LU92780I9 - - Google Patents

Download PDF

Info

Publication number
LU92780I9
LU92780I9 LU92780C LU92780C LU92780I9 LU 92780 I9 LU92780 I9 LU 92780I9 LU 92780 C LU92780 C LU 92780C LU 92780 C LU92780 C LU 92780C LU 92780 I9 LU92780 I9 LU 92780I9
Authority
LU
Luxembourg
Application number
LU92780C
Other versions
LU92780I2 (fr
Inventor
Anirban Kindu
Louis H Bookbinder
Gregory L Frost
Original Assignee
Halozyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32962713&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU92780(I9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Halozyme Inc filed Critical Halozyme Inc
Publication of LU92780I2 publication Critical patent/LU92780I2/fr
Publication of LU92780I9 publication Critical patent/LU92780I9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
LU92780C 2003-03-05 2015-07-20 Trastuzumab et hyaluronidase humaine recombinante LU92780I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45236003P 2003-03-05 2003-03-05

Publications (2)

Publication Number Publication Date
LU92780I2 LU92780I2 (fr) 2015-09-21
LU92780I9 true LU92780I9 (fr) 2024-05-13

Family

ID=32962713

Family Applications (2)

Application Number Title Priority Date Filing Date
LU92780C LU92780I2 (fr) 2003-03-05 2015-07-20 Trastuzumab et hyaluronidase humaine recombinante
LU93138C LU93138I2 (fr) 2003-03-05 2016-07-04 Glycoprotéine d'hyaluronidase soluble (shasegp), son procédé de préparation, utilisations et compositions pharmaceutiques le comportant

Family Applications After (1)

Application Number Title Priority Date Filing Date
LU93138C LU93138I2 (fr) 2003-03-05 2016-07-04 Glycoprotéine d'hyaluronidase soluble (shasegp), son procédé de préparation, utilisations et compositions pharmaceutiques le comportant

Country Status (26)

Country Link
US (14) US7767429B2 (fr)
EP (7) EP2330213A1 (fr)
JP (3) JP4464395B2 (fr)
KR (4) KR101363658B1 (fr)
CN (2) CN1942588B (fr)
AT (1) ATE448323T1 (fr)
AU (2) AU2004218354B2 (fr)
BR (1) BRPI0408116B1 (fr)
CA (1) CA2517145C (fr)
CY (6) CY1109750T1 (fr)
DE (1) DE602004024041D1 (fr)
DK (4) DK2177620T3 (fr)
EA (1) EA009383B1 (fr)
ES (4) ES2532399T3 (fr)
FR (1) FR16C0030I1 (fr)
HU (2) HUE027661T2 (fr)
IL (2) IL170300A (fr)
LU (2) LU92780I2 (fr)
MX (1) MXPA05009429A (fr)
NZ (1) NZ542873A (fr)
PL (4) PL2405015T3 (fr)
PT (3) PT2177620E (fr)
SG (2) SG2012041067A (fr)
SI (4) SI2177620T1 (fr)
WO (1) WO2004078140A2 (fr)
ZA (1) ZA200507978B (fr)

