LU86958A1 - Sels d'acide thiamorpholinone carboxylique et de derives de diamino-2,4 pyrimidine,leur utilisation en cosmetique et pharmacie - Google Patents

Sels d'acide thiamorpholinone carboxylique et de derives de diamino-2,4 pyrimidine,leur utilisation en cosmetique et pharmacie Download PDF

Info

Publication number: LU86958A1
Authority: LU; Luxembourg
Prior art keywords: thiamorpholinone; diamino; piperidino; carboxylate; pyrimidine
Prior art date: 1987-07-31

Application number

LU86958A

Other languages

English (en)

French (fr)

Inventor

Jean Maignan

Gerard Lang

Serge Restle

Original Assignee

Oreal

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-31

Filing date

1987-07-31

Publication date

1989-03-08

1987-07-31 Application filed by Oreal filed Critical Oreal

1987-07-31 Priority to LU86958A priority Critical patent/LU86958A1/fr

1988-07-26 Priority to EP88112024A priority patent/EP0304649B1/de

1988-07-26 Priority to DE8888112024T priority patent/DE3862083D1/de

1988-07-26 Priority to AT88112024T priority patent/ATE61801T1/de

1988-07-29 Priority to CA000573492A priority patent/CA1314884C/fr

1988-07-29 Priority to US07/225,818 priority patent/US4970063A/en

1988-07-29 Priority to JP63188534A priority patent/JPS6450867A/ja

1989-03-08 Publication of LU86958A1 publication Critical patent/LU86958A1/fr

1991-05-20 Priority to GR91400638T priority patent/GR3001965T3/el

Links

239000002537 cosmetic Substances 0.000 title claims description 9
YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical class NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 title description 7
150000001732 carboxylic acid derivatives Chemical class 0.000 title description 4
150000001875 compounds Chemical class 0.000 claims abstract description 11
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 3
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 3
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 28
239000000203 mixture Substances 0.000 claims description 24
210000004761 scalp Anatomy 0.000 claims description 8
201000004384 Alopecia Diseases 0.000 claims description 7
230000000699 topical effect Effects 0.000 claims description 7
238000011282 treatment Methods 0.000 claims description 7
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
230000003676 hair loss Effects 0.000 claims description 4
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
239000006210 lotion Substances 0.000 claims description 4
238000000034 method Methods 0.000 claims description 4
206010039792 Seborrhoea Diseases 0.000 claims description 3
231100000360 alopecia Toxicity 0.000 claims description 3
239000012736 aqueous medium Substances 0.000 claims description 3
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
208000024963 hair loss Diseases 0.000 claims description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
HWYHDWGGACRVEH-UHFFFAOYSA-N n-methyl-n-(4-pyrrolidin-1-ylbut-2-ynyl)acetamide Chemical compound CC(=O)N(C)CC#CCN1CCCC1 HWYHDWGGACRVEH-UHFFFAOYSA-N 0.000 claims description 3
239000008194 pharmaceutical composition Substances 0.000 claims description 3
208000008742 seborrheic dermatitis Diseases 0.000 claims description 3
PNCWHIAZZSDHPU-UHFFFAOYSA-N 2-benzylsulfanylethanamine Chemical compound NCCSCC1=CC=CC=C1 PNCWHIAZZSDHPU-UHFFFAOYSA-N 0.000 claims description 2
201000004624 Dermatitis Diseases 0.000 claims description 2
239000000443 aerosol Substances 0.000 claims description 2
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
239000004202 carbamide Substances 0.000 claims description 2
239000006071 cream Substances 0.000 claims description 2
239000000499 gel Substances 0.000 claims description 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
239000004310 lactic acid Substances 0.000 claims description 2
235000014655 lactic acid Nutrition 0.000 claims description 2
125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 2
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
239000002904 solvent Substances 0.000 claims description 2
-1 alkyl radical Chemical class 0.000 claims 2
PQGAHNJECSVDEI-UHFFFAOYSA-N [CH2]CCCCC Chemical group [CH2]CCCCC PQGAHNJECSVDEI-UHFFFAOYSA-N 0.000 claims 1
230000003779 hair growth Effects 0.000 claims 1
230000001939 inductive effect Effects 0.000 claims 1
230000004936 stimulating effect Effects 0.000 claims 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 42
150000003839 salts Chemical class 0.000 description 24
239000002253 acid Substances 0.000 description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
230000015572 biosynthetic process Effects 0.000 description 6
238000003786 synthesis reaction Methods 0.000 description 6
ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 5
238000009835 boiling Methods 0.000 description 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
150000001734 carboxylic acid salts Chemical class 0.000 description 4
229910052739 hydrogen Inorganic materials 0.000 description 4
238000002844 melting Methods 0.000 description 4
230000008018 melting Effects 0.000 description 4
229960003632 minoxidil Drugs 0.000 description 4
239000013543 active substance Substances 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
238000009472 formulation Methods 0.000 description 3
238000001953 recrystallisation Methods 0.000 description 3
IPFIEHIRBSTAKA-UHFFFAOYSA-N 6-piperidin-1-ylpyrimidine-2,4-diamine Chemical compound NC1=NC(N)=CC(N2CCCCC2)=N1 IPFIEHIRBSTAKA-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
230000001476 alcoholic effect Effects 0.000 description 2
208000004631 alopecia areata Diseases 0.000 description 2
239000013078 crystal Substances 0.000 description 2
239000003814 drug Substances 0.000 description 2
238000000921 elemental analysis Methods 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
230000002335 preservative effect Effects 0.000 description 2
SAALQYKUFCIMHR-UHFFFAOYSA-N propan-2-ol;2-propan-2-yloxypropane Chemical compound CC(C)O.CC(C)OC(C)C SAALQYKUFCIMHR-UHFFFAOYSA-N 0.000 description 2
239000011541 reaction mixture Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical class CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
NBAJYWQRWMFKCA-UHFFFAOYSA-N 5-piperidin-1-ylpyrimidine-2,4-diamine Chemical compound NC1=NC(N)=NC=C1N1CCCCC1 NBAJYWQRWMFKCA-UHFFFAOYSA-N 0.000 description 1
241000928106 Alain Species 0.000 description 1
LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical class COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000011149 active material Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
230000003276 anti-hypertensive effect Effects 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003974 emollient agent Substances 0.000 description 1
230000003203 everyday effect Effects 0.000 description 1
230000003659 hair regrowth Effects 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
231100001231 less toxic Toxicity 0.000 description 1
239000002609 medium Substances 0.000 description 1
PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
239000000155 melt Substances 0.000 description 1
230000003020 moisturizing effect Effects 0.000 description 1
238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
230000035515 penetration Effects 0.000 description 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
239000004584 polyacrylic acid Substances 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
239000002453 shampoo Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
230000029305 taxis Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
SLYPOVJCSQHITR-UHFFFAOYSA-N tioxolone Chemical compound OC1=CC=C2SC(=O)OC2=C1 SLYPOVJCSQHITR-UHFFFAOYSA-N 0.000 description 1
229960003070 tioxolone Drugs 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Birds (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

