LU85829A1 - Composition pour bains a base de psoralene dans le traitement du psoriasis - Google Patents

Composition pour bains a base de psoralene dans le traitement du psoriasis Download PDF

Info

Publication number: LU85829A1
Authority: LU; Luxembourg
Prior art keywords: polyoxyethylenated; composition; weight; fatty; psoralen
Prior art date: 1985-04-01

Application number

LU85829A

Other languages

English (en)

French (fr)

Inventor

Braham Shroot

Original Assignee

Cird

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-01

Filing date

1985-04-01

Publication date

1986-11-05

1985-04-01 Application filed by Cird filed Critical Cird

1985-04-01 Priority to LU85829A priority Critical patent/LU85829A1/fr

1986-03-26 Priority to DK143086A priority patent/DK165664C/da

1986-03-27 Priority to ZA862349A priority patent/ZA862349B/xx

1986-03-27 Priority to CA000505381A priority patent/CA1274177A/fr

1986-03-27 Priority to AU55343/86A priority patent/AU591107B2/en

1986-03-28 Priority to DE8686400693T priority patent/DE3674619D1/de

1986-03-28 Priority to EP86400693A priority patent/EP0197856B1/fr

1986-03-28 Priority to IL78307A priority patent/IL78307A0/xx

1986-03-28 Priority to JP61072388A priority patent/JPS61236722A/ja

1986-03-28 Priority to DE198686400693T priority patent/DE197856T1/de

1986-11-05 Publication of LU85829A1 publication Critical patent/LU85829A1/fr

1989-03-16 Priority to US07/324,130 priority patent/US4983625A/en

Links

239000000203 mixture Substances 0.000 title claims description 27
ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 title claims description 16
238000011282 treatment Methods 0.000 title claims description 13
201000004681 Psoriasis Diseases 0.000 title claims description 5
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 20
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
150000001875 compounds Chemical class 0.000 claims description 10
150000002191 fatty alcohols Chemical class 0.000 claims description 9
SQBBOVROCFXYBN-UHFFFAOYSA-N methoxypsoralen Natural products C1=C2OC(=O)C(OC)=CC2=CC2=C1OC=C2 SQBBOVROCFXYBN-UHFFFAOYSA-N 0.000 claims description 8
VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 claims description 7
BGEBZHIAGXMEMV-UHFFFAOYSA-N 5-methoxypsoralen Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OC BGEBZHIAGXMEMV-UHFFFAOYSA-N 0.000 claims description 7
-1 polyoxypropylene Polymers 0.000 claims description 7
235000014113 dietary fatty acids Nutrition 0.000 claims description 6
150000002148 esters Chemical class 0.000 claims description 6
239000000194 fatty acid Substances 0.000 claims description 6
229930195729 fatty acid Natural products 0.000 claims description 6
150000004665 fatty acids Chemical class 0.000 claims description 6
229960004469 methoxsalen Drugs 0.000 claims description 6
229920006395 saturated elastomer Polymers 0.000 claims description 6
FMHHVULEAZTJMA-UHFFFAOYSA-N trioxsalen Chemical compound CC1=CC(=O)OC2=C1C=C1C=C(C)OC1=C2C FMHHVULEAZTJMA-UHFFFAOYSA-N 0.000 claims description 6
BUNGCZLFHHXKBX-UHFFFAOYSA-N 8-methoxypsoralen Natural products C1=CC(=O)OC2=C1C=C1CCOC1=C2OC BUNGCZLFHHXKBX-UHFFFAOYSA-N 0.000 claims description 5
150000002194 fatty esters Chemical class 0.000 claims description 5
229960002045 bergapten Drugs 0.000 claims description 4
KGZDKFWCIPZMRK-UHFFFAOYSA-N bergapten Natural products COC1C2=C(Cc3ccoc13)C=CC(=O)O2 KGZDKFWCIPZMRK-UHFFFAOYSA-N 0.000 claims description 4
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 claims description 3
239000000600 sorbitol Substances 0.000 claims description 3
CFQAMEDTKHNQTP-UHFFFAOYSA-N 3-(ethoxycarbonyl)psoralen Chemical compound C1=C2OC(=O)C(C(=O)OCC)=CC2=CC2=C1OC=C2 CFQAMEDTKHNQTP-UHFFFAOYSA-N 0.000 claims description 2
235000013162 Cocos nucifera Nutrition 0.000 claims description 2
244000060011 Cocos nucifera Species 0.000 claims description 2
239000003945 anionic surfactant Substances 0.000 claims description 2
150000002193 fatty amides Chemical class 0.000 claims description 2
229930195733 hydrocarbon Natural products 0.000 claims description 2
150000002430 hydrocarbons Chemical class 0.000 claims description 2
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 2
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 2
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 2
229920001451 polypropylene glycol Polymers 0.000 claims 2
239000004215 Carbon black (E152) Substances 0.000 claims 1
239000005639 Lauric acid Substances 0.000 claims 1
229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
239000002253 acid Substances 0.000 claims 1
150000004671 saturated fatty acids Chemical class 0.000 claims 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
150000004670 unsaturated fatty acids Chemical class 0.000 claims 1
235000021122 unsaturated fatty acids Nutrition 0.000 claims 1
239000003921 oil Substances 0.000 description 6
235000019198 oils Nutrition 0.000 description 6
210000003491 skin Anatomy 0.000 description 6
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 5
229920000136 polysorbate Polymers 0.000 description 5
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 4
