LTC2207786I2 - - Google Patents

Info

Publication number: LTC2207786I2
Authority: LT; Lithuania

Application number

LTPA2023538C

Original Assignee

Otsuka Pharmaceutical Co., Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-16

Filing date

2023-12-29

Publication date

2025-09-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40251685&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LTC2207786(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2023-12-29 Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.

2024-02-26 Publication of LTPA2023538I1 publication Critical patent/LTPA2023538I1/lt

2025-09-10 Publication of LTC2207786I2 publication Critical patent/LTC2207786I2/lt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

LTPA2023538C 2007-10-16 2023-12-29 LTC2207786I2 (lt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US98039707P	2007-10-16	2007-10-16
PCT/US2008/080163 WO2009052287A1 (en)	2007-10-16	2008-10-16	2 ' -flu0r0-2 ' -deoxytetrahydrouridines as cytidine deaminase inhibitors

Publications (2)

Publication Number	Publication Date
LTPA2023538I1 LTPA2023538I1 (lt)	2024-02-26
LTC2207786I2 true LTC2207786I2 (lt)	2025-09-10

Family

ID=40251685

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LTPA2023539C LTPA2023539I1 (lt)	2007-10-16	2023-12-29
LTPA2023538C LTC2207786I2 (lt)	2007-10-16	2023-12-29

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
LTPA2023539C LTPA2023539I1 (lt)	2007-10-16	2023-12-29

Country Status (40)

Country	Link
US (4)	US8268800B2 (lt)
EP (2)	EP2207786B1 (lt)
JP (2)	JP5496899B2 (lt)
KR (1)	KR101543049B1 (lt)
CN (1)	CN101827856B (lt)
AT (1)	ATE548374T1 (lt)
BR (1)	BRPI0818672B8 (lt)
CA (1)	CA2702274C (lt)
CO (1)	CO6270330A2 (lt)
CR (1)	CR11427A (lt)
CY (3)	CY1112781T1 (lt)
DK (1)	DK2207786T3 (lt)
EA (1)	EA018757B1 (lt)
EC (1)	ECSP10010095A (lt)
ES (2)	ES2384011T3 (lt)
FI (2)	FIC20230039I1 (lt)
FR (2)	FR23C1051I2 (lt)
GT (1)	GT201000088A (lt)
HR (1)	HRP20120419T1 (lt)
HU (2)	HUS2300045I1 (lt)
IL (1)	IL204732A (lt)
JO (1)	JO2778B1 (lt)
LT (2)	LTPA2023539I1 (lt)
LU (2)	LUC00326I9 (lt)
ME (1)	ME00997B (lt)
MX (1)	MX2010004109A (lt)
MY (1)	MY147970A (lt)
NI (1)	NI201000055A (lt)
NL (2)	NL301257I2 (lt)
NO (2)	NO2023047I1 (lt)
NZ (1)	NZ584229A (lt)
PL (1)	PL2207786T3 (lt)
PT (1)	PT2207786E (lt)
RS (1)	RS52323B (lt)
SA (1)	SA08290661B1 (lt)
SI (1)	SI2207786T1 (lt)
TW (1)	TWI445539B (lt)
UA (1)	UA99476C2 (lt)
WO (1)	WO2009052287A1 (lt)
ZA (1)	ZA201002178B (lt)

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PL3290428T3 (pl)	2010-03-31	2022-02-07	Gilead Pharmasset Llc	Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
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MY172166A (en)	2013-01-31	2019-11-15	Gilead Pharmasset Llc	Combination formulation of two antiviral compounds
EP3650014B1 (en)	2013-08-27	2021-10-06	Gilead Pharmasset LLC	Combination formulation of two antiviral compounds
NZ718607A (en)	2013-10-29	2019-10-25	Otsuka Pharma Co Ltd	Synthetic route to 2’-deoxy-2’,2’-difluorotetrahydrouridines
CA2946538A1 (en)	2014-04-04	2015-10-08	Del Mar Pharmaceuticals	Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
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MX393043B (es) *	2015-12-03	2025-03-24	Epidestiny Inc	Composiciones que contienen decitabina, 5azacitidina y tetrahidrouridina y sus usos
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PE20210367A1 (es)	2018-02-02	2021-02-26	Maverix Oncology Inc	Conjugados de farmacos de molecula pequena de monofosfato de gemcitabina
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US11224610B2 (en) *	2018-09-19	2022-01-18	Otsuka Pharmaceutical Co., Ltd.	Low dose combination CDA substrate drug/cedazuridine with extended administration
US12448624B2 (en)	2018-10-19	2025-10-21	Interoligo Corporation	Modified nucleic acid having improved treatment efficacy, and anticancer pharmaceutical composition containing same
CN112888700B (zh) *	2018-10-19	2025-03-04	因特欧力多公司	具有改善治疗功效的修饰核酸和含有其的抗癌药物组合物
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EP2417146B1 (en)	2009-04-06	2016-07-13	Otsuka Pharmaceutical Co., Ltd.	(2'-deoxy-ribofuranosyl)-1,3,4,7-tetrahydro-(1,3)diazepin-2-one derivatives for treating cancer

