LT4304B - Dozuota galeninė kompozicija vaginaliniam naudojimui kaip vietinis kontraceptikas ir/arba prieš lytiniu keliu plintančias ligas ir/arba živ - Google Patents

Dozuota galeninė kompozicija vaginaliniam naudojimui kaip vietinis kontraceptikas ir/arba prieš lytiniu keliu plintančias ligas ir/arba živ Download PDF

Info

Publication number: LT4304B
Authority: LT; Lithuania
Prior art keywords: agent; dosage; composition according; galenic composition; galenic
Prior art date: 1994-12-22

Application number

LT97-114A

Other languages

English (en)

Lithuanian (lt)

Other versions

LT97114A (en

Inventor

Catherine Meignant

Original Assignee

Laboratoire Innothera

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-22

Filing date

1997-07-04

Publication date

1998-03-25

1997-07-04 Application filed by Laboratoire Innothera filed Critical Laboratoire Innothera

1997-11-25 Publication of LT97114A publication Critical patent/LT97114A/xx

1998-03-25 Publication of LT4304B publication Critical patent/LT4304B/lt

Links

239000000203 mixture Substances 0.000 title claims abstract description 40
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
230000008602 contraction Effects 0.000 title 1
201000010099 disease Diseases 0.000 title 1
239000003795 chemical substances by application Substances 0.000 claims abstract description 44
229920000126 latex Polymers 0.000 claims abstract description 18
239000000934 spermatocidal agent Substances 0.000 claims abstract description 14
239000008384 inner phase Substances 0.000 claims abstract description 13
229920000159 gelatin Polymers 0.000 claims abstract description 12
235000019322 gelatine Nutrition 0.000 claims abstract description 12
239000007788 liquid Substances 0.000 claims abstract description 11
239000002552 dosage form Substances 0.000 claims abstract description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 46
-1 polyol esters Chemical class 0.000 claims description 36
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 33
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 24
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 23
229920002545 silicone oil Polymers 0.000 claims description 18
239000004816 latex Substances 0.000 claims description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
229960000686 benzalkonium chloride Drugs 0.000 claims description 12
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical group [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 12
239000000377 silicon dioxide Substances 0.000 claims description 12
108010010803 Gelatin Proteins 0.000 claims description 11
239000008273 gelatin Substances 0.000 claims description 11
235000011852 gelatine desserts Nutrition 0.000 claims description 11
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 9
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 9
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 9
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
208000019802 Sexually transmitted disease Diseases 0.000 claims description 8
125000005456 glyceride group Chemical group 0.000 claims description 8
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 8
239000012071 phase Substances 0.000 claims description 7
239000004094 surface-active agent Substances 0.000 claims description 7
239000000047 product Substances 0.000 claims description 6
239000000227 bioadhesive Substances 0.000 claims description 5
229920000609 methyl cellulose Polymers 0.000 claims description 5
239000001923 methylcellulose Substances 0.000 claims description 5
235000010981 methylcellulose Nutrition 0.000 claims description 5
235000009470 Theobroma cacao Nutrition 0.000 claims description 4
CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 claims description 4
239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
229960000541 cetyl alcohol Drugs 0.000 claims description 4
239000003433 contraceptive agent Substances 0.000 claims description 4
230000002254 contraceptive effect Effects 0.000 claims description 4
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 3
229960001950 benzethonium chloride Drugs 0.000 claims description 3
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 claims description 3
229920000642 polymer Polymers 0.000 claims description 3
CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical class CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 claims description 2
229920001817 Agar Polymers 0.000 claims description 2
239000002202 Polyethylene glycol Substances 0.000 claims description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
239000008272 agar Substances 0.000 claims description 2
235000010419 agar Nutrition 0.000 claims description 2
229960002233 benzalkonium bromide Drugs 0.000 claims description 2
KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 2
229920000249 biocompatible polymer Polymers 0.000 claims description 2
125000002091 cationic group Chemical group 0.000 claims description 2
229960001927 cetylpyridinium chloride Drugs 0.000 claims description 2
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 2
150000001875 compounds Chemical class 0.000 claims description 2
235000014113 dietary fatty acids Nutrition 0.000 claims description 2
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 2
LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 2
239000000194 fatty acid Substances 0.000 claims description 2
229930195729 fatty acid Natural products 0.000 claims description 2
150000004665 fatty acids Chemical class 0.000 claims description 2
239000012467 final product Substances 0.000 claims description 2
150000002334 glycols Chemical class 0.000 claims description 2
239000008240 homogeneous mixture Substances 0.000 claims description 2
GSGDTSDELPUTKU-UHFFFAOYSA-N nonoxybenzene Chemical class CCCCCCCCCOC1=CC=CC=C1 GSGDTSDELPUTKU-UHFFFAOYSA-N 0.000 claims description 2
