LTC2805723I2 - Kladribino režimas, skirtas išsėtinei sklerozei gydyti - Google Patents

Kladribino režimas, skirtas išsėtinei sklerozei gydyti

Info

Publication number
LTC2805723I2
LTC2805723I2 LTPA2018503C LTPA2018503C LTC2805723I2 LT C2805723 I2 LTC2805723 I2 LT C2805723I2 LT PA2018503 C LTPA2018503 C LT PA2018503C LT PA2018503 C LTPA2018503 C LT PA2018503C LT C2805723 I2 LTC2805723 I2 LT C2805723I2
Authority
LT
Lithuania
Prior art keywords
cladribin
regime
treatment
multiple sclerosis
sclerosis
Prior art date
Application number
LTPA2018503C
Other languages
English (en)
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36227798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LTC2805723(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of LTPA2018503I1 publication Critical patent/LTPA2018503I1/lt
Publication of LTC2805723I2 publication Critical patent/LTC2805723I2/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/215IFN-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
LTPA2018503C 2004-12-22 2018-02-20 Kladribino režimas, skirtas išsėtinei sklerozei gydyti LTC2805723I2 (lt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63866904P 2004-12-22 2004-12-22
EP04106909 2004-12-22
EP05823474A EP1827461B1 (en) 2004-12-22 2005-12-20 Cladribine regimen for treating multiple sclerosis
EP14001970.4A EP2805723B1 (en) 2004-12-22 2005-12-20 Cladribine regimen for treating multiple sclerosis
EP10182676.6A EP2263678B1 (en) 2004-12-22 2005-12-20 Cladribine regimen for treating early secondary progressive Multiple Sclerosis

Publications (2)

Publication Number Publication Date
LTPA2018503I1 LTPA2018503I1 (lt) 2018-03-12
LTC2805723I2 true LTC2805723I2 (lt) 2022-04-25

Family

ID=36227798

Family Applications (3)

Application Number Title Priority Date Filing Date
LTEP22166610.0T LT4070800T (lt) 2004-12-22 2005-12-20 Kladribino gydymo schema, skirta išsėtinei sklerozei gydyti
LTEP18151634.5T LT3332789T (lt) 2004-12-22 2005-12-20 Kladribino režimas, skirtas išsėtinės sklerozės gydymui
LTPA2018503C LTC2805723I2 (lt) 2004-12-22 2018-02-20 Kladribino režimas, skirtas išsėtinei sklerozei gydyti

Family Applications Before (2)

Application Number Title Priority Date Filing Date
LTEP22166610.0T LT4070800T (lt) 2004-12-22 2005-12-20 Kladribino gydymo schema, skirta išsėtinei sklerozei gydyti
LTEP18151634.5T LT3332789T (lt) 2004-12-22 2005-12-20 Kladribino režimas, skirtas išsėtinės sklerozės gydymui

Country Status (25)

Country Link
US (2) US7713947B2 (lt)
EP (7) EP2275110B1 (lt)
JP (7) JP5795456B2 (lt)
KR (1) KR20070091662A (lt)
AR (1) AR052830A1 (lt)
AU (2) AU2005318190B2 (lt)
BR (1) BRPI0517132B8 (lt)
CA (2) CA2588966C (lt)
CY (3) CY1112614T1 (lt)
DK (3) DK2805723T3 (lt)
EA (1) EA015799B1 (lt)
ES (2) ES2921858T3 (lt)
FI (1) FI4070800T3 (lt)
FR (1) FR18C1008I2 (lt)
HR (1) HRP20120228T1 (lt)
HU (3) HUE070333T2 (lt)
IL (2) IL183930A0 (lt)
LT (3) LT4070800T (lt)
LU (1) LUC00064I2 (lt)
MX (1) MX2007007610A (lt)
NO (1) NO20073813L (lt)
PL (4) PL2805723T3 (lt)
SG (1) SG160391A1 (lt)
SI (3) SI3332789T1 (lt)
WO (1) WO2006067141A1 (lt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2805723T3 (da) 2004-12-22 2018-01-29 Merck Serono Sa Cladribin-regime til behandling af multipel sclerose
MX2008014971A (es) 2006-05-24 2008-12-05 Serono Lab Regimen de cladribine para tratar esclerosis multiple.
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
WO2011117267A1 (en) 2010-03-24 2011-09-29 Merck Serono Sa Cladribine treatment of multiple sclerosis in patient groups defined by genotype
EP2428201A1 (en) 2010-09-08 2012-03-14 Merck Serono S.A. Oral administration of nucleoside monophosphates
WO2012097867A1 (en) 2011-01-18 2012-07-26 Synthon Bv Cladribine particles and pharmaceutical compositions comprising them
GB201401465D0 (en) 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
GB2564717A (en) * 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
CN111356460A (zh) * 2017-11-24 2020-06-30 默克专利股份公司 用于治疗进展型形式的多发性硬化症的克拉屈滨疗法
CA3194812A1 (en) 2020-09-10 2022-03-17 Merck Patent Gmbh Novel treatment regimen for the treatment of autoimmune disorders
GB2601786A (en) * 2020-12-10 2022-06-15 Chord Therapeutics S A R L Use of cladribine for treating immune brain disease

