LT4864B - Sapropelio trąšos ir jų gavimo būdas - Google Patents

Sapropelio trąšos ir jų gavimo būdas Download PDF

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LT4864B
LT4864B LT2001004A LT2001004A LT4864B LT 4864 B LT4864 B LT 4864B LT 2001004 A LT2001004 A LT 2001004A LT 2001004 A LT2001004 A LT 2001004A LT 4864 B LT4864 B LT 4864B
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sapropel
peat
fertilizer
mixture
fertilizers
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Evaldas Gei�Toraitis
Antanas Ci�Nys
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Evaldas Gei�Toraitis
Antanas Ci�Nys
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Description

Išradimas priklauso trąšų gamybos sričiai, būtent organinių trąšų mišiniams, į kurių sudėtį įeina sapropelis ir jų gavimo būdui. Šiuo būdu gautos trąšos naudojamos efektyviam dirvų tręšimui.
Sapropelis - tai ežerų dugne, esant deguonies trūkumui, iš tirpių ir kietų nuosėdų, veikiant biologiniamš procesams, per kelis tūkstantmečius susiformavusi organinė medžiaga. Seniai yra žinomas organinio sapropelio panaudojimas žemės ūkyje (L. Katkevičius, A. Ciūnys, E. Bakšienė Ežerų sapropelis žemės ūkiui”, Vilnius, 1998).
Žinomas organmineralinių sapropelio trąšų gavimo būdas, kai sapropelio pulpą sutirština nusodintuve, pašalina pagrindinę nuskaidrinto vandens masę ir į sutirštintą sapropelio pulpą deda mineralinius priedus, būtent skalūnų pelenus (buv. TSRS a.l. Nr. 1724657).
Aprašyto sapropelio trąšų gavimo būdo trūkumas yra ilgai trunkantis šių trąšų paruošimas, o šiuo būdu gautos trąšos lėtai mineralizuojasi ir maisto medžiagas atiduoda palaipsniui, be to, šiose trąšose yra mažai hidrolizuojamų medžiagų.
Žinomos sapropelio trąšos, susidedančios iš sapropelio ir organinių ir/arba mineralinių priedų, kaip organiniai priedai gali būti durpės ir/arba skiedros, ir/arba pjuvenos, ir u.oa mėšlas, o kaip mineraliniai priedai gali būti ceolitas ir/arba mineralinės trąšos, ir/arba šlakas, ir/arba karbonatinis sapropelis. Sapropelio trąšose priedai sudaro nurodytus masės % : durpės su drėgminiu imlumu 1000% 30;Fosforo trąšos 0,4
Kalio trąšos 0,2
Azoto trąšos 0,25
Likusi dalis: Karbonatinis sapropelis (Rusijos patentas Nr. 2041866, 1994 01 20, C05F 7/00).
Žinomas sapropelio trąšų gavimo būdas, kai išimtą iš ežero sapropelį aikštelėje paskleidžia sluoksniu ir periodiškai maišant džiovina pridedant priedų. Žiemą sapropelį šaldo ir sudeda į m aukščio krūvas, kad pavasarį po šalčių sapropelio masės drėgnis būtų apie 40 %
Maišymo metu į sapropelį įveda mineralinius ir/arba organinius priedus, tokius kaip durpes, 2 LT 4864 B ir/arba skiedras, ir/arba pjuvenas, ir/arba ceolitą, ir/arba mineralines trąšas, ir/arba šlaką, ir/arba karbonatinį sapropelį. Po to sapropelį valo nuo pašalinių priemaišų, mala, džiovina iki jo drėgnis siekia 10-40% bei granuliuoja (Rusijos patentas Nr. 2041866, 1994 01 20, C05F 7/00).
Žinomose sapropelio trąšose dedama 30 masės % durpių su drėgminiu imlumu 1000%, tai atitinka sausosios medžiagos durpių 9 masės %. Žinomo sapropelio trąšų gavimo būdas ilgas ir brangus, nes šiuo būdu gautų trąšų kompozicijoje esantis mineralinių ir organinių medžiagų masių santykis neužtikrina greito sapropelio trąšų džiovinimo proceso, be to, reikalinga įranga trąšų malimui, granuliavimui bei jų pergabenimui nuo vienos apdorojimo operacijos prie kitos. Gautos šiuo būdu trąšos nepakankamai efektyvios, nes granulėse esančios maisto medžiagos lėtai atiduodamos dėl mažo granulių vandens imlumo.
Išradimu siekiama supaprastinti sapropelio trąšų gavimo būdą bei pagerinti sapropelio trąšų efektyvumą.
Uždavinio sprendimo esmė yra ta, kad sapropelio trąšose, susidedančiose iš sapropelio ir durpių mišinio, nauja yra tai, kad sapropelio ir durpių sausųjų medžiagų masių santykis mišinyje yra ribose nuo 1 : 1 iki 1 : 0,5.
Sapropelio gavimo būde, apimančiame sapropelio išėmimą iš ežero, jo paskleidimą sluoksniu aikštelėje, džiovinimą ir džiovinimo metu periodiškai maišant organinių priedų, pavyzdžiui, durpių į sapropelį įvedimą, nauja yra tai, kad sapropelio ir durpių sausųjų medžiagų masių santykį mišinyje palaiko ribose nuo 1 : 1 iki 1 : 0,5.
Sapropelio džiovinimo metu jo sumaišymas su durpėmis užtikrinant sausųjų medžiagų masių santykį nuo 1 : 1 iki 1 : 0,5 pagreitina sapropelio džiovinimą, tuo pačiu ir sapropelio trąšų gavimą bei pagerina gautų trąšų efektyvumą. Gauta mišinio masė puri, biri, struktūringa, pasižymi geromis absorbcinėmis sąvybėmis. Šis trąšų gamybos būdas yra pigus, jo realizavimas nereikalauja sudėtingos įrangos. Gautose trąšose esanti durpių dalis pagreitina sapropelio mineralizaciją, padidina lengvai hidrolizuojamų medžiagų bei humusinių rūgščių kiekį, o esanti sapropelio dalis sulėtina durpių mineralizaciją, neleidžia išgaruoti išsiskiriančioms augalų maisto medžiagoms
Trąšų optimalus džiovinimo laikas ir trąšų efektyvumas buvo nustatytas įvertinus žemiau aprašytus bandymus.
