MA41341A - Dérivés indole utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue - Google Patents

Dérivés indole utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue

Info

Publication number
MA41341A
MA41341A MA041341A MA41341A MA41341A MA 41341 A MA41341 A MA 41341A MA 041341 A MA041341 A MA 041341A MA 41341 A MA41341 A MA 41341A MA 41341 A MA41341 A MA 41341A
Authority
MA
Morocco
Prior art keywords
dengue virus
virus replication
indole derivatives
derivatives used
replication inhibitors
Prior art date
Application number
MA041341A
Other languages
English (en)
Inventor
Dorothée Alice Marie-Eve Bardiot
Jean-François Bonfanti
Tim Hugo Maria Jonckers
Bart Rudolf Romanie Kesteleyn
Arnaud Didier M Marchand
Pierre Jean-Marie Bernard Raboisson
Original Assignee
Janssen Pharmaceuticals Inc
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Univ Leuven Kath filed Critical Janssen Pharmaceuticals Inc
Publication of MA41341A publication Critical patent/MA41341A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA041341A 2015-01-16 2016-01-14 Dérivés indole utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue MA41341A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15151481 2015-01-16

Publications (1)

Publication Number Publication Date
MA41341A true MA41341A (fr) 2017-11-21

Family

ID=52345130

Family Applications (1)

Application Number Title Priority Date Filing Date
MA041341A MA41341A (fr) 2015-01-16 2016-01-14 Dérivés indole utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue

Country Status (31)

Country Link
US (1) US10029984B2 (fr)
EP (1) EP3244886B1 (fr)
JP (1) JP6830438B2 (fr)
KR (1) KR102509848B1 (fr)
CN (1) CN107428685B (fr)
AR (1) AR103412A1 (fr)
AU (1) AU2016208015B2 (fr)
BR (1) BR112017015123B1 (fr)
CA (1) CA2972329C (fr)
CL (1) CL2017001822A1 (fr)
DK (1) DK3244886T3 (fr)
EA (1) EA032362B1 (fr)
ES (1) ES2904575T3 (fr)
HK (1) HK1247611A1 (fr)
HR (1) HRP20211782T1 (fr)
HU (1) HUE057299T2 (fr)
IL (1) IL253434B (fr)
JO (1) JOP20150335B1 (fr)
LT (1) LT3244886T (fr)
MA (1) MA41341A (fr)
MX (1) MX381538B (fr)
MY (1) MY187068A (fr)
NZ (1) NZ733313A (fr)
PH (1) PH12017501272B1 (fr)
SG (1) SG11201705760XA (fr)
SI (1) SI3244886T1 (fr)
TW (1) TWI700274B (fr)
UA (1) UA123002C2 (fr)
UY (1) UY36518A (fr)
WO (1) WO2016113371A1 (fr)
ZA (1) ZA201704783B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
JOP20160086B1 (ar) * 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) * 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
WO2017167950A1 (fr) 2016-03-31 2017-10-05 Janssen Pharmaceuticals, Inc. Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
CR20180496A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
JOP20170069B1 (ar) * 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CN109069482B (zh) 2016-04-01 2022-04-05 杨森制药公司 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar) * 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
PE20200342A1 (es) 2017-05-22 2020-02-14 Janssen Pharmaceuticals Inc Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue
MX393586B (es) 2017-05-22 2025-03-24 Janssen Pharmaceuticals Inc Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2928645A1 (fr) * 2008-03-14 2009-09-18 Sanofi Aventis Sa Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
CA2733554A1 (fr) * 2008-08-18 2010-02-25 Yale University Modulateurs de mif
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors

Also Published As

Publication number Publication date
HK1246688A1 (zh) 2018-09-14
HUE057299T2 (hu) 2022-05-28
HK1247611A1 (zh) 2018-09-28
CN107428685A (zh) 2017-12-01
JP2018503642A (ja) 2018-02-08
JOP20150335B1 (ar) 2022-03-14
DK3244886T3 (da) 2022-01-17
PH12017501272B1 (en) 2023-01-11
LT3244886T (lt) 2021-12-27
CA2972329C (fr) 2023-03-28
SI3244886T1 (sl) 2022-02-28
US20180002282A1 (en) 2018-01-04
HRP20211782T1 (hr) 2022-03-04
JP6830438B2 (ja) 2021-02-17
BR112017015123B1 (pt) 2022-11-16
MX381538B (es) 2025-03-12
US10029984B2 (en) 2018-07-24
AU2016208015A1 (en) 2017-07-06
PH12017501272A1 (en) 2018-01-15
UA123002C2 (uk) 2021-02-03
EA201791614A1 (ru) 2017-11-30
KR20170103820A (ko) 2017-09-13
NZ733313A (en) 2024-07-05
UY36518A (es) 2016-07-29
SG11201705760XA (en) 2017-08-30
KR102509848B1 (ko) 2023-03-13
MY187068A (en) 2021-08-28
IL253434A0 (en) 2017-09-28
TWI700274B (zh) 2020-08-01
IL253434B (en) 2020-09-30
WO2016113371A1 (fr) 2016-07-21
CL2017001822A1 (es) 2018-03-16
CA2972329A1 (fr) 2016-07-21
AU2016208015B2 (en) 2020-05-07
TW201632502A (zh) 2016-09-16
ES2904575T3 (es) 2022-04-05
EP3244886B1 (fr) 2021-10-27
CN107428685B (zh) 2021-06-15
BR112017015123A2 (pt) 2018-03-13
EP3244886A1 (fr) 2017-11-22
ZA201704783B (en) 2019-01-30
AR103412A1 (es) 2017-05-10
EA032362B1 (ru) 2019-05-31
MX2017009309A (es) 2018-02-09

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