DK4070800T3 - Cladribinkur til behandling af multipel sklerose - Google Patents

Cladribinkur til behandling af multipel sklerose Download PDF

Info

Publication number: DK4070800T3
Authority: DK; Denmark
Prior art keywords: sclerosa; cladribine; treatment; multiple sclerosa
Prior art date: 2004-12-22

Application number

DK22166610.0T

Other languages

English (en)

Inventor

Luca Giampiero De

Arnaud Ythier

Alain Munafo

Maria Lopez-Bresnahan

Original Assignee

Merck Serono Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-22

Filing date

2005-12-20

Publication date

2025-01-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36227798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK4070800(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-12-20 Application filed by Merck Serono Sa filed Critical Merck Serono Sa

2025-01-02 Application granted granted Critical

2025-01-02 Publication of DK4070800T3 publication Critical patent/DK4070800T3/da

Links

PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 title 1
229960002436 cladribine Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

DK22166610.0T 2004-12-22 2005-12-20 Cladribinkur til behandling af multipel sklerose DK4070800T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US63866904P	2004-12-22	2004-12-22
EP04106909		2004-12-22
EP18151634.5A EP3332789B1 (en)	2004-12-22	2005-12-20	Cladribine regimen for treating multiple sclerosis

Publications (1)

Publication Number	Publication Date
DK4070800T3 true DK4070800T3 (da)	2025-01-02

Family

ID=36227798

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK18151634.5T DK3332789T3 (da)	2004-12-22	2005-12-20	Cladribinkur til behandling af multipel sklerose
DK14001970.4T DK2805723T3 (da)	2004-12-22	2005-12-20	Cladribin-regime til behandling af multipel sclerose
DK22166610.0T DK4070800T3 (da)	2004-12-22	2005-12-20	Cladribinkur til behandling af multipel sklerose

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK18151634.5T DK3332789T3 (da)	2004-12-22	2005-12-20	Cladribinkur til behandling af multipel sklerose
DK14001970.4T DK2805723T3 (da)	2004-12-22	2005-12-20	Cladribin-regime til behandling af multipel sclerose

Country Status (25)

Country	Link
US (2)	US7713947B2 (da)
EP (7)	EP3332789B1 (da)
JP (7)	JP5795456B2 (da)
KR (1)	KR20070091662A (da)
AR (1)	AR052830A1 (da)
AU (2)	AU2005318190B2 (da)
BR (1)	BRPI0517132B8 (da)
CA (2)	CA2588966C (da)
CY (3)	CY1112614T1 (da)
DK (3)	DK3332789T3 (da)
EA (1)	EA015799B1 (da)
ES (2)	ES2921858T3 (da)
FI (1)	FI4070800T3 (da)
FR (1)	FR18C1008I2 (da)
HR (1)	HRP20120228T1 (da)
HU (3)	HUE070333T2 (da)
IL (2)	IL183930A0 (da)
LT (3)	LT4070800T (da)
LU (1)	LUC00064I2 (da)
MX (1)	MX2007007610A (da)
NO (1)	NO20073813L (da)
PL (4)	PL2805723T3 (da)
SG (1)	SG160391A1 (da)
SI (3)	SI2805723T1 (da)
WO (1)	WO2006067141A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0517132B8 (pt)	2004-12-22	2021-05-25	Laboratoires Serono S A	uso de cladribina para preparação de uma formulação farmacêutica para tratamento de esclerose múltipla
CA2649810A1 (en) *	2006-05-24	2007-11-29	Laboratoires Serono S.A.	Cladribine regimen for treating multiple sclerosis
EP2343074A1 (en)	2009-12-23	2011-07-13	Merck Serono S.A.	Use of purine analogues for treating airway diseases
WO2011117267A1 (en)	2010-03-24	2011-09-29	Merck Serono Sa	Cladribine treatment of multiple sclerosis in patient groups defined by genotype
EP2428201A1 (en)	2010-09-08	2012-03-14	Merck Serono S.A.	Oral administration of nucleoside monophosphates
WO2012097867A1 (en)	2011-01-18	2012-07-26	Synthon Bv	Cladribine particles and pharmaceutical compositions comprising them
GB201401465D0 (en)	2014-01-29	2014-03-12	Roach Arthur H	Use of cladribine for treating autoimmune inflammatory disease
GB2564717A (en)	2017-07-21	2019-01-23	Chord Therapeutics S A R L	Use of cladribine for treating autoimmune neuromuscular disease
CN119097635A (zh) *	2017-11-24	2024-12-10	默克专利股份公司	用于治疗进展型形式的多发性硬化症的克拉屈滨疗法
US20240226284A1 (en)	2020-09-10	2024-07-11	Merck Patent Gmbh	Novel treatment regimen for the treatment of autoimmune disorders
GB2601786A (en) *	2020-12-10	2022-06-15	Chord Therapeutics S A R L	Use of cladribine for treating immune brain disease

