LT4628B - Cefalosporano 7beta-(4-karboksibutanamido)rūgšties fermentinis gavimo būdas, panaudojant modifikuotą trigonopsis variabilis d-aminorūgšties oksidazės fermentą, produkuotą escherichia coli - Google Patents

Cefalosporano 7beta-(4-karboksibutanamido)rūgšties fermentinis gavimo būdas, panaudojant modifikuotą trigonopsis variabilis d-aminorūgšties oksidazės fermentą, produkuotą escherichia coli Download PDF

Info

Publication number: LT4628B
Authority: LT; Lithuania
Prior art keywords: enzyme; amino acid; acid oxidase; gene; dna
Prior art date: 1997-09-25

Application number

LT99-051A

Other languages

English (en)

Lithuanian (lt)

Other versions

LT99051A (en

Inventor

Jose Luis Garcia-Lopez

Estrella Cortes-Rubio

Jorge Alonso-Palacios

Encarnacion Mellado-Duran

Bruno Diez-Garcia

Jose Manuel Guisan-Seijas

Francisco Salto-Maldonado

Jose Luis Barredo-Fuente

Original Assignee

Antibioticos S.A.U.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-25

Filing date

1999-05-11

Publication date

2000-02-25

1999-05-11 Application filed by Antibioticos S.A.U. filed Critical Antibioticos S.A.U.

1999-10-25 Publication of LT99051A publication Critical patent/LT99051A/xx

2000-02-25 Publication of LT4628B publication Critical patent/LT4628B/lt

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BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
229960000318 kanamycin Drugs 0.000 description 1
229930027917 kanamycin Natural products 0.000 description 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
229930182823 kanamycin A Natural products 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
238000011068 loading method Methods 0.000 description 1
230000001320 lysogenic effect Effects 0.000 description 1
239000003550 marker Substances 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
229910021645 metal ion Inorganic materials 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
108091033319 polynucleotide Proteins 0.000 description 1
102000040430 polynucleotide Human genes 0.000 description 1
239000002157 polynucleotide Substances 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
230000012743 protein tagging Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000012216 screening Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
238000010186 staining Methods 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
230000005030 transcription termination Effects 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000013519 translation Methods 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
- C12N9/0024—D-Amino acid oxidase (1.4.3.3)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/06—Cephalosporin C; Derivatives thereof

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Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

LT99-051A 1997-09-25 1999-05-11 Cefalosporano 7beta-(4-karboksibutanamido)rūgšties fermentinis gavimo būdas, panaudojant modifikuotą trigonopsis variabilis d-aminorūgšties oksidazės fermentą, produkuotą escherichia coli LT4628B (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES009702008A ES2131018B1 (es)	1997-09-25	1997-09-25	Un procedimiento enzimatico para preparar acido 7beta-(4-carboxibutanamido)cefalosporanico utilizando la enzima d-aminoacido oxidasa de trigonopsis variabilis modificada producida en escherichia coli.

Publications (2)

Publication Number	Publication Date
LT99051A LT99051A (en)	1999-10-25
LT4628B true LT4628B (lt)	2000-02-25

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Application Number	Title	Priority Date	Filing Date
LT99-051A LT4628B (lt)	1997-09-25	1999-05-11	Cefalosporano 7beta-(4-karboksibutanamido)rūgšties fermentinis gavimo būdas, panaudojant modifikuotą trigonopsis variabilis d-aminorūgšties oksidazės fermentą, produkuotą escherichia coli

Country Status (17)

Country	Link
US (1)	US6635458B2 (cs)
EP (1)	EP0969088A1 (cs)
JP (1)	JP2001506868A (cs)
KR (1)	KR20000069110A (cs)
CN (1)	CN1246147A (cs)
AU (1)	AU9162898A (cs)
CA (1)	CA2272354A1 (cs)
CZ (1)	CZ182399A3 (cs)
EE (1)	EE9900205A (cs)
ES (1)	ES2131018B1 (cs)
HU (1)	HUP0000797A2 (cs)
IL (1)	IL129533A0 (cs)
LT (1)	LT4628B (cs)
LV (1)	LV12359B (cs)
SK (1)	SK64899A3 (cs)
WO (1)	WO1999015632A1 (cs)
ZA (1)	ZA988754B (cs)

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CN100342014C (zh) *	2004-04-08	2007-10-10	百瑞全球有限公司	重组d－氨基酸氧化酶
CN1912130B (zh) *	2005-08-08	2011-06-15	百瑞全球有限公司	一种用于制备7-氨基头孢霉烷酸的两步酶法
CN101016540B (zh) *	2006-02-10	2010-04-07	台湾尖端先进生技医药股份有限公司	C-端含有组氨酸标记的hoxb4重组蛋白质的制造方法及用途
RU2412998C1 (ru) *	2009-11-18	2011-02-27	Общество с ограниченной ответственностью "Инновации и высокие технологии МГУ"	Мутантная оксидаза d-аминокислот

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EP0583817A2 (en)	1992-07-27	1994-02-23	Asahi Kasei Kogyo Kabushiki Kaisha	A transformant capable of producing D-amino acid oxidase
JPH071180A (ja)	1993-04-30	1995-01-06	Westinghouse Electric Corp <We>	溶加線材用組成物
ES2109194A1 (es)	1996-04-22	1998-01-01	Antibioticos Sa	Un procedimiento para producir la enzima d-aminoacido oxidasa de rhodotorula gracilis en celulas hospedantes.