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1269659A (en) 1984-08-06 1990-05-29 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
US4964848A (en) * 1988-06-27 1990-10-23 Bloom Philip M Treatment of multiple sclerosis with lymphocytapheresis and chemo-immunosuppression
US5208327A (en) 1991-12-18 1993-05-04 Ortho Pharmaceutical Corporation Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine
US5641757A (en) 1994-12-21 1997-06-24 Ortho Pharmaceutical Corporation Stable 2-chloro-2'-deoxyadenosine formulations
PT801571E (pt) 1994-12-22 2002-12-31 Ortho Pharma Corp Formulacoes soluveis de 2-cloro-2'-desoxiadenosina
US6194395B1 (en) 1999-02-25 2001-02-27 Orthro-Mcneil Pharmaceutical, Inc. Cyclodextrin cladribine formulations
WO2000064918A1 (en) 1999-04-28 2000-11-02 Sterrenbeld Biotechnologie North America, Inc. METHOD FOR THE PRODUCTION OF 2-CHLORO-2'-DEOXYADENOSINE (CLADRIBINE) AND ITS 3,5-DI-O-p-TOLUOYL DERIVATIVE
DE10237146A1 (de) * 2002-08-13 2004-03-04 Medac Gesellschaft für klinische Spezialpräparate mbH Verwendung von Treosulfan und Derivaten davon zur Behandlung der Multiplen Sklerose
WO2004028462A2 (en) 2002-09-25 2004-04-08 Brigham Young University, Technology Transfer Office Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosine
GB2394658A (en) * 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
WO2004075903A1 (en) * 2003-02-25 2004-09-10 Applied Research Systems Ars Holding N.V. Combined use of ribavirin and interferon beta in demyelinating diseases
KR101129816B1 (ko) 2003-03-28 2012-03-26 아레스 트레이딩 에스.아. 클라드리빈의 경구용 제형
KR20060011943A (ko) 2003-03-28 2006-02-06 아이박스 코포레이션 향상된 경구 및 경점막 수송용 클라드리빈 제형
DK2805723T3 (da) 2004-12-22 2018-01-29 Merck Serono Sa Cladribin-regime til behandling af multipel sclerose
MX2008014971A (es) * 2006-05-24 2008-12-05 Serono Lab Regimen de cladribine para tratar esclerosis multiple.

Also Published As

Publication number Publication date
HUE059133T2 (hu) 2022-10-28
HUE070333T2 (hu) 2025-05-28
JP5795456B2 (ja) 2015-10-14
JP2008524313A (ja) 2008-07-10
FR18C1008I1 (lt) 2018-03-30
PL4070800T3 (pl) 2025-03-10
JP6092945B2 (ja) 2017-03-08
EP4070800A1 (en) 2022-10-12
PL1827461T3 (pl) 2012-07-31
KR20070091662A (ko) 2007-09-11
EP3332789B1 (en) 2022-04-06
BRPI0517132B1 (pt) 2020-02-18
EP2263678B1 (en) 2014-06-11
DK2805723T3 (da) 2018-01-29
EP2263678A2 (en) 2010-12-22
EP2805723B1 (en) 2018-01-17
AU2005318190B2 (en) 2010-11-25
HRP20120228T1 (hr) 2012-04-30
LTPA2018503I1 (lt) 2018-03-12
SI3332789T1 (sl) 2022-08-31
EP4523753A2 (en) 2025-03-19
BRPI0517132A (pt) 2008-09-30
IL212421A0 (en) 2011-06-30
EP2275110A3 (en) 2011-04-27
AU2005318190A1 (en) 2006-06-29
EP4070800B1 (en) 2024-10-16
JP5908863B2 (ja) 2016-04-26
CY2018006I2 (el) 2018-06-27
JP2018165271A (ja) 2018-10-25
CA3087419C (en) 2023-03-07
JP2017101061A (ja) 2017-06-08
EP2275110A2 (en) 2011-01-19
CA2588966A1 (en) 2006-06-29
AU2011200768B2 (en) 2012-09-13
JP6430554B2 (ja) 2018-11-28
CY1119790T1 (el) 2018-06-27
LUC00064I1 (lt) 2018-02-14
CA2588966C (en) 2020-07-21
FR18C1008I2 (fr) 2019-03-01
AR052830A1 (es) 2007-04-04
EP1827461A1 (en) 2007-09-05
LT4070800T (lt) 2025-01-10
JP2016138128A (ja) 2016-08-04
ES3007339T3 (en) 2025-03-19
SG160391A1 (en) 2010-04-29
US7713947B2 (en) 2010-05-11
SI4070800T1 (sl) 2025-03-31
LUC00064I2 (lt) 2018-03-28
AU2011200768A1 (en) 2011-03-17
NO20073813L (no) 2007-09-21
JP2015180685A (ja) 2015-10-15
MX2007007610A (es) 2007-08-03
JP2020193206A (ja) 2020-12-03
EA015799B1 (ru) 2011-12-30
DK3332789T3 (da) 2022-07-11
DK4070800T3 (da) 2025-01-02
PL3332789T3 (pl) 2022-08-22
US20090081163A1 (en) 2009-03-26
IL183930A0 (en) 2007-10-31
CY1112614T1 (el) 2016-02-10
ES2921858T3 (es) 2022-09-01
EP3332789A1 (en) 2018-06-13
US8377903B2 (en) 2013-02-19
EP2805723A1 (en) 2014-11-26
BRPI0517132B8 (pt) 2021-05-25
PL2805723T3 (pl) 2018-04-30
CY2018006I1 (el) 2018-06-27
JP6290962B2 (ja) 2018-03-07
EP2263678A3 (en) 2011-04-27
EP1827461B1 (en) 2012-02-29
FI4070800T3 (fi) 2025-01-14
LT3332789T (lt) 2022-07-25
US20100203017A1 (en) 2010-08-12
EP4523753A3 (en) 2025-05-28
CA3087419A1 (en) 2006-06-29
WO2006067141A1 (en) 2006-06-29
JP2013216664A (ja) 2013-10-24
SI2805723T1 (en) 2018-02-28
EP2275110B1 (en) 2013-07-10
HUS1800009I1 (hu) 2018-05-02
EA200701221A1 (ru) 2008-02-28
IL212421A (en) 2014-01-30

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