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1269659A (en)	1984-08-06	1990-05-29	Brigham Young University	Method for the production of 2'-deoxyadenosine compounds
US5310732A (en) *	1986-02-03	1994-05-10	The Scripps Research Institute	2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
US4964848A (en) *	1988-06-27	1990-10-23	Bloom Philip M	Treatment of multiple sclerosis with lymphocytapheresis and chemo-immunosuppression
US5208327A (en)	1991-12-18	1993-05-04	Ortho Pharmaceutical Corporation	Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine
US5641757A (en)	1994-12-21	1997-06-24	Ortho Pharmaceutical Corporation	Stable 2-chloro-2'-deoxyadenosine formulations
JPH10512549A (ja)	1994-12-22	1998-12-02	オーソ・フアーマシユーチカル・コーポレーシヨン	可溶性の２−クロロ−２’−デオキシアデノシン配合物
US6194395B1 (en)	1999-02-25	2001-02-27	Orthro-Mcneil Pharmaceutical, Inc.	Cyclodextrin cladribine formulations
WO2000064918A1 (en)	1999-04-28	2000-11-02	Sterrenbeld Biotechnologie North America, Inc.	METHOD FOR THE PRODUCTION OF 2-CHLORO-2'-DEOXYADENOSINE (CLADRIBINE) AND ITS 3,5-DI-O-p-TOLUOYL DERIVATIVE
DE10237146A1 (de) *	2002-08-13	2004-03-04	Medac Gesellschaft für klinische Spezialpräparate mbH	Verwendung von Treosulfan und Derivaten davon zur Behandlung der Multiplen Sklerose
EP1556400B1 (en)	2002-09-25	2013-05-01	Brigham Young University	Method for the preparation of 2-halo-2 -deoxyadenosine compounds from 2 -deoxyguanosine
GB2394658A (en) *	2002-11-01	2004-05-05	Cancer Rec Tech Ltd	Oral anti-cancer composition
EP1596873A1 (en) *	2003-02-25	2005-11-23	Applied Research Systems ARS Holding N.V.	Combined use of ribavirin and interferon beta in demyelinating diseases
ES2584183T3 (es)	2003-03-28	2016-09-26	Ares Trading S.A.	Formulaciones de cladribina para suministro mejorado oral y transmucosa
HRP20050925A2 (en)	2003-03-28	2006-08-31	Ivax Corporation	Oral formulations of cladribine
BRPI0517132B8 (pt)	2004-12-22	2021-05-25	Laboratoires Serono S A	uso de cladribina para preparação de uma formulação farmacêutica para tratamento de esclerose múltipla
CA2649810A1 (en) *	2006-05-24	2007-11-29	Laboratoires Serono S.A.	Cladribine regimen for treating multiple sclerosis

