ATE250923T1 - Galaktomannanpolymere und borat enthaltende augenarzneimittel - Google Patents

Galaktomannanpolymere und borat enthaltende augenarzneimittel

Info

Publication number
ATE250923T1
ATE250923T1 AT98936847T AT98936847T ATE250923T1 AT E250923 T1 ATE250923 T1 AT E250923T1 AT 98936847 T AT98936847 T AT 98936847T AT 98936847 T AT98936847 T AT 98936847T AT E250923 T1 ATE250923 T1 AT E250923T1
Authority
AT
Austria
Prior art keywords
borate
drugs containing
galactomannan polymers
containing galactomannan
eye drugs
Prior art date
Application number
AT98936847T
Other languages
English (en)
Inventor
Bahram Asgharian
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21988983&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE250923(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Application granted granted Critical
Publication of ATE250923T1 publication Critical patent/ATE250923T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/22Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/08Mydriatics or cycloplegics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT98936847T 1997-07-29 1998-07-17 Galaktomannanpolymere und borat enthaltende augenarzneimittel ATE250923T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5413297P 1997-07-29 1997-07-29
PCT/US1998/014596 WO1999006023A1 (en) 1997-07-29 1998-07-17 Ophthalmic compositions containing galactomannan polymers and borate

Publications (1)

Publication Number Publication Date
ATE250923T1 true ATE250923T1 (de) 2003-10-15

Family

ID=21988983

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03014536T ATE391492T1 (de) 1997-07-29 1998-07-17 Ophthalmische zusammensetzungen enthaltend galaktomannanpolymere und borat
AT98936847T ATE250923T1 (de) 1997-07-29 1998-07-17 Galaktomannanpolymere und borat enthaltende augenarzneimittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03014536T ATE391492T1 (de) 1997-07-29 1998-07-17 Ophthalmische zusammensetzungen enthaltend galaktomannanpolymere und borat

Country Status (19)

Country Link
US (6) US6403609B1 (de)
EP (2) EP0999825B1 (de)
JP (2) JP3979783B2 (de)
KR (1) KR100507984B1 (de)
CN (3) CN1762381B (de)
AR (1) AR013272A1 (de)
AT (2) ATE391492T1 (de)
AU (1) AU737442B2 (de)
BR (1) BR9811574B1 (de)
CA (1) CA2296080C (de)
CY (2) CY1110365T1 (de)
DE (2) DE69818675T2 (de)
DK (2) DK0999825T3 (de)
ES (2) ES2302881T3 (de)
LU (1) LU92301I2 (de)
PT (2) PT1348427E (de)
TW (2) TWI233801B (de)
WO (1) WO1999006023A1 (de)
ZA (1) ZA986533B (de)