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CA1340522C (en) *	1987-03-10	1999-05-04	Heinz Dobeli	Fusion proteins containing neighbouring histidines for improved purification

1997
- 1997-09-25 ES ES009702008A patent/ES2131018B1/es not_active Expired - Fee Related
1998
- 1998-09-23 ZA ZA988754A patent/ZA988754B/xx unknown
- 1998-09-24 EP EP98943898A patent/EP0969088A1/en not_active Withdrawn
- 1998-09-24 JP JP51859999A patent/JP2001506868A/ja not_active Ceased
- 1998-09-24 WO PCT/ES1998/000262 patent/WO1999015632A1/es not_active Ceased
- 1998-09-24 CZ CZ991823A patent/CZ182399A3/cs unknown
- 1998-09-24 EE EEP199900205A patent/EE9900205A/xx unknown
- 1998-09-24 SK SK648-99A patent/SK64899A3/sk unknown
- 1998-09-24 KR KR1019997004579A patent/KR20000069110A/ko not_active Ceased
- 1998-09-24 AU AU91628/98A patent/AU9162898A/en not_active Abandoned
- 1998-09-24 CA CA002272354A patent/CA2272354A1/en not_active Abandoned
- 1998-09-24 CN CN98801336A patent/CN1246147A/zh active Pending
- 1998-09-24 HU HU0000797A patent/HUP0000797A2/hu unknown
- 1998-09-24 US US09/308,683 patent/US6635458B2/en not_active Expired - Fee Related
- 1998-09-24 IL IL12953398A patent/IL129533A0/xx unknown
1999
- 1999-05-11 LT LT99-051A patent/LT4628B/lt not_active IP Right Cessation
- 1999-05-25 LV LVP-99-87A patent/LV12359B/en unknown

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EP0583817A2 (en)	1992-07-27	1994-02-23	Asahi Kasei Kogyo Kabushiki Kaisha	A transformant capable of producing D-amino acid oxidase
JPH071180A (ja)	1993-04-30	1995-01-06	Westinghouse Electric Corp <We>	溶加線材用組成物
ES2109194A1 (es)	1996-04-22	1998-01-01	Antibioticos Sa	Un procedimiento para producir la enzima d-aminoacido oxidasa de rhodotorula gracilis en celulas hospedantes.

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Also Published As

Publication number	Publication date
CN1246147A (zh)	2000-03-01
HUP0000797A2 (en)	2000-07-28
ZA988754B (en)	1999-06-28
US6635458B2 (en)	2003-10-21
WO1999015632A1 (es)	1999-04-01
CZ182399A3 (cs)	1999-09-15
JP2001506868A (ja)	2001-05-29
ES2131018B1 (es)	2000-04-01
AU9162898A (en)	1999-04-12
EP0969088A1 (en)	2000-01-05
ES2131018A1 (es)	1999-07-01
KR20000069110A (ko)	2000-11-25
CA2272354A1 (en)	1999-04-01
IL129533A0 (en)	2000-02-29
SK64899A3 (en)	2000-05-16
LT99051A (en)	1999-10-25
US20030119087A1 (en)	2003-06-26
EE9900205A (et)	1999-12-15
LV12359A (lv)	1999-10-20
LV12359B (en)	2000-03-20

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Date	Code	Title	Description
2002-05-27	MM9A	Lapsed patents	Effective date: 20010924

Publication	Publication Date	Title
RU2103364C1 (ru)	1998-01-27	Последовательность днк, белок и способ получения белка
KR100506134B1 (ko)	2005-08-08	신규한 카르보닐 환원효소 및 이것을 코딩하는 유전자 및 이러한 환원효소 및 유전자 이용방법
JPWO1998035025A1 (ja)	2000-07-11	新規カルボニル還元酵素、およびこれをコードする遺伝子、ならびにこれらの利用方法
JP4248900B2 (ja)	2009-04-02	新規なフルクトシルアミンオキシダーゼをコードする遺伝子及びそれを用いての該フルクトシルアミンオキシダーゼの製造方法
CN109852644B (zh)	2023-04-07	一种制备布瓦西坦中间体的方法
EP0877084B1 (en)	2005-03-09	Thermostable diaphorase gene
LT4628B (lt)	2000-02-25	Cefalosporano 7beta-(4-karboksibutanamido)rūgšties fermentinis gavimo būdas, panaudojant modifikuotą trigonopsis variabilis d-aminorūgšties oksidazės fermentą, produkuotą escherichia coli
CZ348096A3 (en)	1997-07-16	Actinomycetic promoter
KR100543051B1 (ko)	2006-01-20	푸코스 황산 함유 다당 분해 활성을 가지는 폴리펩티드를암호화하는 유전자
US7399624B2 (en)	2008-07-15	Cephalosporin C acylases
US6187574B1 (en)	2001-02-13	Process for producing the enzyme D-amino acid oxidase of Rhodotorula gracilis in host cells
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CA2377793A1 (en)	2001-01-11	Gene encoding cyclic lipopeptide acylase and expression of the same
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MXPA99004513A (en)	2000-02-02	ENZYMATIC PROCESS FOR THE PREPARATION OF CEPHALOSPORANIC 7$b(g)-(4-CARBOXYBUTANAMIDE) ACID BY MEANS OF THE MODIFIED ENZYME D-AMINOACID OXIDASE OF TRIGONOPSIS VARIABILIS
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