LU88346I2 - Torasemide (Exhydran) - Google Patents

Torasemide (Exhydran)

Info

Publication number: LU88346I2
Authority: LU; Luxembourg
Prior art keywords: exhydran; torasemide
Prior art date: 1974-04-17

Application number

LU88346C

Other languages

English (en)

Original Assignee

Christiaens Sa A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-04-17

Filing date

1993-06-30

Publication date

1994-05-04

1993-06-30 Application filed by Christiaens Sa A filed Critical Christiaens Sa A

1994-05-04 Publication of LU88346I2 publication Critical patent/LU88346I2/fr

Links

NGBFQHCMQULJNZ-UHFFFAOYSA-N Torsemide Chemical compound CC(C)NC(=O)NS(=O)(=O)C1=CN=CC=C1NC1=CC=CC(C)=C1 NGBFQHCMQULJNZ-UHFFFAOYSA-N 0.000 title 1
229960005461 torasemide Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

LU88346C 1974-04-17 1993-06-30 Torasemide (Exhydran) LU88346I2 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB1683674A GB1477664A (en)	1974-04-17	1974-04-17	Pyridine derivatives
YU1507/81A YU42409B (en)	1974-04-17	1981-06-15	Process for obtaining new pyridine derivatives

Publications (1)

Publication Number	Publication Date
LU88346I2 true LU88346I2 (fr)	1994-05-04

Family

ID=26252269

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LU72284A LU72284A1 (fr)	1974-04-17	1975-04-15
LU88346C LU88346I2 (fr)	1974-04-17	1993-06-30	Torasemide (Exhydran)

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
LU72284A LU72284A1 (fr)	1974-04-17	1975-04-15

Country Status (19)

