KR920703045A - 에스테르와 아미드로 소양증을 치료하는 방법 - Google Patents

에스테르와 아미드로 소양증을 치료하는 방법

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Publication number
KR920703045A
KR920703045A KR1019920701937A KR920701937A KR920703045A KR 920703045 A KR920703045 A KR 920703045A KR 1019920701937 A KR1019920701937 A KR 1019920701937A KR 920701937 A KR920701937 A KR 920701937A KR 920703045 A KR920703045 A KR 920703045A
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Prior art keywords
acid
compound
dimethylamide
group
esters
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KR1019920701937A
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KR950014448B1 (ko
Inventor
리챠드 토른펠트 칼
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원본미기재
데르마토로직 리서치 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

내용 없음

Description

에스테르와 아미드로 소양증을 치료하는 방법
[도면의 간단한 설명]
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 소양증을 나타내는 질환상태를 겪고 있는 검체를 치료하는 방법에 있어서, 상기 방법 상기 검체에 탄소원자수가 5개 내지 19개인 모노카르복실산의 에스테르와 아미드로 이루어지는 군으로 부터 선택된 화합물이 약 0.5 내지 약 35중량% 함유된 치료적 유효량의 피부과학적 제제를 투여하는 것으로 이루어지는 치료방법.
  2. 심인성 또는 뇌쇠성 소양증을 겪고 있는 검체를 치료하는 방법에 있어서, 상기 방법 상기 검체에 탄소원자수가 5개 내지 19개인 모노카르복실산의 에스테르와 아미드로 이루어지는 군으로 부터 선택된 화합물이 약 0.5 내지 약 35중량% 함유된 치료적 유효량의 피부과학적 제제를 투여하는 것으로 이루어지는 치료방법.
  3. 제1항에 있어서, 상기 제형에 아민과 카민, 마취제, 케톤류, 알코올류, 항히스타민류, 코르티코스테로이드류, 반대자극제류, 타르 및 살리실산으로 이루어지는 군으로 부터 선택된 1종 이상의 성분이 더 포함되는 것을 특징으로 하는 치료방법.
  4. 제1항에 있어서. 상기 제형에 부타멘, 벤조카인, 디부카인, 디메티소퀸, 디클로닌, 리도카인, 테트라카인, 장뇌, 벤질알코올, 멘톨, 프라목신, 페놀, 폐놀화나트륨, 레조르씨놀, 타르, 캄포르화 메타크레졸, 디펜히드라인, 트리펠렌아민, 히드로코르티손, 히스타민, 니코틴산 메틸, 고추, 살리실산 메틸, 투르펜틴 오일, 알릴이소티오시아네이트, 암모니아 및 살리실산으로 부터 선택된 1종 이상의 요소가 더 포함되는 것을 특징으로` 하는 치료방법.
  5. 제1항에 있어서, 상기 피부과학적 제형이 약 1% 내지 약 11중량%의 상기 화합물로 이루어지는 것을 특징으로 하는 방법.
  6. 제1항에 있어서, 상기 모노카르복실산은 탄소원자 9 내지 18개 길이의 직쇄형 모노카르복실산인 것을 특징으로 하는 방법.
  7. 제1항 내지 제6항 중의 어느 한 항에 있어서, 상기 화합물이 글리세리드, 삭카라이드, 그리고 메탄올, 에탄올, 프로필렌 글리콜 및 폴리에틸렌 글리콜의 에스테르로 이루어지는 군으로부터 선택되는 에스테르인 것을 특징으로하는 방법.
  8. 제1항 내지 제6항 중의 어느 한 항에 있어서, 상기 화합물이 모노글리세리드, 트리글리세리드, 헥사글리세리드, 데카글리세리드 및 수크로오스 에스테르로 이루어지는 군으로 부터 선택되는 에스테르인 것을 특징으로 하는 방법.
  9. 제1항 내지 제6항 중의 어느 한 항에 있어서, 상기 화합물이 1-모노라우린, 2-모노라우린, 모노카프린, 모노미리스틴, 모노리놀레인, 카프릴산트리글리세롤, 펠라르곤산 트리글리세롤, 카프론산 헥사글리세롤, 카프릴산 헥사글리세롤, 펠라르곤산 헥사글리세롤, 카프론산 헥사글리세롤, 라우릴산 헥사글리세롤, 부티르산 데카글리세롤, 카프릴산 데카글리세롤, 펠라르곤산 데카글리세롤, 카프론산 데카글리세롤, 라우릴산 데카글리세롤, 미리스틴산 수크로오스, 팔미틴산 수크로오스, 엘라이딘산 수크로오스, 올레인산 수크로오스 및 리놀레 인산 수크로오스로 이루어진 군으로부터 선택되는 것을 특징으로 하는 방법.
  10. 제1항 내지 제6항 중의 어느 한 항에 있어서, 상기 화합물이 1-모노라우린인 것을 특징으로 하는 방법.
  11. 제1항 내지 제6항 중의 어느 한 항에 있어서, 상기 화합물이 카프라토일-N,N-디메틸아미드, 라우릴-N,N-디메틸아미드, 미리스토레일-N.N-디메틸아미드, 팔미롤레일-N, N-디메틸아미드, 리놀레일-N,N-디메틸아미드 및 옥타데카노일-N,N-디메틸아미드로 이루어지는 군으로 부터 선택된 아미드인 것을 특징으로 하는 방법.
  12. 제1항 내지 제6항 증의 어느 한 항에 있어서, 상기 화합물이 라우릴-N,N-디메틸아미드인 것을 특징으로 하는 방법.
  13. 제1항 내지 제6항 중의 어느 한 항에 있어서, 상기 피부과학적 제형에 각질층 관입증강제를 더 함유하는 것을 특징으로 하는 방법.
  14. ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019920701937A 1990-02-12 1991-02-11 소양증 치료를 위한 피부과용 약제 조성물 Expired - Fee Related KR950014448B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US478871 1990-02-12
US478.871 1990-02-12
US07/478,871 US5057500A (en) 1990-02-12 1990-02-12 Treatment of pruritis with esters and amides
PCT/US1991/000946 WO1991012010A1 (en) 1990-02-12 1991-02-11 Treatment of pruritis with esters and amides