239000005977 Ethylene Substances 0.000 description 4
239000002202 Polyethylene glycol Substances 0.000 description 4
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 4
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 4
235000019271 petrolatum Nutrition 0.000 description 4
229920001223 polyethylene glycol Polymers 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
125000004432 carbon atom Chemical group C* 0.000 description 3
229940071160 cocoate Drugs 0.000 description 3
LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 3
235000019197 fats Nutrition 0.000 description 3
150000003626 triacylglycerols Chemical class 0.000 description 3
229960000850 trioxysalen Drugs 0.000 description 3
ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 2
101710179734 6,7-dimethyl-8-ribityllumazine synthase 2 Proteins 0.000 description 2
101710186609 Lipoyl synthase 2 Proteins 0.000 description 2
101710122908 Lipoyl synthase 2, chloroplastic Proteins 0.000 description 2
101710101072 Lipoyl synthase 2, mitochondrial Proteins 0.000 description 2
229920001213 Polysorbate 20 Polymers 0.000 description 2
WPMWEFXCIYCJSA-UHFFFAOYSA-N Tetraethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCO WPMWEFXCIYCJSA-UHFFFAOYSA-N 0.000 description 2
RKZXQQPEDGMHBJ-LIGJGSPWSA-N [(2s,3r,4r,5r)-2,3,4,5,6-pentakis[[(z)-octadec-9-enoyl]oxy]hexyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC RKZXQQPEDGMHBJ-LIGJGSPWSA-N 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
239000004359 castor oil Substances 0.000 description 2
235000019438 castor oil Nutrition 0.000 description 2
ALSTYHKOOCGGFT-UHFFFAOYSA-N cis-oleyl alcohol Natural products CCCCCCCCC=CCCCCCCCCO ALSTYHKOOCGGFT-UHFFFAOYSA-N 0.000 description 2
GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical class CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
230000007928 solubilization Effects 0.000 description 2
238000005063 solubilization Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
CKNOIIXFUKKRIC-HZJYTTRNSA-N (9z,12z)-n,n-bis(2-hydroxyethyl)octadeca-9,12-dienamide Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)N(CCO)CCO CKNOIIXFUKKRIC-HZJYTTRNSA-N 0.000 description 1
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
LGEZTMRIZWCDLW-UHFFFAOYSA-N 14-methylpentadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC(C)C LGEZTMRIZWCDLW-UHFFFAOYSA-N 0.000 description 1
MUHFRORXWCGZGE-KTKRTIGZSA-N 2-hydroxyethyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCO MUHFRORXWCGZGE-KTKRTIGZSA-N 0.000 description 1
XLMXUUQMSMKFMH-UZRURVBFSA-N 2-hydroxyethyl (z,12r)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC(=O)OCCO XLMXUUQMSMKFMH-UZRURVBFSA-N 0.000 description 1
LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
DBMJZOMNXBSRED-UHFFFAOYSA-N Bergamottin Natural products O1C(=O)C=CC2=C1C=C1OC=CC1=C2OCC=C(C)CCC=C(C)C DBMJZOMNXBSRED-UHFFFAOYSA-N 0.000 description 1
IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
239000005642 Oleic acid Substances 0.000 description 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000004147 Sorbitan trioleate Substances 0.000 description 1
PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 1
206010047642 Vitiligo Diseases 0.000 description 1
PCWZKQSKUXXDDJ-UHFFFAOYSA-N Xanthotoxin Natural products COCc1c2OC(=O)C=Cc2cc3ccoc13 PCWZKQSKUXXDDJ-UHFFFAOYSA-N 0.000 description 1
239000013543 active substance Substances 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000470 constituent Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
238000007865 diluting Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
230000000694 effects Effects 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000005187 foaming Methods 0.000 description 1
229940095098 glycol oleate Drugs 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
XDROKJSWHURZGO-UHFFFAOYSA-N isopsoralen Natural products C1=C2OC=CC2=C2OC(=O)C=CC2=C1 XDROKJSWHURZGO-UHFFFAOYSA-N 0.000 description 1
229940070765 laurate Drugs 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000011418 maintenance treatment Methods 0.000 description 1
238000000034 method Methods 0.000 description 1
201000005962 mycosis fungoides Diseases 0.000 description 1
SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
230000002215 photochemotherapeutic effect Effects 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
MLMVLVJMKDPYBM-UHFFFAOYSA-N pseudoisopsoralene Natural products C1=C2C=COC2=C2OC(=O)C=CC2=C1 MLMVLVJMKDPYBM-UHFFFAOYSA-N 0.000 description 1
230000005855 radiation Effects 0.000 description 1
KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
229950005143 sitosterol Drugs 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
239000000243 solution Substances 0.000 description 1
229940035044 sorbitan monolaurate Drugs 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
235000019337 sorbitan trioleate Nutrition 0.000 description 1
229960000391 sorbitan trioleate Drugs 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1
229940099259 vaseline Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Birds (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Cosmetics (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