Country	Link
US (2)	US4018929A (fr)
JP (1)	JPS5951536B2 (fr)
AR (4)	AR211097A1 (fr)
AT (1)	AT344170B (fr)
BE (1)	BE827844A (fr)
CA (1)	CA1070313A (fr)
CH (3)	CH609045A5 (fr)
DD (2)	DD121936A5 (fr)
DE (1)	DE2516025A1 (fr)
ES (4)	ES436581A1 (fr)
FR (1)	FR2267775B1 (fr)
GB (1)	GB1477664A (fr)
HU (1)	HU171420B (fr)
IL (1)	IL47084A (fr)
LU (2)	LU72284A1 (fr)
NL (2)	NL183580C (fr)
SE (2)	SE424320B (fr)
YU (1)	YU42409B (fr)
ZA (1)	ZA752243B (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1593609A (en) *	1978-01-31	1981-07-22	Christiaens Sa A	Pyridine sulfonamides
US4776878A (en) *	1978-12-04	1988-10-11	E. I. Du Pont De Nemours And Company	Agricultural pyridinesulfonamides
LU85193A1 (fr) *	1984-01-31	1985-09-12	Christiaens Sa A	Nouveaux derives de la 4-phenylaminopyridine,leur utilisation et leur preparation
DE3529529A1 (de) *	1985-08-17	1987-02-19	Boehringer Mannheim Gmbh	Verfahren zur herstellung einer stabilen modifikation von torasemid
US4853389A (en) *	1987-07-24	1989-08-01	American Home Products Corporation	Diuretic and antihypertensive substituted-5-pyrimidinesulfonylureas
US4914203A (en) *	1987-07-24	1990-04-03	American Home Products Corporation	5 step process for preparing certain 2,4-diamino-5-pyrimidine-sulfonyl ureas
FR2659080B1 (fr) *	1990-03-02	1994-07-08	Adir	Nouveaux derives de la pyridylsulfonyluree et de la pyridylsulfonylthiouree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5166162A (en) *	1990-03-02	1992-11-24	Adir Et Compagnie	Pyridylsulfonylurea and pyridylsulfonylthiourea compounds
US5486530A (en) *	1991-04-27	1996-01-23	Boehringer Mannheim Gmbh	Use of torasemide for the treatment of brain oedemas
IT1288123B1 (it) *	1996-09-04	1998-09-10	Nicox Sa	Uso di nitroderivati per l'incontinenza urinaria
HRP980532B1 (en) *	1998-10-02	2005-06-30	Pliva	Novel crystalline torasemide modification
US6166045A (en) *	1998-06-02	2000-12-26	Roche Diagnostics Gmbh	Torasemide of modification III
US8008283B2 (en) *	1998-12-23	2011-08-30	Neurotherapeutics Pharma, Inc.	Methods and compositions for the treatment of neuropsychiatric disorders
US7214711B2 (en) *	1998-12-23	2007-05-08	Neurotherapeutics Pharma Llc	Method of treating migraine headache without aura
US8722668B2 (en) *	1998-12-23	2014-05-13	Daryl W. Hochman	Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders
WO2001010441A1 (fr) *	1999-08-11	2001-02-15	Teva Pharmaceutical Industries Ltd.	Polymorphes de torsemide
HUP0600143A2 (en) *	2000-02-17	2006-10-28	Teva Pharma	A stable pharmaceutical formulation comprising torsemide modification ii
HRP20000162B1 (en) *	2000-03-20	2004-06-30	Pliva D D	Amorphous torasemide modification
NZ521852A (en)	2000-03-20	2004-10-29	Teva Pharma	Novel processes for preparing torsemide intermediate
EP1741429A3 (fr) *	2000-03-20	2007-01-17	Teva Pharmaceutical Industries Ltd.	Procédé pour la préparation de torsemide
HRP20000328A2 (en) *	2000-05-19	2002-02-28	Pliva Farmaceutska Ind Dionik	Novel polymorph v of torasemide
US20030022921A1 (en) *	2001-02-21	2003-01-30	Minutza Leibovici	Stable pharmaceutical formulation comprising torsemide modification II
IN192178B (fr)	2001-08-03	2004-03-06	Ranbaxy Lab
IL149771A0 (en) *	2002-05-21	2002-11-10	Fintech Lab Ltd	Process for preparation of torsemide
HRP20020603B1 (en) *	2002-07-19	2008-11-30	Pliva D.D.	New process for the preparation of modification i n-(1-methylethylaminocarbonyl)-4-(3-methylphenylamino)-3-pyridinesulfonamide
CN1681495B (zh)	2002-08-19	2010-05-12	辉瑞产品公司	用于治疗过度增生性疾病的组合物
CA2401546C (fr) *	2002-09-06	2006-09-19	Brantford Chemicals Inc.	Synthese de derives de la 3-sulfonamido-4-phenylaminopyridine
ITMI20022749A1 (it) *	2002-12-23	2004-06-24	Cosma S P A	Nuovo procedimento per la sintesi della tosemide, in particolare della forma ii pura e stabile.
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
US20050215600A1 (en) *	2003-10-27	2005-09-29	Arie Gutman	Polymorphs of torsemide hydrochloride and process for production thereof
US7378527B2 (en) *	2004-03-16	2008-05-27	Daqing Che	Process for the preparation of torsemide and related intermediates
US20070149526A1 (en) *	2005-10-17	2007-06-28	Neurotherapeutics Pharma, L.L.C.	Diuretic and diuretic-like compound analogs
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
US7625896B2 (en) *	2005-11-25	2009-12-01	Hoffman-La Roche Inc.	Pyridylsulfonamide derivatives
US7939532B2 (en) *	2006-10-26	2011-05-10	Hoffmann-La Roche Inc.	Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
US8404896B2 (en)	2006-12-01	2013-03-26	Bristol-Myers Squibb Company	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2008138594A1 (fr) *	2007-05-16	2008-11-20	F. Hoffmann-La Roche Ag	Dérivés d'aryl pyridyl sulfonamide, leur fabrication et leur utilisation en tant qu'agents pharmaceutiques
NL2006622C2 (en)	2011-04-18	2012-10-22	Eurovet Animal Health B V	Use of a composition comprising torasemide.
EP2887806B1 (fr)	2012-07-20	2019-11-13	University Of Rochester	Méthode de traitement et de prévention d'une atteinte cérébrale faisant appel à des inhibiteurs de l'isoforme 1 du cotransporteur na+-k+ -2ci
BR112015026513A2 (pt)	2013-04-17	2017-07-25	Pfizer	derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
WO2016055901A1 (fr)	2014-10-08	2016-04-14	Pfizer Inc.	Composés d'amide substitué
MY193765A (en) *	2015-02-16	2022-10-27	Univ Queensland	Sulfonylureas and related compounds and use of same
HRP20220195T1 (hr)	2017-07-07	2022-04-15	Inflazome Limited	Novi spojevi sulfonamid karboksamida
RS66416B1 (sr)	2019-01-18	2025-02-28	Astrazeneca Ab	6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene
WO2021171230A1 (fr) *	2020-02-28	2021-09-02	Cadila Healthcare Limited	Nouveaux dérivés de sulfonylurées et de sulfoximineurées substitués