LU86958A 1987-07-31 1987-07-31 Sels d'acide thiamorpholinone carboxylique et de derives de diamino-2,4 pyrimidine,leur utilisation en cosmetique et pharmacie LU86958A1 (fr)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
LU86958A LU86958A1 (fr)	1987-07-31	1987-07-31	Sels d'acide thiamorpholinone carboxylique et de derives de diamino-2,4 pyrimidine,leur utilisation en cosmetique et pharmacie
EP88112024A EP0304649B1 (de)	1987-07-31	1988-07-26	Salze von 6-Piperidino-2,4-diaminopyrimidin-3-oxyd und von Derivaten der Thiamorpholin-3-on-5-carbonsäure und deren Verwendung in kosmetischen Stoffen und als Heilmittel
DE8888112024T DE3862083D1 (de)	1987-07-31	1988-07-26	Salze von 6-piperidino-2,4-diaminopyrimidin-3-oxyd und von derivaten der thiamorpholin-3-on-5-carbonsaeure und deren verwendung in kosmetischen stoffen und als heilmittel.
AT88112024T ATE61801T1 (de)	1987-07-31	1988-07-26	Salze von 6-piperidino-2,4-diaminopyrimidin-3oxyd und von derivaten der thiamorpholin-3-on-5- carbonsaeure und deren verwendung in kosmetischen stoffen und als heilmittel.
CA000573492A CA1314884C (fr)	1987-07-31	1988-07-29	Sels d'acide thiamorpholinone carboxylique et de derives de diamino-2,4 pyrimidine, leur utilisation en cosmetique et pharmacie
US07/225,818 US4970063A (en)	1987-07-31	1988-07-29	Salts of thiamorpholinone carboxylic acid with 2,4-diaminopyrimidine derivatives and their use in cosmetics and pharmaceuticals
JP63188534A JPS6450867A (en)	1987-07-31	1988-07-29	Salts of thiamorpholinonecarboxylic acid and 2,4-diaminopyrimidine derivative and use for cosmetic and pharmaceutical composition
GR91400638T GR3001965T3 (en)	1987-07-31	1991-05-20	Salts of 6-piperidino-2,4-diaminopyrimidin-3-oxide and of derivatives of thiamorpholin-3-on-5-carboxylic acid, their cosmetical and medicinal use

