LU88750I2 - VENLAFAXINE et ses dérivés pharmaceutiquement acceptables - Google Patents

VENLAFAXINE et ses dérivés pharmaceutiquement acceptables

Info

Publication number
LU88750I2
LU88750I2 LU88750C LU88750C LU88750I2 LU 88750 I2 LU88750 I2 LU 88750I2 LU 88750 C LU88750 C LU 88750C LU 88750 C LU88750 C LU 88750C LU 88750 I2 LU88750 I2 LU 88750I2
Authority
LU
Luxembourg
Prior art keywords
venlafaxine
pharmaceutically acceptable
acceptable derivatives
derivatives
pharmaceutically
Prior art date
Application number
LU88750C
Other languages
English (en)
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838316646A external-priority patent/GB8316646D0/en
Priority claimed from US06/545,701 external-priority patent/US4535186A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of LU88750I2 publication Critical patent/LU88750I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/70—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
LU88750C 1982-12-13 1983-12-07 VENLAFAXINE et ses dérivés pharmaceutiquement acceptables LU88750I2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44903282A 1982-12-13 1982-12-13
US48659483A 1983-04-19 1983-04-19
GB838316646A GB8316646D0 (en) 1983-06-18 1983-06-18 Phenethylamine derivatives
US06/545,701 US4535186A (en) 1983-04-19 1983-10-26 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives

Publications (1)

Publication Number Publication Date
LU88750I2 true LU88750I2 (fr) 1996-08-23

Family

ID=27449489

Family Applications (1)

Application Number Title Priority Date Filing Date
LU88750C LU88750I2 (fr) 1982-12-13 1983-12-07 VENLAFAXINE et ses dérivés pharmaceutiquement acceptables

Country Status (7)