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3674794A (en) *	1970-03-18	1972-07-04	Ciba Geigy Corp	Certain-3-pyridine-sulfonamide derivatives
GB1368948A (en) *	1970-11-11	1974-10-02	Manuf Prod Pharma	Pyridine derivatives
GB1414793A (en) *	1972-07-28	1975-11-19	Manuf Prod Pharma	Derivatives of phenylaminopyridine
US3904636A (en) *	1971-11-09	1975-09-09	Christiaens Sa A	3-sulfonamido-4-phenyl aminopyridines and derivatives

1974
- 1974-04-17 GB GB1683674A patent/GB1477664A/en not_active Expired
1975
- 1975-04-08 ZA ZA00752243A patent/ZA752243B/xx unknown
- 1975-04-11 BE BE155330A patent/BE827844A/fr not_active IP Right Cessation
- 1975-04-12 DE DE19752516025 patent/DE2516025A1/de active Granted
- 1975-04-14 ES ES436581A patent/ES436581A1/es not_active Expired
- 1975-04-14 HU HU75CI00001569A patent/HU171420B/hu unknown
- 1975-04-14 IL IL47084A patent/IL47084A/xx unknown
- 1975-04-15 LU LU72284A patent/LU72284A1/xx unknown
- 1975-04-16 CH CH485775A patent/CH609045A5/xx not_active IP Right Cessation
- 1975-04-16 US US05/568,759 patent/US4018929A/en not_active Expired - Lifetime
- 1975-04-16 CA CA224,805A patent/CA1070313A/fr not_active Expired
- 1975-04-16 NL NLAANVRAGE7504521,A patent/NL183580C/xx active Protection Beyond IP Right Term
- 1975-04-16 CH CH216378A patent/CH610890A5/xx not_active IP Right Cessation
- 1975-04-16 FR FR7511791A patent/FR2267775B1/fr not_active Expired
- 1975-04-16 AT AT288275A patent/AT344170B/de not_active IP Right Cessation
- 1975-04-16 CH CH216478A patent/CH612424A5/xx not_active IP Right Cessation
- 1975-04-16 SE SE7504409A patent/SE424320B/xx unknown
- 1975-04-17 AR AR258409A patent/AR211097A1/es active
- 1975-04-17 DD DD185508A patent/DD121936A5/xx unknown
- 1975-04-17 JP JP50047371A patent/JPS5951536B2/ja not_active Expired
- 1975-04-17 DD DD194800A patent/DD126887A5/xx unknown
1976
- 1976-03-19 AR AR262627A patent/AR208770A1/es active
- 1976-03-19 AR AR262625A patent/AR208768A1/es active
- 1976-03-19 AR AR262626A patent/AR208769A1/es active
- 1976-11-15 ES ES453329A patent/ES453329A1/es not_active Expired
- 1976-11-15 ES ES453328A patent/ES453328A1/es not_active Expired
- 1976-11-15 ES ES453327A patent/ES453327A1/es not_active Expired
1979
- 1979-09-13 SE SE7907618A patent/SE7907618L/sv not_active Application Discontinuation
1980
- 1980-02-07 US US06/119,601 patent/USRE30633E/en not_active Expired - Lifetime
1981
- 1981-06-15 YU YU1507/81A patent/YU42409B/xx unknown
1993
- 1993-06-30 LU LU88346C patent/LU88346I2/fr unknown
1994
- 1994-07-27 NL NL940014C patent/NL940014I2/nl unknown