Families Citing this family (295)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030212021A1 (en) * 2001-01-25 2003-11-13 Frost Gregory I. Myeloid colony stimulating factor and uses thereof
CA2508948A1 (fr) 2002-12-16 2004-07-15 Halozyme, Inc. Glycoproteine de chondroitinase (chasegp) humaine, son procede de preparation et compositions pharmaceutiques comprenant ladite glycoproteine
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
NZ542873A (en) 2003-03-05 2008-07-31 Halozyme Inc Soluble, neutral-active hyaluronidase activity glycoprotein (sHASEGP) that is produced with high yield in a mammalian expression system by introducing nucleic acids that lack a narrow region encoding amino acids in the carboxy terminus of the human PH20 cDNA
US20060104968A1 (en) * 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US20090123367A1 (en) * 2003-03-05 2009-05-14 Delfmems Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases
US7572613B2 (en) * 2004-06-25 2009-08-11 Klein Jeffrey A Drug delivery system for accelerated subcutaneous absorption
CN104689460B (zh) * 2004-12-30 2018-03-13 建新公司 用于关节内粘弹性补充的方案
CN103145842A (zh) 2005-06-30 2013-06-12 Abbvie公司 Il-12/p40结合蛋白
EP2500355A3 (fr) 2005-08-19 2012-10-24 Abbott Laboratories Immunoglobuline à double domaine variable et ses utilisations
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
NZ612578A (en) 2005-08-19 2014-11-28 Abbvie Inc Dual variable domain immunoglobin and uses thereof
EP1928905B1 (fr) 2005-09-30 2015-04-15 AbbVie Deutschland GmbH & Co KG Domaines de liaison de proteines de la famille proteinique des molecules de guidage repulsif (rgm), fragments fonctionnels de ces domaines et leur utilisation
US8168206B1 (en) * 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
HRP20140240T4 (hr) 2005-11-30 2017-02-24 Abbvie Inc. Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
SG170816A1 (en) 2006-03-31 2011-05-30 Qlt Plug Delivery Inc Drug delivery methods, structures, and compositions for nasolacrimal system
JP2010502224A (ja) 2006-09-08 2010-01-28 アボット・ラボラトリーズ インターロイキン１３結合タンパク質
UA94484C2 (uk) 2006-10-12 2011-05-10 Дженентек, Інк. Антитіла до лімфотоксину-альфа
US20080160003A1 (en) * 2006-10-31 2008-07-03 University Of Delaware Fertility Enhancement Using Lipid Carriers and Bioactive Molecules
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
RU2471867C2 (ru) * 2007-06-19 2013-01-10 Тамара П. Уваркина Гиалуронидаза и способ ее применения
US9011361B2 (en) * 2007-09-07 2015-04-21 Mati Therapeutics Inc. Lacrimal implant detection
JP2011517311A (ja) * 2007-11-06 2011-06-02 スチュアート エル ウェグ 麻酔薬組成物、製剤及び使用方法
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
SI4269578T1 (sl) 2008-03-06 2024-07-31 Halozyme, Inc. Sestava topne hialuronidaze
TWI489994B (zh) 2008-03-17 2015-07-01 Baxter Healthcare Sa 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
US20090311237A1 (en) * 2008-04-14 2009-12-17 Frost Gregory I Combination therapy using a soluble hyaluronidase and a bisphosphonate
KR20130116386A (ko) 2008-04-14 2013-10-23 할로자임, 아이엔씨 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
SG190572A1 (en) 2008-04-29 2013-06-28 Abbott Lab Dual variable domain immunoglobulins and uses thereof
EP2116556B1 (fr) 2008-05-09 2016-03-23 AbbVie Deutschland GmbH & Co KG Anticorps contre récepteur de produit terminal de glycosylation (RAGE) et utilisations associées
TW201006485A (en) 2008-06-03 2010-02-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
CA2726087A1 (fr) 2008-06-03 2009-12-10 Tariq Ghayur Immunoglobulines a deux domaines variables et leurs utilisations
CN102149825B (zh) 2008-07-08 2015-07-22 Abbvie公司 前列腺素e2双重可变结构域免疫球蛋白及其用途
TW201014602A (en) 2008-07-08 2010-04-16 Abbott Lab Prostaglandin E2 binding proteins and uses thereof
WO2010009129A2 (fr) * 2008-07-15 2010-01-21 Genentech, Inc. Méthodes de traitement de maladies auto-immunes utilisant des anticorps cd4
ES2413492T3 (es) * 2008-10-14 2013-07-16 Burgard, Gunther, Dr. Uso de hialuronidasa para la prevención o el tratamiento de la hipertensión arterial
GB0819883D0 (en) 2008-10-29 2008-12-03 Azyme Res As Product and uses
AU2013202000B2 (en) * 2008-12-09 2015-07-30 Halozyme, Inc. Extended soluble PH20 polypeptides and uses thereof
EA022752B1 (ru) 2008-12-09 2016-02-29 Галозим, Инк. Длинные растворимые полипептиды рн20 и их использование
US20100209558A1 (en) * 2009-02-19 2010-08-19 General Nutrition Corporation Dietary ingredient with enhanced bioavailability
TWI541021B (zh) 2009-03-05 2016-07-11 艾伯維有限公司 Ｉｌ－１７結合蛋白
EP2403523A1 (fr) * 2009-03-06 2012-01-11 Halozyme, Inc. Mutants thermosensibles de métalloprotéase matricielle 1 et leurs utilisations
US8283162B2 (en) 2009-03-10 2012-10-09 Abbott Laboratories Antibodies relating to PIVKAII and uses thereof
ES2385251B1 (es) 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge Adenovirus oncolíticos para el tratamiento del cáncer.
DE102009003291A1 (de) * 2009-05-20 2010-12-30 Henkel Ag & Co. Kgaa Kosmetische Zusammensetzung und Verformungsverfahren für keratinische Fasern
WO2010138918A1 (fr) * 2009-05-29 2010-12-02 Pacira Pharmaceuticals, Inc. Hyaluronidase comme adjuvant pour augmenter le volume d'injection et la dispersion de vésicules membranaires synthétiques de grand diamètre contenant un agent thérapeutique
US20100316639A1 (en) 2009-06-16 2010-12-16 Genentech, Inc. Biomarkers for igf-1r inhibitor therapy
EP2448574A4 (fr) * 2009-06-29 2013-04-17 Univ Singapore Synthèse et utilisation d'antipaludéens marqués par fluorophore
US8263581B2 (en) 2009-07-03 2012-09-11 Jdp Therapeutics, Inc. Non-sedating antihistamine injection formulations and methods of use thereof
US8513259B2 (en) 2009-07-03 2013-08-20 Jdp Therapeutics, Inc. Non-sedating antihistamine injection formulations and methods of use thereof
US9345661B2 (en) 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
WO2011028811A2 (fr) 2009-09-01 2011-03-10 Abbott Laboratories Immunoglobulines à double domaine variable et leurs utilisations
AR078161A1 (es) * 2009-09-11 2011-10-19 Hoffmann La Roche Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
HUE028832T2 (en) 2009-09-17 2017-01-30 Baxalta Inc Stable co-formulation of hyaluronidase and immunoglobulin, as well as a process for its preparation
BR112012008833A2 (pt) 2009-10-15 2015-09-08 Abbott Lab imunoglobulinas de dominio variavel duplo e usos das mesmas
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
WO2011053707A1 (fr) 2009-10-31 2011-05-05 Abbott Laboratories Anticorps pour récepteur pour produits terminaux de glycation avancée (rage) et utilisations de ceux-ci
MX2012006560A (es) 2009-12-08 2012-10-05 Abbott Gmbh & Co Kg Anticuerpos monoclonales contra la proteina rgm a para utilizarse en el tratamiento de degeneracion de capa de fibra de nervio retinal.
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
AR081246A1 (es) 2010-05-14 2012-07-18 Abbott Lab Proteinas de union a il-1
WO2012006500A2 (fr) 2010-07-08 2012-01-12 Abbott Laboratories Anticorps monoclonaux contre la protéine de capside du virus de l'hépatite c
UY33492A (es) 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
WO2012012300A2 (fr) 2010-07-20 2012-01-26 Halozyme, Inc. Effets secondaires indésirables associés à l'administration d'un agent anti-hyaluronane et procédés pour améliorer ou prévenir ces effets secondaires
US9120862B2 (en) 2010-07-26 2015-09-01 Abbott Laboratories Antibodies relating to PIVKA-II and uses thereof
EP3252072A3 (fr) 2010-08-03 2018-03-14 AbbVie Inc. Immunoglobuline à double domaine variable et ses utilisations
EP3533803B1 (fr) 2010-08-14 2021-10-27 AbbVie Inc. Anticorps anti-bêta-amyloïde
JP2013539364A (ja) 2010-08-26 2013-10-24 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリンおよびその使用
MX349622B (es) 2010-09-08 2017-08-07 Halozyme Inc Metodos para evaluar e identificar o evolucionar proteinas terapeuticas condicionalmente activas.
US8740982B2 (en) 2010-10-26 2014-06-03 Kyphon Sarl Devices containing a chemonucleolysis agent and methods for treating an intervertebral disc or spinal arachnoiditis
US9414930B2 (en) 2010-10-26 2016-08-16 Kyphon SÀRL Activatable devices containing a chemonucleolysis agent
US8404268B2 (en) 2010-10-26 2013-03-26 Kyphon Sarl Locally targeted anti-fibrotic agents and methods of use
JP6194248B2 (ja) 2010-10-28 2017-09-06 パシラ ファーマシューティカルズ インコーポレーテッド 非ステロイド性抗炎症薬の徐放性処方物
KR20190120439A (ko) 2010-11-08 2019-10-23 제넨테크, 인크. 피하 투여용 항―ｉｌ―6 수용체 항체
PE20141060A1 (es) 2010-12-21 2014-09-26 Abbvie Inc Inmunoglobulinas de dominio variable dual biespecificas de il-1 alfa y beta y su uso