Families Citing this family (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872710B2 (en) * 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
DK0999825T3 (da) 1997-07-29 2004-02-09 Alcon Lab Inc Oftalmiske sammensætninger indeholdende galactomannanpolymerer og borater
CA2264290C (en) 1997-07-29 2005-11-29 Alcon Laboratories, Inc. Conditioning solutions for contact lens care
US7169755B2 (en) 2000-12-20 2007-01-30 Alcon, Inc. Solution for removing cataracts via liquefracture
AU2002232437A1 (en) 2000-12-20 2002-07-01 Alcon Universal Ltd. Ophthalmic lubricating solution adapted for use in lasik surgery
US7084130B2 (en) * 2001-12-11 2006-08-01 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
JP2005502581A (ja) * 2000-12-20 2005-01-27 アルコン、インコーポレイテッド 改良された流動特性を有する眼内潅流溶液
AU2002230504A1 (en) 2000-12-20 2002-07-01 Alcon Universal Ltd. Ophthalmic irrigating solution adapted for use in lasik surgery
US20090258955A1 (en) * 2000-12-20 2009-10-15 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
GB2395507B (en) * 2001-06-22 2006-02-15 Bj Services Co Fracturing fluids and methods of making and using same
FR2832223B1 (fr) 2001-11-15 2005-01-14 Cit Alcatel Composant monolithique electro-optique multisections
KR20040073503A (ko) * 2001-12-21 2004-08-19 알콘, 인코퍼레이티드 안과용 및 이과용 약제학적 조성물의 점도 및 기타물리학적 성질을 개질시키기 위한 무기 나노입자의 용도
WO2003059193A2 (en) * 2001-12-21 2003-07-24 Alcon, Inc. Use of nanoparticles as carriers for biocides in ophthalmic compositions
BR0215238A (pt) 2001-12-21 2005-05-31 Alcon Inc Uso de nanopartìculas inor ânicas sintéticas como veìculos para drogas oftálmicas e óticas
EP1476135A1 (de) * 2002-02-22 2004-11-17 Pharmacia Corporation Ophthalmische formulierung mit gummi-system
WO2004000885A2 (en) 2002-06-25 2003-12-31 Rhodia, Inc. Molecular weight reduction of polysaccharides by electron beams
JP4718834B2 (ja) * 2002-06-25 2011-07-06 ローディア インク. 電子ビームによる、グァーおよび他の多糖類のグラフト重合
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
ATE528003T1 (de) * 2002-07-31 2011-10-15 Senju Pharma Co Wässrige, flüssigkeitszubereitungen und lichtstabilisierte wässrige flüssigkeitszubereitungen
US8877168B1 (en) 2002-07-31 2014-11-04 Senju Pharmaceuticals Co., Ltd. Aqueous liquid preparations and light-stabilized aqueous liquid preparations
ATE482695T1 (de) 2002-12-13 2010-10-15 Durect Corp Orale darreichungsform mit flüssigen hochviskosen trägersystemen
US7947295B2 (en) 2003-06-13 2011-05-24 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
TWI336257B (en) * 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
AU2012205283B2 (en) * 2003-06-13 2014-08-07 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
US7914803B2 (en) 2003-06-13 2011-03-29 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of three polymers
AU2004249137B2 (en) * 2003-06-13 2010-03-11 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
WO2005060933A1 (en) * 2003-12-11 2005-07-07 Alcon, Inc. Ophthalmic compositions containing a polysaccharide/borate gelling system
US20050129770A1 (en) * 2003-12-11 2005-06-16 Alcon, Inc. Ophthalmic compositions containing a PVA/borate gelling system
US20050137166A1 (en) * 2003-12-19 2005-06-23 Alcon, Inc. Use of cooling agents to relieve mild ocular irritation and enhance comfort
JP2007524690A (ja) * 2004-02-17 2007-08-30 ヴェーリ・インター・アーゲー 活性物質の生体内利用効率を高めるためのガラクトマンナン及び/又はグルコマンナン
WO2005089755A1 (en) * 2004-03-18 2005-09-29 R-Tech Ueno, Ltd. Aqueous composition comprising thiazole derivative
US7022740B2 (en) * 2004-04-29 2006-04-04 Leonard Mackles Lubricious ophthalmic solutions
KR100665299B1 (ko) * 2004-06-10 2007-01-04 서울반도체 주식회사 발광물질
EP1890670B1 (de) * 2004-08-03 2011-06-29 Rhodia, Inc. Polysaccharid-pfropfcopolymere und ihre verwendung bei der haarpflege
JP4771044B2 (ja) * 2004-09-15 2011-09-14 大正製薬株式会社 粘膜適用液剤