Also Published As

Publication number	Publication date
HU171420B (hu)	1978-01-28
CH610890A5 (fr)	1979-05-15
ES453328A1 (es)	1977-11-01
NL940014I2 (nl)	1997-04-01
JPS5951536B2 (ja)	1984-12-14
NL7504521A (nl)	1975-10-21
ES453327A1 (es)	1977-11-16
IL47084A (en)	1979-01-31
SE7504409L (sv)	1975-10-20
YU150781A (en)	1984-02-29
JPS50142571A (fr)	1975-11-17
IL47084A0 (en)	1975-06-25
CA1070313A (fr)	1980-01-22
SE424320B (sv)	1982-07-12
CH609045A5 (fr)	1979-02-15
BE827844A (fr)	1975-10-13
DD121936A5 (fr)	1976-09-05
YU42409B (en)	1988-08-31
CH612424A5 (fr)	1979-07-31
ES436581A1 (es)	1977-04-01
NL940014I1 (nl)	1994-09-16
AT344170B (de)	1978-07-10
DD126887A5 (fr)	1977-08-17
USRE30633E (en)	1981-06-02
AR208768A1 (es)	1977-02-28
AR208770A1 (es)	1977-02-28
SE7907618L (sv)	1979-09-13
AR208769A1 (es)	1977-02-28
US4018929A (en)	1977-04-19
NL183580B (nl)	1988-07-01
ATA288275A (de)	1977-11-15
ES453329A1 (es)	1977-11-16
LU72284A1 (fr)	1975-08-20
FR2267775A1 (fr)	1975-11-14
FR2267775B1 (fr)	1978-11-10
AU8001675A (en)	1976-10-14
DE2516025C2 (fr)	1988-11-03
DE2516025A1 (de)	1975-11-06
NL183580C (nl)	1988-12-01
AR211097A1 (es)	1977-10-31
GB1477664A (en)	1977-06-22
ZA752243B (en)	1976-03-31

Publication	Publication Date	Title
LU88346I2 (fr)	1994-05-04	Torasemide (Exhydran)
DK198075A (da)	1976-01-13	Planetgear
BE834318A (fr)	1976-04-08	Ophanginrichting
FI54981C (fi)	1979-04-10	Regleringssystem foer traktor
DK261175A (da)	1975-12-13	Ridesadel
DK577775A (da)	1976-06-20	Pigdek
AT338077B (de)	1977-07-25	Handmuhle
DK319075A (da)	1976-05-16	Parkometer
AT345679B (de)	1978-09-25	Kettenschloss
HU172312B (hu)	1978-07-28	Mekhanizm k litejnym ustrojstvam dlja vyvoda zhidkikh metallov
FI54847B (fi)	1978-12-29	Ransoneringsbehaollare foer djurutfodringsanordningar
DK281175A (da)	1975-12-22	Substituerede 0-acyl-acrylaldoximer
DK234275A (da)	1975-11-29	Harkroller
DK303375A (da)	1976-01-07	Skyderist
DK139405C (da)	1979-07-16	Klapankerrelae
BE824358R (fr)	1975-05-02	Phenolethanolamine acylff
AT342532B (de)	1978-04-10	Sparkerze
FI53479C (fi)	1978-05-10	Stomme foer vaeggelement
BE826873A (fr)	1975-09-19	Alkylsulfonylphenoxypropanolamines
BE825385A (fr)	1975-08-11	Elektrofotografisch filmdeel
JPS5173034A (ja)	1976-06-24	Tainetsuseisetsuchakuzaisoseibutsu
FI54848B (fi)	1978-12-29	Fiskekrok
DK203575A (da)	1975-11-23	Substituerede alfa-carboxyacetamid
DK138767B (da)	1978-10-23	Skyderist
JPS5158869A (ja)	1976-05-22	Bannaihandotaisoshinoreikyakuhoshiki