US20120244174A1 (en) * 2011-01-31 2012-09-27 Intellect Neurosciences Inc. Treatment of tauopathies
WO2012109387A1 (fr) 2011-02-08 2012-08-16 Halozyme, Inc. Composition et formulation lipidique d'une enzyme dégradant le hyaluronane et son utilisation pour le traitement de l'hyperplasie bénigne de la prostate
NZ618331A (en) 2011-06-17 2016-04-29 Halozyme Inc Stable formulations of a hyaluronan-degrading enzyme
CA2839512C (fr) 2011-06-17 2018-01-02 Halozyme, Inc. Procedes de perfusion d'insuline sous-cutanee continue utilisant une enzyme de degradation de l'hyaluronane
US20130011378A1 (en) 2011-06-17 2013-01-10 Tzung-Horng Yang Stable formulations of a hyaluronan-degrading enzyme
SG10201505454SA (en) 2011-07-13 2015-09-29 Abbvie Inc Methods and compositions for treating asthma using anti-il-13 antibodies
WO2013040501A1 (fr) 2011-09-16 2013-03-21 Pharmathene, Inc. Compositions et combinaisons d'accepteurs biologiques organophosphorés et d'enzymes dégradant le hyaluronane, et leurs utilisations
JP6162707B2 (ja) 2011-10-24 2017-07-12 ハロザイム インコーポレイテッド 抗ヒアルロナン剤治療のためのコンパニオン診断およびその使用方法
HK1200322A1 (en) 2011-10-24 2015-08-07 Abbvie Inc. Immunobinders directed against sclerostin
RU2014121043A (ru) 2011-10-24 2015-12-10 Эббви Инк. Биспецифические иммуносвязывающие средства, направленные против tnf и il-17
CA3204283A1 (fr) 2011-12-14 2013-06-20 AbbVie Deutschland GmbH & Co. KG Composition et methode pour le diagnostic et le traitement de troubles lies au fer
CA2855570A1 (fr) 2011-12-14 2013-06-20 AbbVie Deutschland GmbH & Co. KG Composition et methode pour le diagnostic et le traitement de troubles lies au fer
WO2013102144A2 (fr) 2011-12-30 2013-07-04 Halozyme, Inc. Variants du polypeptide ph20, formulations en contenant et leurs utilisations
TW201333035A (zh) 2011-12-30 2013-08-16 Abbvie Inc 針對ｉｌ－１３及／或ｉｌ－１７之雙特異性結合蛋白
EP3369746A1 (fr) 2012-01-27 2018-09-05 AbbVie Deutschland GmbH & Co KG Composition et procédé pour le diagnostic et le traitement de maladies associées à la dégénérescence des neurites
CN108686203A (zh) 2012-04-04 2018-10-23 哈洛齐梅公司 使用抗透明质酸剂和肿瘤靶向紫杉烷的组合疗法
EP2843051B1 (fr) 2012-04-23 2018-06-06 GeneFrontier Corporation Anticorps anti-cd69 humain, et application médicale de celui-ci
UY34905A (es) 2012-07-12 2014-01-31 Abbvie Inc Proteínas de unión a il-1
EP2877589B1 (fr) 2012-07-26 2024-03-06 Momenta Pharmaceuticals, Inc. Glycoprotéines ayant des propriétés anti-inflammatoires
WO2014062856A1 (fr) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxie et hyaluronane et leurs marqueurs pour le diagnostic et la surveillance de maladies et de pathologies, et méthodes associées
TW202037609A (zh) 2012-11-01 2020-10-16 美商艾伯維有限公司 抗-vegf/dll4雙重可變區域免疫球蛋白及其用途
KR101454646B1 (ko) * 2012-11-05 2014-10-27 (주)한국비엠아이 히알루로니다아제의 안정화 제제 및 이를 포함하는 액상제제
US9845364B2 (en) 2012-11-09 2017-12-19 Genefrontier Corporation Anti-ADAM28 antibody for treating cancer
WO2014107745A1 (fr) 2013-01-07 2014-07-10 Halozyme, Inc. Métalloprotéases matricielles mutantes sensibles aux métaux et leurs utilisations
PE20151747A1 (es) 2013-03-14 2015-12-18 Univ Massachusetts Metodo para inhibir cataratas y presbicia
US9469686B2 (en) 2013-03-15 2016-10-18 Abbott Laboratories Anti-GP73 monoclonal antibodies and methods of obtaining the same
WO2014144280A2 (fr) 2013-03-15 2014-09-18 Abbvie Inc. Protéines de liaison spécifiques à domaines variables doubles dirigées contre il -1β et/ou il -17
TWI476203B (zh) 2013-03-18 2015-03-11 Ind Tech Res Inst 醣類的分離方法
KR20150138219A (ko) 2013-04-03 2015-12-09 세다르스-신나이 메디칼 센터 히알루로난 및 히알루로니다제 활성의 조절에 의한 염증성 병태의 치료
WO2014186310A1 (fr) 2013-05-13 2014-11-20 Momenta Pharmaceuticals, Inc. Méthodes de traitement de la neurodégénérescence
US10183988B2 (en) 2013-06-07 2019-01-22 Duke University Anti-Complement factor H antibodies
US10782290B2 (en) 2013-06-11 2020-09-22 National Center Of Neurology And Psychiatry Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy
WO2015002969A1 (fr) 2013-07-03 2015-01-08 City Of Hope Associations anti-cancer
TW201534726A (zh) 2013-07-03 2015-09-16 Halozyme Inc 熱穩定ｐｈ２０玻尿酸酶變異體及其用途
CA2920835A1 (fr) 2013-08-20 2015-02-26 Anutra Medical, Inc. Systeme de remplissage de seringue et procede associe
US9968623B2 (en) * 2013-08-29 2018-05-15 Lanny Leo Johnson Prepackaged sterile syringe or containers with various substance concentrations with or without bioactive reagent
IL312865B2 (en) 2013-09-11 2025-06-01 Eagle Biologics Inc Liquid protein formulations containing viscosity-lowering agents
PT3057992T (pt) 2013-10-15 2024-07-10 Univ Keio Anticorpo humano contra espécies de adamts do tipo agrecanase para terapêuticas de doenças relacionadas com agrecanase
WO2015057622A1 (fr) 2013-10-16 2015-04-23 Momenta Pharmaceuticals, Inc. Glycoprotéines sialylées
CA2931978A1 (fr) 2013-12-02 2015-06-11 Abbvie Inc. Compositions et methodes pour traiter l'arthrose
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
US9732154B2 (en) 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
US20150291689A1 (en) 2014-03-09 2015-10-15 Abbvie, Inc. Compositions and Methods for Treating Rheumatoid Arthritis
AR099812A1 (es) 2014-03-21 2016-08-17 Abbvie Inc Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr
US10117886B2 (en) 2014-05-30 2018-11-06 Hao Cheng Hyaluronidase and a low density second PEG layer on the surface of therapeutic-encapsulated nanoparticles to enhance nanoparticle diffusion and circulation
USD750768S1 (en) 2014-06-06 2016-03-01 Anutra Medical, Inc. Fluid administration syringe
USD774182S1 (en) 2014-06-06 2016-12-13 Anutra Medical, Inc. Anesthetic delivery device
USD763433S1 (en) 2014-06-06 2016-08-09 Anutra Medical, Inc. Delivery system cassette
US20160002326A1 (en) 2014-06-10 2016-01-07 Abbvie Inc. Compositions and methods for treating rheumatoid arthritis
AU2015289619C1 (en) * 2014-07-16 2021-01-07 New York University Use of hyaluronidase for treatment of muscle stiffness
PT3186281T (pt) 2014-08-28 2019-07-10 Halozyme Inc Terapia de combinação com uma enzima de degradação de hialuronano e um inibidor de pontos de verificação imunológica
PH12017500442B1 (en) 2014-09-09 2023-05-24 Janssen Biotech Inc Combination therapies with anti-cd38 antibodies
JP6648142B2 (ja) * 2014-09-18 2020-02-14 コンドロネスト・ソシエテ・アノニム グリコサミノグリカンおよびタンパク質を含む組成物
AU2015325055B2 (en) 2014-10-01 2021-02-25 Eagle Biologics, Inc. Polysaccharide and nucleic acid formulations containing viscosity-lowering agents
BR112017007765B1 (pt) 2014-10-14 2023-10-03 Halozyme, Inc Composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo
CN107406506A (zh) 2014-12-04 2017-11-28 詹森生物科技公司 用于治疗急性髓系白血病的抗cd38抗体
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
WO2016137471A1 (fr) * 2015-02-26 2016-09-01 Nantpharma, Llc Procédé pour améliorer la qualité de l'héparine
US9981021B1 (en) 2015-04-09 2018-05-29 Kinetiq, Inc. Subcutaneous therapeutic enzyme formulations, uses, and methods for generating thereof
EA201792546A1 (ru) 2015-05-20 2018-04-30 Янссен Байотек, Инк. Антитела к cd38 для лечения амилоидоза легких цепей и прочих cd38-положительных гематологических злокачественных опухолей
CN107810198B (zh) 2015-05-29 2021-09-03 艾伯维公司 抗cd40抗体及其用途
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
IL256242B2 (en) * 2015-06-22 2024-09-01 Janssen Biotech Inc Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors
EA037548B1 (ru) 2015-06-24 2021-04-12 Янссен Байотек, Инк. Иммуномодуляция и лечение солидных опухолей антителами, которые специфически связывают cd38
US20170044265A1 (en) 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
JP2018526404A (ja) 2015-09-11 2018-09-13 アッヴィ・インコーポレイテッド 再発型の多発性硬化症を治療するための方法
US10781261B2 (en) 2015-11-03 2020-09-22 Janssen Biotech, Inc. Subcutaneous formulations of anti-CD38 antibodies and their uses
CA3004152C (fr) * 2015-11-03 2024-04-16 Janssen Biotech, Inc. Formulations sous-cutanee d'anticorps anti-cd38 et leurs utilisations
MX376641B (es) 2015-11-13 2025-03-07 Univ Massachusetts Moléculas bifuncionales que contienen peg para uso en la inhibición de cataratas y presbicia.
ITUB20159209A1 (it) * 2015-12-21 2017-06-21 Fidia Farm Spa Nanosistemi per il trasporto controllato di molecole attive a fini diagnostici, prognostici e terapeutici
US10493247B2 (en) 2016-03-15 2019-12-03 Medtronic Holding Company Sàrl Devices for delivering a chemical denervation agent and methods of use
WO2017161206A1 (fr) 2016-03-16 2017-09-21 Halozyme, Inc. Conjugués contenant des anticorps à activité conditionnelle ou des fragments de liaison à un antigène associés, et procédés d'utilisation