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
LU86958A LU86958A1 (fr)	1987-07-31	1987-07-31	Sels d'acide thiamorpholinone carboxylique et de derives de diamino-2,4 pyrimidine,leur utilisation en cosmetique et pharmacie
LU86958		1987-07-31

Publications (1)

Publication Number	Publication Date
LU86958A1 true LU86958A1 (fr)	1989-03-08

Family

ID=19730954

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU86958A LU86958A1 (fr)	1987-07-31	1987-07-31	Sels d'acide thiamorpholinone carboxylique et de derives de diamino-2,4 pyrimidine,leur utilisation en cosmetique et pharmacie

Country Status (8)

Country	Link
US (1)	US4970063A (de)
EP (1)	EP0304649B1 (de)
JP (1)	JPS6450867A (de)
AT (1)	ATE61801T1 (de)
CA (1)	CA1314884C (de)
DE (1)	DE3862083D1 (de)
GR (1)	GR3001965T3 (de)
LU (1)	LU86958A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU87304A1 (fr) *	1988-07-29	1990-02-07	Oreal	Nouveaux derives d'ureylene triamino-2,4,6 pyrimidine oxyde-3,leur preparation et leur utilisation en cosmetique et dermopharmacie
JP2869168B2 (ja) *	1990-08-10	1999-03-10	鐘紡株式会社	育毛剤及びそれを含有する養毛化粧料
AU690069B2 (en) *	1993-02-09	1998-04-23	Tulsa Forte Pharmacy Enterprises, Inc.	A method for stimulating hair growth with cationic derivatives of minoxidil using therapeutic iontophoresis
CN112811614A (zh) *	2020-12-03	2021-05-18	嘉兴沃特泰科环保科技股份有限公司	一种循环水无磷阻垢剂及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3382248A (en) *	1965-11-01	1968-05-07	Upjohn Co	6-amino-4, 5-di(substituted amino)-1, 2-dihydro-1-hydroxy-2-iminopyrimidines
US4139619A (en) *	1976-05-24	1979-02-13	The Upjohn Company	6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
HU177601B (en) *	1978-10-27	1981-11-28	Egyt Gyogyszervegyeszeti Gyar	New process for preparing 6-piperidino-2,4-diamino-pyrimidine-3-oxide
FR2525220A1 (fr) *	1982-04-15	1983-10-21	Oreal	Nouveaux derives substitues de la thiamorpholinone et leurs procedes de preparation
FR2525106B1 (fr) *	1982-04-15	1985-06-07	Oreal	Composition cosmetique contenant en tant qu'agent actif sur l'elasticite et la souplesse de la peau, de la thiamorpholinone ou l'un de ses derives
IT1201436B (it) *	1985-07-19	1989-02-02	Vincenzo Zappia	Formulazioni topiche a lento rilascio

1987
- 1987-07-31 LU LU86958A patent/LU86958A1/fr unknown
1988
- 1988-07-26 AT AT88112024T patent/ATE61801T1/de not_active IP Right Cessation
- 1988-07-26 DE DE8888112024T patent/DE3862083D1/de not_active Expired - Lifetime
- 1988-07-26 EP EP88112024A patent/EP0304649B1/de not_active Expired - Lifetime
- 1988-07-29 JP JP63188534A patent/JPS6450867A/ja active Pending
- 1988-07-29 CA CA000573492A patent/CA1314884C/fr not_active Expired - Fee Related
- 1988-07-29 US US07/225,818 patent/US4970063A/en not_active Expired - Fee Related
1991
- 1991-05-20 GR GR91400638T patent/GR3001965T3/el unknown

Also Published As

Publication number	Publication date
CA1314884C (fr)	1993-03-23
EP0304649B1 (de)	1991-03-20
EP0304649A1 (de)	1989-03-01
GR3001965T3 (en)	1992-11-23
ATE61801T1 (de)	1991-04-15
US4970063A (en)	1990-11-13
DE3862083D1 (de)	1991-04-25
JPS6450867A (en)	1989-02-27