229920002113 octoxynol Polymers 0.000 claims description 2
229920001223 polyethylene glycol Polymers 0.000 claims description 2
229920005862 polyol Polymers 0.000 claims description 2
238000003756 stirring Methods 0.000 claims description 2
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
229910000323 aluminium silicate Inorganic materials 0.000 claims 1
244000240602 cacao Species 0.000 claims 1
HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims 1
GKEMUBZAKCZMKO-UHFFFAOYSA-N ethane-1,2-diol;ethene Chemical compound C=C.OCCO GKEMUBZAKCZMKO-UHFFFAOYSA-N 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
230000002265 prevention Effects 0.000 claims 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
239000007901 soft capsule Substances 0.000 abstract description 10
239000004480 active ingredient Substances 0.000 abstract description 5
230000001150 spermicidal effect Effects 0.000 abstract description 4
230000035587 bioadhesion Effects 0.000 abstract description 3
230000002421 anti-septic effect Effects 0.000 abstract description 2
230000001050 lubricating effect Effects 0.000 abstract description 2
239000001828 Gelatine Substances 0.000 abstract 1
239000003349 gelling agent Substances 0.000 abstract 1
239000007791 liquid phase Substances 0.000 abstract 1
239000003921 oil Substances 0.000 description 11
235000019198 oils Nutrition 0.000 description 11
239000000243 solution Substances 0.000 description 8
238000012360 testing method Methods 0.000 description 6
OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
238000009472 formulation Methods 0.000 description 4
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 4
239000006216 vaginal suppository Substances 0.000 description 4
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
229920002125 Sokalan® Polymers 0.000 description 3
244000299461 Theobroma cacao Species 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
210000003756 cervix mucus Anatomy 0.000 description 3
239000004205 dimethyl polysiloxane Substances 0.000 description 3
235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
239000000314 lubricant Substances 0.000 description 3
BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 3
239000008385 outer phase Substances 0.000 description 3
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
ZWEHNKRNPOVVGH-UHFFFAOYSA-N Methyl ethyl ketone Natural products CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
QWZLBLDNRUUYQI-UHFFFAOYSA-M Methylbenzethonium chloride Chemical compound [Cl-].CC1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 QWZLBLDNRUUYQI-UHFFFAOYSA-M 0.000 description 2
229940105329 carboxymethylcellulose Drugs 0.000 description 2
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 description 2
239000000945 filler Substances 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
229960002285 methylbenzethonium chloride Drugs 0.000 description 2
VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
239000000522 vaginal cream Substances 0.000 description 2
206010046901 vaginal discharge Diseases 0.000 description 2
HNLXNOZHXNSSPN-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCOCCOCCOCCO)C=C1 HNLXNOZHXNSSPN-UHFFFAOYSA-N 0.000 description 1
CXRFDZFCGOPDTD-UHFFFAOYSA-M Cetrimide Chemical compound [Br-].CCCCCCCCCCCCCC[N+](C)(C)C CXRFDZFCGOPDTD-UHFFFAOYSA-M 0.000 description 1
UDHXJZHVNHGCEC-UHFFFAOYSA-N Chlorophacinone Chemical compound C1=CC(Cl)=CC=C1C(C=1C=CC=CC=1)C(=O)C1C(=O)C2=CC=CC=C2C1=O UDHXJZHVNHGCEC-UHFFFAOYSA-N 0.000 description 1
LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical group COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
208000031886 HIV Infections Diseases 0.000 description 1
208000037357 HIV infectious disease Diseases 0.000 description 1
229920000161 Locust bean gum Polymers 0.000 description 1
235000019482 Palm oil Nutrition 0.000 description 1
YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
230000003444 anaesthetic effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
239000003093 cationic surfactant Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
229960001275 dimeticone Drugs 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
XTEBISFIAYHLQY-UHFFFAOYSA-N ethene;2-(2-hydroxyethoxy)ethanol Chemical compound C=C.OCCOCCO XTEBISFIAYHLQY-UHFFFAOYSA-N 0.000 description 1
239000006260 foam Substances 0.000 description 1
239000000499 gel Substances 0.000 description 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
230000003902 lesion Effects 0.000 description 1
235000010420 locust bean gum Nutrition 0.000 description 1
239000000711 locust bean gum Substances 0.000 description 1
239000002075 main ingredient Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
238000000034 method Methods 0.000 description 1
229920004918 nonoxynol-9 Polymers 0.000 description 1
229940087419 nonoxynol-9 Drugs 0.000 description 1
CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
230000009965 odorless effect Effects 0.000 description 1
239000002540 palm oil Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000002952 polymeric resin Substances 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000007789 sealing Methods 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
238000010998 test method Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
229940120293 vaginal suppository Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Reproductive Health (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Gynecology & Obstetrics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Orthopedics, Nursing, And Contraception (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Drying Of Semiconductors (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Iron Core Of Rotating Electric Machines (AREA)

