LU80297A1 - Amides tetrapeptidiques a activite pharmacologique,procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Amides tetrapeptidiques a activite pharmacologique,procede pour leur preparation et compositions pharmaceutiques les contenant Download PDF

Info

Publication number: LU80297A1
Authority: LU; Luxembourg
Prior art keywords: methyl; tyrosyl; phenylalanine; alanylglycyl; compound
Prior art date: 1977-09-29

Application number

LU80297A

Other languages

English (en)

French (fr)

Inventor

B Handa

M Rance

B Morgan

Original Assignee

Reckitt & Colmann Prod Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-09-29

Filing date

1978-09-28

Publication date

1980-04-21

1978-09-28 Application filed by Reckitt & Colmann Prod Ltd filed Critical Reckitt & Colmann Prod Ltd

1980-04-21 Publication of LU80297A1 publication Critical patent/LU80297A1/fr

Links

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UEJYSALTSUZXFV-SRVKXCTJSA-N Rigin Chemical compound NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O UEJYSALTSUZXFV-SRVKXCTJSA-N 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
241000906446 Theraps Species 0.000 description 1
PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 description 1
239000000556 agonist Substances 0.000 description 1
235000004279 alanine Nutrition 0.000 description 1
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 1
125000005741 alkyl alkenyl group Chemical group 0.000 description 1
125000003368 amide group Chemical group 0.000 description 1
150000003862 amino acid derivatives Chemical class 0.000 description 1
229940124277 aminobutyric acid Drugs 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
230000003042 antagnostic effect Effects 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
229940125714 antidiarrheal agent Drugs 0.000 description 1
239000003793 antidiarrheal agent Substances 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 1
UWTDFICHZKXYAC-UHFFFAOYSA-N boron;oxolane Chemical compound [B].C1CCOC1 UWTDFICHZKXYAC-UHFFFAOYSA-N 0.000 description 1
239000002775 capsule Substances 0.000 description 1
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 description 1
230000002920 convulsive effect Effects 0.000 description 1
239000013078 crystal Substances 0.000 description 1
125000004981 cycloalkylmethyl group Chemical group 0.000 description 1
230000000994 depressogenic effect Effects 0.000 description 1
238000010511 deprotection reaction Methods 0.000 description 1
238000001514 detection method Methods 0.000 description 1
UXGNZZKBCMGWAZ-UHFFFAOYSA-N dimethylformamide dmf Chemical compound CN(C)C=O.CN(C)C=O UXGNZZKBCMGWAZ-UHFFFAOYSA-N 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003480 eluent Substances 0.000 description 1
238000010828 elution Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
IIEWJVIFRVWJOD-UHFFFAOYSA-N ethyl cyclohexane Natural products CCC1CCCCC1 IIEWJVIFRVWJOD-UHFFFAOYSA-N 0.000 description 1
239000012634 fragment Substances 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
108010081551 glycylphenylalanine Proteins 0.000 description 1
239000008187 granular material Substances 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
229960005015 local anesthetics Drugs 0.000 description 1
239000000463 material Substances 0.000 description 1
BGZYZJSBQPNKKC-UHFFFAOYSA-N n-methyl-3-methylsulfanylpropan-1-amine Chemical compound CNCCCSC BGZYZJSBQPNKKC-UHFFFAOYSA-N 0.000 description 1
239000003887 narcotic antagonist Substances 0.000 description 1
230000003533 narcotic effect Effects 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
PSACHCMMPFMFAJ-UHFFFAOYSA-N nmm n-methylmorpholine Chemical compound CN1CCOCC1.CN1CCOCC1 PSACHCMMPFMFAJ-UHFFFAOYSA-N 0.000 description 1
239000012044 organic layer Substances 0.000 description 1
AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
239000012071 phase Substances 0.000 description 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
230000001012 protector Effects 0.000 description 1
JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical group C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
230000004044 response Effects 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
210000002460 smooth muscle Anatomy 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000012265 solid product Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000000021 stimulant Substances 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
239000012258 stirred mixture Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
230000029305 taxis Effects 0.000 description 1
238000009864 tensile test Methods 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
108010022199 tyrosyl-alanyl-glycyl-phenylalanine Proteins 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Anesthesiology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

LU80297A 1977-09-29 1978-09-28 Amides tetrapeptidiques a activite pharmacologique,procede pour leur preparation et compositions pharmaceutiques les contenant LU80297A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB4047677		1977-09-29
GB4047677		1977-09-29

Publications (1)

Publication Number	Publication Date
LU80297A1 true LU80297A1 (fr)	1980-04-21

Family

ID=10415092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU80297A LU80297A1 (fr)	1977-09-29	1978-09-28	Amides tetrapeptidiques a activite pharmacologique,procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (14)

Country	Link
US (1)	US4199568A (it)
JP (1)	JPS5463044A (it)
AU (1)	AU523886B2 (it)
BE (1)	BE870867A (it)
CH (1)	CH634291A5 (it)
DE (1)	DE2841591A1 (it)
DK (1)	DK430578A (it)
FR (1)	FR2404628A1 (it)
IT (1)	IT1099662B (it)
LU (1)	LU80297A1 (it)
NL (1)	NL7809733A (it)
NZ (1)	NZ188372A (it)
SE (1)	SE7810199L (it)
ZA (1)	ZA785160B (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0076557B1 (en) *	1981-06-22	1985-11-13	Imperial Chemical Industries Plc	Peptides and pseudopeptides in which the n terminus bears two substituents
JPS604163A (ja) *	1983-06-21	1985-01-10	Taiho Yakuhin Kogyo Kk	スルフアイド化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2702711A1 (de) *	1976-02-02	1977-08-04	Sandoz Ag	Neue organische verbindungen, ihre herstellung und verwendung
FR2359817A1 (fr) *	1976-07-27	1978-02-24	Reckitt & Colmann Prod Ltd	Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant

1978
- 1978-09-07 NZ NZ188372A patent/NZ188372A/xx unknown
- 1978-09-12 ZA ZA00785160A patent/ZA785160B/xx unknown
- 1978-09-13 US US05/941,757 patent/US4199568A/en not_active Expired - Lifetime
- 1978-09-22 AU AU40097/78A patent/AU523886B2/en not_active Expired
- 1978-09-25 DE DE19782841591 patent/DE2841591A1/de not_active Withdrawn
- 1978-09-26 NL NL7809733A patent/NL7809733A/xx not_active Application Discontinuation
- 1978-09-26 CH CH1003578A patent/CH634291A5/fr not_active IP Right Cessation
- 1978-09-28 LU LU80297A patent/LU80297A1/fr unknown
- 1978-09-28 DK DK430578A patent/DK430578A/da unknown
- 1978-09-28 SE SE7810199A patent/SE7810199L/xx unknown
- 1978-09-28 FR FR7827801A patent/FR2404628A1/fr active Pending
- 1978-09-28 BE BE6046619A patent/BE870867A/xx unknown
- 1978-09-29 IT IT28232/78A patent/IT1099662B/it active
- 1978-09-29 JP JP12113778A patent/JPS5463044A/ja active Pending

Also Published As

Publication number	Publication date
AU523886B2 (en)	1982-08-19
DE2841591A1 (de)	1979-04-12
NZ188372A (en)	1981-05-01
NL7809733A (nl)	1979-04-02
US4199568A (en)	1980-04-22
JPS5463044A (en)	1979-05-21
AU4009778A (en)	1980-03-27
IT1099662B (it)	1985-09-28
CH634291A5 (fr)	1983-01-31
FR2404628A1 (fr)	1979-04-27
ZA785160B (en)	1979-08-29
IT7828232A0 (it)	1978-09-29
DK430578A (da)	1979-03-30
SE7810199L (sv)	1979-03-30
BE870867A (fr)	1979-03-28

Publication	Publication Date	Title
EP0038758B1 (fr)	1985-03-06	Dérivés d'acides aminés et leur application thérapeutique
EP0517589B1 (fr)	1996-12-27	Dérivés de tachykinines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0082088B1 (fr)	1986-04-02	Nouveaux dérivés d'aminoacides, et leur application thérapeutique
DE69130408T2 (de)	1999-03-18	Endothelinantagonistische Peptidderivate
MC1881A1 (fr)	1989-01-24	Derives de l'acide phosphinique
JPS6253952A (ja)	1987-03-09	レニン阻害剤製造用中間体の立体選択的製法
JPH06293795A (ja)	1994-10-21	ペンタペプチドアミド類
FR2609991A1 (fr)	1988-07-29	Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments
JP4417551B2 (ja)	2010-02-17	ヘミアスターリン類似体
CH638177A5 (fr)	1983-09-15	Derives de peptides.
EP0614886A1 (en)	1994-09-14	Compound capable of intracerebral residence and use thereof
FR2717484A1 (fr)	1995-09-22	Nouveaux composés pseudo-bis-peptidiques analogues de la CCK, leur procédé de préparation, leur utilisation à titre de médicament et les compositions pharmaceutiques les comprenant .
EP0131500B1 (fr)	1987-05-20	Nouveaux agents radioprotecteurs ayant une structure amino-thioalkyle et procédé pour leur préparation
EP1140822A1 (fr)	2001-10-10	Nouveaux derives actives stables d'acide carbamique, leur procede de preparation et leur utilisation pour la preparation d'urees
FR2585708A1 (fr)	1987-02-06	Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
HU182866B (en)	1984-03-28	Process for preparing new tetrapeptide derivatives
FR2564845A1 (fr)	1985-11-29	Mercaptocycloalkylcarbonyl et mercaptoarylcarbonyl dipeptides a action therapeutique
EP0005658A1 (fr)	1979-11-28	Nouveaux dérivés de peptides analogues des enképhalines, leur procédé de préparation et leur application thérapeutique
JPH10500123A (ja)	1998-01-06	アミノスルホン酸の誘導体、プソイドペプチドの合成における同誘導体の利用、およびその製造法
HU185022B (en)	1984-11-28	Process for the preparation of biologically active tetrapeptide derivatives
FR2471971A1 (fr)	1981-06-26	Tetrapeptides homologues des enkephalines, leur preparation et leur utilisation therapeutique
FR2471969A1 (fr)	1981-06-26	Pentapeptides homologues d'enkephalines, leur preparation et leur utilisation therapeutique
EP0562659B1 (fr)	1997-12-17	Procédé de synthèse peptidique et nouveaux intermédiaires de synthèse
CH634291A5 (fr)	1983-01-31	Peptides.
EP0354108A1 (fr)	1990-02-07	Amino-acides et peptides présentant un résidu tyrosine modifiée, leur préparation et leur application comme médicaments