 약제학적 항종양 조성물
WO2006119449A2 (en) 2005-05-04 2006-11-09 Vectorlogics, Inc. Modified adenovirus containing a stabilized antibody
WO2007050128A2 (en) 2005-05-31 2007-05-03 Vectorlogics, Inc. Shielded adenoviral vectors and methods of use
WO2006133911A2 (en) 2005-06-17 2006-12-21 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hepatitis c virus nucleic acid vaccine
BRPI0615400A2 (pt) 2005-08-31 2011-05-17 Genvec Inc vacinas para malária baseadas em vetor adenoviral
KR100723009B1 (ko) 2005-11-30 2007-05-29 한국원자력연구원 인간 ｐ３１ 유전자를 함유하는 악성 종양 치료용 약학적조성물
ES2304281B1 (es) 2006-02-01 2009-08-12 Dnatrix Inc. Adenovirus oncoliticos para el tratamiento del cancer.
WO2007094653A1 (en) 2006-02-13 2007-08-23 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg Adenovirus particles having a chimeric adenovirus spike protein, use thereof and methods for producing such particles.
WO2007103825A2 (en) 2006-03-02 2007-09-13 The Board Of Regents Of The University Of Texas System Combination therapy with oncolytic adenovirus
US20070292954A1 (en) 2006-04-21 2007-12-20 The Brigham And Women's Hospital, Inc. Generation of recombinant DNA by sequence-and ligation-independent cloning
EP2012822B1 (en) 2006-04-28 2010-01-20 The Trustees of the University of Pennsylvania Modified adenovirus hexon protein and uses thereof
US20080242608A1 (en) 2006-06-02 2008-10-02 Azad Bonni Methods and compositions for treating and preventing neurologic disorders
WO2007148148A1 (en) 2006-06-19 2007-12-27 Institut Gustave Roussy Inhibition of the liver tropism of adenoviral vectors
JP2008048621A (ja) 2006-08-22 2008-03-06 Chiba Prefecture キメラ型アデノウイルスとその作製方法並びにそれを用いた医薬
GR20060100496A (el) 2006-09-01 2008-04-15 Παρθενιος Μπουλικας ΛΙΠΟΣΩΜΑΤΙΚΑ ΕΓΚΑΨΥΛΙΩΜΕΝΟΙ ΦΟΡΕΙΣ-ΥΒΡΙΔΙΟΥ ΑΔΕΝΟΙΟΥ - ΙΟΥ SEMLIKI FOREST (SFV), ΠΟΥ ΦΕΡΕΙ ΚΑΤΑΣΚΕΥΑΣΜΑΤΑ RNAi ΚΑΙ ΘΕΡΑΠΕΥΤΙΚΑ ΓΟΝΙΔΙΑ ΠΟΥ ΧΡΗΣΙΜΟΠΟΙΟΥΝΤΑΙ ΕΝΑΝΤΙΟΝ ΣΤΟΧΩΝ ΚΑΡΚΙΝΟΥ ΚΑΙ ΑΛΛΩΝ ΑΣΘΕΝΕΙΩΝ
US20100098668A1 (en) 2006-09-29 2010-04-22 Northshore University Health System Oncolytic Adenoviruses and Uses Thereof
US20100272753A1 (en) 2006-10-26 2010-10-28 The Johns Hopkins University Recombinant Adenovirus Vaccines
EP2118102B1 (en) 2006-11-28 2013-06-12 Nerviano Medical Sciences S.r.l. Tricyclic indoles and (4,5-dihydro) indoles
WO2008095168A2 (en) 2007-02-01 2008-08-07 University Of Chicago Compositions and methods related to a recombinant adenoviral vector that targets il 13 receptors
JP5746823B2 (ja) 2007-03-14 2015-07-08 インスティトゥト カタラ ドンコロジア Ｅ３−１９ｋタンパク質の小胞体保持ドメインに突然変異を有するアデノウイルス及び癌治療におけるその用途
US20090081639A1 (en) 2007-05-31 2009-03-26 Phil Hill Assay for sensitivity to chemotherapeutic agents
WO2009065800A1 (en) 2007-11-20 2009-05-28 Crucell Holland B.V. Recombinant human adenoviruses for eliciting mucosal immune responses
CN102131920B (zh) 2007-11-28 2013-11-06 宾夕法尼亚大学托管会 猿猴亚家族C腺病毒SAdV-40、-31和-34及其应用