WO2017165464A1 (fr) 2016-03-21 2017-09-28 Elstar Therapeutics, Inc. Molécules multispécifiques et multifonctionnelles et leurs utilisations
EP3464372A1 (fr) 2016-06-01 2019-04-10 AbbVie Inc. Anticorps antagonistes de la molécule de guidage anti-répulsion a (rgma) pour le traitement de lésions et de douleurs de la moelle épinière
AU2017279550A1 (en) 2016-06-08 2019-01-03 Abbvie Inc. Anti-B7-H3 antibodies and antibody drug conjugates
JP2019524651A (ja) 2016-06-08 2019-09-05 アッヴィ・インコーポレイテッド 抗ｃｄ９８抗体及び抗体薬物コンジュゲート
WO2017214322A1 (fr) 2016-06-08 2017-12-14 Abbvie Inc. Anticorps anti-b7-h3 et conjugués anticorps-médicaments
US20190233533A1 (en) 2016-06-28 2019-08-01 Umc Utrecht Holding B.V. Treatment Of IgE-Mediated Diseases With Antibodies That Specifically Bind CD38
KR102480965B1 (ko) 2016-09-13 2022-12-26 알레간 인코포레이티드 안정화된 비단백질 클로스트리듐 독소 조성물
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
KR102618948B1 (ko) 2016-11-17 2023-12-27 이오반스 바이오테라퓨틱스, 인크. 잔유 종양 침윤 림프구 및 그의 제조 및 사용 방법
US20190350992A1 (en) * 2016-11-17 2019-11-21 Vcn Biosciences Sl Use of viral vectors in the treatment of retinoblastoma
EP3541815A4 (fr) 2016-11-18 2020-07-15 Pacira Pharmaceuticals, Inc. Formulations de liposomes multivésiculaires à microparticules de complexe de méloxicam de zinc et leurs procédés de fabrication
EP3544628A4 (fr) 2016-11-23 2020-11-18 Immunoah Therapeutics, Inc. Protéines de liaison à 4-1bb et leurs utilisations
TW202508629A (zh) 2017-01-17 2025-03-01 美商建南德克公司 皮下her2抗體調配物
EP3601355A1 (fr) 2017-03-31 2020-02-05 Bristol-Myers Squibb Company Procédés de traitement de tumeur
WO2018203545A1 (fr) 2017-05-02 2018-11-08 国立研究開発法人国立精神・神経医療研究センター Procédé de prédiction et d'évaluation d'un effet thérapeutique dans des maladies associées à il-6 et à des neutrophiles
US10865238B1 (en) 2017-05-05 2020-12-15 Duke University Complement factor H antibodies
RU2651756C1 (ru) * 2017-05-10 2018-04-23 Федеральное государственное бюджетное образовательное учреждение Высшего Образования Кубанский Государственный Медицинский Университет Министерства Здравоохранения Российской Федерации, КубГМУ Препарат для предотвращения образования глиальных рубцов
CN111247169A (zh) 2017-10-15 2020-06-05 百时美施贵宝公司 治疗肿瘤的方法
MA50514A (fr) 2017-10-31 2020-09-09 Janssen Biotech Inc Méthodes de traitement du myélome multiple à haut risque
WO2019090330A1 (fr) 2017-11-06 2019-05-09 Bristol-Myers Squibb Company Méthodes de traitement d'une tumeur
US12042528B2 (en) 2017-12-29 2024-07-23 The Trustees Of Columbia University In The City Of New York Hyaluronidase for the prevention, treatment, reduction and/or abolishment of cerebral edema and intracranial pressure
US12247060B2 (en) 2018-01-09 2025-03-11 Marengo Therapeutics, Inc. Calreticulin binding constructs and engineered T cells for the treatment of diseases
ES2973728T3 (es) 2018-03-13 2024-06-24 Fundacion Para La Investigacion Biomedica Del Hospital Univ La Paz Anticuerpo anti-CXCR4 combinado con linfocitos citolíticos naturales activados y expandidos para inmunoterapia contra el cáncer
EP3765517A1 (fr) 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Molécules multifonctionnelles se liant à calréticuline et utilisations associees
EP3765516A2 (fr) 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Molécules multifonctionnelles et utilisations associées
WO2019182745A1 (fr) 2018-03-19 2019-09-26 Bryn Pharma, LLC Formulations pour la pulvérisation d'épinéphrine
EP3768715A1 (fr) 2018-03-23 2021-01-27 Bristol-Myers Squibb Company Anticorps contre mica et/ou micb et leurs utilisations
KR20200139724A (ko) 2018-03-30 2020-12-14 브리스톨-마이어스 스큅 컴퍼니 종양을 치료하는 방법
EP3774903A1 (fr) 2018-04-04 2021-02-17 Bristol-Myers Squibb Company Anticorps anti-cd27 et leurs utilisations
PL3681500T3 (pl) 2018-04-24 2022-08-01 Allergan, Inc. Zastosowanie chlorowodorku pilokarpiny w leczeniu starczowzroczności
UA130542C2 (uk) 2018-05-16 2026-03-18 Янссен Байотек, Інк. Антитіло до cd38 та терапевтичний засіб, який перенаправляє т-клітини, для лікування множинної мієломи у суб'єкта
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
JP7609771B2 (ja) * 2018-06-01 2025-01-07 エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント タンパク質と細胞のグリカン分析
WO2020003210A1 (fr) 2018-06-29 2020-01-02 Kangwon National University University-Industry Cooperation Foundation Anticorps anti-l1cam et leurs utilisations
CA3105448A1 (fr) 2018-07-03 2020-01-09 Elstar Therapeutics, Inc. Molecules d'anticorps anti-tcr et leurs utilisations
MX2020009824A (es) 2018-07-25 2021-01-15 Alteogen Inc Nuevas variantes de hialuronidasa y composicion farmaceutica que comprende la misma.
JP2022512642A (ja) 2018-10-09 2022-02-07 ブリストル－マイヤーズ スクイブ カンパニー がんを治療するための抗ＭｅｒＴＫ抗体
KR20210077725A (ko) 2018-10-17 2021-06-25 얀센 바이오테크 인코포레이티드 항-cd38 항체의 피하 투여를 제공하는 방법
WO2020086724A1 (fr) 2018-10-23 2020-04-30 Bristol-Myers Squibb Company Méthodes de traitement de tumeur
US20210388070A1 (en) * 2018-10-30 2021-12-16 Alexion Pharmaceuticals, Inc. Co-administration of a hyaluronidase and anti-c5 antibody for treatment of complement-associated conditions
EA202191352A1 (ru) 2018-11-13 2021-08-11 Янссен Байотек, Инк. Контроль содержания микроэлементов-металлов во время продукции антител к cd38
CN109679823B (zh) * 2018-11-19 2022-03-15 江苏汇先医药技术有限公司 一种用于生物分子、细胞或细菌的捕获材料及捕获筛
EP3927431A1 (fr) 2019-02-21 2021-12-29 Marengo Therapeutics, Inc. Molécules d'anticorps anti-tcr et leurs utilisations
GB2599228B (en) 2019-02-21 2024-02-07 Marengo Therapeutics Inc Multifunctional molecules that bind to T cell related cancer cells and uses thereof
CN119039441A (zh) 2019-02-21 2024-11-29 马伦戈治疗公司 与nkp30结合的抗体分子及其用途
KR102650991B1 (ko) * 2019-03-25 2024-03-27 (주)알테오젠 인간 히알루로니다제 ph20의 변이체와 약물을 포함하는 피하투여용 약학 조성물
KR20210146348A (ko) 2019-03-28 2021-12-03 브리스톨-마이어스 스큅 컴퍼니 종양을 치료하는 방법
WO2020198676A1 (fr) 2019-03-28 2020-10-01 Bristol-Myers Squibb Company Méthodes de traitement de tumeur
WO2020201828A1 (fr) 2019-04-05 2020-10-08 Tauc3 Biologics Limited Anticorps anti-tauc3 et leurs utilisations
CN119570901A (zh) * 2019-05-07 2025-03-07 建新公司 前药组合物中药物浓度的量化方法
US20220193149A1 (en) * 2019-05-16 2022-06-23 City Of Hope Compositions and methods for targeting tumor-associated extracellular matrix components to improve drug delivery
AU2020285197B2 (en) * 2019-05-24 2026-04-09 Glytech, Inc. Novel artificial protein catalyst
US20220363760A1 (en) 2019-05-30 2022-11-17 Bristol-Myers Squibb Company Multi-tumor gene signature for suitability to immuno-oncology therapy
KR20220016155A (ko) 2019-05-30 2022-02-08 브리스톨-마이어스 스큅 컴퍼니 면역-종양학 (i-o) 요법에 적합한 대상체를 확인하는 방법
WO2020243570A1 (fr) 2019-05-30 2020-12-03 Bristol-Myers Squibb Company Signature de localisation cellulaire et polythérapie
WO2021050789A1 (fr) 2019-09-10 2021-03-18 Obsidian Therapeutics, Inc. Protéines de fusion de ca2-il15 pour une régulation accordable
KR20220066950A (ko) 2019-09-25 2022-05-24 브리스톨-마이어스 스큅 컴퍼니 암 요법을 위한 복합 바이오마커
EP4017524A4 (fr) * 2019-10-15 2022-09-21 Standard of Care Corporation Compositions comprenant de l'hyaluronidase et/ou de la collagénase et/ou de la 4-méthylumbelliférone (4-mu) et procédés de traitement l'utilisant
WO2021092220A1 (fr) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Procédés d'identification d'un sujet atteint d'une tumeur appropriée pour une thérapie par inhibiteur de point de contrôle
WO2021092221A1 (fr) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Procédés d'identification d'un sujet atteint d'une tumeur appropriée pour une thérapie par inhibiteur de point de contrôle
US20220411499A1 (en) 2019-11-08 2022-12-29 Bristol-Myers Squibb Company LAG-3 Antagonist Therapy for Melanoma
KR20220113414A (ko) 2019-12-09 2022-08-12 제넨테크, 인크. 항-pd-l1 항체 제제
EP4084821A4 (fr) 2020-01-03 2024-04-24 Marengo Therapeutics, Inc. Molécules multifonctionnelles se liant à cd33 et utilisations associées
AU2020416273A1 (en) 2020-01-03 2022-07-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
US20230190881A1 (en) 2020-02-17 2023-06-22 Biotest Ag Subcutaneous administration of factor viii
AU2021244200A1 (en) 2020-03-23 2022-11-24 Bristol-Myers Squibb Company Anti-CCR8 antibodies for treating cancer
CN111529685A (zh) * 2020-04-21 2020-08-14 厦门诺康得生物科技有限公司 抗呼吸道病毒感染的鼻腔喷雾制剂
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
JP2023532122A (ja) 2020-06-29 2023-07-26 ジェネンテック， インコーポレイテッド ペルツズマブにトラスツズマブを加えた固定用量配合剤
JP2023533813A (ja) 2020-07-14 2023-08-04 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 一定用量配合剤のアッセイ
IL299205A (en) * 2020-07-17 2023-02-01 Geron Corp Subcutaneous telomerase inhibitor preparations and methods of using them
