LU92301I2 - "Nepafenac - suspension ophtalmique" - Google Patents

"Nepafenac - suspension ophtalmique"

Info

Publication number
LU92301I2
LU92301I2 LU92301C LU92301C LU92301I2 LU 92301 I2 LU92301 I2 LU 92301I2 LU 92301 C LU92301 C LU 92301C LU 92301 C LU92301 C LU 92301C LU 92301 I2 LU92301 I2 LU 92301I2
Authority
LU
Luxembourg
Prior art keywords
nepafenac
ophthalmic suspension
compositions
eye
ophthalmic
Prior art date
Application number
LU92301C
Other languages
English (en)
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21988983&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU92301(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of LU92301I2 publication Critical patent/LU92301I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LU92301C 1997-07-29 2013-10-31 "Nepafenac - suspension ophtalmique" LU92301I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5413297P 1997-07-29 1997-07-29

Publications (1)

Publication Number Publication Date
LU92301I2 true LU92301I2 (fr) 2013-12-31

Family

ID=21988983

Family Applications (1)

Application Number Title Priority Date Filing Date
LU92301C LU92301I2 (fr) 1997-07-29 2013-10-31 "Nepafenac - suspension ophtalmique"

Country Status (19)

Country Link
US (6) US6403609B1 (fr)
EP (2) EP1348427B1 (fr)
JP (2) JP3979783B2 (fr)
KR (1) KR100507984B1 (fr)
CN (3) CN100408100C (fr)
AR (1) AR013272A1 (fr)
AT (2) ATE391492T1 (fr)
AU (1) AU737442B2 (fr)
BR (1) BR9811574B1 (fr)
CA (1) CA2296080C (fr)
CY (2) CY1110365T1 (fr)
DE (2) DE69818675T2 (fr)
DK (2) DK0999825T3 (fr)
ES (2) ES2206965T3 (fr)
LU (1) LU92301I2 (fr)
PT (2) PT999825E (fr)
TW (2) TW577751B (fr)
WO (1) WO1999006023A1 (fr)
ZA (1) ZA986533B (fr)