AU2008331905B2 (en) 2007-11-28 2014-09-18 The Trustees Of The University Of Pennsylvania Simian subfamily B adenovirus SAdV-28 and uses thereof
CN101883858B (zh) 2007-11-28 2015-07-22 宾夕法尼亚大学托管会 猿猴亚家族E腺病毒SAdV-39、-25.2、-26、-30、-37和-38及其应用
WO2009098492A2 (en) 2008-02-07 2009-08-13 Andrew Baker Modulation of adenoviral tropism
JP5661476B2 (ja) 2008-03-04 2015-01-28 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア サルアデノウイルスＳＡｄＶ−３６、−４２．１、−４２．２および−４４ならびにそれらの用途
WO2009117656A2 (en) 2008-03-21 2009-09-24 Vectorlogics,Inc. Capsid-incorporated antigen for novel adenovirus vaccine
US20110086063A1 (en) 2008-06-04 2011-04-14 Cornell University Vaccines for prevention and treatment of addiction
ES2491522T3 (es) 2008-06-19 2014-09-08 Millennium Pharmaceuticals, Inc. Derivados de tiofeno o tiazol y su uso como inhibidores de PI3K
KR101034811B1 (ko) 2008-08-25 2011-05-16 단국대학교 산학협력단 조직 특이적 프로모터와 암 특이 유전자를 타겟팅하는트랜스-스플라이싱 라이보자임을 포함하는 재조합아데노바이러스 및 이의 용도
WO2010025310A2 (en) 2008-08-27 2010-03-04 Westend Asset Clearinghouse Company, Llc Methods and devices for high fidelity polynucleotide synthesis
KR20110081222A (ko) 2008-09-26 2011-07-13 어번 유니버시티 비복제성 벡터화된 백신의 점막 투여에 의한 조류의 면역화
WO2010051367A1 (en) 2008-10-31 2010-05-06 The Trustees Of The University Of Pennsylvania Simian adenoviruses sadv-43, -45,-48,-49, and -50 and uses thereof
AU2009332883B2 (en) 2008-12-22 2015-05-21 Oncos Therapeutics Oy Oncolytic adenoviral vectors and methods and uses related thereto
US9345787B2 (en) 2008-12-22 2016-05-24 Targovax Oy Adenoviral vectors and methods and uses related thereto
PL2391638T3 (pl) 2009-02-02 2018-11-30 Glaxosmithkline Biologicals Sa Sekwencje nukleotydowe i aminokwasowe małpiego adenowirusa, zawierające je wektory i ich zastosowania
HUE026386T2 (en) 2009-03-02 2016-06-28 Univ California Tumor-selective adenovirus e1a and e1b mutants
ES2385251B1 (es) 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge Adenovirus oncolíticos para el tratamiento del cáncer.
CA2762203A1 (en) 2009-05-29 2010-12-02 Soumitra Roy Simian adenovirus 41 and uses thereof
JP5903045B2 (ja) 2009-07-31 2016-04-13 パックスバックス， インコーポレイテッド アデノウイルスに基づくベクター
US9555089B2 (en) 2009-08-18 2017-01-31 The Rockefeller University Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes
WO2011022002A1 (en) 2009-08-18 2011-02-24 The Rockefeller University Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes
KR101248912B1 (ko) 2009-12-31 2013-03-29 한양대학교 산학협력단 항혈관신생 활성을 가지는 재조합 아데노바이러스
US9163261B2 (en) 2010-02-22 2015-10-20 Koteswara Rao KOLLIPARA Adeno-associated virus 2/8—micro RNA-101 therapy for liver cancer
CN102191245B (zh) 2010-03-15 2013-11-13 浙江东方基因生物制品有限公司 应用肿瘤特异性启动子表达报告基因来检测循环血中肿瘤细胞的方法和试剂
EP2547362B1 (en) 2010-03-17 2021-08-25 Cornell University Disrupted adenovirus-based vaccine against drugs of abuse
EP2558481B1 (en) 2010-04-14 2017-12-20 Mogam Biotechnology Research Institute Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same
