LU81923A1 - 1,2,4,5-tetra-alkyl-4-arylpiperidines,leur utilisation therapeutique,leur preparation et les intermediaires appropries - Google Patents

1,2,4,5-tetra-alkyl-4-arylpiperidines,leur utilisation therapeutique,leur preparation et les intermediaires appropries Download PDF

Info

Publication number
LU81923A1
LU81923A1 LU81923A LU81923A LU81923A1 LU 81923 A1 LU81923 A1 LU 81923A1 LU 81923 A LU81923 A LU 81923A LU 81923 A LU81923 A LU 81923A LU 81923 A1 LU81923 A1 LU 81923A1
Authority
LU
Luxembourg
Prior art keywords
formula
piperidine
group
propyl
alkyl
Prior art date
Application number
LU81923A
Other languages
English (en)
French (fr)
Inventor
D Zimmerman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of LU81923A1 publication Critical patent/LU81923A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
LU81923A 1978-11-29 1979-11-26 1,2,4,5-tetra-alkyl-4-arylpiperidines,leur utilisation therapeutique,leur preparation et les intermediaires appropries LU81923A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96513778 1978-11-29
US05/965,137 US4284635A (en) 1978-11-29 1978-11-29 Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines

Publications (1)

Publication Number Publication Date
LU81923A1 true LU81923A1 (fr) 1980-04-22

Family

ID=25509504

Family Applications (1)

Application Number Title Priority Date Filing Date
LU81923A LU81923A1 (fr) 1978-11-29 1979-11-26 1,2,4,5-tetra-alkyl-4-arylpiperidines,leur utilisation therapeutique,leur preparation et les intermediaires appropries

Country Status (26)

Country Link
US (1) US4284635A (es)
EP (1) EP0013078A3 (es)
JP (1) JPS5573657A (es)
KR (1) KR830001214A (es)
AR (1) AR224138A1 (es)
AT (1) ATA750879A (es)
AU (1) AU529136B2 (es)
BE (1) BE880220A (es)
CA (1) CA1121357A (es)
DD (1) DD147537A5 (es)
DK (1) DK504979A (es)
EG (1) EG14137A (es)
ES (2) ES8101551A1 (es)
FI (1) FI793663A7 (es)
FR (2) FR2442836A1 (es)
GB (1) GB2038812B (es)
GR (1) GR72292B (es)
HU (1) HU178532B (es)
IL (1) IL58793A0 (es)
IT (1) IT1126406B (es)
LU (1) LU81923A1 (es)
PH (1) PH15420A (es)
PL (1) PL123672B1 (es)
PT (1) PT70486A (es)
SU (1) SU967275A3 (es)
ZA (1) ZA796336B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212183A (en) * 1981-11-14 1993-05-18 Basf Aktiengesellschaft 4-(p-tert.-butylphenyl)-3-methylpiperidines substituted at the nitrogen, their quaternary salts and their use as fungicides
US4485109A (en) * 1982-05-07 1984-11-27 E. I. Du Pont De Nemours And Company 4-Aryl-4-piperidinecarbinols
US4581456A (en) * 1983-09-21 1986-04-08 Eli Lilly And Company Processes for preparing picenadol precursors and novel intermediates thereof
ZW10287A1 (en) * 1986-07-15 1988-01-13 Hoffmann La Roche Tetrahydronaphthaline and indane derivatives
EP0299549A3 (en) * 1987-07-09 1989-02-08 Duphar International Research B.V Tertiary 2,5-dialkyl-3-phenyl-piperidine derivatives having opiate-antagonistic activity
CA1337418C (en) * 1988-03-28 1995-10-24 Engelbert Ciganek 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
US5136040A (en) * 1991-02-26 1992-08-04 Eli Lilly And Company Preparation of substituted tetrahydropyridines
US5270328A (en) * 1991-03-29 1993-12-14 Eli Lilly And Company Peripherally selective piperidine opioid antagonists
US5250542A (en) * 1991-03-29 1993-10-05 Eli Lilly And Company Peripherally selective piperidine carboxylate opioid antagonists
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912416D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912417D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2892842A (en) * 1959-06-30 Their preparation
US2956058A (en) * 1957-08-19 1960-10-11 Lilly Co Eli Novel substituted piperidines and pyrrolidines
US3043845A (en) * 1958-12-29 1962-07-10 Abbott Lab Phenylmethylpiperidine derivatives
US3080372A (en) * 1960-03-25 1963-03-05 Res Lab Dr C Janssen 1-aroylalkyl-4-arylpiperidine derivatives
NL123743C (es) * 1963-09-18
US3574219A (en) * 1967-09-27 1971-04-06 Tanabe Seiyaku Co 1-(beta-hydroxyphenethyl)-2,3-dimethyl-3-(3-hydroxyphenyl)-piperidine
US3936468A (en) * 1969-10-27 1976-02-03 Sumitomo Chemical Company, Ltd. Phenylbutanol derivatives
GB1403942A (en) * 1973-04-05 1975-08-28 Ciba Geigy Ag Piperidine derivatives
AR206937A1 (es) * 1974-09-06 1976-08-31 Lilly Co Eli Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina
US4115400A (en) * 1976-05-27 1978-09-19 Eli Lilly And Company 1-Azoniabicyclo[3.1.0]hexanes
ZA777356B (en) * 1976-12-17 1979-01-31 Rohm & Haas Arthropod repellents