US12221638B2 (en) * 2020-08-07 2025-02-11 Alteogen Inc. Method for producing recombinant hyaluronidase
CN111759732B (zh) * 2020-08-12 2024-12-06 河南省人民医院 一种用于外周血造血干细胞冻存的多通道连接管路及方法
AU2021331075A1 (en) 2020-08-26 2023-04-06 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
GB2616354A (en) 2020-08-26 2023-09-06 Marengo Therapeutics Inc Methods of detecting TRBC1 or TRBC2
IL300813A (en) 2020-08-28 2023-04-01 Bristol Myers Squibb Co LAG-3 antagonist therapy for hepatocellular carcinoma
AU2021334361A1 (en) 2020-08-31 2023-05-11 Bristol-Myers Squibb Company Cell localization signature and immunotherapy
CN112168838A (zh) * 2020-10-23 2021-01-05 中国科学院动物研究所 透明质酸及其盐的治疗用途
KR20230093282A (ko) 2020-10-23 2023-06-27 브리스톨-마이어스 스큅 컴퍼니 폐암에 대한 lag-3 길항제 요법
US20220133861A1 (en) * 2020-10-30 2022-05-05 Standard Of Care Corporation Hyaluronidase compositions and methods of using same to treat edema
CA3196877A1 (fr) 2020-11-17 2022-05-27 Janssen Sciences Ireland Unlimited Company Traitement ou prevention d'une maladie ou d'un trouble
WO2022109555A1 (fr) 2020-11-17 2022-05-27 Janssen Sciences Ireland Unlimited Company Traitement ou prévention d'une infection par le vih
MX2023005758A (es) * 2020-11-17 2023-07-28 Janssen Sciences Ireland Unlimited Co Tratamiento o prevención de la infección por vih.
WO2022120179A1 (fr) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Signatures géniques multi-tumorales et leurs utilisations
JP2024501029A (ja) 2020-12-28 2024-01-10 ブリストル－マイヤーズ スクイブ カンパニー Ｐｄ１／ｐｄ－ｌ１抗体の皮下投与
US20220233693A1 (en) 2020-12-28 2022-07-28 Bristol-Myers Squibb Company Antibody Compositions and Methods of Use Thereof
AR124681A1 (es) 2021-01-20 2023-04-26 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
US20220275090A1 (en) 2021-02-22 2022-09-01 Janssen Biotech, Inc. Combination Therapies with Anti-CD38 Antibodies and PARP or Adenosine Receptor Inhibitors
CN114350639B (zh) * 2021-03-05 2023-06-02 华熙生物科技股份有限公司 一种密码子优化的透明质酸水解酶基因及其表达
CN113025599B (zh) * 2021-04-02 2023-09-12 重庆科润生物医药研发有限公司 一种重组溶组织梭菌i型胶原酶及其制备方法和应用
EP4314068A1 (fr) 2021-04-02 2024-02-07 The Regents Of The University Of California Anticorps dirigés contre un cdcp1 clivé et leurs utilisations
TW202305009A (zh) 2021-04-08 2023-02-01 美商默沙東有限責任公司 以皮下投予抗pd1抗體治療癌症之方法
WO2022216993A2 (fr) 2021-04-08 2022-10-13 Marengo Therapeutics, Inc. Molécules multifonctionnelles se liant au tcr et leurs utilisations
US20220332822A1 (en) 2021-04-16 2022-10-20 Tiziana Life Sciences Plc Subcutaneous administration of antibodies for the treatment of disease
TW202308689A (zh) 2021-04-21 2023-03-01 美商健生生物科技公司 高濃度的雙特異性抗體調配物
WO2022251645A1 (fr) 2021-05-27 2022-12-01 Steiner Ventures Llc Composition d'hyaluronidase pour administration intraveineuse et son procédé d'utilisation
CN115671267A (zh) 2021-07-23 2023-02-03 上海宝济药业有限公司 一种皮下抗生素药物组合物
KR20240040104A (ko) 2021-08-02 2024-03-27 아르젠엑스 비브이 피하 단위 투여 형태
CN117693362A (zh) * 2021-08-02 2024-03-12 甘李药业股份有限公司 含有抗il-4r抗体的稳定制剂
KR20240055077A (ko) 2021-09-14 2024-04-26 다케다 야쿠힌 고교 가부시키가이샤 히알루로니데이스를 이용한 농축된 항체 제형의 촉진된 전달
CA3224890A1 (fr) 2021-10-29 2023-05-04 Bristol-Myers Squibb Company Therapie par antagoniste de lag-3 pour cancer hematologique
JP2024541973A (ja) * 2021-10-29 2024-11-13 アルテオジェン・インコーポレイテッド ヒトヒアルロニダーゼｐｈ２０及び薬物を含む医薬組成物
AU2022380155A1 (en) 2021-11-03 2024-06-20 Janssen Biotech, Inc. Corticosteriod reduction in treatment with anti-cd38 antibodies
MX2024005392A (es) 2021-11-03 2024-08-06 Janssen Biotech Inc Métodos para tratar cánceres y potenciar la eficacia de anticuerpos biespecíficos para bcmaxcd3.
JP7799154B2 (ja) * 2022-01-14 2026-01-15 天津鍵凱科技有限公司 ヒアルロン酸誘導体又はその塩、その製造方法及び使用
KR20240135661A (ko) 2022-01-26 2024-09-11 브리스톨-마이어스 스큅 컴퍼니 간세포성 암종에 대한 조합 요법
WO2023164638A1 (fr) 2022-02-25 2023-08-31 Bristol-Myers Squibb Company Polythérapie pour carcinome colorectal
EP4469586A1 (fr) 2022-03-01 2024-12-04 Exuma Biotech Corp. Particules virales comprenant de l'hyaluronidase liée à une membrane
WO2023168404A1 (fr) 2022-03-04 2023-09-07 Bristol-Myers Squibb Company Méthodes de traitement d'une tumeur
CN114634920B (zh) * 2022-03-24 2024-02-27 江南大学 一种产人源透明质酸酶ph20的重组毕赤酵母及其构建方法
WO2023196987A1 (fr) 2022-04-07 2023-10-12 Bristol-Myers Squibb Company Méthodes de traitement d'une tumeur
TW202406551A (zh) 2022-04-22 2024-02-16 愛爾蘭商健生科學愛爾蘭無限公司 冷凍乾燥組成物(一)
CA3249515A1 (fr) 2022-04-22 2023-10-26 Janssen Sciences Ireland Unlimited Company Compositions liquides
EP4532547A1 (fr) 2022-05-24 2025-04-09 Bristol-Myers Squibb Company Anticorps se liant au ccr8 humain
KR20250022071A (ko) 2022-06-02 2025-02-14 브리스톨-마이어스 스큅 컴퍼니 항체 조성물 및 이의 이용 방법
KR20250097946A (ko) 2022-11-02 2025-06-30 얀센 바이오테크 인코포레이티드 암을 치료하는 방법
EP4638503A1 (fr) 2022-12-21 2025-10-29 Bristol-Myers Squibb Company Polythérapie contre le cancer du poumon
EP4637716A1 (fr) 2022-12-22 2025-10-29 Halozyme, Inc. Formulations d'enzyme hyaluronidase pour administration à volume élevé
AU2024237541A1 (en) 2023-03-13 2025-08-28 Heidelberg Pharma Research Gmbh Subcutaneously administered antibody-drug conjugates for use in cancer treatment
CN116253809B (zh) * 2023-04-19 2024-11-05 广州润虹医药科技股份有限公司 一种去除壳聚糖中内毒素的方法
WO2025059266A1 (fr) * 2023-09-12 2025-03-20 Sentrimed, Inc. Récepteur de podoplanine humain recombinant soluble
WO2025068923A2 (fr) 2023-09-26 2025-04-03 Takeda Pharmaceutical Company Limited Formulations d'immunoglobulines appauvries en iga
AU2024360739A1 (en) 2023-10-12 2026-04-02 Janssen Biotech, Inc. Methods for treating multiple myeloma comprising an anti-cd38 antibody combined with bortezomib, lenalidomide and dexamethasone
WO2025096611A1 (fr) * 2023-11-02 2025-05-08 Siemens Healthcare Diagnostics Inc. Compositions de réactifs pour dosages immunologiques et leur utilisation dans la détection d'antigène cancéreux 19-9
CN117887691B (zh) * 2023-12-27 2024-07-12 山东福瑞达医药集团有限公司 一种透明质酸酶融合蛋白、酵母工程菌及构建方法与应用
WO2025155877A2 (fr) 2024-01-18 2025-07-24 The Regents Of The University Of California Anticorps se liant à la pad4 humaine et leurs utilisations
WO2025158277A1 (fr) 2024-01-22 2025-07-31 Janssen Biotech, Inc. Utilisation d'amivantamab pour traiter le cancer de la tête et du cou
WO2025191459A1 (fr) 2024-03-11 2025-09-18 Janssen Biotech, Inc. Utilisation d'anticorps anti-egfr/c-met bispécifiques pour traiter des tumeurs solides
KR102687341B1 (ko) * 2024-04-09 2024-07-23 주식회사 휴온스랩 온전한 형태의 히알루로니다제의 생산방법
WO2025245489A1 (fr) 2024-05-24 2025-11-27 Bristol-Myers Squibb Company Traitement de tumeurs chez des sujets dont les échantillons sont positifs à fgl-1
WO2025248465A1 (fr) 2024-05-29 2025-12-04 Janssen Biotech, Inc. Traitement du cancer du poumon non à petites cellules localement avancé ou métastatique ayant subi une mutation d'egfr
WO2025262427A1 (fr) 2024-06-19 2025-12-26 Levicept Limited Formulation injectable
WO2025264972A1 (fr) 2024-06-21 2025-12-26 Apogee Therapeutics, Inc. Anticorps se liant à il -4 ralpha et anticorps se liant
WO2025264960A1 (fr) 2024-06-21 2025-12-26 Apogee Therapeutics, Inc. Anticorps qui se lient à il -13 et anticorps qui se lient à ox40l
WO2026022739A1 (fr) 2024-07-23 2026-01-29 Janssen Biotech, Inc. Polythérapies pour le traitement du cancer colorectal
WO2026022733A1 (fr) 2024-07-23 2026-01-29 Janssen Biotech, Inc. Polythérapies pour le traitement du cancer colorectal
WO2026028163A1 (fr) 2024-08-01 2026-02-05 Janssen Biotech, Inc. Méthodes de traitement du myélome multiple indolent à haut risque
WO2026028164A1 (fr) 2024-08-01 2026-02-05 Janssen Biotech, Inc. Daratumumab, bortézomib, lénalidomide et dexaméthasone pour le traitement du myélome multiple
WO2026078659A1 (fr) 2024-10-11 2026-04-16 Janssen Biotech, Inc. Combinaison d'un anticorps trispécifique ciblant bcma, gprc5d et cd3 et d'un anticorps anti-cd38 pour le traitement du myélome multiple
WO2026085415A1 (fr) 2024-10-18 2026-04-23 Apogee Therapeutics, Inc. Anticorps se liant à il-13 et anticorps se liant à tslp en combinaison avec de l'hyaluronidase ou un variant de celle-ci
WO2026085414A1 (fr) 2024-10-18 2026-04-23 Apogee Therapeutics, Inc. Anticorps se liant à tslp et anticorps se liant au récepteur alpha de l'interleukine 4 en combinaison avec de l'hyaluronidase ou un variant de celle-ci
WO2026085419A2 (fr) 2024-10-18 2026-04-23 Apogee Therapeutics, Inc. Anticorps qui se lient à il-13 en combinaison avec de l'hyaluronidase ou un variant de celle-ci
CN118969102B (zh) * 2024-10-18 2025-02-18 南京汉卫公共卫生研究院有限公司 一种基于数据融合分析的肿瘤组织分子智能分析识别系统
WO2026085417A2 (fr) 2024-10-18 2026-04-23 Apogee Therapeutics, Inc. Anticorps qui se lient au récepteur alpha de l'interleukine 4 en combinaison avec l'hyaluronidase ou un variant de celle-ci