WO2011133040A2 (en) 2010-04-23 2011-10-27 Orca Therapeutics B.V. Replication-competent adenoviruses
US9018182B2 (en) 2010-04-26 2015-04-28 Green Cross Corporation Tumor specific promoter and oncolytic virus vector comprising the same
KR101915699B1 (ko) 2010-06-10 2018-11-06 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 데스모글레인 2(디에스쥐2)와 아데노바이러스의 상호작용을 위한 방법 및 시스템
US20140017668A1 (en) 2010-06-30 2014-01-16 The Johns Hopkins University COMPOSITIONS AND METHODS FOR DETECTING AND QUANTIFYING CIRCULATING TUMOR CELLS (CTCs)
BR112013003579A2 (pt) 2010-08-16 2016-06-07 Salk Inst For Biological Studi adenovírus, células, e, métodos para tratar câncer
WO2012022496A2 (en) 2010-08-19 2012-02-23 Per Sonne Holm Method for killing tumor stem cells
US20130323205A1 (en) 2010-09-24 2013-12-05 Oncos Therapeutics Oy Oncolytic adenoviral vectors and methods and uses related thereto
US20130243731A1 (en) 2010-09-24 2013-09-19 Oncos Therapeutics Oy Oncolytic adenoviral vectors coding for monoclonal anti-ctla-4 antibodies
AU2011332025B2 (en) 2010-11-23 2015-06-25 The Trustees Of The University Of Pennsylvania Subfamily E simian adenoviruses A1321, A1325, A1295, A1309 and A1322 and uses thereof
WO2012083297A2 (en) 2010-12-17 2012-06-21 Genvec, Inc. Adenoviral vectors with modified hexon regions
WO2012088041A1 (en) 2010-12-20 2012-06-28 Genvec, Inc. Adenoviral vector-based dengue fever vaccine
CN102174479B (zh) 2011-03-02 2013-04-03 北京锤特生物科技有限公司 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用
JP5975352B2 (ja) 2011-03-25 2016-08-23 国立大学法人 鹿児島大学 癌幹細胞を標的とするウイルスベクター
WO2012156933A1 (en) 2011-05-16 2012-11-22 Institut Gustave Roussy Combination of oncolytic adenoviruses with histone deacetylase inhibitors
WO2012162342A2 (en) 2011-05-23 2012-11-29 The Wistar Institute Of Anatomy And Biology Influenza vaccines containing modified adenovirus vectors
GB201108879D0 (en) 2011-05-25 2011-07-06 Isis Innovation Vector
CN102260712B (zh) 2011-05-31 2013-10-02 北京锤特生物科技有限公司 溶肿瘤能力增强的B型人腺病毒Ad11突变体的构建和应用
AU2012298013B2 (en) 2011-08-23 2015-09-24 National Institute Of Biomedical Innovation Conditionally replicating adenovirus
WO2013036791A2 (en) 2011-09-09 2013-03-14 Beth Israel Deaconess Medical Center, Inc. Modified adenoviral vectors and methods of treatment using same
JP6757120B2 (ja) 2011-10-05 2020-09-16 ジェンヴェック エルエルシー アーフェンアデノウイルス（ゴリラ）又はアデノウイルスベクター、及び使用方法
WO2013052915A2 (en) 2011-10-05 2013-04-11 Genelux Corporation Method for detecting replication or colonization of a biological therapeutic
FI123955B (en) 2011-11-25 2014-01-15 Oncos Therapeutics Ltd Oncolytic adenovirus
EP2798069B1 (en) 2011-12-15 2017-03-29 Washington University Porcine knob xenotype chimeric adenoviral vector for dendritic cell infection
WO2013116778A2 (en) 2012-02-02 2013-08-08 Board Of Regents Immunogenic adenovirus
SI2825640T1 (sl) 2012-03-12 2016-08-31 Crucell Holland B.V. Šarže rekombinantnega adenovirusa s spremenjenimi konci