SI2415484T1 (sl) * 2004-09-17 2014-10-30 Durect Corporation Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem
US20070059274A1 (en) * 2004-12-01 2007-03-15 Bahram Asgharian Ophthalmic compositions containing a PVA/borate gelling system
US8318210B2 (en) 2005-02-28 2012-11-27 Neos Therapeutics, Lp Compositions and methods of making sustained release liquid formulations
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20070048338A1 (en) * 2005-08-26 2007-03-01 Ladd Byron S Compositions and methods for surface treatment in medical and surgical procedures
US20100130580A1 (en) * 2006-01-25 2010-05-27 Aciex Therapeutics, Inc. Formulations and Methods for Treating Dry Eye
AU2007208054A1 (en) * 2006-01-25 2007-08-02 Aciex Therapeutics, Inc. Formulations and methods for treating dry eye
WO2007130364A2 (en) * 2006-05-01 2007-11-15 Riolan Technologies, Inc. Compositions, methods, and kits for treating dry eye
TWI394564B (zh) * 2006-09-21 2013-05-01 Alcon Res Ltd 自行保存型水性藥學組成物
WO2008036855A2 (en) * 2006-09-21 2008-03-27 Alcon Research, Ltd. Self-preserved aqueous pharmaceutical compositions
KR101421519B1 (ko) * 2006-09-28 2014-07-30 알콘 리서치, 리미티드 자기 보존 수성 약제학적 조성물
AU2007325918B2 (en) 2006-11-03 2013-10-17 Durect Corporation Transdermal delivery systems comprising bupivacaine
US9157063B2 (en) * 2007-01-16 2015-10-13 Texas Tech University System Method and apparatus for gender selection based on pH
KR101555291B1 (ko) * 2007-02-09 2015-09-30 알콘, 인코퍼레이티드 세가지 폴리머의 상승성 배합물을 함유하는 안과 조성물
US8080418B2 (en) * 2007-03-09 2011-12-20 Corning Incorporated Method of making a three dimensional cell culture matrix
JP2010520765A (ja) * 2007-03-09 2010-06-17 コーニング インコーポレイテッド 細胞培養用ガムコーティング、製造方法および使用方法
CN101754748A (zh) * 2007-05-24 2010-06-23 阿西克斯医疗公司 治疗干眼症的制剂和方法
US20090131303A1 (en) * 2007-11-16 2009-05-21 Bor-Shyue Hong Methods and compositions for treating dry eye
JP2011506319A (ja) * 2007-12-06 2011-03-03 デュレクト コーポレーション 疼痛、関節炎症状、または慢性疾患に伴う炎症の治療に有用な方法
US7795316B1 (en) 2007-12-19 2010-09-14 Alcon Research, Ltd. Topical ophthalmic compositions containing tobramycin and dexamethasone
ES2638771T3 (es) * 2008-03-17 2017-10-24 Novartis Ag Composiciones farmacéuticas acuosas que contienen complejos de borato-poliol
CL2009000985A1 (es) * 2008-04-26 2010-01-15 Alcon Res Ltd Composicion oftalmica que comprende entre 0,16 y 0,19% p/v de un galactomanano, alrededor de 0,7% p/v de un borato, cis-diol y menos de 5 ppm de concentracion de cationes divalentes; y su uso para lubricar el ojo.
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
MX2011007714A (es) 2009-02-05 2011-12-06 Alcon Res Ltd Proceso para purificar goma guar.
TW201039815A (en) 2009-04-13 2010-11-16 Resolvyx Pharmaceuticals Inc Compositions and methods for the treatment of inflammation
TWI489997B (zh) * 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸-多元醇錯合物之水性藥學組成物
TWI547522B (zh) * 2009-07-07 2016-09-01 愛爾康研究有限公司 環氧乙烷環氧丁烷嵌段共聚物組成物
US8921337B2 (en) 2009-12-03 2014-12-30 Alcon Research, Ltd. Carboxyvinyl polymer-containing nanoparticle suspensions
TWI478730B (zh) 2009-12-03 2015-04-01 Alcon Res Ltd 眼科乳劑
JP5794744B2 (ja) 2010-05-05 2015-10-14 アルコン リサーチ, リミテッド 安定化された眼用ガラクトマンナン処方物
CN102946855B (zh) * 2010-06-23 2016-01-06 爱尔康研究有限公司 含有妥布霉素和地塞米松的局部用眼科混悬剂
DK2632927T3 (en) 2010-10-26 2016-04-11 Mars Inc Boronates AS ARGINSASEINHIBITORER
US20120269862A1 (en) 2011-04-22 2012-10-25 Chowhan Masood A Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents
BR112013026534A2 (pt) 2011-04-22 2016-12-27 Alcon Res Ltd composição oftálmica com um sistema de realce da viscosidade tendo dois diferentes agentes de realce da viscosidade
ES2761866T3 (es) 2011-11-21 2020-05-21 Calithera Biosciences Inc Inhibidores heterocíclicos de glutaminasa
TW201336527A (zh) * 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