Bandymais buvo nustatyti sapropelio, durpių bei šių medžiagų mišinių džiovinimo duomenys, kurie pateikti 1 lentelėje.
lentelė
Bandymų variantai Būklė Džiovinimo laikas paromis' ir medžiagos drėgnis %
Šviežias 5 paros 10 parų 20 parų 30 parų 40
parų
1. Sapropelis (S) Tešlos 92 91 86 79 72 64
Konsist.
2. Durpės (D) Puri 73 69 47 34 27 28
3. S+D 1:1 Tirštos 89 87 81 69 56 51
tesi. kons.
4. S+D 1:2 Biri 87 84 70 62 54 48
5. S+D 1:3 Puri 82 79 63 55 49 36
6. S+D 1:0,5 Tirštos 90 89 84 73 66 58
Tešlos
konsist.
lentelės duomenys rodo, kad sumaišytas sapropelis su durpėmis greičiau džiūsta ir jo struktūra pasidaro puri. Greičiausiai džiūsta durpės ir tas mišinys, kur durpių daugiausiai, t.y. S+D 1:3. Tačiau šis sapropelio ir durpių santykis nėra efektyviausias augalams. Siekiant įvertinti sapropelio ir durpių bei jų mišinio kaip trąšų vertingumą, buvo atlikti bandymai, nustatant šių medžiagų toksiškumą. Kuo mažesnis trąšų toksiškumas, tuo didesni augalų dygimo energija, daigumas ir augimas. Pagal Valstybinį standartąNr.5055-56 buvo nustatyta agurkų veislės “Alfa” sėklų dygimo energija ir daigumas. Escherichia coli bakterinė kultūra buvo įvesta į vandeninę tiriamosios medžiagos ištrauką santykiu (1 : 1). Bandymo rezultatai pateikti 2 lentelėje.
lentelė. Sapropelio - durpių trąšų vertingumo nustatymas
Bandymų variantai Dygimo energija % Daigumas % Augimas pagal E.c.
1. Sapropelis (S) +9 +12 +2
2. Durpės (D) +3 1 -2 -2
3. S + D 1:1 +6 +5 +4
4. S + D 1:2 +3 +3 +3
5. S + D 1:3 +2 +1 +1
6. S + D 1:0,5 +8 +7 +5
lentelės duomenys rodo, kad efektyviausia trąša yra sapropelio ir durpių mišinys 1 : 0,5, tačiau šios trąšos lėtokai džiūsta. Įvertinus abiejų lentelių duomenis buvo nustatyta, kad geriausias trąšų efektyvumas ir palygint neilgas džiovinimo laikas pasiekiam·- Yiant sapropelį su durpėmis sausųjų medžiagų masės santykiu apie 1:1. Toks mišinys gerai išdžiūsta ir gaunama efektyvi trąša.
Pasiūlytos sapropelio trąšos susideda iš sapropelio ir durpių mišinio, kuriame sapropelio ir durpių sausųjų medžiagų masių santykis mišinyje yra nuo 1 : 1 iki 1 : 0,5.
Trąšų gavimo būdas. Nustatomas pradinių medžiagų t.y. sapropelio ir durpių, iš kurių bus gaminamos trąšos, drėgnis. Žinomais literatūroje aprašytais būdais (payzdžiui, sapropelio sausųjų medžiagų kiekis, esant skirtingam žaliavos drėgniui, yra pateiktas grafiko pavidale knygoje L. Katkevičius, A. Ciūnys, E. Bakšienė “Ežerų sapropelis žemės ūkiui”, Vilnius, 1998, 50 psl.) nustatomas santykis tarp atitinkamo drėgnio žaliavos ir sausųjų medžiagų kiekio. Sis santykis pateikiamas 3 lentelėje.
lentelė.
Žaliavos drėgnis, %. Sausųjų medžiagų kiekis, kg/mJ
90% 100 kg/m3
80% 220 kg/m3
70% 360 kg/m3
65% 590 kg/m3
50% 670 kg/m3
40% 820 kg/ m3
30% . 960 kg/m3
Pagal pateiktą lentelę, esant sapropelio drėgniui 70%, sausųjų medžiagų kiekis yra 360 kg/m3, o durpių drėgniui esant apie 40%, sausųjų medžiagų kiekis yra 820 kg/m3, todėl, norint pasiekti minėtų sausųjų medžiagų santykį 1:1, sapropelio kiekį reikia padidinti ne mažiau kaip dvigubai. Esant nurodytam pradinių medžiagų drėgmiui dedama 1 m3 durpių ir 2 m3 sapropelio, po to nurodytu santykiu sudėtos medžiagos mechaniškai sumaišomos. Vėliau mišinys džiovinamas apie 15 parų, kol mišinio drėgnis pasiekia apie 50%.
Pasiūlytų sapropelio trąšų gavimo būdas detaliau paiškintas pateiktuoses pavyzdžiuose.
pavyzdys. Valant užpelkėjusius ežerus iškasamos durpės, kurios būna susiformavusios ežerų pakraščiuose. Durpės vienkaušiu ekskavatoriumi supilamos ant kranto į 2 - 3 m aukščio krūvas. Durpės krūvose greitai išdžiūsta (po 20 dienų jų drėgnis siekia 30 — 4u ir gali būti naudojamos trąšoms gaminti.
Sapropelis kuopiamas atskirai, dažniausiai pulpos pavidale siurbiamas žemsiurbe .> ir plastmasiniais vamzdžiais arba polietileninėmis rankovėmis (žarnomis) transportuojamas į sėsdintuvus, kur supilamas 0,5 m storio sluoksniu. Nuleidus iš sėsdintuvo vandenį sapropelio drėgnis siekia 80 - 85%.