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872710B2 (en) * 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
BR9806123A (pt) 1997-07-29 1999-08-31 Alcon Lab Inc Soluções condicionantes para cuidado de lente de contato dura
DE69818675T2 (de) 1997-07-29 2004-07-29 Alcon Laboratories, Inc., Fort Worth Galaktomannanpolymere und borat enthaltende augenarzneimittel
US7169755B2 (en) 2000-12-20 2007-01-30 Alcon, Inc. Solution for removing cataracts via liquefracture
US20090258955A1 (en) * 2000-12-20 2009-10-15 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
AU3960102A (en) * 2000-12-20 2002-07-01 Alcon Universal Ltd Intraocular irrigating solution having improved flow characteristics
US7084130B2 (en) * 2001-12-11 2006-08-01 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
US6878694B2 (en) 2000-12-20 2005-04-12 Alcon, Inc. Ophthalmic irrigating solution adapted for use in lasik surgery
WO2002049611A2 (fr) 2000-12-20 2002-06-27 Alcon, Inc. Solution ophtalmique lubrifiante convenant a la chirurgie lasik
GB2395507B (en) * 2001-06-22 2006-02-15 Bj Services Co Fracturing fluids and methods of making and using same
FR2832223B1 (fr) 2001-11-15 2005-01-14 Cit Alcatel Composant monolithique electro-optique multisections
US20050003014A1 (en) 2001-12-21 2005-01-06 Ketelson Howard Allen Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs
EP1471925A2 (fr) * 2001-12-21 2004-11-03 Alcon, Inc. Utilisation de nanoparticules inorganiques dans le but de modifier la viscosite et d'autres proprietes physiques de compositions pharmaceutiques ophtalmiques et otiques
US8097270B2 (en) * 2001-12-21 2012-01-17 Novartis Ag Use of nanoparticles as carriers for biocides in ophthalmic compositions
JP2005521690A (ja) * 2002-02-22 2005-07-21 ファルマシア・コーポレーション ゴム系を含む眼科用製剤
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
JP4653861B2 (ja) 2002-06-25 2011-03-16 ローディア インク． 電子ビームによる多糖類の分子量低減
CN1671721A (zh) * 2002-06-25 2005-09-21 罗狄亚公司 瓜尔胶和其它多糖用电子束接枝聚合的方法
KR101016595B1 (ko) 2002-07-31 2011-02-22 센주 세이야꾸 가부시키가이샤 수성액제 및 광안정화된 수성액제
US8877168B1 (en) 2002-07-31 2014-11-04 Senju Pharmaceuticals Co., Ltd. Aqueous liquid preparations and light-stabilized aqueous liquid preparations
EP2218448B1 (fr) 2002-12-13 2015-09-23 Durect Corporation Forme d'administration orale de medicaments comprenant un vehicule liquide de haute viscosite
US7914803B2 (en) 2003-06-13 2011-03-29 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of three polymers
TWI336257B (en) * 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
US7947295B2 (en) * 2003-06-13 2011-05-24 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
AU2012205283B2 (en) * 2003-06-13 2014-08-07 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
CA2839849C (fr) * 2003-06-13 2017-03-07 Alcon, Inc. Compositions ophtalmologiques contenant une association synergique de deux polymeres
US20050129770A1 (en) * 2003-12-11 2005-06-16 Alcon, Inc. Ophthalmic compositions containing a PVA/borate gelling system
WO2005060933A1 (fr) * 2003-12-11 2005-07-07 Alcon, Inc. Compositions ophtalmologiques contenant un systeme gelifiant a base de polysaccharide/borate
US20050137166A1 (en) * 2003-12-19 2005-06-23 Alcon, Inc. Use of cooling agents to relieve mild ocular irritation and enhance comfort
EP1720579A1 (fr) * 2004-02-17 2006-11-15 Wheli Inter AG Galactomannane et/ou glucomannane pour augmenter la disponibilite biologique d'agents actifs
CN1933833B (zh) * 2004-03-18 2011-09-07 株式会社·R-技术上野 含有噻唑衍生物的含水组合物
US7022740B2 (en) * 2004-04-29 2006-04-04 Leonard Mackles Lubricious ophthalmic solutions
KR100665299B1 (ko) * 2004-06-10 2007-01-04 서울반도체 주식회사 발광물질
CN101111224B (zh) * 2004-08-03 2012-11-14 罗迪亚公司 多糖接枝共聚物及其在个人护理应用中的用途
JP4771044B2 (ja) * 2004-09-15 2011-09-14 大正製薬株式会社 粘膜適用液剤
DK2767292T3 (en) 2004-09-17 2016-12-19 Durect Corp RENEWABLE local anesthetic COMPOSITION CONTAINING SAIB
US20070059274A1 (en) * 2004-12-01 2007-03-15 Bahram Asgharian Ophthalmic compositions containing a PVA/borate gelling system