UA113434C2 (uk) 2012-05-04 2017-01-25 Алкон Рісерч, Лтд. Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням
CN102860949B (zh) * 2012-08-31 2014-07-02 马应龙药业集团股份有限公司 眼部抗皱护肤品及其制备方法
BR112015010955A2 (pt) 2012-11-16 2017-07-11 Calithera Biosciences Inc inibidores de glutaminase heterocíclica
AU2014233453A1 (en) 2013-03-15 2015-10-01 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US9630909B2 (en) 2013-06-27 2017-04-25 Mylan Laboratories Ltd Process for the preparation of nepafenac
EP3057575B1 (de) 2013-10-15 2021-09-08 Pharmathen S.A. Konservierungsstofffreie pharmazeutische zusammensetzungen zur ophthalmischen verabreichung
FR3000391B3 (fr) 2013-11-12 2015-02-20 Pharmathen Sa Compositions pharmaceutiques sans conservateur pour administration ophtalmique
CN103572651B (zh) * 2013-11-25 2016-05-04 齐鲁工业大学 一种改性塔拉胶及其制备方法与应用
EP3119392A4 (de) * 2014-03-17 2017-10-11 Encompass Development Inc. Augenformulierungen
KR20170012562A (ko) 2014-06-13 2017-02-02 칼리테라 바이오사이언시즈 인코포레이티드 글루타미나제 억제제를 사용하는 병용 요법
CA2957225A1 (en) 2014-08-07 2016-02-11 Calithera Biosciences, Inc. Crystal forms of glutaminase inhibitors
JP6663909B2 (ja) 2014-08-13 2020-03-13 エオラス セラピューティクス, インコーポレイテッド オレキシンレセプターモジュレーターとしてのジフルオロピロリジン
WO2016061145A1 (en) 2014-10-13 2016-04-21 Symic Biomedical, Inc. Synthetic proteoglycans for preventing tissue adhesion
US20170368192A1 (en) 2014-10-13 2017-12-28 Symic Ip, Llc Luminal vessel coating for arteriovenous fistula
WO2016065083A1 (en) 2014-10-21 2016-04-28 Symic Biomedical, Inc. Peptidoglycans comprising collagen-binding peptides for treating gastroesophageal injury
NZ734650A (en) 2015-03-10 2023-07-28 Aurigene Oncology Ltd 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
KR20180021117A (ko) 2015-06-23 2018-02-28 칼리테라 바이오사이언시즈, 인코포레이티드 아르기나제 활성 억제를 위한 조성물 및 방법
US20170037303A1 (en) 2015-08-03 2017-02-09 Ecolab Usa Inc. Compositions and methods for delayed crosslinking in hydraulic fracturing fluids
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
CN108601767A (zh) 2015-10-05 2018-09-28 卡利泰拉生物科技公司 用谷氨酰胺酶抑制剂和免疫肿瘤学药剂的组合疗法
US20170112941A1 (en) 2015-10-13 2017-04-27 Symic Ip, Llc Ve-cadherin binding bioconjugate
AU2016344349B2 (en) * 2015-10-25 2022-05-19 Iview Therapeutics, Inc. Pharmaceutical formulations that form gel in situ
WO2017075363A1 (en) 2015-10-30 2017-05-04 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
US10745435B2 (en) 2015-11-16 2020-08-18 Cerecor, Inc. Nucleic acid prodrugs
JP6703408B2 (ja) * 2016-01-30 2020-06-03 国立大学法人 筑波大学 ポリイオンコンプレックスを有効成分とするドライアイ処置用組成物
MX2018009656A (es) 2016-02-12 2019-02-20 Astrazeneca Ab Piperidinas halo-sustituidas como moduladores de los receptores de orexinas.
US10087363B2 (en) * 2016-03-15 2018-10-02 Baker Hughes, A Ge Company, Llc Using borated galactomannan to enhance swelling of superabsorbents for fracturing applications
CA3021677C (en) 2016-04-22 2024-11-12 Viking Therapeutics, Inc. USE OF BETA-AGONISTS OF THYROID HORMONES
US10793590B2 (en) 2016-06-03 2020-10-06 President And Fellows Of Harvard College Antifungal compounds
US12274794B2 (en) 2016-07-06 2025-04-15 Orient Pharma Co., Ltd. Oral dosage form with drug composition, barrier layer and drug layer
WO2018013816A1 (en) 2016-07-15 2018-01-18 Ecolab USA, Inc. Compositions and methods for delayed crosslinking in hydraulic fracturing fluids
ES3062420T3 (en) 2016-08-25 2026-04-10 California Inst Of Techn Ascaroside treatment of eosinophilic esophagitis
WO2018049014A1 (en) 2016-09-07 2018-03-15 Trustees Of Tufts College Dash inhibitors, and uses related thereto
WO2018049094A1 (en) 2016-09-09 2018-03-15 The Regents Of The University Of California Estrogen receptor ligands, compositions and methods related thereto
TWI767937B (zh) 2016-09-09 2022-06-21 美商卡利泰拉生物科技公司 外核苷酸酶抑制劑及其使用方法