CN104411826A (zh) 2012-03-13 2015-03-11 萨克生物研究学院 使用腺病毒和化学二聚体的选择性细胞寻靶
EP2825889A4 (en) 2012-03-14 2015-10-28 Salk Inst For Biological Studi ADENOVIRAL TUMOR DIAGNOSIS
US9017672B2 (en) 2012-05-11 2015-04-28 Immunicum Aktiebolag Hexon Tat-PTD modified adenovirus and uses thereof
SG11201407343XA (en) 2012-05-18 2014-12-30 Univ Pennsylvania Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof
EP2855685B1 (en) 2012-05-24 2017-03-08 Janssen Vaccines & Prevention B.V. Adenoviral vectors for transduction of vascular tissue
WO2013181128A1 (en) 2012-05-29 2013-12-05 Genvec, Inc. Modified serotype 28 adenoviral vectors
AU2013203696A1 (en) 2012-06-25 2014-01-16 University Of Canberra Recombinant Viral Vectors and Uses Therefor
EP2900818B1 (en) 2012-09-25 2017-06-07 University of Washington through its Center for Commercialization Desmoglein 2 (dsg2) binding proteins and uses therefor
KR101429696B1 (ko) 2012-11-21 2014-08-13 국립암센터 안전성 및 항암활성이 증가된 재조합 아데노바이러스 및 이의 용도
BR112015021297A2 (pt) 2013-02-28 2017-10-10 Psioxus Therapeutics Ltd um processo para a produção de adenovírus.
WO2014160475A1 (en) 2013-03-13 2014-10-02 Aboody Karen S Tropic cell based virotherapy for the treatment of cancer
SG11201507393TA (en) 2013-03-14 2015-10-29 Salk Inst For Biological Studi Oncolytic adenovirus compositions
DK2986311T3 (en) 2013-04-18 2019-02-25 Tilt Biotherapeutics Oy IMPROVED ADOPTIVE CELL THERAPY
EP3010519B1 (en) 2013-06-18 2021-04-07 Dnatrix Inc. Oncolytic adenovirus for use in a treatment of brain cancer
KR20210129274A (ko) 2013-09-24 2021-10-27 유니버시티 오브 워싱턴 데스모글레인 2 (dsg2) 결합 단백질 및 그의 용도
CN106029889A (zh) 2013-11-22 2016-10-12 德那翠丝有限公司 表达免疫细胞刺激受体激动剂的腺病毒
GB201415579D0 (en) 2014-09-03 2014-10-15 Psioxus Therapeutics Ltd A process
GB201406608D0 (en) 2014-04-12 2014-05-28 Psioxus Therapeutics Ltd Virus
EP2940128A1 (en) 2014-04-30 2015-11-04 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Adenovirus comprising an albumin-binding moiety
US10799568B2 (en) 2014-05-19 2020-10-13 Valo Therapeutics Oy Modified adenoviruses for cancer vaccines development
JP6566214B2 (ja) 2014-05-28 2019-08-28 国立大学法人 岡山大学 Ｒｅｉｃ遺伝子を発現する制限増殖型アデノウイルス
KR102608590B1 (ko) 2014-09-24 2023-12-01 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양 살상 바이러스 및 이의 사용방법
WO2016106178A1 (en) 2014-12-24 2016-06-30 The Uab Research Foundation, Inc. Multitargeting onocolytic adenovirus, methods of use, and methods of making
WO2016118433A1 (en) 2015-01-20 2016-07-28 Shayakhmetov Dmitry M Detargeted adenovirus variants and related methods
WO2016141073A1 (en) 2015-03-02 2016-09-09 Washington University Induction of pacemaker-like cells from cardiomyocytes
AU2016232009B2 (en) 2015-03-17 2021-07-15 Tilt Biotherapeutics Oy Oncolytic adenoviruses coding for bi-specific antibodies and methods and uses related thereto