Also Published As

Publication number Publication date
EP0013078A2 (en) 1980-07-09
PH15420A (en) 1983-01-07
EG14137A (en) 1983-09-30
ES486425A0 (es) 1980-12-16
AU5310079A (en) 1980-05-29
AU529136B2 (en) 1983-05-26
FR2442836A1 (fr) 1980-06-27
BE880220A (fr) 1980-05-23
ES493915A0 (es) 1981-11-16
KR830001214A (ko) 1983-04-29
FR2453154B1 (es) 1983-05-27
AR224138A1 (es) 1981-10-30
ES8101551A1 (es) 1980-12-16
CA1121357A (en) 1982-04-06
GR72292B (es) 1983-10-17
DD147537A5 (de) 1981-04-08
ATA750879A (de) 1983-03-15
PL123672B1 (en) 1982-11-30
ES8200664A1 (es) 1981-11-16
PT70486A (en) 1979-12-01
FR2453154A1 (fr) 1980-10-31
IT1126406B (it) 1986-05-21
JPS5573657A (en) 1980-06-03
DK504979A (da) 1980-05-30
PL219885A1 (es) 1980-12-01
ZA796336B (en) 1981-06-24
GB2038812B (en) 1983-01-06
EP0013078A3 (en) 1980-10-01
US4284635A (en) 1981-08-18
FR2442836B1 (es) 1983-07-29
IL58793A0 (en) 1980-02-29
FI793663A7 (fi) 1980-05-30
GB2038812A (en) 1980-07-30
IT7927614A0 (it) 1979-11-27
SU967275A3 (ru) 1982-10-15
HU178532B (en) 1982-05-28

Similar Documents

Publication Publication Date Title
EP0837848B1 (fr) 4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines ayant une activite neurotrophique et neuroprotectrice
EP0975595B1 (en) Analogs of cocaine
KR0131377B1 (ko) 1, 4-이치환-피페리디닐 화합물
LU79761A1 (fr) Procede de preparation de nouveaux composes de phtalazine et de composition pharmaceutique les contenant
FR2531707A1 (fr) Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques
US4284635A (en) Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines
FR2582309A1 (fr) Nouveaux derives du morphinane et de la morphine, leur preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
EP0031753B1 (fr) Nouveaux dérivés de la (pipéridyl-4)-2 (quinolyl-4)-1 éthanone, produits intermédiaires et procédés pour leur préparation, et leur utilisation comme médicaments
EP1050531B1 (fr) Composés pyridiniques ou pipéridiniques substitués pour le traitement des maladies neurodégénératives
CA1095047A (fr) Procede de preparation de nouveaux derives du 1,4- benzodioxane
EP0937043B1 (fr) Nouveaux derives tetrahydropyridiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CH661046A5 (fr) Derives de benzodioxinopyrrole et procedes de preparation.
BE1008622A3 (fr) Derives de l'epi-epibatidine.
HU185432B (en) Process for producing indene derivatives
EP1050530B1 (fr) 1-Aza-2-Alkyl-6-Aryl-Cycloalcanes utiles pour améliorer la mémoire
US4228288A (en) Certain substituted 3,4,5,6-tetrahydropyridinium salt intermediates
WO2004043952A1 (fr) Nouveaux derives de 2,3-dihydro-4(1h)-pyridinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
LU82235A1 (fr) Phenylmorphanes, intermediaires et procedes de synthese, et leur utilisation therapeutique
EP0060176A1 (fr) Trifluorométhylphényltétrahydropyridines substituées à activité anorexigène, un procédé de préparation et compositions pharmaceutiques
EP1790646A1 (fr) Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3.
LU82115A1 (fr) Nouvelles quinazolines anti-hypertensives,leur procede de production et composition pharmaceutique les contenant
FR2463129A1 (fr) Derives de la 4-(naphtalenyloxy)-piperidine, leur preparation et leurs utilisations antipsychotiques
FR2508043A1 (fr) Derives d'aporphine efficaces par voie orale et leur procede de fabrication
FR2521136A1 (fr) Derives de piperidine, leur preparation et leur application en therapeutique
FR2462426A1 (fr) Nouveau derive de la 2-(1-naphtyl)piperidine, sa preparation et son application comme medicament