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Also Published As

Publication number	Publication date
IL204732A0 (en)	2010-11-30
HUS2300045I1 (hu)	2024-01-28
TWI445539B (zh)	2014-07-21
LUC00326I9 (lt)	2026-02-25
CY2023029I1 (el)	2024-02-16
KR101543049B1 (ko)	2015-08-07
EA201000642A1 (ru)	2010-10-29
CO6270330A2 (es)	2011-04-20
DK2207786T3 (da)	2012-06-18
KR20100091978A (ko)	2010-08-19
US20090137521A1 (en)	2009-05-28
JP2014177455A (ja)	2014-09-25
JP5496899B2 (ja)	2014-05-21
PT2207786E (pt)	2012-05-28
CY1112781T1 (el)	2016-02-10
AU2008312435A1 (en)	2009-04-23
MX2010004109A (es)	2010-08-10
NL301256I1 (lt)	2024-01-03
NO2023047I1 (no)	2023-12-21
ECSP10010095A (es)	2010-07-30
US20140186335A1 (en)	2014-07-03
ATE548374T1 (de)	2012-03-15
FR23C1051I2 (fr)	2025-02-07
AU2008312435B2 (en)	2014-04-17
CR11427A (es)	2010-08-16
EP2207786A1 (en)	2010-07-21
US8951987B2 (en)	2015-02-10
CN101827856A (zh)	2010-09-08
NL301257I2 (nl)	2025-11-06
SA08290661B1 (ar)	2012-06-10
US20120289475A1 (en)	2012-11-15
WO2009052287A1 (en)	2009-04-23
NZ584229A (en)	2012-06-29
FR23C1051I1 (fr)	2024-01-26
ES2616566T3 (es)	2017-06-13
NO2023048I1 (en)	2023-12-21
ZA201002178B (en)	2011-05-25
EP2447272A1 (en)	2012-05-02
RS52323B (sr)	2012-12-31
LTPA2023539I1 (lt)	2024-02-26
FIC20230039I1 (fi)	2023-12-22
UA99476C2 (en)	2012-08-27
TW200924786A (en)	2009-06-16
PL2207786T3 (pl)	2012-09-28
LUC00326I2 (lt)	2026-02-02
EP2447272B1 (en)	2017-02-01
CY2023028I1 (el)	2024-02-16
NI201000055A (es)	2010-08-13
US20150210730A1 (en)	2015-07-30
US8268800B2 (en)	2012-09-18
SI2207786T1 (sl)	2012-10-30
GT201000088A (es)	2012-03-13
CA2702274C (en)	2015-12-29
HK1146410A1 (en)	2011-06-03
LTPA2023538I1 (lt)	2024-02-26
JP5859588B2 (ja)	2016-02-10
BRPI0818672B8 (pt)	2021-05-25
US9567363B2 (en)	2017-02-14
JO2778B1 (en)	2014-03-15
HRP20120419T1 (hr)	2012-07-31
LUC00327I2 (lt)	2026-02-02
BRPI0818672A2 (pt)	2015-04-14
BRPI0818672B1 (pt)	2020-10-20
EA018757B1 (ru)	2013-10-30
ME00997B (me)	2012-10-20
CN101827856B (zh)	2013-02-06
EP2207786B1 (en)	2012-03-07
MY147970A (en)	2013-02-28
AU2008312435A8 (en)	2014-07-24
FIC20230040I1 (fi)	2023-12-22
ES2384011T3 (es)	2012-06-28
US8618075B2 (en)	2013-12-31
IL204732A (en)	2013-07-31
FR23C1052I2 (fr)	2025-02-07
JP2011500713A (ja)	2011-01-06
FR23C1052I1 (fr)	2024-01-26
CA2702274A1 (en)	2009-04-23
HUS2300044I1 (hu)	2024-01-28
NL301256I2 (nl)	2024-01-11

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