Country Link
EP (1) EP0112669B1 (fr)
AU (1) AU567524B2 (fr)
DE (2) DE3372753D1 (fr)
GB (2) GB2133788B (fr)
IE (1) IE56324B1 (fr)
LU (1) LU88750I2 (fr)
NL (1) NL940020I2 (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
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AU566673B2 (en) * 1983-09-15 1987-10-29 F. Hoffmann-La Roche Ag Phenethylamine derivatives
GB8501192D0 (en) * 1985-01-17 1985-02-20 Boots Co Plc Therapeutic agents
US4609758A (en) 1985-05-09 1986-09-02 American Home Products Corporation Phenoxyethylamine derivatives
GB8902209D0 (en) * 1989-02-01 1989-03-22 Wyeth John And Brother Limited Preparation of cyclohexanol derivatives and novel thioamide intermediates
US6440457B1 (en) 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
DK0639374T3 (da) * 1993-06-28 2002-05-06 American Home Prod Nye behandlingsmetoder ved anvendelse af phenethylderivater
TW344661B (en) * 1993-11-24 1998-11-11 Lilly Co Eli Pharmaceutical composition for treatment of incontinence
EP1331003B1 (fr) * 1996-03-25 2015-08-26 Wyeth LLC Composition de venlafaxine à libération prolongée
PE57198A1 (es) * 1996-03-25 1998-10-10 American Home Prod Formula de liberacion prolongada
US6197828B1 (en) 1998-12-01 2001-03-06 Sepracor, Inc. Derivatives of (+)-venlafaxine and methods of preparing and using the same
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
CA2368083A1 (fr) 1999-04-06 2000-10-12 Sepracor Inc. Derives de la venlafaxine et leurs procedes de preparation et utilisation
TWI228118B (en) * 2000-08-30 2005-02-21 Ciba Sc Holding Ag Process for the preparation of substituted phenylacetonitriles
CA2426393C (fr) 2000-10-31 2012-05-29 Ciba Specialty Chemicals Holding Inc. Formes cristallines de chlorhydrate de venlafaxine
WO2002046140A1 (fr) * 2000-12-07 2002-06-13 Dr. Reddy's Laboratories Ltd. Nouvelles formes polymorphes cristallines d'hydrochlorure de venlafaxine et procede permettant leur fabrication
EA011451B1 (ru) 2001-02-12 2009-04-28 Уайт Новая соль сукцинат о-десметилвенлафаксина
EP1238965B1 (fr) * 2001-02-28 2005-06-08 Council of Scientific and Industrial Research Procédé de préparation du 1-(2-diméthylamino-(4-méthoxyphényl)-éthyl)cyclohexanol
US6350912B1 (en) 2001-02-28 2002-02-26 Council Of Scientific And Industrial Research One pot process for the preparation of 1-[2-dimethylamino-(4-methoxyphenyl)-ethyl]cyclohexanol
EP1249447B1 (fr) 2001-04-10 2008-10-22 Alembic Limited Intermédiaire pour la production du 1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol
GB0126036D0 (en) * 2001-10-30 2001-12-19 Amedis Pharm Ltd Silicon compounds
DE10161818A1 (de) 2001-12-14 2003-06-26 Gruenenthal Gmbh Substituierte 1,5-Diaminopentan-3-ol-Verbindungen
WO2003103603A2 (fr) 2002-06-10 2003-12-18 Wyeth Nouveau sel de type formiate de o-desmethylvenlafaxine
WO2004094436A1 (fr) * 2003-04-24 2004-11-04 Amedis Pharmaceuticals Ltd. Derives de 1-(2-amino-1-phenyl-ethyl)-silacyclohexan-1-ol et utilisation desdits derives pour preparer un medicament
WO2005049560A2 (fr) * 2003-09-29 2005-06-02 Sun Pharmaceutical Industries Limited Procede de preparation d'un compose antidepresseur
TW200523258A (en) * 2003-10-02 2005-07-16 Wyeth Corp Process for the preparation of 1-[cyano(phenyl)methyl]-cyclohexanol compounds
DE10359154A1 (de) 2003-12-16 2005-07-28 Krka Tovarna Zdravil, D.D. Verfahren zur Herstellung von Venlafaxin und Venlafaxinhydrochlorid der Form I
JP2008546818A (ja) * 2005-06-29 2008-12-25 ワイエス １−［シアノ（４−ヒドロキシフェニル）メチル］シクロヘキサノール化合物の製造方法
CN101336226B (zh) * 2005-12-01 2012-05-23 奥斯拜客斯制药有限公司 具有5-羟色胺能活性和/或去甲肾上腺素能活性的取代的苯乙胺
EP2998288B1 (fr) 2005-12-01 2022-08-24 ACADIA Pharmaceuticals Inc. Phénétylamines substituées ayant une activité sérotoninergique et/ou norépinéphrinergique
WO2007071404A1 (fr) 2005-12-20 2007-06-28 Synthon B.V. Procédé de fabrication de la desvenlafaxine
WO2007094008A2 (fr) * 2006-02-16 2007-08-23 Unichem Laboratories Limited Nouveau procédé pour la préparation de chlorhydrate de venlafaxine et de ses intermédiaires
MX2007016179A (es) 2006-04-17 2008-03-11 Teva Pharma Formas cristalinas de o-desmetilvenlafaxina.
JP4763788B2 (ja) * 2006-07-26 2011-08-31 テバ ファーマシューティカル インダストリーズ リミティド Ｏ−デスメチルベンラファキシンの合成方法
US20080183016A1 (en) 2006-07-26 2008-07-31 Valerie Niddam-Hildesheim Process for the synthesis of O-desmethylvenlafaxine
FR2909089B1 (fr) 2006-11-23 2009-02-27 Ppg Sipsy Soc Par Actions Simp Procede in situ ou "one pot" d'hydrogenation et d'amination reductrice
AR064987A1 (es) * 2007-01-22 2009-05-06 Medichem Sa Proceso mejorado para sintetizar desvenlafaxina como base libre y sales o solvatos de la misma
AU2008211711A1 (en) * 2007-01-31 2008-08-07 Generics [Uk] Limited Process for the preparation of O-desmethyl venlafaxine
CA2680912C (fr) 2007-03-15 2017-11-14 Auspex Pharmaceuticals, Inc. Phenethylamines substituees a action serotoninergique et/ou norepinephrinergique
WO2009017813A1 (fr) * 2007-08-02 2009-02-05 Teva Pharmaceutical Industries Ltd. Saccharinate d'o-desméthyl-venlafaxine
US20110046231A1 (en) * 2007-10-22 2011-02-24 Actavis Group Ptc Ehf Solid forms of (±)-o-desmethylvenlafaxine salts
KR101343027B1 (ko) 2007-11-26 2013-12-18 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신 푸마레이트의 결정형
EP2085377A1 (fr) 2008-01-29 2009-08-05 LEK Pharmaceuticals D.D. Nouveaux sels d'O-desméthyl-venlafaxine
EP2252573A2 (fr) * 2008-02-14 2010-11-24 Egis Gyógyszergyár Nyilvánosan Müködö Nouvelles formes polymorphes et amorphes du fumarate de desvenlafaxine
WO2009128057A2 (fr) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Produits psycho-pharmaceutiques
EP2119695A1 (fr) 2008-05-16 2009-11-18 Krka Préparation de sels de O-desméthylvenlafaxine
EP2119696A1 (fr) 2008-05-16 2009-11-18 Krka Préparation de sels de O-desméthylvenlafaxine
CZ301503B6 (cs) * 2008-11-27 2010-03-24 Zentiva, A. S. Zpusob prípravy desvenlafaxinu a jeho solí
CZ2009454A3 (cs) * 2009-07-15 2010-11-10 Zentiva, K. S. Zpusob prípravy desvenlafaxinu a jeho solí
EP2513041A1 (fr) 2009-12-16 2012-10-24 Pharmathen S.A. Procédé de préparation d'o-desméthyl-venlafaxine et ses sels
CA2795023A1 (fr) 2010-03-29 2011-10-06 Pliva Hrvatska D.O.O. Formes cristallines du fumarate de o-desmethylvenlafaxine
EP2746264A1 (fr) 2012-12-19 2014-06-25 Basf Se [1,2,4]triazole substitué et composés d'imidazole
EP2746255A1 (fr) 2012-12-19 2014-06-25 Basf Se Composés de [1,2,4]triazole et d'imidazole substitués
US9527800B2 (en) 2013-10-29 2016-12-27 Council Of Scientific And Industrial Research Process for total synthesis of venlafaxine
CN104529797A (zh) * 2014-12-05 2015-04-22 南昌市博泽康医药科技有限公司 盐酸文拉法辛手性晶型的制备