US8318210B2 (en) 2005-02-28 2012-11-27 Neos Therapeutics, Lp Compositions and methods of making sustained release liquid formulations
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20070048338A1 (en) * 2005-08-26 2007-03-01 Ladd Byron S Compositions and methods for surface treatment in medical and surgical procedures
US20070254841A1 (en) * 2006-01-25 2007-11-01 Ophthalmic Research Associates, Inc. Formulations and methods for treating dry eye
US20100130580A1 (en) * 2006-01-25 2010-05-27 Aciex Therapeutics, Inc. Formulations and Methods for Treating Dry Eye
US20070259021A1 (en) * 2006-05-01 2007-11-08 Friedlaender Mitchell H Compositions, Methods, and Kits for Treating Dry Eye
WO2008036855A2 (fr) * 2006-09-21 2008-03-27 Alcon Research, Ltd. Compositions pharmaceutiques aqueuses auto-conservées
TWI394564B (zh) * 2006-09-21 2013-05-01 Alcon Res Ltd 自行保存型水性藥學組成物
MX2009003042A (es) * 2006-09-28 2009-04-02 Alcon Res Ltd Composiciones farmaceuticas acuosas auto-preservadas.
AU2007325918B2 (en) 2006-11-03 2013-10-17 Durect Corporation Transdermal delivery systems comprising bupivacaine
AU2007343701B2 (en) * 2007-01-16 2013-01-31 Texas Tech University System Method and apparatus for gender selection based on pH
KR101555291B1 (ko) * 2007-02-09 2015-09-30 알콘, 인코퍼레이티드 세가지 폴리머의 상승성 배합물을 함유하는 안과 조성물
EP2084264A1 (fr) * 2007-03-09 2009-08-05 Corning Incorporated Matrices de gomme tridimensionnelles pour une culture cellulaire, procédés de fabrication et procédés d'utilisation
US20080220526A1 (en) * 2007-03-09 2008-09-11 Ellison Adam J Gum coatings for cell culture, methods of manufacture and methods of use
CN101754748A (zh) * 2007-05-24 2010-06-23 阿西克斯医疗公司 治疗干眼症的制剂和方法
US20090131303A1 (en) * 2007-11-16 2009-05-21 Bor-Shyue Hong Methods and compositions for treating dry eye
EP2067471B1 (fr) * 2007-12-06 2018-02-14 Durect Corporation Formes orales de dosage pharmaceutique
US7795316B1 (en) 2007-12-19 2010-09-14 Alcon Research, Ltd. Topical ophthalmic compositions containing tobramycin and dexamethasone
AU2009225931B9 (en) * 2008-03-17 2014-04-03 Novartis Ag Aqueous pharmaceutical compositions containing borate-polyol complexes
AR071834A1 (es) * 2008-04-26 2010-07-21 Alcon Res Ltd Sistema polimerico de lagrimas artificiales
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
BRPI1008654A2 (pt) * 2009-02-05 2016-03-08 Alcon Res Ltd processo para purificação de guar
TW201039815A (en) 2009-04-13 2010-11-16 Resolvyx Pharmaceuticals Inc Compositions and methods for the treatment of inflammation
TWI489997B (zh) 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸－多元醇錯合物之水性藥學組成物
TWI547522B (zh) * 2009-07-07 2016-09-01 愛爾康研究有限公司 環氧乙烷環氧丁烷嵌段共聚物組成物
HUE038821T2 (hu) * 2009-12-03 2018-11-28 Novartis Ag Karboxivinil polimert tartalmazó nanorészecske szuszpenziók
TWI478730B (zh) * 2009-12-03 2015-04-01 Alcon Res Ltd 眼科乳劑
NZ603345A (en) * 2010-05-05 2014-12-24 Alcon Res Ltd Stabilized ophthalmic galactomannan formulations
AU2010356098B2 (en) * 2010-06-23 2014-08-14 Alcon Research, Ltd. Topical ophthalmic suspensions containing tobramycin and dexamethasone
EP3034509B1 (fr) 2010-10-26 2020-04-22 Mars, Incorporated Inhibiteurs d'arginase en tant qu'agents thérapeutiques
EP3045163A1 (fr) 2011-04-22 2016-07-20 Alcon Research, Ltd. Composition ophtalmique comprenant un système d'amélioration de la viscosité constitué de deux agents d'amélioration de la viscosité différents
MX2013012307A (es) 2011-04-22 2014-01-31 Alcon Res Ltd Composicion oftalmica con un sistema de mejoramiento de la viscosidad que tiene dos agentes mejoradores de la viscosidad diferentes.
CN108785305B (zh) 2011-11-21 2021-10-29 卡利泰拉生物科技公司 谷氨酰胺酶的杂环抑制剂
TW201336527A (zh) * 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
UA113434C2 (uk) 2012-05-04 2017-01-25 Алкон Рісерч, Лтд. Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням
CN102860949B (zh) * 2012-08-31 2014-07-02 马应龙药业集团股份有限公司 眼部抗皱护肤品及其制备方法
HUE056078T2 (hu) 2012-11-16 2022-01-28 Calithera Biosciences Inc Heterociklusos glutamináz inhibitorok