EP3072900A1 (en) 2015-03-27 2016-09-28 Medizinische Hochschule Hannover Anti-tumour medicament based on adenovirus
GB201505860D0 (en) 2015-04-07 2015-05-20 Agalimmune Ltd Therapeutic compositions and methods of use for treating cancer
GB201513176D0 (en) 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
EP3329934B1 (en) 2015-09-01 2021-03-24 Genemedicine Co., Ltd. Antitumor immunity enhancing composition containing adenovirus simultaneously expressing il-12 and shvegf
EP3359175B1 (en) 2015-10-05 2020-09-16 Salk Institute for Biological Studies Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration
ES2994611T3 (en) 2015-10-19 2025-01-27 Cg Oncology Inc Methods of treating solid or lymphatic tumors by combination therapy
US11246896B2 (en) 2015-10-28 2022-02-15 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Tumor-specific adenovirus vectors and therapeutic uses
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
WO2017147269A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
WO2017156349A1 (en) 2016-03-10 2017-09-14 Cold Genesys, Inc. Methods of treating solid or lymphatic tumors by combination therapy
US20170314044A1 (en) 2016-05-02 2017-11-02 Regents Of The University Of Minnesota Adenovirus constructs and methods
US20190201551A1 (en) 2016-05-23 2019-07-04 Washington University Pulmonary targeted cas9/crispr for in vivo editing of disease genes
CN109789177A (zh) 2016-05-27 2019-05-21 德那翠丝有限公司 腺病毒和免疫调节剂组合治疗
GB2549809C (en) 2016-06-23 2022-11-30 Univ Oxford Innovation Ltd Vector
WO2018064523A1 (en) 2016-09-30 2018-04-05 Genvec, Inc. Adenovectors for delivery of therapeutic genetic material into t cells
FI20165814A7 (fi) 2016-10-27 2018-04-28 Tilt Biotherapeutics Oy Interleukiini 8 (il-8) prognostisena ja ennustavana biomarkkerina ja koostumukset ja vektorit käytettäväksi onkolyyttisessa immunoterapiassa
US20190275092A1 (en) 2016-11-01 2019-09-12 Dnatrix, Inc. Combination therapy for treatment of brain cancers
WO2018083259A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
WO2018083257A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
WO2018083258A1 (en) 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding at least three transgenes
US20190350992A1 (en) 2016-11-17 2019-11-21 Vcn Biosciences Sl Use of viral vectors in the treatment of retinoblastoma
ES2959811T3 (es) 2016-12-09 2024-02-28 Glaxosmithkline Biologicals Sa Construcciones de adenovirus de chimpancé con antígenos de Lyssavirus
GB201620968D0 (en) 2016-12-09 2017-01-25 Glaxosmithkline Biologicals Sa Adenovirus polynucleotides and polypeptides
EP3532082A4 (en) 2016-12-12 2020-08-26 Salk Institute for Biological Studies SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES
US10232053B2 (en) 2016-12-30 2019-03-19 Trieza Therapeutics, Inc. Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer
WO2018125970A1 (en) 2016-12-30 2018-07-05 Salk Institute For Biological Studies Synthetic adenoviruses targeting bone tissue and uses thereof