LT97-114A 1994-12-22 1997-07-04 Dozuota galeninė kompozicija vaginaliniam naudojimui kaip vietinis kontraceptikas ir/arba prieš lytiniu keliu plintančias ligas ir/arba živ LT4304B (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9415501A FR2728464B1 (fr)	1994-12-22	1994-12-22	Forme galenique unitaire, son procede d'obtention et ses utilisations

Publications (2)

Publication Number	Publication Date
LT97114A LT97114A (en)	1997-11-25
LT4304B true LT4304B (lt)	1998-03-25

Family

ID=9470125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LT97-114A LT4304B (lt)	1994-12-22	1997-07-04	Dozuota galeninė kompozicija vaginaliniam naudojimui kaip vietinis kontraceptikas ir/arba prieš lytiniu keliu plintančias ligas ir/arba živ

Country Status (30)

Country	Link
US (1)	US6664296B1 (da)
EP (1)	EP0784467B1 (da)
JP (1)	JP4064457B2 (da)
KR (1)	KR100373394B1 (da)
CN (1)	CN1079232C (da)
AT (1)	ATE173157T1 (da)
AU (1)	AU694306B2 (da)
BG (1)	BG62838B1 (da)
BR (1)	BR9510281A (da)
CZ (1)	CZ287057B6 (da)
DE (1)	DE69505996T2 (da)
DK (1)	DK0784467T3 (da)
EE (1)	EE03335B1 (da)
ES (1)	ES2124602T3 (da)
FI (1)	FI118372B (da)
FR (1)	FR2728464B1 (da)
GR (1)	GR3029326T3 (da)
HU (1)	HU221479B (da)
LT (1)	LT4304B (da)
LV (1)	LV11881B (da)
NO (1)	NO316208B1 (da)
NZ (1)	NZ298830A (da)
OA (1)	OA10335A (da)
PL (1)	PL182780B1 (da)
RO (1)	RO116039B1 (da)
RU (1)	RU2155582C2 (da)
SI (1)	SI9520127A (da)
SK (1)	SK280324B6 (da)
UA (1)	UA45379C2 (da)
WO (1)	WO1996019195A1 (da)

