KR910019953A - 2,2-디메틸-5(2,5-디메텔페녹시)-펜탄산의 제조방법, 그 화합물 제조의 중간 물질 및 그 중간 물질의 제조 방법 - Google Patents

2,2-디메틸-5(2,5-디메텔페녹시)-펜탄산의 제조방법, 그 화합물 제조의 중간 물질 및 그 중간 물질의 제조 방법 Download PDF

Info

Publication number: KR910019953A
Authority: KR; South Korea
Prior art keywords: dimethyl; general formula; group; formula; optionally substituted
Prior art date: 1990-05-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

KR1019910007588A

Other languages

English (en)

Korean (ko)

Inventor

즈보빅스 졸탄

페헤르 가볼

톨디 라조스

코박스 가볼

시마이 안탈

코박스 네 보조 에바

모라브치크 임레

스제델케니 페렌

크라스나이 괴르기

베레츠케이 네 도나쓰 괴르기이

나기 칼만

Original Assignee

크사바키스, 아티라 만디

에기스 괴기스제르기야르

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-11

Filing date

1991-05-10

Publication date

1991-12-19

1991-05-10 Application filed by 크사바키스, 아티라 만디, 에기스 괴기스제르기야르 filed Critical 크사바키스, 아티라 만디

1991-12-19 Publication of KR910019953A publication Critical patent/KR910019953A/ko

Status Withdrawn legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title claims 8
238000000034 method Methods 0.000 title claims 4
-1 2,5-dimethylphenoxy Chemical group 0.000 claims 8
125000002947 alkylene group Chemical group 0.000 claims 8
150000002148 esters Chemical class 0.000 claims 8
125000000217 alkyl group Chemical group 0.000 claims 5
239000003054 catalyst Substances 0.000 claims 5
125000005842 heteroatom Chemical group 0.000 claims 5
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 5
239000001301 oxygen Substances 0.000 claims 5
229910052760 oxygen Inorganic materials 0.000 claims 5
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 4
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 4
238000004519 manufacturing process Methods 0.000 claims 4
229910052757 nitrogen Inorganic materials 0.000 claims 4
125000004433 nitrogen atom Chemical group N* 0.000 claims 4
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
239000003513 alkali Substances 0.000 claims 3
229910052736 halogen Inorganic materials 0.000 claims 3
150000002367 halogens Chemical group 0.000 claims 3
230000004048 modification Effects 0.000 claims 3
238000012986 modification Methods 0.000 claims 3
239000003960 organic solvent Substances 0.000 claims 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
150000005846 sugar alcohols Polymers 0.000 claims 3
NKTOLZVEWDHZMU-UHFFFAOYSA-N 2,5-xylenol Chemical compound CC1=CC=C(C)C(O)=C1 NKTOLZVEWDHZMU-UHFFFAOYSA-N 0.000 claims 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 claims 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
150000001447 alkali salts Chemical class 0.000 claims 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
229910052794 bromium Inorganic materials 0.000 claims 2
239000000460 chlorine Substances 0.000 claims 2
229910052801 chlorine Inorganic materials 0.000 claims 2
125000005843 halogen group Chemical group 0.000 claims 2
KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 2
150000007530 organic bases Chemical class 0.000 claims 2
238000007348 radical reaction Methods 0.000 claims 2
239000002904 solvent Substances 0.000 claims 2
BGUAPYRHJPWVEM-UHFFFAOYSA-N 2,2-dimethyl-4-pentenoic acid Chemical compound OC(=O)C(C)(C)CC=C BGUAPYRHJPWVEM-UHFFFAOYSA-N 0.000 claims 1
QWBBPBRQALCEIZ-UHFFFAOYSA-N 2,3-dimethylphenol Chemical compound CC1=CC=CC(O)=C1C QWBBPBRQALCEIZ-UHFFFAOYSA-N 0.000 claims 1
QSUIFZZKDFISFF-UHFFFAOYSA-N 2-[2-(5-chloro-2,2-dimethylpentanoyl)oxyethoxy]ethyl 5-chloro-2,2-dimethylpentanoate Chemical compound ClCCCC(C)(C)C(=O)OCCOCCOC(=O)C(C)(C)CCCCl QSUIFZZKDFISFF-UHFFFAOYSA-N 0.000 claims 1
XDGQCAGKOIZLHF-UHFFFAOYSA-N 3-(5-chloro-2,2-dimethylpentanoyl)oxypropyl 5-chloro-2,2-dimethylpentanoate Chemical compound ClCCCC(C)(C)C(=O)OCCCOC(=O)C(C)(C)CCCCl XDGQCAGKOIZLHF-UHFFFAOYSA-N 0.000 claims 1
ADEVRDAGHBXDKK-UHFFFAOYSA-N 3-(5-iodo-2,2-dimethylpentanoyl)oxypropyl 5-iodo-2,2-dimethylpentanoate Chemical compound ICCCC(C)(C)C(=O)OCCCOC(=O)C(C)(C)CCCI ADEVRDAGHBXDKK-UHFFFAOYSA-N 0.000 claims 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
239000002253 acid Substances 0.000 claims 1
125000001931 aliphatic group Chemical group 0.000 claims 1
125000002355 alkine group Chemical group 0.000 claims 1
150000004945 aromatic hydrocarbons Chemical class 0.000 claims 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
239000002585 base Substances 0.000 claims 1
150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
125000000623 heterocyclic group Chemical group 0.000 claims 1
239000001257 hydrogen Substances 0.000 claims 1
229910052739 hydrogen Inorganic materials 0.000 claims 1
239000012433 hydrogen halide Substances 0.000 claims 1
229910000039 hydrogen halide Inorganic materials 0.000 claims 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
230000003301 hydrolyzing effect Effects 0.000 claims 1
150000004694 iodide salts Chemical class 0.000 claims 1
239000000203 mixture Substances 0.000 claims 1
239000012454 non-polar solvent Substances 0.000 claims 1
239000003880 polar aprotic solvent Substances 0.000 claims 1
LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 claims 1
230000001737 promoting effect Effects 0.000 claims 1
239000011541 reaction mixture Substances 0.000 claims 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
- C07C59/13—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