CA2905131A1 (fr) 2013-03-15 2014-09-18 Durect Corporation Compositions ayant un agent de modification rheologique pour reduire une variabilite de dissolution
WO2014207769A1 (fr) 2013-06-27 2014-12-31 Mylan Laboratories Ltd Procédé pour la préparation de népafénac
PT3973954T (pt) 2013-10-15 2026-07-17 Ntc S R L Composies farmacuticas sem conservantes para administrao oftlmica
FR3000391B3 (fr) 2013-11-12 2015-02-20 Pharmathen Sa Compositions pharmaceutiques sans conservateur pour administration ophtalmique
CN103572651B (zh) * 2013-11-25 2016-05-04 齐鲁工业大学 一种改性塔拉胶及其制备方法与应用
WO2015142853A1 (fr) * 2014-03-17 2015-09-24 Encompass Development, Inc. Formulations oculaires
SG11201610333VA (en) 2014-06-13 2017-01-27 Calithera Biosciences Inc Combination therapy with glutaminase inhibitors
JP6889101B2 (ja) 2014-08-07 2021-06-18 キャリセラ バイオサイエンシーズ， インコーポレイテッド グルタミナーゼ阻害剤の結晶形態
TW201613902A (en) 2014-08-13 2016-04-16 Eolas Therapeutics Inc Difluoropyrrolidines as orexin receptor modulators
WO2016061145A1 (fr) 2014-10-13 2016-04-21 Symic Biomedical, Inc. Protéoglycanes synthétiques pour empêcher l'adhérence tissulaire
US20170368192A1 (en) 2014-10-13 2017-12-28 Symic Ip, Llc Luminal vessel coating for arteriovenous fistula
WO2016065083A1 (fr) 2014-10-21 2016-04-28 Symic Biomedical, Inc. Peptidoglycanes comprenant des peptides se fixant au collagène pour le traitement d'une lésion gastro-œsophagienne
KR102894264B1 (ko) 2015-03-10 2025-12-02 오리진 온콜로지 리미티드 면역조절제로서의 1,2,4-옥사다이아졸 및 티아다이아졸 화합물
AU2016281620B2 (en) 2015-06-23 2021-07-22 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US20170037303A1 (en) 2015-08-03 2017-02-09 Ecolab Usa Inc. Compositions and methods for delayed crosslinking in hydraulic fracturing fluids
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
SG11201802830QA (en) 2015-10-05 2018-05-30 Calithera Biosciences Inc Combination therapy with glutaminase inhibitors and immuno-oncology agents
US20170112941A1 (en) 2015-10-13 2017-04-27 Symic Ip, Llc Ve-cadherin binding bioconjugate
EP3365022A4 (fr) * 2015-10-25 2019-07-24 IVIEW Therapeutics, Inc. Formulations pharmaceutiques qui forment un gel in situ
DK3368541T3 (da) 2015-10-30 2020-06-29 Calithera Biosciences Inc Sammensætninger og metoder til inhibiering af arginaseaktivitet
EP3377512A4 (fr) 2015-11-16 2019-09-18 Ichorion Therapeutics, Inc. Promédicaments d'acides nucléiques
JP6703408B2 (ja) * 2016-01-30 2020-06-03 国立大学法人 筑波大学 ポリイオンコンプレックスを有効成分とするドライアイ処置用組成物
US10894789B2 (en) 2016-02-12 2021-01-19 Astrazeneca Ab Halo-substituted piperidines as orexin receptor modulators
US10087363B2 (en) * 2016-03-15 2018-10-02 Baker Hughes, A Ge Company, Llc Using borated galactomannan to enhance swelling of superabsorbents for fracturing applications
CN109641003A (zh) 2016-04-22 2019-04-16 维京治疗股份有限公司 甲状腺β-激动剂的应用
WO2017210565A1 (fr) 2016-06-03 2017-12-07 Prisident And Fellows Of Harvard College Composés antifongiques
CN109475505A (zh) 2016-07-06 2019-03-15 度瑞公司 具有药物组成物、屏障层及药物层的口服剂型
US10550315B2 (en) 2016-07-15 2020-02-04 Ecolab Usa Inc. Compositions and methods for delayed crosslinking in hydraulic fracturing fluids
US11464810B2 (en) 2016-08-25 2022-10-11 California Institute Of Technology Ascaroside treatment of eosinophilic esophagitis
WO2018049027A1 (fr) 2016-09-07 2018-03-15 Trustees Of Tufts College Polythérapies mettant en oeuvre des inhibiteurs d'immuno-dash et des antagonistes de pge2
CN110234656B (zh) 2016-09-09 2023-02-28 卡利泰拉生物科技公司 外核苷酸酶抑制剂及其使用方法
US10980767B2 (en) 2016-09-09 2021-04-20 The Regents Of The University Of California Estrogen receptor ligands, compositions and methods related thereto
WO2018053126A1 (fr) 2016-09-14 2018-03-22 Vanderbilt University Inhibition de la signalisation bmp, composés, compositions et leurs utilisations
AU2017330443B2 (en) 2016-09-26 2023-08-24 Dana-Farber Cancer Institute, Inc. Chromobox protein inhibitors and uses thereof
US11291674B2 (en) 2016-11-08 2022-04-05 Calithera Biosciences, Inc. Arginase inhibitor combination therapies
WO2018119440A1 (fr) 2016-12-22 2018-06-28 Calithera Biosciences, Inc. Compositions et procédés pour inhiber l'activité de l'arginase
