LU90717I2 - Complexe citrate-doxorubicine encapsul- dans des liposomes - Google Patents

Complexe citrate-doxorubicine encapsul- dans des liposomes

Info

Publication number
LU90717I2
LU90717I2 LU90717C LU90717C LU90717I2 LU 90717 I2 LU90717 I2 LU 90717I2 LU 90717 C LU90717 C LU 90717C LU 90717 C LU90717 C LU 90717C LU 90717 I2 LU90717 I2 LU 90717I2
Authority
LU
Luxembourg
Prior art keywords
liposomes
drug
citrate
antineoplastic agents
transmembrane
Prior art date
Application number
LU90717C
Other languages
English (en)
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21808094&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90717(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of LU90717I2 publication Critical patent/LU90717I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Steroid Compounds (AREA)
LU90717C 1987-03-05 2001-01-15 Complexe citrate-doxorubicine encapsul- dans des liposomes LU90717I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2215487A 1987-03-05 1987-03-05

Publications (1)

Publication Number Publication Date
LU90717I2 true LU90717I2 (fr) 2001-03-15

Family

ID=21808094

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90717C LU90717I2 (fr) 1987-03-05 2001-01-15 Complexe citrate-doxorubicine encapsul- dans des liposomes

Country Status (17)

Country Link
EP (2) EP0290296B1 (fr)
JP (1) JP2882607B2 (fr)
KR (1) KR960013703B1 (fr)
AT (2) ATE231389T1 (fr)
AU (3) AU620545B2 (fr)
BR (1) BR1100687A (fr)
CA (1) CA1338702C (fr)
DE (3) DE10199004I1 (fr)
DK (1) DK174869B1 (fr)
ES (2) ES2198429T3 (fr)
GR (1) GR3020725T3 (fr)
HK (1) HK1007500A1 (fr)
IE (1) IE75713B1 (fr)
IL (1) IL85608A (fr)
LU (1) LU90717I2 (fr)
NL (1) NL300036I1 (fr)
WO (1) WO1988006442A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112023059A (zh) * 2020-06-03 2020-12-04 太原师范学院 一种pH响应型阿霉素无载体纳米药物及其制备方法和应用