2005
- 2005-12-20 BR BRPI0517132A patent/BRPI0517132B8/pt active IP Right Grant
- 2005-12-20 DK DK18151634.5T patent/DK3332789T3/da active
- 2005-12-20 EP EP18151634.5A patent/EP3332789B1/en not_active Expired - Lifetime
- 2005-12-20 EP EP05823474A patent/EP1827461B1/en not_active Expired - Lifetime
- 2005-12-20 FI FIEP22166610.0T patent/FI4070800T3/fi active
- 2005-12-20 SI SI200532191T patent/SI2805723T1/en unknown
- 2005-12-20 PL PL14001970T patent/PL2805723T3/pl unknown
- 2005-12-20 MX MX2007007610A patent/MX2007007610A/es unknown
- 2005-12-20 PL PL18151634.5T patent/PL3332789T3/pl unknown
- 2005-12-20 EP EP14001970.4A patent/EP2805723B1/en not_active Revoked
- 2005-12-20 ES ES18151634T patent/ES2921858T3/es not_active Expired - Lifetime
- 2005-12-20 SG SG201001736-6A patent/SG160391A1/en unknown
- 2005-12-20 SI SI200532321T patent/SI4070800T1/sl unknown
- 2005-12-20 EP EP24206496.2A patent/EP4523753A3/en not_active Withdrawn
- 2005-12-20 LT LTEP22166610.0T patent/LT4070800T/lt unknown
- 2005-12-20 WO PCT/EP2005/056954 patent/WO2006067141A1/en not_active Ceased
- 2005-12-20 DK DK14001970.4T patent/DK2805723T3/da active
- 2005-12-20 SI SI200532305T patent/SI3332789T1/sl unknown
- 2005-12-20 KR KR1020077016508A patent/KR20070091662A/ko not_active Ceased
- 2005-12-20 US US11/722,018 patent/US7713947B2/en active Active
- 2005-12-20 EP EP10182676.6A patent/EP2263678B1/en not_active Expired - Lifetime
- 2005-12-20 JP JP2007547486A patent/JP5795456B2/ja not_active Expired - Lifetime
- 2005-12-20 HU HUE22166610A patent/HUE070333T2/hu unknown
- 2005-12-20 DK DK22166610.0T patent/DK4070800T3/da active
- 2005-12-20 CA CA2588966A patent/CA2588966C/en not_active Expired - Lifetime
- 2005-12-20 PL PL22166610.0T patent/PL4070800T3/pl unknown
- 2005-12-20 LT LTEP18151634.5T patent/LT3332789T/lt unknown
- 2005-12-20 HR HR20120228T patent/HRP20120228T1/hr unknown
- 2005-12-20 AU AU2005318190A patent/AU2005318190B2/en not_active Expired
- 2005-12-20 ES ES22166610T patent/ES3007339T3/es not_active Expired - Lifetime
- 2005-12-20 EP EP10182632.9A patent/EP2275110B1/en not_active Expired - Lifetime
- 2005-12-20 PL PL05823474T patent/PL1827461T3/pl unknown
- 2005-12-20 EA EA200701221A patent/EA015799B1/ru active Protection Beyond IP Right Term
- 2005-12-20 EP EP22166610.0A patent/EP4070800B1/en not_active Revoked
- 2005-12-20 CA CA3087419A patent/CA3087419C/en not_active Expired - Lifetime
- 2005-12-20 HU HUE18151634A patent/HUE059133T2/hu unknown
- 2005-12-21 AR ARP050105411A patent/AR052830A1/es not_active Application Discontinuation
2007
- 2007-06-14 IL IL183930A patent/IL183930A0/en active IP Right Grant
- 2007-07-20 NO NO20073813A patent/NO20073813L/no not_active Application Discontinuation
2010
- 2010-04-23 US US12/766,173 patent/US8377903B2/en active Active
2011
- 2011-02-23 AU AU2011200768A patent/AU2011200768B2/en not_active Expired
- 2011-04-17 IL IL212421A patent/IL212421A/en active IP Right Grant
2012
- 2012-04-11 CY CY20121100358T patent/CY1112614T1/el unknown
2013
- 2013-05-30 JP JP2013113850A patent/JP5908863B2/ja not_active Expired - Lifetime
2015
- 2015-06-16 JP JP2015120875A patent/JP6092945B2/ja not_active Expired - Lifetime
2016
- 2016-04-08 JP JP2016078293A patent/JP6290962B2/ja not_active Expired - Lifetime
2017
- 2017-02-09 JP JP2017022375A patent/JP6430554B2/ja not_active Expired - Lifetime
2018
- 2018-01-18 CY CY20181100065T patent/CY1119790T1/el unknown
- 2018-02-12 LU LU00064C patent/LUC00064I2/fr unknown
- 2018-02-14 FR FR18C1008C patent/FR18C1008I2/fr active Active
- 2018-02-15 HU HUS1800009C patent/HUS1800009I1/hu unknown
- 2018-02-20 LT LTPA2018503C patent/LTC2805723I2/lt unknown
- 2018-02-28 CY CY2018006C patent/CY2018006I2/el unknown
- 2018-07-09 JP JP2018129918A patent/JP2018165271A/ja active Pending
2020
- 2020-08-06 JP JP2020134010A patent/JP2020193206A/ja active Pending