US20200054643A1 (en) 2017-01-18 2020-02-20 Vanderbilt University Fused heterocyclic compounds as selective bmp inhibitors
MA47593A (fr) 2017-02-24 2020-01-01 Merck Patent Gmbh Dérivés de 1, 4, 6-trisubstitué-2-alkyl-1h-benzo[d]imidazole en tant qu'inhibiteurs de dihydroorotate oxygénase
CN120267671A (zh) 2017-03-31 2025-07-08 奥锐金肿瘤有限公司 用于治疗血液病的化合物和组合物
US10994025B2 (en) 2017-05-12 2021-05-04 Massachusetts Institute Of Technology Argonaute protein-double stranded RNA complexes and uses related thereto
WO2018223032A1 (fr) 2017-06-02 2018-12-06 Stealth Biotherapeutics Corp. Formes cristallines de sel de sbt-20
EP3655379B1 (fr) 2017-07-19 2023-04-05 California Institute of Technology Procédés de préparation de composés contenant bis-tétrahydroisoquinoline
CA3075813A1 (fr) 2017-10-04 2019-04-11 Dana-Farber Cancer Institute, Inc. Inhibition par des petites molecules du facteur de transcription sall4 et ses utilisations
AU2018348350B2 (en) 2017-10-11 2024-05-02 Aurigene Oncology Limited Crystalline forms of 3-substituted 1,2,4-oxadiazole
ES2960541T3 (es) 2017-10-19 2024-03-05 Signpath Pharma Inc Composiciones líquidas para una utilización peroral que comprenden derivados de fosfatidilglicerol y excipientes tixotrópicos para tratar canalopatías cardíacas causadas por agentes farmacológicos
EP4410377A3 (fr) 2017-10-31 2024-11-13 Curis, Inc. Composés et compositions pour le traitement de troubles hématologiques
MX2020004531A (es) 2017-11-03 2020-08-03 Aurigene Discovery Tech Ltd Inhibidores dobles de tim-3 y las vias de pd-1.
EP3706798A1 (fr) 2017-11-06 2020-09-16 Aurigene Discovery Technologies Limited Thérapies conjointes à des fins d'immunomodulation
RU2020124097A (ru) 2017-12-22 2022-01-24 Медиммьюн Лимитед НИЗКОМОЛЕКУЛЯРНЫЕ МОДУЛЯТОРЫ ДОМЕНА BTB Keap1
TWI913170B (zh) 2018-02-21 2026-01-21 瑞士商愛爾康公司 基於脂質的眼用乳劑
WO2019178383A1 (fr) 2018-03-14 2019-09-19 Vanderbilt University Inhibition de la signalisation bmp, composés, compositions et leurs utilisations
EP3768259A4 (fr) 2018-03-14 2022-04-06 Aurigene Discovery Technologies Limited Procédé de modulation de voies de signalisation de tigit et pd-1 à l'aide de composés 1,2,4-oxadiazole
WO2020023917A1 (fr) 2018-07-27 2020-01-30 California Institute Of Technology Inhibiteurs de cdk et leurs utilisations
CN110787126A (zh) * 2018-08-03 2020-02-14 武汉武药科技有限公司 一种盐酸莫西沙星眼用凝胶及其制备方法
JP2021535181A (ja) 2018-09-05 2021-12-16 ザ ジェネラル ホスピタル コーポレイション サイトカイン放出症候群を処置する方法
US20220047546A1 (en) 2018-09-12 2022-02-17 The Board Of Regents Of The University Of Oklahoma Combination cancer therapies
CA3117695A1 (fr) 2018-10-26 2020-04-30 Keros Therapeutics, Inc. Formes cristallines d'un inhibiteur d'alk2
EP3873912B1 (fr) 2018-10-31 2026-03-25 Intocell, Inc. Dérivés de benzodiazépine hétérocycliques fusionnés et leurs utilisations
US12383528B2 (en) 2018-12-10 2025-08-12 The General Hospital Corporation Cromolyn esters and uses thereof
BR112021013924A2 (pt) 2019-01-18 2021-09-21 Astrazeneca Ab Inibidores de pcsk9 e métodos de uso do mesmo
WO2020150473A2 (fr) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Inhibiteurs de pcsk9 et leurs procédés d'utilisation
MX2021011105A (es) 2019-03-14 2021-10-22 Astrazeneca Ab Lanabecestat para la perdida de peso.
TW202045631A (zh) 2019-03-15 2020-12-16 德商麥克專利有限公司 帶藍色之深黑色效果顏料
EP3978076A4 (fr) 2019-06-03 2023-02-22 Irimajiri Therapeutics Inc. Composés d'amide cyclique pour le traitement de la rage et méthode associée
TWI757773B (zh) * 2019-06-28 2022-03-11 瑞士商愛爾康公司 眼用組成物
BR112022002467A2 (pt) 2019-09-18 2022-07-19 Alcon Inc Insertos oculares de hidrogel suave embalados a úmido
MX2022005810A (es) 2019-11-12 2022-06-08 Genzyme Corp Heteroarilaminosulfonamidas de 6 miembros para tratar enfermedades y afecciones mediadas por la actividad de regulador de la conductancia transmembrana de la fibrosis quistica (cftr) deficiente.
WO2021113806A1 (fr) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides et leurs procédés d'utilisation