Publication	Publication Date	Title
EP0540629B1 (de)	1994-05-04	Verwendung von pyrimidin-3-oxydderivaten zur verhütung von haarausfall und deren anwendung in topischen zusammensetzungen
EP0356271B1 (de)	1995-04-05	2,4-Diamino-pyrimidin-3-oxid-Derivate und deren Verwendung bei der Behandlung und zur Verhütung von Haarfall
CA1299572C (fr)	1992-04-28	Salicylates lipophiles d'ammoniums quaternaires, leur utilisation en cosmetique et en dermopharmacie
EP0420707B1 (de)	1993-12-15	2-Aminopyrimidin-3-oxid-Derivate enthaltende Zusammensetzungen zur Verwendung zum Vermindern des Haarausfalles und zum Induzieren und Stimulieren des Haarwuchses und neue von 2-Aminopyrimidin-3-oxid abgeleitete Verbindungen
EP0317846B1 (de)	1991-10-16	Pharmazeutische und kosmetische Zusammensetzungen auf der Basis von Benzoylperoxid und lipophilen quaternären Ammoniumsalizylaten und ihre Verwendung, insbesondere bei der Behandlung von Akne
EP0522964B1 (de)	2000-10-04	Zusammenstellungen, um den Haarausfall zu hemmen und um Haarwuchs zu induzieren und zu stimulieren auf Basis von 2,4-Diamino-pyrimidin-3-Oxydderivaten
EP0336812A2 (de)	1989-10-11	Assoziat, bestehend aus Pyrimidin-Derivaten und Harnstoff- und/oder Allantoin-Derivaten zum Induzieren und Stimulieren des Haarwuchses und zum Vermindern des Haarausfalles
BE1000320A3 (fr)	1988-10-18	Nouveaux derives de piperazinyl-1 pyrimidine, leur preparation et leur application en therapeutique et en cosmetique.
EP0408442B1 (de)	1994-08-31	Halogenierte Pyrimidin-3-oxid-Derivate, deren Verwendung für die Behandlung und die Verhütung von Haarausfall und für die Wachstumsförderung von Haaren
CA2251003C (fr)	2003-10-07	Nouveaux composes derives de n-aryl 2-hydroxy alkylamides
CA2006891C (fr)	2002-02-12	Composition pour induire et stimuler la croissance des cheveux et/ou freiner leur chute, a base de derives de pyrimidine et de filtres solaires
EP0321952B1 (de)	1992-08-19	Mischung, bestehend aus Pyrimidinderivaten und nichtsteroidalen entzündungshemmenden Mitteln zum Induzieren und Stimulieren des Haarwuchses und zum Vermindern des Haarausfalles
EP0886515B1 (de)	2002-01-16	Verwendung von n-aryl-2-hydroxyalkylamiden zur induzierung und/oder stimulation des haarwachstums und/oder zur verlangsamung des haarausfalls
LU86959A1 (fr)	1989-03-08	Nouveaux derives d'ureylene triamino-2,4,6 pyrimidine oxyde-3,leur preparation et leur utilisation en cosmetique et dermopharmacie
FR2753091A1 (fr)	1998-03-13	Utilisation d'un agoniste des recepteurs des retinoides de type rxr pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
LU87008A1 (fr)	1989-05-08	Nouveaux derives tertiobutyles du benzylidene camphre;leur procede de preparation,leur utilisation en tant qu'agents anti-oxydants et compositions cosmetiques et pharmaceutiques les contenant
LU86958A1 (fr)	1989-03-08	Sels d'acide thiamorpholinone carboxylique et de derives de diamino-2,4 pyrimidine,leur utilisation en cosmetique et pharmacie
EP0336813B1 (de)	1992-10-07	Assoziat bestehend aus Pyrimidin-Derivaten und Harnstoff- und/oder Allantoin-Derivaten zum Induzieren und Stimulieren des Haarwuchses und zum Vermindern des Haarausfalles
LU86865A1 (fr)	1989-01-19	Nouveaux retinoates d'ammonium quaternaires,leur utilisation en cosmetique et en dermopharmacie
LU85556A1 (fr)	1986-04-03	Nouveaux derives de l'acide retinoique,leur procede de preparation et compositions medicamenteuse et cosmetique les contenant
LU87323A1 (fr)	1990-03-13	Composition pour induire et stimuler la croissance des cheveux et/ou freiner leur chute,a base d'alkylpolyglycoside et d'un derive de pyrimidine
EP0915857B1 (de)	2002-07-17	Verbindungen aus der gruppe der 3-aryl-2,4-dioxo-oxazolidine und ihre verwendung in der kosmetik und pharmazie
CA2087591C (fr)	2006-05-23	Utilisation de derives de pyrimidine 3-oxyde pour freiner la chute des cheveux et compositions topiques mises en oeuvre
EP0427625B1 (de)	1995-01-04	Interne Salze des 2,4-Diamino-6-alkoxy-3-sulphooxypyrmidium-Hydroxids und ihre Verwendung für die Behandlung und die Verhütung des Haarausfalls
FR2657609A1 (fr)	1991-08-02	Nouveaux derives de pyrimidine oxyde-3 halogenes, leur utilisation pour le traitement et la prevention de la chute des cheveux et pour stimuler leur repousse.