KR1019910007588A 1990-05-11 1991-05-10 2,2-디메틸-5(2,5-디메텔페녹시)-펜탄산의 제조방법, 그 화합물 제조의 중간 물질 및 그 중간 물질의 제조 방법 Withdrawn KR910019953A (ko)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU2997/90		1990-05-11
HU902997A HU205891B (en)	1990-05-11	1990-05-11	Process for producing 2,2-dimethyl-5-/2,5-dimethyl-phenoxy/-pentanoic acid

Publications (1)

Publication Number	Publication Date
KR910019953A true KR910019953A (ko)	1991-12-19

Family

ID=10962060

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1019910007588A Withdrawn KR910019953A (ko)	1990-05-11	1991-05-10	2,2-디메틸-5(2,5-디메텔페녹시)-펜탄산의 제조방법, 그 화합물 제조의 중간 물질 및 그 중간 물질의 제조 방법

Country Status (22)

Country	Link
US (1)	US5155260A (cs)
JP (1)	JP2511335B2 (cs)
KR (1)	KR910019953A (cs)
CN (1)	CN1032134C (cs)
AT (1)	AT400716B (cs)
BG (1)	BG60580B1 (cs)
CA (1)	CA2042304A1 (cs)
CH (1)	CH683340A5 (cs)
CZ (1)	CZ282906B6 (cs)
DE (1)	DE4115540A1 (cs)
DK (1)	DK88091A (cs)
ES (1)	ES2036438B1 (cs)
FI (1)	FI912303A7 (cs)
FR (1)	FR2661908B1 (cs)
GB (1)	GB2244271B (cs)
GR (1)	GR1002053B (cs)
HU (2)	HU205891B (cs)
IT (1)	IT1253707B (cs)
NL (1)	NL9100811A (cs)
PL (1)	PL290204A1 (cs)
RU (1)	RU2056403C1 (cs)
YU (1)	YU48481B (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002543194A (ja) *	1999-04-28	2002-12-17	ドクター・レディーズ・ラボラトリーズ・リミテッド	置換二環系ヘテロ環化合物、その製造方法、並びに抗肥満症及び抗高コレステロール血症剤としてのこれらの使用
JP5549230B2 (ja)	2010-01-13	2014-07-16	株式会社リコー	測距装置、測距用モジュール及びこれを用いた撮像装置
JP5809390B2 (ja)	2010-02-03	2015-11-10	株式会社リコー	測距・測光装置及び撮像装置
JP5523993B2 (ja)	2010-08-31	2014-06-18	富士フイルム株式会社	酸ハロゲン化物の製造方法、及び酸ハロゲン化物
ES3065854T3 (en)	2011-12-07	2026-05-08	Alnylam Pharmaceuticals Inc	Biodegradable lipids for the delivery of active agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3674836A (en) *	1968-05-21	1972-07-04	Parke Davis & Co	2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
US3759986A (en) *	1970-03-30	1973-09-18	Parke Davis & Co	Esters of 2,2-dimethyl-5-(aryloxy)-1-pentanols
US3847994A (en) *	1970-03-30	1974-11-12	Parke Davis & Co	2,2-dimethyl-5-(aryloxy)-valeraldehydes
GB2025942A (en) *	1978-05-31	1980-01-30	Sori Soc Rech Ind	Phenoxyalkylcarboxylic acids
DK305884A (da) *	1983-06-24	1984-12-25	Yamanouchi Pharma Co Ltd	Phenoxyderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
ES534473A0 (es) *	1984-07-20	1985-06-01	Valles Rodoreda Enrique	Procedimiento para la obtencion del acido 2, 2-dimetil-5(2, 5-xililoxi) valerico
ES8605217A1 (es) *	1985-12-02	1986-03-16	Servicios Y Suministros Farmac	Procedimiento de obtencion del acido 2,2-dimetil-5-(2,5-di- metil-fenoxi)valerico
ES8605216A1 (es) *	1985-12-02	1986-03-16	Servicios Y Suministros Farmac	Procedimiento para la obtencion del acido 2,2-dimetil-5-(2, 5-dimetil-fenoxi)valerico y sus sales farmaceuticamente aceptables
US4665226A (en) *	1985-12-09	1987-05-12	Warner-Lambert Company	Process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid

1990
- 1990-05-11 HU HU902997A patent/HU205891B/hu not_active IP Right Cessation
- 1990-05-11 HU HU9200347A patent/HU210180B/hu unknown
1991
- 1991-05-08 CZ CS911359A patent/CZ282906B6/cs not_active IP Right Cessation
- 1991-05-08 CH CH1387/91A patent/CH683340A5/de not_active IP Right Cessation
- 1991-05-10 KR KR1019910007588A patent/KR910019953A/ko not_active Withdrawn
- 1991-05-10 IT ITMI911290A patent/IT1253707B/it active IP Right Grant
- 1991-05-10 FR FR9105682A patent/FR2661908B1/fr not_active Expired - Fee Related
- 1991-05-10 FI FI912303A patent/FI912303A7/fi not_active Application Discontinuation
- 1991-05-10 RU SU914895518A patent/RU2056403C1/ru active
- 1991-05-10 CN CN91102985A patent/CN1032134C/zh not_active Expired - Fee Related
- 1991-05-10 NL NL9100811A patent/NL9100811A/nl not_active Application Discontinuation
- 1991-05-10 PL PL29020491A patent/PL290204A1/xx unknown
- 1991-05-10 AT AT0096791A patent/AT400716B/de not_active IP Right Cessation
- 1991-05-10 GR GR910100202A patent/GR1002053B/el unknown
- 1991-05-10 JP JP3135444A patent/JP2511335B2/ja not_active Expired - Lifetime
- 1991-05-10 GB GB9110157A patent/GB2244271B/en not_active Expired - Fee Related
- 1991-05-10 DK DK088091A patent/DK88091A/da not_active Application Discontinuation
- 1991-05-10 ES ES09101150A patent/ES2036438B1/es not_active Expired - Fee Related
- 1991-05-10 YU YU81391A patent/YU48481B/sh unknown
- 1991-05-10 BG BG94402A patent/BG60580B1/bg unknown
- 1991-05-10 US US07/698,081 patent/US5155260A/en not_active Expired - Fee Related
- 1991-05-10 CA CA002042304A patent/CA2042304A1/en not_active Abandoned
- 1991-05-13 DE DE4115540A patent/DE4115540A1/de not_active Withdrawn