CA3052090A1 (en) 2017-01-30 2018-08-02 Epicentrx, Inc. Multiple transgene recombinant adenovirus
EP3573632B1 (en) 2017-01-30 2024-08-07 EpicentRx, Inc. Tumor selective tata-box and caat-box mutant oncolytic viruses
JP7229173B2 (ja) 2017-04-10 2023-02-27 エピセントアールエックス，インコーポレイテッド 組み換えウイルスを産生するための方法
EA201990822A1 (ru) 2017-04-12 2020-01-09 Эписентарикс, Инк. Иммуномодулирующие слитые белки
CA3060573A1 (en) 2017-04-21 2018-10-25 Baylor College Of Medicine Oncolytic virotherapy and immunotherapy
WO2018201017A1 (en) 2017-04-27 2018-11-01 Washington University Dendritic cell targeted adenovirus for vaccination
WO2018204677A1 (en) 2017-05-04 2018-11-08 Epicentrx, Inc. Oncolytic adenovirus formulation
US20200155625A1 (en) 2017-05-24 2020-05-21 Epicentrx, Inc. Anti-angiogenic adenovirus
CN111201035A (zh) 2017-06-19 2020-05-26 梅迪塞纳医疗股份有限公司 Il-2超激动剂、激动剂及其融合体的用途和方法
WO2019016756A1 (en) 2017-07-21 2019-01-24 Glaxosmithkline Biologicals Sa ANTIGEN CONSTRUCTS OF CHIKUNGUNYA VIRUSES
EP3460052B1 (en) 2017-09-20 2019-10-30 Immunicum AB Improved allogeneic dendritic cells for use in cancer treatment
US12123027B2 (en) 2017-10-12 2024-10-22 Ascend Advanced Therapies Limited Life-cycle-defective adenovirus helper viruses, their production and use for producing rAAV
CN111372943B (zh) 2017-10-31 2023-12-05 扬森疫苗与预防公司 腺病毒及其用途
WO2019086461A1 (en) 2017-10-31 2019-05-09 Janssen Vaccines & Prevention B.V. Adenovirus vectors and uses thereof
WO2019086450A1 (en) 2017-10-31 2019-05-09 Janssen Vaccines & Prevention B.V. Adenovirus and uses thereof
WO2019086466A1 (en) 2017-10-31 2019-05-09 Janssen Vaccines & Prevention B.V. Adenovirus and uses thereof
GB201802539D0 (en) 2018-02-16 2018-04-04 Univ College Cardiff Consultants Ltd Modified adenoviruses
GB201804473D0 (en) 2018-03-21 2018-05-02 Valo Therapeutics Oy Modified oncolytic adenoviruses
GB201804468D0 (en) 2018-03-21 2018-05-02 Valo Therapeutics Oy PeptiCRAd Cancer Therapy
EP3773649A4 (en) 2018-03-28 2022-02-23 EpicentRx, Inc. PERSONALIZED CANCER VACCINE
CN112292449A (zh) 2018-04-09 2021-01-29 萨克生物研究学院 具有增强的复制特性的溶瘤腺病毒组合物
WO2019202118A1 (en) 2018-04-20 2019-10-24 Baylor College Of Medicine Oncolytic virotherapy and immunotherapy
EP3807298A1 (en) 2018-06-12 2021-04-21 GlaxoSmithKline Biologicals S.A. Adenovirus polynucleotides and polypeptides
WO2020014539A1 (en) 2018-07-11 2020-01-16 Epicentrx, Inc. Methods and compositions for targeting cancer cells for treatment
WO2020046130A1 (en) 2018-08-31 2020-03-05 Orca Therapeutics B.V. Recombinant replication competent viruses comprising a coding region for glycogen synthase kinase-3 (gsk3) and methods of killing aberrant cells
JP7384457B2 (ja) 2018-10-09 2023-11-21 ナイキジェン，リミテッド ウイルスベクターを調製するための組成物および方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012024351A2 (en) * 2010-08-16 2012-02-23 Salk Institute For Biological Studies Adenoviral assembly method