Publications (2)

Publication Number Publication Date
KR920703045A true KR920703045A (ko) 1992-12-17
KR950014448B1 KR950014448B1 (ko) 1995-11-28

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Country Link
US (1) US5057500A (ko)
EP (1) EP0515517B1 (ko)
JP (1) JP2554419B2 (ko)
KR (1) KR950014448B1 (ko)
AT (1) ATE181238T1 (ko)
AU (1) AU644552B2 (ko)
CA (1) CA2074493C (ko)
DE (1) DE69131345T2 (ko)
DK (1) DK0515517T3 (ko)
ES (1) ES2135391T3 (ko)
GR (1) GR3030997T3 (ko)
WO (1) WO1991012010A1 (ko)

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EP0515517A1 (en) 1992-12-02
EP0515517B1 (en) 1999-06-16
DK0515517T3 (da) 1999-11-22
DE69131345T2 (de) 2000-02-24
WO1991012010A1 (en) 1991-08-22
CA2074493C (en) 1995-10-03
ATE181238T1 (de) 1999-07-15
DE69131345D1 (de) 1999-07-22
JP2554419B2 (ja) 1996-11-13
AU7325991A (en) 1991-09-03
CA2074493A1 (en) 1991-08-13
AU644552B2 (en) 1993-12-09
JPH05502677A (ja) 1993-05-13
ES2135391T3 (es) 1999-11-01
GR3030997T3 (en) 1999-12-31
US5057500A (en) 1991-10-15
EP0515517A4 (en) 1993-05-19
KR950014448B1 (ko) 1995-11-28

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