Išdžiūvusios durpės vežamos prie sėsdintuvų, pilamos 0,3 - 0,4 m storio sluoksniu ant sapropelio sluoksnio ir ekskavatoriumi su juo sumaišomos. Po to mišinys dar džiovinamas apie 15 parų. Kai jo drėgnis siekia apie 50%, trąšų mišinys gali būti fasuojamas arba išvežamas autotransportu laukams tręšti.
pavyzdys. Sapropelio ir durpių gavyba vykdoma analogiškai aprašytam pirmajame pavyzdyje. Sapropelis sėsdintuve paliekamas džiūti 15-18 parų, kol jo paviršius sutrūkinėja (jo drėgnis siekia apie 70%). Prie sėsdintuvo atvežamos sausos durpės. Sapropelio ir durpių 6 LT 4864 B maišymas vykdomas betono (ar panašia) maišykle (apie 2/3 tūrio sudaro sapropelis, 1/3 durpės, kad sausųjų medžiagos santykis išliktų 1:1). Mišinio drėgnis siekia 50 - 45%. Po kelių (5-8) parų drėgmė dar sumažėja, mišinys pasidaro purus, birus, jo granulių dydis 0,3 0,8 cm. Mišinys fasuojamas į maišelius.
pavyzdys. Užpelkėjusioje ežero pakrantėje pradžioje vienkaušiu ekskavatoriumi kasamos durpės ir supilamos į 2 - 3 m aukščio krūvas. Po to iš gilesnių sluoksnių kasamos žemiau esantis sapropelis, kraunamas į traktorines priekabas ir išvežamas į sandėliavimo aikštelę, kur paskleidžiamas 0,5 m storio sluoksniu. Po 10 parų sapropelio paviršius sutrūkinėja, jo drėgnis siekia apie 70 %. Tuomet atvežamos išdžiūvusios durpės ir maišomos su sapropeliu pirmajame arba antrajame pavyzdžiuose aprašytu būdu.

Claims (2)

  1. IŠRADIMO APIBRĖŽTIS
    1. Sapropelio trąšos, susidedančios iš sapropelio ir durpių mišinio, besiskiriančios tuo, kad sapropelio ir durpių sausųjų medžiagų masių santykis mišinyje yra nuo 1 : 1 iki
    1 : 0,5.
  2. 2. Sapropelio trąšų pagal 1 punktą gavimo būdas, apimantis sapropelio išėmimą iš ežero, jo paskleidimą sluoksniu aikštelėje, džiovinimą ir džiovinimo metu, periodiškai maišant, durpių įvedimą į sapropelį, besiskiriantis tuo, kad sapropelio ir durpių sausųjų medžiagų masių santykį mišinyje palaiko nuo 1 : 1 iki 1 : 0,5.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT6043B (lt) 2012-08-27 2014-06-25 Uab "Mibarsas" Organinės trąšos sapropelio pagrindu ir jų gamybos būdas
LT7101B (lt) 2024-01-16 2024-10-25 Steponavičius Petras Organinės trąšos sapropelio pagrindu ir jų gamybos būdas, panaudojant susmulkintus šiaudus, aukštapelkines durpes ir hidrogelį

Families Citing this family (246)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
PT1094816E (pt) * 1998-07-06 2009-03-10 Bristol Myers Squibb Co Sulfonamidas bifenílicas duplamente antagonistas receptores de angiotensina e endotelina
MY125533A (en) 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
EP1741713A3 (en) * 1999-12-15 2009-09-09 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
WO2001049289A1 (en) * 1999-12-31 2001-07-12 Texas Biotechnology Corporation Pharmaceutical and veterinary uses of endothelin antagonists
US6271228B1 (en) * 2000-04-28 2001-08-07 Pfizer Inc. Blood pressure stabilization during hemodialysis
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
JP2004514703A (ja) * 2000-12-01 2004-05-20 ノバルティス　アクチエンゲゼルシャフト 有機化合物の組合せ剤
EP1427415B1 (en) 2001-09-21 2009-08-12 Brystol-Myers Squibb Company Lactam-containing compounds and derivatives thereof as factor xa inhibitors
US7238671B2 (en) 2001-10-18 2007-07-03 Bristol-Myers Squibb Company Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
KR20040054729A (ko) 2001-10-18 2004-06-25 브리스톨-마이어스 스큅 컴퍼니 인간 글루카곤-유사-펩티드-1 모방체, 및 당뇨병 및 이와관련된 증상의 치료에 있어서 이의 용도
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US6831102B2 (en) 2001-12-07 2004-12-14 Bristol-Myers Squibb Company Phenyl naphthol ligands for thyroid hormone receptor
TWI328007B (en) * 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
TW200307539A (en) 2002-02-01 2003-12-16 Bristol Myers Squibb Co Cycloalkyl inhibitors of potassium channel function
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
US7435824B2 (en) 2002-04-19 2008-10-14 Bristol-Myers Squibb Company Prodrugs of potassium channel inhibitors
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7057046B2 (en) 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
MY139563A (en) 2002-09-04 2009-10-30 Bristol Myers Squibb Co Heterocyclic aromatic compounds useful as growth hormone secretagogues
ATE469645T1 (de) 2002-10-23 2010-06-15 Bristol Myers Squibb Co Auf glycinnitril basierende hemmer der dipeptidylpeptidase iv
US7098235B2 (en) 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
EP1567487A4 (en) 2002-11-15 2005-11-16 Bristol Myers Squibb Co OPEN-CHAINED, PROLYL-FROSTED MODULATORS OF ANDROGEN RECEPTOR FUNCTION
TW200504021A (en) 2003-01-24 2005-02-01 Bristol Myers Squibb Co Substituted anilide ligands for the thyroid receptor
US6846836B2 (en) 2003-04-18 2005-01-25 Bristol-Myers Squibb Company N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase
US7557143B2 (en) 2003-04-18 2009-07-07 Bristol-Myers Squibb Company Thyroid receptor ligands
US6995183B2 (en) 2003-08-01 2006-02-07 Bristol Myers Squibb Company Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7378426B2 (en) 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7772232B2 (en) 2004-04-15 2010-08-10 Bristol-Myers Squibb Company Quinazolinyl compounds as inhibitors of potassium channel function
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US7534763B2 (en) 2004-07-02 2009-05-19 Bristol-Myers Squibb Company Sustained release GLP-1 receptor modulators
