CY2018006I2 - Θεραπευτικο σχημα κλαδριβινης για την θεραπευτικη αντιμετωπιση της σκληρυνσης κατα πλακας - Google Patents

Θεραπευτικο σχημα κλαδριβινης για την θεραπευτικη αντιμετωπιση της σκληρυνσης κατα πλακας

Info

Publication number
CY2018006I2
CY2018006I2 CY2018006C CY2018006C CY2018006I2 CY 2018006 I2 CY2018006 I2 CY 2018006I2 CY 2018006 C CY2018006 C CY 2018006C CY 2018006 C CY2018006 C CY 2018006C CY 2018006 I2 CY2018006 I2 CY 2018006I2
Authority
CY
Cyprus
Prior art keywords
therapeutic
sticherone
cladrivine
plaque
formulation
Prior art date
Application number
CY2018006C
Other languages
English (en)
Other versions
CY2018006I1 (el
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36227798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2018006(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of CY2018006I1 publication Critical patent/CY2018006I1/el
Publication of CY2018006I2 publication Critical patent/CY2018006I2/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CY2018006C 2004-12-22 2018-02-28 Θεραπευτικο σχημα κλαδριβινης για την θεραπευτικη αντιμετωπιση της σκληρυνσης κατα πλακας CY2018006I2 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63866904P 2004-12-22 2004-12-22
EP04106909 2004-12-22
EP14001970.4A EP2805723B1 (en) 2004-12-22 2005-12-20 Cladribine regimen for treating multiple sclerosis
EP05823474A EP1827461B1 (en) 2004-12-22 2005-12-20 Cladribine regimen for treating multiple sclerosis
EP10182676.6A EP2263678B1 (en) 2004-12-22 2005-12-20 Cladribine regimen for treating early secondary progressive Multiple Sclerosis

Publications (2)

Publication Number Publication Date
CY2018006I1 CY2018006I1 (el) 2018-06-27
CY2018006I2 true CY2018006I2 (el) 2018-06-27

Family

ID=36227798

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20121100358T CY1112614T1 (el) 2004-12-22 2012-04-11 Αγωγη με κλαδριβινη για τη θεραπεια πολλαπλης σκληρυνσης
CY20181100065T CY1119790T1 (el) 2004-12-22 2018-01-18 Θεραπευτικο σχημα κλαδριβινης για την θεραπευτικη αντιμετωπιση της σκληρυνσης κατα πλακας
CY2018006C CY2018006I2 (el) 2004-12-22 2018-02-28 Θεραπευτικο σχημα κλαδριβινης για την θεραπευτικη αντιμετωπιση της σκληρυνσης κατα πλακας

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CY20121100358T CY1112614T1 (el) 2004-12-22 2012-04-11 Αγωγη με κλαδριβινη για τη θεραπεια πολλαπλης σκληρυνσης
CY20181100065T CY1119790T1 (el) 2004-12-22 2018-01-18 Θεραπευτικο σχημα κλαδριβινης για την θεραπευτικη αντιμετωπιση της σκληρυνσης κατα πλακας

Country Status (25)