WO2021113809A1 (fr) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides et leurs procédés d'utilisation
CA3164800A1 (fr) 2019-12-16 2021-06-24 Unist(Ulsan National Institute Of Science And Technology) Compose destine a inhiber le facteur d'angiogenese et son utilisation
WO2021146215A1 (fr) 2020-01-13 2021-07-22 Durect Corporation Systèmes d'administration de médicament à libération prolongée avec impuretés réduites et procédés associés
KR102698413B1 (ko) 2020-05-05 2024-08-26 뉴베일런트, 아이엔씨. 헤테로방향족 거대환식 에터 화학치료제
WO2021226208A2 (fr) 2020-05-05 2021-11-11 Nuvalent, Inc. Agents chimiothérapeutiques à base d'éthers macrocycliques hétéroaromatiques
CA3203561A1 (fr) 2021-01-12 2022-07-21 Adrian Neil Verity Systemes d'administration de medicament a liberation prolongee et procedes associes
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
IL311038A (en) 2021-09-03 2024-04-01 Genzyme Corp Indole compounds and methods of use
WO2023034946A1 (fr) 2021-09-03 2023-03-09 Genzyme Corporation Composés indoles et leurs utilisations dans le traitement de la fibrose kystique
CA3231608A1 (fr) 2021-10-01 2023-04-06 Amit M. Deshpande Methodes de traitement d'une tumeur solide a l'aide de composes ether macrocycliques heteroaromatiques
TW202320768A (zh) 2021-10-01 2023-06-01 美商努法倫特公司 雜芳族大環醚化合物之固體形式、醫藥組成物及製備
CN114191378A (zh) * 2021-11-23 2022-03-18 温州医科大学附属眼视光医院 一种地夸磷索缓释凝胶及其制备方法与应用
WO2023187672A1 (fr) 2022-03-31 2023-10-05 Alcon Inc. Compositions ophtalmiques
WO2023196910A1 (fr) 2022-04-07 2023-10-12 Nuvalent, Inc Méthodes de traitement d'une tumeur solide à l'aide de (19r)-5-chloro-3-éthyl-16-fluoro-10,19-diméthyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,6. 08,12.013,18]pentacosa-1(24), 2(6),4,8,11,13,15,17,21(25),22-décaén-22-amine
JP2025512920A (ja) 2022-04-07 2025-04-22 ヌバレント， インク． ヘテロ芳香族大環状エーテル化合物の固体形態、薬学的組成物、及び調製
WO2023224961A1 (fr) 2022-05-16 2023-11-23 Exelixis, Inc. Thérapie anticancéreuse utilisant une association d'un inhibiteur de cdk7 avec un serd oral
IL318676A (en) 2022-08-04 2025-03-01 Dks Co Ltd Cyclic peptide derivative, method for producing same and composition
WO2024036097A1 (fr) 2022-08-12 2024-02-15 Nuvalent, Inc. Composés d'éther macrocycliques hétéroaromatiques et isotopologues de ceux-ci
EP4568969A1 (fr) 2022-08-12 2025-06-18 Nuvalent, Inc. Composés d'éther macrocycliques hétéroaromatiques
CN119947740A (zh) 2022-09-30 2025-05-06 第一工业制药株式会社 用于处置或预防眼科疾病的环状肽衍生物组合物
EP4578856A4 (fr) 2022-09-30 2026-07-29 Ubience Inc Composé hétérocyclique
WO2024086634A1 (fr) 2022-10-19 2024-04-25 Nuvalent, Inc. Agents chimiothérapeutiques à base d'éther macrocyclique hétéroaromatique
JPWO2024096067A1 (fr) 2022-11-04 2024-05-10
US20260151451A1 (en) 2022-11-04 2026-06-04 Dks Co. Ltd. Cyclic peptide derivative composition for treating or preventing central nervous system injury/disease
EP4705330A1 (fr) 2023-05-05 2026-03-11 The Board of Regents of the University of Oklahoma Variants d'adrénomédulline (am) et d'adrénomédulline 2/intermédine (am2/imd) et procédés d'utilisation
WO2025042868A1 (fr) 2023-08-23 2025-02-27 The Board Of Regents Of The University Of Oklahoma Combinaisons d'hétéroarotinoïdes et d'inhibiteurs glycolytiques destinées à être utilisées en tant que traitements du cancer
WO2025072117A1 (fr) 2023-09-25 2025-04-03 Nuvalent, Inc. Composés d'éther macrocycliques hétéroaromatiques et isotopologues de ceux-ci
EP4784587A1 (fr) 2023-09-25 2026-08-05 Nuvalent, Inc. Composés d'éther macrocycliques hétéroaromatiques
WO2025085360A1 (fr) 2023-10-16 2025-04-24 The Board Of Regents Of The University Of Oklahoma Hétéroarotinoïdes et/ou inhibiteurs de cdk4/6 pour le traitement des verrues, des dysplasies induites par le papillomavirus humain (vph), et du cancer chez des individus infectés par le vph
AU2025233965A1 (en) 2024-03-04 2026-07-16 Alcon Inc. Carbamoylphenylboronic acid-containing acrylic monomers and uses thereof
WO2026115440A1 (fr) 2024-11-27 2026-06-04 Alcon Inc. Émulsion ophtalmique stable
US20260144812A1 (en) 2024-11-27 2026-05-28 Alcon Inc. Antioxidant ophthalmic emulsion