Also Published As

Publication number	Publication date
LTPA2018503I1 (lt)	2018-03-12
JP6092945B2 (ja)	2017-03-08
CA3087419C (en)	2023-03-07
CY1119790T1 (el)	2018-06-27
EP4070800B1 (en)	2024-10-16
CY2018006I1 (el)	2018-06-27
EP4070800A1 (en)	2022-10-12
US7713947B2 (en)	2010-05-11
NO20073813L (no)	2007-09-21
DK2805723T3 (da)	2018-01-29
LT4070800T (lt)	2025-01-10
EP2805723B1 (en)	2018-01-17
JP5795456B2 (ja)	2015-10-14
JP5908863B2 (ja)	2016-04-26
US8377903B2 (en)	2013-02-19
EP1827461A1 (en)	2007-09-05
ES3007339T3 (en)	2025-03-19
FR18C1008I2 (fr)	2019-03-01
CA2588966C (en)	2020-07-21
AU2011200768A1 (en)	2011-03-17
EP1827461B1 (en)	2012-02-29
JP2015180685A (ja)	2015-10-15
LUC00064I1 (da)	2018-02-14
CA3087419A1 (en)	2006-06-29
AR052830A1 (es)	2007-04-04
EP2275110A2 (en)	2011-01-19
JP2020193206A (ja)	2020-12-03
PL1827461T3 (pl)	2012-07-31
EP3332789B1 (en)	2022-04-06
EP2263678A2 (en)	2010-12-22
MX2007007610A (es)	2007-08-03
HUE070333T2 (hu)	2025-05-28
LUC00064I2 (da)	2018-03-28
AU2005318190B2 (en)	2010-11-25
CA2588966A1 (en)	2006-06-29
AU2011200768B2 (en)	2012-09-13
AU2005318190A1 (en)	2006-06-29
BRPI0517132A (pt)	2008-09-30
US20100203017A1 (en)	2010-08-12
IL212421A (en)	2014-01-30
EA200701221A1 (ru)	2008-02-28
SI2805723T1 (en)	2018-02-28
LTC2805723I2 (lt)	2022-04-25
FR18C1008I1 (da)	2018-03-30
FI4070800T3 (fi)	2025-01-14
PL4070800T3 (pl)	2025-03-10
EP2275110A3 (en)	2011-04-27
EP4523753A3 (en)	2025-05-28
JP2017101061A (ja)	2017-06-08
EP4523753A2 (en)	2025-03-19
JP6290962B2 (ja)	2018-03-07
JP2008524313A (ja)	2008-07-10
EP2263678A3 (en)	2011-04-27
EA015799B1 (ru)	2011-12-30
JP2013216664A (ja)	2013-10-24
PL3332789T3 (pl)	2022-08-22
KR20070091662A (ko)	2007-09-11
CY1112614T1 (el)	2016-02-10
BRPI0517132B8 (pt)	2021-05-25
SG160391A1 (en)	2010-04-29
HUS1800009I1 (hu)	2018-05-02
ES2921858T3 (es)	2022-09-01
EP2275110B1 (en)	2013-07-10
BRPI0517132B1 (pt)	2020-02-18
WO2006067141A1 (en)	2006-06-29
JP6430554B2 (ja)	2018-11-28
IL212421A0 (en)	2011-06-30
SI3332789T1 (sl)	2022-08-31
LT3332789T (lt)	2022-07-25
CY2018006I2 (el)	2018-06-27
EP3332789A1 (en)	2018-06-13
JP2016138128A (ja)	2016-08-04
JP2018165271A (ja)	2018-10-25
IL183930A0 (en)	2007-10-31
PL2805723T3 (pl)	2018-04-30
SI4070800T1 (sl)	2025-03-31
EP2805723A1 (en)	2014-11-26
HRP20120228T1 (hr)	2012-04-30
HUE059133T2 (hu)	2022-10-28
EP2263678B1 (en)	2014-06-11
US20090081163A1 (en)	2009-03-26
DK3332789T3 (da)	2022-07-11

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