Country Link
US (2) US7713947B2 (el)
EP (7) EP3332789B1 (el)
JP (7) JP5795456B2 (el)
KR (1) KR20070091662A (el)
AR (1) AR052830A1 (el)
AU (2) AU2005318190B2 (el)
BR (1) BRPI0517132B8 (el)
CA (2) CA2588966C (el)
CY (3) CY1112614T1 (el)
DK (3) DK3332789T3 (el)
EA (1) EA015799B1 (el)
ES (2) ES2921858T3 (el)
FI (1) FI4070800T3 (el)
FR (1) FR18C1008I2 (el)
HR (1) HRP20120228T1 (el)
HU (3) HUE070333T2 (el)
IL (2) IL183930A0 (el)
LT (3) LT4070800T (el)
LU (1) LUC00064I2 (el)
MX (1) MX2007007610A (el)
NO (1) NO20073813L (el)
PL (4) PL2805723T3 (el)
SG (1) SG160391A1 (el)
SI (3) SI2805723T1 (el)
WO (1) WO2006067141A1 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0517132B8 (pt) 2004-12-22 2021-05-25 Laboratoires Serono S A uso de cladribina para preparação de uma formulação farmacêutica para tratamento de esclerose múltipla
CA2649810A1 (en) * 2006-05-24 2007-11-29 Laboratoires Serono S.A. Cladribine regimen for treating multiple sclerosis
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
WO2011117267A1 (en) 2010-03-24 2011-09-29 Merck Serono Sa Cladribine treatment of multiple sclerosis in patient groups defined by genotype
EP2428201A1 (en) 2010-09-08 2012-03-14 Merck Serono S.A. Oral administration of nucleoside monophosphates
WO2012097867A1 (en) 2011-01-18 2012-07-26 Synthon Bv Cladribine particles and pharmaceutical compositions comprising them
GB201401465D0 (en) 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
GB2564717A (en) 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
CN119097635A (zh) * 2017-11-24 2024-12-10 默克专利股份公司 用于治疗进展型形式的多发性硬化症的克拉屈滨疗法
US20240226284A1 (en) 2020-09-10 2024-07-11 Merck Patent Gmbh Novel treatment regimen for the treatment of autoimmune disorders
GB2601786A (en) * 2020-12-10 2022-06-15 Chord Therapeutics S A R L Use of cladribine for treating immune brain disease

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1269659A (en) 1984-08-06 1990-05-29 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
US4964848A (en) * 1988-06-27 1990-10-23 Bloom Philip M Treatment of multiple sclerosis with lymphocytapheresis and chemo-immunosuppression
US5208327A (en) 1991-12-18 1993-05-04 Ortho Pharmaceutical Corporation Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine
US5641757A (en) 1994-12-21 1997-06-24 Ortho Pharmaceutical Corporation Stable 2-chloro-2'-deoxyadenosine formulations
JPH10512549A (ja) 1994-12-22 1998-12-02 オーソ・フアーマシユーチカル・コーポレーシヨン 可溶性の2−クロロ−2’−デオキシアデノシン配合物
US6194395B1 (en) 1999-02-25 2001-02-27 Orthro-Mcneil Pharmaceutical, Inc. Cyclodextrin cladribine formulations
WO2000064918A1 (en) 1999-04-28 2000-11-02 Sterrenbeld Biotechnologie North America, Inc. METHOD FOR THE PRODUCTION OF 2-CHLORO-2'-DEOXYADENOSINE (CLADRIBINE) AND ITS 3,5-DI-O-p-TOLUOYL DERIVATIVE
DE10237146A1 (de) * 2002-08-13 2004-03-04 Medac Gesellschaft für klinische Spezialpräparate mbH Verwendung von Treosulfan und Derivaten davon zur Behandlung der Multiplen Sklerose
EP1556400B1 (en) 2002-09-25 2013-05-01 Brigham Young University Method for the preparation of 2-halo-2 -deoxyadenosine compounds from 2 -deoxyguanosine
GB2394658A (en) * 2002-11-01 2004-05-05 Cancer Rec Tech Ltd Oral anti-cancer composition
EP1596873A1 (en) * 2003-02-25 2005-11-23 Applied Research Systems ARS Holding N.V. Combined use of ribavirin and interferon beta in demyelinating diseases
ES2584183T3 (es) 2003-03-28 2016-09-26 Ares Trading S.A. Formulaciones de cladribina para suministro mejorado oral y transmucosa
HRP20050925A2 (en) 2003-03-28 2006-08-31 Ivax Corporation Oral formulations of cladribine
BRPI0517132B8 (pt) 2004-12-22 2021-05-25 Laboratoires Serono S A uso de cladribina para preparação de uma formulação farmacêutica para tratamento de esclerose múltipla
CA2649810A1 (en) * 2006-05-24 2007-11-29 Laboratoires Serono S.A. Cladribine regimen for treating multiple sclerosis