US7145040B2 (en) 2004-07-02 2006-12-05 Bristol-Myers Squibb Co. Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
TW200611704A (en) 2004-07-02 2006-04-16 Bristol Myers Squibb Co Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
US7754755B2 (en) 2004-09-23 2010-07-13 Bristol-Myers Squibb Company Inhibitors of 15-lipoxygenase
US7429611B2 (en) 2004-09-23 2008-09-30 Bristol-Myers Squibb Company Indole inhibitors of 15-lipoxygenase
AR051446A1 (es) 2004-09-23 2007-01-17 Bristol Myers Squibb Co Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2)
US7517991B2 (en) 2004-10-12 2009-04-14 Bristol-Myers Squibb Company N-sulfonylpiperidine cannabinoid receptor 1 antagonists
US8143425B2 (en) 2004-10-12 2012-03-27 Bristol-Myers Squibb Company Heterocyclic aromatic compounds useful as growth hormone secretagogues
JP4912314B2 (ja) 2004-10-26 2012-04-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 因子Ｘａ化合物
US7589088B2 (en) 2004-12-29 2009-09-15 Bristol-Myers Squibb Company Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7635699B2 (en) 2004-12-29 2009-12-22 Bristol-Myers Squibb Company Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
WO2006076598A2 (en) 2005-01-12 2006-07-20 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
WO2006076569A2 (en) 2005-01-12 2006-07-20 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
US7368458B2 (en) 2005-01-12 2008-05-06 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
JP5236293B2 (ja) 2005-01-13 2013-07-17 ブリストル−マイヤーズ スクイブ カンパニー Ｘｉａ因子阻害剤としての置換ビアリール化合物
US20060160850A1 (en) 2005-01-18 2006-07-20 Chongqing Sun Bicyclic heterocycles as cannabinoid receptor modulators
AU2006206611A1 (en) 2005-01-19 2006-07-27 Bristol-Myers Squibb Company 2-phenoxy-N- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as P2Y1 receptor inhibitors for the treatment of thromboembolic disorders
EP1846410B1 (en) 2005-02-10 2009-01-21 Bristol-Myers Squibb Company Dihydroquinazolinones as 5ht modulators
EP2527337A1 (en) 2005-04-14 2012-11-28 Bristol-Myers Squibb Company Inhibitors of 11-beta hydroxysteroid dehydrogenase type I
US7521557B2 (en) 2005-05-20 2009-04-21 Bristol-Myers Squibb Company Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
US7632837B2 (en) 2005-06-17 2009-12-15 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid-1 receptor modulators
US7629342B2 (en) 2005-06-17 2009-12-08 Bristol-Myers Squibb Company Azabicyclic heterocycles as cannabinoid receptor modulators
US7317012B2 (en) 2005-06-17 2008-01-08 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoind-1 receptor modulators
US7452892B2 (en) 2005-06-17 2008-11-18 Bristol-Myers Squibb Company Triazolopyrimidine cannabinoid receptor 1 antagonists
TW200726765A (en) 2005-06-17 2007-07-16 Bristol Myers Squibb Co Triazolopyridine cannabinoid receptor 1 antagonists
WO2007002635A2 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
US7714002B2 (en) 2005-06-27 2010-05-11 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
DE602006020871D1 (de) 2005-06-27 2011-05-05 Bristol Myers Squibb Co Lineare harnstoffmimetika-antagonisten des p2y1-rezeptors zur behandlung von thromboseleiden
US7728008B2 (en) 2005-06-27 2010-06-01 Bristol-Myers Squibb Company N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
EP1812411A2 (en) * 2005-07-05 2007-08-01 Teva Pharmaceutical Industries Ltd. Process for preparing valsartan
EP1757290A1 (en) 2005-08-16 2007-02-28 Zentaris GmbH Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors
US7795436B2 (en) 2005-08-24 2010-09-14 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
US7534804B2 (en) 2005-08-24 2009-05-19 Bristol-Myers Squibb Company Benzoxazole inhibitors of 15-lipoxygenase
EP1931199A4 (en) 2005-08-31 2009-07-29 Univ Tennessee Res Foundation COMBATING NURSE DISEASE, BURNS, WOUNDS AND BACKMARK INJURIES WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS
US8618115B2 (en) 2005-10-26 2013-12-31 Bristol-Myers Squibb Company Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them
EP2487154B1 (en) 2005-10-31 2013-10-16 Bristol-Myers Squibb Company Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase IV and methods
US7553836B2 (en) 2006-02-06 2009-06-30 Bristol-Myers Squibb Company Melanin concentrating hormone receptor-1 antagonists
BRPI0708507A2 (pt) * 2006-03-03 2011-05-31 Torrent Pharmaceuticals Ltd Novos antagonistas de receptores de dupla ação (dara) para os receptores at1 eta
WO2007109456A2 (en) * 2006-03-16 2007-09-27 Pharmacopeia, Inc. Substituted biphenyl isoxazole sulfonamides as dual angiotensin endothelin receptor antagonists
WO2007139589A1 (en) 2006-05-26 2007-12-06 Bristol-Myers Squibb Company Sustained release glp-1 receptor modulators
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
HUE032274T2 (en) 2006-07-12 2017-09-28 Univ Tennessee Res Found Substituted acetanilides and methods of their application
US7727978B2 (en) 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
CN101522676A (zh) 2006-10-05 2009-09-02 Cv医药有限公司 用作硬脂酰-CoA脱氢酶抑制剂的双环含氮杂环化合物
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
WO2008091555A2 (en) 2007-01-22 2008-07-31 Gtx, Inc. Nuclear receptor binding agents
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
TW200838501A (en) 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
AR065809A1 (es) 2007-03-22 2009-07-01 Bristol Myers Squibb Co Formulaciones farmaceuticas que contienen un inhibidor sglt2
