LU86020A1 - Du traitement des etats hypotrophiques - Google Patents
Du traitement des etats hypotrophiques Download PDFInfo
- Publication number
- LU86020A1 LU86020A1 LU86020A LU86020A LU86020A1 LU 86020 A1 LU86020 A1 LU 86020A1 LU 86020 A LU86020 A LU 86020A LU 86020 A LU86020 A LU 86020A LU 86020 A1 LU86020 A1 LU 86020A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- arginine
- treatment
- arginine aspartate
- dose
- children
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims description 8
- 230000000729 hypotrophic effect Effects 0.000 title claims description 4
- SUUWYOYAXFUOLX-ZBRNBAAYSA-N (2s)-2-aminobutanedioic acid;(2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O.OC(=O)[C@@H](N)CCCN=C(N)N SUUWYOYAXFUOLX-ZBRNBAAYSA-N 0.000 claims description 18
- 229960002223 arginine aspartate Drugs 0.000 claims description 18
- 206010053759 Growth retardation Diseases 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 231100000001 growth retardation Toxicity 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 235000012054 meals Nutrition 0.000 claims description 2
- 208000037824 growth disorder Diseases 0.000 claims 1
- 230000001969 hypertrophic effect Effects 0.000 claims 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 10
- 101710144202 Probable soluble pyridine nucleotide transhydrogenase Proteins 0.000 description 9
- 241000700159 Rattus Species 0.000 description 9
- 102100028023 Saitohin Human genes 0.000 description 9
- 101710165942 Soluble pyridine nucleotide transhydrogenase Proteins 0.000 description 9
- 239000004475 Arginine Substances 0.000 description 6
- 102000018997 Growth Hormone Human genes 0.000 description 6
- 108010051696 Growth Hormone Proteins 0.000 description 6
- 229960003121 arginine Drugs 0.000 description 6
- 239000000122 growth hormone Substances 0.000 description 6
- 230000028327 secretion Effects 0.000 description 6
- 102000004877 Insulin Human genes 0.000 description 5
- 108090001061 Insulin Proteins 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 235000009697 arginine Nutrition 0.000 description 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 5
- 229940125396 insulin Drugs 0.000 description 5
- 102000051325 Glucagon Human genes 0.000 description 4
- 108060003199 Glucagon Proteins 0.000 description 4
- 230000006735 deficit Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 4
- 229960004666 glucagon Drugs 0.000 description 4
- 229940088597 hormone Drugs 0.000 description 4
- 239000005556 hormone Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 230000003248 secreting effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000001195 anabolic effect Effects 0.000 description 2
- 229960005261 aspartic acid Drugs 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000001483 arginine derivatives Chemical class 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007665 chronic toxicity Effects 0.000 description 1
- 231100000160 chronic toxicity Toxicity 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000008807 pathological lesion Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 231100000456 subacute toxicity Toxicity 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8411835 | 1984-07-24 | ||
| FR8411835A FR2568124B1 (fr) | 1984-07-24 | 1984-07-24 | Medicament pour traiter les etats hypotrophiques par administrations d'aspartate d'arginine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU86020A1 true LU86020A1 (fr) | 1986-02-12 |
Family
ID=9306499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU86020A LU86020A1 (fr) | 1984-07-24 | 1985-07-24 | Du traitement des etats hypotrophiques |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS6137734A (pt) |
| AU (1) | AU574811B2 (pt) |
| BE (1) | BE902954A (pt) |
| CH (1) | CH660689A5 (pt) |
| DE (1) | DE3439805C2 (pt) |
| DZ (1) | DZ699A1 (pt) |
| FR (1) | FR2568124B1 (pt) |
| IT (1) | IT1177368B (pt) |
| LU (1) | LU86020A1 (pt) |
| MA (1) | MA20290A1 (pt) |
| NL (1) | NL8502100A (pt) |
| OA (1) | OA07878A (pt) |
| PT (1) | PT79617A (pt) |
| ZA (1) | ZA851683B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5019558A (en) * | 1988-05-09 | 1991-05-28 | Georges Cehovic | Method for treating memory disturbances using arginine aspartate |
| DE19705233A1 (de) * | 1997-02-12 | 1998-08-13 | Froelich Juergen C | Verfahren zur Herstellung einer Formulierung enthaltend Arginin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR106F (pt) * | 1964-12-21 | |||
| IT1131854B (it) * | 1980-06-30 | 1986-06-25 | Baldacci Lab Spa | Composizione farmaceutica per uso terapeutico,per uso diagnostico e quale integratore alimentare |
| FR2547501A1 (fr) * | 1983-06-15 | 1984-12-21 | Opochimiotherapie Lab | Excipient effervescent, sans alcalino-terreux, contenant des composes carbonates de l'arginine et un acide, et comprimes effervescents correspondants |
-
1984
- 1984-07-24 FR FR8411835A patent/FR2568124B1/fr not_active Expired
- 1984-10-31 DE DE3439805A patent/DE3439805C2/de not_active Expired - Lifetime
- 1984-11-10 DZ DZ847325A patent/DZ699A1/fr active
- 1984-11-19 JP JP24431884A patent/JPS6137734A/ja active Pending
- 1984-11-23 CH CH5615/84A patent/CH660689A5/fr not_active IP Right Cessation
- 1984-11-27 OA OA58455A patent/OA07878A/xx unknown
- 1984-11-29 IT IT23800/84A patent/IT1177368B/it active
- 1984-12-03 MA MA20514A patent/MA20290A1/fr unknown
- 1984-12-05 PT PT79617A patent/PT79617A/pt unknown
-
1985
- 1985-03-06 ZA ZA851683A patent/ZA851683B/xx unknown
- 1985-07-22 NL NL8502100A patent/NL8502100A/nl not_active Application Discontinuation
- 1985-07-22 BE BE0/215391A patent/BE902954A/fr not_active IP Right Cessation
- 1985-07-23 AU AU45273/85A patent/AU574811B2/en not_active Expired
- 1985-07-24 LU LU86020A patent/LU86020A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3439805C2 (de) | 1994-01-20 |
| ZA851683B (en) | 1986-01-29 |
| OA07878A (fr) | 1986-11-20 |
| IT8423800A1 (it) | 1986-05-29 |
| MA20290A1 (fr) | 1985-07-01 |
| PT79617A (en) | 1985-01-01 |
| FR2568124A1 (fr) | 1986-01-31 |
| BE902954A (fr) | 1986-01-22 |
| CH660689A5 (fr) | 1987-06-15 |
| DE3439805A1 (de) | 1986-02-06 |
| JPS6137734A (ja) | 1986-02-22 |
| IT1177368B (it) | 1987-08-26 |
| NL8502100A (nl) | 1986-02-17 |
| FR2568124B1 (fr) | 1988-12-09 |
| IT8423800A0 (it) | 1984-11-29 |
| DZ699A1 (fr) | 2004-09-13 |
| AU4527385A (en) | 1986-01-30 |
| AU574811B2 (en) | 1988-07-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DT | Application date | ||
| TA | Annual fee |