LT3244886T - Indolo dariniai kaip dengės virusinės replikacijos inhibitoriai - Google Patents

Indolo dariniai kaip dengės virusinės replikacijos inhibitoriai

Info

Publication number
LT3244886T
LT3244886T LTEPPCT/EP2016/050715T LT16050715T LT3244886T LT 3244886 T LT3244886 T LT 3244886T LT 16050715 T LT16050715 T LT 16050715T LT 3244886 T LT3244886 T LT 3244886T
Authority
LT
Lithuania
Prior art keywords
cover
viral replication
replication inhibitors
indol derivatives
indol
Prior art date
Application number
LTEPPCT/EP2016/050715T
Other languages
English (en)
Inventor
Bart Kesteleyn
Jean-François BONFANTI
Tim JONCKERS
Pierre Raboisson
Dorothée BARDIOT
Arnaud Marchand
Original Assignee
Janssen Pharmaceuticals, Inc.
Katholieke Universiteit Leuven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven filed Critical Janssen Pharmaceuticals, Inc.
Publication of LT3244886T publication Critical patent/LT3244886T/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
LTEPPCT/EP2016/050715T 2015-01-16 2016-01-15 Indolo dariniai kaip dengės virusinės replikacijos inhibitoriai LT3244886T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15151481 2015-01-16
PCT/EP2016/050715 WO2016113371A1 (en) 2015-01-16 2016-01-15 Indole derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number Publication Date
LT3244886T true LT3244886T (lt) 2021-12-27

Family

ID=52345130

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/EP2016/050715T LT3244886T (lt) 2015-01-16 2016-01-15 Indolo dariniai kaip dengės virusinės replikacijos inhibitoriai

Country Status (31)

Country Link
US (1) US10029984B2 (lt)
EP (1) EP3244886B1 (lt)
JP (1) JP6830438B2 (lt)
KR (1) KR102509848B1 (lt)
CN (1) CN107428685B (lt)
AR (1) AR103412A1 (lt)
AU (1) AU2016208015B2 (lt)
BR (1) BR112017015123B1 (lt)
CA (1) CA2972329C (lt)
CL (1) CL2017001822A1 (lt)
DK (1) DK3244886T3 (lt)
EA (1) EA032362B1 (lt)
ES (1) ES2904575T3 (lt)
HK (1) HK1247611A1 (lt)
HR (1) HRP20211782T1 (lt)
HU (1) HUE057299T2 (lt)
IL (1) IL253434B (lt)
JO (1) JOP20150335B1 (lt)
LT (1) LT3244886T (lt)
MA (1) MA41341A (lt)
MX (1) MX381538B (lt)
MY (1) MY187068A (lt)
NZ (1) NZ733313A (lt)
PH (1) PH12017501272B1 (lt)
SG (1) SG11201705760XA (lt)
SI (1) SI3244886T1 (lt)
TW (1) TWI700274B (lt)
UA (1) UA123002C2 (lt)
UY (1) UY36518A (lt)
WO (1) WO2016113371A1 (lt)
ZA (1) ZA201704783B (lt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
JOP20160086B1 (ar) * 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) * 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
SG11201808138YA (en) 2016-03-31 2018-10-30 Janssen Pharmaceuticals Inc Substituted indole derivatives as dengue viral replication inhibitors
MA44498A (fr) 2016-03-31 2019-02-06 Janssen Pharmaceuticals Inc Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
EP3436004B1 (en) 2016-04-01 2024-12-11 Janssen Pharmaceuticals, Inc. Substituted indole compound derivatives as dengue viral replication inhibitors
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) * 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CA3060583C (en) 2017-05-22 2024-06-04 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
SI3630724T1 (sl) 2017-05-22 2021-08-31 Janssen Pharmaceuticals, Inc. Substituirani derivati indolina kot zaviralci replikacije virusa denga

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2928645A1 (fr) * 2008-03-14 2009-09-18 Sanofi Aventis Sa Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
PE20110368A1 (es) * 2008-08-18 2011-06-13 Univ Yale Moduladores de mif
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors

Also Published As

Publication number Publication date
DK3244886T3 (da) 2022-01-17
AU2016208015A1 (en) 2017-07-06
MY187068A (en) 2021-08-28
UY36518A (es) 2016-07-29
EP3244886A1 (en) 2017-11-22
JP2018503642A (ja) 2018-02-08
US10029984B2 (en) 2018-07-24
AU2016208015B2 (en) 2020-05-07
ES2904575T3 (es) 2022-04-05
EA201791614A1 (ru) 2017-11-30
US20180002282A1 (en) 2018-01-04
SG11201705760XA (en) 2017-08-30
MA41341A (fr) 2017-11-21
EP3244886B1 (en) 2021-10-27
BR112017015123B1 (pt) 2022-11-16
MX381538B (es) 2025-03-12
ZA201704783B (en) 2019-01-30
NZ733313A (en) 2024-07-05
BR112017015123A2 (pt) 2018-03-13
PH12017501272A1 (en) 2018-01-15
KR20170103820A (ko) 2017-09-13
JP6830438B2 (ja) 2021-02-17
UA123002C2 (uk) 2021-02-03
TW201632502A (zh) 2016-09-16
PH12017501272B1 (en) 2023-01-11
CA2972329C (en) 2023-03-28
CN107428685A (zh) 2017-12-01
IL253434A0 (en) 2017-09-28
CN107428685B (zh) 2021-06-15
WO2016113371A1 (en) 2016-07-21
TWI700274B (zh) 2020-08-01
JOP20150335B1 (ar) 2022-03-14
EA032362B1 (ru) 2019-05-31
AR103412A1 (es) 2017-05-10
HK1247611A1 (zh) 2018-09-28
IL253434B (en) 2020-09-30
KR102509848B1 (ko) 2023-03-13
MX2017009309A (es) 2018-02-09
SI3244886T1 (sl) 2022-02-28
CL2017001822A1 (es) 2018-03-16
HRP20211782T1 (hr) 2022-03-04
HK1246688A1 (zh) 2018-09-14
HUE057299T2 (hu) 2022-05-28
CA2972329A1 (en) 2016-07-21

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