US20080255161A1 (en) * 2007-04-11 2008-10-16 Dmitry Koltun 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
WO2008130951A1 (en) 2007-04-17 2008-10-30 Bristol-Myers Squibb Company Fused heterocyclic 11-beta-hydroxysteroid dehydrogenase type i inhibitors
PE20090696A1 (es) 2007-04-20 2009-06-20 Bristol Myers Squibb Co Formas cristalinas de saxagliptina y procesos para preparar las mismas
CA2684644A1 (en) 2007-04-23 2008-10-30 Sanofi-Aventis Quinoline-carboxamide derivatives as p2y12 antagonists
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
CN101668759A (zh) 2007-05-04 2010-03-10 百时美施贵宝公司 [6,5]-双环gpr119g蛋白-偶合受体激动剂
ES2388967T3 (es) 2007-05-04 2012-10-22 Bristol-Myers Squibb Company Agonistas [6,6]- y [6,7]-bicíclicos del receptor GPR119 acoplado a la proteína G
TWI406850B (zh) 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
US20090011994A1 (en) 2007-07-06 2009-01-08 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists and methods
TW200904440A (en) 2007-07-17 2009-02-01 Bristol Myers Squibb Co Method for modulating GPR119 G protein-coupled receptor and selected compounds
CN101808995A (zh) 2007-07-27 2010-08-18 百时美施贵宝公司 新颖的葡糖激酶激活剂及其使用方法
EP2200975A1 (en) 2007-09-07 2010-06-30 Theravance, Inc. Dual-acting antihypertensive agents
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
CA2697551C (en) 2007-09-20 2013-03-12 Irm Llc Piperidine derivatives as modulators of gpr119 activity
US8212052B2 (en) 2007-12-11 2012-07-03 Theravance, Inc. Dual-acting benzoimidazole antihypertensive agents
JP5504171B2 (ja) 2007-12-26 2014-05-28 サノフイ Ｐ２ｙ１２アンタゴニストとしてのヘテロサイクリックピラゾール−カルボキサミド
EP2103602A1 (en) 2008-03-17 2009-09-23 AEterna Zentaris GmbH Novel 1,2,4-triazole derivatives and process of manufacturing thereof
JP2011518884A (ja) 2008-04-29 2011-06-30 セラヴァンス， インコーポレーテッド 二重活性抗高血圧剤
CN102099340A (zh) 2008-05-19 2011-06-15 先灵公司 作为因子ixa抑制剂的杂环化合物
PE20091928A1 (es) 2008-05-29 2009-12-31 Bristol Myers Squibb Co Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos
WO2009155448A1 (en) * 2008-06-20 2009-12-23 Ligand Pharmaceuticals Inc. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
TW201006821A (en) 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
US7863309B2 (en) 2008-07-24 2011-01-04 Theravance, Inc. Dual-acting antihypertensive agents
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
CA2755697A1 (en) * 2009-03-17 2010-09-23 Daiichi Sankyo Company, Limited Amide derivative
SG174504A1 (en) 2009-03-27 2011-10-28 Bristol Myers Squibb Co Methods for preventing major adverse cardiovascular events with dpp-iv inhibitors
DK3222277T3 (da) 2009-03-31 2020-05-11 Ligand Pharm Inc Biphenylsulfonamidendothelin- og angiotensin II-receptorantagonist til behandling af glomerulosklerose og IgA-induceret nefropati
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2929347A1 (en) * 2009-05-26 2010-12-02 Milan Bruncko (hetero)aryl substituted sulfonyl-2-(1h-pyrrolo[2,3-b]pyridine-5-oxy)benzamide compounds and their use as apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
SMT202000093T1 (it) 2009-06-16 2020-03-13 Pfizer Forme di dosaggio di apixaban
WO2011005674A1 (en) 2009-07-07 2011-01-13 Theravance, Inc. Dual-acting pyrazole antihypertensive agents
WO2011011232A1 (en) 2009-07-22 2011-01-27 Theravance, Inc. Dual-acting oxazole antihypertensive agents
WO2011014520A2 (en) 2009-07-29 2011-02-03 Irm Llc Compounds and compositions as modulators of gpr119 activity
WO2011017296A1 (en) 2009-08-04 2011-02-10 Schering Corporation 4, 5, 6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
EA201200570A1 (ru) 2009-10-09 2012-11-30 Айрм Ллк Соединения и композиции в качестве модуляторов активности gpr119
ES2689107T3 (es) 2009-11-13 2018-11-08 Astrazeneca Ab Formulaciones de tabletas bicapa
CN104825417A (zh) 2009-11-13 2015-08-12 阿斯利康(瑞典)有限公司 立即释放片剂
MX2012005425A (es) 2009-11-13 2012-06-14 Astrazeneca Uk Ltd Formulaciones de metformina de masa reducida.
CN101921265B (zh) * 2009-11-25 2012-07-04 北京理工大学 联苯酰胺四唑类化合物、合成方法及用途
CN101891735B (zh) * 2009-11-25 2012-07-18 北京理工大学 联苯磺胺异噁唑类化合物、合成方法及用途
US8394858B2 (en) 2009-12-03 2013-03-12 Novartis Ag Cyclohexane derivatives and uses thereof
US8481549B2 (en) 2010-01-19 2013-07-09 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
TWI562775B (en) 2010-03-02 2016-12-21 Lexicon Pharmaceuticals Inc Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
EA201270755A1 (ru) 2010-04-08 2013-03-29 Бристол-Майерс Сквибб Компани Аналоги пиримидинилпиперидинилоксипиридинона в качестве модуляторов рецептора gpr119
WO2011130459A1 (en) 2010-04-14 2011-10-20 Bristol-Myers Squibb Company Novel glucokinase activators and methods of using same
WO2011140160A1 (en) 2010-05-06 2011-11-10 Bristol-Myers Squibb Company Bicyclic heteroaryl compounds as gpr119 modulators
WO2011140161A1 (en) 2010-05-06 2011-11-10 Bristol-Myers Squibb Company Benzofuranyl analogues as gpr119 modulators
US8697739B2 (en) 2010-07-29 2014-04-15 Novartis Ag Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof
EP2431035A1 (en) 2010-09-16 2012-03-21 Æterna Zentaris GmbH Novel Triazole Derivatives with Improved Receptor Activity and Bioavailability Properties as Ghrelin Antagonists of Growth Hormone Secretagogue Receptors
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
SG10201801794WA (en) 2010-10-29 2018-04-27 Abbvie Inc Solid dispersions containing an apoptosis-inducing agent
KR101923364B1 (ko) 2010-11-23 2018-11-30 애브비 인코포레이티드 아폽토시스­유도제의 염 및 결정형
