LU90340I2 - Composition pharmaceutique stable d'ester de phosphate de disodium de 3-(hydroxymethyl)-5,5-diphenylhydantoiene - Google Patents

Composition pharmaceutique stable d'ester de phosphate de disodium de 3-(hydroxymethyl)-5,5-diphenylhydantoiene

Info

Publication number
LU90340I2
LU90340I2 LU90340C LU90340C LU90340I2 LU 90340 I2 LU90340 I2 LU 90340I2 LU 90340 C LU90340 C LU 90340C LU 90340 C LU90340 C LU 90340C LU 90340 I2 LU90340 I2 LU 90340I2
Authority
LU
Luxembourg
Prior art keywords
hydroxymethyl
pharmaceutical composition
phosphate ester
disodium phosphate
stable
Prior art date
Application number
LU90340C
Other languages
English (en)
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of LU90340I2 publication Critical patent/LU90340I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Dental Preparations (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LU90340C 1989-05-25 1999-01-19 Composition pharmaceutique stable d'ester de phosphate de disodium de 3-(hydroxymethyl)-5,5-diphenylhydantoiene LU90340I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/356,948 US4925860A (en) 1987-08-05 1989-05-25 Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester
PCT/US1990/002733 WO1990014080A1 (fr) 1989-05-25 1990-05-24 Composition pharmaceutique stable d'ester de phosphate de disodium de 3-(hydroxymethyl)-5,5-diphenylhydantoïne

Publications (1)

Publication Number Publication Date
LU90340I2 true LU90340I2 (fr) 1999-03-19

Family

ID=23403641

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90340C LU90340I2 (fr) 1989-05-25 1999-01-19 Composition pharmaceutique stable d'ester de phosphate de disodium de 3-(hydroxymethyl)-5,5-diphenylhydantoiene

Country Status (27)

Country Link
US (1) US4925860A (fr)
EP (1) EP0473687B1 (fr)
JP (1) JP3143471B2 (fr)
KR (1) KR0143768B1 (fr)
AT (1) ATE135907T1 (fr)
AU (1) AU632130B2 (fr)
CA (1) CA2067122A1 (fr)
CZ (1) CZ277918B6 (fr)
DE (2) DE69026253T2 (fr)
DK (1) DK0473687T3 (fr)
ES (1) ES2086404T3 (fr)
FI (1) FI101041B (fr)
HU (1) HU212944B (fr)
IE (1) IE81130B1 (fr)
IL (1) IL94504A (fr)
LU (1) LU90340I2 (fr)
MX (1) MX9203584A (fr)
MY (1) MY106190A (fr)
NL (1) NL980045I2 (fr)
NO (1) NO179124C (fr)
NZ (1) NZ233808A (fr)
PT (1) PT94161B (fr)
RU (1) RU2075973C1 (fr)
SG (1) SG64881A1 (fr)
SK (1) SK277911B6 (fr)
WO (1) WO1990014080A1 (fr)
ZA (1) ZA904038B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU624262B2 (en) * 1989-08-10 1992-06-04 Warner-Lambert Company Use of prophenytoin for treating stroke
SI0900227T1 (en) 1996-04-30 2002-04-30 Warner-Lambert Company Improved process for the synthesis of diesters of phosphoric acid 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethyl ester
US6133248A (en) * 1997-06-13 2000-10-17 Cydex, Inc. Polar drug of prodrug compositions with extended shelf-life storage and a method of making thereof
AU8479998A (en) * 1997-07-22 1999-02-16 Warner-Lambert Company Lyophilized fosphenytoin sodium for parenteral use
US6110499A (en) * 1997-07-24 2000-08-29 Alza Corporation Phenytoin therapy
AU2985100A (en) 1999-02-08 2000-08-25 Checkpoint Genetics, Inc. (n)-substituted amino acids, antioxidant pharmaceutical compositions containing same and methods using same
AU5824800A (en) * 1999-06-23 2001-01-31 Warner-Lambert Company Use of fosphenytoin for the treatment of acute neuropathic pain
US20060034910A1 (en) * 2004-08-09 2006-02-16 Sanjay Patel Pharmaceutical composition for extended release of phenytoin sodium
US20070244074A1 (en) * 2006-04-17 2007-10-18 Sougata Pramanick Stable parenteral formulation of fosphenytoin sodium
KR101303088B1 (ko) * 2009-02-17 2013-09-06 한림제약(주) 3-(히드록시메틸)-5,5-디페닐히단토인 이나트륨 포스페이트에스테르를 함유하는 주사용 약학 조성물
CA2937222C (fr) 2009-06-25 2019-06-04 Alkermes Pharma Ireland Limited Promedicaments de composes nh acides
US8431576B2 (en) 2009-06-25 2013-04-30 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
ES2691671T3 (es) 2010-06-24 2018-11-28 Alkermes Pharma Ireland Limited Profármacos de compuestos NH-acídicos: derivados de éster, carbonato, carbamato y fosfonato
HUE065359T2 (hu) 2011-03-18 2024-05-28 Alkermes Pharma Ireland Ltd Szorbitán-észtereket tartalmazó gyógyászati készítmények
UY34072A (es) 2011-05-17 2013-01-03 Novartis Ag Derivados sustituidos de indol
JP5952912B2 (ja) 2011-12-15 2016-07-13 アルカーメス ファーマ アイルランド リミテッド 二級アミン化合物のプロドラッグ
JP6219918B2 (ja) 2012-03-19 2017-10-25 アルカームス ファーマ アイルランド リミテッド グリセロールエステルを含む医薬組成物
ES2765036T3 (es) 2012-03-19 2020-06-05 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden esteres de ácidos grasos
ES2950418T3 (es) 2012-03-19 2023-10-09 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden alcohol bencílico
EP2897592B1 (fr) 2012-09-19 2020-02-19 Alkermes Pharma Ireland Limited Compositions pharmaceutiques ayant une plus grande stabilité au stockage
CN103288877B (zh) * 2013-05-10 2016-03-09 安徽省先锋制药有限公司 磷苯妥英稳定的有机胺盐及其制备方法和用途
BR112016021535A8 (pt) 2014-03-20 2021-07-20 Alkermes Pharma Ireland Ltd kit compreendendo formulações de aripiprazol tendo velocidades de injeção aumentadas útil para o tratamento de uma desordem do sistema nervoso central e uso
EP3761983A1 (fr) 2018-03-05 2021-01-13 Alkermes Pharma Ireland Limited Stratégie de dosage d'aripiprazole
AU2020480182B2 (en) 2020-12-04 2025-02-27 Sichuan Credit Pharmaceutical Co., Ltd Fosphenytoin sodium solid composition, lyophilization method, and use of fosphenytoin sodium solid composition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260769A (en) * 1977-04-22 1981-04-07 Interx Research Corporation 5,5-Diphenylhydantoins