Also Published As

Publication number	Publication date
DE4115540A1 (de)	1991-11-14
HU902997D0 (en)	1990-09-28
ES2036438B1 (es)	1994-05-16
GR910100202A (el)	1992-07-30
CS9101359A2 (en)	1991-11-12
AT400716B (de)	1996-03-25
ATA96791A (de)	1995-07-15
US5155260A (en)	1992-10-13
ES2036438A1 (es)	1993-05-16
FI912303A0 (fi)	1991-05-10
FR2661908A1 (fr)	1991-11-15
JPH04226936A (ja)	1992-08-17
HU205891B (en)	1992-07-28
DK88091A (da)	1991-11-12
HU210180B (en)	1995-02-28
NL9100811A (nl)	1991-12-02
FR2661908B1 (fr)	1995-10-27
CN1056487A (zh)	1991-11-27
FI912303A7 (fi)	1991-11-12
JP2511335B2 (ja)	1996-06-26
PL290204A1 (en)	1992-09-21
GR1002053B (en)	1995-11-20
CZ282906B6 (cs)	1997-11-12
CA2042304A1 (en)	1991-11-12
HUT57176A (en)	1991-11-28
CH683340A5 (de)	1994-02-28
IT1253707B (it)	1995-08-23
CN1032134C (zh)	1996-06-26
GB2244271B (en)	1994-05-11
YU81391A (sh)	1993-11-16
DK88091D0 (da)	1991-05-10
RU2056403C1 (ru)	1996-03-20
YU48481B (sh)	1998-09-18
GB9110157D0 (en)	1991-07-03
GB2244271A (en)	1991-11-27
ITMI911290A0 (it)	1991-05-10
BG60580B1 (bg)	1995-09-29
BG94402A (bg)	1993-12-24
ITMI911290A1 (it)	1992-11-10

Legal Events

Date	Code	Title	Description
1991-05-10	PA0109	Patent application	Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19910510
1991-12-19	PG1501	Laying open of application
1996-05-10	PC1203	Withdrawal of no request for examination
1996-05-10	WITN	Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid

Publication	Publication Date	Title
KR880000398A (ko)	1988-03-25	(r)-2-[4-(5-클로로-3-플루오로피리딘-2-일옥시)-페녹시]-프로피온산 프로피닐 에스테르의 제조방법
KR940009152A (ko)	1994-05-20	카르바졸론 유도체 및 이의 제조방법
ATE6771T1 (de)	1984-04-15	Verfahren zum substituieren aromatischer organischer derivate.
JPS6145611B2 (cs)	1986-10-08
KR930007879A (ko)	1993-05-20	히드록시페닐카르복실레이트의 제조방법
KR890701564A (ko)	1989-12-21	퀴놀린 카복실산 유도체를 제조하는 방법
KR900006684B1 (ko)	1990-09-17	아릴옥시페녹시 프로파노산 에스테르의 제조방법
GB705950A (en)	1954-03-24	Improvements in or relating to acetals containing cyanoacetyl groups and photographic processes using the same
KR840007556A (ko)	1984-12-08	방향족 히드록시카르복시산 벤질 에스테르의 제조방법
EP0007652B1 (en)	1982-02-10	Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
KR860004004A (ko)	1986-06-16	4-아실옥시-3-옥소- 부티르산 에스테르의 제조방법
KR890014437A (ko)	1989-10-23	2-(4-히드록시페녹시)알칸산의 합성 방법
KR960702828A (ko)	1996-05-23	(R) - 및 (S)-2-(4-알카노일페녹시) - 또는 (R) - 및 (S)-2-(4-아로일페녹시) 프로피온산 에스테르의 혼합물의 제조 방법 (The Preparation of Mixtures of (R) - and (S)-2-(4-Alkanoylphenoxy) - or (R) - and (S)-2-(4-Aroylphenoxy) propionic Esters
US4681941A (en)	1987-07-21	Method of preparing esters of aryloxyphenoxy propanoic acid
US5852208A (en)	1998-12-22	Method of producing compounds containing acyloxyalkoxy groups from alcohols
EP0127276A2 (en)	1984-12-05	Carbonylation process
EP0183797B1 (en)	1989-07-19	5-halo-4h-1,3-dioxin-4-one compounds, process for their preparation and their use in the preparation of alpha-halo-acetoacetic esters
FI58909B (fi)	1981-01-30	Foerfarande foer framstaellning av den terapeutiskt aktiva foereningen 1-isopropylamino-3-(4-(2-metoxietyl)-fenoxi)-2-propanol och dess syraadditionssalter
KR920012048A (ko)	1992-07-25	퀴녹살리닐옥시페녹시프로피온산의 광학적 활성 에스테르의 제조방법
BG60580B1 (bg)	1995-09-29	Метод за получаване на 2,2-диметил-5-(2,5-диметилфенокси)- пентанова киселина,междинни съединения за получаването й и метод за получаване на междинните съединения
JP2974181B2 (ja)	1999-11-08	シクロブタノールの新規な製造法
KR870000308A (ko)	1987-02-17	아릴 옥시벤젠 아세트산 유도체의 제조방법
KR880002619B1 (ko)	1988-12-07	메토프로롤의 제조방법
US4163111A (en)	1979-07-31	2-Cyclopentenone derivatives
US4582913A (en)	1986-04-15	5-halo-4H-1,3-dioxin-4-one compounds