JP2019533643A (ja) 2016-09-14 2019-11-21 ヴァンダービルト ユニバーシティーVanderbilt University Bmpシグナル伝達の阻害、その化合物、組成物および使用
WO2018058029A1 (en) 2016-09-26 2018-03-29 Dana-Farber Cancer Institute, Inc. Chromobox protein inhibitors and uses thereof
EP3538111B1 (de) 2016-11-08 2022-01-19 Calithera Biosciences, Inc. Arginase-inhibitor-kombinationstherapien
SMT202100573T1 (it) 2016-12-22 2021-11-12 Calithera Biosciences Inc Composizioni e metodi per l'inibizione dell'attivita' dell'arginasi
US20200054643A1 (en) 2017-01-18 2020-02-20 Vanderbilt University Fused heterocyclic compounds as selective bmp inhibitors
MA47593A (fr) 2017-02-24 2020-01-01 Merck Patent Gmbh Dérivés de 1, 4, 6-trisubstitué-2-alkyl-1h-benzo[d]imidazole en tant qu'inhibiteurs de dihydroorotate oxygénase
DK3600270T3 (da) 2017-03-31 2023-07-10 Aurigene Oncology Ltd Forbindelser og sammensætninger til behandling af hæmatologiske lidelser
WO2018209288A1 (en) 2017-05-12 2018-11-15 Massachusetts Institute Of Technology Argonaute protein-double stranded rna complexes and uses related thereto
WO2018223032A1 (en) 2017-06-02 2018-12-06 Stealth Biotherapeutics Corp. Crystalline salt forms of sbt-20
WO2019018539A1 (en) 2017-07-19 2019-01-24 California Institute Of Technology PROCESSES FOR PREPARING COMPOUNDS CONTAINING BIS-TETRAHYDROISOQUINOLINE
JP2020536853A (ja) 2017-10-04 2020-12-17 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 転写因子sall4の小分子阻害およびその使用
IL273896B2 (en) 2017-10-11 2025-08-01 Aurigene Oncology Ltd Crystalline forms of 3-substituted 1,2,4-oxadiazole
KR20200072479A (ko) 2017-10-19 2020-06-22 사인패스 파마 인코포레이티드 채널병증을 야기하는 약물에 대한 DMPC, DMPG, DMPC/DMPG, LysoPG 및 LysoPC의 보호 효과
CA3079628A1 (en) 2017-10-31 2019-05-09 Curis, Inc. Compounds and compositions for treating hematological disorders
AU2018360386B2 (en) 2017-11-03 2023-11-09 Aurigene Oncology Limited Dual inhibitors of TIM-3 and PD-1 pathways
CN111386128A (zh) 2017-11-06 2020-07-07 奥瑞基尼探索技术有限公司 用于免疫调节的联合疗法
CA3085097A1 (en) 2017-12-22 2019-06-27 Medimmune Limited Small molecule modulators of the btb domain of keap1
TWI913170B (zh) 2018-02-21 2026-01-21 瑞士商愛爾康公司 基於脂質的眼用乳劑
WO2019178383A1 (en) 2018-03-14 2019-09-19 Vanderbilt University Inhibition of bmp signaling, compounds, compositions and uses thereof
WO2019175799A2 (en) 2018-03-14 2019-09-19 Aurigene Discovery Technologies Limited Method of modulating tigit and pd-1 signalling pathways using 1,2,4-oxadiazole compounds
BR112021001499A2 (pt) 2018-07-27 2021-04-27 California Institute Of Technology inibidores de cdk e usos dos mesmos
CN110787126A (zh) * 2018-08-03 2020-02-14 武汉武药科技有限公司 一种盐酸莫西沙星眼用凝胶及其制备方法
CA3111217A1 (en) 2018-09-05 2020-03-12 The General Hospital Corporation Methods of treating cytokine release syndrome
EP3849310A4 (de) 2018-09-12 2022-07-06 The Board of Regents of the University of Oklahoma Kombinationskrebstherapien
JP7504880B2 (ja) 2018-10-26 2024-06-24 ケロス セラピューティクス インコーポレイテッド Alk2阻害剤の結晶形
KR20210068591A (ko) 2018-10-31 2021-06-09 주식회사 인투셀 융합된 헤테로시클릭 벤조디아제핀 유도체 및 그의 용도
WO2020123449A1 (en) 2018-12-10 2020-06-18 The General Hospital Corporation Cromolyn esters and uses thereof
SG11202107614PA (en) 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
AU2020209216A1 (en) 2019-01-18 2021-08-26 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
JP2022525157A (ja) 2019-03-14 2022-05-11 アストラゼネカ・アクチエボラーグ 体重減少のためのラナベセスタット
TW202045631A (zh) 2019-03-15 2020-12-16 德商麥克專利有限公司 帶藍色之深黑色效果顏料
EP3978076A4 (de) 2019-06-03 2023-02-22 Irimajiri Therapeutics Inc. Zyklische amidverbindungen zur behandlung von tollwut und verfahren dafür
TWI757773B (zh) * 2019-06-28 2022-03-11 瑞士商愛爾康公司 眼用組成物
EP4017478A1 (de) * 2019-09-18 2022-06-29 Alcon Inc. Nass verpackte weiche hydrogel-augeneinlagen