Family Cites Families (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US172892A (en) * 1876-02-01 Improvement in restaurant check-boxes
US53247A (en) * 1866-03-13 Improved process for disintegrating fibers
US305500A (en) * 1884-09-23 Window-bead fastener
US8309A (en) * 1851-08-26 Washing-machine
US345770A (en) * 1886-07-20 Halp to nathan s
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3630200A (en) 1969-06-09 1971-12-28 Alza Corp Ocular insert
US3639200A (en) * 1969-12-19 1972-02-01 Armin Elmendorf Textured wood panel
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3847770A (en) 1972-04-10 1974-11-12 Continental Can Co Photopolymerizable compositions prepared from beta hydroxy esters and polyitaconates
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
USRE28819E (en) 1972-12-08 1976-05-18 Syntex (U.S.A.) Inc. Dialkylated glycol compositions and medicament preparations containing same
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4002531A (en) 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
JPS6033474B2 (ja) * 1978-05-11 1985-08-02 藤沢薬品工業株式会社 新規なヒアルロニダ−ゼｂｍｐ−８２３１およびその製造法
US4573994A (en) 1979-04-27 1986-03-04 The Johns Hopkins University Refillable medication infusion apparatus
US4410545A (en) 1981-02-13 1983-10-18 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4328245A (en) 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4358603A (en) 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
EP0162007A1 (fr) * 1984-04-18 1985-11-21 Geriaco AG Préparation stable et conservable d'insuline pour le traitement de l'acné vulgaris
US4769027A (en) 1984-08-15 1988-09-06 Burroughs Wellcome Co. Delivery system
GB8504025D0 (en) 1985-02-16 1985-03-20 Biopharm Ltd Hyaluronidase
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4687610A (en) 1986-04-30 1987-08-18 E. I. Du Pont De Neumours And Company Low crystallinity polyester yarn produced at ultra high spinning speeds
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
WO1988002261A1 (fr) 1986-09-30 1988-04-07 Biochemie Gesellschaft M.B.H. Utilisation de hyaluronidase
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US5723147A (en) 1987-02-23 1998-03-03 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
US5041292A (en) 1988-08-31 1991-08-20 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US5033352A (en) 1989-01-19 1991-07-23 Yamaha Corporation Electronic musical instrument with frequency modulation
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
DK0400472T3 (da) 1989-05-27 1996-05-13 Sumitomo Pharma Fremgangsmåde til fremstilling af polyethylenglycolderivater og modificeret protein
DE3921528A1 (de) 1989-06-30 1991-01-10 Draegerwerk Ag Messzelle fuer den elektrochemischen gasnachweis
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5215899A (en) 1989-11-09 1993-06-01 Miles Inc. Nucleic acid amplification employing ligatable hairpin probe and transcription
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
ZA912770B (en) 1990-04-16 1992-01-29 Bethesda Eye Inst Enzymatic disinsertion of vitreous body
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
CA2092323A1 (fr) 1990-10-01 1992-04-02 George Y. Wu Ciblage de virus et de cellules pour internalisation selective par les cellules
US5721348A (en) 1990-12-14 1998-02-24 University Of Connecticut DNA encoding PH-20 proteins
CA2059733C (fr) * 1991-01-23 1999-10-05 Kazufumi Ogawa Pellicule impermeabilisee et oleofuge et methode de fabrication
EP0576592B1 (fr) 1991-03-18 2000-05-31 The Scripps Research Institute Oligosaccharides servant de substrats et d'inhibiteurs d'enzymes: procedes et compositions
CA2103064A1 (fr) 1991-05-14 1992-11-15 George Y. Wu Administration ciblee de genes codant pour des proteines immunogenes
DK0587738T3 (da) 1991-06-05 2000-12-18 Univ Connecticut Destineret levering af gener, som koder for sekretionsproteiner
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
AU3434393A (en) 1992-01-17 1993-08-03 Regents Of The University Of Michigan, The Targeted virus
EP0633943A4 (fr) 1992-04-03 1997-05-02 Alexander T Young Therapie genique utilisant des vecteurs viraux cibles.
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
JP3980657B2 (ja) 1992-06-26 2007-09-26 生化学工業株式会社 コンドロイチナーゼａｂｃ、その製造法及び医薬組成物
US5496718A (en) 1992-06-26 1996-03-05 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Chondroitinase ABC isolated from proteus vulgaris ATCC 6896
ES2157225T3 (es) 1992-10-09 2001-08-16 Advanced Tissue Sciences Inc Celulas hepaticas de reserva.
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5395619A (en) 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
US5354566A (en) 1993-06-02 1994-10-11 Kraft General Foods, Inc. Preparation of yeast-leavened dough crusts
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5766627A (en) 1993-11-16 1998-06-16 Depotech Multivescular liposomes with controlled release of encapsulated biologically active substances
IL112920A (en) 1994-03-07 2003-04-10 Dow Chemical Co Composition comprising a dendritic polymer complexed with at least one unit of biological response modifier and a process for the preparation thereof
GEP20002180B (en) 1994-03-31 2000-07-25 Amgen Inc Composition and Methods for Stimulating Megakaryocyte Growth and Differentiation
US5795569A (en) 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5747027A (en) 1995-04-07 1998-05-05 The Regents Of The University Of California BH55 hyaluronidase
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
WO1997014740A1 (fr) * 1995-10-19 1997-04-24 Receptagen Corporation Polyethylene glycols de longueur discrete
US6610292B2 (en) 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US6828431B1 (en) * 1999-04-09 2004-12-07 Corixa Corporation Compositions and methods for the therapy and diagnosis of breast cancer
US6784023B2 (en) * 1996-05-20 2004-08-31 Micron Technology, Inc. Method of fabrication of stacked semiconductor devices
DE69734060T2 (de) 1996-05-24 2006-06-29 Angiotech Pharmaceuticals, Inc., Vancouver Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege
US5958750A (en) 1996-07-03 1999-09-28 Inctye Pharmaceuticals, Inc. Human hyaluronidase
US5665069A (en) * 1996-07-19 1997-09-09 Cumer; Patricia Lynn Pressure-directed peribulbar anesthesia delivery device
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US6193963B1 (en) 1996-10-17 2001-02-27 The Regents Of The University Of California Method of treating tumor-bearing patients with human plasma hyaluronidase
US6123938A (en) 1996-10-17 2000-09-26 The Regents Of The University Of California Human urinary hyaluronidase
US6103525A (en) 1996-10-17 2000-08-15 The Regents Of The University Of California Hybridoma cell lines producing monoclonal antibodies that bind to human plasma hyaluronidase
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
DE69836858T2 (de) * 1997-05-22 2007-09-06 Ista Pharmaceuticals, Inc., La Jolla Verwendung von hyaluronidase zur herstellung eines augenpräparats zur glasskörperverflüssigung bei der behandlung von augenerkrankungen
FR2763958A1 (fr) * 1997-05-29 1998-12-04 Transgene Sa Produit de combinaison associant un acide nucleique a une substance desorganisant la matrice extracellulaire pour la therapie genique
SE512633C2 (sv) 1997-07-09 2000-04-17 Cecilia Johnsson Användning av hyaluronidas för reduktion av inflammatoriska cellinfiltrat
US6448369B1 (en) 1997-11-06 2002-09-10 Shearwater Corporation Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
JP4078032B2 (ja) 1998-03-12 2008-04-23 ネクター セラピューティックス エイエル，コーポレイション 近位の反応性基を持つポリ（エチレングリコール）誘導体
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
JP2002533473A (ja) 1998-12-23 2002-10-08 イーデー ファーマ ゲーエムベーハー 微生物起源のヒアルロン酸分解酵素を含有する薬学的配合物
US6528797B1 (en) * 1999-04-16 2003-03-04 The Regents Of The University Of Michigan Method and system for determining depth distribution of radiation-emitting material located in a source medium and radiation detector system for use therein
WO2000066139A2 (fr) 1999-04-29 2000-11-09 Ista Pharmaceuticals, Inc. Procedes biochimiques permettant d'eliminer les taies, les opacifications et le flou de la cornee
JO2291B1 (en) 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythropoietin derivatives
US6461802B1 (en) 1999-08-02 2002-10-08 Agfa-Gevaert Adhesive layer for polyester film