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1124485B (de) * 1960-02-12 1962-03-01 Hoechst Ag Verfahren zur Herstellung von analeptisch wirksamen Phenylcycloalkylmethylaminen
GB1098835A (en) * 1965-07-13 1968-01-10 Jacques Logeais Sa Lab Spiro-oxazolidinones, spiro-oxazines, their process of preparation and therapeutic compositions containing said derivatives
JPS56113748A (en) * 1980-02-13 1981-09-07 Kowa Co Aminoethanol derivative and its preparation

Also Published As

Publication number Publication date
EP0112669A3 (en) 1984-11-28
NL940020I1 (nl) 1994-12-16
AU2212383A (en) 1984-06-21
GB8603901D0 (en) 1986-03-26
GB2133788A (en) 1984-08-01
GB8332598D0 (en) 1984-01-11
EP0112669A2 (fr) 1984-07-04
IE832818L (en) 1984-06-13
DE19675025I2 (de) 2003-05-22
IE56324B1 (en) 1991-06-19
AU567524B2 (en) 1987-11-26
NL940020I2 (nl) 1999-07-01
DE3372753D1 (en) 1987-09-03
GB2173787A (en) 1986-10-22
GB2133788B (en) 1987-07-15
EP0112669B1 (fr) 1987-07-29
GB2173787B (en) 1987-07-15

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