MY165884A (en) 2010-11-23 2018-05-18 Abbvie Ireland Unlimited Co Methods of treatment using selective bcl-2 inhibitors
PH12013501345A1 (en) 2010-12-23 2022-10-24 Purdue Pharma Lp Tamper resistant solid oral dosage forms
IL295438B2 (en) 2011-01-05 2026-05-01 Lexicon Pharmaceuticals Inc Compositions containing and methods for using inhibitors of sodium-glucose cotransporters 1 and 2
GEP201706656B (en) 2011-11-11 2017-04-25 Pfizer 2-thiopyrimidinones
SG11201405477XA (en) 2012-04-06 2014-11-27 Pfizer Diacylglycerol acyltransferase 2 inhibitors
WO2013173198A1 (en) 2012-05-16 2013-11-21 Bristol-Myers Squibb Company Pyrimidinylpiperidinyloxypyridone analogues as gpr119 modulators
AU2013274619B2 (en) 2012-06-11 2017-09-28 Bristol-Myers Squibb Company Phosphoramidic acid prodrugs of 5 - [5 - phenyl- 4 - (pyridin- 2 - ylmethylamino) quinazolin- 2 - yl] pyridine- 3 - sulfonamide
HUE052574T2 (hu) 2012-07-13 2021-05-28 Oncternal Therapeutics Inc Eljárás mellrákok kezelésére szelektív ösztrogén receptor modulátorral (SARM)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
EP2892897A1 (en) 2012-09-05 2015-07-15 Bristol-Myers Squibb Company Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
EP2892896B1 (en) 2012-09-05 2016-06-29 Bristol-Myers Squibb Company Pyrrolone or pyrrolidinone melanin concentrating hormore receptor-1 antagonists
WO2014052619A1 (en) 2012-09-27 2014-04-03 Irm Llc Piperidine derivatives and compositions as modulators of gpr119 activity
EP2925735B1 (en) 2012-11-20 2019-03-13 Lexicon Pharmaceuticals, Inc. Inhibitors of sodium glucose cotransporter 1
US9050345B2 (en) 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
WO2014143609A1 (en) 2013-03-11 2014-09-18 Bristol-Myers Squibb Company Isoquinolines as potassium ion channel inhibitors
EP2970294B1 (en) 2013-03-11 2016-12-28 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
WO2014143607A1 (en) 2013-03-11 2014-09-18 Bristol-Myers Squibb Company Pyrrolopyridazines as potassium ion channel inhibitors
US9242966B2 (en) 2013-03-11 2016-01-26 Bristol-Myers Squibb Company Phthalazines as potassium ion channel inhibitors
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
AU2014233185B2 (en) * 2013-03-15 2018-03-15 University Of Southern California Methods, compounds, and compositions for the treatment of angiotensin-related diseases
JP6348582B2 (ja) 2013-10-09 2018-06-27 ファイザー・インク プロスタグランジンｅｐ３受容体の拮抗薬
WO2015061272A1 (en) 2013-10-22 2015-04-30 Bristol-Myers Squibb Company Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
EP3119757B1 (en) 2014-03-17 2018-05-16 Pfizer Inc Diacylglycerol acyltransferase 2 inhibitors for use in the treatment of metabolic and related disorders
WO2015150995A1 (en) 2014-04-04 2015-10-08 Pfizer Inc. Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors
WO2015160636A1 (en) 2014-04-16 2015-10-22 Merck Sharp & Dohme Corp. Factor ixa inhibitors
ES2864079T3 (es) 2014-05-30 2021-10-13 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
EP3237401B1 (en) 2014-12-22 2019-03-06 Pfizer Inc Antagonists of prostaglandin ep3 receptor
CN104761548B (zh) * 2015-04-27 2017-09-12 梯尔希（南京）药物研发有限公司 一种稳定同位素标记的二苯基磺酰胺类药物的制备方法
MA42035A (fr) 2015-05-05 2018-03-14 Pfizer 2-thiopyrimidinones
US10308615B2 (en) 2015-05-29 2019-06-04 Pfizer Inc. Heterocyclic compounds as inhibitors of Vanin-1 enzyme
ES2832893T3 (es) 2015-06-17 2021-06-11 Pfizer Compuestos tricíclicos y su uso como inhibidores de la fosfodiesterasa
WO2016203335A1 (en) 2015-06-18 2016-12-22 Pfizer Inc. Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors
AU2016305590A1 (en) 2015-08-13 2018-02-15 Pfizer Inc. Bicyclic-fused heteroaryl or aryl compounds
RS61719B1 (sr) 2015-08-27 2021-05-31 Pfizer Biciklična fuzionisana hetaroaril ili aril jedinjenja kao modulatori irak4
WO2017037567A1 (en) 2015-09-03 2017-03-09 Pfizer Inc. Regulators of frataxin
CN105481844A (zh) * 2015-12-08 2016-04-13 梁彦云 一种治疗高血压的药物组合物
JP6503515B2 (ja) 2015-12-29 2019-04-17 ファイザー・インク ケトヘキソキナーゼ阻害薬としての置換３−アザビシクロ［３．１．０］ヘキサン
CN106188115A (zh) * 2016-07-13 2016-12-07 北京理工大学 廉价高效合成2‑二羟硼基‑n‑二甲异噁唑基‑n‑甲氧乙氧甲基苯磺酰胺的新方法
MX2019000536A (es) 2016-07-14 2019-04-01 Pfizer Nuevas pirimidinas carboxamidas como inhibidores de enzima vanina-1.
MA45714A (fr) 2016-07-22 2019-05-29 Bristol Myers Squibb Co Activateurs de glucokinase et leurs procédés d'utilisation
AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
MA46524A (fr) 2016-10-13 2019-08-21 Retrophin Inc Composés de biphényl-sulfonamide destinés au traitement de néphropathies
WO2018162625A1 (en) 2017-03-09 2018-09-13 Truly Translational Sweden Ab Prodrugs of sulfasalazine, pharmaceutical compositions thereof and their use in the treatment of autoimmune disease
DK3630188T3 (da) 2017-05-31 2021-11-15 Amplio Pharma Ab Farmaceutisk sammensætning omfattende en kombination af methotrexat og novobiocin og anvendelse af sammensætningen til behandling
EP3489222A1 (en) 2017-11-23 2019-05-29 medac Gesellschaft für klinische Spezialpräparate mbH Sulfasalazine salts, production processes and uses
FI3488868T3 (fi) 2017-11-23 2023-10-20 Medac Ges Fuer Klinische Spezialpraeparate Mbh Suun kautta annettava sulfasalatsiinia ja/tai sulfasalatsiinin orgaanista suolaa sisältävä farmaseuttinen koostumus, valmistusmenetelmä ja käyttö
CN111518770B (zh) 2017-12-19 2023-01-06 北京吉源生物科技有限公司 一种表达glp1和fgf21的干细胞及其用途
WO2019133445A1 (en) 2017-12-28 2019-07-04 Inception Ibd, Inc. Aminothiazoles as inhibitors of vanin-1
