LT3535B - Multinuclear complexes, contrast media containing them and use - Google Patents

Multinuclear complexes, contrast media containing them and use Download PDF

Info

Publication number
LT3535B
LT3535B LTIP609A LTIP609A LT3535B LT 3535 B LT3535 B LT 3535B LT IP609 A LTIP609 A LT IP609A LT IP609 A LTIP609 A LT IP609A LT 3535 B LT3535 B LT 3535B
Authority
LT
Lithuania
Prior art keywords
complex
atoms
medium
multinuclear
contrast
Prior art date
Application number
LTIP609A
Other languages
English (en)
Lithuanian (lt)
Inventor
Arne Berg
Torsten Almen
Klaus Dieter Krautwurst
Sook-Hui Kim
Paal Rongved
Jo Klaveness
Harald Dugstad
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of LTIP609A publication Critical patent/LTIP609A/xx
Publication of LT3535B publication Critical patent/LT3535B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
    • C07F11/005—Compounds containing elements of Groups 6 or 16 of the Periodic Table compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Liquid Crystal (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
  • Steroid Compounds (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Electric Propulsion And Braking For Vehicles (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Lubricants (AREA)
LTIP609A 1990-03-28 1993-06-03 Multinuclear complexes, contrast media containing them and use LT3535B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909006977A GB9006977D0 (en) 1990-03-28 1990-03-28 Compositions

Publications (2)

Publication Number Publication Date
LTIP609A LTIP609A (en) 1994-12-27
LT3535B true LT3535B (en) 1995-11-27

Family

ID=10673438

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP609A LT3535B (en) 1990-03-28 1993-06-03 Multinuclear complexes, contrast media containing them and use

Country Status (18)

Country Link
US (2) US5458869A (de)
EP (2) EP0521977B1 (de)
JP (1) JPH06507147A (de)
AT (1) ATE142508T1 (de)
AU (1) AU645796B2 (de)
CA (1) CA2079212A1 (de)
DE (1) DE69122092T2 (de)
DK (1) DK0521977T3 (de)
ES (1) ES2091323T3 (de)
FI (1) FI924297A7 (de)
GB (1) GB9006977D0 (de)
HK (1) HK219596A (de)
HU (2) HUT69168A (de)
LT (1) LT3535B (de)
LV (1) LV10056B (de)
NO (1) NO923739L (de)
SG (1) SG43931A1 (de)
WO (1) WO1991014460A1 (de)