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CA2088866C (en) *	1993-02-05	2004-07-20	Daniel W. Wuerch	Non-spotting overspray masking composition
WO2001066084A2 (en) *	2000-03-07	2001-09-13	Rush-Presbyterian-St. Luke's Medical Center	Compositions and methods for trapping and inactivating pathogenic microbes and spermatozoa
US7005408B2 (en)	2002-05-01	2006-02-28	Mcneil-Ppc, Inc.	Warming and nonirritating lubricant compositions and method of comparing irritation
US7417013B2 (en)	2002-05-01	2008-08-26	Mcneil-Ppc, Inc.	Warming and nonirritating lubricant compositions and method of comparing irritation
US20040185065A1 (en) *	2002-05-01	2004-09-23	Nawaz Ahmad	Warming and nonirritating lubricant compositions and method of comparing irritation
US20040167039A1 (en) *	2002-05-01	2004-08-26	Nawaz Ahmad	Warming and nonirritating lubricant compositions and method of comparing irritation
US7695730B2 (en) *	2002-05-01	2010-04-13	Mcneil-Ppc, Inc.	Warming and nonirritating lubricant compositions and method of comparing irritation
US7658941B2 (en)	2002-05-01	2010-02-09	Johnson & Johnson Consumer Companies, Inc.	Warming and nonirritating lubricant compositions and method of comparing irritation
WO2003092652A1 (en) *	2002-05-01	2003-11-13	Mcneil-Ppc, Inc.	Warming and nonirritating anhydrous lubricant compositions
GB0418560D0 (en) *	2004-08-19	2004-09-22	Ssl Int Plc	Lubricant delivery
US20060188528A1 (en) *	2005-02-23	2006-08-24	Ansell Healthcare Products Llc	Spreadable warming lubricant
US7709428B2 (en) *	2005-02-23	2010-05-04	Ansell Healthcare Products Llc	Thickened spreadable warming lubricant
KR100738188B1 (ko) *	2005-06-20	2007-07-10	벤자민 원 박	증류수와 수용성고분자로부터 제조된 피임젤 조성물
KR100775315B1 (ko) *	2005-08-03	2007-11-08	벤자민 원 박	성병과 에이즈예방용 윤활젤 조성물
WO2006112632A1 (en) *	2005-04-18	2006-10-26	Benjamin Won Park	Urethral condoms and liquid femidoms
US7851419B2 (en) *	2005-09-12	2010-12-14	Nawaz Ahmad	Substantially anhydrous sprayable personal lubricant
US20070281008A1 (en) *	2006-06-05	2007-12-06	Lin Shun Y	Personal lubricant compositions and kits for providing personal lubrication
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1994
- 1994-12-22 FR FR9415501A patent/FR2728464B1/fr not_active Expired - Fee Related
1995
- 1995-12-21 CZ CZ19971921A patent/CZ287057B6/cs not_active IP Right Cessation
- 1995-12-21 BR BR9510281A patent/BR9510281A/pt not_active IP Right Cessation
- 1995-12-21 UA UA97073838A patent/UA45379C2/uk unknown
- 1995-12-21 AU AU44511/96A patent/AU694306B2/en not_active Expired
- 1995-12-21 DE DE69505996T patent/DE69505996T2/de not_active Expired - Lifetime
- 1995-12-21 JP JP51956796A patent/JP4064457B2/ja not_active Expired - Lifetime
- 1995-12-21 RU RU97112388/14A patent/RU2155582C2/ru active
- 1995-12-21 EP EP95943257A patent/EP0784467B1/fr not_active Expired - Lifetime
- 1995-12-21 PL PL95320884A patent/PL182780B1/pl not_active IP Right Cessation
- 1995-12-21 NZ NZ298830A patent/NZ298830A/en not_active IP Right Cessation
- 1995-12-21 RO RO97-01143A patent/RO116039B1/ro unknown
- 1995-12-21 EE EE9700148A patent/EE03335B1/xx not_active IP Right Cessation
- 1995-12-21 WO PCT/FR1995/001712 patent/WO1996019195A1/fr not_active Ceased
- 1995-12-21 AT AT95943257T patent/ATE173157T1/de active
- 1995-12-21 KR KR1019970704240A patent/KR100373394B1/ko not_active Expired - Lifetime
- 1995-12-21 SI SI9520127A patent/SI9520127A/sl not_active IP Right Cessation
- 1995-12-21 HU HU9702284A patent/HU221479B/hu not_active IP Right Cessation
- 1995-12-21 DK DK95943257T patent/DK0784467T3/da active
- 1995-12-21 SK SK777-97A patent/SK280324B6/sk not_active IP Right Cessation
- 1995-12-21 US US08/860,222 patent/US6664296B1/en not_active Expired - Fee Related
- 1995-12-21 CN CN95196932A patent/CN1079232C/zh not_active Expired - Lifetime
- 1995-12-21 ES ES95943257T patent/ES2124602T3/es not_active Expired - Lifetime
1996
- 1996-11-01 OA OA60915A patent/OA10335A/fr unknown
1997
- 1997-06-19 FI FI972642A patent/FI118372B/fi not_active IP Right Cessation
- 1997-06-20 NO NO19972899A patent/NO316208B1/no not_active IP Right Cessation
- 1997-06-24 BG BG101660A patent/BG62838B1/bg unknown
- 1997-07-01 LV LVP-97-120A patent/LV11881B/xx unknown
- 1997-07-04 LT LT97-114A patent/LT4304B/lt not_active IP Right Cessation
1999
- 1999-02-10 GR GR990400412T patent/GR3029326T3/el unknown