LU85829A 1985-04-01 1985-04-01 Composition pour bains a base de psoralene dans le traitement du psoriasis LU85829A1 (fr)

Priority Applications (11)

Application Number	Priority Date	Filing Date	Title
LU85829A LU85829A1 (fr)	1985-04-01	1985-04-01	Composition pour bains a base de psoralene dans le traitement du psoriasis
DK143086A DK165664C (da)	1985-04-01	1986-03-26	Psoralen-badpraeparat til behandling af psoriasis og andre hudsygdomme
ZA862349A ZA862349B (en)	1985-04-01	1986-03-27	Psoralene-based bath compositions for treatment of skin disorders
CA000505381A CA1274177A (fr)	1985-04-01	1986-03-27	Composition pour bains a base de psoralenes dans le traitement du psoriasis
AU55343/86A AU591107B2 (en)	1985-04-01	1986-03-27	Psoralene-based bath compositions for treatment of skin disorders
DE8686400693T DE3674619D1 (de)	1985-04-01	1986-03-28	Zusammensetzung fuer baeder auf basis von psoralen in der behandlung von psoriasis.
EP86400693A EP0197856B1 (fr)	1985-04-01	1986-03-28	Composition pour bains à base de psoralène dans le traitement du psoriasis
IL78307A IL78307A0 (en)	1985-04-01	1986-03-28	Psoralene-based bath composition for treatment of skin disorders
JP61072388A JPS61236722A (ja)	1985-04-01	1986-03-28	皮膚疾患処置用プソラレン含有入浴剤組成物
DE198686400693T DE197856T1 (de)	1985-04-01	1986-03-28	Zusammensetzung fuer baeder auf basis von psoralen in der behandlung von psoriasis.
US07/324,130 US4983625A (en)	1985-04-01	1989-03-16	Psoralene-based bath compositions for treatment of skin disorders