HK1047109A1 (zh) 1999-10-15 2003-02-07 University Of Massachusetts 作为指定基因干预工具的rna干预轨迹基因
CA2394980C (fr) 1999-12-22 2008-05-13 Shearwater Corporation Derives de polymeres hydrosolubles a empechement sterique
US6413507B1 (en) 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
US20030212021A1 (en) * 2001-01-25 2003-11-13 Frost Gregory I. Myeloid colony stimulating factor and uses thereof
AU784155B2 (en) 2000-01-25 2006-02-09 Halozyme, Inc. Myeloid colony stimulating factor and uses thereof
US6602498B2 (en) 2000-02-22 2003-08-05 Shearwater Corporation N-maleimidyl polymer derivatives
DE10013735A1 (de) * 2000-03-23 2001-10-11 Bakelite Ag Härter für Epoxidverbindungen, Verfahren zu ihrer Herstellung und Verwendung
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US6745776B2 (en) 2001-04-10 2004-06-08 David B. Soll Methods for reducing postoperative intraocular pressure
FR2827377B1 (fr) * 2001-07-13 2003-12-05 Poudres & Explosifs Ste Nale Dispositif d'allumage pour microcharges pyrotechniques
US20040224012A1 (en) 2001-10-05 2004-11-11 Pichit Suvanprakorn Topical application and methods for administration of active agents using liposome macro-beads
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
EP1446438A2 (fr) 2001-11-07 2004-08-18 Nektar Therapeutics Al, Corporation Polymeres ramifies et conjugues associes
US7368108B2 (en) * 2001-11-28 2008-05-06 Neose Technologies, Inc. Glycopeptide remodeling using amidases
US7064110B2 (en) 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
US7049483B1 (en) 2002-07-15 2006-05-23 Bruce Eric Hudkins Transgenic bioluminescent plants
US6682904B1 (en) 2002-08-15 2004-01-27 Deliatroph Pharmaceuticals, Inc. Specific inhibitors of hyaluronidase 2, and methods of identifying and using same
KR20040040782A (ko) 2002-11-08 2004-05-13 선바이오(주) 신규한 헥사-암 폴리에틸렌글리콜과 유도체 및 그의합성방법
CA2508948A1 (fr) 2002-12-16 2004-07-15 Halozyme, Inc. Glycoproteine de chondroitinase (chasegp) humaine, son procede de preparation et compositions pharmaceutiques comprenant ladite glycoproteine
US20080124360A1 (en) 2003-01-24 2008-05-29 Seggern Daniel J Von Adenovirus particles with enhanced infectivity of dendritic cells and particles with decreased infectivity of hepatocytes
US6969514B2 (en) * 2003-02-05 2005-11-29 Soll David B Method for treating elevated intraocular pressure, including glaucoma
US20090123367A1 (en) 2003-03-05 2009-05-14 Delfmems Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
NZ542873A (en) 2003-03-05 2008-07-31 Halozyme Inc Soluble, neutral-active hyaluronidase activity glycoprotein (sHASEGP) that is produced with high yield in a mammalian expression system by introducing nucleic acids that lack a narrow region encoding amino acids in the carboxy terminus of the human PH20 cDNA
US7871607B2 (en) * 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US7610156B2 (en) 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
CA2522544A1 (fr) 2003-04-15 2004-10-28 Ista Pharmaceuticals, Inc. Procede d'isolation et de purification d'hyaluronidase ovine
WO2004098500A2 (fr) 2003-04-30 2004-11-18 Trine Pharmaceuticals, Inc. Beta-lactamine de la classe des carbacephems
KR100512483B1 (ko) 2003-05-07 2005-09-05 선바이오(주) 신규한 폴리에틸렌글리콜-말레이미드 유도체의 합성방법
EP3211084B1 (fr) 2003-05-16 2019-03-27 Acorda Therapeutics, Inc. Mutants de degradation du proteoglycane pour le traitement du systeme nerveux central
CA2535489C (fr) 2003-08-14 2014-09-30 D. Collen Research Foundation Vzw Anticorps permettant de lutter contre le facteur viii avec glycosylationmodifiee dans la region variable
WO2005030927A2 (fr) 2003-09-23 2005-04-07 Uab Research Foundation Procedes et compositions pour le controle de l'inflammation in vivo
WO2005118799A1 (fr) 2004-04-15 2005-12-15 Ista Pharmaceuticals, Inc. Hyaluronidase ovine
JP2008502690A (ja) 2004-06-15 2008-01-31 アンドリュー シァン チェン， リン脂質組成物ならびにその調製方法および使用方法
US7572613B2 (en) 2004-06-25 2009-08-11 Klein Jeffrey A Drug delivery system for accelerated subcutaneous absorption
JP3912395B2 (ja) 2004-07-12 2007-05-09 セイコーエプソン株式会社 半導体集積回路、検査装置および半導体集積回路の検査方法
US20060292682A1 (en) 2004-07-22 2006-12-28 Hawkins Lynda K Addition of transgenes into adenoviral vectors
US20060181032A1 (en) * 2005-02-11 2006-08-17 Riggs Robert A Hybrid gasket
WO2007047242A2 (fr) 2005-10-14 2007-04-26 Soll David B Solutions irrigantes pour chirurgie ophtalmique contenant de la hyaluronidase et procede permettant d'eviter l'augmentation de la pression intra-oculaire post-operatoire
US20070172846A1 (en) 2005-11-12 2007-07-26 Introgen Therapeutics, Inc. Methods for the Production and Purification of Adenoviral Vectors
WO2007098479A2 (fr) 2006-02-21 2007-08-30 University Of Medicine And Dentistry Of New Jersey Délivrance localisée d'insuline pour guérison osseuse
US8170830B2 (en) 2006-08-22 2012-05-01 Jacobs James P Method and system for providing tolerance to interference and obstructions of line of sight
JPWO2009001670A1 (ja) 2007-06-05 2010-08-26 帝人株式会社 ポリカーボネート樹脂組成物
RU2471867C2 (ru) * 2007-06-19 2013-01-10 Тамара П. Уваркина Гиалуронидаза и способ ее применения
JP4931230B2 (ja) 2007-06-22 2012-05-16 新菱冷熱工業株式会社 クリーンルームの空調方法及び空調装置
US8956412B2 (en) 2007-06-22 2015-02-17 Axiomed, LLC Artificial disc
US20080314349A1 (en) 2007-06-25 2008-12-25 Robert Bosch Gmbh Green start engine control systems and methods
WO2009001455A1 (fr) 2007-06-27 2008-12-31 Hitachi, Ltd. Dispositif d'affichage à plasma
TWI395593B (zh) * 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
SI4269578T1 (sl) 2008-03-06 2024-07-31 Halozyme, Inc. Sestava topne hialuronidaze
TWI489994B (zh) * 2008-03-17 2015-07-01 Baxter Healthcare Sa 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
US20090311237A1 (en) 2008-04-14 2009-12-17 Frost Gregory I Combination therapy using a soluble hyaluronidase and a bisphosphonate
KR20130116386A (ko) 2008-04-14 2013-10-23 할로자임, 아이엔씨 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도
TWI394580B (zh) 2008-04-28 2013-05-01 Halozyme Inc 超快起作用胰島素組成物
US8315366B2 (en) * 2008-07-22 2012-11-20 Shoretel, Inc. Speaker identification and representation for a phone
EA022752B1 (ru) * 2008-12-09 2016-02-29 Галозим, Инк. Длинные растворимые полипептиды рн20 и их использование
EP2403523A1 (fr) 2009-03-06 2012-01-11 Halozyme, Inc. Mutants thermosensibles de métalloprotéase matricielle 1 et leurs utilisations
ES2385251B1 (es) 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge Adenovirus oncolíticos para el tratamiento del cáncer.
WO2010138918A1 (fr) 2009-05-29 2010-12-02 Pacira Pharmaceuticals, Inc. Hyaluronidase comme adjuvant pour augmenter le volume d'injection et la dispersion de vésicules membranaires synthétiques de grand diamètre contenant un agent thérapeutique
HUE028832T2 (en) 2009-09-17 2017-01-30 Baxalta Inc Stable co-formulation of hyaluronidase and immunoglobulin, as well as a process for its preparation
WO2012012300A2 (fr) 2010-07-20 2012-01-26 Halozyme, Inc. Effets secondaires indésirables associés à l'administration d'un agent anti-hyaluronane et procédés pour améliorer ou prévenir ces effets secondaires
MX349622B (es) 2010-09-08 2017-08-07 Halozyme Inc Metodos para evaluar e identificar o evolucionar proteinas terapeuticas condicionalmente activas.
WO2012109387A1 (fr) * 2011-02-08 2012-08-16 Halozyme, Inc. Composition et formulation lipidique d'une enzyme dégradant le hyaluronane et son utilisation pour le traitement de l'hyperplasie bénigne de la prostate
CA2839512C (fr) * 2011-06-17 2018-01-02 Halozyme, Inc. Procedes de perfusion d'insuline sous-cutanee continue utilisant une enzyme de degradation de l'hyaluronane
US20130011378A1 (en) * 2011-06-17 2013-01-10 Tzung-Horng Yang Stable formulations of a hyaluronan-degrading enzyme
JP6029674B2 (ja) 2011-10-18 2016-11-24 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 第ｖｉｉｉ因子のバイオアベイラビリティを改善するための、硫酸化グリコサミノグリカン及びヒアルロニダーゼの組み合わせ使用
JP6162707B2 (ja) * 2011-10-24 2017-07-12 ハロザイム インコーポレイテッド 抗ヒアルロナン剤治療のためのコンパニオン診断およびその使用方法
WO2013102144A2 (fr) 2011-12-30 2013-07-04 Halozyme, Inc. Variants du polypeptide ph20, formulations en contenant et leurs utilisations
CN108686203A (zh) 2012-04-04 2018-10-23 哈洛齐梅公司 使用抗透明质酸剂和肿瘤靶向紫杉烷的组合疗法
CN105727267B (zh) 2016-02-05 2020-05-26 苏州康聚生物科技有限公司 一种重组人透明质酸酶冻干制剂及其制备方法和应用
MX2020009824A (es) 2018-07-25 2021-01-15 Alteogen Inc Nuevas variantes de hialuronidasa y composicion farmaceutica que comprende la misma.