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944427A (en) * 1970-04-06 1976-03-16 Itek Corporation Gelable and gelled compositions
US3843782A (en) 1971-07-26 1974-10-22 Flow Pharma Inc Eye solution and method of using same
US4136173A (en) 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
US4136177A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Xanthan gum therapeutic compositions
US4136178A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Locust bean gum therapeutic compositions
US4255415A (en) 1978-11-22 1981-03-10 Schering Corporation Polyvinyl alcohol ophthalmic gel
US4370325A (en) 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
US4436730A (en) 1979-06-25 1984-03-13 Polymer Technology Corporation Ionic opthalmic cellulose polymer solutions
US4624868A (en) * 1979-12-17 1986-11-25 Colgate-Palmolive Company Borated polysaccharide absorbents and absorbent products
US4323467A (en) 1980-11-24 1982-04-06 Syntex (U.S.A.) Inc. Contact lens cleaning, storing and wetting solutions
JPS57186733A (en) 1981-05-13 1982-11-17 Toyo Contact Lens Co Ltd Agent for use in contact lenses
US4362781A (en) * 1981-09-21 1982-12-07 Scott Paper Company Flushable premoistened wiper
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
FR2588189B1 (fr) * 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
US5457093A (en) 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
US5188826A (en) 1988-02-08 1993-02-23 Insite Vision Incorporated Topical ophthalmic suspensions
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
US5607698A (en) 1988-08-04 1997-03-04 Ciba-Geigy Corporation Method of preserving ophthalmic solution and compositions therefor
US5126141A (en) 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
CA2011423A1 (fr) 1989-03-07 1990-09-07 Peter M. Taylor Composes pharmaceutiques utiles comme vehicules de medicaments et (ou) pansement
US5160643A (en) 1990-01-16 1992-11-03 Bj Services Company Method for delaying the gellation of borated galactomannans with a delay additive such as glyoxal
US5145590A (en) 1990-01-16 1992-09-08 Bj Services Company Method for improving the high temperature gel stability of borated galactomannans
US5082579A (en) * 1990-01-16 1992-01-21 Bj Services Company Method and composition for delaying the gellation of borated galactomannans
US5346703A (en) 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5376693A (en) 1990-08-07 1994-12-27 Mediventures Inc. Thermo-irreversible gel corneal contact lens formed in situ
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5372732A (en) 1992-10-21 1994-12-13 Halliburton Company Delayed release borate crosslinking agent
WO1994010976A1 (fr) 1992-11-16 1994-05-26 Ciba Vision Ag, Hettlingen Systeme d'administration de medicaments ophtalmiques a base de borate/alcool polyvinylique
JPH06345653A (ja) 1993-06-08 1994-12-20 Asahi Chem Ind Co Ltd 点眼液
US5773025A (en) 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
US5603929A (en) 1994-11-16 1997-02-18 Alcon Laboratories, Inc. Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
US5972326A (en) 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
GB9603146D0 (en) 1996-02-15 1996-04-17 Innovative Tech Ltd Hydrogels
JP3989054B2 (ja) 1996-07-29 2007-10-10 株式会社メニコン コンタクトレンズ用洗浄材
JPH10221654A (ja) 1997-02-07 1998-08-21 Seiko Epson Corp コンタクトレンズ用溶液
DE69818675T2 (de) * 1997-07-29 2004-07-29 Alcon Laboratories, Inc., Fort Worth Galaktomannanpolymere und borat enthaltende augenarzneimittel
DK0999854T3 (da) 1997-07-29 2004-02-09 Alcon Mfg Ltd Omskiftelige viskoelastiske systemer, der indeholder galactomannanpolymerer og -borater
BR9806123A (pt) * 1997-07-29 1999-08-31 Alcon Lab Inc Soluções condicionantes para cuidado de lente de contato dura
WO2005060933A1 (fr) * 2003-12-11 2005-07-07 Alcon, Inc. Compositions ophtalmologiques contenant un systeme gelifiant a base de polysaccharide/borate