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FR2372635A1 (fr)	1976-12-03	1978-06-30	Scherer Ltd R P	Nouvelle composition pharmaceutique contenant une huile auto-emulsionnante
US4187286A (en)	1979-01-02	1980-02-05	G&W Laboratories, Inc.	Contraceptive suppository
EP0121321A2 (en)	1983-03-02	1984-10-10	R.P. Scherer Corporation	Pharmaceutical compositions
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Also Published As

Publication number	Publication date
RU2155582C2 (ru)	2000-09-10
HUT77365A (hu)	1998-03-30
OA10335A (fr)	1997-10-07
FI972642L (fi)	1997-08-18
JP4064457B2 (ja)	2008-03-19
CZ192197A3 (en)	1997-11-12
CZ287057B6 (en)	2000-08-16
NO316208B1 (no)	2003-12-29
ATE173157T1 (de)	1998-11-15
SI9520127A (sl)	1998-02-28
FI972642A0 (fi)	1997-06-19
KR100373394B1 (ko)	2003-05-16
EE03335B1 (et)	2001-02-15
SK77797A3 (en)	1998-01-14
BG101660A (bg)	1998-02-27
NO972899L (no)	1997-08-18
US6664296B1 (en)	2003-12-16
EP0784467A1 (fr)	1997-07-23
FI118372B (fi)	2007-10-31
BG62838B1 (bg)	2000-09-29
PL182780B1 (pl)	2002-02-28
NZ298830A (en)	1998-11-25
SK280324B6 (sk)	1999-11-08
CN1079232C (zh)	2002-02-20
DE69505996T2 (de)	1999-05-27
RO116039B1 (ro)	2000-10-30
HU221479B (en)	2002-10-28
DE69505996D1 (de)	1998-12-17
JPH11501292A (ja)	1999-02-02
LT97114A (en)	1997-11-25
ES2124602T3 (es)	1999-02-01
FR2728464B1 (fr)	1997-04-30
LV11881B (lv)	1998-07-20
WO1996019195A1 (fr)	1996-06-27
EP0784467B1 (fr)	1998-11-11
LV11881A (lv)	1997-12-20
PL320884A1 (en)	1997-11-10
DK0784467T3 (da)	1999-07-26
BR9510281A (pt)	1998-01-06
UA45379C2 (uk)	2002-04-15
NO972899D0 (no)	1997-06-20
CN1170354A (zh)	1998-01-14
AU4451196A (en)	1996-07-10
GR3029326T3 (en)	1999-05-28
AU694306B2 (en)	1998-07-16
FR2728464A1 (fr)	1996-06-28

Legal Events

Date	Code	Title	Description
2013-07-25	MM9A	Lapsed patents	Effective date: 20121221

Publication	Publication Date	Title
LT4304B (lt)	1998-03-25	Dozuota galeninė kompozicija vaginaliniam naudojimui kaip vietinis kontraceptikas ir/arba prieš lytiniu keliu plintančias ligas ir/arba živ
RU97112388A (ru)	1999-06-10	Дозированная галенова композиция для вагинального применения в качестве местного контрацептивного средства и/или для борьбы с заболеваниями, передающимися половым путем, и/или вич
US8303969B2 (en)	2012-11-06	Spreadable warming lubricant
EP0386960A2 (en)	1990-09-12	Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings
AU2005327970A1 (en)	2006-08-31	Thickened spreadable warming lubricant
US20130184245A1 (en)	2013-07-18	Endometriosis treatment
JPH07148195A (ja)	1995-06-13	コンドーム
CA2208436C (fr)	2007-05-22	Association therapeutique vitamino-calcique sous forme galenique unitaire destinee a la voie vaginale utilisable comme contraceptif local et/ou pour combattre les maladies sexuellement transmissibles et/ou les vih
JPH04227257A (ja)	1992-08-17	殺精子剤付きコンドーム