Also Published As

Publication number Publication date
ATE135907T1 (de) 1996-04-15
IL94504A0 (en) 1991-03-10
HU212944B (en) 1996-12-30
NO179124C (no) 1996-08-14
NZ233808A (en) 1992-04-28
ZA904038B (en) 1992-01-29
ES2086404T3 (es) 1996-07-01
RU2075973C1 (ru) 1997-03-27
IE901872L (en) 1990-11-25
SG64881A1 (en) 1999-11-16
CZ277918B6 (en) 1993-06-16
NO179124B (no) 1996-05-06
MX9203584A (es) 1992-07-01
WO1990014080A1 (fr) 1990-11-29
DE19975021I2 (de) 2004-07-01
AU5670490A (en) 1990-12-18
DE69026253D1 (en) 1996-05-02
SK277911B6 (en) 1995-07-11
NL980045I1 (nl) 1999-03-01
HUT61198A (en) 1992-12-28
HK1006807A1 (en) 1999-03-19
CS9002566A2 (en) 1991-10-15
AU632130B2 (en) 1992-12-17
NL980045I2 (nl) 1999-07-01
IE81130B1 (en) 2000-03-22
NO914582D0 (no) 1991-11-22
DK0473687T3 (da) 1996-08-05
EP0473687B1 (fr) 1996-03-27
CA2067122A1 (fr) 1990-11-26
FI101041B (fi) 1998-04-15
EP0473687A4 (en) 1992-12-02
KR0143768B1 (ko) 1998-07-15
FI915491A0 (fi) 1991-11-21
PT94161B (pt) 1996-12-31
JP3143471B2 (ja) 2001-03-07
EP0473687A1 (fr) 1992-03-11
NO914582L (no) 1991-11-22
IL94504A (en) 1994-06-24
JPH05504544A (ja) 1993-07-15
KR920700628A (ko) 1992-08-10
DE69026253T2 (de) 1996-09-19
PT94161A (pt) 1991-01-08
MY106190A (en) 1995-03-31
US4925860A (en) 1990-05-15

Similar Documents

Publication Publication Date Title
LU90340I2 (fr) Composition pharmaceutique stable d'ester de phosphate de disodium de 3-(hydroxymethyl)-5,5-diphenylhydantoiene
DE3582033D1 (de) Pharmazeutische zusammensetzungen, die geminale diphosphonate enthalten.
PT99597B (pt) Processo para a preparacao de derivados do acido hidroxamico que inibem a lipoxigenase
ATE121295T1 (de) Augentropfenarzneimittel.
NO179671C (no) Substituerte cykloheksanderivater, anvendelse av disse for fremstilling av legemidler samt legemiddel for behandling type II diabetes og andre sykdommer
DZ854A1 (fr) Procédé continu de préparation d'acide phosphorique et de sulfate de calcium.
ATE173401T1 (de) Neue verwendung von 1-alpha-hydroxylierten-19-nor-vitamin-d-verbind ngen zur behandlung von psoriasis
ATE147265T1 (de) Verwendung von retinoiden zur umkehr glucocorticoid-induzierter hautatrophie
SE9300758L (sv) Förfarande för framställning av kavulansyrasalter
BE893492A (fr) Procede de preparation d'esters d'acides apovincaminiques, esters ainsi obtenus et compositions pharmaceutiques prepares avec ces esters
HUT70757A (en) Pharmaceutical compositions for treating skin disorders
BR9304151A (pt) Soluçao de injeçao da mesma, processo para sua produçao, aplicaçao dessa coluçâo e produto farmaceutico para evitar o efeito colateral de oxazafosforina
GR1001133B (el) Μέ?οδος παρασκευής στα?ερής σύν?εσης δινατρίου άλατος φωσφορικού εστέρος 3-(υδροξυμε?υλο)-5,5-διφαινυλουδαντοϊνης.
NO914005D0 (no) Fremgangsmaate for fremstilling av vitamin d2-forbindelserog de tilsvarende alfa-hydroksylerte derivater
ES2059879T3 (es) Compuestos sn-198c fisiologicamente activos y metodo y bacterias para su produccion.
FR2689128B1 (fr) Procede de preparation de l'acide alpha-methyl 5-benzoyl 2-thiophene acetique optiquement actif et intermediaires.
AU1753188A (en) Treating agents for renal diseases