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CA1338702C (fr) * 1987-03-05 1996-11-12 Lawrence D. Mayer Formulations d'agents liposomiques-antineoplasiques a faible teneur en medicaments-lipides
CA1323306C (fr) * 1987-03-05 1993-10-19 Mircea C. Popescu Preparation comprenant une solution lipidique et un agent pharmacologique
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
IE63518B1 (en) * 1987-11-18 1995-05-03 Vestar Inc Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
WO1990014105A1 (fr) * 1989-05-15 1990-11-29 The Liposome Company, Inc. Accumulation de medicaments dans des liposomes au moyen d'un gradient protonique
US5227170A (en) * 1989-06-22 1993-07-13 Vestar, Inc. Encapsulation process
EP0412507A1 (fr) * 1989-08-08 1991-02-13 Humboldt-Universität zu Berlin Procédé pour fractionner des produits de haut poids moléculaire avec des corps creux
WO1992002244A1 (fr) * 1990-07-31 1992-02-20 The Liposome Company, Inc. Accumulation d'acides amines et de peptides dans des liposomes
WO1992004009A1 (fr) * 1990-09-10 1992-03-19 School Of Pharmacy, University Of London Liposomes
DE4038075C1 (en) * 1990-11-29 1992-03-19 B. Braun Melsungen Ag, 3508 Melsungen, De Encapsulating solid or liq. lipophilic agents - comprises mixing hydration medium with phospholipid increasing temp. to above soln. phase change temp. and adding remaining medium
EP0661044A1 (fr) * 1991-07-03 1995-07-05 NeXstar Pharmaceuticals, Inc. Liposomes contenant un médicament
EP0546951A1 (fr) * 1991-12-13 1993-06-16 The Liposome Company, Inc. Combinaison d'agents antinéoplastiques, tels que la doxorubicine, encapsulés dans des liposomes, avec des tacteurs de stimulation de colonies
US5543152A (en) * 1994-06-20 1996-08-06 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5741516A (en) * 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
DE4430592A1 (de) * 1994-08-20 1996-02-22 Max Delbrueck Centrum Liposomale Zubereitung, ihre Herstellung und ihre Verwendung
US5858397A (en) * 1995-10-11 1999-01-12 University Of British Columbia Liposomal formulations of mitoxantrone
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
AU725257B2 (en) * 1996-10-15 2000-10-12 Transave, Inc. N-acyl phosphatidylethanolamine-mediated liposomal drug delivery
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US7351427B2 (en) 1998-06-18 2008-04-01 Busulipo Ab Pharmaceutical composition, a method of preparing it and a method of treatment by use thereof
ATE311870T1 (de) * 1998-06-18 2005-12-15 Hassan Moustapha Dr Liposomformulationen mit busulphan
CA2389147A1 (fr) * 1999-11-05 2001-05-10 Seed Capital Investment-2 (Sci-2) B.V. Procede de formulation de substances a hydrosolubilite et lipophilie faibles et formulation ainsi obtenue
AU2001260270A1 (en) * 2000-05-02 2001-11-12 Pharmacept Gmbh Liposomes containing active substances
AU2002312777B2 (en) * 2001-03-27 2007-07-05 Phares Pharmaceutical Research N.V. Method and composition for solubilising a biologically active compound with low water solubility
AU2002334358B2 (en) * 2001-09-06 2008-02-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem A method for preparing liposome formulations with a predefined release profile
US9186322B2 (en) 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
WO2004054499A2 (fr) * 2002-08-02 2004-07-01 Transave, Inc. Agregats de platine, et procede de fabrication correspondant
AU2003298738A1 (en) * 2002-11-26 2004-06-18 Su-Ming Chiang Liposomal formulations
DE60330745D1 (de) * 2002-12-31 2010-02-11 Bharat Serums & Vaccines Ltd Nicht-pegylierte lang-zirkulierende Liposome
WO2005072776A2 (fr) * 2004-01-30 2005-08-11 Instytut Farmaceutyczny Formulations liposomales d'agents antineoplasiques
WO2005092388A1 (fr) * 2004-03-26 2005-10-06 Terumo Kabushiki Kaisha Preparation de liposome
US20060051406A1 (en) * 2004-07-23 2006-03-09 Manjeet Parmar Formulation of insoluble small molecule therapeutics in lipid-based carriers
EP1847315A4 (fr) * 2005-01-18 2013-04-17 Univ Hokkaido Nat Univ Corp Procédé de revêtement de particules avec un film lipidique
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
EP1959961A2 (fr) 2005-12-06 2008-08-27 Rigel Pharmaceuticals, Inc. Formulation d'agents thérapeutiques à base de petites molécules insolubles dans des supports lipidiques
US20110244028A1 (en) * 2008-09-26 2011-10-06 Steve Leigh Method of solubilizing biologically active compounds
CN101474155B (zh) * 2009-01-24 2011-03-16 重庆医科大学 注射用肺靶向载药前体脂质体及其使用方法
PL387296A1 (pl) * 2009-02-17 2010-08-30 Instytut Farmaceutyczny Sposób aktywnego zamykania amfifilowych substancji czynnych w strukturach liposomowych
US8906409B2 (en) * 2009-06-08 2014-12-09 Epitarget As Acoustically sensitive drug delivery particles comprising non-lamellar forming phosphatidylcholine
PL226015B1 (pl) 2011-03-03 2017-06-30 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Liposomowy preparat zawierajacy przeciwnowotworowa substancje aktywna, sposob jego wytwarzania i zawierajaca go kompozycja farmaceutyczna
EP2892524B1 (fr) 2012-09-04 2020-11-25 Eleison Pharmaceuticals, LLC Prévention de la rechute du cancer pulmonaire avec un complexe lipide/cisplatine
WO2014081887A1 (fr) 2012-11-20 2014-05-30 Spectrum Pharmaceuticals Méthode améliorée pour la préparation de vincristine encapsulée dans des liposomes à usage thérapeutique
TWI678213B (zh) 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
CA3050686A1 (fr) 2017-01-18 2018-07-26 Temasek Life Sciences Laboratory Limited Liposomes hyperstabilises augmentant le ciblage de cellules mitotiques
GR20180100082A (el) * 2018-02-28 2019-09-25 ΝΙΚΟΛΑΟΣ Α. ΦΙΚΙΩΡΗΣ ΚΑΙ ΣΙΑ ΕΤΑΙΡΕΙΑ ΠΕΡΙΟΡΙΣΜΕΝΗΣ ΕΥΘΗΝΗΣ με δ.τ. IN TOUCH HEALTH Ε.Π.Ε Μεθοδος για την παραγωγη οχηματων μεταφορας λιπιδιων
AU2020367786A1 (en) * 2019-10-14 2022-05-26 The Regents Of The University Of California Nano-enabled immunotherapy in cancer
CN116407548A (zh) * 2021-12-31 2023-07-11 南京绿叶制药有限公司 一种蒽环类抗肿瘤药和铂类抗肿瘤药的组合物及其制备方法