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
LU85829		1985-04-01
LU85829A LU85829A1 (fr)	1985-04-01	1985-04-01	Composition pour bains a base de psoralene dans le traitement du psoriasis

Publications (1)

Publication Number	Publication Date
LU85829A1 true LU85829A1 (fr)	1986-11-05

Family

ID=19730430

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU85829A LU85829A1 (fr)	1985-04-01	1985-04-01	Composition pour bains a base de psoralene dans le traitement du psoriasis

Country Status (10)

Country	Link
US (1)	US4983625A (da)
EP (1)	EP0197856B1 (da)
JP (1)	JPS61236722A (da)
AU (1)	AU591107B2 (da)
CA (1)	CA1274177A (da)
DE (2)	DE3674619D1 (da)
DK (1)	DK165664C (da)
IL (1)	IL78307A0 (da)
LU (1)	LU85829A1 (da)
ZA (1)	ZA862349B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2606637A1 (fr) *	1986-11-18	1988-05-20	Meyer Raoul	Utilisation de sels de cobalt, en cosmetique contre le vieillissement de la peau
US5116864A (en) *	1991-04-09	1992-05-26	Indiana University Foundation	Method for preventing restenosis following reconfiguration of body vessels
DE4205548C3 (de) *	1992-02-24	1998-07-23	Merz & Co Gmbh & Co	Bade- und Duschzusatz mit vesikelbildenden Eigenschaften, seine Herstellung und Verwendung
FR2695036B1 (fr) *	1992-09-03	1994-10-28	Goupil Jean Jacques	Huile contenant du 5-méthoxypsoralène à une concentration de 60 à 100 PPM et son utilisation pour le traitement du psoriasis.
GB2318291B (en) *	1996-10-15	1998-09-23	Robin Morley	8-Methoxypsoralen containing additives for topical application in bath water
JP4655853B2 (ja) *	2005-09-30	2011-03-23	日油株式会社	入浴剤組成物
SI24952A (sl) *	2015-03-25	2016-09-30	Univerza V Ljubljani	Derivati psoralena kot nepeptidni zaviralci kimotripsinske aktivnosti imunoproteasoma

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE445422B (sv) *	1979-06-25	1986-06-23	Gerot Pharmazeutika	Farmaceutisk beredning for oral administereing innehallande 8-metoxi-furo-/3',2':6,7/-kumarin
CA1173751A (en) *	1980-05-07	1984-09-04	Jack H. Lazarus	Methoxsalen dosage forms

1985
- 1985-04-01 LU LU85829A patent/LU85829A1/fr unknown
1986
- 1986-03-26 DK DK143086A patent/DK165664C/da not_active Application Discontinuation
- 1986-03-27 AU AU55343/86A patent/AU591107B2/en not_active Ceased
- 1986-03-27 ZA ZA862349A patent/ZA862349B/xx unknown
- 1986-03-27 CA CA000505381A patent/CA1274177A/fr not_active Expired - Lifetime
- 1986-03-28 DE DE8686400693T patent/DE3674619D1/de not_active Expired - Lifetime
- 1986-03-28 EP EP86400693A patent/EP0197856B1/fr not_active Expired - Lifetime
- 1986-03-28 DE DE198686400693T patent/DE197856T1/de active Pending
- 1986-03-28 IL IL78307A patent/IL78307A0/xx unknown
- 1986-03-28 JP JP61072388A patent/JPS61236722A/ja active Pending
1989
- 1989-03-16 US US07/324,130 patent/US4983625A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK143086A (da)	1986-10-02
AU591107B2 (en)	1989-11-30
DK165664C (da)	1993-11-08
ZA862349B (en)	1986-11-26
US4983625A (en)	1991-01-08
AU5534386A (en)	1986-10-09
DE197856T1 (de)	1987-04-30
CA1274177A (fr)	1990-09-18
DK143086D0 (da)	1986-03-26
EP0197856B1 (fr)	1990-10-03
JPS61236722A (ja)	1986-10-22
IL78307A0 (en)	1986-07-31
DE3674619D1 (de)	1990-11-08
EP0197856A1 (fr)	1986-10-15
DK165664B (da)	1993-01-04

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