ATE135907T1 - Stabile arzneimittel mit 3-(hydroxymethyl)-5,5- diphenylhydantoin-dinatrium-phosphatester - Google Patents

Stabile arzneimittel mit 3-(hydroxymethyl)-5,5- diphenylhydantoin-dinatrium-phosphatester

Info

Publication number: ATE135907T1
Authority: AT; Austria
Prior art keywords: diphenylhydantoin; hydroxymethyl; dinatrium; phenytoin; phosphate esters
Prior art date: 1989-05-25

Application number

AT90908752T

Other languages

English (en)

Inventor

Dale E Herbranson

Earl R Speicher

Leonard S Rosenberg

Original Assignee

Du Pont Merck Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-25

Filing date

1990-05-24

Publication date

1996-04-15

1990-05-24 Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma

1996-04-15 Application granted granted Critical

1996-04-15 Publication of ATE135907T1 publication Critical patent/ATE135907T1/de

Links

FELMSRDKUFGXSF-UHFFFAOYSA-L [Na+].[Na+].P(=O)([O-])([O-])O.OCN1C(NC(C1=O)(C1=CC=CC=C1)C1=CC=CC=C1)=O Chemical class [Na+].[Na+].P(=O)([O-])([O-])O.OCN1C(NC(C1=O)(C1=CC=CC=C1)C1=CC=CC=C1)=O FELMSRDKUFGXSF-UHFFFAOYSA-L 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 abstract 3
230000015556 catabolic process Effects 0.000 abstract 3
238000006731 degradation reaction Methods 0.000 abstract 3
229960002036 phenytoin Drugs 0.000 abstract 2
229940002612 prodrug Drugs 0.000 abstract 2
239000000651 prodrug Substances 0.000 abstract 2
MUTSJHVOFFHGGL-UHFFFAOYSA-N 2-(n-phenylanilino)acetamide Chemical compound C=1C=CC=CC=1N(CC(=O)N)C1=CC=CC=C1 MUTSJHVOFFHGGL-UHFFFAOYSA-N 0.000 abstract 1
230000002920 convulsive effect Effects 0.000 abstract 1
239000008380 degradant Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Adhesives Or Adhesive Processes (AREA)
Dental Preparations (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT90908752T 1989-05-25 1990-05-24 Stabile arzneimittel mit 3-(hydroxymethyl)-5,5- diphenylhydantoin-dinatrium-phosphatester ATE135907T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/356,948 US4925860A (en)	1987-08-05	1989-05-25	Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester

Publications (1)

Publication Number	Publication Date
ATE135907T1 true ATE135907T1 (de)	1996-04-15

Family

ID=23403641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90908752T ATE135907T1 (de)	1989-05-25	1990-05-24	Stabile arzneimittel mit 3-(hydroxymethyl)-5,5- diphenylhydantoin-dinatrium-phosphatester

Country Status (28)