EP4058434A1 (de) 2019-11-12 2022-09-21 Genzyme Corporation 6-gliedrige heteroarylaminosulfonamide zum behandeln von krankheiten und zuständen, die durch mangelnde cftr-aktivität vermittelt werden
WO2021113806A1 (en) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides and methods of use thereof
WO2021113809A1 (en) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides and methods of use thereof
US12545695B2 (en) 2019-12-16 2026-02-10 Unist (Ulsan National Institute Of Science And Technology) Compounds for inhibiting neovascularization factors and use thereof
JP2023515918A (ja) 2020-01-13 2023-04-17 デュレクト コーポレーション 不純物が低減された徐放性薬物送達システム及び関連の方法
KR102698413B1 (ko) 2020-05-05 2024-08-26 뉴베일런트, 아이엔씨. 헤테로방향족 거대환식 에터 화학치료제
IL297832A (en) 2020-05-05 2023-01-01 Nuvalent Inc Macrocyclic heteroaromatic chemotherapeutic agents
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods
EP4323356A1 (de) 2021-04-13 2024-02-21 Nuvalent, Inc. Aminosubstituierte heterocyclen zur behandlung von krebs mit egfr-mutationen
EP4396176A1 (de) 2021-09-03 2024-07-10 Genzyme Corporation Indolverbindungen und verwendungen davon bei der behandlung von zystischer fibrose
MX2024002519A (es) 2021-09-03 2024-05-27 Genzyme Corp Compuestos de indol y metodos de uso.
KR20240095536A (ko) 2021-10-01 2024-06-25 뉴베일런트, 아이엔씨. 헤테로방향족 매크로사이클릭 에테르 화합물을 사용한 고형 종양의 치료 방법
IL311444A (en) 2021-10-01 2024-05-01 Nuvalent Inc Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds
CN114191378A (zh) * 2021-11-23 2022-03-18 温州医科大学附属眼视光医院 一种地夸磷索缓释凝胶及其制备方法与应用
WO2023187672A1 (en) 2022-03-31 2023-10-05 Alcon Inc. Ophthalmic compositions
CA3245914A1 (en) 2022-04-07 2023-10-12 Nuvalent, Inc METHODS OF TREATMENT OF A SOLID TUMOR USING (19R)-5-CHLORO-3-ETHYL-16-FLUORO-10,19-DIMETHYL-20-OXA-3,4,10,11,23-PENTAAZAPENTACYCLO[19.3.1.02,6.08,12.013,18]PENTACOSA-1(24),2(6),4,8,11,13,15,17,21(25),22-DECAE-22-AMINE
JP2025512920A (ja) 2022-04-07 2025-04-22 ヌバレント, インク. ヘテロ芳香族大環状エーテル化合物の固体形態、薬学的組成物、及び調製
WO2023224961A1 (en) 2022-05-16 2023-11-23 Exelixis, Inc. Cancer therapy using a combination of a cdk7 inhibitor with an oral serd
IL318676A (en) 2022-08-04 2025-03-01 Dks Co Ltd Cyclic peptide derivative, method for producing same and composition
EP4568969A1 (de) 2022-08-12 2025-06-18 Nuvalent, Inc. Heteroaromatische makrocyclische etherverbindungen
WO2024036097A1 (en) 2022-08-12 2024-02-15 Nuvalent, Inc. Heteroaromatic macrocyclic ether compounds and isotopologues thereof
WO2024071371A1 (ja) 2022-09-30 2024-04-04 ユビエンス株式会社 複素環式化合物
JPWO2024071370A1 (de) 2022-09-30 2024-04-04
IL319638A (en) 2022-10-19 2025-05-01 Nuvalent Inc Chemotherapeutic agents of heteroaromatic macrocyclic esters
EP4613282A1 (de) 2022-11-04 2025-09-10 DKS Co. Ltd. Cyclische peptidderivatzusammensetzung zur behandlung oder prävention von verletzungen/krankheiten des zentralen nervensystems
CN120187444A (zh) 2022-11-04 2025-06-20 第一工业制药株式会社 用于处置或预防神经病理性疼痛和/或炎性疼痛的环状肽衍生物组合物
WO2024233456A1 (en) 2023-05-05 2024-11-14 The Board Of Regents Of The University Of Oklahoma Variants of adrenomedullin (am) and adrenomedullin 2/intermedin (am2/imd) and methods of use
WO2025042868A1 (en) 2023-08-23 2025-02-27 The Board Of Regents Of The University Of Oklahoma Combinations of heteroarotinoids and glycolytic inhibitors for use as cancer treatments
WO2025072117A1 (en) 2023-09-25 2025-04-03 Nuvalent, Inc. Heteroaromatic macrocyclic ether compounds and isotopologues thereof
WO2025072120A1 (en) 2023-09-25 2025-04-03 Nuvalent, Inc. Heteroaromatic macrocyclic ether compounds
WO2025085360A1 (en) 2023-10-16 2025-04-24 The Board Of Regents Of The University Of Oklahoma Heteroarotinoids and/or cdk4/6 inhibitors for treating human papillomavirus (hpv)-induced dysplasias, warts, and cancer in hpv-infected subjects
US20250277076A1 (en) 2024-03-04 2025-09-04 Alcon Inc. Mucoadhesive hydrophilic copolymers and uses thereof