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Cancer Cell. 2002, vol. 1, no. 4, pp. 325-337. *
Cancer Res. 2008, vol. 68, pp. 5533-5539.* *
Molecular Therapy. 2012, vol. 20, no. 12, pp. 2222-2233. *

Also Published As

Publication number Publication date
JP2021007392A (ja) 2021-01-28
KR102814615B1 (ko) 2025-05-28
AU2015320665A1 (en) 2017-04-06
EP3198009A4 (en) 2018-09-05
EP4043021A2 (en) 2022-08-17
JP7416423B2 (ja) 2024-01-17
ES2899913T3 (es) 2022-03-15
KR20230165385A (ko) 2023-12-05
AU2015320665B2 (en) 2022-06-16
AU2025203440A1 (en) 2025-06-05
CA2961748A1 (en) 2016-03-31
EP4043021A3 (en) 2022-11-23
EP3198009B1 (en) 2021-09-08
EP3198009A1 (en) 2017-08-02
WO2016049201A1 (en) 2016-03-31
US20170202893A1 (en) 2017-07-20
CN108064275A (zh) 2018-05-22
DK3198009T3 (da) 2021-11-22
JP6764859B2 (ja) 2020-10-07
AU2022203504A1 (en) 2022-06-09
KR20250081944A (ko) 2025-06-05
KR102608590B1 (ko) 2023-12-01
PL3198009T3 (pl) 2022-01-24
AU2022203504B2 (en) 2025-02-20
JP2024038030A (ja) 2024-03-19
JP2017534263A (ja) 2017-11-24
US12514887B2 (en) 2026-01-06

Similar Documents

Publication Publication Date Title
AU2022203504B2 (en) Oncolytic tumor viruses and methods of use
KR102471633B1 (ko) 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현
AU2011332025B2 (en) Subfamily E simian adenoviruses A1321, A1325, A1295, A1309 and A1322 and uses thereof
AU2020281047B2 (en) High throughput assay for measuring adenovirus replication kinetics
KR101761425B1 (ko) 시미안 아데노바이러스 핵산- 및 아미노산-서열, 이를 포함하는 벡터 및 이의 용도
AU2019251356B2 (en) Oncolytic adenovirus compositions with enhanced replication properties
KR101614364B1 (ko) 유인원 ｅ 아데노바이러스 ｓａｄｖ-39, -25.2, -26, -30, -37, 및 -38
KR101721725B1 (ko) 아데노바이러스 조립 방법
HK1252010A1 (zh) 猴腺病毒(大猩猩)或腺病毒载体及其使用方法
KR20100109914A (ko) 유인원 아과 ｂ 아데노바이러스 ｓａｄｖ-28,27,-29,-32,-33, 및 -35 및 그것의 사용
CN107574154A (zh) 猴(大猩猩)腺病毒或腺病毒载体及其使用方法
CN112011570B (zh) 特异杀伤肿瘤细胞的溶瘤病毒系统及其应用
KR20230008069A (ko) 아데노바이러스 발현 벡터, 및 제조를 위한 방법 및 세포주
CN116323955A (zh) 通过crispr/cas介导的体内末端解析拯救重组腺病毒
CN114262692A (zh) 一种携带tmvp1和hsv-tk的溶瘤腺病毒重组体，其构建方法及应用
CN114231504A (zh) 一种携带tmtp1和hsv-tk的溶瘤腺病毒重组体、其构建方法及应用
RU2829510C2 (ru) Онколитические аденовирусные композиции с улучшенными репликационными свойствами
KR102808930B1 (ko) 복제가능 아데노바이러스를 포함하지 않는 신규 아데노바이러스 벡터 및 이의 용도
RU2821989C1 (ru) Новый аденовирусный вектор, не включающий компетентный по репликации аденовирус, и его применение
NL2023464B1 (en) Oncolytic Non-human adenoviruses and uses thereof

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20170424

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
AMND Amendment
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20200922

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20211227

Patent event code: PE09021S01D

AMND Amendment
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20220919

Patent event code: PE09021S01D

AMND Amendment
E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20230407

AMND Amendment
PX0701 Decision of registration after re-examination

Patent event date: 20230825

Comment text: Decision to Grant Registration

Patent event code: PX07013S01D

Patent event date: 20230628

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20221216

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20220526

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20200922

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

X701 Decision to grant (after re-examination)
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20231127

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20231128

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20231128

End annual number: 3

Start annual number: 1

PG1601 Publication of registration