Family Cites Families (9)

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EP0088046B1 (fr) * 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipides en phase aqueuse
US4551288A (en) * 1982-08-16 1985-11-05 Sandoz, Inc. Processes for the preparation of liposome drug delivery systems
GB8325496D0 (en) * 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions
CA1264668C (fr) * 1984-06-20 1990-01-23 Techniques d'extrusion pour la production de liposomes
CA1270198A (fr) * 1984-08-08 1990-06-12 Marcel B. Bally Encapsulation d'agents antineoplastiques dans des liposones
US4622188A (en) * 1984-12-21 1986-11-11 E. I. Du Pont De Nemours And Company Method for manufacturing liposomes
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
CA1338702C (fr) * 1987-03-05 1996-11-12 Lawrence D. Mayer Formulations d'agents liposomiques-antineoplasiques a faible teneur en medicaments-lipides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112023059A (zh) * 2020-06-03 2020-12-04 太原师范学院 一种pH响应型阿霉素无载体纳米药物及其制备方法和应用
CN112023059B (zh) * 2020-06-03 2023-03-24 太原师范学院 一种pH响应型阿霉素无载体纳米药物及其制备方法和应用

Also Published As

Publication number Publication date
EP0290296A2 (fr) 1988-11-09
IE880599L (en) 1988-09-05
DE3856550T2 (de) 2003-12-11
EP0290296B1 (fr) 1996-05-08
IL85608A0 (en) 1988-08-31
AU8141891A (en) 1991-10-10
DK98189A (da) 1989-03-01
DE3856550D1 (de) 2003-02-27
BR1100687A (pt) 2000-02-08
ATE231389T1 (de) 2003-02-15
CA1338702C (fr) 1996-11-12
EP0719546A1 (fr) 1996-07-03
IE75713B1 (en) 1997-09-24
KR960013703B1 (ko) 1996-10-10
GR3020725T3 (en) 1996-11-30
EP0290296A3 (en) 1989-06-28
JP2882607B2 (ja) 1999-04-12
DK98189D0 (da) 1989-03-01
ATE137670T1 (de) 1996-05-15
KR890700340A (ko) 1989-04-24
IE960340L (en) 1988-09-05
NL300036I1 (nl) 2001-03-01
WO1988006442A1 (fr) 1988-09-07
EP0719546B1 (fr) 2003-01-22
JPH02502458A (ja) 1990-08-09
AU8141791A (en) 1991-11-07
AU645332B2 (en) 1994-01-13
DE3855265D1 (de) 1996-06-13
ES2088385T3 (es) 1996-08-16
AU1481688A (en) 1988-09-26
DE3855265T2 (de) 1996-12-12
AU620545B2 (en) 1992-02-20
AU635435B2 (en) 1993-03-18
DE10199004I1 (de) 2001-03-29
IL85608A (en) 1992-07-15
DK174869B1 (da) 2004-01-12
ES2198429T3 (es) 2004-02-01
HK1007500A1 (en) 1999-04-16

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