Also Published As

Publication number Publication date
US7169767B2 (en) 2007-01-30
US6838449B2 (en) 2005-01-04
ATE250923T1 (de) 2003-10-15
EP1348427B1 (fr) 2008-04-09
JP4673339B2 (ja) 2011-04-20
DE69839355T2 (de) 2009-06-04
DE69839355D1 (de) 2008-05-21
CN100408100C (zh) 2008-08-06
CN1762381A (zh) 2006-04-26
TW577751B (en) 2004-03-01
EP1348427A1 (fr) 2003-10-01
DK0999825T3 (da) 2004-02-09
JP2007197461A (ja) 2007-08-09
HK1026618A1 (en) 2000-12-22
WO1999006023A1 (fr) 1999-02-11
CN1229110C (zh) 2005-11-30
JP3979783B2 (ja) 2007-09-19
CA2296080A1 (fr) 1999-02-11
US6403609B1 (en) 2002-06-11
CN1762381B (zh) 2012-07-11
US6583124B2 (en) 2003-06-24
US20030206970A1 (en) 2003-11-06
KR20010022286A (ko) 2001-03-15
US20020183280A1 (en) 2002-12-05
CN1302201A (zh) 2001-07-04
CY2013040I1 (el) 2015-11-04
CA2296080C (fr) 2005-02-01
PT1348427E (pt) 2008-05-26
US20070098677A1 (en) 2007-05-03
ES2206965T3 (es) 2004-05-16
DK1348427T3 (da) 2008-06-30
DE69818675T2 (de) 2004-07-29
ZA986533B (en) 1999-02-05
TWI233801B (en) 2005-06-11
US6486138B1 (en) 2002-11-26
BR9811574A (pt) 2000-08-29
AU737442B2 (en) 2001-08-16
EP0999825B1 (fr) 2003-10-01
BR9811574B1 (pt) 2010-11-30
CY2013040I2 (el) 2015-11-04
CN1544092A (zh) 2004-11-10
US20050075313A1 (en) 2005-04-07
PT999825E (pt) 2004-02-27
ATE391492T1 (de) 2008-04-15
AU8570598A (en) 1999-02-22
JP2003528797A (ja) 2003-09-30
ES2302881T3 (es) 2008-08-01
AR013272A1 (es) 2000-12-13
HK1055392A1 (en) 2004-01-09
KR100507984B1 (ko) 2005-08-17
EP0999825A1 (fr) 2000-05-17
CY1110365T1 (el) 2015-04-29
DE69818675D1 (de) 2003-11-06

Similar Documents

Publication Publication Date Title
CA2296080A1 (fr) Compositions ophtalmologiques contenant des polymeres de galactomannan et du borate
AU6772590A (en) Hair treatment composition
NO975331D0 (no) Anvendelse av R-enantiomer av N-propargyl-1-aminoindan salter og sammensetninger derav
CA2154950A1 (fr) Nouvelles composition et methode de fracturation
FR2719769B1 (fr) Composition cosmétique ou dermatologique sous forme d'huile gélifiée contenant un mélange d'acide hydroxy-12 stéarique ou d'un dialkylamide de l'acide N-lauroylglutamique et d'un copolymère styrène/alcadiène hydrogéné.
FI970489L (fi) Paikallisesti käytettäviä silmälääkekoostumuksia, jotka sisältävät doksepiinijohdoksia ja soveltuvat allergisten silmäsairauksien hoitoon
DE3581768D1 (de) Tensidepraeparate.
TR199600499A2 (tr) S(+)-Etodolak'in oral formülasyonlari.
ATE215821T1 (de) Entzündungshemmende augentropfen
MA22352A1 (fr) Compositions de type gel ayant une regulation perfectionnee de l'huile
DE69325493D1 (de) Künstliche Speichelzusammensetzungen
BG102342A (en) Optical active derivative of phenylpyrimidine as an anlgesics
PL314800A1 (en) Application of dimeticone in treating aphthae and oral cavity inflammations
YU48341B (sh) Preparat herbicida
ATE195055T1 (de) Insektizide zusammensetzung die diatomeenerde und siliziumdioxid enthalten
BR9303862A (pt) Mesofase esmetica preparada "in vitro" e composicao cosmetica
NO974551D0 (no) Bruk av sulbutiamin for å fremskaffe farmasöytiske sammensetninger nyttige i behandling av visse psykomotoriske- og psyko-intellektuelle sykdommer
EP0824453A4 (fr) Nouvelles utilisations d'heptafluoropropane
IT9002117A0 (it) Procedimento per l'applicazione dello sperone e calzature costruite secondo il procedimento.
ITFI910140V0 (it) Presidio dell'articolazione scapolo-omerale
DE59604930D1 (de) Gelbildner, Brandschutzgele und Brandschutzgläser
AUPM656494A0 (en) Organism's light computer & games of triangles
FR2743494B1 (fr) Composition aqueuse dentaire a base d'un melange de gomme xanthane et de gomme de guar comme agent epaississant
IT1282704B1 (it) Uso topico dell'invertasi nella prevenzione o nella cura della carie e delle patologie parodontali
ITPG950031U1 (it) Manico per cappuccio di siringa