Also Published As

Publication number Publication date
KR20110114692A (ko) 2011-10-19
PT1603541E (pt) 2010-02-19
CY2015033I2 (el) 2016-06-22
FR16C0030I1 (fr) 2016-08-26
EP2177620A1 (fr) 2010-04-21
ES2335005T5 (es) 2013-04-17
US8765685B2 (en) 2014-07-01
KR20050118273A (ko) 2005-12-16
LU92780I2 (fr) 2015-09-21
US20140199282A1 (en) 2014-07-17
EP2163643B1 (fr) 2015-01-21
US8772246B2 (en) 2014-07-08
HK1138885A1 (en) 2010-09-03
JP2010029190A (ja) 2010-02-12
NZ542873A (en) 2008-07-31
CY2016024I2 (el) 2017-06-28
PL2405015T3 (pl) 2016-09-30
US20120148555A1 (en) 2012-06-14
HUS1600031I1 (hu) 2016-08-29
HK1165834A1 (en) 2012-10-12
CY1117358T1 (el) 2017-04-26
AU2009245838A1 (en) 2010-01-07
US20120251620A1 (en) 2012-10-04
US20230321203A1 (en) 2023-10-12
JP5756785B2 (ja) 2015-07-29
US20090214505A1 (en) 2009-08-27
US8431380B2 (en) 2013-04-30
EP3009517A1 (fr) 2016-04-20
CN102943067A (zh) 2013-02-27
US20190224286A1 (en) 2019-07-25
US10898551B2 (en) 2021-01-26
US7767429B2 (en) 2010-08-03
SI2405015T1 (sl) 2016-04-29
EP2177620B1 (fr) 2014-11-19
IL227867A0 (en) 2013-09-30
US20090181032A1 (en) 2009-07-16
KR20120094493A (ko) 2012-08-24
EP2330213A1 (fr) 2011-06-08
PL1603541T5 (pl) 2013-06-28
EP1603541A4 (fr) 2006-11-22
EP1603541B2 (fr) 2013-01-23
CY1109750T1 (el) 2014-09-10
BRPI0408116B1 (pt) 2022-09-20
JP4464395B2 (ja) 2010-05-19
CY2016024I1 (el) 2017-06-28
CY1116110T1 (el) 2017-02-08
ES2335005T3 (es) 2010-03-18
CY1116370T1 (el) 2016-06-22
EP2405015A3 (fr) 2012-03-07
CA2517145C (fr) 2017-08-01
US20090253175A1 (en) 2009-10-08
AU2004218354A1 (en) 2004-09-16
SI1603541T2 (sl) 2013-04-30
US9677061B2 (en) 2017-06-13
PT2177620E (pt) 2015-02-16
DK1603541T3 (da) 2010-03-29
US8450470B2 (en) 2013-05-28
SG177008A1 (en) 2012-01-30
US20130058893A1 (en) 2013-03-07
US8431124B2 (en) 2013-04-30
AU2009245838B2 (en) 2013-05-09
CN102943067B (zh) 2016-06-22
PL2177620T3 (pl) 2015-05-29
US9677062B2 (en) 2017-06-13
CY2015033I1 (el) 2016-06-22
CA2517145A1 (fr) 2004-09-16
EP1603541A2 (fr) 2005-12-14
SG2012041067A (en) 2014-08-28
EP2405015B1 (fr) 2016-01-06
ZA200507978B (en) 2007-03-28
KR20130135986A (ko) 2013-12-11
EA200501384A1 (ru) 2006-06-30
DK1603541T4 (da) 2013-04-15
ES2564103T3 (es) 2016-03-17
JP2013031446A (ja) 2013-02-14
ES2526536T3 (es) 2015-01-13
US11723959B2 (en) 2023-08-15
JP2006524507A (ja) 2006-11-02
PT2163643E (pt) 2015-05-18
WO2004078140A2 (fr) 2004-09-16
WO2004078140A3 (fr) 2005-11-17
EP1603541B1 (fr) 2009-11-11
ES2532399T3 (es) 2015-03-26
IL227867A (en) 2015-09-24
US20090181013A1 (en) 2009-07-16
US20040268425A1 (en) 2004-12-30
DK2163643T3 (en) 2015-03-23
ATE448323T1 (de) 2009-11-15
JP5538770B2 (ja) 2014-07-02
PL2163643T3 (pl) 2015-06-30
EA009383B1 (ru) 2007-12-28
EP2405015A2 (fr) 2012-01-11
SI2163643T1 (sl) 2015-03-31
CN1942588B (zh) 2013-06-12
US20110152359A1 (en) 2011-06-23
KR101233457B1 (ko) 2013-02-15
EP2163643A1 (fr) 2010-03-17
DK2405015T3 (en) 2016-03-21
US9562223B2 (en) 2017-02-07
SI1603541T1 (sl) 2010-03-31
AU2004218354B2 (en) 2009-10-01
DK2177620T3 (en) 2015-01-26
HUE027661T2 (en) 2016-10-28
US10286044B2 (en) 2019-05-14
CN1942588A (zh) 2007-04-04
DE602004024041D1 (de) 2009-12-24
IL170300A (en) 2016-06-30
LU93138I2 (fr) 2016-09-05
HK1086746A1 (en) 2006-09-29
US20170246264A1 (en) 2017-08-31
BRPI0408116A (pt) 2006-03-01
EP2311973A1 (fr) 2011-04-20
PL1603541T3 (pl) 2010-04-30
HK1138883A1 (en) 2010-09-03
KR101363658B1 (ko) 2014-02-14
SI2177620T1 (sl) 2015-02-27
US8202517B2 (en) 2012-06-19
US20210023184A1 (en) 2021-01-28
MXPA05009429A (es) 2005-12-12

Similar Documents

Publication Publication Date Title
BE2013C067I2 (fr)
BE2013C038I2 (fr)
BE2013C036I2 (fr)
BE2011C030I2 (fr)
JP2004128457A5 (fr)
JP2004219569A5 (fr)
BE2013C034I2 (fr)
BE2012C053I2 (fr)
JP2004188174A5 (fr)
JP2004160164A5 (fr)
AU2002339901A1 (fr)
AU2002331433A1 (fr)
AU2003210772A1 (fr)
AU2002362930A1 (fr)
AU2002350272A1 (fr)
AU2002348177A1 (fr)
AU2002345911A1 (fr)
AU2001256599A1 (fr)
AU2002341905A1 (fr)
AU2001282632A1 (fr)
AU2002239060A1 (fr)
AU2002341898A1 (fr)
AU2002340206A1 (fr)
AU2002351829A1 (fr)
AU2002242943A1 (fr)