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GB9006977D0 (en) * 1990-03-28 1990-05-23 Nycomed As Compositions
DE69230400T2 (de) * 1991-03-27 2000-08-03 Nycomed Salutar Inc., Wayne Kontrastmittel
US5330742A (en) * 1991-08-05 1994-07-19 Mallinckrodt Medical, Inc. Methods and compositions for magnetic resonance imaging
AU670029B2 (en) * 1991-08-05 1996-07-04 Mallinckrodt Medical, Inc. Heavy metal clusters for use as imaging agents
US5364953A (en) * 1992-11-05 1994-11-15 Mallinckrodt Medical, Inc. High relaxivity, paramagnetic, metal clusters for magnetic resonance imaging
GB9407812D0 (en) * 1994-04-20 1994-06-15 Nycomed Salutar Inc Compounds
GB9420390D0 (en) * 1994-10-10 1994-11-23 Nycomed Salutar Inc Liposomal agents
US5717121A (en) * 1995-06-07 1998-02-10 Nycomed Salutar, Inc. Preparation and use of contrast agents
GB9601340D0 (en) * 1996-01-23 1996-03-27 Nycomed Salutar Inc Contrast media
JP3839059B2 (ja) * 1996-02-14 2006-11-01 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴイ Ｘ線フィルタを有するｘ線検査装置
US5804161A (en) * 1996-05-14 1998-09-08 Nycomed Salutar Inc. Contrast agents
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
EP1140204A2 (de) 1998-12-18 2001-10-10 Du Pont Pharmaceuticals Company Vitronektin-rezeptor antagonist arzeimittheln
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
CA2349333A1 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en) 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6596259B1 (en) 1998-12-22 2003-07-22 University Of Puerto Rico Metal based cubane structure contained in an octanuclear complex stable over several oxidation states and a method of producing the same
US7807137B1 (en) 1998-12-22 2010-10-05 University Of Puerto Rico Iron-based contrast agent
US6656448B1 (en) 2000-02-15 2003-12-02 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
US6878363B2 (en) 2000-05-17 2005-04-12 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
CN1386118A (zh) 2000-06-01 2002-12-18 布里斯托尔-迈尔斯斯奎布药品公司 作为Aβ蛋白产生抑制剂的被环状琥珀酸酯取代的内酰胺类化合物
CA2427911A1 (en) 2000-11-03 2002-05-10 Bristol Myers Squibb Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
US7928278B2 (en) * 2001-06-12 2011-04-19 University Of Florida Research Foundation, Inc. Method and apparatus for producing near-infrared radiation
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US7138104B2 (en) 2001-08-08 2006-11-21 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
US7485283B2 (en) 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
JP4322781B2 (ja) * 2004-11-08 2009-09-02 富士フイルム株式会社 撮像装置
WO2007005491A1 (en) * 2005-06-30 2007-01-11 Bristol-Myers Squibb Pharma Company Hydrazide conjugates as imaging agents
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
US20070098640A1 (en) * 2005-11-02 2007-05-03 General Electric Company Nanoparticle-based imaging agents for X-ray/computed tomography
US9149545B2 (en) * 2005-11-02 2015-10-06 General Electric Company Nanoparticle-based imaging agents for X-ray/computed tomography and methods for making same
EP1991577A2 (de) 2006-01-31 2008-11-19 Parkinson, John F. Modulation der mdl-1-aktivität zur behandlung entzündlicher krankheiten
WO2009108376A2 (en) 2008-02-29 2009-09-03 Lantheus Medical Imaging, Inc. Contrast agents for applications including perfusion imaging
EP2296550B1 (de) * 2008-07-07 2018-03-28 Koninklijke Philips N.V. K-kanten-bildgebung
KR20160030589A (ko) 2009-04-15 2016-03-18 랜티우스 메디컬 이메징, 인크. 아스코르브산을 사용한 방사성 약제 조성물의 안정화
WO2011035140A1 (en) 2009-09-18 2011-03-24 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of contrast moieties to the lungs
DK3323810T3 (da) 2010-02-08 2022-03-28 Lantheus Medical Imaging Inc Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler
EP2540321A1 (de) 2011-06-30 2013-01-02 Bayer Intellectual Property GmbH Bis-Tridentat-W3O2-Cluster für Röntgenabbildung
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
EP2733148A1 (de) 2012-11-15 2014-05-21 Bayer Pharma Aktiengesellschaft Tungsten Komplexe mit di-dentate Ligands
JP6549554B2 (ja) 2013-03-15 2019-07-24 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア コレステロール流出を刺激する、減少した毒性を有するペプチド

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US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4652519A (en) 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
EP0217577A2 (de) 1985-09-12 1987-04-08 Hybritech Incorporated Antikörperkomplexe von haptenmodifizierten diagnostischen oder therapeutischen Mitteln
EP0230893A2 (de) 1986-01-30 1987-08-05 BRACCO INDUSTRIA CHIMICA Società per Azioni Paramagnetische Chelate
WO1989000557A1 (en) 1987-07-16 1989-01-26 Cockbain, Julian, Roderick, Michaelson Aminopolycarboxylic acids and derivatives thereof
US4826673A (en) 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging

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US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4652519A (en) 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4826673A (en) 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
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EP0230893A2 (de) 1986-01-30 1987-08-05 BRACCO INDUSTRIA CHIMICA Società per Azioni Paramagnetische Chelate
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Also Published As

Publication number Publication date
AU645796B2 (en) 1994-01-27
CA2079212A1 (en) 1991-09-29
DK0521977T3 (da) 1996-09-30
LV10056A (lv) 1994-05-10
JPH06507147A (ja) 1994-08-11
FI924297A0 (fi) 1992-09-25
NO923739L (no) 1992-11-06
HU9203086D0 (en) 1992-12-28
ATE142508T1 (de) 1996-09-15
US5458869A (en) 1995-10-17
HK219596A (en) 1997-01-03
GB9006977D0 (en) 1990-05-23
NO923739D0 (no) 1992-09-25
EP0521977A1 (de) 1993-01-13
WO1991014460A1 (en) 1991-10-03
DE69122092T2 (de) 1997-03-06
ES2091323T3 (es) 1996-11-01
FI924297L (fi) 1992-09-25
FI924297A7 (fi) 1992-09-25
LV10056B (en) 1995-02-20
LTIP609A (en) 1994-12-27
AU7557891A (en) 1991-10-21
EP0645146A1 (de) 1995-03-29
US5614168A (en) 1997-03-25
EP0521977B1 (de) 1996-09-11
DE69122092D1 (de) 1996-10-17
SG43931A1 (en) 1997-11-14
HUT69168A (en) 1995-08-28

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Legal Events

Date Code Title Description
TK9A Rectifications: patents

Free format text: NYCOMED IMAGING AS, NYCOVEIEN 2, P.O. BOX 4220 TORSHOV, N-0401 OSLO 4, NO, 19951130

MM9A Lapsed patents

Effective date: 19980602