LU85161A1 - Nouveaux conjugues de la vinblastine,leur procede de preparation et leur utilisation therapeutique - Google Patents

Nouveaux conjugues de la vinblastine,leur procede de preparation et leur utilisation therapeutique Download PDF

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Publication number
LU85161A1
LU85161A1 LU85161A LU85161A LU85161A1 LU 85161 A1 LU85161 A1 LU 85161A1 LU 85161 A LU85161 A LU 85161A LU 85161 A LU85161 A LU 85161A LU 85161 A1 LU85161 A1 LU 85161A1
Authority
LU
Luxembourg
Prior art keywords
group
protein
vinblastine
derivatives
derivative according
Prior art date
Application number
LU85161A
Other languages
English (en)
French (fr)
Inventor
Andre Trouet
Jean Hannart
Kandukuri Sivaprasade Bhus Rao
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnichem Sa filed Critical Omnichem Sa
Priority to LU85161A priority Critical patent/LU85161A1/fr
Priority to IL71642A priority patent/IL71642A/xx
Priority to DE8484870057T priority patent/DE3484691D1/de
Priority to HU841610A priority patent/HUT34212A/hu
Priority to GR74519A priority patent/GR81790B/el
Priority to AT84870057T priority patent/ATE64396T1/de
Priority to EP84870057A priority patent/EP0124502B1/de
Priority to PT78508A priority patent/PT78508B/pt
Priority to DK210784A priority patent/DK210784A/da
Priority to OA58284A priority patent/OA07711A/xx
Priority to AU27434/84A priority patent/AU575819B2/en
Priority to ES531965A priority patent/ES531965A0/es
Priority to NZ207992A priority patent/NZ207992A/en
Priority to CA000453143A priority patent/CA1234800A/en
Priority to DD84263250A priority patent/DD219771A5/de
Priority to PH30778A priority patent/PH21394A/en
Publication of LU85161A1 publication Critical patent/LU85161A1/fr
Priority to US06/854,909 priority patent/US4870162A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LU85161A 1983-04-29 1983-12-29 Nouveaux conjugues de la vinblastine,leur procede de preparation et leur utilisation therapeutique LU85161A1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
LU85161A LU85161A1 (fr) 1983-12-29 1983-12-29 Nouveaux conjugues de la vinblastine,leur procede de preparation et leur utilisation therapeutique
IL71642A IL71642A (en) 1983-12-29 1984-04-25 Galactosylated human albumin conjugates of vinblastine derivatives,their preparation and pharmaceutical compositions containing them
DE8484870057T DE3484691D1 (de) 1983-04-29 1984-04-26 Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
HU841610A HUT34212A (en) 1983-04-29 1984-04-26 Process for the production of new vindblastin conjugates
GR74519A GR81790B (de) 1983-04-29 1984-04-26
AT84870057T ATE64396T1 (de) 1983-04-29 1984-04-26 Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
EP84870057A EP0124502B1 (de) 1983-04-29 1984-04-26 Konjugierte Vinblastin-Verbindungen und ihre Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
PT78508A PT78508B (en) 1983-04-29 1984-04-27 Process for the preparation of new vinblastine coupled
DK210784A DK210784A (da) 1983-04-29 1984-04-27 Konjugater af vinblastin eller vinblastinderivater og fremgangsmaade til fremstilling deraf
OA58284A OA07711A (fr) 1983-04-29 1984-04-27 Nouveaux conjugués de la vinblastine, leur procédé de préparation et leur utilisation thérapeutique.
AU27434/84A AU575819B2 (en) 1983-04-29 1984-04-27 Vinblastine conjugates
ES531965A ES531965A0 (es) 1983-04-29 1984-04-27 Procedimiento de preparar compuestos vinblastinicos y similares
NZ207992A NZ207992A (en) 1983-04-29 1984-04-30 Vinblastine conjugates and pharmaceutical compositions
CA000453143A CA1234800A (en) 1983-04-29 1984-04-30 Processes for the preparation of new conjugates of vinblastine or of vinblastine derivatives and the products of such processes
DD84263250A DD219771A5 (de) 1983-12-29 1984-05-22 Verfahren zur herstellung neuer konjugierter verbindungen von vinblastin und seinen derivaten
PH30778A PH21394A (en) 1983-12-29 1984-06-06 New conjugates of vinblastine, a process for their preparation and their use in therapy
US06/854,909 US4870162A (en) 1983-04-29 1986-04-23 Conjugates of vinblastine, a process for their preparation and their use in therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU85161A LU85161A1 (fr) 1983-12-29 1983-12-29 Nouveaux conjugues de la vinblastine,leur procede de preparation et leur utilisation therapeutique
LU85161 1983-12-29

Publications (1)

Publication Number Publication Date
LU85161A1 true LU85161A1 (fr) 1985-09-12

Family

ID=19730204

Family Applications (1)

Application Number Title Priority Date Filing Date
LU85161A LU85161A1 (fr) 1983-04-29 1983-12-29 Nouveaux conjugues de la vinblastine,leur procede de preparation et leur utilisation therapeutique

Country Status (4)

Country Link
DD (1) DD219771A5 (de)
IL (1) IL71642A (de)
LU (1) LU85161A1 (de)
PH (1) PH21394A (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216228B2 (en) 2007-02-16 2015-12-22 KTB Tumorforschungsgesellschaft MBM Receptor and antigen targeted prodrug

Also Published As

Publication number Publication date
DD219771A5 (de) 1985-03-13
PH21394A (en) 1987-10-15
IL71642A (en) 1990-11-05

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