Country	Link
US (1)	US4925860A (de)
EP (1)	EP0473687B1 (de)
JP (1)	JP3143471B2 (de)
KR (1)	KR0143768B1 (de)
AT (1)	ATE135907T1 (de)
AU (1)	AU632130B2 (de)
CA (1)	CA2067122A1 (de)
CZ (1)	CZ277918B6 (de)
DE (2)	DE69026253T2 (de)
DK (1)	DK0473687T3 (de)
ES (1)	ES2086404T3 (de)
FI (1)	FI101041B (de)
HK (1)	HK1006807A1 (de)
HU (1)	HU212944B (de)
IE (1)	IE81130B1 (de)
IL (1)	IL94504A (de)
LU (1)	LU90340I2 (de)
MX (1)	MX9203584A (de)
MY (1)	MY106190A (de)
NL (1)	NL980045I2 (de)
NO (1)	NO179124C (de)
NZ (1)	NZ233808A (de)
PT (1)	PT94161B (de)
RU (1)	RU2075973C1 (de)
SG (1)	SG64881A1 (de)
SK (1)	SK277911B6 (de)
WO (1)	WO1990014080A1 (de)
ZA (1)	ZA904038B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU624262B2 (en) *	1989-08-10	1992-06-04	Warner-Lambert Company	Use of prophenytoin for treating stroke
ES2169375T3 (es) *	1996-04-30	2002-07-01	Warner Lambert Co	Proceso mejorado para la sintesis de diesteres del ester 2,5-dioxo-4,4-difenil-imidazolidin-1-ilmetilico de acido fosforico.
WO1998056422A1 (en) *	1997-06-13	1998-12-17	The University Of Kansas	Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof
WO1999004798A1 (en) *	1997-07-22	1999-02-04	Warner-Lambert Company	Lyophilized fosphenytoin sodium for parenteral use
US6110499A (en) *	1997-07-24	2000-08-29	Alza Corporation	Phenytoin therapy
EP1153010A1 (de)	1999-02-08	2001-11-14	Checkpoint Genetics, Inc.	N-substituierte aminosäuren, pharmazeutische antioxidant-zusammensetzungen die diese enthalten und verfahren zu ihrer anwendung
WO2001000191A2 (en) *	1999-06-23	2001-01-04	Warner-Lambert Company	Use of fosphenytion for the treatment of acute neuropathic pain
US20060034910A1 (en) *	2004-08-09	2006-02-16	Sanjay Patel	Pharmaceutical composition for extended release of phenytoin sodium
US20070244074A1 (en) *	2006-04-17	2007-10-18	Sougata Pramanick	Stable parenteral formulation of fosphenytoin sodium
KR101303088B1 (ko) *	2009-02-17	2013-09-06	한림제약(주)	3-(히드록시메틸)-5,5-디페닐히단토인 이나트륨 포스페이트에스테르를 함유하는 주사용 약학 조성물
ES3031438T3 (en)	2009-06-25	2025-07-08	Alkermes Pharma Ireland Ltd	Heterocyclic compounds for the treatment of neurological and psychological disorders
CA2937222C (en)	2009-06-25	2019-06-04	Alkermes Pharma Ireland Limited	Prodrugs of nh-acidic compounds
WO2011163594A2 (en)	2010-06-24	2011-12-29	Alkermes, Inc.	Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
US9034867B2 (en)	2011-03-18	2015-05-19	Alkermes Pharma Ireland Limited	Pharmaceutical compositions comprising sorbitan esters
UY34072A (es)	2011-05-17	2013-01-03	Novartis Ag	Derivados sustituidos de indol
WO2013088255A1 (en)	2011-12-15	2013-06-20	Alkermes Pharma Ireland Limited	Prodrugs of secondary amine compounds
WO2013142198A1 (en)	2012-03-19	2013-09-26	Alkermes Pharma Ireland Limited	Pharmaaceutical compositions comprising fatty acid esters
WO2013142205A1 (en)	2012-03-19	2013-09-26	Alkermes Pharma Ireland Limited	Pharmaceutical compositions comprising benzyl alcohol
JP6219918B2 (ja)	2012-03-19	2017-10-25	アルカームスファーマアイルランドリミテッド	グリセロールエステルを含む医薬組成物
EP3718536A1 (de)	2012-09-19	2020-10-07	Alkermes Pharma Ireland Limited	Pharmazeutische zusammensetzungen mit verbesserter lagerstabilität
CN103288877B (zh) *	2013-05-10	2016-03-09	安徽省先锋制药有限公司	磷苯妥英稳定的有机胺盐及其制备方法和用途
EP3119399A4 (de)	2014-03-20	2017-09-27	Alkermes Pharma Ireland Limited	Aripiprazolformulierungen mit erhöhten injektionsgeschwindigkeiten
CA3092335A1 (en)	2018-03-05	2019-09-12	Alkermes Pharma Ireland Limited	Aripiprazole dosing strategy
JP7720391B2 (ja)	2020-12-04	2025-08-07	シーチュアンクレジットファーマシューティカルカンパニーリミテッド	フォスフェニトインナトリウム固体組成物、凍結乾燥法、及びその使用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4260769A (en) *	1977-04-22	1981-04-07	Interx Research Corporation	5,5-Diphenylhydantoins