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944427A (en) * 1970-04-06 1976-03-16 Itek Corporation Gelable and gelled compositions
US3843782A (en) 1971-07-26 1974-10-22 Flow Pharma Inc Eye solution and method of using same
US4136177A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Xanthan gum therapeutic compositions
US4136178A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Locust bean gum therapeutic compositions
US4136173A (en) 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
US4255415A (en) 1978-11-22 1981-03-10 Schering Corporation Polyvinyl alcohol ophthalmic gel
US4370325A (en) 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
US4436730A (en) 1979-06-25 1984-03-13 Polymer Technology Corporation Ionic opthalmic cellulose polymer solutions
US4624868A (en) * 1979-12-17 1986-11-25 Colgate-Palmolive Company Borated polysaccharide absorbents and absorbent products
US4323467A (en) 1980-11-24 1982-04-06 Syntex (U.S.A.) Inc. Contact lens cleaning, storing and wetting solutions
JPS57186733A (en) 1981-05-13 1982-11-17 Toyo Contact Lens Co Ltd Agent for use in contact lenses
US4362781A (en) * 1981-09-21 1982-12-07 Scott Paper Company Flushable premoistened wiper
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
FR2588189B1 (fr) * 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
US5457093A (en) 1987-09-18 1995-10-10 Ethicon, Inc. Gel formulations containing growth factors
US5188826A (en) 1988-02-08 1993-02-23 Insite Vision Incorporated Topical ophthalmic suspensions
US5192535A (en) 1988-02-08 1993-03-09 Insite Vision Incorporated Ophthalmic suspensions
US5607698A (en) 1988-08-04 1997-03-04 Ciba-Geigy Corporation Method of preserving ophthalmic solution and compositions therefor
US5126141A (en) 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
EP0386960A3 (de) 1989-03-07 1991-10-23 American Cyanamid Company Pharmazeutische Zusammensetzungen zur Verwendung als Wirkstoffabgabevehikel und/oder als Wundverband
US5145590A (en) 1990-01-16 1992-09-08 Bj Services Company Method for improving the high temperature gel stability of borated galactomannans
US5160643A (en) * 1990-01-16 1992-11-03 Bj Services Company Method for delaying the gellation of borated galactomannans with a delay additive such as glyoxal
US5082579A (en) * 1990-01-16 1992-01-21 Bj Services Company Method and composition for delaying the gellation of borated galactomannans
US5346703A (en) 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5376693A (en) 1990-08-07 1994-12-27 Mediventures Inc. Thermo-irreversible gel corneal contact lens formed in situ
US5077033A (en) 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5372732A (en) 1992-10-21 1994-12-13 Halliburton Company Delayed release borate crosslinking agent
WO1994010976A1 (en) 1992-11-16 1994-05-26 Ciba Vision Ag, Hettlingen Polyvinyl alcohol/borate ophthalmic drug delivery system
JPH06345653A (ja) 1993-06-08 1994-12-20 Asahi Chem Ind Co Ltd 点眼液
US5773025A (en) 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
US5603929A (en) 1994-11-16 1997-02-18 Alcon Laboratories, Inc. Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
US5972326A (en) 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
GB9603146D0 (en) 1996-02-15 1996-04-17 Innovative Tech Ltd Hydrogels
JP3989054B2 (ja) 1996-07-29 2007-10-10 株式会社メニコン コンタクトレンズ用洗浄材
JPH10221654A (ja) 1997-02-07 1998-08-21 Seiko Epson Corp コンタクトレンズ用溶液
DK0999825T3 (da) * 1997-07-29 2004-02-09 Alcon Lab Inc Oftalmiske sammensætninger indeholdende galactomannanpolymerer og borater
US6495608B1 (en) 1997-07-29 2002-12-17 Alcon Manufacturing, Ltd. Methods of performing surgery with galactomannan polymers and borate
CA2264290C (en) * 1997-07-29 2005-11-29 Alcon Laboratories, Inc. Conditioning solutions for contact lens care
WO2005060933A1 (en) * 2003-12-11 2005-07-07 Alcon, Inc. Ophthalmic compositions containing a polysaccharide/borate gelling system