Also Published As

Publication number Publication date
LTPA2018503I1 (lt) 2018-03-12
JP6092945B2 (ja) 2017-03-08
CA3087419C (en) 2023-03-07
CY1119790T1 (el) 2018-06-27
EP4070800B1 (en) 2024-10-16
CY2018006I1 (el) 2018-06-27
EP4070800A1 (en) 2022-10-12
US7713947B2 (en) 2010-05-11
NO20073813L (no) 2007-09-21
DK2805723T3 (da) 2018-01-29
LT4070800T (lt) 2025-01-10
EP2805723B1 (en) 2018-01-17
JP5795456B2 (ja) 2015-10-14
JP5908863B2 (ja) 2016-04-26
US8377903B2 (en) 2013-02-19
EP1827461A1 (en) 2007-09-05
ES3007339T3 (en) 2025-03-19
FR18C1008I2 (fr) 2019-03-01
CA2588966C (en) 2020-07-21
AU2011200768A1 (en) 2011-03-17
EP1827461B1 (en) 2012-02-29
JP2015180685A (ja) 2015-10-15
LUC00064I1 (el) 2018-02-14
CA3087419A1 (en) 2006-06-29
AR052830A1 (es) 2007-04-04
EP2275110A2 (en) 2011-01-19
JP2020193206A (ja) 2020-12-03
PL1827461T3 (pl) 2012-07-31
EP3332789B1 (en) 2022-04-06
EP2263678A2 (en) 2010-12-22
MX2007007610A (es) 2007-08-03
HUE070333T2 (hu) 2025-05-28
LUC00064I2 (el) 2018-03-28
AU2005318190B2 (en) 2010-11-25
CA2588966A1 (en) 2006-06-29
AU2011200768B2 (en) 2012-09-13
AU2005318190A1 (en) 2006-06-29
BRPI0517132A (pt) 2008-09-30
US20100203017A1 (en) 2010-08-12
IL212421A (en) 2014-01-30
EA200701221A1 (ru) 2008-02-28
SI2805723T1 (en) 2018-02-28
LTC2805723I2 (lt) 2022-04-25
FR18C1008I1 (el) 2018-03-30
FI4070800T3 (fi) 2025-01-14
PL4070800T3 (pl) 2025-03-10
EP2275110A3 (en) 2011-04-27
EP4523753A3 (en) 2025-05-28
JP2017101061A (ja) 2017-06-08
EP4523753A2 (en) 2025-03-19
JP6290962B2 (ja) 2018-03-07
JP2008524313A (ja) 2008-07-10
EP2263678A3 (en) 2011-04-27
EA015799B1 (ru) 2011-12-30
JP2013216664A (ja) 2013-10-24
PL3332789T3 (pl) 2022-08-22
KR20070091662A (ko) 2007-09-11
CY1112614T1 (el) 2016-02-10
BRPI0517132B8 (pt) 2021-05-25
SG160391A1 (en) 2010-04-29
HUS1800009I1 (hu) 2018-05-02
ES2921858T3 (es) 2022-09-01
EP2275110B1 (en) 2013-07-10
BRPI0517132B1 (pt) 2020-02-18
WO2006067141A1 (en) 2006-06-29
JP6430554B2 (ja) 2018-11-28
IL212421A0 (en) 2011-06-30
SI3332789T1 (sl) 2022-08-31
LT3332789T (lt) 2022-07-25
EP3332789A1 (en) 2018-06-13
JP2016138128A (ja) 2016-08-04
JP2018165271A (ja) 2018-10-25
IL183930A0 (en) 2007-10-31
PL2805723T3 (pl) 2018-04-30
SI4070800T1 (sl) 2025-03-31
EP2805723A1 (en) 2014-11-26
HRP20120228T1 (hr) 2012-04-30
HUE059133T2 (hu) 2022-10-28
EP2263678B1 (en) 2014-06-11
US20090081163A1 (en) 2009-03-26
DK3332789T3 (da) 2022-07-11
DK4070800T3 (da) 2025-01-02

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