1989
- 1989-05-25 US US07/356,948 patent/US4925860A/en not_active Expired - Lifetime
1990
- 1990-05-24 IE IE187290A patent/IE81130B1/en not_active IP Right Cessation
- 1990-05-24 RU SU905010404A patent/RU2075973C1/ru active
- 1990-05-24 ES ES90908752T patent/ES2086404T3/es not_active Expired - Lifetime
- 1990-05-24 KR KR1019910701660A patent/KR0143768B1/ko not_active Expired - Lifetime
- 1990-05-24 HU HU905265A patent/HU212944B/hu unknown
- 1990-05-24 MY MYPI90000848A patent/MY106190A/en unknown
- 1990-05-24 EP EP90908752A patent/EP0473687B1/de not_active Expired - Lifetime
- 1990-05-24 HK HK98105498A patent/HK1006807A1/en not_active IP Right Cessation
- 1990-05-24 CA CA002067122A patent/CA2067122A1/en not_active Abandoned
- 1990-05-24 DK DK90908752.0T patent/DK0473687T3/da active
- 1990-05-24 JP JP02508239A patent/JP3143471B2/ja not_active Expired - Lifetime
- 1990-05-24 WO PCT/US1990/002733 patent/WO1990014080A1/en not_active Ceased
- 1990-05-24 NZ NZ233808A patent/NZ233808A/en unknown
- 1990-05-24 DE DE69026253T patent/DE69026253T2/de not_active Expired - Lifetime
- 1990-05-24 SG SG1996003778A patent/SG64881A1/en unknown
- 1990-05-24 AU AU56704/90A patent/AU632130B2/en not_active Expired
- 1990-05-24 DE DE1999175021 patent/DE19975021I2/de active Active
- 1990-05-24 AT AT90908752T patent/ATE135907T1/de active
- 1990-05-25 SK SK2566-90A patent/SK277911B6/sk not_active IP Right Cessation
- 1990-05-25 PT PT94161A patent/PT94161B/pt not_active IP Right Cessation
- 1990-05-25 CZ CS902566A patent/CZ277918B6/cs not_active IP Right Cessation
- 1990-05-25 ZA ZA904038A patent/ZA904038B/xx unknown
- 1990-05-25 IL IL9450490A patent/IL94504A/en not_active IP Right Cessation
1991
- 1991-11-21 FI FI915491A patent/FI101041B/fi active Protection Beyond IP Right Term
- 1991-11-22 NO NO914582A patent/NO179124C/no not_active IP Right Cessation
1992
- 1992-06-26 MX MX9203584A patent/MX9203584A/es active IP Right Grant
1998
- 1998-12-24 NL NL980045C patent/NL980045I2/nl unknown
1999
- 1999-01-19 LU LU90340C patent/LU90340I2/fr unknown

Also Published As

Publication number	Publication date
EP0473687A4 (en)	1992-12-02
SK277911B6 (en)	1995-07-11
CZ277918B6 (en)	1993-06-16
NO179124B (no)	1996-05-06
RU2075973C1 (ru)	1997-03-27
NO914582D0 (no)	1991-11-22
HUT61198A (en)	1992-12-28
NL980045I2 (nl)	1999-07-01
WO1990014080A1 (en)	1990-11-29
CA2067122A1 (en)	1990-11-26
DE19975021I2 (de)	2004-07-01
HK1006807A1 (en)	1999-03-19
DE69026253T2 (de)	1996-09-19
NO179124C (no)	1996-08-14
MX9203584A (es)	1992-07-01
SG64881A1 (en)	1999-11-16
EP0473687B1 (de)	1996-03-27
NO914582L (no)	1991-11-22
JP3143471B2 (ja)	2001-03-07
ES2086404T3 (es)	1996-07-01
KR920700628A (ko)	1992-08-10
CS9002566A2 (en)	1991-10-15
IE81130B1 (en)	2000-03-22
KR0143768B1 (ko)	1998-07-15
PT94161A (pt)	1991-01-08
NZ233808A (en)	1992-04-28
HU212944B (en)	1996-12-30
IL94504A (en)	1994-06-24
LU90340I2 (fr)	1999-03-19
IL94504A0 (en)	1991-03-10
AU5670490A (en)	1990-12-18
MY106190A (en)	1995-03-31
ZA904038B (en)	1992-01-29
PT94161B (pt)	1996-12-31
FI101041B (fi)	1998-04-15
FI915491A0 (fi)	1991-11-21
JPH05504544A (ja)	1993-07-15
DE69026253D1 (en)	1996-05-02
IE901872L (en)	1990-11-25
DK0473687T3 (da)	1996-08-05
EP0473687A1 (de)	1992-03-11
NL980045I1 (nl)	1999-03-01
AU632130B2 (en)	1992-12-17
US4925860A (en)	1990-05-15