Also Published As

Publication number Publication date
EP1348427B1 (de) 2008-04-09
ES2302881T3 (es) 2008-08-01
KR20010022286A (ko) 2001-03-15
CA2296080C (en) 2005-02-01
CN1302201A (zh) 2001-07-04
DE69839355D1 (de) 2008-05-21
KR100507984B1 (ko) 2005-08-17
ZA986533B (en) 1999-02-05
US6486138B1 (en) 2002-11-26
CN1544092A (zh) 2004-11-10
DK0999825T3 (da) 2004-02-09
DE69818675D1 (de) 2003-11-06
JP4673339B2 (ja) 2011-04-20
EP0999825A1 (de) 2000-05-17
ES2206965T3 (es) 2004-05-16
DK1348427T3 (da) 2008-06-30
BR9811574B1 (pt) 2010-11-30
DE69839355T2 (de) 2009-06-04
US6583124B2 (en) 2003-06-24
CN1762381B (zh) 2012-07-11
CN1229110C (zh) 2005-11-30
TW577751B (en) 2004-03-01
BR9811574A (pt) 2000-08-29
US6403609B1 (en) 2002-06-11
CN1762381A (zh) 2006-04-26
US6838449B2 (en) 2005-01-04
PT1348427E (pt) 2008-05-26
HK1055392A1 (en) 2004-01-09
LU92301I2 (fr) 2013-12-31
JP2003528797A (ja) 2003-09-30
JP3979783B2 (ja) 2007-09-19
WO1999006023A1 (en) 1999-02-11
US20020183280A1 (en) 2002-12-05
CY2013040I1 (el) 2015-11-04
EP0999825B1 (de) 2003-10-01
US7169767B2 (en) 2007-01-30
EP1348427A1 (de) 2003-10-01
AU737442B2 (en) 2001-08-16
CN100408100C (zh) 2008-08-06
AR013272A1 (es) 2000-12-13
PT999825E (pt) 2004-02-27
ATE391492T1 (de) 2008-04-15
AU8570598A (en) 1999-02-22
CY1110365T1 (el) 2015-04-29
CA2296080A1 (en) 1999-02-11
HK1026618A1 (en) 2000-12-22
CY2013040I2 (el) 2015-11-04
US20050075313A1 (en) 2005-04-07
DE69818675T2 (de) 2004-07-29
JP2007197461A (ja) 2007-08-09
US20030206970A1 (en) 2003-11-06
US20070098677A1 (en) 2007-05-03
TWI233801B (en) 2005-06-11

Similar Documents

Publication Publication Date Title
ATE250923T1 (de) Galaktomannanpolymere und borat enthaltende augenarzneimittel
BR9812128B8 (pt) Cateter iv e dispositivo de cateter
DE69820226T2 (de) Elektrooptische vorrichtung und elektronisches gerät
FR2798646B1 (fr) Dispositif de conditionnement et d'application
DE69732820D1 (de) Parallaxeschranke und Anzeigevorrichtung
ATE221162T1 (de) Datenübertragungssystem und bestandteile dafür
DE69530273D1 (de) Beleuchtungssystem und Anzeigevorrichtung
DE69839573D1 (de) Beleuchtungssystem und Projektionsanzeigegerät
DE69810484D1 (de) Hochglänzende und hochschlagfeste aromatische monovinylidenpolymere
DE69810231D1 (de) Silicon-Hydrogel-Polymere
DE69734431D1 (de) Transparante leitfolie, schwach reflektierende transparante leitfolie, und anzeige
DE69728434D1 (de) Ankoppelvorrichtung und flaschen
DE69907885D1 (de) Spritze und Spritzenkolben
DE69832657D1 (de) Empfangseinrichtungen und Empfangsverfahren
DE69928296D1 (de) Stabile FSH und FSH Varianten enthaltende Arzneimitteln
DE69835254D1 (de) Empfangseinrichtungen und Empfangsverfahren
DE69838463D1 (de) Optische Übertragungseinrichtung und optisches Übertragungssystem
DE69435247D1 (de) Bor-cluster enthaltende Nukleoside und Oligonukleoside
DE69840108D1 (de) Versuchsverfahren und vorrichtung
DE60042318D1 (de) Reflektierende lcd, halbdurchlässige reflektierende lcd und elektronische vorrichtung
DE69830435D1 (de) Räumlischer LichtModulator und Anzeige
DE69830132D1 (de) Ausgedehnte und transparente Beleuchtungseinrichtung
DE69818676D1 (de) Galaktomannanpolymere und borat enthaltende viskoelastische systeme mit regelbarer viskosität
DE69840431D1 (de) Programmierbare anzeigevorrichtung
DE69833889D1 (de) Plattengerät und Plattenhalterung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0999825

Country of ref document: EP