WO2020016335A1 (en) 2018-07-19 2020-01-23 Astrazeneca Ab Methods of treating hfpef employing dapagliflozin and compositions comprising the same
BR112021003039A2 (pt) 2018-08-31 2021-05-18 Pfizer Inc. combinações para o tratamento de nash/nafld e doenças relacionadas
AU2019346497A1 (en) 2018-09-26 2021-04-08 Lexicon Pharmaceuticals, Inc. Crystalline forms of n-(1 -((2-(dimethylamino)ethyl)amino)-2-m ethyl-1 -oopropan-2-yl)-4-(4-(2-methyl-5- (2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)benzyl) phenl)butanamide and methods of their synthesis
MA53817A (fr) 2018-10-04 2021-08-11 Travere Therapeutics Inc Composés biphényl-sulfonamide destinés au traitement de maladies du collagène de type iv
WO2020102575A1 (en) 2018-11-16 2020-05-22 Inception Ibd, Inc. Heterocyclic aminothiazoles and uses thereof
US12611401B2 (en) 2019-05-20 2026-04-28 Pfizer Inc. Combinations comprising benzodioxol as GLP-1R agonists for use in the treatment of NASH/NAFLD and related diseases
CA3144848C (en) 2019-06-28 2023-11-21 Pfizer Inc. 5-(thiophen-2-yl)-1h-tetrazole derivatives as bckdk inhibitors useful for treating various diseases
TW202115086A (zh) 2019-06-28 2021-04-16 美商輝瑞大藥廠 Bckdk抑制劑
TWI771766B (zh) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
PE20231066A1 (es) 2020-02-07 2023-07-17 Gasherbrum Bio Inc Agonistas heterociclicos de glp-1
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
EP4143183B1 (en) 2020-04-29 2025-10-22 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
PE20231215A1 (es) 2020-06-09 2023-08-17 Pfizer Compuestos espiro como antagonistas del receptor de melanocortina 4 y usos de los mismos
PT4188389T (pt) 2020-07-27 2025-10-07 Astrazeneca Ab Dapagliflozina para utilização em métodos de tratamento de doença renal crónica
AU2021202643B2 (en) 2020-07-27 2023-02-02 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin
WO2022266370A1 (en) 2021-06-17 2022-12-22 Aria Pharmaceuticals, Inc. Sparsentan for treating idiopathic pulmonary fibrosis
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators
CA3222721A1 (en) * 2021-07-09 2023-01-12 Nadia Nasser PETERSEN New selective angiotensin ii compounds
AU2022334402A1 (en) * 2021-08-26 2024-02-22 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Aromatic ring-containing biological antagonist, and preparation method therefor and use thereof
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
JP7735563B2 (ja) * 2021-10-21 2025-09-08 ニコヤ セラピューティクス（シャンハイ）カンパニー リミテッド 二重アンタゴニスト及びその使用
AU2022403203B2 (en) 2021-12-01 2025-09-25 Pfizer Inc. 3-phenyl-1-benzothiophene-2-carboxylic acid derivatives as branched-chain alpha keto acid dehydrogenase kinase inhibitors for the treatment of diabetes, kidney diseases, nash and heart failure
CA3241470A1 (en) 2021-12-06 2023-06-15 Pfizer Inc. Melanocortin 4 receptor antagonists and uses thereof
CN118510504A (zh) 2022-01-26 2024-08-16 阿斯利康(瑞典)有限公司 用于在治疗糖尿病前期或降低发展2型糖尿病的风险中使用的达格列净
JP2025509281A (ja) 2022-03-09 2025-04-11 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環式ｇｌｐ－１アゴニスト
EP4508047A1 (en) 2022-04-14 2025-02-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2023224963A1 (en) * 2022-05-16 2023-11-23 Aria Pharmaceuticals, Inc. Dual-acting angiotensin and endothelin receptor antagonists
IL319486A (en) 2022-10-07 2025-05-01 Pfizer HSD17B13 Inhibitors and/or Retarders
US20240182468A1 (en) 2022-10-18 2024-06-06 Pfizer Inc. Compounds for the activation of ampk
CN120129681A (zh) 2022-10-18 2025-06-10 辉瑞大药厂 含Patatin样磷脂酶结构域的蛋白3（PNPLA3）调节剂
CN115745983A (zh) * 2022-11-23 2023-03-07 深圳信立泰药业股份有限公司 一种血管紧张肽和内皮肽受体拮抗剂及其应用
KR20250157491A (ko) 2022-12-15 2025-11-04 가셔브룸 바이오, 인크. Glp-1 효능제 활성을 갖는 화합물의 염 및 고체 형태
JP2025541231A (ja) 2022-12-16 2025-12-18 ファイザー・インク ３－フルオロ－４－ヒドロキシベンズアミド含有阻害剤および／または分解剤ならびにそれらの使用
CN120752231A (zh) * 2023-02-24 2025-10-03 江苏豪森药业集团有限公司 含芳环类衍生物拮抗剂的盐、其制备方法和应用
EP4695226A1 (en) 2023-04-14 2026-02-18 Pfizer Inc. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof
CN116731004B (zh) * 2023-06-08 2025-11-25 李能刚 作为血管紧张素和内皮素受体双重拮抗剂的联苯磺酰胺
WO2025099566A1 (en) 2023-11-08 2025-05-15 Pfizer Inc. A crystalline form of 6-fluoro-3-(2,4,5-trifluoro-3-methoxyphenyl)-1-benzothiophene-2-carboxylic acid
IT202400000246A1 (it) * 2024-01-09 2025-07-09 Procos Spa Processo per la preparazione di sparsentan
TW202539633A (zh) 2024-02-01 2025-10-16 美商輝瑞股份有限公司 葡萄糖依賴性促胰島素多肽受體拮抗劑及其用途
TW202600540A (zh) 2024-04-22 2026-01-01 美商輝瑞大藥廠 葡萄糖依賴性促胰島素多肽受體拮抗劑及其用途
WO2026013531A1 (en) 2024-07-10 2026-01-15 Pfizer Inc. Spiro[2.5]octane compounds
WO2026033382A1 (en) 2024-08-07 2026-02-12 Pfizer Inc. Heterocyclic glp-1r modulators
WO2026042018A1 (en) 2024-08-21 2026-02-26 Pfizer Inc. 4-{4-[(1-{[4-(propan-2-yl)phenyl]carbamoyl)-d-prolyl)amino]cyclohexyl}benzoic acid derivatives as gipr antagonists for the treatment of diabetes
WO2026078617A1 (en) 2024-10-11 2026-04-16 Pfizer Inc. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof
WO2026078674A1 (en) 2024-10-13 2026-04-16 Pfizer Inc. Heterocyclic derivatives as glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof
WO2026078670A1 (en) 2024-10-13 2026-04-16 Pfizer Inc. Heterocyclic derivatives as glucose-dependent insulinotropic polypeptide receptor antagonists
WO2026078672A1 (en) 2024-10-13 2026-04-16 Pfizer Inc. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof
WO2026078673A1 (en) 2024-10-13 2026-04-16 Pfizer Inc. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof
WO2026078671A1 (en) 2024-10-13 2026-04-16 Pfizer Inc. Heterocyclic compounds as glucose-dependent insulinotropic polypeptide receptor antagonists
WO2026088071A1 (en) 2024-10-23 2026-04-30 Pfizer Inc. Substituted fused heteroaryl lactam compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1724657A1 (ru) 1990-02-26 1992-04-07 Научно-Производственный Кооператив "Охрана Природы" Способ приготовлени сапропелевого удобрени
RU2041866C1 (ru) 1994-01-20 1995-08-20 Акционерное предприятие "Сапропель-Неро" Способ добычи и получения сапропелевого удобрения

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
CA2020073A1 (en) * 1989-07-03 1991-01-04 Eric E. Allen Substituted quinazolinones as angiotensin ii antagonists
US5240928A (en) * 1989-07-03 1993-08-31 Merck & Co., Inc. Substituted quinazolinones as angiotensin II antagonists
JPH05504969A (ja) 1990-02-13 1993-07-29 メルク・エンド・カムパニー・インコーポレーテツド 置換ベンジル要素を含有するアンギオテンシン２アンタゴニスト類
DE122010000024I1 (de) * 1990-02-19 2010-07-08 Novartis Ag Acylverbindungen
FR2681067B1 (fr) 1991-09-10 1993-12-17 Elf Sanofi Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
IE912956A1 (en) * 1990-09-10 1992-03-11 Abbott Lab Angiotensin ii receptor antagonists
US5250548A (en) * 1990-09-10 1993-10-05 Abbott Laboratories Angiotensin II receptor antagonists
CA2057089A1 (en) 1990-12-07 1992-06-08 Eric E. Allen Substituted pyrazolopyrimidines and imidazopyridazines as angiotensin ii antagonists
TW274551B (lt) 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
CA2079982A1 (en) * 1991-10-07 1993-04-08 Stephen E. De Laszlo Substituted pyrazino (2,3-d)-pyrimidinones as angiotensin ii antagonists
US5674883A (en) * 1992-02-07 1997-10-07 Roussel Uclaf Derivatives of pyridone, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
WO1993017681A1 (en) 1992-03-02 1993-09-16 Abbott Laboratories Angiotensin ii receptor antagonists
GB2264710A (en) * 1992-03-04 1993-09-08 Merck & Co Inc Quinoline and azaquinoline angiotensin ii antagonists incorporating a substituted biphenyl element
DE4208304A1 (de) * 1992-03-16 1993-09-23 Merck Patent Gmbh 2-oxochinolinderivate
US5514696A (en) * 1992-05-06 1996-05-07 Bristol-Myers Squibb Co. Phenyl sulfonamide endothelin antagonists
US5256658A (en) 1993-01-15 1993-10-26 Ortho Pharmaceutical Corporation Angiotensin II inhibitors
DE4300912A1 (de) 1993-01-15 1994-07-21 Merck Patent Gmbh Chinazolinderivate
ES2126061T3 (es) 1993-03-24 1999-03-16 American Home Prod Piridopirimidinas substituidas como antihipertensores.
DE4320432A1 (de) 1993-06-21 1994-12-22 Bayer Ag Substituierte Mono- und Bipyridylmethylderivate
ZA945190B (en) 1993-07-30 1995-02-24 Kotobuki Seiyaku Co Ltd Carboxymethylidenecycloheptimidazole derivatives method or manufacturing the same and therapeutic agents containing these compounds
US5674879A (en) 1993-09-24 1997-10-07 G.D. Searle & Co. Compositions including and methods of using conformationally restricted angiotensin II antagonist
US5438136A (en) 1993-11-02 1995-08-01 Merck & Co., Inc. Benzo-fused macrocycles promote release of growth hormone
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
FR2725987B1 (fr) 1994-10-19 1997-01-10 Sanofi Sa Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
CA2168154A1 (en) * 1995-02-06 1996-08-07 Natesan Murugesan Substituted biphenyl sulfonamide endothelin antagonists
NZ306734A (lt) * 1995-04-04 2000-01-28 Texas Biotechnology Corp
GB9512697D0 (en) * 1995-06-22 1995-08-23 Zeneca Ltd Heterocyclic compounds
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
PL328571A1 (en) 1996-02-20 1999-02-01 Bristol Myers Squibb Co Methods of obtaining biphenylisoxazol sulphonamides
AU2074297A (en) * 1996-03-12 1997-10-01 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
IT1283620B1 (it) 1996-04-19 1998-04-22 Luso Farmaco Inst "pirimidin-4-oni n-3 sostituiti ad attivita' aii antagonista"
JPH09291078A (ja) 1996-04-25 1997-11-11 Kyorin Pharmaceut Co Ltd オルトメトキシフェニルピペラジニルアルコキシアリール基を有する新規イミダゾール誘導体及びその製造法
TW536540B (en) 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
US5846985A (en) * 1997-03-05 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
PT1094816E (pt) * 1998-07-06 2009-03-10 Bristol Myers Squibb Co Sulfonamidas bifenílicas duplamente antagonistas receptores de angiotensina e endotelina

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1724657A1 (ru) 1990-02-26 1992-04-07 Научно-Производственный Кооператив "Охрана Природы" Способ приготовлени сапропелевого удобрени
RU2041866C1 (ru) 1994-01-20 1995-08-20 Акционерное предприятие "Сапропель-Неро" Способ добычи и получения сапропелевого удобрения

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
L. KATKEVIČIUS, A.CIŪNYS, E.BAKŠIENĖ: "Ežerų sapropelis žemės ūkiui", pages: 30 - 50

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT6043B (lt) 2012-08-27 2014-06-25 Uab "Mibarsas" Organinės trąšos sapropelio pagrindu ir jų gamybos būdas
LT7101B (lt) 2024-01-16 2024-10-25 Steponavičius Petras Organinės trąšos sapropelio pagrindu ir jų gamybos būdas, panaudojant susmulkintus šiaudus, aukštapelkines durpes ir hidrogelį

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EP1094816A4 (en) 2001-12-19
WO2000001389A1 (en) 2000-01-13
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GEP20033114B (en) 2003-11-25
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SK18822000A3 (sk) 2001-12-03

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