Publication	Publication Date	Title
DE19975021I2 (de)	2004-07-01	Stabile Arzneimittel mit 3-(hydroxymethyl)-5,5-diphenylhydantoin-dinatrium-phosphatester.
ES2122076T3 (es)	1998-12-16	Derivados de nor-acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos.
GB8819110D0 (en)	1988-09-14	Antihypertensive drug & method for production
IT1276225B1 (it)	1997-10-27	Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
ATE121295T1 (de)	1995-05-15	Augentropfenarzneimittel.
NO179671C (no)	1996-11-27	Substituerte cykloheksanderivater, anvendelse av disse for fremstilling av legemidler samt legemiddel for behandling type II diabetes og andre sykdommer
ATE147265T1 (de)	1997-01-15	Verwendung von retinoiden zur umkehr glucocorticoid-induzierter hautatrophie
NO303715B1 (no)	1998-08-24	Stabilt, vandig apparat
NO301767B1 (no)	1997-12-08	Salt av clavulansyre
BE893492A (fr)	1982-12-13	Procede de preparation d'esters d'acides apovincaminiques, esters ainsi obtenus et compositions pharmaceutiques prepares avec ces esters
ATE179889T1 (de)	1999-05-15	Arzneimittel, die ester omega-3 polyungesättigter säuren enthalten und deren verwendung in der topischen behandlung morbider erkrankungen
ATE183088T1 (de)	1999-08-15	Arzneimittel zur behandlung von hauterkrankungen
BR9304151A (pt)	1994-06-07	Soluçao de injeçao da mesma, processo para sua produçao, aplicaçao dessa coluçâo e produto farmaceutico para evitar o efeito colateral de oxazafosforina
BR0013563A (pt)	2002-07-09	Preparação farmacêutica sólida, utilização de uma preparação farmacêutica e processo para a produção de uma preparação farmacêutica
GR1001133B (el)	1993-04-28	Μέ?οδος παρασκευής στα?ερής σύν?εσης δινατρίου άλατος φωσφορικού εστέρος 3-(υδροξυμε?υλο)-5,5-διφαινυλουδαντοϊνης.
IT1244728B (it)	1994-08-08	Impiego medicamentoso di derivati diidropiridinici
ITMI940696A0 (it)	1994-04-14	Derivati dell'acido fosfonico utili nel trattamento delle malattie cardiovascolari
ITMI911842A0 (it)	1991-07-04	Derivati dell'eseridina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
ITMI912027A0 (it)	1991-07-23	Derivati dell'eserolina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
ITMI911841A0 (it)	1991-07-04	Derivati dell'eseridina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
ITMI911713A0 (it)	1991-06-21	Derivati dell'eseridina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1263913B (it)	1996-09-05	Composti terapeuticamente attivi, utili per il trattamento di malattieconnesse con alterata funzionalita' del sistema immunitario, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
BR9204459A (pt)	1993-05-25	Derivados de aminoacidos e processo para a sua producao,compostos,medicamentos,uso dos ditos derivados e processo para tratar ou prevenir pressao sanguinea elevada e/ou insuficiencia cardlaca